9595:RBM15
gene id: 9595:RBM15
uniprot id: G3QM63
names: Similarity
messages: Belongs to the RRM Spen family.

9595:FUNDC2
gene id: 9595:FUNDC2
uniprot id: A0A2I2ZER9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9595:CPXM2
gene id: 9595:CPXM2
uniprot id: G3QW16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9595:HIRIP3
gene id: 9595:HIRIP3
uniprot id: G3R8J2
names: Subcellular Location Annotation
messages: Nucleus

9595:BGLAP
gene id: 9595:BGLAP
uniprot id: P84349
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation by GGCX. These residues are essential for the binding of calcium (By similarity). Decarboxylation promotes the hormone activity (By similarity).
messages: Secreted
messages: The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium.
messages: The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.

9595:SLC30A5
gene id: 9595:SLC30A5
uniprot id: G3RGM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9595:DHH
gene id: 9595:DHH
uniprot id: G3QY79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9595:CASP10
gene id: 9595:CASP10
uniprot id: A0A2I2Y8W2
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:GNB4
gene id: 9595:GNB4
uniprot id: G3SB40
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9595:ADGRG5
gene id: 9595:ADGRG5
uniprot id: G3RE93
names: Subcellular Location Annotation
messages: Membrane

9595:INO80C
gene id: 9595:INO80C
uniprot id: G3RZA7
uniprot id: G3SIV1
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101148825
gene id: 9595:LOC101148825
uniprot id: G3SJB3
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9595:PAPOLG
gene id: 9595:PAPOLG
uniprot id: G3QTE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

9595:PPP4C
gene id: 9595:PPP4C
uniprot id: G3QZX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9595:SLC16A3
gene id: 9595:SLC16A3
uniprot id: G3QCW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9595:FAM163A
gene id: 9595:FAM163A
uniprot id: G3QYC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9595:TMPRSS11D
gene id: 9595:TMPRSS11D
uniprot id: G3QFY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9595:NT5E
gene id: 9595:NT5E
uniprot id: G3QF23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9595:ALG2
gene id: 9595:ALG2
uniprot id: G3QNK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

9595:HTR1D
gene id: 9595:HTR1D
uniprot id: G3QIH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9595:EXTL1
gene id: 9595:EXTL1
uniprot id: G3RJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:TYSND1
gene id: 9595:TYSND1
uniprot id: G3RKH0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

9595:DACT2
gene id: 9595:DACT2
uniprot id: G3RXL6
names: Similarity
messages: Belongs to the dapper family.

9595:TSC22D3
gene id: 9595:TSC22D3
uniprot id: G3QR51
uniprot id: G3S667
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9595:HARBI1
gene id: 9595:HARBI1
uniprot id: G3QP39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9595:SETD2
gene id: 9595:SETD2
uniprot id: A0A2I2Z1X0
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9595:SUPT3H
gene id: 9595:SUPT3H
uniprot id: G3RFB2
names: Subcellular Location Annotation
messages: Nucleus

9595:SAP30L
gene id: 9595:SAP30L
uniprot id: G3QP70
names: Similarity
messages: Belongs to the SAP30 family.

9595:PPP2R5A
gene id: 9595:PPP2R5A
uniprot id: A0A2I2YD04
uniprot id: G3SAH2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9595:LOC101129851
gene id: 9595:LOC101129851
uniprot id: G3QHN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9595:PAPPA2
gene id: 9595:PAPPA2
uniprot id: G3QJM0
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101139167
gene id: 9595:LOC101139167
uniprot id: A0A2I2YI12
uniprot id: G3RUW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9595:CTNNB1
gene id: 9595:CTNNB1
uniprot id: A0A2I2ZNM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9595:SLC12A5
gene id: 9595:SLC12A5
uniprot id: G3SBB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9595:BCAT1
gene id: 9595:BCAT1
uniprot id: A0A2I2YG10
uniprot id: A0A2I2ZT82
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9595:DHTKD1
gene id: 9595:DHTKD1
uniprot id: A0A2I2YYP5
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9595:ADGRG7
gene id: 9595:ADGRG7
uniprot id: G3R5N7
names: Subcellular Location Annotation
messages: Membrane

9595:RAD21
gene id: 9595:RAD21
uniprot id: G3R826
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9595:FIGN
gene id: 9595:FIGN
uniprot id: A0A2I2YB11
names: Similarity
messages: Belongs to the AAA ATPase family.

9595:ATP7B
gene id: 9595:ATP7B
uniprot id: G3RTU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9595:PCK1
gene id: 9595:PCK1
uniprot id: G3R5Y2
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Monomer.

9595:ODF1
gene id: 9595:ODF1
uniprot id: G3S8C1
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9595:VTI1B
gene id: 9595:VTI1B
uniprot id: G3S921
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9595:APOC3
gene id: 9595:APOC3
uniprot id: G3QY94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

9595:REEP5
gene id: 9595:REEP5
uniprot id: A0A2I2YAD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9595:SERPINB5
gene id: 9595:SERPINB5
uniprot id: G3RPE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

9595:MON1A
gene id: 9595:MON1A
uniprot id: A0A2I2YX97
uniprot id: G3R9A5
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9595:USP44
gene id: 9595:USP44
uniprot id: G3R033
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:CHD8
gene id: 9595:CHD8
uniprot id: A0A2I2YBF5
uniprot id: A0A2I2ZB14
uniprot id: A0A2I2ZYX2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

9595:NMD3
gene id: 9595:NMD3
uniprot id: G3RWY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9595:DYDC1
gene id: 9595:DYDC1
uniprot id: G3QJS4
uniprot id: G3RUS7
names: Similarity
messages: Belongs to the dpy-30 family.

9595:MEIG1
gene id: 9595:MEIG1
uniprot id: G3RL95
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9595:LOC101146696
gene id: 9595:LOC101146696
uniprot id: G3QGD7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:CSRNP1
gene id: 9595:CSRNP1
uniprot id: G3RKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9595:GPC1
gene id: 9595:GPC1
uniprot id: G3QGJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9595:ACP5
gene id: 9595:ACP5
uniprot id: G3R9M5
names: Cofactor
messages: Binds 2 iron ions per subunit.

9595:RAD18
gene id: 9595:RAD18
uniprot id: G3QZ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9595:DVL2
gene id: 9595:DVL2
uniprot id: G3SDP9
names: Similarity
messages: Belongs to the DSH family.

9595:PIK3C3
gene id: 9595:PIK3C3
uniprot id: A0A2I2ZRM9
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9595:GATA6
gene id: 9595:GATA6
uniprot id: G3RZ55
names: Subcellular Location Annotation
messages: Nucleus

9595:RPL39L
gene id: 9595:RPL39L
uniprot id: A0A2I2YLB6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9595:CSN3
gene id: 9595:CSN3
uniprot id: G3QUL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Secreted

9595:LOC101126098
gene id: 9595:LOC101126098
uniprot id: G3QKC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:RUSF1
gene id: 9595:RUSF1
uniprot id: G3QP92
names: Similarity
messages: Belongs to the RUS1 family.

9595:LOC101154255
gene id: 9595:LOC101154255
uniprot id: A0A2I2ZRC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TMPO
gene id: 9595:TMPO
uniprot id: A0A2I2YV01
uniprot id: G3QLH5
uniprot id: G3S0I0
names: Similarity
messages: Belongs to the LEM family.

9595:PLEKHA8
gene id: 9595:PLEKHA8
uniprot id: A0A2I2YJM2
names: Subcellular Location Annotation
messages: trans-Golgi network membrane

9595:PSMD3
gene id: 9595:PSMD3
uniprot id: G3SF47
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9595:NDUFS7
gene id: 9595:NDUFS7
uniprot id: Q0MQH9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Hydroxylated ar Arg-111 by NDUFAF5 early in the pathway of assembly of complex I, before the formation of the juncture between peripheral and membrane arms.
messages: Mitochondrion inner membrane

9595:WSCD2
gene id: 9595:WSCD2
uniprot id: A0A2I2ZK03
names: Function
names: Similarity
messages: Belongs to the WSCD family.
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9595:EBAG9
gene id: 9595:EBAG9
uniprot id: G3SGS2
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9595:NDUFA12
gene id: 9595:NDUFA12
uniprot id: A0A2I2YU58
uniprot id: Q0MQ86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:SLC25A11
gene id: 9595:SLC25A11
uniprot id: G3QDA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:POLR2M
gene id: 9595:POLR2M
uniprot id: A0A2I2Y892
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

9595:ABL2
gene id: 9595:ABL2
uniprot id: A0A2I2Z7C3
uniprot id: G3QJJ8
uniprot id: G3QJK0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9595:RETN
gene id: 9595:RETN
uniprot id: G3R281
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9595:PIM1
gene id: 9595:PIM1
uniprot id: G3S2M1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9595:ELMO3
gene id: 9595:ELMO3
uniprot id: G3R8E4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9595:PKIB
gene id: 9595:PKIB
uniprot id: A0A2I2Z436
uniprot id: G3RFZ3
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9595:LPAR2
gene id: 9595:LPAR2
uniprot id: G3QT70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:GALNT11
gene id: 9595:GALNT11
uniprot id: G3R0A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:DEFA6
gene id: 9595:DEFA6
uniprot id: G3R5P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9595:GUCY1B1
gene id: 9595:GUCY1B1
uniprot id: G3QW61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9595:PTTG1
gene id: 9595:PTTG1
uniprot id: G3RL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9595:NMUR2
gene id: 9595:NMUR2
uniprot id: G3QV11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9595:ANXA3
gene id: 9595:ANXA3
uniprot id: G3SEL8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9595:PKLR
gene id: 9595:PKLR
uniprot id: G3S6L6
names: Similarity
messages: Belongs to the pyruvate kinase family.

9595:VPS4B
gene id: 9595:VPS4B
uniprot id: G3QV21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:CTBP2
gene id: 9595:CTBP2
uniprot id: A0A2I2ZSE0
uniprot id: G3S0L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9595:CCDC25
gene id: 9595:CCDC25
uniprot id: G3R2K5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9595:GFRAL
gene id: 9595:GFRAL
uniprot id: G3S1J6
names: Similarity
messages: Belongs to the GDNFR family.

9595:MRPL51
gene id: 9595:MRPL51
uniprot id: G3RJB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Mitochondrion

9595:LMOD2
gene id: 9595:LMOD2
uniprot id: G3S961
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9595:FGF13
gene id: 9595:FGF13
uniprot id: A0A2I2YT95
uniprot id: G3R343
uniprot id: G3RVJ1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:FAM53B
gene id: 9595:FAM53B
uniprot id: G3QH12
names: Similarity
messages: Belongs to the FAM53 family.

9595:SLC23A2
gene id: 9595:SLC23A2
uniprot id: G3QXX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9595:NUDT17
gene id: 9595:NUDT17
uniprot id: G3QWG2
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

9595:NUDT7
gene id: 9595:NUDT7
uniprot id: A0A2I2YL84
uniprot id: G3RLI6
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9595:HTR7
gene id: 9595:HTR7
uniprot id: A0A2I2Z5A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:KIF1C
gene id: 9595:KIF1C
uniprot id: G3R1E6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:IAH1
gene id: 9595:IAH1
uniprot id: A0A2I2YXY6
uniprot id: G3QHB0
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9595:CPNE3
gene id: 9595:CPNE3
uniprot id: G3RZC4
names: Similarity
messages: Belongs to the copine family.

9595:TSPAN6
gene id: 9595:TSPAN6
uniprot id: A0A2I2Z184
uniprot id: G3R3D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:RARA
gene id: 9595:RARA
uniprot id: A0A2I2Z5W1
uniprot id: A0A2I2ZS07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:TMEM50B
gene id: 9595:TMEM50B
uniprot id: G3SKJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9595:MMP16
gene id: 9595:MMP16
uniprot id: A0A2I2Y1M9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:TRPV5
gene id: 9595:TRPV5
uniprot id: G3RIU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:CCDC103
gene id: 9595:CCDC103
uniprot id: G3SKG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9595:IL6R
gene id: 9595:IL6R
uniprot id: A0A2I2YXF5
uniprot id: G3QEX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Membrane

9595:MARK3
gene id: 9595:MARK3
uniprot id: A0A2I2Z9D1
uniprot id: A0A2I2ZM54
uniprot id: G3RNJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9595:MAP3K8
gene id: 9595:MAP3K8
uniprot id: G3QS35
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9595:P4HA1
gene id: 9595:P4HA1
uniprot id: A0A2I2Z3V0
uniprot id: A0A2I2Z806
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9595:GPX7
gene id: 9595:GPX7
uniprot id: G3RFD9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9595:PPARA
gene id: 9595:PPARA
uniprot id: A0A2I2Z0P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
messages: Nucleus

9595:SPC24
gene id: 9595:SPC24
uniprot id: A0A2I2ZIP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9595:SLC7A6OS
gene id: 9595:SLC7A6OS
uniprot id: G3QGS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

9595:MMP13
gene id: 9595:MMP13
uniprot id: G3QLR7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:SYNE1
gene id: 9595:SYNE1
uniprot id: G3RG48
names: Similarity
messages: Belongs to the nesprin family.

9595:LOC101125692
gene id: 9595:LOC101125692
uniprot id: G3RZG3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:FAM151A
gene id: 9595:FAM151A
uniprot id: G3R390
names: Similarity
messages: Belongs to the FAM151 family.

9595:GAPVD1
gene id: 9595:GAPVD1
uniprot id: A0A2I2YB47
uniprot id: A0A2I2YFX9
uniprot id: A0A2I2Z1H9
uniprot id: G3QGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9595:SLC25A39
gene id: 9595:SLC25A39
uniprot id: A0A2I2YJU3
uniprot id: G3QSS8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9595:PEX10
gene id: 9595:PEX10
uniprot id: G3R4P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9595:CRH
gene id: 9595:CRH
uniprot id: G3R2F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9595:P4HB
gene id: 9595:P4HB
uniprot id: G3SBE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9595:MPG
gene id: 9595:MPG
uniprot id: G3SGM8
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

9595:ADAM17
gene id: 9595:ADAM17
uniprot id: G3RBF9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TRIM36
gene id: 9595:TRIM36
uniprot id: A0A2I2Z3J5
uniprot id: G3RKS5
names: Subcellular Location Annotation
messages: cytoskeleton

9595:MYOD1
gene id: 9595:MYOD1
uniprot id: G3S3Y5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9595:PIGF
gene id: 9595:PIGF
uniprot id: G3RZI3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:RAB27B
gene id: 9595:RAB27B
uniprot id: G3RHZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9595:STEEP1
gene id: 9595:STEEP1
uniprot id: G3RBX9
names: Similarity
messages: Belongs to the STEEP1 family.

9595:DDX46
gene id: 9595:DDX46
uniprot id: A0A2I2YA69
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9595:SRSF1
gene id: 9595:SRSF1
uniprot id: G3QP16
names: Similarity
messages: Belongs to the splicing factor SR family.

9595:GET1
gene id: 9595:GET1
uniprot id: G3RBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:BMP10
gene id: 9595:BMP10
uniprot id: A0A2I2YG54
names: Similarity
messages: Belongs to the TGF-beta family.

9595:LOC101141704
gene id: 9595:LOC101141704
uniprot id: G3QEJ7
names: Subcellular Location Annotation
messages: Membrane

9595:SCT
gene id: 9595:SCT
uniprot id: G3RGI1
names: Similarity
messages: Belongs to the glucagon family.

9595:SCML4
gene id: 9595:SCML4
uniprot id: A0A2I2YHA8
uniprot id: G3QV70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9595:GLI1
gene id: 9595:GLI1
uniprot id: A0A2I2YT57
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9595:ABCA9
gene id: 9595:ABCA9
uniprot id: G3RJ50
names: Subcellular Location Annotation
messages: Membrane

9595:SNX17
gene id: 9595:SNX17
uniprot id: G3R5X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9595:NUDT4
gene id: 9595:NUDT4
uniprot id: G3REH8
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9595:LOC101152880
gene id: 9595:LOC101152880
uniprot id: Q8HY06
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Membrane
messages: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity).
messages: The tandem repeat domain, also called neck domain, mediates oligomerization.

9595:WDR4
gene id: 9595:WDR4
uniprot id: G3RKI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat TRM82 family.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

9595:OPRM1
gene id: 9595:OPRM1
uniprot id: A0A2I2ZCV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

9595:KCNMB2
gene id: 9595:KCNMB2
uniprot id: G3RI99
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9595:RALY
gene id: 9595:RALY
uniprot id: G3S2S1
uniprot id: G3SGA9
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9595:ENO3
gene id: 9595:ENO3
uniprot id: A0A2I2Y9H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9595:EIF4A1
gene id: 9595:EIF4A1
uniprot id: G3SGA8
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9595:LOC109024475
gene id: 9595:LOC109024475
uniprot id: G3RG10
names: Similarity
names: Subunit
messages: Belongs to the KRTAP type 6 family.
messages: Interacts with hair keratins.

9595:NT5C3B
gene id: 9595:NT5C3B
uniprot id: G3R3Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9595:PADI3
gene id: 9595:PADI3
uniprot id: G3RGV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9595:PRF1
gene id: 9595:PRF1
uniprot id: G3QHP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9595:SLC25A34
gene id: 9595:SLC25A34
uniprot id: G3RGQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:DNTT
gene id: 9595:DNTT
uniprot id: G3QFE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

9595:PARD6A
gene id: 9595:PARD6A
uniprot id: G3QMR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9595:NTN4
gene id: 9595:NTN4
uniprot id: A0A2I2Z326
uniprot id: G3RCW3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SPDL1
gene id: 9595:SPDL1
uniprot id: G3QLC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9595:GOLM2
gene id: 9595:GOLM2
uniprot id: G3SFZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9595:DEDD2
gene id: 9595:DEDD2
uniprot id: G3R148
names: Subcellular Location Annotation
messages: nucleolus

9595:CA1
gene id: 9595:CA1
uniprot id: Q7M316
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea.
messages: Cytoplasm
messages: Inhibited by acetazolamide.

9595:TRDMT1
gene id: 9595:TRDMT1
uniprot id: A0A2I2Y2J7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9595:GLMP
gene id: 9595:GLMP
uniprot id: A0A2I2Z1V4
uniprot id: A0A2I2ZIV1
uniprot id: G3REB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9595:NDUFB1
gene id: 9595:NDUFB1
uniprot id: G3RNN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:MMP3
gene id: 9595:MMP3
uniprot id: G3R469
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:UPF3A
gene id: 9595:UPF3A
uniprot id: A0A2I2Y5T4
uniprot id: G3SAR2
names: Similarity
messages: Belongs to the RENT3 family.

9595:EHF
gene id: 9595:EHF
uniprot id: A0A2I2YH19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:PC
gene id: 9595:PC
uniprot id: G3REY4
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

9595:MTX3
gene id: 9595:MTX3
uniprot id: G3QMU5
uniprot id: G3SFI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:STAMBPL1
gene id: 9595:STAMBPL1
uniprot id: G3RWC2
names: Similarity
messages: Belongs to the peptidase M67C family.

9595:APOM
gene id: 9595:APOM
uniprot id: G3RRQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9595:GALE
gene id: 9595:GALE
uniprot id: G3QNX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9595:RARB
gene id: 9595:RARB
uniprot id: G3S8K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:CUL4B
gene id: 9595:CUL4B
uniprot id: A0A2I2ZLQ4
names: Similarity
messages: Belongs to the cullin family.

9595:IRF5
gene id: 9595:IRF5
uniprot id: A0A2I2YFD3
uniprot id: A0A2I2Z7E3
uniprot id: G3R8K6
names: Subcellular Location Annotation
messages: Nucleus

9595:PHYHIPL
gene id: 9595:PHYHIPL
uniprot id: A0A2I2YUR1
uniprot id: A0A2I2ZQT4
uniprot id: G3R0L3
names: Similarity
messages: Belongs to the PHYHIP family.

9595:JRK
gene id: 9595:JRK
uniprot id: G3RQN3
names: Subcellular Location Annotation
messages: Nucleus

9595:RBKS
gene id: 9595:RBKS
uniprot id: G3R725
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9595:HOXA9
gene id: 9595:HOXA9
uniprot id: G3QIH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9595:KRT74
gene id: 9595:KRT74
uniprot id: G3QKU7
names: Similarity
messages: Belongs to the intermediate filament family.

9595:MCOLN2
gene id: 9595:MCOLN2
uniprot id: G3R915
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9595:CANX
gene id: 9595:CANX
uniprot id: G3RX20
names: Similarity
messages: Belongs to the calreticulin family.

9595:GDF3
gene id: 9595:GDF3
uniprot id: G3R9N1
names: Similarity
messages: Belongs to the TGF-beta family.

9595:CTBS
gene id: 9595:CTBS
uniprot id: G3RI64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Lysosome

9595:SPHKAP
gene id: 9595:SPHKAP
uniprot id: G3R5L9
names: Similarity
messages: Belongs to the AKAP110 family.

9595:SLC25A15
gene id: 9595:SLC25A15
uniprot id: G3S1F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:ZC3HC1
gene id: 9595:ZC3HC1
uniprot id: A0A2I2Z792
uniprot id: G3RHK2
names: Subcellular Location Annotation
messages: Nucleus

9595:MEOX2
gene id: 9595:MEOX2
uniprot id: G3QTT1
names: Subcellular Location Annotation
messages: Nucleus

9595:FEV
gene id: 9595:FEV
uniprot id: G3R5E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:TMEM123
gene id: 9595:TMEM123
uniprot id: G3QZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9595:GGT7
gene id: 9595:GGT7
uniprot id: G3RG66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9595:SNRPG
gene id: 9595:SNRPG
uniprot id: A0A2I2YEA9
uniprot id: A0A2I2Z4Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9595:SCNN1G
gene id: 9595:SCNN1G
uniprot id: G3QWQ8
names: Subcellular Location Annotation
messages: Membrane

9595:ACKR4
gene id: 9595:ACKR4
uniprot id: A0A2I2Y9C3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:HPSE2
gene id: 9595:HPSE2
uniprot id: A0A2I2ZBM5
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9595:PPP2R2B
gene id: 9595:PPP2R2B
uniprot id: A0A2I2YWE8
uniprot id: A0A2I2Z3T1
uniprot id: A0A2I2Z8R0
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9595:ST6GAL2
gene id: 9595:ST6GAL2
uniprot id: A0A2I2Z140
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

9595:LIPA
gene id: 9595:LIPA
uniprot id: G3QN03
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9595:ALOX12
gene id: 9595:ALOX12
uniprot id: G3R2S7
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RDH16
gene id: 9595:RDH16
uniprot id: G3RKU4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:BEX1
gene id: 9595:BEX1
uniprot id: G3SBZ1
names: Similarity
messages: Belongs to the BEX family.

9595:HLCS
gene id: 9595:HLCS
uniprot id: G3R6B1
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9595:LCK
gene id: 9595:LCK
uniprot id: G3QJD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9595:RIC3
gene id: 9595:RIC3
uniprot id: G3QME0
names: Similarity
messages: Belongs to the ric-3 family.

9595:KCNS2
gene id: 9595:KCNS2
uniprot id: G3QJZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:STK32B
gene id: 9595:STK32B
uniprot id: G3R3J6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:KLC4
gene id: 9595:KLC4
uniprot id: G3R4U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9595:CPOX
gene id: 9595:CPOX
uniprot id: G3REH3
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

9595:NAPSA
gene id: 9595:NAPSA
uniprot id: G3QK89
names: Similarity
messages: Belongs to the peptidase A1 family.

9595:SIM2
gene id: 9595:SIM2
uniprot id: A0A2I2Y3I5
names: Subcellular Location Annotation
messages: Nucleus

9595:SUGP1
gene id: 9595:SUGP1
uniprot id: G3QKG2
names: Subcellular Location Annotation
messages: Nucleus

9595:ZMYND10
gene id: 9595:ZMYND10
uniprot id: G3QW15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite

9595:KPNA6
gene id: 9595:KPNA6
uniprot id: A0A2I2YR04
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9595:RANBP10
gene id: 9595:RANBP10
uniprot id: G3RLS8
names: Similarity
messages: Belongs to the RANBP9/10 family.

9595:PPP1R1C
gene id: 9595:PPP1R1C
uniprot id: G3SHT3
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9595:CPEB4
gene id: 9595:CPEB4
uniprot id: A0A2I2Y9G1
uniprot id: A0A2I2Z0N7
uniprot id: A0A2I2Z1M3
uniprot id: G3R3M7
names: Similarity
messages: Belongs to the RRM CPEB family.

9595:UHRF1
gene id: 9595:UHRF1
uniprot id: G3RVG5
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

9595:NFXL1
gene id: 9595:NFXL1
uniprot id: G3QZI7
names: Similarity
messages: Belongs to the NFX1 family.

9595:LOC101130783
gene id: 9595:LOC101130783
uniprot id: G3QM00
names: Similarity
messages: Belongs to the TCAF family.

9595:MDM4
gene id: 9595:MDM4
uniprot id: G3RB06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

9595:PAX6
gene id: 9595:PAX6
uniprot id: A0A2I2ZFV9
uniprot id: G3RQQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9595:FAM167A
gene id: 9595:FAM167A
uniprot id: G3RJ13
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9595:LOC101152116
gene id: 9595:LOC101152116
uniprot id: G3RF92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ITGA2
gene id: 9595:ITGA2
uniprot id: G3QG21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:RECQL
gene id: 9595:RECQL
uniprot id: A0A2I2ZF50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9595:ADGRV1
gene id: 9595:ADGRV1
uniprot id: G3R5Z0
names: Subcellular Location Annotation
messages: Membrane

9595:WARS2
gene id: 9595:WARS2
uniprot id: G3RGC4
uniprot id: G3RVR3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:TMEM41B
gene id: 9595:TMEM41B
uniprot id: A0A2I2YMS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9595:ELF3
gene id: 9595:ELF3
uniprot id: G3RE61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:VPS72
gene id: 9595:VPS72
uniprot id: A0A2I2ZUZ9
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9595:CXCL13
gene id: 9595:CXCL13
uniprot id: G3RE10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:MAN1C1
gene id: 9595:MAN1C1
uniprot id: G3R750
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9595:DLK1
gene id: 9595:DLK1
uniprot id: G3QDU0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PNPT1
gene id: 9595:PNPT1
uniprot id: G3QVF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm

9595:PTCD2
gene id: 9595:PTCD2
uniprot id: G3R562
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

9595:NPTXR
gene id: 9595:NPTXR
uniprot id: G3SD80
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MAP2K1
gene id: 9595:MAP2K1
uniprot id: G3QM92
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:LAMB2
gene id: 9595:LAMB2
uniprot id: G3RG19
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9595:AQP6
gene id: 9595:AQP6
uniprot id: G3QSX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9595:CD53
gene id: 9595:CD53
uniprot id: G3QRU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:ATR
gene id: 9595:ATR
uniprot id: A0A2I2YTG6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.

9595:FAM83B
gene id: 9595:FAM83B
uniprot id: G3QIH2
names: Similarity
messages: Belongs to the FAM83 family.

9595:GJA5
gene id: 9595:GJA5
uniprot id: A0A2I2ZC67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:UCP3
gene id: 9595:UCP3
uniprot id: G3QDL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:MCM6
gene id: 9595:MCM6
uniprot id: A0A2I2ZI12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9595:PRIM1
gene id: 9595:PRIM1
uniprot id: G3RCL3
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9595:PPP1R13B
gene id: 9595:PPP1R13B
uniprot id: G3SBW5
names: Subcellular Location Annotation
messages: Nucleus

9595:MFSD14A
gene id: 9595:MFSD14A
uniprot id: G3QF32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9595:ICAM5
gene id: 9595:ICAM5
uniprot id: G3QT56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9595:CRAT
gene id: 9595:CRAT
uniprot id: G3RRT6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9595:GFM1
gene id: 9595:GFM1
uniprot id: G3QKQ5
uniprot id: G3S1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9595:VAX2
gene id: 9595:VAX2
uniprot id: G3QWH6
names: Subcellular Location Annotation
messages: Nucleus

9595:POU1F1
gene id: 9595:POU1F1
uniprot id: G3R8G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9595:SNRPE
gene id: 9595:SNRPE
uniprot id: A0A2I2ZKR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9595:IGF1R
gene id: 9595:IGF1R
uniprot id: G3RAQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9595:LOC101141650
gene id: 9595:LOC101141650
uniprot id: G3R102
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9595:CDH18
gene id: 9595:CDH18
uniprot id: G3R5X3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:HARS1
gene id: 9595:HARS1
uniprot id: G3RBJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9595:LOC101134144
gene id: 9595:LOC101134144
uniprot id: G3QFX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9595:MOCS2
gene id: 9595:MOCS2
uniprot id: G3QG23
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9595:HNF4A
gene id: 9595:HNF4A
uniprot id: G3QVQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:GALNT3
gene id: 9595:GALNT3
uniprot id: A0A2I2ZSP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:SEPTIN6
gene id: 9595:SEPTIN6
uniprot id: A0A2I2YF25
uniprot id: A0A2I2YIA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9595:IL1F10
gene id: 9595:IL1F10
uniprot id: G3R1W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9595:LOC101137477
gene id: 9595:LOC101137477
uniprot id: G3RZV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TBP
gene id: 9595:TBP
uniprot id: G3R850
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9595:SFXN2
gene id: 9595:SFXN2
uniprot id: G3R1U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9595:GNG13
gene id: 9595:GNG13
uniprot id: A0A2I2YWI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9595:ETV7
gene id: 9595:ETV7
uniprot id: A0A2I2YSH2
uniprot id: G3RPE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:OTX2
gene id: 9595:OTX2
uniprot id: G3QN58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9595:NOS2
gene id: 9595:NOS2
uniprot id: G3RR01
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

9595:DNTTIP2
gene id: 9595:DNTTIP2
uniprot id: G3RRP0
names: Subcellular Location Annotation
messages: nucleolus

9595:RFC1
gene id: 9595:RFC1
uniprot id: G3RXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

9595:LOC109023730
gene id: 9595:LOC109023730
uniprot id: G3RSH0
names: Similarity
messages: Belongs to the ATG8 family.

9595:CHRNA2
gene id: 9595:CHRNA2
uniprot id: G3RHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:LAGE3
gene id: 9595:LAGE3
uniprot id: G3RCE7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9595:ZFP36
gene id: 9595:ZFP36
uniprot id: G3REP8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9595:CZIB
gene id: 9595:CZIB
uniprot id: G3QN47
names: Similarity
messages: Belongs to the UPF0587 family.

9595:PRPSAP1
gene id: 9595:PRPSAP1
uniprot id: G3SKM1
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9595:REEP3
gene id: 9595:REEP3
uniprot id: G3RNL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9595:DTD1
gene id: 9595:DTD1
uniprot id: G3QCX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

9595:FKRP
gene id: 9595:FKRP
uniprot id: A0A2I2ZR51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9595:CAMP
gene id: 9595:CAMP
uniprot id: A0A2K5TIY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).
messages: Secreted
messages: Vesicle

9595:CD244
gene id: 9595:CD244
uniprot id: G3QS67
names: Subcellular Location Annotation
messages: Membrane

9595:PIH1D1
gene id: 9595:PIH1D1
uniprot id: G3RU31
names: Similarity
messages: Belongs to the PIH1 family.

9595:YJU2B
gene id: 9595:YJU2B
uniprot id: G3QUS3
names: Similarity
messages: Belongs to the CWC16 family.

9595:PFKM
gene id: 9595:PFKM
uniprot id: G3QUC7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:BTN2A2
gene id: 9595:BTN2A2
uniprot id: A0A2I2ZXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9595:BANF2
gene id: 9595:BANF2
uniprot id: G3QQ95
names: Subcellular Location Annotation
messages: Nucleus

9595:HNMT
gene id: 9595:HNMT
uniprot id: G3R7E5
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9595:DLX3
gene id: 9595:DLX3
uniprot id: G3RG95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9595:KIF17
gene id: 9595:KIF17
uniprot id: G3RF78
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:COPS8
gene id: 9595:COPS8
uniprot id: A0A2I2ZLE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9595:SH3GLB1
gene id: 9595:SH3GLB1
uniprot id: A0A2I2YIS4
uniprot id: A0A2I2YMI0
uniprot id: A0A2I2Z1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9595:TNFAIP3
gene id: 9595:TNFAIP3
uniprot id: G3QLD1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:TMEM14B
gene id: 9595:TMEM14B
uniprot id: A0A2I2Y4V8
uniprot id: A0A2I2ZCS9
names: Similarity
messages: Belongs to the TMEM14 family.

9595:RAP2B
gene id: 9595:RAP2B
uniprot id: A0A2I2Z1X2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9595:PRKACB
gene id: 9595:PRKACB
uniprot id: A0A2I2Z6Y0
uniprot id: A0A2I2ZBE7
uniprot id: A0A2I2ZC53
uniprot id: A0A2I2ZDX1
uniprot id: G3SC72
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9595:CCNT2
gene id: 9595:CCNT2
uniprot id: A0A2I2YB05
uniprot id: A0A2I2YFM0
names: Similarity
messages: Belongs to the cyclin family.

9595:CCNC
gene id: 9595:CCNC
uniprot id: A0A2I2YSZ3
uniprot id: G3QWU6
names: Similarity
messages: Belongs to the cyclin family.

9595:SHROOM2
gene id: 9595:SHROOM2
uniprot id: A0A2I2Y6Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9595:GATAD2A
gene id: 9595:GATAD2A
uniprot id: G3S585
names: Subcellular Location Annotation
messages: Nucleus

9595:PPP5C
gene id: 9595:PPP5C
uniprot id: G3QX73
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

9595:TSR1
gene id: 9595:TSR1
uniprot id: G3QH58
names: Subcellular Location Annotation
messages: nucleolus

9595:TUBE1
gene id: 9595:TUBE1
uniprot id: G3QQD6
names: Similarity
messages: Belongs to the tubulin family.

9595:CD40LG
gene id: 9595:CD40LG
uniprot id: A0A2I2YT93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

9595:COPE
gene id: 9595:COPE
uniprot id: G3QVQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9595:IRX1
gene id: 9595:IRX1
uniprot id: G3SJC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9595:DLGAP5
gene id: 9595:DLGAP5
uniprot id: A0A2I2ZGM2
uniprot id: G3QLP8
names: Similarity
messages: Belongs to the SAPAP family.

9595:SOAT2
gene id: 9595:SOAT2
uniprot id: G3QKW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:NNT
gene id: 9595:NNT
uniprot id: G3QRV0
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9595:USP48
gene id: 9595:USP48
uniprot id: G3RU24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

9595:PSMB2
gene id: 9595:PSMB2
uniprot id: G3SJ48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:CHRNG
gene id: 9595:CHRNG
uniprot id: G3QI66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:DDX52
gene id: 9595:DDX52
uniprot id: G3S4T6
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9595:NACC1
gene id: 9595:NACC1
uniprot id: G3SJX3
names: Subcellular Location Annotation
messages: Nucleus

9595:TMEM94
gene id: 9595:TMEM94
uniprot id: G3RUP2
uniprot id: G3SCJ5
names: Subcellular Location Annotation
messages: Membrane

9595:TMC3
gene id: 9595:TMC3
uniprot id: G3QR19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9595:HTATIP2
gene id: 9595:HTATIP2
uniprot id: A1YER2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA (By similarity).
messages: Nucleus envelope
messages: Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import (By similarity).

9595:PDCL2
gene id: 9595:PDCL2
uniprot id: G3QY16
names: Similarity
messages: Belongs to the phosducin family.

9595:SOX21
gene id: 9595:SOX21
uniprot id: G3RV32
names: Subcellular Location Annotation
messages: Nucleus

9595:PANX3
gene id: 9595:PANX3
uniprot id: G3QMD9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9595:DDX41
gene id: 9595:DDX41
uniprot id: G3REY5
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

9595:ERF
gene id: 9595:ERF
uniprot id: G3QPR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:SMIM15
gene id: 9595:SMIM15
uniprot id: A0A2I2Y3E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9595:POLG2
gene id: 9595:POLG2
uniprot id: G3RHB8
names: Subcellular Location Annotation
messages: Mitochondrion

9595:NR0B1
gene id: 9595:NR0B1
uniprot id: G3QIY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9595:XPO7
gene id: 9595:XPO7
uniprot id: A0A2I2Z687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9595:CD22
gene id: 9595:CD22
uniprot id: Q9N1E4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
messages: Cell membrane
messages: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
messages: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid (By similarity). Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules.
messages: Phosphorylated on tyrosine residues by LYN.
messages: Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
messages: Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1 (By similarity).

9595:ATP7A
gene id: 9595:ATP7A
uniprot id: G3S1J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9595:ECSIT
gene id: 9595:ECSIT
uniprot id: A0A2I2YBD8
uniprot id: A0A2I2YNV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

9595:MRTO4
gene id: 9595:MRTO4
uniprot id: G3QE40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9595:NUP35
gene id: 9595:NUP35
uniprot id: G3R368
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9595:LOC101151732
gene id: 9595:LOC101151732
uniprot id: Q6LDH0
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.
messages: Red blood cells.
messages: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

9595:ARMC10
gene id: 9595:ARMC10
uniprot id: A0A2I2ZST0
uniprot id: G3QH76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9595:LOC101137637
gene id: 9595:LOC101137637
uniprot id: G3RF00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CENPB
gene id: 9595:CENPB
uniprot id: A0A2I2ZG27
names: Subcellular Location Annotation
messages: Nucleus

9595:NAPG
gene id: 9595:NAPG
uniprot id: G3RHC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9595:DNAL4
gene id: 9595:DNAL4
uniprot id: G3RCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9595:RUNX1T1
gene id: 9595:RUNX1T1
uniprot id: A0A2I2Y379
uniprot id: A0A2I2ZGA4
uniprot id: A0A2I2ZQG2
names: Similarity
messages: Belongs to the CBFA2T family.

9595:KRT13
gene id: 9595:KRT13
uniprot id: G3RL36
names: Similarity
messages: Belongs to the intermediate filament family.

9595:PTPN2
gene id: 9595:PTPN2
uniprot id: A0A2I2Y272
uniprot id: G3RMA5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9595:KIF21A
gene id: 9595:KIF21A
uniprot id: A0A2I2YP88
uniprot id: G3RU75
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:RAB3IP
gene id: 9595:RAB3IP
uniprot id: G3QZA3
uniprot id: G3RR29
names: Similarity
messages: Belongs to the SEC2 family.

9595:CAMK1G
gene id: 9595:CAMK1G
uniprot id: G3QFX0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:DBT
gene id: 9595:DBT
uniprot id: G3S1Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9595:SET
gene id: 9595:SET
uniprot id: G3S4E1
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9595:NELFCD
gene id: 9595:NELFCD
uniprot id: G3QV15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

9595:NCK2
gene id: 9595:NCK2
uniprot id: G3RFN5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9595:FAM174C
gene id: 9595:FAM174C
uniprot id: G3S6U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9595:RNASE7
gene id: 9595:RNASE7
uniprot id: A0A2I2YVV3
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9595:DDRGK1
gene id: 9595:DDRGK1
uniprot id: G3R061
names: Similarity
messages: Belongs to the DDRGK1 family.

9595:PSMD1
gene id: 9595:PSMD1
uniprot id: G3RVS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9595:GIMAP4
gene id: 9595:GIMAP4
uniprot id: G3QIU6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9595:FAM24B
gene id: 9595:FAM24B
uniprot id: G3QW84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM24 family.
messages: Secreted

9595:LOC101143893
gene id: 9595:LOC101143893
uniprot id: G3QJG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9595:NRXN2
gene id: 9595:NRXN2
uniprot id: A0A2I2Y2T6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TIE1
gene id: 9595:TIE1
uniprot id: G3R075
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SLC14A2
gene id: 9595:SLC14A2
uniprot id: G3QFG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9595:PNPO
gene id: 9595:PNPO
uniprot id: A0A2I2YWE4
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

9595:PIGU
gene id: 9595:PIGU
uniprot id: G3QU94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:SLC35F4
gene id: 9595:SLC35F4
uniprot id: A0A2I2YY71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9595:LDLRAD3
gene id: 9595:LDLRAD3
uniprot id: G3RKF8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ANAPC2
gene id: 9595:ANAPC2
uniprot id: G3RV64
names: Similarity
messages: Belongs to the cullin family.

9595:GRHL2
gene id: 9595:GRHL2
uniprot id: G3SG69
names: Subcellular Location Annotation
messages: Nucleus

9595:SST
gene id: 9595:SST
uniprot id: G3S1J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9595:MED28
gene id: 9595:MED28
uniprot id: G3QFM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9595:BLOC1S1
gene id: 9595:BLOC1S1
uniprot id: G3QKX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space

9595:NOSTRIN
gene id: 9595:NOSTRIN
uniprot id: G3RPD3
names: Subcellular Location Annotation
messages: cytoskeleton

9595:ERLIN1
gene id: 9595:ERLIN1
uniprot id: G3R4T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9595:ATP6AP2
gene id: 9595:ATP6AP2
uniprot id: G3S9T4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9595:ABHD2
gene id: 9595:ABHD2
uniprot id: G3R7Q2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9595:ATP1A3
gene id: 9595:ATP1A3
uniprot id: G3QT34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9595:TPPP3
gene id: 9595:TPPP3
uniprot id: G3QZH6
names: Similarity
messages: Belongs to the TPPP family.

9595:PIP
gene id: 9595:PIP
uniprot id: A0A885
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1 (By similarity).
messages: Secreted

9595:UCK2
gene id: 9595:UCK2
uniprot id: A0A2I2YXB8
names: Similarity
messages: Belongs to the uridine kinase family.

9595:GSK3B
gene id: 9595:GSK3B
uniprot id: A0A2I2Y1S1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9595:BEST3
gene id: 9595:BEST3
uniprot id: A0A2I2YBH8
uniprot id: A0A2I2ZK62
uniprot id: G3R1I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9595:SLC16A11
gene id: 9595:SLC16A11
uniprot id: G3QG12
names: Subcellular Location Annotation
messages: Membrane

9595:NIPAL1
gene id: 9595:NIPAL1
uniprot id: A0A2I2YE80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9595:QRSL1
gene id: 9595:QRSL1
uniprot id: G3SBQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9595:LOC101128369
gene id: 9595:LOC101128369
uniprot id: G3QFB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9595:NDST1
gene id: 9595:NDST1
uniprot id: G3RCY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9595:FUCA1
gene id: 9595:FUCA1
uniprot id: G3QV26
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9595:CXCL11
gene id: 9595:CXCL11
uniprot id: A0A2I2YQQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:INTS3
gene id: 9595:INTS3
uniprot id: G3RTH1
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9595:PTPN6
gene id: 9595:PTPN6
uniprot id: G3QNS0
uniprot id: G3RE40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9595:FLT1
gene id: 9595:FLT1
uniprot id: A0A2I2ZNE7
uniprot id: G3SHN4
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

9595:DUSP1
gene id: 9595:DUSP1
uniprot id: G3QW32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9595:RAB3IL1
gene id: 9595:RAB3IL1
uniprot id: G3RMA9
names: Similarity
messages: Belongs to the SEC2 family.

9595:HBQ1
gene id: 9595:HBQ1
uniprot id: G3RJU5
names: Similarity
messages: Belongs to the globin family.

9595:SLIT2
gene id: 9595:SLIT2
uniprot id: A0A2I2Z9V9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:GABRG1
gene id: 9595:GABRG1
uniprot id: A0A2I2ZBY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:ALKBH6
gene id: 9595:ALKBH6
uniprot id: A0A2I2ZG06
uniprot id: A0A2I2ZR67
names: Similarity
messages: Belongs to the alkB family.

9595:SHTN1
gene id: 9595:SHTN1
uniprot id: A0A2I2YTM9
uniprot id: G3SI42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: Perikaryon
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9595:GOLM1
gene id: 9595:GOLM1
uniprot id: G3R9T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9595:PFKFB4
gene id: 9595:PFKFB4
uniprot id: G3R5N0
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9595:AP5M1
gene id: 9595:AP5M1
uniprot id: G3QSF9
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9595:NPFFR2
gene id: 9595:NPFFR2
uniprot id: G3R6B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9595:LOC101129773
gene id: 9595:LOC101129773
uniprot id: A0A2I2ZQM8
uniprot id: G3QXG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9595:NDUFV1
gene id: 9595:NDUFV1
uniprot id: Q0MQI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 51 kDa subunit family.
messages: Binds 1 FMN.
messages: Binds 1 [4Fe-4S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity). Interacts with RAB5IF (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Mitochondrion inner membrane

9595:ACTR10
gene id: 9595:ACTR10
uniprot id: G3QVF4
names: Similarity
messages: Belongs to the actin family.

9595:LMNA
gene id: 9595:LMNA
uniprot id: G3QEU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9595:COQ10A
gene id: 9595:COQ10A
uniprot id: G3R133
uniprot id: G3S4I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9595:HMGCS1
gene id: 9595:HMGCS1
uniprot id: G3QFP6
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9595:TBX3
gene id: 9595:TBX3
uniprot id: A0A2I2YWL2
uniprot id: G3QNP1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:CDC14A
gene id: 9595:CDC14A
uniprot id: A0A2I2YAS9
uniprot id: A0A2I2Z2L9
uniprot id: A0A2I2Z754
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9595:SERPING1
gene id: 9595:SERPING1
uniprot id: G3RHZ3
names: Similarity
messages: Belongs to the serpin family.

9595:LPIN2
gene id: 9595:LPIN2
uniprot id: G3QDK3
names: Similarity
messages: Belongs to the lipin family.

9595:IPO13
gene id: 9595:IPO13
uniprot id: G3RJT7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9595:KBTBD8
gene id: 9595:KBTBD8
uniprot id: G3RYR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9595:RIOX2
gene id: 9595:RIOX2
uniprot id: A0A2I2Z0X2
uniprot id: G3RJE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. MINA53 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.

9595:LOC101151536
gene id: 9595:LOC101151536
uniprot id: G3R3H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9595:SLC4A10
gene id: 9595:SLC4A10
uniprot id: A0A2I2ZDH3
uniprot id: G3S614
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9595:CCL23
gene id: 9595:CCL23
uniprot id: G3QLY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:TMEM86B
gene id: 9595:TMEM86B
uniprot id: G3QRI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9595:ARPIN
gene id: 9595:ARPIN
uniprot id: A0A2I2ZMV0
names: Similarity
messages: Belongs to the Arpin family.

9595:ABCC3
gene id: 9595:ABCC3
uniprot id: G3QLJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9595:FGFBP2
gene id: 9595:FGFBP2
uniprot id: G3S6Y9
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9595:LOC101142758
gene id: 9595:LOC101142758
uniprot id: G3QK98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9595:SNX13
gene id: 9595:SNX13
uniprot id: A0A2I2YC30
names: Similarity
messages: Belongs to the sorting nexin family.

9595:EIF2B2
gene id: 9595:EIF2B2
uniprot id: G3QE21
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9595:LOC101140761
gene id: 9595:LOC101140761
uniprot id: G3SFL0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:PMEL
gene id: 9595:PMEL
uniprot id: G3RDU4
names: Similarity
messages: Belongs to the PMEL/NMB family.

9595:DDX54
gene id: 9595:DDX54
uniprot id: G3R4G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

9595:CPPED1
gene id: 9595:CPPED1
uniprot id: A0A2I2Y3C8
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9595:FHL5
gene id: 9595:FHL5
uniprot id: G3QNM5
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9595:SPTBN1
gene id: 9595:SPTBN1
uniprot id: A0A2I2ZWA3
names: Similarity
messages: Belongs to the spectrin family.

9595:COQ4
gene id: 9595:COQ4
uniprot id: G3RFQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9595:FMNL1
gene id: 9595:FMNL1
uniprot id: A0A2I2YLV3
names: Similarity
messages: Belongs to the formin homology family.

9595:ERCC4
gene id: 9595:ERCC4
uniprot id: G3REB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9595:SGMS2
gene id: 9595:SGMS2
uniprot id: G3RA31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9595:LOC101134469
gene id: 9595:LOC101134469
uniprot id: G3RXT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:GDF10
gene id: 9595:GDF10
uniprot id: G3QSX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9595:VPS37B
gene id: 9595:VPS37B
uniprot id: G3QQI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:KRT15
gene id: 9595:KRT15
uniprot id: A0A2I2Z0J1
names: Similarity
messages: Belongs to the intermediate filament family.

9595:ATP6V1B1
gene id: 9595:ATP6V1B1
uniprot id: A0A2I2YJ09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9595:PARP9
gene id: 9595:PARP9
uniprot id: G3RIR3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:FOXN1
gene id: 9595:FOXN1
uniprot id: G3R2K4
names: Subcellular Location Annotation
messages: Nucleus

9595:SSRP1
gene id: 9595:SSRP1
uniprot id: G3R9I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9595:QNG1
gene id: 9595:QNG1
uniprot id: G3R6P5
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

9595:STC2
gene id: 9595:STC2
uniprot id: G3RD02
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9595:SH3BGRL2
gene id: 9595:SH3BGRL2
uniprot id: G3RR85
names: Similarity
messages: Belongs to the SH3BGR family.

9595:ARHGEF3
gene id: 9595:ARHGEF3
uniprot id: A0A2I2ZAZ4
uniprot id: A0A2I2ZTX9
uniprot id: G3QEG3
uniprot id: G3SD09
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9595:MX2
gene id: 9595:MX2
uniprot id: G3QGS2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9595:PAX3
gene id: 9595:PAX3
uniprot id: A0A2I2Y6N5
uniprot id: G3SAM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9595:ALG8
gene id: 9595:ALG8
uniprot id: G3R7I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:APLN
gene id: 9595:APLN
uniprot id: A0A2I2Z1U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apelin family.
messages: extracellular space

9595:SEMA3C
gene id: 9595:SEMA3C
uniprot id: G3RJN2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:PAMR1
gene id: 9595:PAMR1
uniprot id: G3REC8
uniprot id: G3RYC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:EMC2
gene id: 9595:EMC2
uniprot id: G3RR20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

9595:LOC101125083
gene id: 9595:LOC101125083
uniprot id: A0A2I2ZAH3
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9595:ZSCAN5C
gene id: 9595:ZSCAN5C
uniprot id: G3RDY2
names: Subcellular Location Annotation
messages: Nucleus

9595:ELAC1
gene id: 9595:ELAC1
uniprot id: G3QJI8
names: Subunit
messages: Homodimer.

9595:NUDT1
gene id: 9595:NUDT1
uniprot id: G3RNY0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

9595:GNAL
gene id: 9595:GNAL
uniprot id: G3RIY2
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9595:CD79A
gene id: 9595:CD79A
uniprot id: G3RGZ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:CAMK1
gene id: 9595:CAMK1
uniprot id: G3RED6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:KCNJ6
gene id: 9595:KCNJ6
uniprot id: A0A2I2YHE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9595:AVPR1A
gene id: 9595:AVPR1A
uniprot id: A0A2I2Z9B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9595:LOC101142986
gene id: 9595:LOC101142986
uniprot id: G3RN90
names: Subcellular Location Annotation
messages: Membrane

9595:SCAND1
gene id: 9595:SCAND1
uniprot id: A0A2K5TIX9
names: Subcellular Location Annotation
messages: Nucleus

9595:VPS26B
gene id: 9595:VPS26B
uniprot id: G3QV91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9595:ZC3H15
gene id: 9595:ZC3H15
uniprot id: G3QCX0
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9595:MRPL17
gene id: 9595:MRPL17
uniprot id: A0A2I2Z344
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9595:INHBE
gene id: 9595:INHBE
uniprot id: G3QJX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9595:ZNF274
gene id: 9595:ZNF274
uniprot id: G3RTC3
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101154074
gene id: 9595:LOC101154074
uniprot id: G3R2L4
names: Similarity
messages: Belongs to the intermediate filament family.

9595:BTBD10
gene id: 9595:BTBD10
uniprot id: G3QDD1
uniprot id: G3RXU9
names: Subcellular Location Annotation
messages: Cytoplasm

9595:TSSC4
gene id: 9595:TSSC4
uniprot id: G3QX83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TSSC4 family.
messages: Cytoplasm
messages: Nucleus

9595:XPA
gene id: 9595:XPA
uniprot id: A0A2I2Y279
uniprot id: G3QGB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9595:TMEM170B
gene id: 9595:TMEM170B
uniprot id: G3QUA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9595:RGS2
gene id: 9595:RGS2
uniprot id: G3QJV6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: nucleolus

9595:OTOF
gene id: 9595:OTOF
uniprot id: G3RZU3
names: Similarity
messages: Belongs to the ferlin family.

9595:CFAP126
gene id: 9595:CFAP126
uniprot id: G3QYB5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9595:MINPP1
gene id: 9595:MINPP1
uniprot id: G3QWU7
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

9595:PSMB3
gene id: 9595:PSMB3
uniprot id: G3QVX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:ABAT
gene id: 9595:ABAT
uniprot id: G3R3N6
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9595:LOC101128557
gene id: 9595:LOC101128557
uniprot id: G3S5D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:HVCN1
gene id: 9595:HVCN1
uniprot id: G3QN52
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9595:PARP14
gene id: 9595:PARP14
uniprot id: G3S362
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:PDGFRL
gene id: 9595:PDGFRL
uniprot id: G3REV5
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

9595:ENTREP3
gene id: 9595:ENTREP3
uniprot id: A0A2I2Z2I4
uniprot id: G3R1X5
names: Similarity
messages: Belongs to the ENTREP family.

9595:LGI2
gene id: 9595:LGI2
uniprot id: G3S4D7
names: Subcellular Location Annotation
messages: Secreted

9595:XRCC6
gene id: 9595:XRCC6
uniprot id: G3RIJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

9595:LOC101131235
gene id: 9595:LOC101131235
uniprot id: G3S117
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Endosome membrane
messages: Lysosome membrane

9595:CMC1
gene id: 9595:CMC1
uniprot id: A0A2I2Y7L1
uniprot id: G3R9L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9595:ORMDL1
gene id: 9595:ORMDL1
uniprot id: G3RGX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9595:RUNX1
gene id: 9595:RUNX1
uniprot id: A0A2I2YIQ6
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9595:THBS3
gene id: 9595:THBS3
uniprot id: G3R1N5
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:IGFL1
gene id: 9595:IGFL1
uniprot id: G3R747
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IGFL family.
messages: Secreted

9595:SLC5A1
gene id: 9595:SLC5A1
uniprot id: G3SHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9595:EMC3
gene id: 9595:EMC3
uniprot id: A0A2I2ZL94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9595:FBXO34
gene id: 9595:FBXO34
uniprot id: G3QVE0
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9595:LOC101136323
gene id: 9595:LOC101136323
uniprot id: A0A2I2ZUI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:XKR5
gene id: 9595:XKR5
uniprot id: A0A2I2YUT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9595:PLAC8
gene id: 9595:PLAC8
uniprot id: G3QWX8
names: Similarity
messages: Belongs to the cornifelin family.

9595:SERBP1
gene id: 9595:SERBP1
uniprot id: G3R4E0
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

9595:PDE2A
gene id: 9595:PDE2A
uniprot id: A0A2I2Z1G1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:FOXB2
gene id: 9595:FOXB2
uniprot id: A0A2I2ZRB3
names: Subcellular Location Annotation
messages: Nucleus

9595:SRPRB
gene id: 9595:SRPRB
uniprot id: G3SG96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:GATA1
gene id: 9595:GATA1
uniprot id: G3RS51
names: Subcellular Location Annotation
messages: Nucleus

9595:INHA
gene id: 9595:INHA
uniprot id: G3QM12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9595:LOC101125223
gene id: 9595:LOC101125223
uniprot id: A4H1Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria.
messages: Secreted

9595:LOC101133280
gene id: 9595:LOC101133280
uniprot id: A0A2I2Y3I3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:NR1D1
gene id: 9595:NR1D1
uniprot id: G3R2J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:SHROOM1
gene id: 9595:SHROOM1
uniprot id: G3SF06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9595:HACL1
gene id: 9595:HACL1
uniprot id: G3R5G3
names: Similarity
messages: Belongs to the TPP enzyme family.

9595:HOXB2
gene id: 9595:HOXB2
uniprot id: G3R360
names: Subcellular Location Annotation
messages: Nucleus

9595:HMGN3
gene id: 9595:HMGN3
uniprot id: G3SDN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9595:RPS25
gene id: 9595:RPS25
uniprot id: A0A2I2ZJ21
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the small ribosomal subunit.

9595:UTP23
gene id: 9595:UTP23
uniprot id: A0A2I2YP15
names: Subcellular Location Annotation
messages: nucleolus

9595:BLOC1S2
gene id: 9595:BLOC1S2
uniprot id: A0A2I2Z9W6
uniprot id: A0A2I2ZX77
names: Similarity
messages: Belongs to the BLOC1S2 family.

9595:RFTN1
gene id: 9595:RFTN1
uniprot id: G3R0K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9595:TCEA1
gene id: 9595:TCEA1
uniprot id: G3S7T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9595:SEMA3D
gene id: 9595:SEMA3D
uniprot id: G3RA65
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TOR3A
gene id: 9595:TOR3A
uniprot id: A0A2I2ZGQ9
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9595:RPRD1B
gene id: 9595:RPRD1B
uniprot id: G3QNP7
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9595:BOK
gene id: 9595:BOK
uniprot id: A0A2I2ZF28
names: Similarity
messages: Belongs to the Bcl-2 family.

9595:ITIH1
gene id: 9595:ITIH1
uniprot id: G3QSH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9595:KDM3B
gene id: 9595:KDM3B
uniprot id: G3QEW8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9595:FHIP1A
gene id: 9595:FHIP1A
uniprot id: G3RKA8
names: Similarity
messages: Belongs to the FHIP family.

9595:LOC101153071
gene id: 9595:LOC101153071
uniprot id: G3QVI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9595:YPEL5
gene id: 9595:YPEL5
uniprot id: G3S733
names: Similarity
messages: Belongs to the yippee family.

9595:NDUFS3
gene id: 9595:NDUFS3
uniprot id: Q0MQG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). Interacts with NDUFAF3 (By similarity). Interacts with RAB5IF (By similarity). Found in subcomplexes containing subunits NDUFS2, MT-ND1 and NDUFA13 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity).
messages: Mitochondrion inner membrane

9595:IFI30
gene id: 9595:IFI30
uniprot id: G3R964
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

9595:ZSCAN9
gene id: 9595:ZSCAN9
uniprot id: A0A2I2Y5J7
names: Subcellular Location Annotation
messages: Nucleus

9595:DNAJA1
gene id: 9595:DNAJA1
uniprot id: G3QVU3
names: Subcellular Location Annotation
messages: Membrane

9595:NELL2
gene id: 9595:NELL2
uniprot id: A0A2I2Y6W4
uniprot id: A0A2I2Z2V4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101147054
gene id: 9595:LOC101147054
uniprot id: G3QSH7
names: Subcellular Location Annotation
messages: Membrane

9595:MBL2
gene id: 9595:MBL2
uniprot id: Q66S60
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
messages: Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
messages: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).
messages: Secreted
messages: The coiled-coil domain mediates trimerization.

9595:FGFR2
gene id: 9595:FGFR2
uniprot id: A0A2I2ZVK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:C15H15orf40
gene id: 9595:C15H15orf40
uniprot id: G3RPN2
names: Similarity
messages: Belongs to the UPF0235 family.

9595:AARS2
gene id: 9595:AARS2
uniprot id: G3QRY8
names: Caution
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9595:PMS1
gene id: 9595:PMS1
uniprot id: A0A2I2Y7B3
uniprot id: A0A2I2ZTS4
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9595:EDN3
gene id: 9595:EDN3
uniprot id: G3RAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9595:ACTL8
gene id: 9595:ACTL8
uniprot id: G3RFH6
names: Similarity
messages: Belongs to the actin family.

9595:EXOSC8
gene id: 9595:EXOSC8
uniprot id: G3R8A9
names: Subcellular Location Annotation
messages: Cytoplasm

9595:CXCR5
gene id: 9595:CXCR5
uniprot id: G3RDW5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:ZIC1
gene id: 9595:ZIC1
uniprot id: G3SI03
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9595:EMX2
gene id: 9595:EMX2
uniprot id: G3RKJ4
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101131824
gene id: 9595:LOC101131824
uniprot id: G3S4C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TRARG1
gene id: 9595:TRARG1
uniprot id: G3SCX6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:DMBX1
gene id: 9595:DMBX1
uniprot id: G3R8Q8
names: Subcellular Location Annotation
messages: Nucleus

9595:RFT1
gene id: 9595:RFT1
uniprot id: A0A2I2YZP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

9595:PLA2G4A
gene id: 9595:PLA2G4A
uniprot id: G3R9G5
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9595:SIDT2
gene id: 9595:SIDT2
uniprot id: G3SJA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9595:DRAM2
gene id: 9595:DRAM2
uniprot id: G3R2A4
names: Subcellular Location Annotation
messages: Membrane

9595:MTMR2
gene id: 9595:MTMR2
uniprot id: G3RYF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9595:OTULIN
gene id: 9595:OTULIN
uniprot id: A0A2I2Z0M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9595:EPHA7
gene id: 9595:EPHA7
uniprot id: G3QUG2
names: Subcellular Location Annotation
messages: Membrane

9595:CDO1
gene id: 9595:CDO1
uniprot id: G3RJL8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9595:PRKCE
gene id: 9595:PRKCE
uniprot id: G3R8H1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

9595:AVIL
gene id: 9595:AVIL
uniprot id: G3QGE5
names: Similarity
messages: Belongs to the villin/gelsolin family.

9595:MCEE
gene id: 9595:MCEE
uniprot id: G3RZF8
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9595:KCNK9
gene id: 9595:KCNK9
uniprot id: A0A2I2ZP69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9595:CTPS2
gene id: 9595:CTPS2
uniprot id: G3QVM9
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9595:AZIN2
gene id: 9595:AZIN2
uniprot id: G3RFZ8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9595:LOC101141171
gene id: 9595:LOC101141171
uniprot id: G3RI60
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9595:GOT1
gene id: 9595:GOT1
uniprot id: G3QJC1
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9595:APEH
gene id: 9595:APEH
uniprot id: G3R4V3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.

9595:P2RY4
gene id: 9595:P2RY4
uniprot id: G3QEC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ST6GALNAC1
gene id: 9595:ST6GALNAC1
uniprot id: G3QCR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:LOC101133462
gene id: 9595:LOC101133462
uniprot id: G3R477
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:IGFBP4
gene id: 9595:IGFBP4
uniprot id: G3R338
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:KRR1
gene id: 9595:KRR1
uniprot id: G3RCN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9595:SUCLG1
gene id: 9595:SUCLG1
uniprot id: G3QI12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9595:CDH7
gene id: 9595:CDH7
uniprot id: G3R6F1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:HOMEZ
gene id: 9595:HOMEZ
uniprot id: G3QIF1
names: Subcellular Location Annotation
messages: Nucleus

9595:KDSR
gene id: 9595:KDSR
uniprot id: G3RBX4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:MOSPD1
gene id: 9595:MOSPD1
uniprot id: A0A2I2YJN6
uniprot id: G3QMM4
names: Subcellular Location Annotation
messages: Membrane

9595:RIOK2
gene id: 9595:RIOK2
uniprot id: G3RZ18
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9595:ACO2
gene id: 9595:ACO2
uniprot id: G3QFL5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

9595:FDFT1
gene id: 9595:FDFT1
uniprot id: A0A2I2YI48
uniprot id: G3QFR9
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9595:ATP8A1
gene id: 9595:ATP8A1
uniprot id: A0A2I2ZP07
uniprot id: G3SEF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9595:LOC101144727
gene id: 9595:LOC101144727
uniprot id: G3QWL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9595:IGF2BP1
gene id: 9595:IGF2BP1
uniprot id: A0A2I2Z4W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9595:GSDME
gene id: 9595:GSDME
uniprot id: G3QR26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9595:YTHDF3
gene id: 9595:YTHDF3
uniprot id: A0A2I2YIF6
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9595:MRPL27
gene id: 9595:MRPL27
uniprot id: G3SCT0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9595:POU6F1
gene id: 9595:POU6F1
uniprot id: G3QDB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9595:ADAMTS18
gene id: 9595:ADAMTS18
uniprot id: G3SKG9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:RTN3
gene id: 9595:RTN3
uniprot id: A0A2I2YL16
uniprot id: A0A2I2Z8W7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:TRPC4
gene id: 9595:TRPC4
uniprot id: G3QW39
names: Subcellular Location Annotation
messages: Membrane

9595:DMRT1
gene id: 9595:DMRT1
uniprot id: G3S0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9595:FAM229B
gene id: 9595:FAM229B
uniprot id: G3RG91
names: Similarity
messages: Belongs to the FAM229 family.

9595:PROZ
gene id: 9595:PROZ
uniprot id: G3QDS4
uniprot id: G3SHG4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:AQP4
gene id: 9595:AQP4
uniprot id: G3R4L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9595:MAGOHB
gene id: 9595:MAGOHB
uniprot id: A0A2I2Y2C4
uniprot id: A0A2I2YIF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9595:FGD6
gene id: 9595:FGD6
uniprot id: A0A2I2Y251
names: Subcellular Location Annotation
messages: cytoskeleton

9595:NUS1
gene id: 9595:NUS1
uniprot id: G3SFP4
names: Similarity
messages: Belongs to the UPP synthase family.

9595:PNPLA6
gene id: 9595:PNPLA6
uniprot id: A0A2I2ZTV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LIPC
gene id: 9595:LIPC
uniprot id: G3QYK3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:RPL30
gene id: 9595:RPL30
uniprot id: G3QRX3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9595:SPDEF
gene id: 9595:SPDEF
uniprot id: G3QDQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:HAUS3
gene id: 9595:HAUS3
uniprot id: G3QEN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9595:PLXNB3
gene id: 9595:PLXNB3
uniprot id: A0A2I2YXF1
uniprot id: G3RNG4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:IL21
gene id: 9595:IL21
uniprot id: G3QY93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9595:C5H5orf63
gene id: 9595:C5H5orf63
uniprot id: G3QTF9
names: Similarity
messages: Belongs to the glutaredoxin family.

9595:LMBR1L
gene id: 9595:LMBR1L
uniprot id: G3RWF7
names: Similarity
messages: Belongs to the LIMR family.

9595:ATP5PF
gene id: 9595:ATP5PF
uniprot id: G3SFN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9595:PTPN12
gene id: 9595:PTPN12
uniprot id: G3SHJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

9595:LOC101148015
gene id: 9595:LOC101148015
uniprot id: G3RQ20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9595:MMP10
gene id: 9595:MMP10
uniprot id: G3RUD4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:ASIC5
gene id: 9595:ASIC5
uniprot id: G3SHE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9595:LOC101141279
gene id: 9595:LOC101141279
uniprot id: P30378
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
messages: Involved in the presentation of foreign antigens to the immune system.
messages: Membrane

9595:LOC101149308
gene id: 9595:LOC101149308
uniprot id: G3QI10
names: Subcellular Location Annotation
messages: Membrane

9595:SDR42E1
gene id: 9595:SDR42E1
uniprot id: G3RBJ8
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9595:LOC101141727
gene id: 9595:LOC101141727
uniprot id: A0A2I2Y424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9595:PCYT2
gene id: 9595:PCYT2
uniprot id: G3RDK2
names: Similarity
messages: Belongs to the cytidylyltransferase family.

9595:DUXB
gene id: 9595:DUXB
uniprot id: A0A2I2ZA34
names: Subcellular Location Annotation
messages: Nucleus

9595:PRDM12
gene id: 9595:PRDM12
uniprot id: G3S4A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

9595:MED7
gene id: 9595:MED7
uniprot id: G3QJD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9595:HOMER2
gene id: 9595:HOMER2
uniprot id: G3RI65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9595:TXLNA
gene id: 9595:TXLNA
uniprot id: G3QGT7
names: Similarity
messages: Belongs to the taxilin family.

9595:HOXB6
gene id: 9595:HOXB6
uniprot id: G3QJJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9595:LOC101144197
gene id: 9595:LOC101144197
uniprot id: G3QKY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9595:GLDN
gene id: 9595:GLDN
uniprot id: G3QLN5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:OPA3
gene id: 9595:OPA3
uniprot id: A0A2I2Z4S0
uniprot id: G3S0L1
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

9595:TLR2
gene id: 9595:TLR2
uniprot id: B3Y615
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
messages: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
messages: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).
messages: Membrane
messages: Membrane raft
messages: The ATG16L1-binding motif mediates interaction with ATG16L1.
messages: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
messages: phagosome membrane

9595:PKP1
gene id: 9595:PKP1
uniprot id: G3RPR6
names: Similarity
messages: Belongs to the beta-catenin family.

9595:NEU1
gene id: 9595:NEU1
uniprot id: G3R0S0
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9595:PTHLH
gene id: 9595:PTHLH
uniprot id: A0A2I2Z7L9
uniprot id: G3RRH1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9595:POMGNT1
gene id: 9595:POMGNT1
uniprot id: A0A2I2YUD3
uniprot id: A0A2I2ZHP4
uniprot id: G3QIV6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9595:MSTN
gene id: 9595:MSTN
uniprot id: A1C2V5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted
messages: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

9595:GATB
gene id: 9595:GATB
uniprot id: G3R678
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9595:CFAP300
gene id: 9595:CFAP300
uniprot id: G3QFA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9595:LOC101149484
gene id: 9595:LOC101149484
uniprot id: G3RGC9
names: Similarity
messages: Belongs to the cytochrome b5 family.

9595:MFSD4A
gene id: 9595:MFSD4A
uniprot id: A0A2I2YVS2
names: Subcellular Location Annotation
messages: Membrane

9595:MYSM1
gene id: 9595:MYSM1
uniprot id: G3QR94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.
messages: Nucleus

9595:MRPS7
gene id: 9595:MRPS7
uniprot id: G3QXD3
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9595:KDR
gene id: 9595:KDR
uniprot id: G3RAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:FBL
gene id: 9595:FBL
uniprot id: G3RZC3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9595:RPAP1
gene id: 9595:RPAP1
uniprot id: G3QVU2
names: Similarity
messages: Belongs to the RPAP1 family.

9595:SIX6
gene id: 9595:SIX6
uniprot id: G3RXM7
names: Subcellular Location Annotation
messages: Nucleus

9595:STEAP4
gene id: 9595:STEAP4
uniprot id: G3RBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9595:DLGAP3
gene id: 9595:DLGAP3
uniprot id: G3RC00
names: Similarity
messages: Belongs to the SAPAP family.

9595:TOMM40L
gene id: 9595:TOMM40L
uniprot id: A0A2I2Z5F0
uniprot id: G3QSG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:LOC101139480
gene id: 9595:LOC101139480
uniprot id: G3RW14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TRUB1
gene id: 9595:TRUB1
uniprot id: G3QPK0
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9595:RAG2
gene id: 9595:RAG2
uniprot id: G3SIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9595:ADRB3
gene id: 9595:ADRB3
uniprot id: G3S5Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
messages: Cell membrane
messages: Interacts with ARRDC3.
messages: Membrane

9595:RFX2
gene id: 9595:RFX2
uniprot id: A0A2I2YYL4
uniprot id: A0A2I2ZGI5
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101130985
gene id: 9595:LOC101130985
uniprot id: G3QXG0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:MED11
gene id: 9595:MED11
uniprot id: G3QRU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:TRPC5
gene id: 9595:TRPC5
uniprot id: G3RIJ6
names: Subcellular Location Annotation
messages: Membrane

9595:SYNGR1
gene id: 9595:SYNGR1
uniprot id: A0A2I2YTA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9595:ITGAX
gene id: 9595:ITGAX
uniprot id: G3RA67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:TBPL1
gene id: 9595:TBPL1
uniprot id: G3RU70
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9595:HDAC2
gene id: 9595:HDAC2
uniprot id: G3QRQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9595:LOC101139685
gene id: 9595:LOC101139685
uniprot id: G3QSR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9595:DOCK8
gene id: 9595:DOCK8
uniprot id: A0A2I2Z9P1
uniprot id: G3R0C4
names: Similarity
messages: Belongs to the DOCK family.

9595:RPS6KA3
gene id: 9595:RPS6KA3
uniprot id: G3R0F8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9595:ADAMDEC1
gene id: 9595:ADAMDEC1
uniprot id: G3QFW5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ERRFI1
gene id: 9595:ERRFI1
uniprot id: G3QU83
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9595:TM2D2
gene id: 9595:TM2D2
uniprot id: A0A2I2YX34
names: Subcellular Location Annotation
messages: Membrane

9595:PKIA
gene id: 9595:PKIA
uniprot id: G3RTH0
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9595:ATP6V1G2
gene id: 9595:ATP6V1G2
uniprot id: G3QT58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:ATP5PB
gene id: 9595:ATP5PB
uniprot id: G3QR73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9595:SDHB
gene id: 9595:SDHB
uniprot id: G3RJI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9595:GSTA4
gene id: 9595:GSTA4
uniprot id: G3QRL1
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9595:OPALIN
gene id: 9595:OPALIN
uniprot id: A0A2I2ZRR1
uniprot id: G3QF24
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9595:FCER1G
gene id: 9595:FCER1G
uniprot id: A0A2I2YN14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9595:ASB15
gene id: 9595:ASB15
uniprot id: G3QZR9
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:ZSCAN25
gene id: 9595:ZSCAN25
uniprot id: G3RLA2
names: Subcellular Location Annotation
messages: Nucleus

9595:CNNM4
gene id: 9595:CNNM4
uniprot id: G3R3R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9595:CTNNA2
gene id: 9595:CTNNA2
uniprot id: A0A2I2Y9A3
uniprot id: A0A2I2YNA1
uniprot id: G3RRY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9595:PDK2
gene id: 9595:PDK2
uniprot id: G3RHS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9595:MAN2B1
gene id: 9595:MAN2B1
uniprot id: G3RC23
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9595:NAT10
gene id: 9595:NAT10
uniprot id: G3RF58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9595:FGF1
gene id: 9595:FGF1
uniprot id: A0A2I2YI26
uniprot id: G3RPE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9595:ETV4
gene id: 9595:ETV4
uniprot id: G3QD39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:ITGA7
gene id: 9595:ITGA7
uniprot id: A0A2I2YSG4
uniprot id: A0A2I2Z3P5
uniprot id: A0A2I2ZTX6
uniprot id: G3QKX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:IL17C
gene id: 9595:IL17C
uniprot id: G3R9X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9595:LIAS
gene id: 9595:LIAS
uniprot id: A0A2I2YM44
uniprot id: G3SER2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

9595:PRR23A
gene id: 9595:PRR23A
uniprot id: G3QHM8
names: Similarity
messages: Belongs to the PRR23 family.

9595:EIF1
gene id: 9595:EIF1
uniprot id: G3SHY9
names: Similarity
messages: Belongs to the SUI1 family.

9595:MICAL1
gene id: 9595:MICAL1
uniprot id: A0A2I2ZFJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9595:STT3A
gene id: 9595:STT3A
uniprot id: G3R313
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9595:TRAK2
gene id: 9595:TRAK2
uniprot id: G3QKJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9595:UGT2B4
gene id: 9595:UGT2B4
uniprot id: G3RWI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9595:DCK
gene id: 9595:DCK
uniprot id: A0A2I2YPC2
names: Similarity
messages: Belongs to the DCK/DGK family.

9595:LOC109029219
gene id: 9595:LOC109029219
uniprot id: A0A2I2YF52
names: Similarity
messages: Belongs to the LCE family.

9595:NSUN2
gene id: 9595:NSUN2
uniprot id: A0A2I2YDN2
uniprot id: A0A2I2Z719
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9595:WDR82
gene id: 9595:WDR82
uniprot id: A0A2I2ZBG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9595:ABCD4
gene id: 9595:ABCD4
uniprot id: G3QJF4
names: Subcellular Location Annotation
messages: Membrane

9595:GRB2
gene id: 9595:GRB2
uniprot id: G3QTG9
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9595:LOC101152650
gene id: 9595:LOC101152650
uniprot id: G3S6G5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9595:TRPT1
gene id: 9595:TRPT1
uniprot id: G3S681
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

9595:SLC22A8
gene id: 9595:SLC22A8
uniprot id: G3RTH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane

9595:SLC9A1
gene id: 9595:SLC9A1
uniprot id: G3QGW0
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9595:TMEM168
gene id: 9595:TMEM168
uniprot id: G3RLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane
messages: Nucleus membrane

9595:LOC101153318
gene id: 9595:LOC101153318
uniprot id: G3R0D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:THAP10
gene id: 9595:THAP10
uniprot id: G3RDJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9595:PPDPFL
gene id: 9595:PPDPFL
uniprot id: G3QT11
names: Similarity
messages: Belongs to the PPDPF family.

9595:SLC1A4
gene id: 9595:SLC1A4
uniprot id: G3R6H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9595:AARSD1
gene id: 9595:AARSD1
uniprot id: G3SH26
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9595:MDFI
gene id: 9595:MDFI
uniprot id: G3QJP1
names: Similarity
messages: Belongs to the MDFI family.

9595:SMC4
gene id: 9595:SMC4
uniprot id: G3RD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Chromosome
messages: Nucleus

9595:RPL3L
gene id: 9595:RPL3L
uniprot id: G3R1R9
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9595:FLVCR1
gene id: 9595:FLVCR1
uniprot id: G3QH88
names: Subcellular Location Annotation
messages: Membrane

9595:RBP2
gene id: 9595:RBP2
uniprot id: G3R438
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:SLIT1
gene id: 9595:SLIT1
uniprot id: A0A2I2YCZ6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:CBX5
gene id: 9595:CBX5
uniprot id: G3QCU2
names: Subcellular Location Annotation
messages: Nucleus

9595:IL4I1
gene id: 9595:IL4I1
uniprot id: A0A2I2Z3B6
uniprot id: G3RPA7
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9595:C4A
gene id: 9595:C4A
uniprot id: A0A2I2YEP2
names: Subcellular Location Annotation
messages: Secreted

9595:ERMP1
gene id: 9595:ERMP1
uniprot id: G3QHK7
names: Subcellular Location Annotation
messages: Membrane

9595:SPTY2D1
gene id: 9595:SPTY2D1
uniprot id: G3R4C5
names: Similarity
messages: Belongs to the SPT2 family.

9595:SH3BGRL
gene id: 9595:SH3BGRL
uniprot id: G3SIZ4
names: Similarity
messages: Belongs to the SH3BGR family.

9595:XCR1
gene id: 9595:XCR1
uniprot id: G3S0Y6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:PFDN6
gene id: 9595:PFDN6
uniprot id: A0A2I2YD85
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9595:PGAP1
gene id: 9595:PGAP1
uniprot id: A0A2I2YM28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9595:PALM2AKAP2
gene id: 9595:PALM2AKAP2
uniprot id: A0A2I2ZUV6
names: Similarity
messages: Belongs to the paralemmin family.

9595:UBR2
gene id: 9595:UBR2
uniprot id: A0A2I2ZWA2
uniprot id: G3QNA5
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9595:MC2R
gene id: 9595:MC2R
uniprot id: G3QPS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

9595:FAM168B
gene id: 9595:FAM168B
uniprot id: G3QCX4
names: Similarity
messages: Belongs to the FAM168 family.

9595:LOC101151609
gene id: 9595:LOC101151609
uniprot id: A0A2I2ZBU0
names: Similarity
messages: Belongs to the LCE family.

9595:VPS26C
gene id: 9595:VPS26C
uniprot id: G3SB23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9595:DPPA5
gene id: 9595:DPPA5
uniprot id: G3R8J3
names: Similarity
messages: Belongs to the KHDC1 family.

9595:SMG5
gene id: 9595:SMG5
uniprot id: G3R5S7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

9595:LOC101141950
gene id: 9595:LOC101141950
uniprot id: G3S9H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TAC1
gene id: 9595:TAC1
uniprot id: A0A2I2YSA3
uniprot id: A0A2I2ZIT3
uniprot id: G3RDY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9595:EFTUD2
gene id: 9595:EFTUD2
uniprot id: G3RB35
names: Subcellular Location Annotation
messages: Nucleus

9595:KIF3C
gene id: 9595:KIF3C
uniprot id: G3QYI7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:SELE
gene id: 9595:SELE
uniprot id: G3QSS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:GDI2
gene id: 9595:GDI2
uniprot id: G3S4K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9595:IGF2R
gene id: 9595:IGF2R
uniprot id: G3QH23
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:EAF2
gene id: 9595:EAF2
uniprot id: G3SAD5
names: Similarity
messages: Belongs to the EAF family.

9595:YBEY
gene id: 9595:YBEY
uniprot id: A0A2I2YQQ5
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9595:LPCAT4
gene id: 9595:LPCAT4
uniprot id: G3QXF8
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9595:PLP2
gene id: 9595:PLP2
uniprot id: G3RTV4
names: Subcellular Location Annotation
messages: Membrane

9595:MRPL14
gene id: 9595:MRPL14
uniprot id: G3QTE8
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9595:ARG2
gene id: 9595:ARG2
uniprot id: G3QS73
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9595:MINDY3
gene id: 9595:MINDY3
uniprot id: G3R5Q3
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9595:ETV1
gene id: 9595:ETV1
uniprot id: A0A2I2Y8B8
uniprot id: A0A2I2Z0A8
uniprot id: A0A2I2ZVN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:FGB
gene id: 9595:FGB
uniprot id: G3RDU2
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9595:NDUFB8
gene id: 9595:NDUFB8
uniprot id: Q0MQE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:MOCS3
gene id: 9595:MOCS3
uniprot id: G3R0V0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

9595:CD28
gene id: 9595:CD28
uniprot id: A0A2I2Y8P2
names: Subcellular Location Annotation
messages: Membrane

9595:NMNAT1
gene id: 9595:NMNAT1
uniprot id: A0A2I2YBT2
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9595:NSRP1
gene id: 9595:NSRP1
uniprot id: G3RTX8
names: Similarity
messages: Belongs to the NSRP1 family.

9595:NPRL2
gene id: 9595:NPRL2
uniprot id: G3QW21
names: Similarity
messages: Belongs to the NPR2 family.

9595:CDC20B
gene id: 9595:CDC20B
uniprot id: A0A2I2ZT37
uniprot id: G3RQG4
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9595:TRAPPC1
gene id: 9595:TRAPPC1
uniprot id: G3QUA5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9595:CDH6
gene id: 9595:CDH6
uniprot id: G3RLA5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:PUF60
gene id: 9595:PUF60
uniprot id: A0A2I2Y9K9
uniprot id: A0A2I2ZC99
uniprot id: G3QPQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

9595:SLC7A10
gene id: 9595:SLC7A10
uniprot id: G3QTE3
names: Subcellular Location Annotation
messages: Membrane

9595:C3AR1
gene id: 9595:C3AR1
uniprot id: G3RG02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9595:ABCC10
gene id: 9595:ABCC10
uniprot id: A0A2I2YRY6
names: Subcellular Location Annotation
messages: Membrane

9595:RNF31
gene id: 9595:RNF31
uniprot id: G3RIX6
names: Similarity
messages: Belongs to the RBR family.

9595:CLUH
gene id: 9595:CLUH
uniprot id: G3RCB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

9595:ENAH
gene id: 9595:ENAH
uniprot id: A0A2I2Y910
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

9595:EYA2
gene id: 9595:EYA2
uniprot id: G3SKP8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9595:OLFML3
gene id: 9595:OLFML3
uniprot id: G3R9Q6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:POLR1C
gene id: 9595:POLR1C
uniprot id: G3R5P7
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9595:FMNL2
gene id: 9595:FMNL2
uniprot id: A0A2I2Z7A4
names: Similarity
messages: Belongs to the formin homology family.

9595:TMEM244
gene id: 9595:TMEM244
uniprot id: G3RXN8
names: Subcellular Location Annotation
messages: Membrane

9595:MS4A10
gene id: 9595:MS4A10
uniprot id: A0A2I2ZBN5
names: Similarity
messages: Belongs to the MS4A family.

9595:PELI3
gene id: 9595:PELI3
uniprot id: A0A2I2YYQ0
uniprot id: G3RBN9
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9595:SYS1
gene id: 9595:SYS1
uniprot id: G3QNG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9595:SLC6A9
gene id: 9595:SLC6A9
uniprot id: G3QM65
uniprot id: G3S6N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9595:ACOX3
gene id: 9595:ACOX3
uniprot id: G3RSD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9595:POLR2I
gene id: 9595:POLR2I
uniprot id: G3RHC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9595:IL1RAPL1
gene id: 9595:IL1RAPL1
uniprot id: G3QKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

9595:ELOVL1
gene id: 9595:ELOVL1
uniprot id: G3R4H1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9595:IZUMO3
gene id: 9595:IZUMO3
uniprot id: A0A2I2YUM5
uniprot id: G3R790
names: Similarity
messages: Belongs to the Izumo family.

9595:ATP6V0E1
gene id: 9595:ATP6V0E1
uniprot id: G3QUZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:MARVELD2
gene id: 9595:MARVELD2
uniprot id: A0A2I2Y6F8
uniprot id: G3RHQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9595:GNG12
gene id: 9595:GNG12
uniprot id: A0A2I2YIX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9595:RHD
gene id: 9595:RHD
uniprot id: Q28427
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
messages: Membrane

9595:PAQR5
gene id: 9595:PAQR5
uniprot id: G3QMZ6
uniprot id: G3S7G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:DZIP3
gene id: 9595:DZIP3
uniprot id: A0A2I2YK06
names: Subcellular Location Annotation
messages: Cytoplasm

9595:WNT3
gene id: 9595:WNT3
uniprot id: G3RQ89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:DGKZ
gene id: 9595:DGKZ
uniprot id: A0A2I2Y9C5
uniprot id: G3S053
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9595:SCRN2
gene id: 9595:SCRN2
uniprot id: G3QPG3
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9595:SGIP1
gene id: 9595:SGIP1
uniprot id: G3RU21
names: Function
names: Subcellular Location Annotation
messages: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
messages: clathrin-coated pit

9595:BEX2
gene id: 9595:BEX2
uniprot id: G3QS69
names: Similarity
messages: Belongs to the BEX family.

9595:INO80D
gene id: 9595:INO80D
uniprot id: G3RHR4
names: Subcellular Location Annotation
messages: Nucleus

9595:LUC7L2
gene id: 9595:LUC7L2
uniprot id: A0A2I2Z1F0
uniprot id: G3RKD8
names: Similarity
messages: Belongs to the Luc7 family.

9595:NKX3-1
gene id: 9595:NKX3-1
uniprot id: A0A2I2YFJ4
names: Subcellular Location Annotation
messages: Nucleus

9595:CDSN
gene id: 9595:CDSN
uniprot id: G3S1W3
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9595:OXA1L
gene id: 9595:OXA1L
uniprot id: G3SFA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9595:SERF2
gene id: 9595:SERF2
uniprot id: A0A2I2Y1V5
names: Similarity
messages: Belongs to the SERF family.

9595:CDC34
gene id: 9595:CDC34
uniprot id: G3QL57
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:UBA6
gene id: 9595:UBA6
uniprot id: G3RFM5
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9595:ITGB7
gene id: 9595:ITGB7
uniprot id: G3QV88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9595:RBM42
gene id: 9595:RBM42
uniprot id: A0A2I2YME1
uniprot id: G3RVH6
names: Similarity
messages: Belongs to the RRM RBM42 family.

9595:STATH
gene id: 9595:STATH
uniprot id: G3SG71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.
messages: Secreted

9595:EIF3I
gene id: 9595:EIF3I
uniprot id: G3QGU3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9595:SF3A3
gene id: 9595:SF3A3
uniprot id: A0A2I2YA81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

9595:BCL2
gene id: 9595:BCL2
uniprot id: G3QES9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

9595:LOC101146890
gene id: 9595:LOC101146890
uniprot id: A0A2I2Y4K8
uniprot id: A0A2I2Z8Q8
uniprot id: G3QRS3
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9595:KRT16
gene id: 9595:KRT16
uniprot id: G3RAL7
names: Similarity
messages: Belongs to the intermediate filament family.

9595:FTHL17
gene id: 9595:FTHL17
uniprot id: G3QY39
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9595:RPL23
gene id: 9595:RPL23
uniprot id: G3SHW8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.

9595:LOC101151628
gene id: 9595:LOC101151628
uniprot id: G3R2M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9595:PELI1
gene id: 9595:PELI1
uniprot id: G3RCA2
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9595:LDHD
gene id: 9595:LDHD
uniprot id: G3R505
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9595:ACP1
gene id: 9595:ACP1
uniprot id: G3RHR9
uniprot id: G3S306
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9595:RAB3GAP2
gene id: 9595:RAB3GAP2
uniprot id: G3RS87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

9595:EPCAM
gene id: 9595:EPCAM
uniprot id: G3SHA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
messages: Membrane
messages: tight junction

9595:CHD1L
gene id: 9595:CHD1L
uniprot id: G3QFI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9595:BCL9L
gene id: 9595:BCL9L
uniprot id: G3QYM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9595:STAT2
gene id: 9595:STAT2
uniprot id: G3RWV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9595:SLC6A12
gene id: 9595:SLC6A12
uniprot id: G3QX15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Lateral cell membrane
messages: Membrane

9595:TBC1D7
gene id: 9595:TBC1D7
uniprot id: A0A2I2YE76
uniprot id: G3QML5
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9595:KCNS3
gene id: 9595:KCNS3
uniprot id: G3QF91
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:CENPE
gene id: 9595:CENPE
uniprot id: A0A2I2ZT31
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:PIGK
gene id: 9595:PIGK
uniprot id: G3R1G4
names: Similarity
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.

9595:DUOX1
gene id: 9595:DUOX1
uniprot id: G3R9G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

9595:DLGAP4
gene id: 9595:DLGAP4
uniprot id: A0A2I2ZBH1
uniprot id: G3QRS7
uniprot id: G3QXA3
names: Similarity
messages: Belongs to the SAPAP family.

9595:ZNF397
gene id: 9595:ZNF397
uniprot id: G3RPS0
names: Subcellular Location Annotation
messages: Nucleus

9595:MTNR1A
gene id: 9595:MTNR1A
uniprot id: G3R7Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9595:MYBL2
gene id: 9595:MYBL2
uniprot id: G3RMI6
names: Subcellular Location Annotation
messages: Nucleus

9595:PIGV
gene id: 9595:PIGV
uniprot id: G3QQK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9595:MFSD11
gene id: 9595:MFSD11
uniprot id: G3RRG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9595:PICALM
gene id: 9595:PICALM
uniprot id: A0A2I2ZKV2
uniprot id: G3SCQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9595:ARL6
gene id: 9595:ARL6
uniprot id: A0A2I2Z0Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9595:CNTN2
gene id: 9595:CNTN2
uniprot id: G3RFQ6
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9595:LOC101128409
gene id: 9595:LOC101128409
uniprot id: G3R0G2
names: Similarity
messages: Belongs to the NXPE family.

9595:ZC3H12D
gene id: 9595:ZC3H12D
uniprot id: G3QRX9
names: Similarity
messages: Belongs to the ZC3H12 family.

9595:ATP8B1
gene id: 9595:ATP8B1
uniprot id: G3RCJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9595:DPF3
gene id: 9595:DPF3
uniprot id: G3S544
names: Similarity
messages: Belongs to the requiem/DPF family.

9595:GSTK1
gene id: 9595:GSTK1
uniprot id: A0A2I2Y8N2
uniprot id: G3R8V8
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9595:LOC101148386
gene id: 9595:LOC101148386
uniprot id: G3QYN6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9595:GADD45G
gene id: 9595:GADD45G
uniprot id: G3QQR8
names: Similarity
messages: Belongs to the GADD45 family.

9595:MAN2C1
gene id: 9595:MAN2C1
uniprot id: A0A2I2ZC02
uniprot id: G3RFT8
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

9595:RGS5
gene id: 9595:RGS5
uniprot id: A0A2I2YCX4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9595:E2F4
gene id: 9595:E2F4
uniprot id: G3S5T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:VAMP2
gene id: 9595:VAMP2
uniprot id: A0A2I2Z1E0
uniprot id: G3QSL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9595:DOK4
gene id: 9595:DOK4
uniprot id: A0A2I2ZYZ4
uniprot id: G3R9P0
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9595:MCM8
gene id: 9595:MCM8
uniprot id: G3S967
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9595:TMCO1
gene id: 9595:TMCO1
uniprot id: A0A2I2ZQ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:TENT5C
gene id: 9595:TENT5C
uniprot id: A0A2I2YLA0
names: Similarity
messages: Belongs to the TENT family.

9595:SGCG
gene id: 9595:SGCG
uniprot id: G3REE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9595:TAP1
gene id: 9595:TAP1
uniprot id: G3R5U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

9595:METTL6
gene id: 9595:METTL6
uniprot id: A0A2I2Z1U9
uniprot id: G3RS32
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9595:IDO1
gene id: 9595:IDO1
uniprot id: G3SJC1
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9595:PHLDA3
gene id: 9595:PHLDA3
uniprot id: A0A2I2ZJ10
names: Subcellular Location Annotation
messages: Cytoplasm

9595:LDAF1
gene id: 9595:LDAF1
uniprot id: G3R0N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9595:NAE1
gene id: 9595:NAE1
uniprot id: A0A2I2YN42
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

9595:NAA38
gene id: 9595:NAA38
uniprot id: A0A2I2YTV6
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

9595:BZW1
gene id: 9595:BZW1
uniprot id: G3SA22
names: Similarity
messages: Belongs to the BZW family.

9595:CXCL14
gene id: 9595:CXCL14
uniprot id: G3QK30
names: Subcellular Location Annotation
messages: Secreted

9595:NEK6
gene id: 9595:NEK6
uniprot id: G3R8Y7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:FLAD1
gene id: 9595:FLAD1
uniprot id: G3RV92
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9595:ACYP2
gene id: 9595:ACYP2
uniprot id: G3R691
names: Similarity
messages: Belongs to the acylphosphatase family.

9595:CRX
gene id: 9595:CRX
uniprot id: G3RYT0
names: Subcellular Location Annotation
messages: Nucleus

9595:CSF1R
gene id: 9595:CSF1R
uniprot id: G3RMC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:SMUG1
gene id: 9595:SMUG1
uniprot id: G3QCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9595:MED21
gene id: 9595:MED21
uniprot id: G3RJL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9595:CD2
gene id: 9595:CD2
uniprot id: G3QRA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:GLS2
gene id: 9595:GLS2
uniprot id: G3RKB6
names: Similarity
messages: Belongs to the glutaminase family.

9595:EIF3D
gene id: 9595:EIF3D
uniprot id: G3RM58
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9595:MBOAT4
gene id: 9595:MBOAT4
uniprot id: G3QLI0
names: Subcellular Location Annotation
messages: Membrane

9595:LNPEP
gene id: 9595:LNPEP
uniprot id: A0A2I2ZXA2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9595:PSEN2
gene id: 9595:PSEN2
uniprot id: G3SCU1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

9595:LOC101142817
gene id: 9595:LOC101142817
uniprot id: G3SC01
names: Similarity
messages: Belongs to the pro/parathymosin family.

9595:BHMT2
gene id: 9595:BHMT2
uniprot id: G3QL14
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9595:MRPL22
gene id: 9595:MRPL22
uniprot id: A0A2I2Y3V1
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9595:PMP2
gene id: 9595:PMP2
uniprot id: G3RTZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9595:ZDHHC22
gene id: 9595:ZDHHC22
uniprot id: G3R3R5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:MIEF2
gene id: 9595:MIEF2
uniprot id: G3SF57
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9595:CMBL
gene id: 9595:CMBL
uniprot id: G3RE16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9595:PATZ1
gene id: 9595:PATZ1
uniprot id: A0A2I2Y7W2
uniprot id: A0A2I2ZTQ2
uniprot id: G3RLU7
names: Subcellular Location Annotation
messages: Nucleus

9595:CATSPERE
gene id: 9595:CATSPERE
uniprot id: G3QSJ2
names: Similarity
messages: Belongs to the CATSPERD family.

9595:LOC101138570
gene id: 9595:LOC101138570
uniprot id: G3R0Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

9595:LOC101149517
gene id: 9595:LOC101149517
uniprot id: A0A2I2Z5Y2
uniprot id: G3R4P4
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9595:GPR137C
gene id: 9595:GPR137C
uniprot id: G3RE89
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9595:ATP6V1C1
gene id: 9595:ATP6V1C1
uniprot id: G3QNF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9595:CRYZ
gene id: 9595:CRYZ
uniprot id: A0A2I2Y795
uniprot id: A0A2I2YE25
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9595:PDE1B
gene id: 9595:PDE1B
uniprot id: A0A2I2ZYH9
uniprot id: G3QZ83
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:RPS6KB2
gene id: 9595:RPS6KB2
uniprot id: G3R3D8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9595:DONSON
gene id: 9595:DONSON
uniprot id: G3R9E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

9595:C2BH2orf76
gene id: 9595:C2BH2orf76
uniprot id: G3QEX3
names: Similarity
messages: Belongs to the UPF0538 family.

9595:LOC101151967
gene id: 9595:LOC101151967
uniprot id: G3RNK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:OTUD7B
gene id: 9595:OTUD7B
uniprot id: G3SI66
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:ZFHX2
gene id: 9595:ZFHX2
uniprot id: G3QQN8
names: Subcellular Location Annotation
messages: Nucleus

9595:FBXO32
gene id: 9595:FBXO32
uniprot id: G3QKF2
names: Subcellular Location Annotation
messages: Nucleus

9595:IZUMO1
gene id: 9595:IZUMO1
uniprot id: G3QFY5
names: Similarity
messages: Belongs to the Izumo family.

9595:AMBP
gene id: 9595:AMBP
uniprot id: G3RE67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9595:STX5
gene id: 9595:STX5
uniprot id: G3QHQ6
names: Similarity
messages: Belongs to the syntaxin family.

9595:FAM76A
gene id: 9595:FAM76A
uniprot id: A0A2I2ZL12
uniprot id: A0A2I2ZME3
names: Similarity
messages: Belongs to the FAM76 family.

9595:ARL6IP4
gene id: 9595:ARL6IP4
uniprot id: A0A2I2YSV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: Nucleus speckle
messages: nucleolus

9595:KCNA6
gene id: 9595:KCNA6
uniprot id: A0A2I2YQ40
names: Subcellular Location Annotation
messages: Membrane

9595:YIF1A
gene id: 9595:YIF1A
uniprot id: G3R2S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9595:ATG101
gene id: 9595:ATG101
uniprot id: G3QU82
names: Similarity
messages: Belongs to the ATG101 family.

9595:NID1
gene id: 9595:NID1
uniprot id: G3SAI9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9595:TSFM
gene id: 9595:TSFM
uniprot id: G3QGE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

9595:SLC22A4
gene id: 9595:SLC22A4
uniprot id: G3R4H4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Interacts with PDZK1.

9595:NIT1
gene id: 9595:NIT1
uniprot id: A0A2I2Z833
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9595:LASP1
gene id: 9595:LASP1
uniprot id: A0A2I2YNI2
uniprot id: A0A2I2YUK1
uniprot id: G3QLF9
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9595:VPS29
gene id: 9595:VPS29
uniprot id: A0A2I2YR60
uniprot id: G3QU67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9595:CSTF1
gene id: 9595:CSTF1
uniprot id: G3QW97
names: Subcellular Location Annotation
messages: Nucleus

9595:TRAPPC6B
gene id: 9595:TRAPPC6B
uniprot id: G3QCW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9595:LOC101147097
gene id: 9595:LOC101147097
uniprot id: G3QKQ7
names: Similarity
messages: Belongs to the HPF1 family.

9595:POLA2
gene id: 9595:POLA2
uniprot id: G3QKN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

9595:MAPRE3
gene id: 9595:MAPRE3
uniprot id: A0A2I2Z4P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9595:TTYH2
gene id: 9595:TTYH2
uniprot id: G3QET3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9595:MEF2A
gene id: 9595:MEF2A
uniprot id: A0A2I2YYW0
uniprot id: A0A2I2Z9B1
uniprot id: G3SD93
names: Subcellular Location Annotation
messages: Nucleus

9595:TTYH3
gene id: 9595:TTYH3
uniprot id: G3QM48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9595:PAQR7
gene id: 9595:PAQR7
uniprot id: A0A2I2YCV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:RIPPLY3
gene id: 9595:RIPPLY3
uniprot id: A0A2I2YU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9595:AGBL1
gene id: 9595:AGBL1
uniprot id: G3SKW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9595:IL3
gene id: 9595:IL3
uniprot id: G3QFG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-3 family.
messages: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
messages: Secreted

9595:FRZB
gene id: 9595:FRZB
uniprot id: G3QSJ7
names: Caution
names: Function
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9595:ARSJ
gene id: 9595:ARSJ
uniprot id: G3RAC0
names: Similarity
messages: Belongs to the sulfatase family.

9595:MRPL20
gene id: 9595:MRPL20
uniprot id: G3RU51
uniprot id: G3SDQ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9595:PIGH
gene id: 9595:PIGH
uniprot id: G3QGM9
names: Similarity
messages: Belongs to the PIGH family.

9595:SPTBN2
gene id: 9595:SPTBN2
uniprot id: G3R7Q6
names: Similarity
messages: Belongs to the spectrin family.

9595:GAL3ST3
gene id: 9595:GAL3ST3
uniprot id: G3RUM1
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9595:NUF2
gene id: 9595:NUF2
uniprot id: G3QY78
names: Similarity
messages: Belongs to the NUF2 family.

9595:BORA
gene id: 9595:BORA
uniprot id: G3QP94
names: Similarity
messages: Belongs to the BORA family.

9595:TMEM225B
gene id: 9595:TMEM225B
uniprot id: A0A2I2ZHR8
names: Subcellular Location Annotation
messages: Membrane

9595:BPGM
gene id: 9595:BPGM
uniprot id: G3QX34
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9595:GRIA3
gene id: 9595:GRIA3
uniprot id: G3R2A6
uniprot id: G3SEM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9595:LDB1
gene id: 9595:LDB1
uniprot id: G3QIB3
names: Similarity
messages: Belongs to the LDB family.

9595:RPL10A
gene id: 9595:RPL10A
uniprot id: G3RV13
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9595:POLR2G
gene id: 9595:POLR2G
uniprot id: G3R7V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9595:LOC101128980
gene id: 9595:LOC101128980
uniprot id: G3RSJ4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:INSL6
gene id: 9595:INSL6
uniprot id: G3R094
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: May have a role in sperm development and fertilization.
messages: Secreted

9595:IDH3A
gene id: 9595:IDH3A
uniprot id: G3QII7
uniprot id: G3SDQ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9595:PORCN
gene id: 9595:PORCN
uniprot id: A0A2I2Y799
uniprot id: A0A2I2YZS7
names: Subcellular Location Annotation
messages: Membrane

9595:SEH1L
gene id: 9595:SEH1L
uniprot id: G3R6H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9595:EXOC7
gene id: 9595:EXOC7
uniprot id: A0A2I2YQS2
uniprot id: A0A2I2ZTN5
uniprot id: G3RUS4
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9595:C8H8orf33
gene id: 9595:C8H8orf33
uniprot id: G3RKS6
names: Similarity
messages: Belongs to the UPF0488 family.

9595:CERCAM
gene id: 9595:CERCAM
uniprot id: G3QQP6
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9595:PRAF2
gene id: 9595:PRAF2
uniprot id: G3QE86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9595:ADGRA3
gene id: 9595:ADGRA3
uniprot id: G3SEX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9595:ATP23
gene id: 9595:ATP23
uniprot id: G3R572
names: Similarity
messages: Belongs to the peptidase M76 family.

9595:STAT1
gene id: 9595:STAT1
uniprot id: A0A2I2YUU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9595:LOC109023038
gene id: 9595:LOC109023038
uniprot id: G3RWW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

9595:MAP7D2
gene id: 9595:MAP7D2
uniprot id: A0A2I2YYQ9
uniprot id: G3QXP4
names: Similarity
messages: Belongs to the MAP7 family.

9595:FOXN3
gene id: 9595:FOXN3
uniprot id: A0A2I2Y453
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
messages: Nucleus

9595:POLR3H
gene id: 9595:POLR3H
uniprot id: A0A2I2ZTU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9595:LRRFIP2
gene id: 9595:LRRFIP2
uniprot id: A0A2I2YZD3
uniprot id: G3QHD2
names: Similarity
messages: Belongs to the LRRFIP family.

9595:LOC101153190
gene id: 9595:LOC101153190
uniprot id: G3RGS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.
messages: Nucleus
messages: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening.

9595:SEC61G
gene id: 9595:SEC61G
uniprot id: G3QSU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:SLC12A9
gene id: 9595:SLC12A9
uniprot id: G3QGM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9595:RAMP2
gene id: 9595:RAMP2
uniprot id: G3QLL9
names: Similarity
messages: Belongs to the RAMP family.

9595:ARR3
gene id: 9595:ARR3
uniprot id: G3QUR5
names: Similarity
messages: Belongs to the arrestin family.

9595:TGFA
gene id: 9595:TGFA
uniprot id: A0A2I2ZBF2
uniprot id: A0A2I2ZCX9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ACSS1
gene id: 9595:ACSS1
uniprot id: A0A2I2YQX6
uniprot id: G3QG16
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:IRF6
gene id: 9595:IRF6
uniprot id: A0A2I2YEL4
names: Subcellular Location Annotation
messages: Nucleus

9595:PON1
gene id: 9595:PON1
uniprot id: G3QPZ3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9595:THEMIS2
gene id: 9595:THEMIS2
uniprot id: G3R1E7
names: Similarity
messages: Belongs to the themis family.

9595:FSCN3
gene id: 9595:FSCN3
uniprot id: G3RKS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9595:DLL1
gene id: 9595:DLL1
uniprot id: G3QRX5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9595:PEAR1
gene id: 9595:PEAR1
uniprot id: G3RDA5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:IFNB1
gene id: 9595:IFNB1
uniprot id: G3RM24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9595:VAPA
gene id: 9595:VAPA
uniprot id: G3QH36
uniprot id: G3SJ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:TUFM
gene id: 9595:TUFM
uniprot id: A0A2I2YVU5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9595:ZC2HC1C
gene id: 9595:ZC2HC1C
uniprot id: G3SBR6
names: Similarity
messages: Belongs to the ZC2HC1 family.

9595:ASPHD1
gene id: 9595:ASPHD1
uniprot id: G3RHW5
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9595:PNPLA4
gene id: 9595:PNPLA4
uniprot id: G3QRQ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PAPOLA
gene id: 9595:PAPOLA
uniprot id: G3QTX2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

9595:MRPL11
gene id: 9595:MRPL11
uniprot id: G3QG30
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9595:POU4F2
gene id: 9595:POU4F2
uniprot id: G3QHI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9595:DCST2
gene id: 9595:DCST2
uniprot id: G3RDB7
names: Subcellular Location Annotation
messages: Membrane

9595:IL5RA
gene id: 9595:IL5RA
uniprot id: A0A2I2ZZ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.
messages: Membrane

9595:PDE1A
gene id: 9595:PDE1A
uniprot id: A0A2I2YVR3
uniprot id: A0A2I2ZTQ4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:ACTG1
gene id: 9595:ACTG1
uniprot id: G3RDT6
names: Similarity
messages: Belongs to the actin family.

9595:RBPJ
gene id: 9595:RBPJ
uniprot id: A0A2I2Z7A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9595:THUMPD3
gene id: 9595:THUMPD3
uniprot id: G3QEA2
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9595:TRIM21
gene id: 9595:TRIM21
uniprot id: G3QUH3
names: Subcellular Location Annotation
messages: Cytoplasm

9595:NTF4
gene id: 9595:NTF4
uniprot id: G3QRG5
names: Similarity
messages: Belongs to the NGF-beta family.

9595:MFSD14B
gene id: 9595:MFSD14B
uniprot id: G3QZH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9595:EPB41
gene id: 9595:EPB41
uniprot id: A0A2I2Y6N1
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex
messages: cytoskeleton

9595:CD52
gene id: 9595:CD52
uniprot id: G3QXI4
names: Function
names: Subcellular Location Annotation
messages: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
messages: Membrane

9595:PIK3C2B
gene id: 9595:PIK3C2B
uniprot id: G3QG89
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9595:FPGS
gene id: 9595:FPGS
uniprot id: G3QF64
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

9595:TRH
gene id: 9595:TRH
uniprot id: A0A2I2YDN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9595:SRP9
gene id: 9595:SRP9
uniprot id: G3R7D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9595:PRIMPOL
gene id: 9595:PRIMPOL
uniprot id: G3R887
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9595:ECHDC2
gene id: 9595:ECHDC2
uniprot id: A0A2I2Z3F8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9595:GGACT
gene id: 9595:GGACT
uniprot id: A0A2I2Z8I1
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9595:PPIB
gene id: 9595:PPIB
uniprot id: G3R669
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9595:GFUS
gene id: 9595:GFUS
uniprot id: G3QIY4
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9595:IZUMO1R
gene id: 9595:IZUMO1R
uniprot id: G3RFV1
names: Similarity
messages: Belongs to the folate receptor family.

9595:CCR8
gene id: 9595:CCR8
uniprot id: G3QTG2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:DPY30
gene id: 9595:DPY30
uniprot id: A0A2I2YG65
names: Similarity
messages: Belongs to the dpy-30 family.

9595:COG7
gene id: 9595:COG7
uniprot id: G3QGR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:UBE2I
gene id: 9595:UBE2I
uniprot id: A0A2I2YHE1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:PRKN
gene id: 9595:PRKN
uniprot id: A0A2I2YTU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. Parkin subfamily.
messages: Forms an E3 ubiquitin ligase complex.
messages: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
messages: Mitochondrion
messages: cytosol

9595:JPH1
gene id: 9595:JPH1
uniprot id: G3QK17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9595:LOC101136992
gene id: 9595:LOC101136992
uniprot id: A0A2I2YS64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative pheromone receptor.

9595:ADI1
gene id: 9595:ADI1
uniprot id: G3SKI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

9595:LAP3
gene id: 9595:LAP3
uniprot id: G3QFL8
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9595:HIKESHI
gene id: 9595:HIKESHI
uniprot id: G3SJD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9595:PTPRG
gene id: 9595:PTPRG
uniprot id: G3QVF1
uniprot id: G3SI67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9595:DNAAF4
gene id: 9595:DNAAF4
uniprot id: A0A2I2ZXF6
uniprot id: G3QRQ2
uniprot id: Q863A5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Interacts with ZMYND10 (By similarity). Interacts with STUB1 (By similarity). Interacts with ESR1 and ESR2. Interacts with DNAAF2 (By similarity). Interacts with CCT3, CCT4, CCT5 and CCT8 (By similarity). Interacts with DNAAF6/PIH1D3 (By similarity).
messages: Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility (By similarity).
messages: Nucleus
messages: neuron projection

9595:SMG7
gene id: 9595:SMG7
uniprot id: G3RYM6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

9595:GSG1L2
gene id: 9595:GSG1L2
uniprot id: G3QZL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9595:TRAPPC3
gene id: 9595:TRAPPC3
uniprot id: G3QPZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9595:CD1B
gene id: 9595:CD1B
uniprot id: G3QRI4
names: Similarity
messages: Belongs to the MHC class I family.

9595:RP2
gene id: 9595:RP2
uniprot id: G3QUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9595:LOC101149550
gene id: 9595:LOC101149550
uniprot id: G3QX78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:NLRP8
gene id: 9595:NLRP8
uniprot id: G3QK83
names: Similarity
messages: Belongs to the NLRP family.

9595:C11H11orf68
gene id: 9595:C11H11orf68
uniprot id: G3QQ36
names: Similarity
messages: Belongs to the UPF0696 family.

9595:CROT
gene id: 9595:CROT
uniprot id: G3RST5
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9595:GALNT5
gene id: 9595:GALNT5
uniprot id: G3QJ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:PEX1
gene id: 9595:PEX1
uniprot id: G3QQV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: cytosol

9595:WASF3
gene id: 9595:WASF3
uniprot id: A0A2I2ZQA9
uniprot id: G3R9W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9595:ACTR3
gene id: 9595:ACTR3
uniprot id: G3SCF3
names: Similarity
messages: Belongs to the actin family.

9595:TRPV4
gene id: 9595:TRPV4
uniprot id: G3QPN3
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101134802
gene id: 9595:LOC101134802
uniprot id: G3RJC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:CHRNB4
gene id: 9595:CHRNB4
uniprot id: G3R4J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:CP
gene id: 9595:CP
uniprot id: G3RY85
names: Similarity
messages: Belongs to the multicopper oxidase family.

9595:LPIN1
gene id: 9595:LPIN1
uniprot id: G3QSY1
names: Similarity
messages: Belongs to the lipin family.

9595:STX10
gene id: 9595:STX10
uniprot id: G3R225
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9595:SYCE1
gene id: 9595:SYCE1
uniprot id: G3QLD7
names: Similarity
messages: Belongs to the SYCE family.

9595:NUTM1
gene id: 9595:NUTM1
uniprot id: G3QXF0
uniprot id: G3RUC8
names: Similarity
messages: Belongs to the NUT family.

9595:ADAM22
gene id: 9595:ADAM22
uniprot id: A0A2I2YXV8
uniprot id: G3QI27
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:TNKS2
gene id: 9595:TNKS2
uniprot id: G3R2V0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:CCDC149
gene id: 9595:CCDC149
uniprot id: A0A2I2ZYS2
uniprot id: G3R3U2
names: Similarity
messages: Belongs to the CCDC149 family.

9595:SFXN1
gene id: 9595:SFXN1
uniprot id: G3QYR9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9595:LOC101136583
gene id: 9595:LOC101136583
uniprot id: G3RBT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9595:SYNDIG1L
gene id: 9595:SYNDIG1L
uniprot id: G3R0A6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:SRRT
gene id: 9595:SRRT
uniprot id: G3QGN2
names: Similarity
messages: Belongs to the ARS2 family.

9595:FAM83C
gene id: 9595:FAM83C
uniprot id: G3R8T6
names: Similarity
messages: Belongs to the FAM83 family.

9595:SENP3
gene id: 9595:SENP3
uniprot id: G3R7B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9595:NDUFS2
gene id: 9595:NDUFS2
uniprot id: Q0MQG4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme. Interacts with NDUFAF3. Interacts with NDUFAF7 (By similarity). Interacts with CERS2 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (By similarity). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity).
messages: Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to stabilize the early intermediate complex.
messages: Mitochondrion inner membrane

9595:FUT11
gene id: 9595:FUT11
uniprot id: G3QTL7
uniprot id: G3RPS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9595:LOC101128005
gene id: 9595:LOC101128005
uniprot id: G3RHE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:LXN
gene id: 9595:LXN
uniprot id: G3QKQ9
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9595:RIDA
gene id: 9595:RIDA
uniprot id: G3QFT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9595:DNAAF1
gene id: 9595:DNAAF1
uniprot id: G3RM43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF1 family.
messages: Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.
messages: cilium

9595:SPO11
gene id: 9595:SPO11
uniprot id: A0A2I2YML3
uniprot id: G3R0G7
names: Similarity
messages: Belongs to the TOP6A family.

9595:GRPR
gene id: 9595:GRPR
uniprot id: G3RL33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TRAF6
gene id: 9595:TRAF6
uniprot id: G3QST5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9595:ANKRD34A
gene id: 9595:ANKRD34A
uniprot id: A0A2I2YNF1
names: Similarity
messages: Belongs to the ANKRD34 family.

9595:LPAR3
gene id: 9595:LPAR3
uniprot id: G3R648
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SPATA18
gene id: 9595:SPATA18
uniprot id: A0A2I2ZD49
uniprot id: G3QZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9595:LOC101130686
gene id: 9595:LOC101130686
uniprot id: G3RWS7
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9595:ATP6V0D1
gene id: 9595:ATP6V0D1
uniprot id: G3RB21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:HNF1B
gene id: 9595:HNF1B
uniprot id: A0A2I2Z4H1
uniprot id: G3S805
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9595:MTCP1
gene id: 9595:MTCP1
uniprot id: A0A2I2ZHP0
names: Similarity
messages: Belongs to the TCL1 family.

9595:LOC101152596
gene id: 9595:LOC101152596
uniprot id: G3REX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:TBC1D31
gene id: 9595:TBC1D31
uniprot id: G3R1F4
uniprot id: G3S530
names: Function
names: Subcellular Location Annotation
messages: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
messages: centriolar satellite
messages: cilium basal body

9595:TMEM233
gene id: 9595:TMEM233
uniprot id: G3RZD9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:GADL1
gene id: 9595:GADL1
uniprot id: G3QCW3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9595:CENPQ
gene id: 9595:CENPQ
uniprot id: G3RW50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9595:LRRFIP1
gene id: 9595:LRRFIP1
uniprot id: G3QZC0
names: Similarity
messages: Belongs to the LRRFIP family.

9595:CDIP1
gene id: 9595:CDIP1
uniprot id: G3S7S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9595:ELOA
gene id: 9595:ELOA
uniprot id: G3RGB1
names: Subcellular Location Annotation
messages: Nucleus

9595:NARF
gene id: 9595:NARF
uniprot id: A0A2I2ZGA6
names: Similarity
messages: Belongs to the NARF family.

9595:TMEM88
gene id: 9595:TMEM88
uniprot id: G3RH25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9595:SUDS3
gene id: 9595:SUDS3
uniprot id: G3R5Z9
names: Subcellular Location Annotation
messages: Nucleus

9595:CSMD3
gene id: 9595:CSMD3
uniprot id: A0A2I2ZUL6
uniprot id: G3QU22
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:FAM20A
gene id: 9595:FAM20A
uniprot id: G3QKR8
names: Similarity
messages: Belongs to the FAM20 family.

9595:ARHGAP26
gene id: 9595:ARHGAP26
uniprot id: G3QVT9
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9595:NDUFS6
gene id: 9595:NDUFS6
uniprot id: Q0MQH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9595:PSMB5
gene id: 9595:PSMB5
uniprot id: G3S725
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:LOC101138998
gene id: 9595:LOC101138998
uniprot id: G3RRI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

9595:LOC101124683
gene id: 9595:LOC101124683
uniprot id: A0A2I2ZKV1
uniprot id: A0A2I2ZNA6
uniprot id: G3S5X7
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9595:PRKRA
gene id: 9595:PRKRA
uniprot id: G3QSJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRKRA family.
messages: perinuclear region

9595:GPSM2
gene id: 9595:GPSM2
uniprot id: G3QPV4
names: Similarity
messages: Belongs to the GPSM family.

9595:LOC101132985
gene id: 9595:LOC101132985
uniprot id: A0A2I2ZDI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MTR
gene id: 9595:MTR
uniprot id: G3RTZ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

9595:STARD3
gene id: 9595:STARD3
uniprot id: G3QW10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:CFC1B
gene id: 9595:CFC1B
uniprot id: G3SED3
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ALDH18A1
gene id: 9595:ALDH18A1
uniprot id: G3R9U3
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9595:TMEM176A
gene id: 9595:TMEM176A
uniprot id: A0A2I2ZV82
names: Similarity
messages: Belongs to the TMEM176 family.

9595:LYRM9
gene id: 9595:LYRM9
uniprot id: A0A2I2YAL9
uniprot id: G3QS33
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

9595:ATG3
gene id: 9595:ATG3
uniprot id: G3QUT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG3 family.
messages: Cytoplasm

9595:LIM2
gene id: 9595:LIM2
uniprot id: G3RFP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

9595:ZMPSTE24
gene id: 9595:ZMPSTE24
uniprot id: G3SDX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9595:MRPL30
gene id: 9595:MRPL30
uniprot id: A0A2I2YL41
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9595:ALDH3A1
gene id: 9595:ALDH3A1
uniprot id: G3S7E9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:FMO5
gene id: 9595:FMO5
uniprot id: G3S9Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9595:SIRT4
gene id: 9595:SIRT4
uniprot id: G3SBZ3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

9595:INHBA
gene id: 9595:INHBA
uniprot id: A0A2I2ZMR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9595:MTCH2
gene id: 9595:MTCH2
uniprot id: A0A2I2YWI5
uniprot id: G3QYZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:SOX14
gene id: 9595:SOX14
uniprot id: G3RDD2
names: Subcellular Location Annotation
messages: Nucleus

9595:SNW1
gene id: 9595:SNW1
uniprot id: G3S3X9
uniprot id: G3SJU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9595:RNF182
gene id: 9595:RNF182
uniprot id: A0A2I2Y7J3
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9595:MARK2
gene id: 9595:MARK2
uniprot id: A0A2I2Y6Q3
uniprot id: A0A2I2ZW92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9595:MAOB
gene id: 9595:MAOB
uniprot id: G3QD91
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9595:KIF2B
gene id: 9595:KIF2B
uniprot id: G3QVK2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:TASOR
gene id: 9595:TASOR
uniprot id: A0A2I2YW35
uniprot id: G3R6V4
names: Similarity
messages: Belongs to the TASOR family.

9595:ADK
gene id: 9595:ADK
uniprot id: A0A2I2YPI6
uniprot id: G3QRM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9595:NDUFB5
gene id: 9595:NDUFB5
uniprot id: A0A2I2YPV4
uniprot id: A0A2I2ZAF4
uniprot id: Q0MQD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:CHST2
gene id: 9595:CHST2
uniprot id: G3R5W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9595:INTS14
gene id: 9595:INTS14
uniprot id: A0A2I2YSE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9595:FOXJ3
gene id: 9595:FOXJ3
uniprot id: A0A2I2YRH3
names: Subcellular Location Annotation
messages: Nucleus

9595:EIF3F
gene id: 9595:EIF3F
uniprot id: G3SER3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9595:ITM2A
gene id: 9595:ITM2A
uniprot id: G3RPS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9595:CWC15
gene id: 9595:CWC15
uniprot id: G3R8D2
names: Similarity
messages: Belongs to the CWC15 family.

9595:LOC101151025
gene id: 9595:LOC101151025
uniprot id: G3SG11
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9595:LAMA4
gene id: 9595:LAMA4
uniprot id: G3RGA8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9595:HDAC3
gene id: 9595:HDAC3
uniprot id: G3RJT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9595:GALR2
gene id: 9595:GALR2
uniprot id: G3R0C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:GSS
gene id: 9595:GSS
uniprot id: G3QVM8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9595:CACNB2
gene id: 9595:CACNB2
uniprot id: G3SGK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

9595:TNFSF13
gene id: 9595:TNFSF13
uniprot id: G3R7B3
uniprot id: G3S155
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9595:GIMAP8
gene id: 9595:GIMAP8
uniprot id: G3S4T9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9595:CLN8
gene id: 9595:CLN8
uniprot id: A0A2I2YDC0
names: Subcellular Location Annotation
messages: Membrane

9595:IL4R
gene id: 9595:IL4R
uniprot id: G3QKJ7
names: Function
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

9595:CLCA1
gene id: 9595:CLCA1
uniprot id: G3R7X0
names: Similarity
messages: Belongs to the CLCR family.

9595:MOCS1
gene id: 9595:MOCS1
uniprot id: G3R0Q1
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9595:IPPK
gene id: 9595:IPPK
uniprot id: G3QMV0
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9595:TUBB6
gene id: 9595:TUBB6
uniprot id: A0A2I2YTU3
uniprot id: G3QLA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9595:GRHL3
gene id: 9595:GRHL3
uniprot id: A0A2I2ZI75
uniprot id: G3SJB7
names: Subcellular Location Annotation
messages: Nucleus

9595:B3GNT7
gene id: 9595:B3GNT7
uniprot id: G3R4F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:RNF185
gene id: 9595:RNF185
uniprot id: G3S997
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9595:TBK1
gene id: 9595:TBK1
uniprot id: G3S8G6
names: Subcellular Location Annotation
messages: Cytoplasm

9595:GNGT2
gene id: 9595:GNGT2
uniprot id: G3QHT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9595:TASP1
gene id: 9595:TASP1
uniprot id: A0A2I2Y4V4
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9595:TMEM45B
gene id: 9595:TMEM45B
uniprot id: G3S4Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9595:PON2
gene id: 9595:PON2
uniprot id: G3RXU5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9595:ARRB1
gene id: 9595:ARRB1
uniprot id: A0A2I2ZB40
uniprot id: G3R2M1
names: Similarity
messages: Belongs to the arrestin family.

9595:CAP1
gene id: 9595:CAP1
uniprot id: A0A2I2ZQK8
uniprot id: G3SA10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9595:AMOTL1
gene id: 9595:AMOTL1
uniprot id: A0A2I2Y6D1
uniprot id: G3RXQ2
names: Similarity
messages: Belongs to the angiomotin family.

9595:OPLAH
gene id: 9595:OPLAH
uniprot id: G3RIV3
names: Similarity
messages: Belongs to the oxoprolinase family.

9595:NAGLU
gene id: 9595:NAGLU
uniprot id: G3R5I9
names: Subcellular Location Annotation
messages: Lysosome

9595:INS
gene id: 9595:INS
uniprot id: Q6YK33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

9595:ANK2
gene id: 9595:ANK2
uniprot id: A0A2I2Y5T8
uniprot id: G3S4C5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9595:ASXL2
gene id: 9595:ASXL2
uniprot id: G3R5Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9595:EVX2
gene id: 9595:EVX2
uniprot id: G3S455
names: Subcellular Location Annotation
messages: Nucleus

9595:CD320
gene id: 9595:CD320
uniprot id: G3QF47
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SLC1A2
gene id: 9595:SLC1A2
uniprot id: A0A2I2Y9Z5
uniprot id: A0A2I2ZRF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9595:CXCL10
gene id: 9595:CXCL10
uniprot id: G3R4U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:LRRC51
gene id: 9595:LRRC51
uniprot id: A0A2I2YY39
uniprot id: A0A2I2ZB38
names: Subcellular Location Annotation
messages: Cytoplasm

9595:SLC25A36
gene id: 9595:SLC25A36
uniprot id: G3SAY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:ADA2
gene id: 9595:ADA2
uniprot id: A0A2I2YCW0
uniprot id: G3QXR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

9595:IL4
gene id: 9595:IL4
uniprot id: G3QSC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
messages: Secreted

9595:CEP162
gene id: 9595:CEP162
uniprot id: G3QWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

9595:TMED4
gene id: 9595:TMED4
uniprot id: G3R8N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:ZNF174
gene id: 9595:ZNF174
uniprot id: A0A2I2Y8Q0
uniprot id: G3RJY5
names: Subcellular Location Annotation
messages: Nucleus

9595:IRX3
gene id: 9595:IRX3
uniprot id: G3RDV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9595:P2RY2
gene id: 9595:P2RY2
uniprot id: G3RAV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TSR2
gene id: 9595:TSR2
uniprot id: A0A2I2YKB2
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9595:LCE3B
gene id: 9595:LCE3B
uniprot id: G3QIF5
names: Similarity
messages: Belongs to the LCE family.

9595:ALKBH2
gene id: 9595:ALKBH2
uniprot id: G3RZ41
names: Similarity
messages: Belongs to the alkB family.

9595:SGCA
gene id: 9595:SGCA
uniprot id: G3RBL8
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

9595:CHMP4C
gene id: 9595:CHMP4C
uniprot id: G3RKJ9
names: Similarity
messages: Belongs to the SNF7 family.

9595:TYROBP
gene id: 9595:TYROBP
uniprot id: G3RH46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9595:PFDN1
gene id: 9595:PFDN1
uniprot id: A0A2I2ZB60
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9595:TMEM254
gene id: 9595:TMEM254
uniprot id: G3RTF8
names: Subcellular Location Annotation
messages: Membrane

9595:SCARB2
gene id: 9595:SCARB2
uniprot id: A0A2I2Y3T2
names: Similarity
messages: Belongs to the CD36 family.

9595:TAS1R2
gene id: 9595:TAS1R2
uniprot id: G3QS00
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:NLK
gene id: 9595:NLK
uniprot id: G3S5N7
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9595:ABL1
gene id: 9595:ABL1
uniprot id: G3R4W2
uniprot id: G3RSE2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9595:INTS9
gene id: 9595:INTS9
uniprot id: G3SJ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

9595:ST6GALNAC2
gene id: 9595:ST6GALNAC2
uniprot id: G3R968
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:STAB1
gene id: 9595:STAB1
uniprot id: G3RM17
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:AKAP4
gene id: 9595:AKAP4
uniprot id: A0A2I2ZY16
uniprot id: G3RJC1
names: Similarity
messages: Belongs to the AKAP110 family.

9595:ROPN1B
gene id: 9595:ROPN1B
uniprot id: G3QVB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

9595:MED24
gene id: 9595:MED24
uniprot id: G3QQT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9595:CHRDL1
gene id: 9595:CHRDL1
uniprot id: G3QJ73
names: Subcellular Location Annotation
messages: Secreted

9595:PARP10
gene id: 9595:PARP10
uniprot id: G3QHE9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:LOC101130739
gene id: 9595:LOC101130739
uniprot id: G3RH94
names: Similarity
messages: Belongs to the peptidase M16 family.

9595:CNDP2
gene id: 9595:CNDP2
uniprot id: G3RKV3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9595:DLX2
gene id: 9595:DLX2
uniprot id: G3QRE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9595:GLIPR1
gene id: 9595:GLIPR1
uniprot id: G3RCM0
names: Similarity
messages: Belongs to the CRISP family.

9595:B3GAT3
gene id: 9595:B3GAT3
uniprot id: A0A2I2YF45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:VPS36
gene id: 9595:VPS36
uniprot id: G3QYH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9595:SMPDL3B
gene id: 9595:SMPDL3B
uniprot id: G3RG15
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9595:MDM2
gene id: 9595:MDM2
uniprot id: A0A2I2ZWM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9595:NPBWR2
gene id: 9595:NPBWR2
uniprot id: G3QHJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101151886
gene id: 9595:LOC101151886
uniprot id: G3QRJ6
names: Similarity
messages: Belongs to the CD200R family.

9595:GPR156
gene id: 9595:GPR156
uniprot id: A0A2I2Y5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:UBB
gene id: 9595:UBB
uniprot id: P0CG67
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
messages: For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
messages: Interacts with SKP1-KMD2A and SKP1-KMD2B complexes.
messages: Mitochondrion outer membrane
messages: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.
messages: Nucleus
messages: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.
messages: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

9595:LOC101125649
gene id: 9595:LOC101125649
uniprot id: A0A2I2YP41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101151331
gene id: 9595:LOC101151331
uniprot id: G3QHX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
messages: Involved in the presentation of foreign antigens to the immune system.

9595:S100A4
gene id: 9595:S100A4
uniprot id: G3QWC6
names: Similarity
messages: Belongs to the S-100 family.

9595:LOC101146547
gene id: 9595:LOC101146547
uniprot id: G3RJ46
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC26A4
gene id: 9595:SLC26A4
uniprot id: G3SKH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

9595:EIF2S1
gene id: 9595:EIF2S1
uniprot id: G3QGW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9595:NPR2
gene id: 9595:NPR2
uniprot id: G3R6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9595:TNMD
gene id: 9595:TNMD
uniprot id: G3RLF4
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9595:PPIA
gene id: 9595:PPIA
uniprot id: Q0ZQL0
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).
messages: Cytoplasm
messages: Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).
messages: Nucleus
messages: Secreted

9595:UBA3
gene id: 9595:UBA3
uniprot id: A0A2I2ZDY8
uniprot id: G3QMY7
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9595:IMPG2
gene id: 9595:IMPG2
uniprot id: G3RJ49
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

9595:VIPAS39
gene id: 9595:VIPAS39
uniprot id: G3RK70
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9595:EXOC3L4
gene id: 9595:EXOC3L4
uniprot id: G3RKM6
names: Similarity
messages: Belongs to the SEC6 family.

9595:AGA
gene id: 9595:AGA
uniprot id: G3QX96
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9595:POFUT1
gene id: 9595:POFUT1
uniprot id: G3RAS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 65 family.
messages: Endoplasmic reticulum

9595:DLL4
gene id: 9595:DLL4
uniprot id: G3SK70
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9595:SDHAF3
gene id: 9595:SDHAF3
uniprot id: G3RFT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9595:SLFN11
gene id: 9595:SLFN11
uniprot id: G3SKH2
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9595:GPM6B
gene id: 9595:GPM6B
uniprot id: A0A2I2Y331
uniprot id: A0A2I2YQZ7
uniprot id: G3REG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9595:SCFD1
gene id: 9595:SCFD1
uniprot id: G3R600
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9595:ST13
gene id: 9595:ST13
uniprot id: G3S180
names: Similarity
messages: Belongs to the FAM10 family.

9595:DYNLL2
gene id: 9595:DYNLL2
uniprot id: A0A2I2ZQA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9595:C1H1orf74
gene id: 9595:C1H1orf74
uniprot id: G3QTP0
names: Similarity
messages: Belongs to the UPF0739 family.

9595:TSN
gene id: 9595:TSN
uniprot id: G3QIH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9595:NCK1
gene id: 9595:NCK1
uniprot id: G3SC98
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9595:TTI2
gene id: 9595:TTI2
uniprot id: A0A2I2Z055
uniprot id: G3R4N2
names: Similarity
messages: Belongs to the TTI2 family.

9595:NAA11
gene id: 9595:NAA11
uniprot id: G3RAZ1
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9595:SLC15A2
gene id: 9595:SLC15A2
uniprot id: G3R7I5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9595:EXOSC1
gene id: 9595:EXOSC1
uniprot id: G3QKR7
names: Subcellular Location Annotation
messages: Cytoplasm

9595:LOC109029337
gene id: 9595:LOC109029337
uniprot id: A0A2I2Y872
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9595:IER2
gene id: 9595:IER2
uniprot id: A0A2I2Z5D6
names: Similarity
messages: Belongs to the IER family.

9595:PROX1
gene id: 9595:PROX1
uniprot id: G3RGL5
names: Subcellular Location Annotation
messages: Nucleus

9595:WNT1
gene id: 9595:WNT1
uniprot id: G3R6M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:LOC101135475
gene id: 9595:LOC101135475
uniprot id: G3R9B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:OGT
gene id: 9595:OGT
uniprot id: G3RFX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9595:PGLYRP2
gene id: 9595:PGLYRP2
uniprot id: G3SBB6
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9595:TMEM54
gene id: 9595:TMEM54
uniprot id: G3QL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9595:NAV1
gene id: 9595:NAV1
uniprot id: A0A2I2Z906
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9595:SPAG7
gene id: 9595:SPAG7
uniprot id: G3R1B3
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101132158
gene id: 9595:LOC101132158
uniprot id: G3SAY3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9595:HTATSF1
gene id: 9595:HTATSF1
uniprot id: G3SAI5
names: Similarity
messages: Belongs to the HTATSF1 family.

9595:CAPZA2
gene id: 9595:CAPZA2
uniprot id: Q2IBE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity).

9595:VCAN
gene id: 9595:VCAN
uniprot id: A0A2I2YZ66
uniprot id: A0A2I2Z3I6
uniprot id: G3RJ07
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:LOC101144541
gene id: 9595:LOC101144541
uniprot id: G3QV42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9595:VIPR2
gene id: 9595:VIPR2
uniprot id: G3QWR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9595:TGM2
gene id: 9595:TGM2
uniprot id: G3RCE0
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9595:CNP
gene id: 9595:CNP
uniprot id: A0A2I2ZL34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

9595:LOC101127756
gene id: 9595:LOC101127756
uniprot id: G3SCT4
names: Similarity
messages: Belongs to the copine family.

9595:NR4A2
gene id: 9595:NR4A2
uniprot id: G3R6F3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9595:LYRM4
gene id: 9595:LYRM4
uniprot id: A0A2I2Y8E0
uniprot id: A0A2I2Z0B2
names: Similarity
messages: Belongs to the complex I LYR family.

9595:SPX
gene id: 9595:SPX
uniprot id: G3R5W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

9595:DCLRE1B
gene id: 9595:DCLRE1B
uniprot id: G3R6Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9595:NOP14
gene id: 9595:NOP14
uniprot id: A0A2I2YTS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9595:STARD5
gene id: 9595:STARD5
uniprot id: G3QR04
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9595:TLE2
gene id: 9595:TLE2
uniprot id: A0A2I2YHK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9595:NCAN
gene id: 9595:NCAN
uniprot id: G3QKF4
names: Caution
names: Similarity
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:AQP12A
gene id: 9595:AQP12A
uniprot id: G3S3X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

9595:PITX2
gene id: 9595:PITX2
uniprot id: A0A2I2ZPC2
uniprot id: G3R095
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9595:CEP57L1
gene id: 9595:CEP57L1
uniprot id: G3RG76
names: Similarity
messages: Belongs to the translokin family.

9595:SERPINA11
gene id: 9595:SERPINA11
uniprot id: G3QN70
names: Similarity
messages: Belongs to the serpin family.

9595:MAP2K2
gene id: 9595:MAP2K2
uniprot id: G3R0F2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:LOC101132466
gene id: 9595:LOC101132466
uniprot id: G3R4U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9595:CDK5RAP3
gene id: 9595:CDK5RAP3
uniprot id: G3S7B3
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9595:SESN3
gene id: 9595:SESN3
uniprot id: G3QQF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9595:CCNL1
gene id: 9595:CCNL1
uniprot id: A0A2I2ZDS2
uniprot id: G3SAX2
names: Similarity
messages: Belongs to the cyclin family.

9595:LOC101140564
gene id: 9595:LOC101140564
uniprot id: G3QKW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:GRIN2A
gene id: 9595:GRIN2A
uniprot id: G3R0C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9595:CHRNA10
gene id: 9595:CHRNA10
uniprot id: G3R215
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:INTS8
gene id: 9595:INTS8
uniprot id: G3QRQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9595:PROK2
gene id: 9595:PROK2
uniprot id: A0A2I2ZGH7
uniprot id: G3RZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9595:NUP133
gene id: 9595:NUP133
uniprot id: G3S1E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

9595:MAB21L3
gene id: 9595:MAB21L3
uniprot id: G3QIQ7
names: Similarity
messages: Belongs to the mab-21 family.

9595:SAR1A
gene id: 9595:SAR1A
uniprot id: G3S6V8
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9595:MCM10
gene id: 9595:MCM10
uniprot id: A0A2I2ZA30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

9595:KCNC4
gene id: 9595:KCNC4
uniprot id: G3SH62
names: Subcellular Location Annotation
messages: Membrane

9595:ACAT2
gene id: 9595:ACAT2
uniprot id: G3RDU7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9595:TLCD3A
gene id: 9595:TLCD3A
uniprot id: G3RHK4
names: Subcellular Location Annotation
messages: Membrane

9595:GPR161
gene id: 9595:GPR161
uniprot id: A0A2I2Z0H8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:AASDH
gene id: 9595:AASDH
uniprot id: G3S7P1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:RSPO1
gene id: 9595:RSPO1
uniprot id: G3QXJ8
names: Similarity
messages: Belongs to the R-spondin family.

9595:ZNRF3
gene id: 9595:ZNRF3
uniprot id: G3SG16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

9595:STOML1
gene id: 9595:STOML1
uniprot id: G3RFS7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9595:EEF1A1
gene id: 9595:EEF1A1
uniprot id: G3S518
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9595:IL2
gene id: 9595:IL2
uniprot id: G3S1Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9595:API5
gene id: 9595:API5
uniprot id: A0A2I2YNY1
names: Similarity
messages: Belongs to the API5 family.

9595:DBX1
gene id: 9595:DBX1
uniprot id: G3RFV5
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC28A1
gene id: 9595:SLC28A1
uniprot id: G3SDJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9595:KDM4D
gene id: 9595:KDM4D
uniprot id: G3R3M4
names: Subcellular Location Annotation
messages: Nucleus

9595:EMG1
gene id: 9595:EMG1
uniprot id: G3QNS9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9595:NCBP1
gene id: 9595:NCBP1
uniprot id: G3QGA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9595:ACTL6A
gene id: 9595:ACTL6A
uniprot id: G3RI40
names: Similarity
messages: Belongs to the actin family.

9595:SLC16A4
gene id: 9595:SLC16A4
uniprot id: A0A2I2YLD9
uniprot id: G3RJW7
names: Subcellular Location Annotation
messages: Membrane

9595:EFS
gene id: 9595:EFS
uniprot id: G3RLP9
names: Similarity
messages: Belongs to the CAS family.

9595:LYVE1
gene id: 9595:LYVE1
uniprot id: G3SG32
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ZNF75D
gene id: 9595:ZNF75D
uniprot id: A0A2I2Z4A5
names: Subcellular Location Annotation
messages: Nucleus

9595:MYH4
gene id: 9595:MYH4
uniprot id: G3R1E5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:PRCP
gene id: 9595:PRCP
uniprot id: G3RZ16
names: Similarity
messages: Belongs to the peptidase S28 family.

9595:EPC2
gene id: 9595:EPC2
uniprot id: G3R6Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9595:PARP3
gene id: 9595:PARP3
uniprot id: A0A2I2Z4X0
uniprot id: G3R9R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9595:AMER3
gene id: 9595:AMER3
uniprot id: G3QSD0
names: Similarity
messages: Belongs to the Amer family.

9595:PDLIM3
gene id: 9595:PDLIM3
uniprot id: A0A2I2ZNC2
names: Subcellular Location Annotation
messages: Z line

9595:CDC42BPA
gene id: 9595:CDC42BPA
uniprot id: A0A2I2Y6T2
uniprot id: A0A2I2ZFG1
uniprot id: A0A2I2ZUM1
uniprot id: G3SI75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9595:IL22
gene id: 9595:IL22
uniprot id: G3R0Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

9595:SMC5
gene id: 9595:SMC5
uniprot id: A0A2I2ZDE4
uniprot id: G3RKD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9595:ESRRG
gene id: 9595:ESRRG
uniprot id: G3R425
uniprot id: G3R430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9595:UCP1
gene id: 9595:UCP1
uniprot id: G3RQZ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

9595:SLC7A14
gene id: 9595:SLC7A14
uniprot id: A0A2I2Y2E8
names: Subcellular Location Annotation
messages: Membrane

9595:CPLANE2
gene id: 9595:CPLANE2
uniprot id: G3QNW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9595:XYLB
gene id: 9595:XYLB
uniprot id: G3RGB6
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9595:BOD1
gene id: 9595:BOD1
uniprot id: G3R5R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

9595:CASR
gene id: 9595:CASR
uniprot id: G3RWV3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:PRICKLE2
gene id: 9595:PRICKLE2
uniprot id: G3QVK9
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9595:CAMKMT
gene id: 9595:CAMKMT
uniprot id: A0A2I2Z1G4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:LOC101126372
gene id: 9595:LOC101126372
uniprot id: A0A2I2YM82
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:DEFA4
gene id: 9595:DEFA4
uniprot id: G3R5N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9595:DNAJA2
gene id: 9595:DNAJA2
uniprot id: G3RTX7
names: Subcellular Location Annotation
messages: Membrane

9595:CEP20
gene id: 9595:CEP20
uniprot id: A0A2I2YNC7
uniprot id: A0A2I2ZGE5
uniprot id: G3SEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9595:LOC101139203
gene id: 9595:LOC101139203
uniprot id: G3QQ13
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9595:LEPROT
gene id: 9595:LEPROT
uniprot id: A0A2I2Z0W5
uniprot id: A0A2I2Z5S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9595:SLCO1C1
gene id: 9595:SLCO1C1
uniprot id: G3RFA7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:IRF2
gene id: 9595:IRF2
uniprot id: G3RK92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9595:SSR1
gene id: 9595:SSR1
uniprot id: G3RQC7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9595:LOC101123970
gene id: 9595:LOC101123970
uniprot id: G3QUG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9595:GLCE
gene id: 9595:GLCE
uniprot id: G3RKT8
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9595:KRT77
gene id: 9595:KRT77
uniprot id: G3SAV9
names: Similarity
messages: Belongs to the intermediate filament family.

9595:CD163
gene id: 9595:CD163
uniprot id: A0A2I2ZPE3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SIX5
gene id: 9595:SIX5
uniprot id: G3SBS4
names: Subcellular Location Annotation
messages: Nucleus

9595:SCN3B
gene id: 9595:SCN3B
uniprot id: G3QXH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9595:DACT1
gene id: 9595:DACT1
uniprot id: G3RRC9
names: Similarity
messages: Belongs to the dapper family.

9595:SLC1A5
gene id: 9595:SLC1A5
uniprot id: G3R0B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9595:AOC2
gene id: 9595:AOC2
uniprot id: G3QY85
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9595:CACNB3
gene id: 9595:CACNB3
uniprot id: A0A2I2YK89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9595:FAM241B
gene id: 9595:FAM241B
uniprot id: G3QIE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9595:MED27
gene id: 9595:MED27
uniprot id: A0A2I2YFN3
uniprot id: A0A2I2ZIL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:P2RX1
gene id: 9595:P2RX1
uniprot id: G3S4B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9595:LOC101134521
gene id: 9595:LOC101134521
uniprot id: G3R462
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9595:PGC
gene id: 9595:PGC
uniprot id: G3QJP9
names: Similarity
messages: Belongs to the peptidase A1 family.

9595:WNT10B
gene id: 9595:WNT10B
uniprot id: G3R6M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:SYCP2
gene id: 9595:SYCP2
uniprot id: A0A2I2YZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYCP2 family.
messages: Nucleus

9595:LDLR
gene id: 9595:LDLR
uniprot id: A0A2I2YUC0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:MOB3B
gene id: 9595:MOB3B
uniprot id: G3QPL3
names: Similarity
messages: Belongs to the MOB1/phocein family.

9595:LOC101127471
gene id: 9595:LOC101127471
uniprot id: G3RQ60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PEBP1
gene id: 9595:PEBP1
uniprot id: G3RBU0
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9595:SIDT1
gene id: 9595:SIDT1
uniprot id: G3RJW2
uniprot id: G3S099
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9595:ATL1
gene id: 9595:ATL1
uniprot id: A0A2I2Z073
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:CENPO
gene id: 9595:CENPO
uniprot id: A0A2I2YWJ9
uniprot id: A0A2I2ZC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9595:GPC6
gene id: 9595:GPC6
uniprot id: G3S143
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9595:DEFB113
gene id: 9595:DEFB113
uniprot id: G3SAD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:ALDH3A2
gene id: 9595:ALDH3A2
uniprot id: G3QXF5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:MAN2A1
gene id: 9595:MAN2A1
uniprot id: G3QGR6
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9595:PSMC5
gene id: 9595:PSMC5
uniprot id: G3QV98
names: Similarity
messages: Belongs to the AAA ATPase family.

9595:PGR
gene id: 9595:PGR
uniprot id: A7X8B7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2-MAPK. Interacts with PRMT2. Interacts with NCOA2 and NCOA1. Interacts with KLF9. Interacts with GTF2B (By similarity).
messages: Nucleus
messages: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).
messages: Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1 (By similarity).
messages: Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294 (By similarity).
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
messages: Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294 (By similarity).

9595:GPN1
gene id: 9595:GPN1
uniprot id: G3RH01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

9595:ATP5F1A
gene id: 9595:ATP5F1A
uniprot id: G3RK98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9595:AFG1L
gene id: 9595:AFG1L
uniprot id: G3QNP4
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9595:MRPL33
gene id: 9595:MRPL33
uniprot id: A0A2I2YQY9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9595:SLC26A6
gene id: 9595:SLC26A6
uniprot id: A0A2I2Y4N0
uniprot id: G3SBK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9595:ZW10
gene id: 9595:ZW10
uniprot id: G3RUL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

9595:CCL11
gene id: 9595:CCL11
uniprot id: A0A2I2ZAI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:PLSCR5
gene id: 9595:PLSCR5
uniprot id: G3RZ11
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9595:TSPAN1
gene id: 9595:TSPAN1
uniprot id: G3S2H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:ACKR1
gene id: 9595:ACKR1
uniprot id: Q95LF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

9595:RALYL
gene id: 9595:RALYL
uniprot id: A0A2I2ZTI4
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9595:ATAD2
gene id: 9595:ATAD2
uniprot id: G3R1V2
names: Similarity
messages: Belongs to the AAA ATPase family.

9595:EPS8
gene id: 9595:EPS8
uniprot id: G3S4A2
names: Similarity
messages: Belongs to the EPS8 family.

9595:ECI1
gene id: 9595:ECI1
uniprot id: G3RED3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9595:TMEM216
gene id: 9595:TMEM216
uniprot id: G3RZ04
names: Subcellular Location Annotation
messages: Membrane

9595:SCD5
gene id: 9595:SCD5
uniprot id: A0A2I2YTX0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9595:IFI6
gene id: 9595:IFI6
uniprot id: G3QER5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9595:AADACL3
gene id: 9595:AADACL3
uniprot id: G3S7Q3
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9595:SFRP2
gene id: 9595:SFRP2
uniprot id: G3QH51
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PRKAR1A
gene id: 9595:PRKAR1A
uniprot id: G3RK51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9595:LMX1A
gene id: 9595:LMX1A
uniprot id: G3QL82
names: Subcellular Location Annotation
messages: Nucleus

9595:INCENP
gene id: 9595:INCENP
uniprot id: A0A2I2Z5V9
uniprot id: G3S276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

9595:RPAIN
gene id: 9595:RPAIN
uniprot id: A0A2I2YA76
uniprot id: A0A2I2YLB4
uniprot id: A0A2I2ZV45
uniprot id: G3QJU6
names: Subcellular Location Annotation
messages: Nucleus

9595:PDHA1
gene id: 9595:PDHA1
uniprot id: A0A2I2Y5G2
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9595:FBXO46
gene id: 9595:FBXO46
uniprot id: G3RWS6
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9595:DYNLRB2
gene id: 9595:DYNLRB2
uniprot id: A0A2I2ZFJ8
uniprot id: G3R016
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9595:MAL2
gene id: 9595:MAL2
uniprot id: A0A2I2YFT4
names: Subcellular Location Annotation
messages: Membrane

9595:HEATR5A
gene id: 9595:HEATR5A
uniprot id: G3QEF3
names: Similarity
messages: Belongs to the HEATR5 family.

9595:MOB1B
gene id: 9595:MOB1B
uniprot id: G3QLF3
names: Similarity
messages: Belongs to the MOB1/phocein family.

9595:ANO5
gene id: 9595:ANO5
uniprot id: G3RKI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9595:SCP2
gene id: 9595:SCP2
uniprot id: A0A2I2YEU2
uniprot id: G3R735
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion

9595:CTSV
gene id: 9595:CTSV
uniprot id: G3S2T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9595:SCNN1A
gene id: 9595:SCNN1A
uniprot id: G3R5I8
names: Subcellular Location Annotation
messages: Membrane

9595:ARL11
gene id: 9595:ARL11
uniprot id: G3QP69
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9595:MMP20
gene id: 9595:MMP20
uniprot id: G3QLA8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:TUB
gene id: 9595:TUB
uniprot id: A0A2I2YZ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9595:JPH2
gene id: 9595:JPH2
uniprot id: G3QUZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9595:ACOT8
gene id: 9595:ACOT8
uniprot id: G3QKM8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9595:EFEMP1
gene id: 9595:EFEMP1
uniprot id: G3RW79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ALDOA
gene id: 9595:ALDOA
uniprot id: A0A2I2Z8Q3
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9595:SOGA3
gene id: 9595:SOGA3
uniprot id: G3QCT0
names: Similarity
messages: Belongs to the SOGA family.

9595:LOC101150653
gene id: 9595:LOC101150653
uniprot id: G3S1W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CALHM3
gene id: 9595:CALHM3
uniprot id: G3R7N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9595:MPHOSPH8
gene id: 9595:MPHOSPH8
uniprot id: G3QSY3
names: Subcellular Location Annotation
messages: Nucleus

9595:TAMM41
gene id: 9595:TAMM41
uniprot id: A0A2I2YPY6
uniprot id: A0A2I2YYF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9595:LOC101133386
gene id: 9595:LOC101133386
uniprot id: G3RUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:LBX1
gene id: 9595:LBX1
uniprot id: G3R9W2
names: Subcellular Location Annotation
messages: Nucleus

9595:SFRP5
gene id: 9595:SFRP5
uniprot id: G3RA14
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RPL39
gene id: 9595:RPL39
uniprot id: G3QXV4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9595:TAX1BP3
gene id: 9595:TAX1BP3
uniprot id: G3R350
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9595:DEFB110
gene id: 9595:DEFB110
uniprot id: G3QG52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:LOC101132614
gene id: 9595:LOC101132614
uniprot id: G3S2U1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:TM4SF19
gene id: 9595:TM4SF19
uniprot id: A0A2I2Y6E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9595:UBE2G2
gene id: 9595:UBE2G2
uniprot id: A0A2I2Z165
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:ZKSCAN2
gene id: 9595:ZKSCAN2
uniprot id: G3SJK0
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9595:PDX1
gene id: 9595:PDX1
uniprot id: A1YF08
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3' (By similarity).
messages: Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.
messages: Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity).
messages: Nucleus
messages: Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-269 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity).
messages: The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter.
messages: The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y).
messages: cytosol

9595:GMFB
gene id: 9595:GMFB
uniprot id: A0A2I2Z891
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9595:UGT8
gene id: 9595:UGT8
uniprot id: G3S0Z3
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9595:TDRD9
gene id: 9595:TDRD9
uniprot id: G3QEV0
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

9595:FRAS1
gene id: 9595:FRAS1
uniprot id: G3QKZ2
names: Similarity
messages: Belongs to the FRAS1 family.

9595:KRT39
gene id: 9595:KRT39
uniprot id: G3RLK1
names: Similarity
messages: Belongs to the intermediate filament family.

9595:MTFR2
gene id: 9595:MTFR2
uniprot id: G3R0V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9595:CTSB
gene id: 9595:CTSB
uniprot id: G3QFS2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9595:BCO1
gene id: 9595:BCO1
uniprot id: G3QDC3
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

9595:DPT
gene id: 9595:DPT
uniprot id: G3QLX5
names: Similarity
messages: Belongs to the dermatopontin family.

9595:GDPGP1
gene id: 9595:GDPGP1
uniprot id: G3SK14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9595:SNRPD2
gene id: 9595:SNRPD2
uniprot id: G3QIU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: cytosol

9595:MMP19
gene id: 9595:MMP19
uniprot id: G3RBP6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:CTC1
gene id: 9595:CTC1
uniprot id: G3QK61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9595:NKAP
gene id: 9595:NKAP
uniprot id: G3RBY6
names: Similarity
messages: Belongs to the NKAP family.

9595:LOC101124279
gene id: 9595:LOC101124279
uniprot id: G3S2N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9595:TXNL4A
gene id: 9595:TXNL4A
uniprot id: G3QRD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9595:S1PR3
gene id: 9595:S1PR3
uniprot id: A0A2I2YLG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:AMIGO2
gene id: 9595:AMIGO2
uniprot id: A0A2I2ZSR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9595:ABI2
gene id: 9595:ABI2
uniprot id: A0A2I2ZFI4
uniprot id: A0A2I2ZKM8
uniprot id: A0A2I2ZWH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9595:PADI1
gene id: 9595:PADI1
uniprot id: G3RGE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9595:APOL6
gene id: 9595:APOL6
uniprot id: G3QPC4
names: Similarity
messages: Belongs to the apolipoprotein L family.

9595:FMNL3
gene id: 9595:FMNL3
uniprot id: A0A2I2YRC4
uniprot id: G3QGU8
names: Similarity
messages: Belongs to the formin homology family.

9595:RAMAC
gene id: 9595:RAMAC
uniprot id: G3RMB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAM family.
messages: Nucleus

9595:ARF4
gene id: 9595:ARF4
uniprot id: G3QDH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9595:GLRA2
gene id: 9595:GLRA2
uniprot id: A0A2I2ZB89
uniprot id: G3RA84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9595:TEX28
gene id: 9595:TEX28
uniprot id: G3QNJ2
names: Similarity
messages: Belongs to the TEX28 family.

9595:SLC8A1
gene id: 9595:SLC8A1
uniprot id: A0A2I2YRZ6
uniprot id: A0A2I2ZY48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9595:AKAP12
gene id: 9595:AKAP12
uniprot id: A0A2I2Y3L9
uniprot id: A0A2I2ZCZ8
uniprot id: G3RQR0
names: Subcellular Location Annotation
messages: Membrane

9595:RUNX3
gene id: 9595:RUNX3
uniprot id: G3S3J4
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9595:NCL
gene id: 9595:NCL
uniprot id: G3QNU5
names: Function
names: Subcellular Location Annotation
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
messages: nucleolus

9595:EBPL
gene id: 9595:EBPL
uniprot id: G3RQ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:TOMM20L
gene id: 9595:TOMM20L
uniprot id: G3QH89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:IREB2
gene id: 9595:IREB2
uniprot id: G3RHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

9595:MAPK8IP3
gene id: 9595:MAPK8IP3
uniprot id: G3QTQ8
uniprot id: G3RYQ6
names: Similarity
messages: Belongs to the JIP scaffold family.

9595:HOXD1
gene id: 9595:HOXD1
uniprot id: G3S0K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9595:RSBN1
gene id: 9595:RSBN1
uniprot id: G3QMN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9595:SLC37A1
gene id: 9595:SLC37A1
uniprot id: G3R8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9595:BECN1
gene id: 9595:BECN1
uniprot id: G3QGV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9595:FAAH
gene id: 9595:FAAH
uniprot id: G3RF81
names: Similarity
messages: Belongs to the amidase family.

9595:E2F8
gene id: 9595:E2F8
uniprot id: G3S6E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:NNAT
gene id: 9595:NNAT
uniprot id: A0A2I2ZHK7
uniprot id: G3QPM1
names: Similarity
messages: Belongs to the neuronatin family.

9595:GPC3
gene id: 9595:GPC3
uniprot id: A0A2I2ZY02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9595:NLGN3
gene id: 9595:NLGN3
uniprot id: A0A2I2Y1Q6
uniprot id: A0A2I2YXQ3
uniprot id: G3RBW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9595:CISD2
gene id: 9595:CISD2
uniprot id: G3QGA2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CISD protein family. CISD2 subfamily.
messages: Binds 1 [2Fe-2S] cluster.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Mitochondrion outer membrane
messages: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy.

9595:TIPARP
gene id: 9595:TIPARP
uniprot id: G3RX27
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:MAT1A
gene id: 9595:MAT1A
uniprot id: G3QSU0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9595:MTHFS
gene id: 9595:MTHFS
uniprot id: A0A2I2ZGX5
uniprot id: G3R914
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

9595:HPS6
gene id: 9595:HPS6
uniprot id: G3R0K6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9595:CCN4
gene id: 9595:CCN4
uniprot id: A0A2I2Z7K7
uniprot id: G3RGS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:USP26
gene id: 9595:USP26
uniprot id: G3SHA9
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:ZBED1
gene id: 9595:ZBED1
uniprot id: G3R7R6
names: Subcellular Location Annotation
messages: Nucleus

9595:SUSD3
gene id: 9595:SUSD3
uniprot id: A0A2I2ZUS1
uniprot id: G3R0M6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:GJB1
gene id: 9595:GJB1
uniprot id: G3R5C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:LOC101136257
gene id: 9595:LOC101136257
uniprot id: G3SHJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:NEUROD4
gene id: 9595:NEUROD4
uniprot id: G3QNT6
names: Subcellular Location Annotation
messages: Nucleus

9595:ROMO1
gene id: 9595:ROMO1
uniprot id: A0A2I2ZHZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9595:LOC101124249
gene id: 9595:LOC101124249
uniprot id: G3R2I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9595:TCN2
gene id: 9595:TCN2
uniprot id: G3QD18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9595:SEPTIN4
gene id: 9595:SEPTIN4
uniprot id: A0A2I2ZB66
uniprot id: G3RD82
uniprot id: G3RN19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9595:KIF21B
gene id: 9595:KIF21B
uniprot id: A0A2I2ZHH3
uniprot id: G3S6F9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:CDK15
gene id: 9595:CDK15
uniprot id: A0A2I2YJ08
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:HTR1F
gene id: 9595:HTR1F
uniprot id: A0A2I2YK37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

9595:LOC101130426
gene id: 9595:LOC101130426
uniprot id: G3RHP6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:PSME2
gene id: 9595:PSME2
uniprot id: G3S8N8
names: Similarity
messages: Belongs to the PA28 family.

9595:PDSS2
gene id: 9595:PDSS2
uniprot id: A0A2I2ZV98
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9595:METAP2
gene id: 9595:METAP2
uniprot id: G3R026
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9595:SAP18
gene id: 9595:SAP18
uniprot id: G3RF20
names: Similarity
messages: Belongs to the SAP18 family.

9595:XPC
gene id: 9595:XPC
uniprot id: G3R3D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

9595:LOC101132732
gene id: 9595:LOC101132732
uniprot id: G3QQ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:RFC4
gene id: 9595:RFC4
uniprot id: A0A2I2Y7Y2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9595:PSPC1
gene id: 9595:PSPC1
uniprot id: G3QLK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSPC family.
messages: Cytoplasm
messages: Nucleus matrix
messages: Nucleus speckle
messages: nucleolus

9595:BBS2
gene id: 9595:BBS2
uniprot id: G3RIZ2
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9595:SMO
gene id: 9595:SMO
uniprot id: G3QL33
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium

9595:PYCARD
gene id: 9595:PYCARD
uniprot id: G3RLS4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9595:PPM1K
gene id: 9595:PPM1K
uniprot id: G3QJW6
names: Similarity
messages: Belongs to the PP2C family.

9595:KLHL3
gene id: 9595:KLHL3
uniprot id: G3S417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KLHL3 family.
messages: cytoskeleton
messages: cytosol

9595:SCRN1
gene id: 9595:SCRN1
uniprot id: G3QSH3
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9595:RIMKLA
gene id: 9595:RIMKLA
uniprot id: G3S078
names: Similarity
messages: Belongs to the RimK family.

9595:SLC5A7
gene id: 9595:SLC5A7
uniprot id: G3QXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9595:TMC8
gene id: 9595:TMC8
uniprot id: G3QVS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9595:FAM98A
gene id: 9595:FAM98A
uniprot id: G3SJ47
names: Similarity
messages: Belongs to the FAM98 family.

9595:DMTF1
gene id: 9595:DMTF1
uniprot id: G3QJY1
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101131776
gene id: 9595:LOC101131776
uniprot id: G3RDZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:CCL7
gene id: 9595:CCL7
uniprot id: G3QPB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:FNBP1L
gene id: 9595:FNBP1L
uniprot id: A0A2I2YEJ0
uniprot id: G3S9L3
uniprot id: G3SIM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9595:BET1L
gene id: 9595:BET1L
uniprot id: A0A2I2YYB2
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101143345
gene id: 9595:LOC101143345
uniprot id: G3RWP2
names: Subcellular Location Annotation
messages: Membrane

9595:RAMP1
gene id: 9595:RAMP1
uniprot id: G3RNM5
names: Similarity
messages: Belongs to the RAMP family.

9595:DNAH8
gene id: 9595:DNAH8
uniprot id: G3RF10
names: Similarity
messages: Belongs to the dynein heavy chain family.

9595:GLRX
gene id: 9595:GLRX
uniprot id: G3R1A5
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9595:SMC2
gene id: 9595:SMC2
uniprot id: A0A2I2ZG35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

9595:SERPINF1
gene id: 9595:SERPINF1
uniprot id: G3QDC6
names: Similarity
messages: Belongs to the serpin family.

9595:ADGRG3
gene id: 9595:ADGRG3
uniprot id: G3QZF8
names: Subcellular Location Annotation
messages: Membrane

9595:PPP2R2A
gene id: 9595:PPP2R2A
uniprot id: G3RM99
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9595:WASF2
gene id: 9595:WASF2
uniprot id: G3RPV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9595:MEOX1
gene id: 9595:MEOX1
uniprot id: A0A2I2ZCA0
uniprot id: G3QKL7
names: Subcellular Location Annotation
messages: Nucleus

9595:CC2D1B
gene id: 9595:CC2D1B
uniprot id: G3QD75
uniprot id: G3SJN8
names: Similarity
messages: Belongs to the CC2D1 family.

9595:GPR87
gene id: 9595:GPR87
uniprot id: A0A2I2YC71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TOP1
gene id: 9595:TOP1
uniprot id: G3R0W2
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9595:GNAI3
gene id: 9595:GNAI3
uniprot id: G3SCU6
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9595:NAPB
gene id: 9595:NAPB
uniprot id: G3QZP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9595:TET2
gene id: 9595:TET2
uniprot id: A0A2I2Y4W1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9595:LOC101139491
gene id: 9595:LOC101139491
uniprot id: G3R5M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TSPAN5
gene id: 9595:TSPAN5
uniprot id: G3SGT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:MED17
gene id: 9595:MED17
uniprot id: G3SAE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:PIK3R3
gene id: 9595:PIK3R3
uniprot id: A0A2I2Z117
uniprot id: G3R3X8
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9595:CUL2
gene id: 9595:CUL2
uniprot id: A0A2I2YYC6
names: Similarity
messages: Belongs to the cullin family.

9595:SMAD7
gene id: 9595:SMAD7
uniprot id: G3R4S9
names: Subcellular Location Annotation
messages: Nucleus

9595:ARPC5L
gene id: 9595:ARPC5L
uniprot id: G3QNC4
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9595:LOC101143702
gene id: 9595:LOC101143702
uniprot id: G3RZ81
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9595:LOC101125803
gene id: 9595:LOC101125803
uniprot id: G3SKC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9595:SRP19
gene id: 9595:SRP19
uniprot id: G3SI21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9595:LOC101152574
gene id: 9595:LOC101152574
uniprot id: G3RRM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SGK1
gene id: 9595:SGK1
uniprot id: A0A2I2YET3
uniprot id: A0A2I2YMZ6
uniprot id: G3QGL7
uniprot id: G3S3Y0
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9595:GPR37L1
gene id: 9595:GPR37L1
uniprot id: G3RQ21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:IGFBP6
gene id: 9595:IGFBP6
uniprot id: G3QKV6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:NFE2L1
gene id: 9595:NFE2L1
uniprot id: A0A2I2YX86
uniprot id: G3QIM0
uniprot id: G3SBU6
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9595:ADRA1B
gene id: 9595:ADRA1B
uniprot id: G3QHV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

9595:MRS2
gene id: 9595:MRS2
uniprot id: G3R146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

9595:NR1H3
gene id: 9595:NR1H3
uniprot id: A0A2I2ZHW6
uniprot id: G3QZS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:ORC5
gene id: 9595:ORC5
uniprot id: G3QFC8
names: Subcellular Location Annotation
messages: Nucleus

9595:RPS27
gene id: 9595:RPS27
uniprot id: G3S0D8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9595:NAF1
gene id: 9595:NAF1
uniprot id: G3QF20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

9595:SYT1
gene id: 9595:SYT1
uniprot id: G3S3Z1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9595:OBP2B
gene id: 9595:OBP2B
uniprot id: G3R204
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9595:CHURC1
gene id: 9595:CHURC1
uniprot id: A0A2I2YS44
uniprot id: A0A2I2Z3V6
names: Similarity
messages: Belongs to the Churchill family.

9595:XRCC1
gene id: 9595:XRCC1
uniprot id: A0A2I2Y8B4
names: Subcellular Location Annotation
messages: Nucleus

9595:SSBP1
gene id: 9595:SSBP1
uniprot id: G3R2E1
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9595:FAM221A
gene id: 9595:FAM221A
uniprot id: A0A2I2Y8K3
uniprot id: A0A2I2YCH6
uniprot id: G3QG28
names: Similarity
messages: Belongs to the FAM221 family.

9595:DUOX2
gene id: 9595:DUOX2
uniprot id: G3R7S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

9595:GBP6
gene id: 9595:GBP6
uniprot id: G3R5E0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:MOK
gene id: 9595:MOK
uniprot id: G3QTB2
uniprot id: G3SHC6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:HOXD4
gene id: 9595:HOXD4
uniprot id: A1YER7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: Forms a DNA-binding heterodimer with transcription factor PBX1.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9595:MRPL35
gene id: 9595:MRPL35
uniprot id: G3SB05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9595:CTSO
gene id: 9595:CTSO
uniprot id: G3RJD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9595:MARS2
gene id: 9595:MARS2
uniprot id: G3SKQ2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:TMA16
gene id: 9595:TMA16
uniprot id: G3RQG7
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9595:TBXT
gene id: 9595:TBXT
uniprot id: G3QXI2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:PAPSS2
gene id: 9595:PAPSS2
uniprot id: G3SB39
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9595:CALHM5
gene id: 9595:CALHM5
uniprot id: A0A2I2Z0T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9595:ATP6V1G1
gene id: 9595:ATP6V1G1
uniprot id: A0A2I2Z1I5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:PRDM10
gene id: 9595:PRDM10
uniprot id: G3SEU8
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9595:KCNJ1
gene id: 9595:KCNJ1
uniprot id: G3QQD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9595:BDNF
gene id: 9595:BDNF
uniprot id: A0A2I2YYY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
messages: Monomers and homodimers. Binds to NTRK2/TRKB.
messages: Secreted

9595:SLC6A1
gene id: 9595:SLC6A1
uniprot id: G3QDQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:ITGAM
gene id: 9595:ITGAM
uniprot id: G3QN92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:CSTA
gene id: 9595:CSTA
uniprot id: G3S822
names: Similarity
messages: Belongs to the cystatin family.

9595:RPL37
gene id: 9595:RPL37
uniprot id: G3SHH0
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9595:TBX4
gene id: 9595:TBX4
uniprot id: G3RDF8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:MOGAT3
gene id: 9595:MOGAT3
uniprot id: A0A2I2ZL00
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CTSC
gene id: 9595:CTSC
uniprot id: G3QI81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9595:BST1
gene id: 9595:BST1
uniprot id: G3R0G4
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9595:SELL
gene id: 9595:SELL
uniprot id: G3RND1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:MST1R
gene id: 9595:MST1R
uniprot id: A0A2I2Y2Q4
uniprot id: G3R996
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LOC101136556
gene id: 9595:LOC101136556
uniprot id: A0A2I2Z7H9
names: Subcellular Location Annotation
messages: Membrane

9595:VPS52
gene id: 9595:VPS52
uniprot id: G3QUM2
names: Similarity
messages: Belongs to the VPS52 family.

9595:TLX2
gene id: 9595:TLX2
uniprot id: G3QTX8
names: Subcellular Location Annotation
messages: Nucleus

9595:DEFB123
gene id: 9595:DEFB123
uniprot id: A4H235
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:DCTN4
gene id: 9595:DCTN4
uniprot id: A0A2I2ZYM7
uniprot id: G3R2X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: cell cortex
messages: centrosome
messages: sarcomere
messages: stress fiber

9595:SULT2A1
gene id: 9595:SULT2A1
uniprot id: G3R8Y3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:ATP2C2
gene id: 9595:ATP2C2
uniprot id: G3RHJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:CPA5
gene id: 9595:CPA5
uniprot id: G3QJ01
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:MRPL24
gene id: 9595:MRPL24
uniprot id: G3RUI4
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9595:CLK3
gene id: 9595:CLK3
uniprot id: G3RU80
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:GIPR
gene id: 9595:GIPR
uniprot id: G3RJ74
names: Subcellular Location Annotation
messages: Membrane

9595:TOM1
gene id: 9595:TOM1
uniprot id: A0A2I2ZKN0
names: Similarity
messages: Belongs to the TOM1 family.

9595:ISL2
gene id: 9595:ISL2
uniprot id: G3SG14
names: Subcellular Location Annotation
messages: Nucleus

9595:TLR9
gene id: 9595:TLR9
uniprot id: G3RIC3
uniprot id: G3RIE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane
messages: cytoskeleton
messages: phagosome

9595:GNL2
gene id: 9595:GNL2
uniprot id: G3QXJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9595:DRD5
gene id: 9595:DRD5
uniprot id: G3QY32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TRNAU1AP
gene id: 9595:TRNAU1AP
uniprot id: G3QLT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9595:OLFML2B
gene id: 9595:OLFML2B
uniprot id: G3R0H9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:UNC45B
gene id: 9595:UNC45B
uniprot id: G3SGT4
names: Subcellular Location Annotation
messages: A band
messages: Z line
messages: perinuclear region

9595:LOC101152766
gene id: 9595:LOC101152766
uniprot id: G3RN34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9595:MYO1E
gene id: 9595:MYO1E
uniprot id: G3QXE8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:GJD2
gene id: 9595:GJD2
uniprot id: G3S404
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:DUSP29
gene id: 9595:DUSP29
uniprot id: G3R603
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9595:KRT7
gene id: 9595:KRT7
uniprot id: G3QUQ0
names: Similarity
messages: Belongs to the intermediate filament family.

9595:TSC22D4
gene id: 9595:TSC22D4
uniprot id: G3SD77
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9595:MYOZ2
gene id: 9595:MYOZ2
uniprot id: G3R4I6
names: Similarity
messages: Belongs to the myozenin family.

9595:DMC1
gene id: 9595:DMC1
uniprot id: A0A2I2YX58
uniprot id: G3R6H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

9595:IDH1
gene id: 9595:IDH1
uniprot id: G3RA53
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.

9595:IRGC
gene id: 9595:IRGC
uniprot id: G3S785
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9595:BRCC3
gene id: 9595:BRCC3
uniprot id: A0A2I2Y4Q6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9595:CLNS1A
gene id: 9595:CLNS1A
uniprot id: A0A2I2Z6E0
uniprot id: G3QKQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9595:RPS21
gene id: 9595:RPS21
uniprot id: A0A2I2YYA4
uniprot id: G3S5I5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9595:GPC5
gene id: 9595:GPC5
uniprot id: G3RGF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9595:BORCS5
gene id: 9595:BORCS5
uniprot id: G3RZM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9595:CUEDC2
gene id: 9595:CUEDC2
uniprot id: G3QVR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9595:LOC101131628
gene id: 9595:LOC101131628
uniprot id: G3RRJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9595:LYPLA2
gene id: 9595:LYPLA2
uniprot id: G3QNX0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9595:FUT8
gene id: 9595:FUT8
uniprot id: G3R0L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9595:UCMA
gene id: 9595:UCMA
uniprot id: G3RE54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

9595:GRAMD1A
gene id: 9595:GRAMD1A
uniprot id: G3RV31
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LAMTOR4
gene id: 9595:LAMTOR4
uniprot id: G3S8H2
names: Similarity
messages: Belongs to the LAMTOR4 family.

9595:CAMLG
gene id: 9595:CAMLG
uniprot id: G3R3Y6
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9595:COLGALT2
gene id: 9595:COLGALT2
uniprot id: G3RC09
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9595:DIABLO
gene id: 9595:DIABLO
uniprot id: G3QRI5
names: Subcellular Location Annotation
messages: Mitochondrion

9595:TTC9
gene id: 9595:TTC9
uniprot id: G3QLS9
names: Similarity
messages: Belongs to the TTC9 family.

9595:NAV3
gene id: 9595:NAV3
uniprot id: G3SIM3
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9595:AGPAT3
gene id: 9595:AGPAT3
uniprot id: A0A2I2ZNY2
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9595:ETV6
gene id: 9595:ETV6
uniprot id: G3QGQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:CHRNB2
gene id: 9595:CHRNB2
uniprot id: G3QW49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:CDK8
gene id: 9595:CDK8
uniprot id: G3QUM8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:MED20
gene id: 9595:MED20
uniprot id: G3RJE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:AP4S1
gene id: 9595:AP4S1
uniprot id: A0A2I2Y3P3
uniprot id: G3QL05
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9595:NXT1
gene id: 9595:NXT1
uniprot id: G3R9X8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9595:TGS1
gene id: 9595:TGS1
uniprot id: G3QZW2
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9595:DDB1
gene id: 9595:DDB1
uniprot id: G3QN74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9595:ABCG2
gene id: 9595:ABCG2
uniprot id: G3QHY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9595:TYW3
gene id: 9595:TYW3
uniprot id: G3RCV6
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9595:SLC16A13
gene id: 9595:SLC16A13
uniprot id: G3QG09
names: Subcellular Location Annotation
messages: Membrane

9595:VGLL4
gene id: 9595:VGLL4
uniprot id: A0A2I2YTG3
uniprot id: A0A2I2ZKA6
uniprot id: G3QLS5
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9595:PCSK2
gene id: 9595:PCSK2
uniprot id: G3QWE4
names: Similarity
messages: Belongs to the peptidase S8 family.

9595:PLA2G12A
gene id: 9595:PLA2G12A
uniprot id: A0A2I2ZUU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9595:NCBP2
gene id: 9595:NCBP2
uniprot id: A0A2I2Z1G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9595:FZD10
gene id: 9595:FZD10
uniprot id: A0A2I2YWP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9595:LOC109028282
gene id: 9595:LOC109028282
uniprot id: A0A2I2ZES0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:DDI1
gene id: 9595:DDI1
uniprot id: G3RAE7
names: Similarity
messages: Belongs to the DDI1 family.

9595:CASTOR1
gene id: 9595:CASTOR1
uniprot id: A0A2I2Z0D1
uniprot id: G3QW74
names: Similarity
messages: Belongs to the GATS family.

9595:RBM8A
gene id: 9595:RBM8A
uniprot id: A0A2I2ZK34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9595:NDUFA5
gene id: 9595:NDUFA5
uniprot id: A0A2K5TIY8
uniprot id: Q0MQA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:XIRP1
gene id: 9595:XIRP1
uniprot id: G3RKB7
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9595:PDE1C
gene id: 9595:PDE1C
uniprot id: A0A2I2YMV7
uniprot id: A0A2I2ZTC6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:NSUN7
gene id: 9595:NSUN7
uniprot id: A0A2I2YXN1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CAPN10
gene id: 9595:CAPN10
uniprot id: G3QGL4
names: Similarity
messages: Belongs to the peptidase C2 family.

9595:DHRS11
gene id: 9595:DHRS11
uniprot id: A0A2I2YLK8
uniprot id: G3QY64
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:SLC4A3
gene id: 9595:SLC4A3
uniprot id: G3QRZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

9595:AAR2
gene id: 9595:AAR2
uniprot id: G3RWS2
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9595:CNTN1
gene id: 9595:CNTN1
uniprot id: A0A2I2YYD1
uniprot id: A0A2I2Z2F5
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9595:PITX1
gene id: 9595:PITX1
uniprot id: G3QQ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9595:MYO6
gene id: 9595:MYO6
uniprot id: A0A2I2YUX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: filopodium
messages: microvillus
messages: ruffle membrane
messages: trans-Golgi network membrane

9595:TGIF2
gene id: 9595:TGIF2
uniprot id: G3R7Z0
names: Subcellular Location Annotation
messages: Nucleus

9595:LAMC1
gene id: 9595:LAMC1
uniprot id: G3S795
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9595:SLC25A43
gene id: 9595:SLC25A43
uniprot id: G3S648
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:PRSS12
gene id: 9595:PRSS12
uniprot id: G3QK11
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

9595:LTBP1
gene id: 9595:LTBP1
uniprot id: A0A2I2ZQF7
uniprot id: G3R903
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:CREBL2
gene id: 9595:CREBL2
uniprot id: G3SGG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9595:INTS12
gene id: 9595:INTS12
uniprot id: A0A2I2Y4J6
names: Similarity
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

9595:LOC101131208
gene id: 9595:LOC101131208
uniprot id: G3QTH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:IMPG1
gene id: 9595:IMPG1
uniprot id: G3S150
names: Subcellular Location Annotation
messages: interphotoreceptor matrix

9595:AMIGO1
gene id: 9595:AMIGO1
uniprot id: G3S862
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9595:SH3RF1
gene id: 9595:SH3RF1
uniprot id: G3QD49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3RF family.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

9595:LOC101134640
gene id: 9595:LOC101134640
uniprot id: G3RIU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9595:TGFBI
gene id: 9595:TGFBI
uniprot id: G3R261
names: Subcellular Location Annotation
messages: extracellular matrix

9595:CLDND2
gene id: 9595:CLDND2
uniprot id: G3RFQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9595:CRELD1
gene id: 9595:CRELD1
uniprot id: G3RNI8
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ACMSD
gene id: 9595:ACMSD
uniprot id: G3R2J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9595:TIGD6
gene id: 9595:TIGD6
uniprot id: G3R0M8
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC35E1
gene id: 9595:SLC35E1
uniprot id: G3RJR7
names: Subcellular Location Annotation
messages: Membrane

9595:CCN5
gene id: 9595:CCN5
uniprot id: A0A2I2ZRV7
names: Similarity
messages: Belongs to the CCN family.

9595:GRPEL1
gene id: 9595:GRPEL1
uniprot id: G3RJT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9595:DRGX
gene id: 9595:DRGX
uniprot id: G3QYQ5
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101134814
gene id: 9595:LOC101134814
uniprot id: G3S4D2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:LARP7
gene id: 9595:LARP7
uniprot id: G3SFI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LARP7 family.
messages: nucleoplasm

9595:ATG9B
gene id: 9595:ATG9B
uniprot id: G3RL06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9595:LOC101148389
gene id: 9595:LOC101148389
uniprot id: G3RUZ8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9595:CCNJ
gene id: 9595:CCNJ
uniprot id: G3QT91
names: Similarity
messages: Belongs to the cyclin family.

9595:USP13
gene id: 9595:USP13
uniprot id: G3SKD8
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:DNER
gene id: 9595:DNER
uniprot id: G3RFZ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LHFPL6
gene id: 9595:LHFPL6
uniprot id: G3SAU7
names: Subcellular Location Annotation
messages: Membrane

9595:AK2
gene id: 9595:AK2
uniprot id: A0A2I2Y1Z5
uniprot id: A0A2I2ZP83
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9595:KCNMB4
gene id: 9595:KCNMB4
uniprot id: G3RAE5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9595:NKG7
gene id: 9595:NKG7
uniprot id: G3RFP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9595:SLC1A1
gene id: 9595:SLC1A1
uniprot id: G3QDE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9595:PEX7
gene id: 9595:PEX7
uniprot id: G3QJX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

9595:ANKRD13D
gene id: 9595:ANKRD13D
uniprot id: G3R6R1
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9595:LOC101124317
gene id: 9595:LOC101124317
uniprot id: G3RPV0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:CFL2
gene id: 9595:CFL2
uniprot id: G3QVF0
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9595:DEFB135
gene id: 9595:DEFB135
uniprot id: G3QZ08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:RPS14
gene id: 9595:RPS14
uniprot id: A0A2I2YH05
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9595:PPP1CC
gene id: 9595:PPP1CC
uniprot id: A0A2I2ZXW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9595:GNPNAT1
gene id: 9595:GNPNAT1
uniprot id: G3SFH5
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9595:LYNX1
gene id: 9595:LYNX1
uniprot id: A0A2I2Z8F6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:GTPBP3
gene id: 9595:GTPBP3
uniprot id: G3RHS2
uniprot id: G3S773
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9595:LOC101154372
gene id: 9595:LOC101154372
uniprot id: G3QJ38
names: Subcellular Location Annotation
messages: Membrane

9595:ZER1
gene id: 9595:ZER1
uniprot id: G3R9I9
names: Similarity
messages: Belongs to the zyg-11 family.

9595:DHX58
gene id: 9595:DHX58
uniprot id: G3QRT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9595:CCNYL1
gene id: 9595:CCNYL1
uniprot id: A0A2I2Y7M7
uniprot id: A0A2I2Z0Z9
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9595:ITGB6
gene id: 9595:ITGB6
uniprot id: A0A2I2Y7Z0
uniprot id: G3R1W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9595:GABRQ
gene id: 9595:GABRQ
uniprot id: G3RJ63
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:PLN
gene id: 9595:PLN
uniprot id: A0A2I2ZQD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

9595:UMPS
gene id: 9595:UMPS
uniprot id: G3RTQ7
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9595:SLC26A2
gene id: 9595:SLC26A2
uniprot id: G3QE35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.

9595:ZUP1
gene id: 9595:ZUP1
uniprot id: G3RKV6
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9595:RIC8B
gene id: 9595:RIC8B
uniprot id: A0A2I2YTZ8
uniprot id: A0A2I2YYP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9595:CA12
gene id: 9595:CA12
uniprot id: G3QI60
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9595:PFN2
gene id: 9595:PFN2
uniprot id: G3QW12
names: Similarity
messages: Belongs to the profilin family.

9595:CRISP1
gene id: 9595:CRISP1
uniprot id: G3R4Q7
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RGS7BP
gene id: 9595:RGS7BP
uniprot id: G3R6X3
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9595:POU5F1
gene id: 9595:POU5F1
uniprot id: G3S2Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9595:MECOM
gene id: 9595:MECOM
uniprot id: G3RBC7
names: Subcellular Location Annotation
messages: Nucleus

9595:CSAD
gene id: 9595:CSAD
uniprot id: A0A2I2ZNE2
names: Similarity
messages: Belongs to the group II decarboxylase family.

9595:BCAR1
gene id: 9595:BCAR1
uniprot id: A0A2I2YVQ0
uniprot id: G3R533
uniprot id: G3RT25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9595:LOC101147293
gene id: 9595:LOC101147293
uniprot id: G3RBS9
uniprot id: G3RW52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9595:PITHD1
gene id: 9595:PITHD1
uniprot id: G3QNW5
names: Similarity
messages: Belongs to the PITHD1 family.

9595:DEFB118
gene id: 9595:DEFB118
uniprot id: A4H220
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis (By similarity). Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes (By similarity). Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface (By similarity). Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization (By similarity). May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms (By similarity).
messages: Secreted
messages: The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for antimicrobial activity.

9595:DDX21
gene id: 9595:DDX21
uniprot id: G3QQU4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9595:RORB
gene id: 9595:RORB
uniprot id: G3S875
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:MTRF1
gene id: 9595:MTRF1
uniprot id: G3QJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9595:PON3
gene id: 9595:PON3
uniprot id: G3RBS0
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9595:GSK3A
gene id: 9595:GSK3A
uniprot id: G3QPQ5
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9595:SMIM12
gene id: 9595:SMIM12
uniprot id: A0A2I2YHE2
uniprot id: A0A2I2Z1S9
names: Similarity
messages: Belongs to the SMIM12 family.

9595:PCBD1
gene id: 9595:PCBD1
uniprot id: G3RDN1
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9595:SLC25A19
gene id: 9595:SLC25A19
uniprot id: G3S981
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:ALB
gene id: 9595:ALB
uniprot id: G3S791
names: Subcellular Location Annotation
messages: Secreted

9595:RPL37A
gene id: 9595:RPL37A
uniprot id: G3RFT4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9595:EBF1
gene id: 9595:EBF1
uniprot id: G3QCT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9595:SLC27A2
gene id: 9595:SLC27A2
uniprot id: G3QTE5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:THRB
gene id: 9595:THRB
uniprot id: G3QWF5
uniprot id: G3S6W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:PTX4
gene id: 9595:PTX4
uniprot id: G3SAG7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:EIF1AD
gene id: 9595:EIF1AD
uniprot id: G3R7Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9595:CEPT1
gene id: 9595:CEPT1
uniprot id: G3R2A9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9595:PARP15
gene id: 9595:PARP15
uniprot id: A0A2I2ZPY1
uniprot id: G3S4Z7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:S100A16
gene id: 9595:S100A16
uniprot id: G3S962
names: Similarity
messages: Belongs to the S-100 family.

9595:DENND5A
gene id: 9595:DENND5A
uniprot id: A0A2I2ZCJ1
uniprot id: G3R4D5
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PSMD4
gene id: 9595:PSMD4
uniprot id: G3QN77
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9595:AHCYL1
gene id: 9595:AHCYL1
uniprot id: A0A2I2Z1F3
uniprot id: G3R806
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9595:BARX1
gene id: 9595:BARX1
uniprot id: G3R4K0
names: Subcellular Location Annotation
messages: Nucleus

9595:NIPAL2
gene id: 9595:NIPAL2
uniprot id: G3QIX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9595:HAPSTR2
gene id: 9595:HAPSTR2
uniprot id: A0A2I2YQ82
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101152881
gene id: 9595:LOC101152881
uniprot id: G3SK33
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:CBX6
gene id: 9595:CBX6
uniprot id: A0A2I2Y460
names: Subcellular Location Annotation
messages: Nucleus

9595:CLDN20
gene id: 9595:CLDN20
uniprot id: G3QDH2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:ACOX2
gene id: 9595:ACOX2
uniprot id: G3RHE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9595:LOC101125671
gene id: 9595:LOC101125671
uniprot id: G3SGJ4
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:IFITM2
gene id: 9595:IFITM2
uniprot id: G3RRI8
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:MCM2
gene id: 9595:MCM2
uniprot id: G3RFX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9595:MPP4
gene id: 9595:MPP4
uniprot id: G3RGC7
names: Similarity
messages: Belongs to the MAGUK family.

9595:DUOXA2
gene id: 9595:DUOXA2
uniprot id: G3R7T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9595:CD1D
gene id: 9595:CD1D
uniprot id: G3R7Y4
names: Similarity
messages: Belongs to the MHC class I family.

9595:IL17F
gene id: 9595:IL17F
uniprot id: G3QQN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9595:EFNB1
gene id: 9595:EFNB1
uniprot id: G3R3A6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ERH
gene id: 9595:ERH
uniprot id: G3QPZ4
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9595:B3GNT2
gene id: 9595:B3GNT2
uniprot id: G3RQS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:TFIP11
gene id: 9595:TFIP11
uniprot id: G3QQN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9595:TXNIP
gene id: 9595:TXNIP
uniprot id: G3R848
names: Similarity
messages: Belongs to the arrestin family.

9595:BAIAP3
gene id: 9595:BAIAP3
uniprot id: G3R7P0
names: Similarity
messages: Belongs to the unc-13 family.

9595:MAST2
gene id: 9595:MAST2
uniprot id: G3RI07
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9595:MAN1A2
gene id: 9595:MAN1A2
uniprot id: G3REE6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9595:VLDLR
gene id: 9595:VLDLR
uniprot id: A0A2I2ZM49
uniprot id: G3QG94
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:GUF1
gene id: 9595:GUF1
uniprot id: G3SBM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

9595:CERT1
gene id: 9595:CERT1
uniprot id: G3QQS6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

9595:CACNG3
gene id: 9595:CACNG3
uniprot id: G3QJX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9595:GOSR2
gene id: 9595:GOSR2
uniprot id: G3RYB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9595:TP53RK
gene id: 9595:TP53RK
uniprot id: G3QI33
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

9595:SLC30A7
gene id: 9595:SLC30A7
uniprot id: A0A2I2ZEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9595:RNF175
gene id: 9595:RNF175
uniprot id: G3QYC3
names: Subcellular Location Annotation
messages: Membrane

9595:MRPL49
gene id: 9595:MRPL49
uniprot id: A0A2I2YN15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

9595:PGAP2
gene id: 9595:PGAP2
uniprot id: A0A2I2YLW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9595:RET
gene id: 9595:RET
uniprot id: G3QLZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

9595:ADGRG1
gene id: 9595:ADGRG1
uniprot id: G3QZE8
uniprot id: G3S7U6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9595:CFAP91
gene id: 9595:CFAP91
uniprot id: G3R2Z4
names: Similarity
messages: Belongs to the CFAP91 family.

9595:WIF1
gene id: 9595:WIF1
uniprot id: G3QJF3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:ATP6V1E2
gene id: 9595:ATP6V1E2
uniprot id: G3R7D0
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9595:LOC101127473
gene id: 9595:LOC101127473
uniprot id: G3RYZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MAN2A2
gene id: 9595:MAN2A2
uniprot id: G3QYR7
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9595:ARMC1
gene id: 9595:ARMC1
uniprot id: G3RPG2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9595:TNS2
gene id: 9595:TNS2
uniprot id: G3RFX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9595:MCCC2
gene id: 9595:MCCC2
uniprot id: A0A2I2ZT81
names: Similarity
messages: Belongs to the AccD/PCCB family.

9595:HTRA2
gene id: 9595:HTRA2
uniprot id: G3QU02
names: Similarity
messages: Belongs to the peptidase S1C family.

9595:KCNK10
gene id: 9595:KCNK10
uniprot id: A0A2I2ZIQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:GCK
gene id: 9595:GCK
uniprot id: A0A2I2ZDN4
names: Similarity
messages: Belongs to the hexokinase family.

9595:CASP5
gene id: 9595:CASP5
uniprot id: G3RI80
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:SPIN1
gene id: 9595:SPIN1
uniprot id: G3QXB0
names: Similarity
messages: Belongs to the SPIN/STSY family.

9595:IL36G
gene id: 9595:IL36G
uniprot id: G3RIS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9595:PDS5A
gene id: 9595:PDS5A
uniprot id: G3QWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDS5 family.
messages: Nucleus

9595:GABRB3
gene id: 9595:GABRB3
uniprot id: A0A2I2YX51
uniprot id: G3R6H5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:HAPSTR1
gene id: 9595:HAPSTR1
uniprot id: G3R5A4
names: Subcellular Location Annotation
messages: Nucleus

9595:STAR
gene id: 9595:STAR
uniprot id: G3QSM4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9595:SH3BP4
gene id: 9595:SH3BP4
uniprot id: G3RCE8
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9595:MPP7
gene id: 9595:MPP7
uniprot id: G3RT21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9595:MYO16
gene id: 9595:MYO16
uniprot id: G3RLK0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:GNAT2
gene id: 9595:GNAT2
uniprot id: G3RBX2
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9595:HRH2
gene id: 9595:HRH2
uniprot id: A0A2I2Y6Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PRKCH
gene id: 9595:PRKCH
uniprot id: G3QZ70
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9595:ARAP2
gene id: 9595:ARAP2
uniprot id: G3RS92
names: Subcellular Location Annotation
messages: Cytoplasm

9595:LOC101131222
gene id: 9595:LOC101131222
uniprot id: A0A2I2YR16
uniprot id: G3QH59
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9595:BECN2
gene id: 9595:BECN2
uniprot id: G3QYP8
names: Similarity
messages: Belongs to the beclin family.

9595:HPDL
gene id: 9595:HPDL
uniprot id: G3QL76
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9595:BYSL
gene id: 9595:BYSL
uniprot id: G3SFZ0
names: Similarity
messages: Belongs to the bystin family.

9595:PAF1
gene id: 9595:PAF1
uniprot id: A0A2I2Z5M9
names: Similarity
messages: Belongs to the PAF1 family.

9595:FOXP4
gene id: 9595:FOXP4
uniprot id: G3RJT8
names: Subcellular Location Annotation
messages: Nucleus

9595:DIS3
gene id: 9595:DIS3
uniprot id: A0A2I2Y578
uniprot id: G3QUT3
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9595:MRPS27
gene id: 9595:MRPS27
uniprot id: G3R553
names: Subcellular Location Annotation
messages: Mitochondrion

9595:TXLNB
gene id: 9595:TXLNB
uniprot id: G3QLE7
names: Similarity
messages: Belongs to the taxilin family.

9595:LOC101123911
gene id: 9595:LOC101123911
uniprot id: G3RNK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:DHX8
gene id: 9595:DHX8
uniprot id: G3SFV7
names: Subcellular Location Annotation
messages: Nucleus

9595:CNKSR2
gene id: 9595:CNKSR2
uniprot id: A0A2I2YLC8
uniprot id: A0A2I2Z1K2
names: Similarity
messages: Belongs to the CNKSR family.

9595:NGRN
gene id: 9595:NGRN
uniprot id: G3RT32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9595:GRIA2
gene id: 9595:GRIA2
uniprot id: G3RAA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9595:SPI1
gene id: 9595:SPI1
uniprot id: G3QUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:IQSEC3
gene id: 9595:IQSEC3
uniprot id: G3S130
names: Similarity
messages: Belongs to the BRAG family.

9595:GATAD1
gene id: 9595:GATAD1
uniprot id: G3SJQ6
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101142284
gene id: 9595:LOC101142284
uniprot id: G3R2J7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:RPS6KA1
gene id: 9595:RPS6KA1
uniprot id: A0A2I2ZKI3
uniprot id: G3QKB5
uniprot id: G3SI99
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9595:NUMBL
gene id: 9595:NUMBL
uniprot id: G3RTX6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a role in the process of neurogenesis.

9595:ACKR3
gene id: 9595:ACKR3
uniprot id: G3QNR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:AVPI1
gene id: 9595:AVPI1
uniprot id: G3RMY3
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9595:HPS3
gene id: 9595:HPS3
uniprot id: G3S9Z3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9595:FGF5
gene id: 9595:FGF5
uniprot id: A0A2I2YYH7
uniprot id: G3QKB9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:CCR6
gene id: 9595:CCR6
uniprot id: A0A2I2YD51
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:DARS1
gene id: 9595:DARS1
uniprot id: A0A2I2Y6L3
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9595:TRAPPC3L
gene id: 9595:TRAPPC3L
uniprot id: A0A2I2Y6L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9595:LIG4
gene id: 9595:LIG4
uniprot id: G3S2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9595:POLR2L
gene id: 9595:POLR2L
uniprot id: G3R5H2
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

9595:GPAM
gene id: 9595:GPAM
uniprot id: G3RLC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9595:NNMT
gene id: 9595:NNMT
uniprot id: G3QME2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9595:EIF3G
gene id: 9595:EIF3G
uniprot id: G3QRQ9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9595:BCOR
gene id: 9595:BCOR
uniprot id: G3RG00
names: Similarity
messages: Belongs to the BCOR family.

9595:TMEM263
gene id: 9595:TMEM263
uniprot id: G3S3B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9595:BLOC1S5
gene id: 9595:BLOC1S5
uniprot id: A0A2I2YA28
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

9595:CALCR
gene id: 9595:CALCR
uniprot id: G3SDU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

9595:APPL2
gene id: 9595:APPL2
uniprot id: G3RBH7
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9595:HCRTR1
gene id: 9595:HCRTR1
uniprot id: G3RIJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TPD52L2
gene id: 9595:TPD52L2
uniprot id: A0A2I2YE13
uniprot id: A0A2I2ZJD9
uniprot id: A0A2I2ZKW7
uniprot id: G3QE72
names: Similarity
messages: Belongs to the TPD52 family.

9595:MED29
gene id: 9595:MED29
uniprot id: G3QHI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9595:LOC101128133
gene id: 9595:LOC101128133
uniprot id: A4H211
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2.
messages: Membrane
messages: Monomer. Interacts with CCR2 (via extracellular N-terminal region); this interaction may preferentially require specific tyrosine sulfation on CCR2.
messages: Secreted

9595:GRM1
gene id: 9595:GRM1
uniprot id: G3RGA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9595:LOC101144264
gene id: 9595:LOC101144264
uniprot id: G3R156
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:SYT15
gene id: 9595:SYT15
uniprot id: G3RX04
uniprot id: G3RZG6
names: Similarity
messages: Belongs to the synaptotagmin family.

9595:EEF1G
gene id: 9595:EEF1G
uniprot id: G3S0A9
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9595:COX5A
gene id: 9595:COX5A
uniprot id: A0A2I2YSZ5
uniprot id: B0VYX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with AFG1L (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9595:UTP6
gene id: 9595:UTP6
uniprot id: G3RCL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

9595:FGF16
gene id: 9595:FGF16
uniprot id: G3QIJ1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:METTL4
gene id: 9595:METTL4
uniprot id: G3QF59
names: Similarity
messages: Belongs to the MT-A70-like family.

9595:LCN1
gene id: 9595:LCN1
uniprot id: G3QM49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9595:PIERCE2
gene id: 9595:PIERCE2
uniprot id: A0A2I2YXM8
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9595:PAIP2B
gene id: 9595:PAIP2B
uniprot id: A0A2I2YN04
names: Similarity
messages: Belongs to the PAIP2 family.

9595:INHBC
gene id: 9595:INHBC
uniprot id: G3S8C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9595:PSENEN
gene id: 9595:PSENEN
uniprot id: G3RKY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9595:TIMM21
gene id: 9595:TIMM21
uniprot id: G3RIN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9595:KCNN3
gene id: 9595:KCNN3
uniprot id: A0A2I2ZL41
uniprot id: G3S7U0
names: Subcellular Location Annotation
messages: Membrane

9595:PARD6G
gene id: 9595:PARD6G
uniprot id: A0A2I2YCP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9595:FAM210A
gene id: 9595:FAM210A
uniprot id: G3QK48
names: Similarity
messages: Belongs to the FAM210 family.

9595:TRIM67
gene id: 9595:TRIM67
uniprot id: G3QLM3
names: Subcellular Location Annotation
messages: cytoskeleton

9595:CNOT10
gene id: 9595:CNOT10
uniprot id: A0A2I2YIL4
uniprot id: G3QD61
uniprot id: G3RPD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9595:GASK1A
gene id: 9595:GASK1A
uniprot id: G3QEK9
names: Similarity
messages: Belongs to the GASK family.

9595:EEF1D
gene id: 9595:EEF1D
uniprot id: A0A2I2Y439
uniprot id: A0A2I2YE77
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

9595:AGPAT2
gene id: 9595:AGPAT2
uniprot id: G3S699
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9595:SNRNP27
gene id: 9595:SNRNP27
uniprot id: A0A2I2Y8F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9595:METTL1
gene id: 9595:METTL1
uniprot id: A0A2I2YEB8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with WDR4.
messages: Nucleus
messages: Phosphorylation at Ser-52 inactivates its catalytic activity but does not affect the interaction with WDR4.

9595:TRMT6
gene id: 9595:TRMT6
uniprot id: G3QZT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9595:CAPZA3
gene id: 9595:CAPZA3
uniprot id: G3RLE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9595:TMED6
gene id: 9595:TMED6
uniprot id: G3QXM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:SYN3
gene id: 9595:SYN3
uniprot id: A0A2I2Y534
names: Similarity
messages: Belongs to the synapsin family.

9595:BRPF3
gene id: 9595:BRPF3
uniprot id: G3RC63
names: Subcellular Location Annotation
messages: Nucleus

9595:DNAJC25
gene id: 9595:DNAJC25
uniprot id: G3R9K7
names: Similarity
messages: Belongs to the DNAJC25 family.

9595:AK5
gene id: 9595:AK5
uniprot id: G3REZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9595:LOC101131991
gene id: 9595:LOC101131991
uniprot id: G3RCZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9595:TTC4
gene id: 9595:TTC4
uniprot id: G3QRP6
names: Similarity
messages: Belongs to the TTC4 family.

9595:CXCL9
gene id: 9595:CXCL9
uniprot id: G3QPL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:RELL1
gene id: 9595:RELL1
uniprot id: G3RG41
names: Similarity
messages: Belongs to the RELT family.

9595:DNM3
gene id: 9595:DNM3
uniprot id: A0A2I2YL61
uniprot id: G3R025
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9595:FGD3
gene id: 9595:FGD3
uniprot id: A0A2I2YN64
uniprot id: G3R0M3
names: Subcellular Location Annotation
messages: cytoskeleton

9595:MYF5
gene id: 9595:MYF5
uniprot id: G3QNZ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9595:SRPX2
gene id: 9595:SRPX2
uniprot id: G3R3E3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MANEAL
gene id: 9595:MANEAL
uniprot id: A0A2I2YYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:TALDO1
gene id: 9595:TALDO1
uniprot id: G3R5A9
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

9595:ALX4
gene id: 9595:ALX4
uniprot id: G3RED1
names: Subcellular Location Annotation
messages: Nucleus

9595:TMTC4
gene id: 9595:TMTC4
uniprot id: G3R9Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9595:RAB9B
gene id: 9595:RAB9B
uniprot id: G3R246
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9595:KRT3
gene id: 9595:KRT3
uniprot id: G3QMP4
names: Similarity
messages: Belongs to the intermediate filament family.

9595:QSOX1
gene id: 9595:QSOX1
uniprot id: A0A2I2ZYR1
uniprot id: G3R3B5
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

9595:PRM2
gene id: 9595:PRM2
uniprot id: G3QEH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protamine P2 family.
messages: Interacts with TDRP.
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

9595:APOC2
gene id: 9595:APOC2
uniprot id: A0A2I2Z3W8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
messages: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
messages: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
messages: Secreted

9595:CCDC167
gene id: 9595:CCDC167
uniprot id: G3QSA7
names: Subcellular Location Annotation
messages: Membrane

9595:UIMC1
gene id: 9595:UIMC1
uniprot id: G3RLL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

9595:TSPAN15
gene id: 9595:TSPAN15
uniprot id: G3QXQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:CSK
gene id: 9595:CSK
uniprot id: G3R6C9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9595:FAM20B
gene id: 9595:FAM20B
uniprot id: G3QJ63
names: Similarity
messages: Belongs to the FAM20 family.

9595:PLPPR1
gene id: 9595:PLPPR1
uniprot id: G3RUV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9595:RPL28
gene id: 9595:RPL28
uniprot id: A0A2I2YY03
uniprot id: G3SBX2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

9595:TM4SF18
gene id: 9595:TM4SF18
uniprot id: G3QIU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9595:LPCAT1
gene id: 9595:LPCAT1
uniprot id: G3RHY4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9595:SEC13
gene id: 9595:SEC13
uniprot id: G3R3T3
uniprot id: G3SAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane

9595:PTGES3
gene id: 9595:PTGES3
uniprot id: A0A2I2ZAY2
uniprot id: A0A2I2ZT10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9595:BCLAF1
gene id: 9595:BCLAF1
uniprot id: G3QHH1
uniprot id: G3SDE6
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9595:SLC2A6
gene id: 9595:SLC2A6
uniprot id: G3RA13
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9595:LOC101131791
gene id: 9595:LOC101131791
uniprot id: G3RL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9595:PRR23C
gene id: 9595:PRR23C
uniprot id: A0A2I2YPA4
names: Similarity
messages: Belongs to the PRR23 family.

9595:MMP12
gene id: 9595:MMP12
uniprot id: G3RMX3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:PIK3C2A
gene id: 9595:PIK3C2A
uniprot id: G3RRS8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9595:LOC101128279
gene id: 9595:LOC101128279
uniprot id: A0A2I2ZGA3
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:EDA2R
gene id: 9595:EDA2R
uniprot id: G3SBP4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TCF7L1
gene id: 9595:TCF7L1
uniprot id: G3QZP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9595:AFP
gene id: 9595:AFP
uniprot id: G3QZW5
names: Subcellular Location Annotation
messages: Secreted

9595:RNF7
gene id: 9595:RNF7
uniprot id: G3QHH4
names: Similarity
messages: Belongs to the RING-box family.

9595:APMAP
gene id: 9595:APMAP
uniprot id: G3QG13
names: Similarity
messages: Belongs to the strictosidine synthase family.

9595:EFNA5
gene id: 9595:EFNA5
uniprot id: G3QDP0
uniprot id: G3SHR8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SLC30A9
gene id: 9595:SLC30A9
uniprot id: G3QHK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

9595:PPP2R5D
gene id: 9595:PPP2R5D
uniprot id: G3QWE9
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9595:LOC101126269
gene id: 9595:LOC101126269
uniprot id: G3RN95
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:P4HA2
gene id: 9595:P4HA2
uniprot id: G3SJ87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9595:CHD9
gene id: 9595:CHD9
uniprot id: G3RS86
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9595:REXO2
gene id: 9595:REXO2
uniprot id: A0A2I2YJB0
uniprot id: G3S0H2
names: Similarity
messages: Belongs to the oligoribonuclease family.

9595:UBE4A
gene id: 9595:UBE4A
uniprot id: A0A2I2ZD19
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

9595:LOC101137052
gene id: 9595:LOC101137052
uniprot id: G3R8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:DEDD
gene id: 9595:DEDD
uniprot id: A0A2I2YKS2
names: Subcellular Location Annotation
messages: nucleolus

9595:ARPC3
gene id: 9595:ARPC3
uniprot id: A0A2I2Y8K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9595:SLC2A2
gene id: 9595:SLC2A2
uniprot id: G3SES5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9595:TNFRSF10C
gene id: 9595:TNFRSF10C
uniprot id: A0A2I2ZU78
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TIMM8B
gene id: 9595:TIMM8B
uniprot id: A0A2I2Z2U1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9595:SLC41A1
gene id: 9595:SLC41A1
uniprot id: G3RAG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9595:ZSCAN5B
gene id: 9595:ZSCAN5B
uniprot id: G3RDX7
names: Subcellular Location Annotation
messages: Nucleus

9595:NFRKB
gene id: 9595:NFRKB
uniprot id: G3RH61
names: Subcellular Location Annotation
messages: Nucleus

9595:IFI35
gene id: 9595:IFI35
uniprot id: G3R0I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9595:SLC2A11
gene id: 9595:SLC2A11
uniprot id: A0A2I2ZBH9
uniprot id: G3R8K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane

9595:CWF19L2
gene id: 9595:CWF19L2
uniprot id: G3QCV0
names: Similarity
messages: Belongs to the CWF19 family.

9595:RXFP4
gene id: 9595:RXFP4
uniprot id: G3SKU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:SLC17A8
gene id: 9595:SLC17A8
uniprot id: G3RKY2
names: Subcellular Location Annotation
messages: Membrane

9595:XRN1
gene id: 9595:XRN1
uniprot id: A0A2I2YLX7
uniprot id: G3QYF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9595:LYAR
gene id: 9595:LYAR
uniprot id: G3RB50
names: Subcellular Location Annotation
messages: Cytoplasm

9595:LOC101141136
gene id: 9595:LOC101141136
uniprot id: G3SCC9
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:SMU1
gene id: 9595:SMU1
uniprot id: G3RFS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9595:GBA2
gene id: 9595:GBA2
uniprot id: A0A2I2YRQ7
uniprot id: G3QWP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

9595:FAM162A
gene id: 9595:FAM162A
uniprot id: G3SB09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9595:ICOS
gene id: 9595:ICOS
uniprot id: G3RDY9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9595:FAM8A1
gene id: 9595:FAM8A1
uniprot id: G3S6H9
names: Subcellular Location Annotation
messages: Membrane

9595:SLC31A1
gene id: 9595:SLC31A1
uniprot id: A0A2I2ZNZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:LOC101152080
gene id: 9595:LOC101152080
uniprot id: A0A2I2ZQS3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:GABRG2
gene id: 9595:GABRG2
uniprot id: A0A2I2YBS2
uniprot id: G3R6I5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:AMZ2
gene id: 9595:AMZ2
uniprot id: A0A2I2YNT0
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9595:SCNN1B
gene id: 9595:SCNN1B
uniprot id: G3QGR0
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101134051
gene id: 9595:LOC101134051
uniprot id: A0A2I2ZN27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:GNG3
gene id: 9595:GNG3
uniprot id: G3QL06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9595:SAE1
gene id: 9595:SAE1
uniprot id: G3RBB9
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9595:KIAA1191
gene id: 9595:KIAA1191
uniprot id: G3SJC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9595:OSBPL3
gene id: 9595:OSBPL3
uniprot id: G3R4Q4
names: Similarity
messages: Belongs to the OSBP family.

9595:NUP107
gene id: 9595:NUP107
uniprot id: G3RA29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

9595:SLC18A3
gene id: 9595:SLC18A3
uniprot id: G3SKN2
names: Subcellular Location Annotation
messages: Membrane

9595:DIMT1
gene id: 9595:DIMT1
uniprot id: G3QIQ8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9595:GSTO1
gene id: 9595:GSTO1
uniprot id: A0A2I2YFL5
uniprot id: G3QQT9
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9595:SELP
gene id: 9595:SELP
uniprot id: G3QF58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:CHAC2
gene id: 9595:CHAC2
uniprot id: A0A2I2ZG85
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9595:GPR158
gene id: 9595:GPR158
uniprot id: G3RIM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:STK39
gene id: 9595:STK39
uniprot id: G3SH11
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9595:ITGA9
gene id: 9595:ITGA9
uniprot id: G3RB97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:LEF1
gene id: 9595:LEF1
uniprot id: A0A2I2Y353
uniprot id: A0A2I2ZGI1
uniprot id: G3S1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9595:AADAC
gene id: 9595:AADAC
uniprot id: G3QIK6
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9595:MRPL9
gene id: 9595:MRPL9
uniprot id: G3QHN7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

9595:RHPN1
gene id: 9595:RHPN1
uniprot id: G3RN00
names: Similarity
messages: Belongs to the RHPN family.

9595:RNF141
gene id: 9595:RNF141
uniprot id: G3QKU0
names: Function
messages: May be involved in spermatogenesis.

9595:TRMT1L
gene id: 9595:TRMT1L
uniprot id: G3R7Y9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

9595:GPRIN3
gene id: 9595:GPRIN3
uniprot id: A0A2I2Z279
names: Function
messages: May be involved in neurite outgrowth.

9595:GLS
gene id: 9595:GLS
uniprot id: G3QX94
uniprot id: G3SB67
names: Similarity
messages: Belongs to the glutaminase family.

9595:BID
gene id: 9595:BID
uniprot id: G3R4T6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:FABP7
gene id: 9595:FABP7
uniprot id: A0A2I2YNI9
uniprot id: G3S7I0
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:SDE2
gene id: 9595:SDE2
uniprot id: G3R309
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

9595:CAND2
gene id: 9595:CAND2
uniprot id: G3QFC2
names: Similarity
messages: Belongs to the CAND family.

9595:SLC9A8
gene id: 9595:SLC9A8
uniprot id: G3QHU1
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9595:MAF1
gene id: 9595:MAF1
uniprot id: G3QIW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

9595:LOC101126119
gene id: 9595:LOC101126119
uniprot id: G3QWI7
names: Similarity
messages: Belongs to the intermediate filament family.

9595:KCNJ13
gene id: 9595:KCNJ13
uniprot id: G3R0D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9595:WNT8A
gene id: 9595:WNT8A
uniprot id: G3QNT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:PDIK1L
gene id: 9595:PDIK1L
uniprot id: G3RVD5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:LSM4
gene id: 9595:LSM4
uniprot id: G3RAW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9595:CIT
gene id: 9595:CIT
uniprot id: A0A2I2YXF8
uniprot id: G3RBB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

9595:PLPBP
gene id: 9595:PLPBP
uniprot id: G3RAS4
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9595:CAPZB
gene id: 9595:CAPZB
uniprot id: A0A2I2Z2V7
uniprot id: G3RPD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton
messages: sarcomere

9595:CHSY1
gene id: 9595:CHSY1
uniprot id: G3R0R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9595:LCN2
gene id: 9595:LCN2
uniprot id: G3SEI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9595:LOC101137932
gene id: 9595:LOC101137932
uniprot id: G3QDX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9595:RPS28
gene id: 9595:RPS28
uniprot id: G3RU06
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

9595:CLDN1
gene id: 9595:CLDN1
uniprot id: G3RDP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:GC
gene id: 9595:GC
uniprot id: G3REP7
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9595:AURKA
gene id: 9595:AURKA
uniprot id: G3QW90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9595:CDH24
gene id: 9595:CDH24
uniprot id: A0A2I2Z4R1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:KRTCAP3
gene id: 9595:KRTCAP3
uniprot id: G3QFH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9595:TEX10
gene id: 9595:TEX10
uniprot id: G3QHL7
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9595:CACNG5
gene id: 9595:CACNG5
uniprot id: G3RZQ2
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

9595:YOD1
gene id: 9595:YOD1
uniprot id: A0A2I2YDR5
uniprot id: G3QU72
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9595:NSG1
gene id: 9595:NSG1
uniprot id: G3R690
names: Similarity
messages: Belongs to the NSG family.

9595:ST8SIA2
gene id: 9595:ST8SIA2
uniprot id: G3R9X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:TAF1B
gene id: 9595:TAF1B
uniprot id: G3QJP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

9595:HDAC10
gene id: 9595:HDAC10
uniprot id: A0A2I2ZGN8
uniprot id: A0A2I2ZMZ8
uniprot id: G3REU8
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

9595:SERPINB11
gene id: 9595:SERPINB11
uniprot id: A0A2I2ZTW5
names: Similarity
messages: Belongs to the serpin family.

9595:RCL1
gene id: 9595:RCL1
uniprot id: A0A2I2YDW0
uniprot id: G3RGD4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

9595:LAMA1
gene id: 9595:LAMA1
uniprot id: G3RYE2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9595:MMP15
gene id: 9595:MMP15
uniprot id: G3S700
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:MIS18A
gene id: 9595:MIS18A
uniprot id: G3QQ71
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9595:UVSSA
gene id: 9595:UVSSA
uniprot id: G3QQB0
names: Similarity
messages: Belongs to the UVSSA family.

9595:ALDH4A1
gene id: 9595:ALDH4A1
uniprot id: G3QS05
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:MRPL12
gene id: 9595:MRPL12
uniprot id: G3R1R2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9595:PFKFB2
gene id: 9595:PFKFB2
uniprot id: A0A2I2Y745
uniprot id: A0A2I2ZII5
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9595:AKR1B1
gene id: 9595:AKR1B1
uniprot id: G3R7U6
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9595:PPP1R1A
gene id: 9595:PPP1R1A
uniprot id: G3QZ87
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9595:ABRACL
gene id: 9595:ABRACL
uniprot id: G3R0S3
names: Similarity
messages: Belongs to the costars family.

9595:POLR1F
gene id: 9595:POLR1F
uniprot id: G3RU18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9595:SLC44A4
gene id: 9595:SLC44A4
uniprot id: G3R0T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9595:LAMTOR3
gene id: 9595:LAMTOR3
uniprot id: G3QFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9595:ARF6
gene id: 9595:ARF6
uniprot id: A0A2I2Z417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

9595:LOC101133649
gene id: 9595:LOC101133649
uniprot id: P61638
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9595:LOC101145420
gene id: 9595:LOC101145420
uniprot id: G3QEG5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:HSPA9
gene id: 9595:HSPA9
uniprot id: G3RE43
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9595:NKAIN2
gene id: 9595:NKAIN2
uniprot id: G3R2K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9595:ELOVL6
gene id: 9595:ELOVL6
uniprot id: G3QDA7
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9595:GALK1
gene id: 9595:GALK1
uniprot id: G3R272
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9595:MTTP
gene id: 9595:MTTP
uniprot id: G3QDV8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:IP6K3
gene id: 9595:IP6K3
uniprot id: G3RJJ9
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9595:UBA52
gene id: 9595:UBA52
uniprot id: A0A2I2YPT0
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

9595:GRM6
gene id: 9595:GRM6
uniprot id: G3R8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9595:LHX9
gene id: 9595:LHX9
uniprot id: A0A2I2Z1J5
names: Subcellular Location Annotation
messages: Nucleus

9595:PTK2
gene id: 9595:PTK2
uniprot id: G3S1C3
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9595:ERVW-1
gene id: 9595:ERVW-1
uniprot id: P61561
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.
messages: Cell membrane
messages: Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes (By similarity).
messages: Ortholog of the human HERV-W_7q21.2 envelope protein.
messages: Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as an inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R (By similarity).
messages: The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo (By similarity).
messages: The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein (By similarity).
messages: The cytoplasmic region is essential for the fusiogenic function.
messages: The genome contains a high percentage of proviral-like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit.
messages: The mature envelope protein (Env) consists of a trimer of SU-TM heterodimers attached probably by a labile interchain disulfide bond. Interacts with the C-type lectin CD209/DC-SIGN (By similarity).
messages: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May recognize and induce fusion through binding of SLC1A4 and SLC1A5 (By similarity).
messages: Virion

9595:ST6GALNAC4
gene id: 9595:ST6GALNAC4
uniprot id: G3RFF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:TNFAIP1
gene id: 9595:TNFAIP1
uniprot id: G3QPI7
names: Similarity
messages: Belongs to the BACURD family.

9595:GTF2A2
gene id: 9595:GTF2A2
uniprot id: G3RVY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9595:PDK4
gene id: 9595:PDK4
uniprot id: G3QJ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9595:SLC7A13
gene id: 9595:SLC7A13
uniprot id: G3QZK6
names: Subcellular Location Annotation
messages: Membrane

9595:ATP6V1E1
gene id: 9595:ATP6V1E1
uniprot id: G3RGC3
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9595:LOC101148069
gene id: 9595:LOC101148069
uniprot id: G3R255
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9595:FAS
gene id: 9595:FAS
uniprot id: G3S9B2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

9595:ITPA
gene id: 9595:ITPA
uniprot id: G3R067
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9595:NME7
gene id: 9595:NME7
uniprot id: A0A2I2YP06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9595:KDM4B
gene id: 9595:KDM4B
uniprot id: G3R2U2
uniprot id: G3RR88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9595:PLPPR5
gene id: 9595:PLPPR5
uniprot id: G3RQY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9595:ZNF24
gene id: 9595:ZNF24
uniprot id: A0A2I2Y5T7
names: Subcellular Location Annotation
messages: Nucleus

9595:CHST3
gene id: 9595:CHST3
uniprot id: A0A2I2ZJP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9595:TAF9B
gene id: 9595:TAF9B
uniprot id: G3QJ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9595:RAB3D
gene id: 9595:RAB3D
uniprot id: A0A2I2ZMK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9595:TMEM255A
gene id: 9595:TMEM255A
uniprot id: A0A2I2ZM24
uniprot id: G3R472
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9595:UBE2E2
gene id: 9595:UBE2E2
uniprot id: A0A2I2ZJ41
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:TM2D3
gene id: 9595:TM2D3
uniprot id: A0A2I2YIC7
uniprot id: G3R7H2
names: Subcellular Location Annotation
messages: Membrane

9595:GTF2A1
gene id: 9595:GTF2A1
uniprot id: A0A2I2YC53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9595:PRMT7
gene id: 9595:PRMT7
uniprot id: G3QGT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

9595:IFNAR1
gene id: 9595:IFNAR1
uniprot id: A0A2I2YH23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9595:EMC6
gene id: 9595:EMC6
uniprot id: G3R352
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:DCST1
gene id: 9595:DCST1
uniprot id: G3RDD3
names: Subcellular Location Annotation
messages: Membrane

9595:DERL3
gene id: 9595:DERL3
uniprot id: G3QEY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9595:KIF5B
gene id: 9595:KIF5B
uniprot id: G3RC75
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:PRR5L
gene id: 9595:PRR5L
uniprot id: G3R0M0
names: Similarity
messages: Belongs to the PROTOR family.

9595:HGF
gene id: 9595:HGF
uniprot id: G3QLL7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9595:FGF23
gene id: 9595:FGF23
uniprot id: G3QKE3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:SH3PXD2A
gene id: 9595:SH3PXD2A
uniprot id: A0A2I2YW67
uniprot id: A0A2I2ZS83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm

9595:ACTN4
gene id: 9595:ACTN4
uniprot id: A0A2I2YSG9
uniprot id: A0A2I2Z0A7
uniprot id: A0A2I2Z718
names: Similarity
messages: Belongs to the alpha-actinin family.

9595:B3GNT9
gene id: 9595:B3GNT9
uniprot id: A0A2I2ZUA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:BTN1A1
gene id: 9595:BTN1A1
uniprot id: G3SBE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9595:IRF3
gene id: 9595:IRF3
uniprot id: A0A2I2Z8H4
uniprot id: A0A2I2ZG68
uniprot id: G3S7V6
names: Subcellular Location Annotation
messages: Nucleus

9595:PRKX
gene id: 9595:PRKX
uniprot id: A0A2I2YLR9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:NKX2-5
gene id: 9595:NKX2-5
uniprot id: G3RLM6
names: Subcellular Location Annotation
messages: Nucleus

9595:RPRD1A
gene id: 9595:RPRD1A
uniprot id: A0A2I2YFV1
uniprot id: G3QWP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

9595:FLNA
gene id: 9595:FLNA
uniprot id: A0A2I2YQV4
uniprot id: G3QNL9
names: Similarity
messages: Belongs to the filamin family.

9595:CDK14
gene id: 9595:CDK14
uniprot id: A0A2I2ZU98
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:AGXT
gene id: 9595:AGXT
uniprot id: G3RFG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisome

9595:LOC101151369
gene id: 9595:LOC101151369
uniprot id: G3RAB3
names: Function
names: Subcellular Location Annotation
messages: Anchoring filament protein which is a component of the basement membrane zone.
messages: basement membrane

9595:LOC101153072
gene id: 9595:LOC101153072
uniprot id: G3R2D5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:ACE2
gene id: 9595:ACE2
uniprot id: G3QWX4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9595:GIP
gene id: 9595:GIP
uniprot id: G3SCT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

9595:AKAP3
gene id: 9595:AKAP3
uniprot id: G3RED8
names: Similarity
messages: Belongs to the AKAP110 family.

9595:NPNT
gene id: 9595:NPNT
uniprot id: A0A2I2ZRN1
uniprot id: G3RCY8
uniprot id: G3S615
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:JAG1
gene id: 9595:JAG1
uniprot id: G3RXX3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9595:SLC24A3
gene id: 9595:SLC24A3
uniprot id: G3QP00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9595:ADAM33
gene id: 9595:ADAM33
uniprot id: G3RLB2
uniprot id: G3RSF1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC109025909
gene id: 9595:LOC109025909
uniprot id: G3RQE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9595:SLC25A22
gene id: 9595:SLC25A22
uniprot id: G3R5C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:TATDN2
gene id: 9595:TATDN2
uniprot id: G3R3S1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9595:GALP
gene id: 9595:GALP
uniprot id: G3RDW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
messages: Secreted

9595:GNPDA2
gene id: 9595:GNPDA2
uniprot id: G3RIE4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9595:C3
gene id: 9595:C3
uniprot id: G3SA61
names: Function
names: Subcellular Location Annotation
messages: Acts as a chemoattractant for neutrophils in chronic inflammation.
messages: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
messages: Secreted

9595:VNN2
gene id: 9595:VNN2
uniprot id: G3R492
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9595:KIF14
gene id: 9595:KIF14
uniprot id: G3RD87
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:GLRA1
gene id: 9595:GLRA1
uniprot id: G3REP2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

9595:UBAC2
gene id: 9595:UBAC2
uniprot id: G3SKK0
names: Subcellular Location Annotation
messages: Membrane

9595:CDK1
gene id: 9595:CDK1
uniprot id: G3RBW7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:ZFYVE27
gene id: 9595:ZFYVE27
uniprot id: A0A2I2ZRA3
uniprot id: G3SEV8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9595:FURIN
gene id: 9595:FURIN
uniprot id: G3QYP4
names: Similarity
messages: Belongs to the peptidase S8 family.

9595:IER5
gene id: 9595:IER5
uniprot id: G3RAR3
names: Similarity
messages: Belongs to the IER family.

9595:SLC16A12
gene id: 9595:SLC16A12
uniprot id: G3QN08
names: Subcellular Location Annotation
messages: Membrane

9595:AMBN
gene id: 9595:AMBN
uniprot id: G3RCU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

9595:PF4V1
gene id: 9595:PF4V1
uniprot id: G3SA05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:SNAPIN
gene id: 9595:SNAPIN
uniprot id: G3QHF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9595:GJD3
gene id: 9595:GJD3
uniprot id: G3QKT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:BOLA1
gene id: 9595:BOLA1
uniprot id: G3QKD2
names: Similarity
messages: Belongs to the BolA/IbaG family.

9595:IL1R1
gene id: 9595:IL1R1
uniprot id: G3QLD8
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9595:SETD7
gene id: 9595:SETD7
uniprot id: G3R7Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9595:EMP2
gene id: 9595:EMP2
uniprot id: A0A2I2ZUU0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9595:TXNRD2
gene id: 9595:TXNRD2
uniprot id: A0A2I2ZNN4
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

9595:TUSC3
gene id: 9595:TUSC3
uniprot id: A0A2I2Y386
uniprot id: G3RER4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:THRA
gene id: 9595:THRA
uniprot id: G3R2I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:DRC7
gene id: 9595:DRC7
uniprot id: G3QZG8
uniprot id: G3SHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

9595:HDDC2
gene id: 9595:HDDC2
uniprot id: G3SI01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

9595:LCE1B
gene id: 9595:LCE1B
uniprot id: G3S2H5
names: Similarity
messages: Belongs to the LCE family.

9595:TPH2
gene id: 9595:TPH2
uniprot id: G3RB08
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9595:LOC101133708
gene id: 9595:LOC101133708
uniprot id: A0A2I2ZXD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:INPP4B
gene id: 9595:INPP4B
uniprot id: G3S6A4
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9595:MRPL37
gene id: 9595:MRPL37
uniprot id: G3R4P7
names: Subcellular Location Annotation
messages: Mitochondrion

9595:HAUS1
gene id: 9595:HAUS1
uniprot id: A0A2I2YSL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9595:LAMP5
gene id: 9595:LAMP5
uniprot id: G3RC35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Membrane

9595:FAM166B
gene id: 9595:FAM166B
uniprot id: G3R0X9
names: Similarity
messages: Belongs to the CIMIP2 family.

9595:DDX56
gene id: 9595:DDX56
uniprot id: G3R8N1
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9595:CEP44
gene id: 9595:CEP44
uniprot id: A0A2I2YC76
uniprot id: G3SDT4
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9595:SLC16A7
gene id: 9595:SLC16A7
uniprot id: G3SEK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9595:PDZK1IP1
gene id: 9595:PDZK1IP1
uniprot id: G3R7X9
names: Subcellular Location Annotation
messages: Membrane

9595:SAA4
gene id: 9595:SAA4
uniprot id: G3RZ43
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9595:FHIP2A
gene id: 9595:FHIP2A
uniprot id: A0A2I2Z5Z5
uniprot id: G3RZX4
names: Similarity
messages: Belongs to the FHIP family.

9595:GJD4
gene id: 9595:GJD4
uniprot id: G3QST2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:DAPK3
gene id: 9595:DAPK3
uniprot id: G3QHZ8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:EMC4
gene id: 9595:EMC4
uniprot id: A0A2I2ZU21
uniprot id: G3R5R9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:NAGPA
gene id: 9595:NAGPA
uniprot id: G3QQ81
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:XAGE5
gene id: 9595:XAGE5
uniprot id: G3QWF7
names: Similarity
messages: Belongs to the GAGE family.

9595:TFE3
gene id: 9595:TFE3
uniprot id: A0A2I2YS93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9595:NDP
gene id: 9595:NDP
uniprot id: G3RCG7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:PAGE1
gene id: 9595:PAGE1
uniprot id: G3QY22
names: Similarity
messages: Belongs to the GAGE family.

9595:PHAX
gene id: 9595:PHAX
uniprot id: G3RDD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

9595:TUBB1
gene id: 9595:TUBB1
uniprot id: G3RKF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9595:UGGT2
gene id: 9595:UGGT2
uniprot id: G3R5H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9595:ANXA13
gene id: 9595:ANXA13
uniprot id: G3QYM5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9595:S100A10
gene id: 9595:S100A10
uniprot id: A0A2I2ZWR8
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9595:SNAPC3
gene id: 9595:SNAPC3
uniprot id: G3QV46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

9595:EIPR1
gene id: 9595:EIPR1
uniprot id: A0A2I2YRZ5
uniprot id: G3RBH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

9595:RETNLB
gene id: 9595:RETNLB
uniprot id: G3R311
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9595:GSTCD
gene id: 9595:GSTCD
uniprot id: A0A2I2ZUI1
names: Similarity
messages: Belongs to the GSTCD family.

9595:MRM1
gene id: 9595:MRM1
uniprot id: G3SHA1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

9595:ASTL
gene id: 9595:ASTL
uniprot id: G3R9B1
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CFAP157
gene id: 9595:CFAP157
uniprot id: G3SG76
names: Similarity
messages: Belongs to the CFAP157 family.

9595:DLX5
gene id: 9595:DLX5
uniprot id: G3QP29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9595:TLE3
gene id: 9595:TLE3
uniprot id: G3SBS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9595:SLC5A12
gene id: 9595:SLC5A12
uniprot id: G3R1P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9595:OIP5
gene id: 9595:OIP5
uniprot id: G3QDK2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9595:KATNAL1
gene id: 9595:KATNAL1
uniprot id: G3S5S1
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9595:KIF4A
gene id: 9595:KIF4A
uniprot id: G3S0T3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:ERBB4
gene id: 9595:ERBB4
uniprot id: A0A2I2Z667
uniprot id: G3REI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9595:CENPM
gene id: 9595:CENPM
uniprot id: A0A2I2ZDJ6
names: Subcellular Location Annotation
messages: Nucleus

9595:FAM13A
gene id: 9595:FAM13A
uniprot id: A0A2I2YCU7
uniprot id: A0A2I2Z1M0
uniprot id: A0A2I2ZIL9
names: Similarity
messages: Belongs to the FAM13 family.

9595:SLC13A5
gene id: 9595:SLC13A5
uniprot id: G3QDD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9595:NMNAT3
gene id: 9595:NMNAT3
uniprot id: G3RQH0
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9595:MMD2
gene id: 9595:MMD2
uniprot id: G3SEX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:COG3
gene id: 9595:COG3
uniprot id: G3QT79
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9595:CNOT9
gene id: 9595:CNOT9
uniprot id: A0A2I2Y9V2
uniprot id: A0A2I2ZFB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9595:LOC101142657
gene id: 9595:LOC101142657
uniprot id: A0A2I2Y5W8
uniprot id: G3S085
names: Similarity
messages: Belongs to the filamin family.

9595:ACTN1
gene id: 9595:ACTN1
uniprot id: A0A2I2ZUB0
uniprot id: G3RK88
uniprot id: G3S5U4
names: Similarity
messages: Belongs to the alpha-actinin family.

9595:SLC7A8
gene id: 9595:SLC7A8
uniprot id: G3QWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9595:TULP3
gene id: 9595:TULP3
uniprot id: A0A2I2YNT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9595:TMEM231
gene id: 9595:TMEM231
uniprot id: A0A2I2ZLG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

9595:TUBB
gene id: 9595:TUBB
uniprot id: G3SB76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9595:HMGA2
gene id: 9595:HMGA2
uniprot id: A0A2I2YMA3
uniprot id: A0A2I2ZE73
uniprot id: A0A2I2ZTF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9595:USP2
gene id: 9595:USP2
uniprot id: G3QQW0
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:CCT2
gene id: 9595:CCT2
uniprot id: A0A2I2ZL99
uniprot id: G3QTT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9595:ZHX1
gene id: 9595:ZHX1
uniprot id: A1YF22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor.
messages: Belongs to the ZHX family.
messages: Forms homodimers. Also forms heterodimers with ZHX3 which is a prerequisite for repressor activity and with ZHX2. Interacts with NFYA. Interacts with ATF7IP (By similarity).
messages: Nucleus

9595:KCNK6
gene id: 9595:KCNK6
uniprot id: G3R3G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:CPO
gene id: 9595:CPO
uniprot id: G3RIY9
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:CSTPP1
gene id: 9595:CSTPP1
uniprot id: A0A2I2ZBY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: cytoskeleton

9595:DLAT
gene id: 9595:DLAT
uniprot id: G3QJ95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9595:MPV17
gene id: 9595:MPV17
uniprot id: G3SDX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9595:GATA3
gene id: 9595:GATA3
uniprot id: G3QTK0
names: Subcellular Location Annotation
messages: Nucleus

9595:NKX2-2
gene id: 9595:NKX2-2
uniprot id: G3QYG3
names: Subcellular Location Annotation
messages: Nucleus

9595:FABP3
gene id: 9595:FABP3
uniprot id: G3RET1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:LIPE
gene id: 9595:LIPE
uniprot id: G3RPT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Lipid droplet
messages: caveola
messages: cytosol

9595:STPG4
gene id: 9595:STPG4
uniprot id: G3QJ99
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:SSTR3
gene id: 9595:SSTR3
uniprot id: G3QFM1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:ANXA5
gene id: 9595:ANXA5
uniprot id: G3RKK8
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9595:PLA2G5
gene id: 9595:PLA2G5
uniprot id: G3QVJ8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9595:THBS2
gene id: 9595:THBS2
uniprot id: G3QK81
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:DDX31
gene id: 9595:DDX31
uniprot id: G3QZ32
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9595:CIAPIN1
gene id: 9595:CIAPIN1
uniprot id: G3S917
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9595:DBX2
gene id: 9595:DBX2
uniprot id: G3QPS0
names: Subcellular Location Annotation
messages: Nucleus

9595:PMF1
gene id: 9595:PMF1
uniprot id: G3R5R0
uniprot id: G3RSF3
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

9595:KMT2A
gene id: 9595:KMT2A
uniprot id: G3S2F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
messages: Nucleus

9595:GSG1
gene id: 9595:GSG1
uniprot id: G3QZQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9595:GNAO1
gene id: 9595:GNAO1
uniprot id: A0A2I2YU68
uniprot id: G3QIY9
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9595:LOC101150279
gene id: 9595:LOC101150279
uniprot id: A0A2I2ZY13
uniprot id: G3SDI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
messages: Involved in the presentation of foreign antigens to the immune system.

9595:HOXC11
gene id: 9595:HOXC11
uniprot id: G3SBM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9595:CDC123
gene id: 9595:CDC123
uniprot id: A0A2I2YZN4
uniprot id: G3RXA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9595:HDAC1
gene id: 9595:HDAC1
uniprot id: G3R7V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9595:DSC1
gene id: 9595:DSC1
uniprot id: G3RCH6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9595:MITF
gene id: 9595:MITF
uniprot id: G3S312
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9595:NDUFA9
gene id: 9595:NDUFA9
uniprot id: Q0MQB3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Acetylated on lysine residues. BLOC1S1 is required for acetylation.
messages: Belongs to the complex I NDUFA9 subunit family.
messages: Binds 1 FAD per subunit.
messages: Complex I is composed of 45 different subunits (By similarity). This a component of the hydrophobic protein fraction (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with SLC2A4 (By similarity). Interacts with CLOCK (By similarity). Interacts with RAB5IF (By similarity).
messages: Mitochondrion matrix

9595:LRRC8B
gene id: 9595:LRRC8B
uniprot id: G3QTC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9595:CD68
gene id: 9595:CD68
uniprot id: A0A2I2YG68
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9595:TENT5A
gene id: 9595:TENT5A
uniprot id: G3QFV6
names: Similarity
messages: Belongs to the TENT family.

9595:PCOLCE
gene id: 9595:PCOLCE
uniprot id: G3R5A8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:LIPG
gene id: 9595:LIPG
uniprot id: G3QE94
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:IMPDH1
gene id: 9595:IMPDH1
uniprot id: G3QMZ1
uniprot id: G3RZ87
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9595:PTOV1
gene id: 9595:PTOV1
uniprot id: G3RM16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
messages: Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: May interact with CREBBP. Interacts with FLOT1.
messages: Nucleus
messages: perinuclear region

9595:HERC4
gene id: 9595:HERC4
uniprot id: A0A2I2YMU2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:EBF2
gene id: 9595:EBF2
uniprot id: G3QGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9595:EBNA1BP2
gene id: 9595:EBNA1BP2
uniprot id: G3R052
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

9595:STX18
gene id: 9595:STX18
uniprot id: G3R6A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9595:CXCR6
gene id: 9595:CXCR6
uniprot id: G3QQ28
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

9595:TMED1
gene id: 9595:TMED1
uniprot id: G3QT41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9595:SCPEP1
gene id: 9595:SCPEP1
uniprot id: G3RS33
names: Similarity
messages: Belongs to the peptidase S10 family.

9595:SLC6A19
gene id: 9595:SLC6A19
uniprot id: G3QX55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:CENPA
gene id: 9595:CENPA
uniprot id: A0A2I2Y1U4
uniprot id: G3SF93
names: Similarity
messages: Belongs to the histone H3 family.

9595:BCAP29
gene id: 9595:BCAP29
uniprot id: G3SAF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9595:ZSCAN1
gene id: 9595:ZSCAN1
uniprot id: G3RHN2
names: Subcellular Location Annotation
messages: Nucleus

9595:LIN54
gene id: 9595:LIN54
uniprot id: A0A2I2YFY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9595:DDX50
gene id: 9595:DDX50
uniprot id: G3RT42
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9595:SERPINB6
gene id: 9595:SERPINB6
uniprot id: A0A2I2Z2G9
uniprot id: G3R677
names: Similarity
messages: Belongs to the serpin family.

9595:MAPKAPK3
gene id: 9595:MAPKAPK3
uniprot id: G3RG39
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:CNNM1
gene id: 9595:CNNM1
uniprot id: G3QJB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9595:PLAC8L1
gene id: 9595:PLAC8L1
uniprot id: G3QYX5
names: Similarity
messages: Belongs to the cornifelin family.

9595:DAD1
gene id: 9595:DAD1
uniprot id: A0A2I2YH80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9595:PIWIL3
gene id: 9595:PIWIL3
uniprot id: G3RHJ8
names: Similarity
messages: Belongs to the argonaute family.

9595:MEP1B
gene id: 9595:MEP1B
uniprot id: G3SF75
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:RNF13
gene id: 9595:RNF13
uniprot id: G3QW07
names: Subcellular Location Annotation
messages: Membrane

9595:MED23
gene id: 9595:MED23
uniprot id: G3QFA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

9595:PKD2
gene id: 9595:PKD2
uniprot id: G3QLB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

9595:CDH20
gene id: 9595:CDH20
uniprot id: G3QVJ7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:CCL14
gene id: 9595:CCL14
uniprot id: G3SA76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:SLC30A6
gene id: 9595:SLC30A6
uniprot id: A0A2I2YNK1
uniprot id: A0A2I2YR01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9595:CNKSR3
gene id: 9595:CNKSR3
uniprot id: G3QFX6
names: Similarity
messages: Belongs to the CNKSR family.

9595:SEC22C
gene id: 9595:SEC22C
uniprot id: A0A2I2YM15
uniprot id: A0A2I2ZBL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9595:GPR15
gene id: 9595:GPR15
uniprot id: G3RCT5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:IFITM1
gene id: 9595:IFITM1
uniprot id: G3QLG9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:LDLRAD1
gene id: 9595:LDLRAD1
uniprot id: A0A2I2Z7G2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PPME1
gene id: 9595:PPME1
uniprot id: G3QDL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

9595:LOC109025290
gene id: 9595:LOC109025290
uniprot id: A0A2I2YPE0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9595:SNRPA1
gene id: 9595:SNRPA1
uniprot id: G3RZB2
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9595:EPHB6
gene id: 9595:EPHB6
uniprot id: G3RHU7
names: Subcellular Location Annotation
messages: Membrane

9595:UNG
gene id: 9595:UNG
uniprot id: G3RY62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Monomer. Interacts with FAM72A.
messages: Nucleus

9595:UBALD2
gene id: 9595:UBALD2
uniprot id: G3R841
names: Similarity
messages: Belongs to the UBALD family.

9595:SLC25A42
gene id: 9595:SLC25A42
uniprot id: G3QYJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:REEP6
gene id: 9595:REEP6
uniprot id: G3QWJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9595:TRNT1
gene id: 9595:TRNT1
uniprot id: G3RGZ9
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9595:MRPS9
gene id: 9595:MRPS9
uniprot id: G3QXN0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9595:AQP9
gene id: 9595:AQP9
uniprot id: G3R8Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9595:NEURL2
gene id: 9595:NEURL2
uniprot id: G3RIM8
names: Subcellular Location Annotation
messages: Cytoplasm

9595:HMOX2
gene id: 9595:HMOX2
uniprot id: G3QZI8
names: Similarity
messages: Belongs to the heme oxygenase family.

9595:SFTPD
gene id: 9595:SFTPD
uniprot id: G3R0R1
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

9595:SEC24C
gene id: 9595:SEC24C
uniprot id: G3QTL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9595:SKIC2
gene id: 9595:SKIC2
uniprot id: G3QIM4
names: Subcellular Location Annotation
messages: Cytoplasm

9595:LOC101133357
gene id: 9595:LOC101133357
uniprot id: G3QYX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MYO1H
gene id: 9595:MYO1H
uniprot id: G3RXN4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:IL17RA
gene id: 9595:IL17RA
uniprot id: G3RZP6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:DPYSL5
gene id: 9595:DPYSL5
uniprot id: A0A2I2Z098
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9595:PRPS1
gene id: 9595:PRPS1
uniprot id: G3R9N5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9595:NUBP2
gene id: 9595:NUBP2
uniprot id: G3QTT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9595:SLC30A8
gene id: 9595:SLC30A8
uniprot id: G3RJB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9595:NKAIN1
gene id: 9595:NKAIN1
uniprot id: G3RV40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9595:PDHX
gene id: 9595:PDHX
uniprot id: A0A2I2Z7A6
uniprot id: G3QFV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9595:SGSM3
gene id: 9595:SGSM3
uniprot id: G3RGQ0
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

9595:NDUFB9
gene id: 9595:NDUFB9
uniprot id: Q0MQE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:LOC101148834
gene id: 9595:LOC101148834
uniprot id: G3QEE4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9595:APH1A
gene id: 9595:APH1A
uniprot id: G3RLP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9595:DUSP4
gene id: 9595:DUSP4
uniprot id: G3QSY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9595:MARF1
gene id: 9595:MARF1
uniprot id: G3R0R4
names: Subcellular Location Annotation
messages: Peroxisome

9595:GGH
gene id: 9595:GGH
uniprot id: G3QXM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9595:CPSF4L
gene id: 9595:CPSF4L
uniprot id: G3SJG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9595:IL12B
gene id: 9595:IL12B
uniprot id: G3QP48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Secreted

9595:ADAM9
gene id: 9595:ADAM9
uniprot id: G3QTB8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:TMEM135
gene id: 9595:TMEM135
uniprot id: A0A2I2YAS2
uniprot id: G3QJE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane

9595:IGFBP5
gene id: 9595:IGFBP5
uniprot id: G3RZ84
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:EIF3L
gene id: 9595:EIF3L
uniprot id: A0A2I2ZBL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9595:LOC101136057
gene id: 9595:LOC101136057
uniprot id: G3S7Z1
names: Subcellular Location Annotation
messages: Membrane

9595:MYO1B
gene id: 9595:MYO1B
uniprot id: A0A2I2Y765
uniprot id: A0A2I2YRV5
uniprot id: G3QIS4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:RNF146
gene id: 9595:RNF146
uniprot id: G3R9N0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9595:MOCOS
gene id: 9595:MOCOS
uniprot id: G3R2H1
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

9595:LEP
gene id: 9595:LEP
uniprot id: G3QF76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

9595:HOXA5
gene id: 9595:HOXA5
uniprot id: G3QIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9595:TP53
gene id: 9595:TP53
uniprot id: G3R2U9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9595:VCP
gene id: 9595:VCP
uniprot id: G3QL07
names: Similarity
messages: Belongs to the AAA ATPase family.

9595:GPR137
gene id: 9595:GPR137
uniprot id: A0A2I2YZB0
uniprot id: G3R979
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9595:IFRD2
gene id: 9595:IFRD2
uniprot id: G3QVY0
names: Similarity
messages: Belongs to the IFRD family.

9595:MED13
gene id: 9595:MED13
uniprot id: G3R2F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:LOC101142869
gene id: 9595:LOC101142869
uniprot id: G3RQ76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:CAP2
gene id: 9595:CAP2
uniprot id: G3RJN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9595:OTUB2
gene id: 9595:OTUB2
uniprot id: G3QV24
names: Similarity
messages: Belongs to the peptidase C65 family.

9595:RPS26
gene id: 9595:RPS26
uniprot id: G3R7E3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9595:HTR1B
gene id: 9595:HTR1B
uniprot id: G3RV57
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

9595:KIZ
gene id: 9595:KIZ
uniprot id: G3RNL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

9595:LOC101152321
gene id: 9595:LOC101152321
uniprot id: G3RXT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:TNFRSF1A
gene id: 9595:TNFRSF1A
uniprot id: G3SG18
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:BPNT2
gene id: 9595:BPNT2
uniprot id: G3RPL5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9595:EWSR1
gene id: 9595:EWSR1
uniprot id: G3R945
uniprot id: G3RNC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9595:SMAD5
gene id: 9595:SMAD5
uniprot id: G3RTX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9595:LOC101127179
gene id: 9595:LOC101127179
uniprot id: G3RPS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MEF2C
gene id: 9595:MEF2C
uniprot id: G3QK42
uniprot id: G3RY38
names: Subcellular Location Annotation
messages: Nucleus

9595:C10H10orf53
gene id: 9595:C10H10orf53
uniprot id: A0A2I2Z7V0
uniprot id: G3RMH5
names: Similarity
messages: Belongs to the UPF0728 family.

9595:FXYD2
gene id: 9595:FXYD2
uniprot id: A0A2I2ZHY3
uniprot id: G3S4V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FXYD family.
messages: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
messages: Membrane
messages: Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

9595:CTSZ
gene id: 9595:CTSZ
uniprot id: G3RKE4
names: Similarity
messages: Belongs to the peptidase C1 family.

9595:SORCS1
gene id: 9595:SORCS1
uniprot id: A0A2I2Z2C3
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9595:ODC1
gene id: 9595:ODC1
uniprot id: G3QY86
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9595:GOT1L1
gene id: 9595:GOT1L1
uniprot id: G3RE96
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

9595:ROM1
gene id: 9595:ROM1
uniprot id: G3RCM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9595:RRP36
gene id: 9595:RRP36
uniprot id: G3QWG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

9595:LOC101125648
gene id: 9595:LOC101125648
uniprot id: G3RVH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ASB17
gene id: 9595:ASB17
uniprot id: G3QL23
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9595:AMT
gene id: 9595:AMT
uniprot id: G3RNZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9595:RAB19
gene id: 9595:RAB19
uniprot id: G3RYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

9595:ATAD2B
gene id: 9595:ATAD2B
uniprot id: G3QT86
names: Similarity
messages: Belongs to the AAA ATPase family.

9595:PYM1
gene id: 9595:PYM1
uniprot id: A0A2I2YZ99
uniprot id: A0A2I2ZTF3
names: Similarity
names: Subunit
messages: Belongs to the pym family.
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9595:ATP5IF1
gene id: 9595:ATP5IF1
uniprot id: G3QEV8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9595:SPTLC3
gene id: 9595:SPTLC3
uniprot id: G3RA20
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9595:SLC2A3
gene id: 9595:SLC2A3
uniprot id: A0A2I2ZMF8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9595:ATPAF2
gene id: 9595:ATPAF2
uniprot id: G3QE00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9595:LSM14A
gene id: 9595:LSM14A
uniprot id: G3QHB1
names: Similarity
messages: Belongs to the LSM14 family.

9595:IFI27L2
gene id: 9595:IFI27L2
uniprot id: G3QX46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9595:JPT2
gene id: 9595:JPT2
uniprot id: G3QTN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9595:SERINC2
gene id: 9595:SERINC2
uniprot id: G3QYU9
uniprot id: G3RMP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9595:GNMT
gene id: 9595:GNMT
uniprot id: G3RCK3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9595:LOC101144243
gene id: 9595:LOC101144243
uniprot id: G3RD37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9595:TRAM1L1
gene id: 9595:TRAM1L1
uniprot id: G3QD22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9595:KCNG4
gene id: 9595:KCNG4
uniprot id: G3QGS1
names: Subcellular Location Annotation
messages: Membrane

9595:PALS2
gene id: 9595:PALS2
uniprot id: G3QR22
names: Similarity
messages: Belongs to the MAGUK family.

9595:PF4
gene id: 9595:PF4
uniprot id: G3RHN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:HCN1
gene id: 9595:HCN1
uniprot id: G3QGQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9595:SURF4
gene id: 9595:SURF4
uniprot id: G3SD28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:TAS2R38
gene id: 9595:TAS2R38
uniprot id: A0A2K5TIZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

9595:SPG7
gene id: 9595:SPG7
uniprot id: G3RVG4
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9595:KRT8
gene id: 9595:KRT8
uniprot id: G3SEY3
names: Similarity
messages: Belongs to the intermediate filament family.

9595:H1-2
gene id: 9595:H1-2
uniprot id: G3QXG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9595:VAMP4
gene id: 9595:VAMP4
uniprot id: G3SIP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9595:SNX32
gene id: 9595:SNX32
uniprot id: G3R5F7
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9595:GMPR
gene id: 9595:GMPR
uniprot id: G3QNH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9595:FAM133B
gene id: 9595:FAM133B
uniprot id: A0A2I2ZXK8
names: Similarity
messages: Belongs to the FAM133 family.

9595:ARHGEF7
gene id: 9595:ARHGEF7
uniprot id: A0A2I2ZG12
names: Subcellular Location Annotation
messages: lamellipodium

9595:KCNC2
gene id: 9595:KCNC2
uniprot id: A0A2I2Z6X8
uniprot id: G3S3N7
names: Subcellular Location Annotation
messages: Membrane

9595:ABCG4
gene id: 9595:ABCG4
uniprot id: G3R9V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9595:LCA5L
gene id: 9595:LCA5L
uniprot id: G3RBH0
names: Similarity
messages: Belongs to the LCA5 family.

9595:SDAD1
gene id: 9595:SDAD1
uniprot id: G3QUA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9595:FAT4
gene id: 9595:FAT4
uniprot id: A0A2I2YI73
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SLC26A7
gene id: 9595:SLC26A7
uniprot id: G3SD21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9595:GALR1
gene id: 9595:GALR1
uniprot id: G3QG75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:MSR1
gene id: 9595:MSR1
uniprot id: A0A2I2YAH6
names: Subcellular Location Annotation
messages: Membrane

9595:DUSP13B
gene id: 9595:DUSP13B
uniprot id: A0A2I2ZMC6
uniprot id: G3R607
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9595:PYCR2
gene id: 9595:PYCR2
uniprot id: G3R1T4
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9595:PDCD5
gene id: 9595:PDCD5
uniprot id: A0A2I2YIR7
uniprot id: G3QTK5
names: Similarity
messages: Belongs to the PDCD5 family.

9595:FAM228A
gene id: 9595:FAM228A
uniprot id: A0A2I2ZA00
names: Similarity
messages: Belongs to the FAM228 family.

9595:SENP7
gene id: 9595:SENP7
uniprot id: A0A2I2ZMJ6
uniprot id: G3R3D9
names: Similarity
messages: Belongs to the peptidase C48 family.

9595:SLC16A2
gene id: 9595:SLC16A2
uniprot id: G3R214
names: Subcellular Location Annotation
messages: Membrane

9595:ZIC3
gene id: 9595:ZIC3
uniprot id: G3R8B2
uniprot id: G3RYT4
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9595:UBP1
gene id: 9595:UBP1
uniprot id: A0A2I2Z5G6
uniprot id: G3SED0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9595:KPNA5
gene id: 9595:KPNA5
uniprot id: G3R8B6
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9595:XRN2
gene id: 9595:XRN2
uniprot id: G3SD30
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9595:OPHN1
gene id: 9595:OPHN1
uniprot id: G3SKP4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynapse
messages: Presynapse
messages: dendrite

9595:LTB4R2
gene id: 9595:LTB4R2
uniprot id: A0A2I2YAB5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:TPM3
gene id: 9595:TPM3
uniprot id: A0A2I2ZRG1
uniprot id: G3QDY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9595:FAXC
gene id: 9595:FAXC
uniprot id: A0A2I2Z1P2
names: Similarity
messages: Belongs to the FAX family.

9595:IL19
gene id: 9595:IL19
uniprot id: G3S310
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9595:STK11IP
gene id: 9595:STK11IP
uniprot id: G3QRY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

9595:RBP7
gene id: 9595:RBP7
uniprot id: G3RS30
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:AMH
gene id: 9595:AMH
uniprot id: G3S0U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
messages: Secreted

9595:SLC39A4
gene id: 9595:SLC39A4
uniprot id: G3RJC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9595:NR1H2
gene id: 9595:NR1H2
uniprot id: G3QS62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:IFNK
gene id: 9595:IFNK
uniprot id: G3S4T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9595:GUCY1A1
gene id: 9595:GUCY1A1
uniprot id: G3R8H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9595:PPP2CB
gene id: 9595:PPP2CB
uniprot id: G3RDM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9595:PPP6R3
gene id: 9595:PPP6R3
uniprot id: A0A2I2YMJ3
uniprot id: G3QUR8
uniprot id: G3S525
names: Similarity
messages: Belongs to the SAPS family.

9595:YKT6
gene id: 9595:YKT6
uniprot id: G3RTQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9595:ANKRD13C
gene id: 9595:ANKRD13C
uniprot id: G3S318
names: Subcellular Location Annotation
messages: Membrane

9595:MRPL42
gene id: 9595:MRPL42
uniprot id: G3RSP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9595:SPOCK1
gene id: 9595:SPOCK1
uniprot id: G3QEU5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:IFT46
gene id: 9595:IFT46
uniprot id: G3S8A9
uniprot id: G3S8P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9595:LOC101140206
gene id: 9595:LOC101140206
uniprot id: G3S1W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:KRT1
gene id: 9595:KRT1
uniprot id: G3QLP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9595:MPP1
gene id: 9595:MPP1
uniprot id: A0A2I2Z2Z7
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

9595:ATP5PD
gene id: 9595:ATP5PD
uniprot id: G3RCY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9595:RIGI
gene id: 9595:RIGI
uniprot id: G3S7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9595:HFE
gene id: 9595:HFE
uniprot id: G3QU39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
messages: Involved in the presentation of foreign antigens to the immune system.

9595:DKK2
gene id: 9595:DKK2
uniprot id: A0A2I2ZPL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9595:FOXI2
gene id: 9595:FOXI2
uniprot id: G3QV33
names: Subcellular Location Annotation
messages: Nucleus

9595:KIF1B
gene id: 9595:KIF1B
uniprot id: G3SEL4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:CPT2
gene id: 9595:CPT2
uniprot id: A0A2I2YJ86
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9595:IFT20
gene id: 9595:IFT20
uniprot id: A0A2I2Y652
uniprot id: A0A2I2ZW01
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9595:MLEC
gene id: 9595:MLEC
uniprot id: A0A2I2ZR40
uniprot id: G3QWB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LOC101147448
gene id: 9595:LOC101147448
uniprot id: A0A2I2YH02
names: Similarity
messages: Belongs to the UQCC4 family.

9595:RPS8
gene id: 9595:RPS8
uniprot id: G3QS94
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

9595:LOC101137142
gene id: 9595:LOC101137142
uniprot id: G3QR80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SLC2A4
gene id: 9595:SLC2A4
uniprot id: G3QWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9595:YPEL1
gene id: 9595:YPEL1
uniprot id: A0A2I2Y307
names: Similarity
messages: Belongs to the yippee family.

9595:RCE1
gene id: 9595:RCE1
uniprot id: G3REW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:ABCA1
gene id: 9595:ABCA1
uniprot id: G3R1Y5
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101125304
gene id: 9595:LOC101125304
uniprot id: G3RQI3
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:WNT6
gene id: 9595:WNT6
uniprot id: G3QL59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:SMG6
gene id: 9595:SMG6
uniprot id: G3RWH9
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.
messages: Plays a role in nonsense-mediated mRNA decay.
messages: The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.
messages: cytosol
messages: nucleolus
messages: telomere

9595:OLA1
gene id: 9595:OLA1
uniprot id: A0A2I2YI01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

9595:ENPP2
gene id: 9595:ENPP2
uniprot id: A0A2I2YZY5
uniprot id: G3QK63
uniprot id: G3RNC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9595:CIAO2A
gene id: 9595:CIAO2A
uniprot id: A0A2I2YYL6
uniprot id: G3RK86
names: Similarity
messages: Belongs to the MIP18 family.

9595:PLIN2
gene id: 9595:PLIN2
uniprot id: G3RK26
names: Similarity
messages: Belongs to the perilipin family.

9595:GRPEL2
gene id: 9595:GRPEL2
uniprot id: G3QRN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9595:HRK
gene id: 9595:HRK
uniprot id: G3QTJ6
names: Function
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Promotes apoptosis.

9595:PTPRE
gene id: 9595:PTPRE
uniprot id: A0A2I2Z3D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9595:RPL22L1
gene id: 9595:RPL22L1
uniprot id: A0A2I2ZLJ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9595:LANCL1
gene id: 9595:LANCL1
uniprot id: A0A2I2Z0V7
names: Similarity
messages: Belongs to the LanC-like protein family.

9595:GFRA2
gene id: 9595:GFRA2
uniprot id: G3RD05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

9595:SEPTIN10
gene id: 9595:SEPTIN10
uniprot id: A0A2I2YIZ9
uniprot id: A0A2I2ZL83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9595:ERLEC1
gene id: 9595:ERLEC1
uniprot id: A0A2I2YL59
uniprot id: G3QE52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9595:GYS1
gene id: 9595:GYS1
uniprot id: A0A2I2ZL86
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9595:RBBP4
gene id: 9595:RBBP4
uniprot id: A0A2I2ZFC8
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC22A12
gene id: 9595:SLC22A12
uniprot id: A0A2I2YYG0
names: Subcellular Location Annotation
messages: Membrane

9595:AGMAT
gene id: 9595:AGMAT
uniprot id: G3RGP9
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

9595:LOC101144859
gene id: 9595:LOC101144859
uniprot id: G3QXY3
names: Subcellular Location Annotation
messages: Membrane

9595:OAS3
gene id: 9595:OAS3
uniprot id: G3QYL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9595:SLC13A1
gene id: 9595:SLC13A1
uniprot id: G3QU34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9595:TMEM129
gene id: 9595:TMEM129
uniprot id: A0A2I2YUT9
uniprot id: A0A2I2Z010
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9595:LOXL4
gene id: 9595:LOXL4
uniprot id: G3QQ45
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9595:IFNG
gene id: 9595:IFNG
uniprot id: G3QT96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9595:MED30
gene id: 9595:MED30
uniprot id: G3R195
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9595:OSBPL7
gene id: 9595:OSBPL7
uniprot id: G3RH58
names: Similarity
messages: Belongs to the OSBP family.

9595:ANP32A
gene id: 9595:ANP32A
uniprot id: G3RHC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9595:SNAP25
gene id: 9595:SNAP25
uniprot id: A0A2I2YCP6
uniprot id: G3R985
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9595:SLC2A1
gene id: 9595:SLC2A1
uniprot id: G3RZS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Membrane
messages: Photoreceptor inner segment

9595:PAGE4
gene id: 9595:PAGE4
uniprot id: G3QDC4
names: Similarity
messages: Belongs to the GAGE family.

9595:NOB1
gene id: 9595:NOB1
uniprot id: G3SFM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9595:FGFR1OP2
gene id: 9595:FGFR1OP2
uniprot id: A0A2I2YCV1
uniprot id: G3SEJ1
names: Similarity
messages: Belongs to the SIKE family.

9595:CDC5L
gene id: 9595:CDC5L
uniprot id: A0A2I2YQW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEF1 family.
messages: Nucleus

9595:LOC101144003
gene id: 9595:LOC101144003
uniprot id: A0A2I2ZTU6
names: Similarity
messages: Belongs to the PRAME family.

9595:TRMT2B
gene id: 9595:TRMT2B
uniprot id: G3SG06
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:POLR3G
gene id: 9595:POLR3G
uniprot id: A0A2I2ZHI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9595:ATF7IP
gene id: 9595:ATF7IP
uniprot id: G3SB83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9595:MYBL1
gene id: 9595:MYBL1
uniprot id: A0A2I2ZYZ0
uniprot id: G3SHW4
names: Subcellular Location Annotation
messages: Nucleus

9595:LSM6
gene id: 9595:LSM6
uniprot id: G3QG40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9595:INPP1
gene id: 9595:INPP1
uniprot id: G3S588
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9595:LOC101137046
gene id: 9595:LOC101137046
uniprot id: G3QUU9
names: Similarity
messages: Belongs to the S-100 family.

9595:PYCR3
gene id: 9595:PYCR3
uniprot id: G3QIY3
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9595:BLMH
gene id: 9595:BLMH
uniprot id: G3QRX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9595:PLOD2
gene id: 9595:PLOD2
uniprot id: A0A2I2YIY7
uniprot id: G3REF3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9595:RPL6
gene id: 9595:RPL6
uniprot id: G3QLG0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9595:NGF
gene id: 9595:NGF
uniprot id: Q9N2F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: Endosome lumen
messages: Homodimer. The homodimer interacts with a single NTRK1 chain. The homodimer interacts with a single NGFR chain (By similarity). The NGF dimer interacts with a single SORCS2 chain (via extracellular domain). The NGF precursor (proNGF) binds to a receptor complex formed by SORT1 and NGFR, which leads to NGF endocytosis. Both mature NGF and the immature NGF precursor (proNGF) interact with SORCS2 and with the heterodimer formed by SORCS2 and NGFR (via extracellular domains). The NGF precursor (proNGF) has much higher affinity for SORCS2 than mature NGF. The NGF precursor (proNGF) has much higher affinity for SORT1 than mature NGF (By similarity). Interacts with ADAM10 in a divalent cation-dependent manner (By similarity).
messages: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).
messages: Secreted

9595:MDM1
gene id: 9595:MDM1
uniprot id: G3QKW2
uniprot id: G3RPR2
uniprot id: G3S171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9595:BPNT1
gene id: 9595:BPNT1
uniprot id: G3S9T6
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9595:GPD1
gene id: 9595:GPD1
uniprot id: G3R865
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9595:FOXO3
gene id: 9595:FOXO3
uniprot id: G3QLU0
names: Subcellular Location Annotation
messages: Nucleus

9595:MAP2K5
gene id: 9595:MAP2K5
uniprot id: A0A2I2ZBX6
uniprot id: A0A2I2ZQT1
uniprot id: G3QPY6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:SLC35E3
gene id: 9595:SLC35E3
uniprot id: G3SF52
names: Subcellular Location Annotation
messages: Membrane

9595:TSPYL6
gene id: 9595:TSPYL6
uniprot id: G3QKY2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9595:MVK
gene id: 9595:MVK
uniprot id: A0A2I2ZUP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm

9595:SLC52A1
gene id: 9595:SLC52A1
uniprot id: G3RHZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9595:INPP5J
gene id: 9595:INPP5J
uniprot id: A0A2I2ZYR0
uniprot id: G3QJK7
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9595:CRP
gene id: 9595:CRP
uniprot id: G3S3N2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:SNX14
gene id: 9595:SNX14
uniprot id: A0A2I2Y490
uniprot id: A0A2I2Y7X7
uniprot id: A0A2I2ZJ29
names: Similarity
messages: Belongs to the sorting nexin family.

9595:PRRT2
gene id: 9595:PRRT2
uniprot id: A0A2I2YQ23
uniprot id: A0A2I2ZU66
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:ADCK1
gene id: 9595:ADCK1
uniprot id: G3R379
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9595:SERPINB8
gene id: 9595:SERPINB8
uniprot id: G3R7L5
names: Similarity
messages: Belongs to the serpin family.

9595:HSPA4L
gene id: 9595:HSPA4L
uniprot id: G3RSH5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9595:QPCT
gene id: 9595:QPCT
uniprot id: G3QZV3
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9595:PLA2G2A
gene id: 9595:PLA2G2A
uniprot id: G3QZ00
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9595:LIPN
gene id: 9595:LIPN
uniprot id: G3QL72
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9595:CKS2
gene id: 9595:CKS2
uniprot id: G3S076
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9595:NPY1R
gene id: 9595:NPY1R
uniprot id: G3QP89
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:EGR1
gene id: 9595:EGR1
uniprot id: A0A2I2Y6K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9595:SDC1
gene id: 9595:SDC1
uniprot id: A0A2I2YZE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9595:RBBP5
gene id: 9595:RBBP5
uniprot id: G3RFR6
names: Subcellular Location Annotation
messages: Nucleus

9595:UCHL1
gene id: 9595:UCHL1
uniprot id: G3R0C8
names: Similarity
messages: Belongs to the peptidase C12 family.

9595:KIF19
gene id: 9595:KIF19
uniprot id: G3RLI9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:GDPD5
gene id: 9595:GDPD5
uniprot id: G3RIG1
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9595:TMSB15A
gene id: 9595:TMSB15A
uniprot id: G3RRF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9595:ZDHHC19
gene id: 9595:ZDHHC19
uniprot id: G3S9C6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:THADA
gene id: 9595:THADA
uniprot id: G3QXY5
names: Function
names: Similarity
messages: Belongs to the THADA family.
messages: Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.

9595:SPA17
gene id: 9595:SPA17
uniprot id: G3QMF2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9595:MSX2
gene id: 9595:MSX2
uniprot id: A1YF16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity).
messages: Belongs to the Msh homeobox family.
messages: Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).
messages: Nucleus

9595:FECH
gene id: 9595:FECH
uniprot id: G3S2X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

9595:RPL14
gene id: 9595:RPL14
uniprot id: G3S186
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9595:POLR3GL
gene id: 9595:POLR3GL
uniprot id: G3R856
uniprot id: G3SHQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9595:VNN3P
gene id: 9595:VNN3P
uniprot id: G3RP52
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9595:NLRP14
gene id: 9595:NLRP14
uniprot id: G3QDW2
names: Similarity
messages: Belongs to the NLRP family.

9595:SPRTN
gene id: 9595:SPRTN
uniprot id: G3QKV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9595:TOE1
gene id: 9595:TOE1
uniprot id: G3QL86
names: Similarity
messages: Belongs to the CAF1 family.

9595:CHRM2
gene id: 9595:CHRM2
uniprot id: A0A2I2YUP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9595:MAP4
gene id: 9595:MAP4
uniprot id: A0A2I2ZBP4
uniprot id: G3QNV8
names: Subcellular Location Annotation
messages: cytoskeleton

9595:PUS3
gene id: 9595:PUS3
uniprot id: G3RGD8
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9595:FANCC
gene id: 9595:FANCC
uniprot id: G3QT46
uniprot id: G3SD62
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.
messages: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
messages: Nucleus

9595:HTRA4
gene id: 9595:HTRA4
uniprot id: G3QTA2
names: Similarity
messages: Belongs to the peptidase S1C family.

9595:FSHR
gene id: 9595:FSHR
uniprot id: A0A2I2Z1U6
uniprot id: G3RET5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

9595:ACTL7B
gene id: 9595:ACTL7B
uniprot id: G3QYY8
names: Similarity
messages: Belongs to the actin family.

9595:COL4A1
gene id: 9595:COL4A1
uniprot id: G3RA04
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9595:TMEM70
gene id: 9595:TMEM70
uniprot id: G3RH79
names: Similarity
messages: Belongs to the TMEM70 family.

9595:RPLP1
gene id: 9595:RPLP1
uniprot id: G3S7X2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9595:DTWD2
gene id: 9595:DTWD2
uniprot id: A0A2I2YXC7
uniprot id: G3R2C7
names: Similarity
messages: Belongs to the TDD superfamily. DTWD2 family.

9595:ORC2
gene id: 9595:ORC2
uniprot id: A0A2I2ZLE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9595:TMBIM6
gene id: 9595:TMBIM6
uniprot id: A0A2I2Z4W6
uniprot id: G3S7K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9595:DYNLT5
gene id: 9595:DYNLT5
uniprot id: G3QIZ5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9595:KRT18
gene id: 9595:KRT18
uniprot id: G3R3T2
names: Similarity
messages: Belongs to the intermediate filament family.

9595:TAF6
gene id: 9595:TAF6
uniprot id: A0A2I2Y884
uniprot id: G3QJV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9595:TSPAN31
gene id: 9595:TSPAN31
uniprot id: G3SDI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:KDM4A
gene id: 9595:KDM4A
uniprot id: G3RYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9595:LOC101147326
gene id: 9595:LOC101147326
uniprot id: G3RL21
names: Similarity
messages: Belongs to the TACO1 family.

9595:KDELR1
gene id: 9595:KDELR1
uniprot id: G3RXH7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:NDST2
gene id: 9595:NDST2
uniprot id: G3QTP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9595:PKN2
gene id: 9595:PKN2
uniprot id: A0A2I2Z7U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9595:EPHB3
gene id: 9595:EPHB3
uniprot id: G3RJK3
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101128585
gene id: 9595:LOC101128585
uniprot id: A0A2I2ZHY0
uniprot id: A0A2I2ZQG9
uniprot id: A0A2I2ZXP0
uniprot id: G3RPF6
uniprot id: G3S8W3
uniprot id: G3SB82
uniprot id: G3SDQ1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9595:GPX8
gene id: 9595:GPX8
uniprot id: G3RA98
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9595:LPCAT2
gene id: 9595:LPCAT2
uniprot id: A0A2I2YGK6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9595:SLC6A14
gene id: 9595:SLC6A14
uniprot id: G3R5I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:NGLY1
gene id: 9595:NGLY1
uniprot id: G3QJW4
uniprot id: G3RSV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

9595:IRF2BP1
gene id: 9595:IRF2BP1
uniprot id: G3SFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9595:CDH5
gene id: 9595:CDH5
uniprot id: G3SFI0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:GKAP1
gene id: 9595:GKAP1
uniprot id: G3QS27
uniprot id: G3RXC6
names: Similarity
messages: Belongs to the GKAP1 family.

9595:AREG
gene id: 9595:AREG
uniprot id: G3R4Q9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ANXA7
gene id: 9595:ANXA7
uniprot id: A0A2I2ZQ69
uniprot id: G3QP82
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9595:TRPC6
gene id: 9595:TRPC6
uniprot id: G3R1D4
names: Subcellular Location Annotation
messages: Membrane

9595:EXOC3
gene id: 9595:EXOC3
uniprot id: A0A2I2YGD1
names: Similarity
messages: Belongs to the SEC6 family.

9595:GDPD3
gene id: 9595:GDPD3
uniprot id: G3R0Q2
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9595:SND1
gene id: 9595:SND1
uniprot id: G3R2E7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9595:ZFYVE16
gene id: 9595:ZFYVE16
uniprot id: G3S6W8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9595:ASB7
gene id: 9595:ASB7
uniprot id: A0A2I2ZMY0
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:FAM3C
gene id: 9595:FAM3C
uniprot id: G3RJZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9595:VGLL2
gene id: 9595:VGLL2
uniprot id: G3RDT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9595:LOC101141689
gene id: 9595:LOC101141689
uniprot id: G3QK27
names: Subcellular Location Annotation
messages: Membrane

9595:PTPN11
gene id: 9595:PTPN11
uniprot id: G3SJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9595:SLC24A2
gene id: 9595:SLC24A2
uniprot id: A0A2I2Z4V7
uniprot id: G3RK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9595:ZDHHC1
gene id: 9595:ZDHHC1
uniprot id: G3S107
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:TMOD3
gene id: 9595:TMOD3
uniprot id: A0A2I2YS59
names: Subcellular Location Annotation
messages: cytoskeleton

9595:POLD3
gene id: 9595:POLD3
uniprot id: G3RAT6
names: Subcellular Location Annotation
messages: Nucleus

9595:CRIPT
gene id: 9595:CRIPT
uniprot id: G3RGF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

9595:APOD
gene id: 9595:APOD
uniprot id: G3QHM6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.
messages: Secreted

9595:ADCYAP1
gene id: 9595:ADCYAP1
uniprot id: A0A2I2ZFM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9595:FAM135B
gene id: 9595:FAM135B
uniprot id: G3QWR5
names: Similarity
messages: Belongs to the FAM135 family.

9595:B4GALT4
gene id: 9595:B4GALT4
uniprot id: G3R771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9595:NBR1
gene id: 9595:NBR1
uniprot id: A0A2I2YAA1
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9595:LOC101153230
gene id: 9595:LOC101153230
uniprot id: G3QL22
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:CNKSR1
gene id: 9595:CNKSR1
uniprot id: G3SD79
names: Similarity
messages: Belongs to the CNKSR family.

9595:INTU
gene id: 9595:INTU
uniprot id: G3QKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

9595:RIPK2
gene id: 9595:RIPK2
uniprot id: G3R5J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments.

9595:RPN2
gene id: 9595:RPN2
uniprot id: G3SJW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9595:CUL5
gene id: 9595:CUL5
uniprot id: G3SHP7
names: Similarity
messages: Belongs to the cullin family.

9595:EDA
gene id: 9595:EDA
uniprot id: G3QSY7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9595:NIPBL
gene id: 9595:NIPBL
uniprot id: G3SDF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9595:TLL1
gene id: 9595:TLL1
uniprot id: G3QD43
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101139122
gene id: 9595:LOC101139122
uniprot id: G3RRH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101145787
gene id: 9595:LOC101145787
uniprot id: G3QEE1
uniprot id: G3RZY8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.

9595:IRF8
gene id: 9595:IRF8
uniprot id: G3S6K3
names: Subcellular Location Annotation
messages: Nucleus

9595:USP15
gene id: 9595:USP15
uniprot id: A0A2I2Y6G1
uniprot id: A0A2I2ZAZ8
uniprot id: G3QJX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9595:BZW2
gene id: 9595:BZW2
uniprot id: G3RS12
names: Similarity
messages: Belongs to the BZW family.

9595:MTHFD1
gene id: 9595:MTHFD1
uniprot id: G3QRA5
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9595:ZSCAN2
gene id: 9595:ZSCAN2
uniprot id: A0A2I2ZCF1
uniprot id: G3RF88
names: Subcellular Location Annotation
messages: Nucleus

9595:GRM2
gene id: 9595:GRM2
uniprot id: G3R3I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9595:OPN1SW
gene id: 9595:OPN1SW
uniprot id: G3QSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: perinuclear region
messages: photoreceptor outer segment

9595:LOC101135660
gene id: 9595:LOC101135660
uniprot id: G3QJI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MARK1
gene id: 9595:MARK1
uniprot id: A0A2I2Z1R1
uniprot id: G3QF81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9595:MCIDAS
gene id: 9595:MCIDAS
uniprot id: G3S280
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9595:TAF1
gene id: 9595:TAF1
uniprot id: A0A2I2ZUH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

9595:NUBP1
gene id: 9595:NUBP1
uniprot id: A0A2I2YWT3
uniprot id: G3QF82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9595:XAGE2
gene id: 9595:XAGE2
uniprot id: G3S4Q2
names: Similarity
messages: Belongs to the GAGE family.

9595:IRF9
gene id: 9595:IRF9
uniprot id: G3RIY4
names: Subcellular Location Annotation
messages: Nucleus

9595:HTR3E
gene id: 9595:HTR3E
uniprot id: G3SG94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9595:ZRANB2
gene id: 9595:ZRANB2
uniprot id: G3RPF8
uniprot id: G3SJM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9595:SF3B3
gene id: 9595:SF3B3
uniprot id: G3QL55
names: Subcellular Location Annotation
messages: Nucleus

9595:LAMP1
gene id: 9595:LAMP1
uniprot id: A0A2I2YGB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9595:LOC101128292
gene id: 9595:LOC101128292
uniprot id: G3QUL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9595:LOC101149433
gene id: 9595:LOC101149433
uniprot id: G3REX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
messages: Mitochondrion inner membrane

9595:CDK4
gene id: 9595:CDK4
uniprot id: G3QGD2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:USP5
gene id: 9595:USP5
uniprot id: G3QJI4
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:NEDD9
gene id: 9595:NEDD9
uniprot id: G3RJJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9595:OPTC
gene id: 9595:OPTC
uniprot id: G3RIQ6
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9595:ABCG1
gene id: 9595:ABCG1
uniprot id: A0A2I2ZSG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9595:CDC42BPG
gene id: 9595:CDC42BPG
uniprot id: G3QDM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm

9595:S100Z
gene id: 9595:S100Z
uniprot id: G3SJ08
names: Similarity
messages: Belongs to the S-100 family.

9595:CLSPN
gene id: 9595:CLSPN
uniprot id: G3QT52
names: Subcellular Location Annotation
messages: Nucleus

9595:MAP3K14
gene id: 9595:MAP3K14
uniprot id: G3QPG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9595:C3H3orf70
gene id: 9595:C3H3orf70
uniprot id: A0A2I2YBZ6
names: Similarity
messages: Belongs to the UPF0524 family.

9595:ST3GAL1
gene id: 9595:ST3GAL1
uniprot id: G3RUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:GGPS1
gene id: 9595:GGPS1
uniprot id: G3R0L0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9595:LOC101150071
gene id: 9595:LOC101150071
uniprot id: G3R7H3
names: Similarity
messages: Belongs to the actin family.

9595:ATL2
gene id: 9595:ATL2
uniprot id: A0A2I2Z6Z3
uniprot id: A0A2I2ZE35
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:SEZ6L2
gene id: 9595:SEZ6L2
uniprot id: A0A2I2YBM4
uniprot id: A0A2I2YE58
uniprot id: G3RHW1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:AKR1A1
gene id: 9595:AKR1A1
uniprot id: G3RAF6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9595:CEP76
gene id: 9595:CEP76
uniprot id: G3QZM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

9595:TMEM182
gene id: 9595:TMEM182
uniprot id: A0A2I2YIZ6
uniprot id: A0A2I2Z694
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9595:ATP5MF
gene id: 9595:ATP5MF
uniprot id: A0A2I2YV24
uniprot id: A0A2I2ZCK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9595:NSG2
gene id: 9595:NSG2
uniprot id: G3RAX5
names: Similarity
messages: Belongs to the NSG family.

9595:STAMBP
gene id: 9595:STAMBP
uniprot id: G3RXN2
names: Similarity
messages: Belongs to the peptidase M67C family.

9595:ACLY
gene id: 9595:ACLY
uniprot id: A0A2I2Y4J2
uniprot id: A0A2I2ZLM6
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9595:PLPP3
gene id: 9595:PLPP3
uniprot id: G3QDI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9595:PTPRU
gene id: 9595:PTPRU
uniprot id: G3QTZ2
uniprot id: G3SAR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9595:MYO19
gene id: 9595:MYO19
uniprot id: G3QY42
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:CTNNBIP1
gene id: 9595:CTNNBIP1
uniprot id: A0A2I2YTS2
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9595:HEPH
gene id: 9595:HEPH
uniprot id: G3R124
names: Similarity
messages: Belongs to the multicopper oxidase family.

9595:NOX1
gene id: 9595:NOX1
uniprot id: G3QVH2
names: Subcellular Location Annotation
messages: Membrane

9595:RGMA
gene id: 9595:RGMA
uniprot id: G3SH90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9595:CDR2L
gene id: 9595:CDR2L
uniprot id: G3S4H3
names: Similarity
messages: Belongs to the CDR2 family.

9595:KRT32
gene id: 9595:KRT32
uniprot id: G3RL19
names: Similarity
messages: Belongs to the intermediate filament family.

9595:DPCD
gene id: 9595:DPCD
uniprot id: G3QQQ9
names: Similarity
messages: Belongs to the DPCD family.

9595:TBX15
gene id: 9595:TBX15
uniprot id: G3RCB5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:IL23A
gene id: 9595:IL23A
uniprot id: G3QH19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9595:NAA10
gene id: 9595:NAA10
uniprot id: G3R2U7
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9595:FTSJ3
gene id: 9595:FTSJ3
uniprot id: G3QV89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

9595:MDN1
gene id: 9595:MDN1
uniprot id: G3SD94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

9595:GMNN
gene id: 9595:GMNN
uniprot id: G3R2B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9595:LOC101152722
gene id: 9595:LOC101152722
uniprot id: A0A2I2ZM97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9595:SEC61A1
gene id: 9595:SEC61A1
uniprot id: G3RUZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:HMGN2
gene id: 9595:HMGN2
uniprot id: G3QF88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9595:FIS1
gene id: 9595:FIS1
uniprot id: G3R091
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

9595:DKC1
gene id: 9595:DKC1
uniprot id: G3RNN2
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9595:MRC2
gene id: 9595:MRC2
uniprot id: G3QHG6
names: Subcellular Location Annotation
messages: Membrane

9595:AP4M1
gene id: 9595:AP4M1
uniprot id: A0A2I2Z0A9
uniprot id: G3QJU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
messages: Early endosome
messages: trans-Golgi network membrane

9595:GRK7
gene id: 9595:GRK7
uniprot id: G3RBR7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9595:KRT82
gene id: 9595:KRT82
uniprot id: G3QJZ6
names: Similarity
messages: Belongs to the intermediate filament family.

9595:TUT1
gene id: 9595:TUT1
uniprot id: G3RCJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Nucleus speckle
messages: nucleolus

9595:CTLA4
gene id: 9595:CTLA4
uniprot id: G3QY54
uniprot id: G3S368
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9595:URAD
gene id: 9595:URAD
uniprot id: G3QRV7
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9595:PDE5A
gene id: 9595:PDE5A
uniprot id: G3RCX2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:NCAPD3
gene id: 9595:NCAPD3
uniprot id: G3QV81
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

9595:OLFM3
gene id: 9595:OLFM3
uniprot id: A0A2I2YBG7
uniprot id: G3RLQ0
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9595:ADM
gene id: 9595:ADM
uniprot id: G3R6L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

9595:SLC25A44
gene id: 9595:SLC25A44
uniprot id: G3R5Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:SLCO6A1
gene id: 9595:SLCO6A1
uniprot id: G3RFJ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ALOX12B
gene id: 9595:ALOX12B
uniprot id: G3QSI2
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ATP5MC3
gene id: 9595:ATP5MC3
uniprot id: A0A2I2Z561
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9595:RUVBL2
gene id: 9595:RUVBL2
uniprot id: G3R1H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9595:PLXND1
gene id: 9595:PLXND1
uniprot id: G3QEM8
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PTGR1
gene id: 9595:PTGR1
uniprot id: A0A2I2Z9P7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9595:LOC101152497
gene id: 9595:LOC101152497
uniprot id: G3SK68
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9595:GABRP
gene id: 9595:GABRP
uniprot id: G3QMM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:LOC101129836
gene id: 9595:LOC101129836
uniprot id: G3QI19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:HDAC6
gene id: 9595:HDAC6
uniprot id: G3QPF0
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

9595:DPYS
gene id: 9595:DPYS
uniprot id: G3QDD2
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

9595:PRDM13
gene id: 9595:PRDM13
uniprot id: G3QVL8
names: Subcellular Location Annotation
messages: Nucleus

9595:BSX
gene id: 9595:BSX
uniprot id: G3QU78
names: Subcellular Location Annotation
messages: Nucleus

9595:CNTFR
gene id: 9595:CNTFR
uniprot id: G3QUF2
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9595:METTL14
gene id: 9595:METTL14
uniprot id: A0A2I2YEF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.

9595:DNPEP
gene id: 9595:DNPEP
uniprot id: A0A2I2ZMW2
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9595:PLOD3
gene id: 9595:PLOD3
uniprot id: G3RN67
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9595:LOC101141699
gene id: 9595:LOC101141699
uniprot id: G3QIY6
names: Subcellular Location Annotation
messages: Membrane

9595:DMRT3
gene id: 9595:DMRT3
uniprot id: G3RBV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9595:BSCL2
gene id: 9595:BSCL2
uniprot id: A0A2I2Z3C5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:PLXNC1
gene id: 9595:PLXNC1
uniprot id: G3RQ81
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CADM2
gene id: 9595:CADM2
uniprot id: A0A2I2YGT2
uniprot id: G3S6D6
names: Similarity
messages: Belongs to the nectin family.

9595:HAPLN3
gene id: 9595:HAPLN3
uniprot id: G3QRC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:GPR33
gene id: 9595:GPR33
uniprot id: G3S0S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9595:SYF2
gene id: 9595:SYF2
uniprot id: A0A2I2YYX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

9595:SERPINA5
gene id: 9595:SERPINA5
uniprot id: G3QHK3
names: Similarity
messages: Belongs to the serpin family.

9595:ASPA
gene id: 9595:ASPA
uniprot id: G3QQC1
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9595:NUP205
gene id: 9595:NUP205
uniprot id: G3R7B7
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

9595:RARS2
gene id: 9595:RARS2
uniprot id: G3R3G7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:REXO4
gene id: 9595:REXO4
uniprot id: G3RF01
names: Similarity
messages: Belongs to the REXO4 family.

9595:AUH
gene id: 9595:AUH
uniprot id: G3QML4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9595:PADI2
gene id: 9595:PADI2
uniprot id: G3RJJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9595:LOC101124851
gene id: 9595:LOC101124851
uniprot id: G3QVG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:AGXT2
gene id: 9595:AGXT2
uniprot id: G3QUN3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9595:CORO2A
gene id: 9595:CORO2A
uniprot id: G3R1C7
names: Similarity
messages: Belongs to the WD repeat coronin family.

9595:SLC22A9
gene id: 9595:SLC22A9
uniprot id: G3SB06
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101136745
gene id: 9595:LOC101136745
uniprot id: G3R5W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ATF1
gene id: 9595:ATF1
uniprot id: A0A2I2ZEL8
names: Subcellular Location Annotation
messages: Nucleus

9595:ITGA10
gene id: 9595:ITGA10
uniprot id: G3RHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:DPYSL3
gene id: 9595:DPYSL3
uniprot id: A0A2I2YG83
uniprot id: G3S4K1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9595:EIF2A
gene id: 9595:EIF2A
uniprot id: A0A2I2ZFS3
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9595:IL9
gene id: 9595:IL9
uniprot id: G3RE08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

9595:EIF5A2
gene id: 9595:EIF5A2
uniprot id: A0A2I2YC22
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

9595:GNB2
gene id: 9595:GNB2
uniprot id: G3QSP3
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9595:PEX12
gene id: 9595:PEX12
uniprot id: G3QLC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
messages: Membrane
messages: Peroxisome membrane

9595:LOC109029095
gene id: 9595:LOC109029095
uniprot id: A0A2I2YEJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9595:NPVF
gene id: 9595:NPVF
uniprot id: G3R8I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9595:TRMT112
gene id: 9595:TRMT112
uniprot id: G3QG66
names: Similarity
messages: Belongs to the TRM112 family.

9595:HTR3A
gene id: 9595:HTR3A
uniprot id: A0A2I2ZB92
uniprot id: G3RFI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane

9595:FAM161A
gene id: 9595:FAM161A
uniprot id: G3RDJ6
uniprot id: G3S668
names: Similarity
messages: Belongs to the FAM161 family.

9595:ABCD1
gene id: 9595:ABCD1
uniprot id: G3QS26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9595:NRCAM
gene id: 9595:NRCAM
uniprot id: A0A2I2YVR5
uniprot id: A0A2I2ZHX1
uniprot id: A0A2I2ZM62
uniprot id: A0A2I2ZNL1
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9595:PLCD1
gene id: 9595:PLCD1
uniprot id: G3QMJ5
uniprot id: G3RXS3
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9595:LOC109028370
gene id: 9595:LOC109028370
uniprot id: G3QR34
names: Subcellular Location Annotation
messages: Membrane

9595:TBX21
gene id: 9595:TBX21
uniprot id: G3QIG3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:MAP4K2
gene id: 9595:MAP4K2
uniprot id: G3QKE8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9595:NDUFAB1
gene id: 9595:NDUFAB1
uniprot id: Q0MQC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).
messages: Mammalian complex I is composed of 45 different subunits. Interacts with ETFRF1. Identified in a complex composed of MALSU1, MIEF1 upstream open reading frame protein and NDUFAB1; within the trimeric complex, MIEF1 upstream open reading frame protein functions as a bridging scaffold that interacts with MALSU1 on one side, and with NDUFAB1 on the other side. The complex interacts with the mitochondrial large ribosomal subunit. Interacts with alpha-1-microglobulin chain; this interaction is required for the maintenance of mitochondrial redox homeostasis. Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer. Component of the cyteine desulfurase complex composed of NFS1, LYRM4 and NDUFAB1; this complex contributes to the stability and cysteine desulfurase activity of NFS1.
messages: Mitochondrion
messages: Phosphopantetheinylation at Ser-112 is essential for interactions with LYR motif-containing proteins.

9595:ANKRD34B
gene id: 9595:ANKRD34B
uniprot id: A0A2I2ZNV7
names: Similarity
messages: Belongs to the ANKRD34 family.

9595:LEUTX
gene id: 9595:LEUTX
uniprot id: A0A2I2ZWG8
names: Subcellular Location Annotation
messages: Nucleus

9595:HAO2
gene id: 9595:HAO2
uniprot id: G3R1D9
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9595:GPM6A
gene id: 9595:GPM6A
uniprot id: A0A2I2YM05
uniprot id: A0A2I2ZRH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9595:LOC101138472
gene id: 9595:LOC101138472
uniprot id: G3RKB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:PDHB
gene id: 9595:PDHB
uniprot id: A0A2I2Y532
uniprot id: G3RBH2
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9595:RNF40
gene id: 9595:RNF40
uniprot id: G3RKQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9595:FMO3
gene id: 9595:FMO3
uniprot id: G3RKD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Membrane
messages: Microsome membrane

9595:OSBPL2
gene id: 9595:OSBPL2
uniprot id: G3QZF0
names: Similarity
messages: Belongs to the OSBP family.

9595:GPRIN2
gene id: 9595:GPRIN2
uniprot id: G3RB88
names: Function
messages: May be involved in neurite outgrowth.

9595:ZNF213
gene id: 9595:ZNF213
uniprot id: G3R8L7
names: Subcellular Location Annotation
messages: Nucleus

9595:NXPH4
gene id: 9595:NXPH4
uniprot id: G3R3Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9595:NT5DC2
gene id: 9595:NT5DC2
uniprot id: G3RIT6
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9595:HESX1
gene id: 9595:HESX1
uniprot id: G3QTP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

9595:ATP13A5
gene id: 9595:ATP13A5
uniprot id: G3QVW2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:RBM47
gene id: 9595:RBM47
uniprot id: G3S7F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Cytoplasm
messages: Nucleus

9595:TMEM35B
gene id: 9595:TMEM35B
uniprot id: G3S3L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9595:MEGF6
gene id: 9595:MEGF6
uniprot id: G3RQW9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TRPM6
gene id: 9595:TRPM6
uniprot id: A0A2I2YQ50
uniprot id: G3SJI9
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

9595:LOC101147918
gene id: 9595:LOC101147918
uniprot id: G3QXZ8
names: Similarity
messages: Belongs to the serpin family.

9595:SYPL2
gene id: 9595:SYPL2
uniprot id: G3RC44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9595:PCNX4
gene id: 9595:PCNX4
uniprot id: G3SD25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9595:ADPRS
gene id: 9595:ADPRS
uniprot id: G3QMG4
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9595:CDPF1
gene id: 9595:CDPF1
uniprot id: G3SJ38
names: Similarity
messages: Belongs to the CDPF1 family.

9595:TOMM7
gene id: 9595:TOMM7
uniprot id: A0A2I2Y7Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:CMAS
gene id: 9595:CMAS
uniprot id: G3RGF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

9595:LOC101129087
gene id: 9595:LOC101129087
uniprot id: G3R3C3
names: Similarity
messages: Belongs to the NUT family.

9595:LGI1
gene id: 9595:LGI1
uniprot id: G3QIJ9
names: Subcellular Location Annotation
messages: Secreted

9595:RETREG1
gene id: 9595:RETREG1
uniprot id: A0A2I2Y1L7
uniprot id: G3R4Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:CCSER1
gene id: 9595:CCSER1
uniprot id: A0A2I2YN34
uniprot id: G3RDV0
names: Similarity
messages: Belongs to the CCSER family.

9595:WDR91
gene id: 9595:WDR91
uniprot id: G3QF22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:SV2C
gene id: 9595:SV2C
uniprot id: G3QXL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9595:ELP3
gene id: 9595:ELP3
uniprot id: G3QQ56
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9595:TRIM9
gene id: 9595:TRIM9
uniprot id: G3QS61
names: Subcellular Location Annotation
messages: cytoskeleton

9595:HSPH1
gene id: 9595:HSPH1
uniprot id: G3S272
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9595:RPL38
gene id: 9595:RPL38
uniprot id: G3QET2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9595:TFAP2A
gene id: 9595:TFAP2A
uniprot id: A0A2I2Y2H6
uniprot id: A0A2I2Y342
uniprot id: G3QX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9595:DTX3L
gene id: 9595:DTX3L
uniprot id: G3RIS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9595:TUT7
gene id: 9595:TUT7
uniprot id: G3SAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

9595:PADI4
gene id: 9595:PADI4
uniprot id: G3RGW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9595:S100A5
gene id: 9595:S100A5
uniprot id: G3QWD1
names: Similarity
messages: Belongs to the S-100 family.

9595:UBL4A
gene id: 9595:UBL4A
uniprot id: G3RQ50
names: Subcellular Location Annotation
messages: cytosol

9595:FAM167B
gene id: 9595:FAM167B
uniprot id: G3S571
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9595:MAP1LC3C
gene id: 9595:MAP1LC3C
uniprot id: G3QDD6
names: Similarity
messages: Belongs to the ATG8 family.

9595:CYRIB
gene id: 9595:CYRIB
uniprot id: G3SFG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9595:TCEA2
gene id: 9595:TCEA2
uniprot id: G3QMP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9595:BAMBI
gene id: 9595:BAMBI
uniprot id: G3QPL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9595:ANXA6
gene id: 9595:ANXA6
uniprot id: G3QQY3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

9595:NDUFA4
gene id: 9595:NDUFA4
uniprot id: Q0MQ98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex IV NDUFA4 subunit family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance.
messages: Mitochondrion inner membrane

9595:KCND3
gene id: 9595:KCND3
uniprot id: A0A2I2YJE5
uniprot id: G3RHS4
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9595:TMEM144
gene id: 9595:TMEM144
uniprot id: G3RLJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9595:DLX1
gene id: 9595:DLX1
uniprot id: A0A2I2ZN57
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC19A3
gene id: 9595:SLC19A3
uniprot id: G3QNY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
messages: Membrane

9595:CASS4
gene id: 9595:CASS4
uniprot id: G3QNL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9595:CASP8
gene id: 9595:CASP8
uniprot id: A0A2I2YHY1
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:ABCB11
gene id: 9595:ABCB11
uniprot id: A0A2I2Z8S9
names: Subcellular Location Annotation
messages: Membrane

9595:IQCG
gene id: 9595:IQCG
uniprot id: A0A2I2Z7X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9595:CTNS
gene id: 9595:CTNS
uniprot id: A0A2I2Y463
uniprot id: G3R346
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9595:OTULINL
gene id: 9595:OTULINL
uniprot id: G3RDP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9595:RAB33A
gene id: 9595:RAB33A
uniprot id: G3SBQ8
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9595:IRF1
gene id: 9595:IRF1
uniprot id: G3RDI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9595:LOC101129723
gene id: 9595:LOC101129723
uniprot id: A1YF15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity (By similarity).

9595:TNFSF4
gene id: 9595:TNFSF4
uniprot id: G3RRJ0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9595:MTFR1
gene id: 9595:MTFR1
uniprot id: G3QWY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9595:LOC101142110
gene id: 9595:LOC101142110
uniprot id: G3R0R8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:PTGES3L
gene id: 9595:PTGES3L
uniprot id: A0A2I2Y205
names: Similarity
messages: Belongs to the p23/wos2 family.

9595:BCL2L1
gene id: 9595:BCL2L1
uniprot id: G3RY91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9595:GUCY2F
gene id: 9595:GUCY2F
uniprot id: G3QV59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9595:UNK
gene id: 9595:UNK
uniprot id: G3R1E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9595:TMEM237
gene id: 9595:TMEM237
uniprot id: G3QPW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9595:TMOD4
gene id: 9595:TMOD4
uniprot id: G3S261
names: Subcellular Location Annotation
messages: cytoskeleton

9595:TRHR
gene id: 9595:TRHR
uniprot id: G3RKI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9595:LOC101147034
gene id: 9595:LOC101147034
uniprot id: G3QTN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9595:CUL4A
gene id: 9595:CUL4A
uniprot id: A0A2I2Z909
uniprot id: G3QDT2
names: Similarity
messages: Belongs to the cullin family.

9595:NDUFA11
gene id: 9595:NDUFA11
uniprot id: Q0MQB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:APOO
gene id: 9595:APOO
uniprot id: G3QFV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9595:LOC101154451
gene id: 9595:LOC101154451
uniprot id: G3RU19
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:PSMA1
gene id: 9595:PSMA1
uniprot id: G3QGE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9595:GSTZ1
gene id: 9595:GSTZ1
uniprot id: G3QTP9
uniprot id: G3S5A6
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9595:ZC3H12B
gene id: 9595:ZC3H12B
uniprot id: G3SK26
names: Similarity
messages: Belongs to the ZC3H12 family.

9595:EFNA4
gene id: 9595:EFNA4
uniprot id: G3RDG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:S100PBP
gene id: 9595:S100PBP
uniprot id: G3QS48
names: Subcellular Location Annotation
messages: Nucleus

9595:CCNL2
gene id: 9595:CCNL2
uniprot id: A0A2I2Z213
uniprot id: G3QYV8
names: Similarity
messages: Belongs to the cyclin family.

9595:ARPP19
gene id: 9595:ARPP19
uniprot id: A0A2I2Y2C8
uniprot id: A0A2I2ZT76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9595:H1-3
gene id: 9595:H1-3
uniprot id: G3QW70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9595:NPAS4
gene id: 9595:NPAS4
uniprot id: G3QZU8
names: Subcellular Location Annotation
messages: Nucleus

9595:CMTM2
gene id: 9595:CMTM2
uniprot id: A0A2I2ZS98
names: Subcellular Location Annotation
messages: Membrane

9595:TCEAL1
gene id: 9595:TCEAL1
uniprot id: A1YEW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity).
messages: Nucleus

9595:PNKD
gene id: 9595:PNKD
uniprot id: G3QVH5
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9595:LOC101128201
gene id: 9595:LOC101128201
uniprot id: G3SI94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LSM5
gene id: 9595:LSM5
uniprot id: A0A2I2ZH19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9595:PEX19
gene id: 9595:PEX19
uniprot id: G3S3F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9595:EIF2B4
gene id: 9595:EIF2B4
uniprot id: G3R5X2
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9595:GBP2
gene id: 9595:GBP2
uniprot id: G3QH70
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:TEKT5
gene id: 9595:TEKT5
uniprot id: G3QVU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9595:TAAR5
gene id: 9595:TAAR5
uniprot id: G3QZ92
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:POT1
gene id: 9595:POT1
uniprot id: G3RFG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9595:CALCA
gene id: 9595:CALCA
uniprot id: G3RE30
names: Similarity
messages: Belongs to the calcitonin family.

9595:CEP55
gene id: 9595:CEP55
uniprot id: A0A2I2YRV3
names: Subcellular Location Annotation
messages: Cytoplasm

9595:TIMM10
gene id: 9595:TIMM10
uniprot id: G3R9P2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9595:SLC12A4
gene id: 9595:SLC12A4
uniprot id: A0A2I2YNR3
uniprot id: A0A2I2ZJH0
uniprot id: A0A2I2ZQL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9595:NPM1
gene id: 9595:NPM1
uniprot id: A0A2I2YQY6
uniprot id: G3QWA8
names: Similarity
messages: Belongs to the nucleoplasmin family.

9595:HOXB1
gene id: 9595:HOXB1
uniprot id: G3R355
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9595:EPN2
gene id: 9595:EPN2
uniprot id: G3RLB9
uniprot id: G3RRH0
names: Similarity
messages: Belongs to the epsin family.

9595:HIGD2B
gene id: 9595:HIGD2B
uniprot id: G3RH47
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9595:WDR83OS
gene id: 9595:WDR83OS
uniprot id: G3RC27
names: Similarity
messages: Belongs to the Asterix family.

9595:SUPT6H
gene id: 9595:SUPT6H
uniprot id: G3RKN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9595:PSIP1
gene id: 9595:PSIP1
uniprot id: G3RJ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9595:FOXL1
gene id: 9595:FOXL1
uniprot id: G3RF46
names: Subcellular Location Annotation
messages: Nucleus

9595:MGP
gene id: 9595:MGP
uniprot id: A0A2I2Z0Z1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9595:SMDT1
gene id: 9595:SMDT1
uniprot id: G3QY06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9595:ZDHHC5
gene id: 9595:ZDHHC5
uniprot id: G3QDT7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:LTBR
gene id: 9595:LTBR
uniprot id: G3R5J9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101130647
gene id: 9595:LOC101130647
uniprot id: A0A2I2Z622
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:IL10
gene id: 9595:IL10
uniprot id: G3REF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9595:ZCCHC4
gene id: 9595:ZCCHC4
uniprot id: G3S195
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9595:HSPA5
gene id: 9595:HSPA5
uniprot id: G3S6H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cell surface
messages: Endoplasmic reticulum lumen
messages: Melanosome

9595:RAB5IF
gene id: 9595:RAB5IF
uniprot id: G3RXB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LOC101128885
gene id: 9595:LOC101128885
uniprot id: G3QPL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:AMD1
gene id: 9595:AMD1
uniprot id: G3QUC4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9595:MFGE8
gene id: 9595:MFGE8
uniprot id: G3RF38
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:DNM1L
gene id: 9595:DNM1L
uniprot id: A0A2I2Z6J7
uniprot id: A0A2I2ZBB8
uniprot id: A0A2I2ZQQ6
uniprot id: G3SH34
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9595:LOC101138548
gene id: 9595:LOC101138548
uniprot id: G3QSL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9595:TMCC2
gene id: 9595:TMCC2
uniprot id: G3S0X2
names: Similarity
messages: Belongs to the TEX28 family.

9595:SLC22A5
gene id: 9595:SLC22A5
uniprot id: G3QFF2
uniprot id: G3RTQ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane
messages: Interacts with PDZK1.

9595:ALDOB
gene id: 9595:ALDOB
uniprot id: A0A2I2ZJH2
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9595:HEATR1
gene id: 9595:HEATR1
uniprot id: A0A2I2Z2B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9595:ADD3
gene id: 9595:ADD3
uniprot id: A0A2I2ZPJ2
uniprot id: G3RP35
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9595:DDR1
gene id: 9595:DDR1
uniprot id: A0A2I2YE95
uniprot id: G3RFJ9
names: Subcellular Location Annotation
messages: Membrane

9595:RCAN3
gene id: 9595:RCAN3
uniprot id: G3RC15
names: Similarity
messages: Belongs to the RCAN family.

9595:PPP4R3C
gene id: 9595:PPP4R3C
uniprot id: G3S742
names: Similarity
messages: Belongs to the SMEK family.

9595:LSM7
gene id: 9595:LSM7
uniprot id: G3R3U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9595:RPS5
gene id: 9595:RPS5
uniprot id: A0A2I2Z9R5
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9595:TPH1
gene id: 9595:TPH1
uniprot id: G3RMB3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9595:PHKA2
gene id: 9595:PHKA2
uniprot id: G3S081
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9595:HOXA2
gene id: 9595:HOXA2
uniprot id: G3QIG7
names: Subcellular Location Annotation
messages: Nucleus

9595:MRPL46
gene id: 9595:MRPL46
uniprot id: G3RGM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9595:MFF
gene id: 9595:MFF
uniprot id: A0A2I2YW07
uniprot id: A0A2I2ZM93
uniprot id: G3RL80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
messages: synaptic vesicle

9595:RDH14
gene id: 9595:RDH14
uniprot id: G3R8I8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:GGA1
gene id: 9595:GGA1
uniprot id: A0A2I2Z8T1
uniprot id: G3RF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9595:PRRX1
gene id: 9595:PRRX1
uniprot id: G3R3W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9595:LOC109024295
gene id: 9595:LOC109024295
uniprot id: G3S6W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9595:UTP25
gene id: 9595:UTP25
uniprot id: G3QTQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9595:LOC101151505
gene id: 9595:LOC101151505
uniprot id: A0A2I2YSK2
uniprot id: A0A2I2ZCP3
uniprot id: A0A2I2ZMB1
names: Similarity
messages: Belongs to the GroES chaperonin family.
messages: Belongs to the MOB1/phocein family.

9595:CD79B
gene id: 9595:CD79B
uniprot id: A0A2I2YUB3
uniprot id: G3R9W5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:ST8SIA1
gene id: 9595:ST8SIA1
uniprot id: G3QGC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:KCNK18
gene id: 9595:KCNK18
uniprot id: G3SCI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:LACC1
gene id: 9595:LACC1
uniprot id: G3R0P4
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9595:EXT2
gene id: 9595:EXT2
uniprot id: G3R5A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:KCTD13
gene id: 9595:KCTD13
uniprot id: G3RHW8
names: Similarity
messages: Belongs to the BACURD family.

9595:SLC30A2
gene id: 9595:SLC30A2
uniprot id: G3RJW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9595:MS4A6A
gene id: 9595:MS4A6A
uniprot id: G3RGN9
names: Similarity
messages: Belongs to the MS4A family.

9595:BDKRB2
gene id: 9595:BDKRB2
uniprot id: G3RCA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9595:FXYD3
gene id: 9595:FXYD3
uniprot id: G3SIJ8
names: Caution
names: Similarity
messages: Belongs to the FXYD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CR2
gene id: 9595:CR2
uniprot id: A0A2I2Y6U3
uniprot id: G3QLP1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101123729
gene id: 9595:LOC101123729
uniprot id: G3QT24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:APH1B
gene id: 9595:APH1B
uniprot id: A0A2I2ZC70
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9595:HCN3
gene id: 9595:HCN3
uniprot id: G3RJ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9595:LNPK
gene id: 9595:LNPK
uniprot id: G3QXW4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9595:RNMT
gene id: 9595:RNMT
uniprot id: G3QRZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9595:NOP10
gene id: 9595:NOP10
uniprot id: G3QFH4
names: Similarity
messages: Belongs to the NOP10 family.

9595:ALOX15B
gene id: 9595:ALOX15B
uniprot id: G3REL4
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CD93
gene id: 9595:CD93
uniprot id: A0A2I2ZW40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SS18
gene id: 9595:SS18
uniprot id: A0A2I2YW77
uniprot id: G3QP88
names: Similarity
messages: Belongs to the SS18 family.

9595:LPAR5
gene id: 9595:LPAR5
uniprot id: G3QHS3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:SLC35A2
gene id: 9595:SLC35A2
uniprot id: A0A2I2Y8V7
uniprot id: G3S1I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:CCSER2
gene id: 9595:CCSER2
uniprot id: G3QKL0
uniprot id: G3S2Y5
names: Similarity
messages: Belongs to the CCSER family.

9595:PDE4B
gene id: 9595:PDE4B
uniprot id: A0A2I2YS69
uniprot id: G3S4M8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:FHIP1B
gene id: 9595:FHIP1B
uniprot id: G3RIW5
names: Similarity
messages: Belongs to the FHIP family.

9595:MRPS18A
gene id: 9595:MRPS18A
uniprot id: G3SCE1
names: Subcellular Location Annotation
messages: Mitochondrion

9595:NOTO
gene id: 9595:NOTO
uniprot id: G3RF60
names: Subcellular Location Annotation
messages: Nucleus

9595:IL1RL2
gene id: 9595:IL1RL2
uniprot id: G3QLE3
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9595:CORIN
gene id: 9595:CORIN
uniprot id: G3R6C3
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LECT2
gene id: 9595:LECT2
uniprot id: G3S367
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9595:MYO1G
gene id: 9595:MYO1G
uniprot id: G3R5P5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:SERINC5
gene id: 9595:SERINC5
uniprot id: A0A2I2Z063
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9595:ELK4
gene id: 9595:ELK4
uniprot id: G3RX51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:HSPA14
gene id: 9595:HSPA14
uniprot id: G3QPS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9595:CLN3
gene id: 9595:CLN3
uniprot id: A0A2I2Y7A6
uniprot id: A0A2I2YA61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

9595:PCOLCE2
gene id: 9595:PCOLCE2
uniprot id: G3QXX6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:TMEM131
gene id: 9595:TMEM131
uniprot id: G3QGP6
names: Similarity
messages: Belongs to the TMEM131 family.

9595:HOXA10
gene id: 9595:HOXA10
uniprot id: A0A2I2YIN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9595:TCAF1
gene id: 9595:TCAF1
uniprot id: A0A2I2YSE4
names: Similarity
messages: Belongs to the TCAF family.

9595:POPDC2
gene id: 9595:POPDC2
uniprot id: G3QNZ3
names: Similarity
messages: Belongs to the popeye family.

9595:FXYD6
gene id: 9595:FXYD6
uniprot id: G3QUD2
names: Similarity
messages: Belongs to the FXYD family.

9595:PRORP
gene id: 9595:PRORP
uniprot id: G3R970
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9595:MEF2D
gene id: 9595:MEF2D
uniprot id: A0A2I2ZB37
uniprot id: G3SH47
names: Subcellular Location Annotation
messages: Nucleus

9595:HYAL2
gene id: 9595:HYAL2
uniprot id: G3QW01
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9595:SLC4A8
gene id: 9595:SLC4A8
uniprot id: G3R9D5
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9595:HCRTR2
gene id: 9595:HCRTR2
uniprot id: G3SII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:FEN1
gene id: 9595:FEN1
uniprot id: G3RA03
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Mitochondrion
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9595:LRRC42
gene id: 9595:LRRC42
uniprot id: G3R555
names: Similarity
messages: Belongs to the LRRC42 family.

9595:CBS
gene id: 9595:CBS
uniprot id: G3RQH5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

9595:MAPK10
gene id: 9595:MAPK10
uniprot id: A0A2I2ZN14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9595:UFM1
gene id: 9595:UFM1
uniprot id: A0A2I2YYE6
uniprot id: G3SHJ8
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9595:XPO6
gene id: 9595:XPO6
uniprot id: G3QS71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9595:PEX5
gene id: 9595:PEX5
uniprot id: G3QL79
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9595:FAM210B
gene id: 9595:FAM210B
uniprot id: A0A2I2ZUQ0
names: Similarity
messages: Belongs to the FAM210 family.

9595:LOC101148218
gene id: 9595:LOC101148218
uniprot id: G3SHA6
names: Subcellular Location Annotation
messages: Membrane

9595:NUP58
gene id: 9595:NUP58
uniprot id: A0A2I2YV67
uniprot id: G3QM84
names: Subcellular Location Annotation
messages: nuclear pore complex

9595:PDE4C
gene id: 9595:PDE4C
uniprot id: A0A2I2ZKK2
uniprot id: A0A2I2ZN78
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:TAS2R60
gene id: 9595:TAS2R60
uniprot id: G3QLM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:LOC101138393
gene id: 9595:LOC101138393
uniprot id: G3SF23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101133937
gene id: 9595:LOC101133937
uniprot id: G3QE41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LTA
gene id: 9595:LTA
uniprot id: G3QT71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9595:SLC9A4
gene id: 9595:SLC9A4
uniprot id: G3RF66
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9595:SLC25A1
gene id: 9595:SLC25A1
uniprot id: G3QTN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:LIPK
gene id: 9595:LIPK
uniprot id: G3QKZ9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9595:CLDN15
gene id: 9595:CLDN15
uniprot id: G3SCY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:ARSD
gene id: 9595:ARSD
uniprot id: G3SAU8
names: Similarity
messages: Belongs to the sulfatase family.

9595:LOC101127738
gene id: 9595:LOC101127738
uniprot id: G3RQ76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:KIF18B
gene id: 9595:KIF18B
uniprot id: G3RB73
uniprot id: G3RZM8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:TMEM265
gene id: 9595:TMEM265
uniprot id: A0A2I2ZSA5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9595:CDCA7
gene id: 9595:CDCA7
uniprot id: G3QH14
uniprot id: G3S418
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:DPYSL2
gene id: 9595:DPYSL2
uniprot id: A0A2I2Y6Z9
uniprot id: G3QD81
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9595:PHOSPHO2
gene id: 9595:PHOSPHO2
uniprot id: G3QTS4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9595:AP1M1
gene id: 9595:AP1M1
uniprot id: G3QNY3
uniprot id: G3SK90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9595:ADAMTS5
gene id: 9595:ADAMTS5
uniprot id: G3QVR6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:STX17
gene id: 9595:STX17
uniprot id: G3RAT0
names: Similarity
messages: Belongs to the syntaxin family.

9595:WASF1
gene id: 9595:WASF1
uniprot id: G3QWL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9595:PIK3IP1
gene id: 9595:PIK3IP1
uniprot id: A0A2I2ZGG3
uniprot id: G3QR65
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LYPLAL1
gene id: 9595:LYPLAL1
uniprot id: G3QHC1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9595:PDGFRA
gene id: 9595:PDGFRA
uniprot id: G3R4Z2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9595:TRABD2B
gene id: 9595:TRABD2B
uniprot id: A0A2I2YYI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9595:MTERF3
gene id: 9595:MTERF3
uniprot id: G3R7B6
names: Similarity
messages: Belongs to the mTERF family.

9595:RMI1
gene id: 9595:RMI1
uniprot id: G3RE68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9595:SLC25A52
gene id: 9595:SLC25A52
uniprot id: A0A2I2Z1D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:TDGF1
gene id: 9595:TDGF1
uniprot id: G3QLN2
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CSNK1A1
gene id: 9595:CSNK1A1
uniprot id: A0A2I2ZQU5
uniprot id: G3RDH8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:OCEL1
gene id: 9595:OCEL1
uniprot id: G3R5W8
names: Similarity
messages: Belongs to the ELL/occludin family.

9595:BANF1
gene id: 9595:BANF1
uniprot id: G3S5Z8
names: Subcellular Location Annotation
messages: Nucleus

9595:DNAJC10
gene id: 9595:DNAJC10
uniprot id: G3R967
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.
messages: Endoplasmic reticulum lumen

9595:OXR1
gene id: 9595:OXR1
uniprot id: A0A2I2YQR4
uniprot id: A0A2I2ZKZ2
uniprot id: G3QTR9
names: Similarity
messages: Belongs to the OXR1 family.

9595:PTGER3
gene id: 9595:PTGER3
uniprot id: A0A2I2ZEG4
uniprot id: A0A2I2ZTQ7
uniprot id: G3QE87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:NPC2
gene id: 9595:NPC2
uniprot id: G3RAU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9595:KCNE5
gene id: 9595:KCNE5
uniprot id: G3QZU7
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9595:EEIG1
gene id: 9595:EEIG1
uniprot id: G3RFH0
names: Similarity
messages: Belongs to the EEIG family.

9595:APEX2
gene id: 9595:APEX2
uniprot id: G3QI28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9595:GNA12
gene id: 9595:GNA12
uniprot id: G3R227
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9595:PTDSS1
gene id: 9595:PTDSS1
uniprot id: G3SCJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:SOST
gene id: 9595:SOST
uniprot id: G3QKL9
names: Similarity
messages: Belongs to the sclerostin family.

9595:LOC101153729
gene id: 9595:LOC101153729
uniprot id: G3QX37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9595:TBX10
gene id: 9595:TBX10
uniprot id: G3SF29
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:GPLD1
gene id: 9595:GPLD1
uniprot id: A0A2I2YDH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

9595:AMPD1
gene id: 9595:AMPD1
uniprot id: A0A2I2YPD9
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9595:GCNT2
gene id: 9595:GCNT2
uniprot id: G3QQ11
uniprot id: G3S2G6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9595:TLR3
gene id: 9595:TLR3
uniprot id: G3SGL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9595:FIP1L1
gene id: 9595:FIP1L1
uniprot id: A0A2I2Y6Z7
uniprot id: G3SBL8
uniprot id: G3SJN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9595:RPL24
gene id: 9595:RPL24
uniprot id: G3R7I4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9595:KIFC1
gene id: 9595:KIFC1
uniprot id: G3QDE3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:UBE2D4
gene id: 9595:UBE2D4
uniprot id: A0A2I2ZSM0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:LOC101152944
gene id: 9595:LOC101152944
uniprot id: G3QS30
names: Similarity
messages: Belongs to the folate receptor family.

9595:FAR1
gene id: 9595:FAR1
uniprot id: A0A2I2YI16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9595:PSMA8
gene id: 9595:PSMA8
uniprot id: G3RJT2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9595:BEX5
gene id: 9595:BEX5
uniprot id: G3SE44
names: Similarity
messages: Belongs to the BEX family.

9595:FOXP1
gene id: 9595:FOXP1
uniprot id: G3SIY1
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC9C2
gene id: 9595:SLC9C2
uniprot id: G3R4F4
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9595:MRPS21
gene id: 9595:MRPS21
uniprot id: G3S8Y8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9595:DCTN5
gene id: 9595:DCTN5
uniprot id: G3RAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

9595:EML2
gene id: 9595:EML2
uniprot id: G3RHI7
uniprot id: G3S867
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9595:RHCG
gene id: 9595:RHCG
uniprot id: G3RHG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9595:UGCG
gene id: 9595:UGCG
uniprot id: G3S910
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9595:ARAF
gene id: 9595:ARAF
uniprot id: G3R027
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9595:OXSR1
gene id: 9595:OXSR1
uniprot id: G3QU09
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9595:KIF3A
gene id: 9595:KIF3A
uniprot id: G3S0E8
uniprot id: G3SK66
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:ACRBP
gene id: 9595:ACRBP
uniprot id: G3RZK8
names: Subcellular Location Annotation
messages: acrosome

9595:ZNF496
gene id: 9595:ZNF496
uniprot id: G3RYY8
names: Subcellular Location Annotation
messages: Nucleus

9595:IL12RB1
gene id: 9595:IL12RB1
uniprot id: G3QKI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9595:LOC101130182
gene id: 9595:LOC101130182
uniprot id: A0A2I2ZU56
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:LOC101147167
gene id: 9595:LOC101147167
uniprot id: G3SG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ATP6V1H
gene id: 9595:ATP6V1H
uniprot id: A0A2I2Z4M8
uniprot id: G3QE24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:ACADL
gene id: 9595:ACADL
uniprot id: G3QUJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

9595:LEAP2
gene id: 9595:LEAP2
uniprot id: G3RTZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9595:HMGA1
gene id: 9595:HMGA1
uniprot id: G3SHP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9595:BLM
gene id: 9595:BLM
uniprot id: G3QXK2
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

9595:CTPS1
gene id: 9595:CTPS1
uniprot id: G3RLW2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9595:NGB
gene id: 9595:NGB
uniprot id: G3QTM7
names: Similarity
messages: Belongs to the globin family.

9595:CHRM5
gene id: 9595:CHRM5
uniprot id: G3RNL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9595:EHD3
gene id: 9595:EHD3
uniprot id: G3QKK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9595:SCRIB
gene id: 9595:SCRIB
uniprot id: A0A2I2ZWD7
uniprot id: G3RNP1
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9595:MEF2B
gene id: 9595:MEF2B
uniprot id: G3SEK6
names: Subcellular Location Annotation
messages: Nucleus

9595:DYSF
gene id: 9595:DYSF
uniprot id: A0A2I2Y9X0
uniprot id: A0A2I2ZVY1
uniprot id: G3QWB2
uniprot id: G3S7Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9595:LYN
gene id: 9595:LYN
uniprot id: G3R9U2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9595:MAGT1
gene id: 9595:MAGT1
uniprot id: G3R499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:CDKN1C
gene id: 9595:CDKN1C
uniprot id: A0A2I2ZXY1
uniprot id: G3SEB2
names: Similarity
messages: Belongs to the CDI family.

9595:OTOP2
gene id: 9595:OTOP2
uniprot id: G3QLB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9595:LHFPL1
gene id: 9595:LHFPL1
uniprot id: G3R4A6
names: Subcellular Location Annotation
messages: Membrane

9595:APP
gene id: 9595:APP
uniprot id: A0A2I2Y2N3
uniprot id: A0A2I2YBB2
uniprot id: G3QD87
uniprot id: G3S7J3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Secreted
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9595:ARTN
gene id: 9595:ARTN
uniprot id: G3RJS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9595:TRAPPC4
gene id: 9595:TRAPPC4
uniprot id: G3QJK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9595:TOP3A
gene id: 9595:TOP3A
uniprot id: G3QKQ6
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9595:EVC
gene id: 9595:EVC
uniprot id: G3RCZ5
names: Subcellular Location Annotation
messages: Membrane
messages: cilium basal body
messages: cilium membrane

9595:DEFB1
gene id: 9595:DEFB1
uniprot id: Q95M68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
messages: Membrane
messages: Monomer. Homodimer.
messages: Secreted

9595:TMEM138
gene id: 9595:TMEM138
uniprot id: G3QN90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9595:PIH1D2
gene id: 9595:PIH1D2
uniprot id: A0A2I2ZHK0
names: Similarity
messages: Belongs to the PIH1 family.

9595:CPSF2
gene id: 9595:CPSF2
uniprot id: G3R814
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9595:TNFRSF19
gene id: 9595:TNFRSF19
uniprot id: A0A2I2ZXF3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PHF20L1
gene id: 9595:PHF20L1
uniprot id: A0A2I2YQM9
uniprot id: A0A2I2ZRI2
names: Subcellular Location Annotation
messages: Nucleus

9595:PPP1R3C
gene id: 9595:PPP1R3C
uniprot id: A0A2I2YWD3
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9595:BAG6
gene id: 9595:BAG6
uniprot id: A0A2I2ZNR6
uniprot id: G3QS02
uniprot id: G3SDX2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: cytosol
messages: extracellular exosome

9595:LOC101129101
gene id: 9595:LOC101129101
uniprot id: G3QKI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ROPN1L
gene id: 9595:ROPN1L
uniprot id: G3QQG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

9595:LOC101128717
gene id: 9595:LOC101128717
uniprot id: G3QMJ9
names: Subcellular Location Annotation
messages: Membrane

9595:WNT2
gene id: 9595:WNT2
uniprot id: Q2IBF4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

9595:MFAP1
gene id: 9595:MFAP1
uniprot id: A0A2I2YJD5
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9595:WT1
gene id: 9595:WT1
uniprot id: G3RQ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

9595:GAST
gene id: 9595:GAST
uniprot id: G3RKF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9595:SLC7A5
gene id: 9595:SLC7A5
uniprot id: G3SJE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9595:FAM199X
gene id: 9595:FAM199X
uniprot id: G3RZE4
names: Similarity
messages: Belongs to the FAM199 family.

9595:MON2
gene id: 9595:MON2
uniprot id: G3R8U3
uniprot id: G3SEK7
names: Similarity
messages: Belongs to the MON2 family.

9595:PPIL3
gene id: 9595:PPIL3
uniprot id: G3SGD0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9595:PKN1
gene id: 9595:PKN1
uniprot id: A0A2I2Y7S7
uniprot id: G3RIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9595:UROS
gene id: 9595:UROS
uniprot id: G3R707
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9595:LOC101141032
gene id: 9595:LOC101141032
uniprot id: A0A2I2ZKH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9595:PSMD5
gene id: 9595:PSMD5
uniprot id: A0A2I2Y2G6
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9595:LOC101143132
gene id: 9595:LOC101143132
uniprot id: G3QYB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:GAL
gene id: 9595:GAL
uniprot id: G3QDD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

9595:CPEB3
gene id: 9595:CPEB3
uniprot id: A0A2I2ZU18
names: Similarity
messages: Belongs to the RRM CPEB family.

9595:KIF16B
gene id: 9595:KIF16B
uniprot id: A0A2I2YQX1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:PSMA6
gene id: 9595:PSMA6
uniprot id: G3RBL9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9595:E2F5
gene id: 9595:E2F5
uniprot id: G3R2Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:PGM2L1
gene id: 9595:PGM2L1
uniprot id: G3QXX0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9595:CMTM1
gene id: 9595:CMTM1
uniprot id: G3QNG6
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101129979
gene id: 9595:LOC101129979
uniprot id: G3RQU6
names: Subcellular Location Annotation
messages: Membrane

9595:UROC1
gene id: 9595:UROC1
uniprot id: G3S3N4
names: Similarity
messages: Belongs to the urocanase family.

9595:PKM
gene id: 9595:PKM
uniprot id: A0A2I2YRU7
uniprot id: G3QQT8
uniprot id: G3S8Q3
names: Similarity
messages: Belongs to the pyruvate kinase family.

9595:SAMD4A
gene id: 9595:SAMD4A
uniprot id: A0A2I2YXP4
uniprot id: G3QEG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9595:LOC101126699
gene id: 9595:LOC101126699
uniprot id: G3RY77
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9595:CCR7
gene id: 9595:CCR7
uniprot id: G3RJP4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:RPL7L1
gene id: 9595:RPL7L1
uniprot id: G3S2G9
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9595:SNX1
gene id: 9595:SNX1
uniprot id: A0A2I2YF74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9595:GPRC6A
gene id: 9595:GPRC6A
uniprot id: G3QFV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:SCAMP5
gene id: 9595:SCAMP5
uniprot id: G3SAX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9595:TLE1
gene id: 9595:TLE1
uniprot id: G3QEP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9595:CD164L2
gene id: 9595:CD164L2
uniprot id: G3RR38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9595:MED10
gene id: 9595:MED10
uniprot id: G3QKQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:ATP6V0B
gene id: 9595:ATP6V0B
uniprot id: A0A2I2ZUX7
uniprot id: G3QM50
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9595:HTN1
gene id: 9595:HTN1
uniprot id: G3QQV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

9595:RELT
gene id: 9595:RELT
uniprot id: G3R437
names: Similarity
messages: Belongs to the RELT family.

9595:SRP14
gene id: 9595:SRP14
uniprot id: G3R367
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

9595:NPBWR1
gene id: 9595:NPBWR1
uniprot id: G3RGV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MAPK1
gene id: 9595:MAPK1
uniprot id: G3R7J0
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola
messages: focal adhesion

9595:DEGS2
gene id: 9595:DEGS2
uniprot id: G3QSW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LOC101132260
gene id: 9595:LOC101132260
uniprot id: A0A2I2YFF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ACVR1
gene id: 9595:ACVR1
uniprot id: G3QKB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9595:CDKN1B
gene id: 9595:CDKN1B
uniprot id: G3SDA9
names: Similarity
messages: Belongs to the CDI family.

9595:NTNG1
gene id: 9595:NTNG1
uniprot id: A0A2I2Z1B1
uniprot id: A0A2I2ZTW9
uniprot id: A0A2I2ZWL1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:USP16
gene id: 9595:USP16
uniprot id: A0A2I2YYF5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9595:AVPR1B
gene id: 9595:AVPR1B
uniprot id: G3RB98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9595:ESCO2
gene id: 9595:ESCO2
uniprot id: G3R2L3
names: Subcellular Location Annotation
messages: Nucleus

9595:BRF1
gene id: 9595:BRF1
uniprot id: G3QXB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIB family.
messages: Nucleus

9595:SFMBT2
gene id: 9595:SFMBT2
uniprot id: G3QI80
names: Subcellular Location Annotation
messages: Nucleus

9595:HPS5
gene id: 9595:HPS5
uniprot id: G3RTU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9595:TAF7L
gene id: 9595:TAF7L
uniprot id: G3QP91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9595:PERP
gene id: 9595:PERP
uniprot id: A0A2I2Y8U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9595:DDX49
gene id: 9595:DDX49
uniprot id: A0A2I2ZVB8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9595:STAT6
gene id: 9595:STAT6
uniprot id: G3QGF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9595:LOC101150282
gene id: 9595:LOC101150282
uniprot id: G3SCE6
names: Subcellular Location Annotation
messages: Membrane

9595:PIGW
gene id: 9595:PIGW
uniprot id: G3QY46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

9595:BLOC1S6
gene id: 9595:BLOC1S6
uniprot id: G3RDE4
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9595:TERF2IP
gene id: 9595:TERF2IP
uniprot id: G3SE84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9595:POMK
gene id: 9595:POMK
uniprot id: G3RLH7
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

9595:IFI27L1
gene id: 9595:IFI27L1
uniprot id: A0A2I2YU41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9595:MPI
gene id: 9595:MPI
uniprot id: A0A2I2Z5A4
uniprot id: G3RFM0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9595:AP4B1
gene id: 9595:AP4B1
uniprot id: A0A2I2YYV2
uniprot id: G3R6Z0
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9595:ARMT1
gene id: 9595:ARMT1
uniprot id: G3S2Y4
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9595:RRAGA
gene id: 9595:RRAGA
uniprot id: G3S7I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9595:NODAL
gene id: 9595:NODAL
uniprot id: G3QJE8
names: Similarity
messages: Belongs to the TGF-beta family.

9595:GAL3ST1
gene id: 9595:GAL3ST1
uniprot id: G3R2Y3
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9595:LOC101129229
gene id: 9595:LOC101129229
uniprot id: G3S988
names: Subcellular Location Annotation
messages: Membrane

9595:ST3GAL2
gene id: 9595:ST3GAL2
uniprot id: G3R0D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:SPAM1
gene id: 9595:SPAM1
uniprot id: A0A2I2ZU03
uniprot id: G3QVL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9595:ADAM23
gene id: 9595:ADAM23
uniprot id: A0A2I2YGG8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101150759
gene id: 9595:LOC101150759
uniprot id: A0A2I2ZAL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PI4K2B
gene id: 9595:PI4K2B
uniprot id: G3RDX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9595:LOC101153683
gene id: 9595:LOC101153683
uniprot id: G3RSY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CEP19
gene id: 9595:CEP19
uniprot id: G3S8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9595:SPESP1
gene id: 9595:SPESP1
uniprot id: G3RCT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPESP1 family.
messages: Involved in fertilization ability of sperm.
messages: acrosome

9595:PNP
gene id: 9595:PNP
uniprot id: G3SH63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9595:TNFRSF25
gene id: 9595:TNFRSF25
uniprot id: A0A2I2YXM2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:E2F7
gene id: 9595:E2F7
uniprot id: G3RA82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:TAS2R40
gene id: 9595:TAS2R40
uniprot id: G3RK90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:SLC35B3
gene id: 9595:SLC35B3
uniprot id: G3R794
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9595:ACADS
gene id: 9595:ACADS
uniprot id: A0A2I2Z339
uniprot id: G3QI49
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9595:TSPO2
gene id: 9595:TSPO2
uniprot id: G3R8R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9595:MDK
gene id: 9595:MDK
uniprot id: G3S2W7
names: Similarity
messages: Belongs to the pleiotrophin family.

9595:MAPK8
gene id: 9595:MAPK8
uniprot id: A0A2I2ZC90
uniprot id: A0A2I2ZPX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9595:REN
gene id: 9595:REN
uniprot id: G3SCD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Interacts with ATP6AP2.
messages: Membrane
messages: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

9595:MAPKAP1
gene id: 9595:MAPKAP1
uniprot id: A0A2I2Y7P7
uniprot id: A0A2I2YV76
uniprot id: G3QT17
uniprot id: G3RMW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIN1 family.
messages: Cytoplasmic vesicle

9595:YIPF5
gene id: 9595:YIPF5
uniprot id: G3RZC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9595:TNFRSF10A
gene id: 9595:TNFRSF10A
uniprot id: A0A2I2ZI00
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

9595:TLE6
gene id: 9595:TLE6
uniprot id: G3RFN3
names: Similarity
messages: Belongs to the WD repeat Groucho/TLE family.

9595:MCUR1
gene id: 9595:MCUR1
uniprot id: G3QJJ7
names: Similarity
messages: Belongs to the CCDC90 family.

9595:POGLUT2
gene id: 9595:POGLUT2
uniprot id: G3R624
names: Similarity
messages: Belongs to the KDELC family.

9595:MOGAT1
gene id: 9595:MOGAT1
uniprot id: G3R0J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9595:CKAP2L
gene id: 9595:CKAP2L
uniprot id: G3SK27
names: Similarity
messages: Belongs to the CKAP2 family.

9595:LYRM2
gene id: 9595:LYRM2
uniprot id: A0A2I2ZJ23
names: Similarity
messages: Belongs to the complex I LYR family.

9595:PSMB11
gene id: 9595:PSMB11
uniprot id: G3QWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:GCLC
gene id: 9595:GCLC
uniprot id: G3QV17
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9595:SERPINA3
gene id: 9595:SERPINA3
uniprot id: G3QEH5
names: Similarity
messages: Belongs to the serpin family.

9595:CXCL5
gene id: 9595:CXCL5
uniprot id: G3SIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:ZSCAN30
gene id: 9595:ZSCAN30
uniprot id: G3RWS5
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC39A14
gene id: 9595:SLC39A14
uniprot id: A0A2I2YLD7
uniprot id: G3QMF7
names: Subcellular Location Annotation
messages: Membrane

9595:EDC3
gene id: 9595:EDC3
uniprot id: G3QLW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9595:TMEM214
gene id: 9595:TMEM214
uniprot id: G3RL76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:HUWE1
gene id: 9595:HUWE1
uniprot id: A0A2I2ZC49
names: Similarity
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.

9595:VAMP1
gene id: 9595:VAMP1
uniprot id: A0A2I2Z5Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9595:TMEM132A
gene id: 9595:TMEM132A
uniprot id: G3QZZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9595:ARSI
gene id: 9595:ARSI
uniprot id: G3SBP0
names: Similarity
messages: Belongs to the sulfatase family.

9595:LOC101148899
gene id: 9595:LOC101148899
uniprot id: G3QSU3
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9595:SFXN5
gene id: 9595:SFXN5
uniprot id: G3QRA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9595:ATOSB
gene id: 9595:ATOSB
uniprot id: G3QL21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9595:CD5L
gene id: 9595:CD5L
uniprot id: G3R058
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:IFT43
gene id: 9595:IFT43
uniprot id: G3QGK5
names: Similarity
messages: Belongs to the IFT43 family.

9595:RWDD3
gene id: 9595:RWDD3
uniprot id: G3RYE8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:SIVA1
gene id: 9595:SIVA1
uniprot id: G3RB25
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

9595:IFT56
gene id: 9595:IFT56
uniprot id: G3QSE7
names: Similarity
messages: Belongs to the IFT56 family.

9595:GRIA1
gene id: 9595:GRIA1
uniprot id: A0A2I2YPI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9595:ATG4C
gene id: 9595:ATG4C
uniprot id: G3QWE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9595:RPS27A
gene id: 9595:RPS27A
uniprot id: G3RVB1
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

9595:CD46
gene id: 9595:CD46
uniprot id: A0A2I2Y6M3
uniprot id: G3QD59
uniprot id: G3RSH3
uniprot id: G3SGB2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

9595:PTS
gene id: 9595:PTS
uniprot id: A0A2I2YV86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9595:RPS19BP1
gene id: 9595:RPS19BP1
uniprot id: G3R3P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

9595:LOC101151556
gene id: 9595:LOC101151556
uniprot id: G3R5Y1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:NADK
gene id: 9595:NADK
uniprot id: G3RQZ2
names: Similarity
messages: Belongs to the NAD kinase family.

9595:MOGS
gene id: 9595:MOGS
uniprot id: A0A2I2YD12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9595:LOC101150151
gene id: 9595:LOC101150151
uniprot id: G3RDP1
names: Similarity
messages: Belongs to the LCE family.

9595:PARP16
gene id: 9595:PARP16
uniprot id: G3SBT9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:ZNF18
gene id: 9595:ZNF18
uniprot id: G3QRQ6
names: Subcellular Location Annotation
messages: Nucleus

9595:TRMT1
gene id: 9595:TRMT1
uniprot id: A0A2I2ZR82
uniprot id: G3RDQ8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

9595:LOC101124572
gene id: 9595:LOC101124572
uniprot id: G3S063
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:CETN2
gene id: 9595:CETN2
uniprot id: G3R6X2
names: Similarity
messages: Belongs to the centrin family.

9595:CCL1
gene id: 9595:CCL1
uniprot id: G3RRC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:HNRNPR
gene id: 9595:HNRNPR
uniprot id: G3SIJ9
names: Subcellular Location Annotation
messages: Cytoplasm

9595:SLC35C2
gene id: 9595:SLC35C2
uniprot id: A0A2I2ZAS0
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101141395
gene id: 9595:LOC101141395
uniprot id: G3QFY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Belongs to the MHC class II family.
messages: Endosome membrane
messages: Lysosome membrane

9595:ATG13
gene id: 9595:ATG13
uniprot id: A0A2I2Z9M8
uniprot id: G3QSD9
uniprot id: G3RZC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9595:PCSK1
gene id: 9595:PCSK1
uniprot id: G3QVR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9595:A2M
gene id: 9595:A2M
uniprot id: G3RD11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9595:ATXN1
gene id: 9595:ATXN1
uniprot id: G3QNH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9595:PKD2L2
gene id: 9595:PKD2L2
uniprot id: A0A2I2YNR7
uniprot id: G3R4D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

9595:SLC40A1
gene id: 9595:SLC40A1
uniprot id: A0A2I2ZHV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

9595:AADACL2
gene id: 9595:AADACL2
uniprot id: G3R0M5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9595:LOC101136913
gene id: 9595:LOC101136913
uniprot id: A0A2I2ZB54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SLC35B1
gene id: 9595:SLC35B1
uniprot id: G3RQ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9595:PGAP3
gene id: 9595:PGAP3
uniprot id: A0A2I2YFK6
uniprot id: A0A2I2ZIR1
uniprot id: G3SAB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LOC101132414
gene id: 9595:LOC101132414
uniprot id: G3RXM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:EIF4E1B
gene id: 9595:EIF4E1B
uniprot id: G3RMR3
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9595:PRSS16
gene id: 9595:PRSS16
uniprot id: G3R2M8
names: Similarity
messages: Belongs to the peptidase S28 family.

9595:SPACA5
gene id: 9595:SPACA5
uniprot id: G3SBU4
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9595:USP7
gene id: 9595:USP7
uniprot id: G3QRK0
names: Similarity
messages: Belongs to the peptidase C19 family.

9595:LOC101152957
gene id: 9595:LOC101152957
uniprot id: G3QD82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SLC27A3
gene id: 9595:SLC27A3
uniprot id: G3QMP1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:KRT23
gene id: 9595:KRT23
uniprot id: G3RNV9
names: Similarity
messages: Belongs to the intermediate filament family.

9595:PRNP
gene id: 9595:PRNP
uniprot id: P40252
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prion family.
messages: Cell membrane
messages: Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.
messages: Golgi apparatus
messages: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
messages: Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1 (By similarity). Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity). Interacts with APP. Interacts with KIAA1191 (By similarity). Interacts with ADGRG6 (By similarity).
messages: PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
messages: The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.

9595:MARCKSL1
gene id: 9595:MARCKSL1
uniprot id: G3R7W1
names: Similarity
messages: Belongs to the MARCKS family.

9595:CBX7
gene id: 9595:CBX7
uniprot id: G3QQA9
names: Subcellular Location Annotation
messages: Nucleus

9595:FAM114A2
gene id: 9595:FAM114A2
uniprot id: A0A2I2YE12
names: Similarity
messages: Belongs to the FAM114 family.

9595:TMEM19
gene id: 9595:TMEM19
uniprot id: G3RXQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9595:MRGPRX4
gene id: 9595:MRGPRX4
uniprot id: G3RK72
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:STEAP3
gene id: 9595:STEAP3
uniprot id: G3R8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9595:RPLP0
gene id: 9595:RPLP0
uniprot id: G3SDP0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9595:WDR44
gene id: 9595:WDR44
uniprot id: G3QL01
names: Subcellular Location Annotation
messages: trans-Golgi network

9595:LYZL2
gene id: 9595:LYZL2
uniprot id: G3SCD7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9595:MYH3
gene id: 9595:MYH3
uniprot id: G3QE77
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:NEU4
gene id: 9595:NEU4
uniprot id: G3REG3
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9595:SLC47A1
gene id: 9595:SLC47A1
uniprot id: G3S2U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9595:PCNA
gene id: 9595:PCNA
uniprot id: G3QH49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9595:SPTLC2
gene id: 9595:SPTLC2
uniprot id: G3R898
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9595:CCDC93
gene id: 9595:CCDC93
uniprot id: G3SJF9
names: Similarity
messages: Belongs to the CCDC93 family.

9595:LOC101126623
gene id: 9595:LOC101126623
uniprot id: G3RI90
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:PSMB6
gene id: 9595:PSMB6
uniprot id: G3R756
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:TMLHE
gene id: 9595:TMLHE
uniprot id: G3S446
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

9595:TH
gene id: 9595:TH
uniprot id: G3QN04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region
messages: synaptic vesicle

9595:TMEM178B
gene id: 9595:TMEM178B
uniprot id: A0A2I2Z5R3
names: Similarity
messages: Belongs to the TMEM178 family.

9595:HARS2
gene id: 9595:HARS2
uniprot id: G3RBJ9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9595:RRAGB
gene id: 9595:RRAGB
uniprot id: G3R786
uniprot id: G3S8V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9595:PHETA2
gene id: 9595:PHETA2
uniprot id: A0A2I2YH37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9595:IGF2
gene id: 9595:IGF2
uniprot id: A0A2I2YR49
uniprot id: A0A2I2ZL48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Secreted

9595:YIPF1
gene id: 9595:YIPF1
uniprot id: G3RHA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9595:SBF1
gene id: 9595:SBF1
uniprot id: A0A2I2ZMY5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9595:TM4SF5
gene id: 9595:TM4SF5
uniprot id: G3R744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9595:ERO1A
gene id: 9595:ERO1A
uniprot id: G3RTY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9595:A4GNT
gene id: 9595:A4GNT
uniprot id: G3QPH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9595:LOC101134050
gene id: 9595:LOC101134050
uniprot id: G3S9C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:VANGL2
gene id: 9595:VANGL2
uniprot id: G3RDQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9595:HABP4
gene id: 9595:HABP4
uniprot id: G3R9D8
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

9595:ME2
gene id: 9595:ME2
uniprot id: G3R5I4
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9595:CPA3
gene id: 9595:CPA3
uniprot id: G3S533
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:ELOVL5
gene id: 9595:ELOVL5
uniprot id: G3R6X9
uniprot id: G3S6X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

9595:MYORG
gene id: 9595:MYORG
uniprot id: G3QXJ4
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9595:SF3B5
gene id: 9595:SF3B5
uniprot id: G3QGQ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9595:LDHAL6A
gene id: 9595:LDHAL6A
uniprot id: A0A2I2Z7D8
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9595:FAM110D
gene id: 9595:FAM110D
uniprot id: G3QUM4
names: Similarity
messages: Belongs to the FAM110 family.

9595:CPVL
gene id: 9595:CPVL
uniprot id: G3R230
names: Similarity
messages: Belongs to the peptidase S10 family.

9595:TMBIM4
gene id: 9595:TMBIM4
uniprot id: A0A2I2YGH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9595:FADS1
gene id: 9595:FADS1
uniprot id: G3RA11
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:IRF7
gene id: 9595:IRF7
uniprot id: G3S813
names: Subcellular Location Annotation
messages: Nucleus

9595:TMEM256
gene id: 9595:TMEM256
uniprot id: G3QD08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9595:ITGA6
gene id: 9595:ITGA6
uniprot id: G3QXU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:ENTPD6
gene id: 9595:ENTPD6
uniprot id: G3RG09
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9595:AATF
gene id: 9595:AATF
uniprot id: G3SD86
names: Similarity
messages: Belongs to the AATF family.

9595:JAGN1
gene id: 9595:JAGN1
uniprot id: G3R3V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:IP6K1
gene id: 9595:IP6K1
uniprot id: G3R503
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9595:MFN1
gene id: 9595:MFN1
uniprot id: G3R1R7
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9595:NUP98
gene id: 9595:NUP98
uniprot id: G3SH93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

9595:BABAM1
gene id: 9595:BABAM1
uniprot id: G3QSM0
uniprot id: G3S649
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9595:MSMP
gene id: 9595:MSMP
uniprot id: G3QWQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9595:TMED5
gene id: 9595:TMED5
uniprot id: G3RJ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9595:HRH4
gene id: 9595:HRH4
uniprot id: G3QS38
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:CHMP5
gene id: 9595:CHMP5
uniprot id: G3RK77
names: Similarity
messages: Belongs to the SNF7 family.

9595:ADAMTS14
gene id: 9595:ADAMTS14
uniprot id: G3R9J1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:DOP1B
gene id: 9595:DOP1B
uniprot id: G3QMJ6
names: Similarity
messages: Belongs to the dopey family.

9595:GUK1
gene id: 9595:GUK1
uniprot id: A0A2I2YN43
uniprot id: G3RCK1
uniprot id: G3S7U3
names: Similarity
messages: Belongs to the guanylate kinase family.

9595:CHD6
gene id: 9595:CHD6
uniprot id: G3RBG1
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9595:AMOT
gene id: 9595:AMOT
uniprot id: G3R6B8
names: Similarity
messages: Belongs to the angiomotin family.

9595:MTAP
gene id: 9595:MTAP
uniprot id: A0A2I2ZHX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9595:NUDT19
gene id: 9595:NUDT19
uniprot id: G3QXQ6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9595:RPL26
gene id: 9595:RPL26
uniprot id: G3RMT1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9595:TGM5
gene id: 9595:TGM5
uniprot id: A0A2I2ZV85
uniprot id: G3QUL1
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9595:POU2F2
gene id: 9595:POU2F2
uniprot id: G3R671
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9595:COPB1
gene id: 9595:COPB1
uniprot id: G3S1L5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9595:CNTNAP1
gene id: 9595:CNTNAP1
uniprot id: G3QLG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: paranodal septate junction

9595:PRRX2
gene id: 9595:PRRX2
uniprot id: G3QE99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9595:LOC101126994
gene id: 9595:LOC101126994
uniprot id: A0A2I2ZRN8
uniprot id: G3QVP9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:DMRTB1
gene id: 9595:DMRTB1
uniprot id: G3S787
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9595:ALG5
gene id: 9595:ALG5
uniprot id: G3QKR3
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9595:PLA2G15
gene id: 9595:PLA2G15
uniprot id: G3QGS4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9595:STOM
gene id: 9595:STOM
uniprot id: A0A2I2ZIH3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9595:LOC101136730
gene id: 9595:LOC101136730
uniprot id: G3QFS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:HTN3
gene id: 9595:HTN3
uniprot id: A0A2I2YBS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

9595:PTGFR
gene id: 9595:PTGFR
uniprot id: G3REY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PRDM5
gene id: 9595:PRDM5
uniprot id: A0A2I2YGF8
uniprot id: A0A2I2ZNF0
names: Subcellular Location Annotation
messages: Nucleus

9595:YPEL3
gene id: 9595:YPEL3
uniprot id: G3RAX9
names: Similarity
messages: Belongs to the yippee family.

9595:NRN1
gene id: 9595:NRN1
uniprot id: G3QR76
names: Similarity
messages: Belongs to the neuritin family.

9595:MLH1
gene id: 9595:MLH1
uniprot id: G3RJQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9595:CCT3
gene id: 9595:CCT3
uniprot id: A0A2I2Z9P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9595:UBA5
gene id: 9595:UBA5
uniprot id: G3QTF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9595:CFHR5
gene id: 9595:CFHR5
uniprot id: G3QJ14
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SLC10A4
gene id: 9595:SLC10A4
uniprot id: G3QXD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9595:ATP2A2
gene id: 9595:ATP2A2
uniprot id: A0A2I2YDK6
uniprot id: A0A2I2YIY1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9595:KCNQ5
gene id: 9595:KCNQ5
uniprot id: G3SGQ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:LOC109024875
gene id: 9595:LOC109024875
uniprot id: G3S0J7
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9595:TRIM2
gene id: 9595:TRIM2
uniprot id: A0A2I2YQC4
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9595:SEPTIN2
gene id: 9595:SEPTIN2
uniprot id: G3QPK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9595:SUOX
gene id: 9595:SUOX
uniprot id: G3RXF0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Homodimer.
messages: Mitochondrion intermembrane space

9595:FXYD4
gene id: 9595:FXYD4
uniprot id: G3R5L8
names: Similarity
messages: Belongs to the FXYD family.

9595:CASP14
gene id: 9595:CASP14
uniprot id: G3QDU6
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:CDKL1
gene id: 9595:CDKL1
uniprot id: A0A2I2ZYD1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:NCOA1
gene id: 9595:NCOA1
uniprot id: G3R6P2
uniprot id: G3RV45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9595:CLEC12B
gene id: 9595:CLEC12B
uniprot id: G3R0F9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:CENPC
gene id: 9595:CENPC
uniprot id: G3R2W2
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

9595:ANPEP
gene id: 9595:ANPEP
uniprot id: G3QSE0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9595:SLC27A6
gene id: 9595:SLC27A6
uniprot id: G3RXT6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:AMDHD2
gene id: 9595:AMDHD2
uniprot id: G3RW11
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.
messages: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.

9595:STX12
gene id: 9595:STX12
uniprot id: A0A2I2ZJA2
names: Similarity
messages: Belongs to the syntaxin family.

9595:MASP2
gene id: 9595:MASP2
uniprot id: G3RH68
uniprot id: G3RUG1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CDC42
gene id: 9595:CDC42
uniprot id: A0A2I2Z2P0
uniprot id: A0A2I2Z7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

9595:RPL9
gene id: 9595:RPL9
uniprot id: G3SHM1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

9595:GRP
gene id: 9595:GRP
uniprot id: G3QJM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9595:CNNM2
gene id: 9595:CNNM2
uniprot id: A0A2I2Z6D9
uniprot id: G3RBR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9595:ZSCAN18
gene id: 9595:ZSCAN18
uniprot id: G3RYM1
names: Subcellular Location Annotation
messages: Nucleus

9595:PPP1R1B
gene id: 9595:PPP1R1B
uniprot id: G3QV38
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9595:RRH
gene id: 9595:RRH
uniprot id: G3RNE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:B4GALT1
gene id: 9595:B4GALT1
uniprot id: G3R175
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9595:SV2A
gene id: 9595:SV2A
uniprot id: G3QKD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9595:ANP32B
gene id: 9595:ANP32B
uniprot id: G3R7K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9595:GLIS1
gene id: 9595:GLIS1
uniprot id: A0A2I2Z8D6
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9595:CNN1
gene id: 9595:CNN1
uniprot id: A0A2I2Y792
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9595:LOC101129227
gene id: 9595:LOC101129227
uniprot id: A0A2I2ZQQ5
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:CSTF2
gene id: 9595:CSTF2
uniprot id: A0A2I2ZTJ9
uniprot id: G3RRQ9
names: Subcellular Location Annotation
messages: Nucleus

9595:CCNA2
gene id: 9595:CCNA2
uniprot id: G3QIC8
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9595:LOC101142537
gene id: 9595:LOC101142537
uniprot id: G3RSZ1
names: Similarity
messages: Belongs to the SSX family.

9595:BCAN
gene id: 9595:BCAN
uniprot id: G3S2H7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:HYAL1
gene id: 9595:HYAL1
uniprot id: A0A2I2ZQS0
uniprot id: G3QVZ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9595:IRX5
gene id: 9595:IRX5
uniprot id: G3S1Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9595:PES1
gene id: 9595:PES1
uniprot id: G3QZN0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

9595:GSTM4
gene id: 9595:GSTM4
uniprot id: A0A2I2Z385
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9595:ECH1
gene id: 9595:ECH1
uniprot id: G3QLW6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9595:PSMA7
gene id: 9595:PSMA7
uniprot id: G3QS87
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9595:STAG2
gene id: 9595:STAG2
uniprot id: G3QND0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9595:ACSL5
gene id: 9595:ACSL5
uniprot id: G3QPL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

9595:CCNDBP1
gene id: 9595:CCNDBP1
uniprot id: G3SIP2
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

9595:ABRAXAS1
gene id: 9595:ABRAXAS1
uniprot id: G3QSQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Nucleus

9595:DZIP1L
gene id: 9595:DZIP1L
uniprot id: G3R7B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

9595:DNAJB14
gene id: 9595:DNAJB14
uniprot id: G3QD47
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:CLIC5
gene id: 9595:CLIC5
uniprot id: G3SBW3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9595:DXO
gene id: 9595:DXO
uniprot id: G3QIM6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9595:RRP15
gene id: 9595:RRP15
uniprot id: G3RKD0
names: Similarity
messages: Belongs to the RRP15 family.

9595:LOC101126416
gene id: 9595:LOC101126416
uniprot id: G3SCM0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:RNPEP
gene id: 9595:RNPEP
uniprot id: G3RE55
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9595:ZNF706
gene id: 9595:ZNF706
uniprot id: A0A2I2Z9V7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:CASP7
gene id: 9595:CASP7
uniprot id: A0A2I2ZD95
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:TPPP2
gene id: 9595:TPPP2
uniprot id: A0A2I2YJM1
names: Similarity
messages: Belongs to the TPPP family.

9595:GJA10
gene id: 9595:GJA10
uniprot id: G3RDV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:NDST3
gene id: 9595:NDST3
uniprot id: G3SKG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9595:ANKRD34C
gene id: 9595:ANKRD34C
uniprot id: A0A2I2ZI35
names: Similarity
messages: Belongs to the ANKRD34 family.

9595:DBNDD2
gene id: 9595:DBNDD2
uniprot id: A0A2I2Z6B0
names: Similarity
messages: Belongs to the dysbindin family.

9595:MB
gene id: 9595:MB
uniprot id: G3R764
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9595:APCS
gene id: 9595:APCS
uniprot id: G3QGL3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9595:ING4
gene id: 9595:ING4
uniprot id: G3RIX2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9595:PALMD
gene id: 9595:PALMD
uniprot id: G3SE02
names: Similarity
messages: Belongs to the paralemmin family.

9595:HOXA1
gene id: 9595:HOXA1
uniprot id: G3QIG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9595:TNFRSF21
gene id: 9595:TNFRSF21
uniprot id: A0A2I2Z0W0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:UPF3B
gene id: 9595:UPF3B
uniprot id: G3RUF1
uniprot id: G3RVN9
names: Similarity
messages: Belongs to the RENT3 family.

9595:RAB18
gene id: 9595:RAB18
uniprot id: G3QYG9
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9595:ZSCAN4
gene id: 9595:ZSCAN4
uniprot id: G3QRD7
names: Subcellular Location Annotation
messages: Nucleus

9595:DHRS9
gene id: 9595:DHRS9
uniprot id: G3RCJ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:SYNCRIP
gene id: 9595:SYNCRIP
uniprot id: G3RAV5
names: Subcellular Location Annotation
messages: Cytoplasm

9595:DCTPP1
gene id: 9595:DCTPP1
uniprot id: G3RMI7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9595:PYROXD1
gene id: 9595:PYROXD1
uniprot id: A0A2I2Z7N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9595:EPHA5
gene id: 9595:EPHA5
uniprot id: A0A2I2ZLR6
uniprot id: G3RK16
names: Subcellular Location Annotation
messages: Membrane

9595:AWAT2
gene id: 9595:AWAT2
uniprot id: G3QSZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9595:URM1
gene id: 9595:URM1
uniprot id: A0A2I2YGW8
uniprot id: G3RFR8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9595:MED12L
gene id: 9595:MED12L
uniprot id: G3RHT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

9595:SNX25
gene id: 9595:SNX25
uniprot id: G3RLT7
names: Similarity
messages: Belongs to the sorting nexin family.

9595:CCDC126
gene id: 9595:CCDC126
uniprot id: G3S139
names: Subcellular Location Annotation
messages: Secreted

9595:EGFL6
gene id: 9595:EGFL6
uniprot id: G3RAM1
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:HSD17B3
gene id: 9595:HSD17B3
uniprot id: G3QK20
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:TNFSF12
gene id: 9595:TNFSF12
uniprot id: A0A2I2YXR1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9595:UBE2C
gene id: 9595:UBE2C
uniprot id: G3S6I6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:KCNH3
gene id: 9595:KCNH3
uniprot id: G3QGS8
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9595:LANCL2
gene id: 9595:LANCL2
uniprot id: G3RIV2
names: Similarity
messages: Belongs to the LanC-like protein family.

9595:IAPP
gene id: 9595:IAPP
uniprot id: G3RQX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

9595:LSM8
gene id: 9595:LSM8
uniprot id: A0A2I2YFG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9595:GNAT1
gene id: 9595:GNAT1
uniprot id: G3QZZ3
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9595:COPZ1
gene id: 9595:COPZ1
uniprot id: G3QZ23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9595:ITGA1
gene id: 9595:ITGA1
uniprot id: G3RPX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:TERT
gene id: 9595:TERT
uniprot id: G3RW38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
messages: The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity.
messages: The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.
messages: The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.
messages: nucleolus
messages: nucleoplasm
messages: telomere

9595:FTMT
gene id: 9595:FTMT
uniprot id: G3QGN1
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9595:BMT2
gene id: 9595:BMT2
uniprot id: G3S2J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9595:GJB6
gene id: 9595:GJB6
uniprot id: G3QPV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:AGO1
gene id: 9595:AGO1
uniprot id: G3QLB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9595:EGFL8
gene id: 9595:EGFL8
uniprot id: G3QIR3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:HABP2
gene id: 9595:HABP2
uniprot id: G3QIP4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:GPT2
gene id: 9595:GPT2
uniprot id: G3RJK4
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9595:TSEN15
gene id: 9595:TSEN15
uniprot id: A0A2I2ZQX4
uniprot id: G3RIB6
names: Similarity
messages: Belongs to the SEN15 family.

9595:AGPAT1
gene id: 9595:AGPAT1
uniprot id: G3RMU5
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9595:BVES
gene id: 9595:BVES
uniprot id: G3RSB1
names: Similarity
messages: Belongs to the popeye family.

9595:DCN
gene id: 9595:DCN
uniprot id: A0A2I2Y4I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

9595:B4GALNT1
gene id: 9595:B4GALNT1
uniprot id: G3QTX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:HMGB2
gene id: 9595:HMGB2
uniprot id: G3RII6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9595:LOC101141762
gene id: 9595:LOC101141762
uniprot id: G3QND7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9595:TMEM107
gene id: 9595:TMEM107
uniprot id: A0A2I2ZAN6
names: Subcellular Location Annotation
messages: Membrane

9595:CCDC86
gene id: 9595:CCDC86
uniprot id: G3RCU9
names: Subcellular Location Annotation
messages: Nucleus

9595:ATXN3
gene id: 9595:ATXN3
uniprot id: A0A2I2YJG1
uniprot id: A0A2I2ZJ77
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:KDELR3
gene id: 9595:KDELR3
uniprot id: G3QZ17
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SYNJ1
gene id: 9595:SYNJ1
uniprot id: A0A2I2Y500
uniprot id: G3RIQ1
uniprot id: G3RU85
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9595:TRIM71
gene id: 9595:TRIM71
uniprot id: G3RLQ5
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9595:LTA4H
gene id: 9595:LTA4H
uniprot id: G3QVH4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9595:AR
gene id: 9595:AR
uniprot id: A0A2I2YGE1
names: Similarity
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.

9595:RNPS1
gene id: 9595:RNPS1
uniprot id: A0A2I2ZM53
uniprot id: G3SFX8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus speckle

9595:CPB1
gene id: 9595:CPB1
uniprot id: G3QRF4
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:LOC101150037
gene id: 9595:LOC101150037
uniprot id: G3RU27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:RHOT1
gene id: 9595:RHOT1
uniprot id: A0A2I2YSS3
uniprot id: A0A2I2ZEP6
uniprot id: G3SDU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9595:ALG14
gene id: 9595:ALG14
uniprot id: G3QQ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

9595:SLC29A1
gene id: 9595:SLC29A1
uniprot id: G3QZ84
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9595:CXXC1
gene id: 9595:CXXC1
uniprot id: G3RLC7
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101146118
gene id: 9595:LOC101146118
uniprot id: A0A2I2Y5S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:DOK5
gene id: 9595:DOK5
uniprot id: G3RW59
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9595:SHQ1
gene id: 9595:SHQ1
uniprot id: G3SKQ5
names: Similarity
messages: Belongs to the SHQ1 family.

9595:DYNC1I2
gene id: 9595:DYNC1I2
uniprot id: A0A2I2YA06
uniprot id: A0A2I2Z8V6
uniprot id: G3QJQ7
uniprot id: G3SFG3
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9595:MTRF1L
gene id: 9595:MTRF1L
uniprot id: G3SCN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9595:CLDN9
gene id: 9595:CLDN9
uniprot id: A0A2I2Z2C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:HSF5
gene id: 9595:HSF5
uniprot id: G3RD56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9595:SLC16A14
gene id: 9595:SLC16A14
uniprot id: G3QIK8
names: Subcellular Location Annotation
messages: Membrane

9595:MARVELD1
gene id: 9595:MARVELD1
uniprot id: G3SIG2
names: Subcellular Location Annotation
messages: Membrane

9595:TAF11
gene id: 9595:TAF11
uniprot id: A0A2I2ZH01
uniprot id: G3R9I8
names: Similarity
messages: Belongs to the TAF11 family.

9595:HAL
gene id: 9595:HAL
uniprot id: A0A2I2YY58
uniprot id: G3QVF7
names: Similarity
messages: Belongs to the PAL/histidase family.

9595:CPLX4
gene id: 9595:CPLX4
uniprot id: G3QV41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9595:PYGL
gene id: 9595:PYGL
uniprot id: G3RNK3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9595:CAVIN3
gene id: 9595:CAVIN3
uniprot id: G3R2A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9595:LOC101147010
gene id: 9595:LOC101147010
uniprot id: A0A2I2YBG8
uniprot id: G3S3P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9595:SIGMAR1
gene id: 9595:SIGMAR1
uniprot id: G3QKA2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle
messages: growth cone

9595:CXCR2
gene id: 9595:CXCR2
uniprot id: G3R144
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:COG2
gene id: 9595:COG2
uniprot id: G3R4J5
names: Similarity
messages: Belongs to the COG2 family.

9595:GPR68
gene id: 9595:GPR68
uniprot id: G3S4M3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:SEZ6
gene id: 9595:SEZ6
uniprot id: G3R9H9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LSM3
gene id: 9595:LSM3
uniprot id: G3R3E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9595:ASZ1
gene id: 9595:ASZ1
uniprot id: Q2IBF5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

9595:LCA5
gene id: 9595:LCA5
uniprot id: G3QXC4
names: Similarity
messages: Belongs to the LCA5 family.

9595:CUL9
gene id: 9595:CUL9
uniprot id: G3QS70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9595:PGM1
gene id: 9595:PGM1
uniprot id: G3RIU8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9595:ATXN1L
gene id: 9595:ATXN1L
uniprot id: A0A2I2ZDV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9595:GABRR3
gene id: 9595:GABRR3
uniprot id: G3R834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:RNASE9
gene id: 9595:RNASE9
uniprot id: Q863K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Does not exhibit any ribonuclease activity.
messages: Secreted

9595:FOXM1
gene id: 9595:FOXM1
uniprot id: G3R1V7
uniprot id: G3SAZ9
names: Subcellular Location Annotation
messages: Nucleus

9595:SEMA5B
gene id: 9595:SEMA5B
uniprot id: G3QXA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SLC6A7
gene id: 9595:SLC6A7
uniprot id: G3QD03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:LOC101138267
gene id: 9595:LOC101138267
uniprot id: G3RGC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CORO2B
gene id: 9595:CORO2B
uniprot id: G3RB93
names: Similarity
messages: Belongs to the WD repeat coronin family.

9595:HNRNPAB
gene id: 9595:HNRNPAB
uniprot id: A0A2I2ZXJ6
uniprot id: G3R7R0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:B4GALT6
gene id: 9595:B4GALT6
uniprot id: G3QLQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9595:SLC25A53
gene id: 9595:SLC25A53
uniprot id: G3RJ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:POLR3K
gene id: 9595:POLR3K
uniprot id: G3QZI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9595:HIF3A
gene id: 9595:HIF3A
uniprot id: A0A2I2YER8
uniprot id: A0A2I2ZDX2
uniprot id: A0A2I2ZWC7
names: Subcellular Location Annotation
messages: Nucleus speckle

9595:PNCK
gene id: 9595:PNCK
uniprot id: G3QS15
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:TAF13
gene id: 9595:TAF13
uniprot id: G3R267
names: Subcellular Location Annotation
messages: Nucleus

9595:GALNT18
gene id: 9595:GALNT18
uniprot id: G3QS74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:KAT5
gene id: 9595:KAT5
uniprot id: A0A2I2ZJT3
uniprot id: G3S5C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9595:PDCD11
gene id: 9595:PDCD11
uniprot id: G3R7L4
names: Subcellular Location Annotation
messages: nucleolus

9595:EOMES
gene id: 9595:EOMES
uniprot id: G3QZ67
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:RPS23
gene id: 9595:RPS23
uniprot id: A0A2I2ZQV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Rough endoplasmic reticulum

9595:MT4
gene id: 9595:MT4
uniprot id: G3QR55
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:SRD5A3
gene id: 9595:SRD5A3
uniprot id: G3SAM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9595:E2F3
gene id: 9595:E2F3
uniprot id: G3SFQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:GANAB
gene id: 9595:GANAB
uniprot id: A0A2I2Y4E6
uniprot id: G3RCQ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9595:BLCAP
gene id: 9595:BLCAP
uniprot id: G3S7R5
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

9595:PRPSAP2
gene id: 9595:PRPSAP2
uniprot id: G3RH64
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9595:ADGRF1
gene id: 9595:ADGRF1
uniprot id: G3SEQ2
names: Subcellular Location Annotation
messages: Membrane

9595:TTYH1
gene id: 9595:TTYH1
uniprot id: G3QQZ4
uniprot id: G3RQL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9595:SAMD8
gene id: 9595:SAMD8
uniprot id: A0A2I2YQC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9595:GPR183
gene id: 9595:GPR183
uniprot id: G3QEL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MTERF2
gene id: 9595:MTERF2
uniprot id: G3RX35
names: Similarity
messages: Belongs to the mTERF family.

9595:VPS33A
gene id: 9595:VPS33A
uniprot id: G3QRJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9595:HSPA8
gene id: 9595:HSPA8
uniprot id: G3RYM8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9595:TNS4
gene id: 9595:TNS4
uniprot id: G3R2K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9595:DCLRE1A
gene id: 9595:DCLRE1A
uniprot id: G3SF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9595:ZSCAN23
gene id: 9595:ZSCAN23
uniprot id: G3RNB1
names: Subcellular Location Annotation
messages: Nucleus

9595:TMEM33
gene id: 9595:TMEM33
uniprot id: G3R183
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9595:IL2RB
gene id: 9595:IL2RB
uniprot id: G3QIL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.

9595:LOC101140204
gene id: 9595:LOC101140204
uniprot id: A0A2I2YNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane

9595:HMGCL
gene id: 9595:HMGCL
uniprot id: G3QNX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9595:GALC
gene id: 9595:GALC
uniprot id: G3RPY6
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

9595:ELP5
gene id: 9595:ELP5
uniprot id: G3S9D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9595:CHST7
gene id: 9595:CHST7
uniprot id: G3S3P2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:LOC101150168
gene id: 9595:LOC101150168
uniprot id: G3RQF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9595:ST8SIA5
gene id: 9595:ST8SIA5
uniprot id: G3RD61
uniprot id: G3S807
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:TSEN2
gene id: 9595:TSEN2
uniprot id: G3R9T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9595:EGFLAM
gene id: 9595:EGFLAM
uniprot id: A0A2I2YML9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:GPBP1
gene id: 9595:GPBP1
uniprot id: G3QZA0
uniprot id: G3S8V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9595:LOC101142418
gene id: 9595:LOC101142418
uniprot id: G3RC58
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:DDX43
gene id: 9595:DDX43
uniprot id: G3S041
names: Similarity
messages: Belongs to the DEAD box helicase family.

9595:ADCYAP1R1
gene id: 9595:ADCYAP1R1
uniprot id: A0A2I2ZBZ5
uniprot id: A0A2I2ZHJ5
uniprot id: A0A2I2ZLK4
names: Subcellular Location Annotation
messages: Membrane

9595:EHD4
gene id: 9595:EHD4
uniprot id: G3R825
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9595:PSD2
gene id: 9595:PSD2
uniprot id: G3S018
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9595:FUS
gene id: 9595:FUS
uniprot id: G3RPN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9595:TJP2
gene id: 9595:TJP2
uniprot id: A0A2I2ZAR7
uniprot id: A0A2I2ZAW3
uniprot id: A0A2I2ZVU8
uniprot id: G3SE59
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9595:SLC37A2
gene id: 9595:SLC37A2
uniprot id: G3RHQ0
uniprot id: G3RTK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9595:NF2
gene id: 9595:NF2
uniprot id: A0A2I2YM46
uniprot id: A0A2I2YZG5
uniprot id: A0A2I2ZFQ4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9595:KCNA5
gene id: 9595:KCNA5
uniprot id: G3R8M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

9595:N4BP3
gene id: 9595:N4BP3
uniprot id: G3QCR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Vesicle
messages: dendrite

9595:PHOSPHO1
gene id: 9595:PHOSPHO1
uniprot id: G3QHU0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9595:LOC101148603
gene id: 9595:LOC101148603
uniprot id: G3RK00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:GTPBP4
gene id: 9595:GTPBP4
uniprot id: G3RC29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9595:MPV17L2
gene id: 9595:MPV17L2
uniprot id: G3R0J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9595:STYXL2
gene id: 9595:STYXL2
uniprot id: G3QPE2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9595:ACSL4
gene id: 9595:ACSL4
uniprot id: A0A2I2Y442
uniprot id: G3QZV5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:CDC25C
gene id: 9595:CDC25C
uniprot id: G3QEW4
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9595:CNDP1
gene id: 9595:CNDP1
uniprot id: A0A2I2Z7W3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9595:FOXJ1
gene id: 9595:FOXJ1
uniprot id: G3QWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FOXJ1 family.
messages: Nucleus

9595:BNIP3
gene id: 9595:BNIP3
uniprot id: G3RF13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9595:FAM166C
gene id: 9595:FAM166C
uniprot id: G3R576
names: Similarity
messages: Belongs to the CIMIP2 family.

9595:LOC101148853
gene id: 9595:LOC101148853
uniprot id: A0A2I2YM80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9595:NDUFA10
gene id: 9595:NDUFA10
uniprot id: Q0MQB6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Binds 1 FAD per subunit.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix
messages: Phosphorylation at Ser-250 by PINK1 is required for the binding and/or reduction of the complex I substrate ubiquinone.

9595:CA7
gene id: 9595:CA7
uniprot id: A0A2I2ZVT0
uniprot id: G3RF47
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9595:DPAGT1
gene id: 9595:DPAGT1
uniprot id: G3QYF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:SLC6A20
gene id: 9595:SLC6A20
uniprot id: G3QI65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:ASB6
gene id: 9595:ASB6
uniprot id: G3QJN5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:RPS12
gene id: 9595:RPS12
uniprot id: G3R953
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9595:CALB1
gene id: 9595:CALB1
uniprot id: G3QQH3
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

9595:BMP3
gene id: 9595:BMP3
uniprot id: G3QR41
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9595:CMTM5
gene id: 9595:CMTM5
uniprot id: A0A2I2Y6F2
uniprot id: G3S5C1
names: Subcellular Location Annotation
messages: Membrane

9595:NUDT3
gene id: 9595:NUDT3
uniprot id: A0A2I2ZRG2
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9595:HSPB7
gene id: 9595:HSPB7
uniprot id: G3QY36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9595:GDPD1
gene id: 9595:GDPD1
uniprot id: A0A2I2YEU8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9595:ADD2
gene id: 9595:ADD2
uniprot id: A0A2I2YDZ2
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9595:HBP1
gene id: 9595:HBP1
uniprot id: G3QXR1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9595:LOC101144524
gene id: 9595:LOC101144524
uniprot id: G3QT78
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9595:CREBBP
gene id: 9595:CREBBP
uniprot id: A0A2I2YD30
names: Subcellular Location Annotation
messages: Cytoplasm

9595:NIPA2
gene id: 9595:NIPA2
uniprot id: A0A2I2Y571
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9595:ETV3L
gene id: 9595:ETV3L
uniprot id: G3QIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:LOC101137537
gene id: 9595:LOC101137537
uniprot id: G3QKH6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9595:FCN2
gene id: 9595:FCN2
uniprot id: G3SI20
names: Similarity
messages: Belongs to the ficolin lectin family.

9595:MIS12
gene id: 9595:MIS12
uniprot id: G3R4Z8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9595:F13B
gene id: 9595:F13B
uniprot id: G3RK04
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SRPRA
gene id: 9595:SRPRA
uniprot id: G3RB09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:SIRT2
gene id: 9595:SIRT2
uniprot id: G3QJ69
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

9595:RAD52
gene id: 9595:RAD52
uniprot id: G3QUD4
names: Similarity
messages: Belongs to the RAD52 family.

9595:PACSIN1
gene id: 9595:PACSIN1
uniprot id: G3RRV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9595:THEMIS
gene id: 9595:THEMIS
uniprot id: G3RI95
names: Similarity
messages: Belongs to the themis family.

9595:AP1S2
gene id: 9595:AP1S2
uniprot id: A0A2I2YN18
uniprot id: A0A2I2ZIX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9595:LOC101134278
gene id: 9595:LOC101134278
uniprot id: A0A2I2ZN71
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:CRHBP
gene id: 9595:CRHBP
uniprot id: A0A2I2YML7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9595:LOC101137284
gene id: 9595:LOC101137284
uniprot id: G3S2U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PRKD3
gene id: 9595:PRKD3
uniprot id: G3RL70
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9595:SLC6A6
gene id: 9595:SLC6A6
uniprot id: A0A2I2ZC31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

9595:PQBP1
gene id: 9595:PQBP1
uniprot id: A1YFA7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic granule
messages: Except for the WW domain, the protein is intrinsically disordered.
messages: Interacts with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. Interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. Forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. Interacts (via C-terminus) with TXNL4A and CD2BP2. Interacts (via WW domain) with ATN1 and SF3B1, and may interact with additional splice factors. Interacts (via WW domain) with WBP11; Leading to reduce interaction between PQBP1 and TXNL4A. Interacts with CAPRIN1. Interacts with DDX1. Interacts with SFPQ. Interacts with KHSRP.
messages: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production.
messages: Nucleus
messages: Nucleus speckle
messages: The WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with WBP11, ATN1, SF3B1 and the C-terminal domain of the RNA polymerase II large subunit.

9595:LOC101143299
gene id: 9595:LOC101143299
uniprot id: G3R7E3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9595:PIGM
gene id: 9595:PIGM
uniprot id: G3S4N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9595:UBE2L6
gene id: 9595:UBE2L6
uniprot id: G3QR90
uniprot id: G3SCR6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:HNRNPDL
gene id: 9595:HNRNPDL
uniprot id: G3QMB5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:TSC22D1
gene id: 9595:TSC22D1
uniprot id: A0A2I2ZLV8
uniprot id: G3RAR2
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9595:PDSS1
gene id: 9595:PDSS1
uniprot id: G3R7M7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9595:F2R
gene id: 9595:F2R
uniprot id: G3R4I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ENO1
gene id: 9595:ENO1
uniprot id: G3R4B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9595:FGG
gene id: 9595:FGG
uniprot id: A0A2I2YC21
uniprot id: G3R8D4
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9595:MLLT3
gene id: 9595:MLLT3
uniprot id: G3QPC5
uniprot id: G3RWF8
names: Subcellular Location Annotation
messages: Nucleus

9595:GADD45A
gene id: 9595:GADD45A
uniprot id: G3R5D8
names: Similarity
messages: Belongs to the GADD45 family.

9595:CENPS
gene id: 9595:CENPS
uniprot id: G3RAC8
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

9595:MYOF
gene id: 9595:MYOF
uniprot id: G3RT91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9595:ELP2
gene id: 9595:ELP2
uniprot id: G3RMC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

9595:SLC25A35
gene id: 9595:SLC25A35
uniprot id: G3R668
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:BDH1
gene id: 9595:BDH1
uniprot id: G3R6E1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:MMP1
gene id: 9595:MMP1
uniprot id: G3R0I7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:GIMAP7
gene id: 9595:GIMAP7
uniprot id: G3QIU4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9595:SEC24A
gene id: 9595:SEC24A
uniprot id: A0A2I2ZV96
uniprot id: G3R641
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9595:CLDN17
gene id: 9595:CLDN17
uniprot id: G3QFD9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:MTERF1
gene id: 9595:MTERF1
uniprot id: A0A2I2ZHH1
names: Similarity
messages: Belongs to the mTERF family.

9595:FAM13C
gene id: 9595:FAM13C
uniprot id: A0A2I2ZS22
uniprot id: G3RTH3
names: Similarity
messages: Belongs to the FAM13 family.

9595:JUNB
gene id: 9595:JUNB
uniprot id: A0A2I2ZDY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9595:RRP1B
gene id: 9595:RRP1B
uniprot id: G3R8R6
names: Similarity
messages: Belongs to the RRP1 family.

9595:TMPRSS6
gene id: 9595:TMPRSS6
uniprot id: A0A2I2ZQU0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:PIP4P1
gene id: 9595:PIP4P1
uniprot id: G3QI92
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9595:E2F1
gene id: 9595:E2F1
uniprot id: G3QM04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9595:MVP
gene id: 9595:MVP
uniprot id: G3RHU8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9595:MRPS24
gene id: 9595:MRPS24
uniprot id: G3QSD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9595:NDUFS8
gene id: 9595:NDUFS8
uniprot id: Q0MQI2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Interacts with RAB5IF (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity).
messages: Mitochondrion inner membrane

9595:ADIPOR1
gene id: 9595:ADIPOR1
uniprot id: G3QQZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:PTAFR
gene id: 9595:PTAFR
uniprot id: G3REF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9595:PDHA2
gene id: 9595:PDHA2
uniprot id: G3RD19
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9595:MAPK7
gene id: 9595:MAPK7
uniprot id: G3QTA1
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9595:CCT7
gene id: 9595:CCT7
uniprot id: G3QXP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9595:FGR
gene id: 9595:FGR
uniprot id: G3QER4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9595:TMEM200A
gene id: 9595:TMEM200A
uniprot id: G3RBN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9595:CNFN
gene id: 9595:CNFN
uniprot id: G3QEP9
names: Similarity
messages: Belongs to the cornifelin family.

9595:EGR3
gene id: 9595:EGR3
uniprot id: G3QJ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9595:TBR1
gene id: 9595:TBR1
uniprot id: G3RS35
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:CDC42EP2
gene id: 9595:CDC42EP2
uniprot id: A0A2I2ZUQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9595:SETDB1
gene id: 9595:SETDB1
uniprot id: G3RJM2
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9595:KCNK16
gene id: 9595:KCNK16
uniprot id: G3QXC1
uniprot id: G3SGQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:SRD5A1
gene id: 9595:SRD5A1
uniprot id: G3RKC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9595:ARL8A
gene id: 9595:ARL8A
uniprot id: G3S521
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: axon
messages: spindle

9595:TPMT
gene id: 9595:TPMT
uniprot id: Q3BCR3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9595:GLRA3
gene id: 9595:GLRA3
uniprot id: G3QU31
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9595:ATP6V1F
gene id: 9595:ATP6V1F
uniprot id: G3RZ22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:ALDH1A3
gene id: 9595:ALDH1A3
uniprot id: G3QCV7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:FGD1
gene id: 9595:FGD1
uniprot id: G3QY89
names: Subcellular Location Annotation
messages: cytoskeleton

9595:ERCC2
gene id: 9595:ERCC2
uniprot id: A0A2I2ZV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

9595:HLF
gene id: 9595:HLF
uniprot id: G3QTC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9595:TRHDE
gene id: 9595:TRHDE
uniprot id: G3R602
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9595:P2RY13
gene id: 9595:P2RY13
uniprot id: G3REZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOXL1
gene id: 9595:LOXL1
uniprot id: G3RFS3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9595:SERINC3
gene id: 9595:SERINC3
uniprot id: G3RHA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9595:PRR15
gene id: 9595:PRR15
uniprot id: A0A2I2YZD5
names: Similarity
messages: Belongs to the PRR15 family.

9595:LOC101142172
gene id: 9595:LOC101142172
uniprot id: G3SGI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SETDB2
gene id: 9595:SETDB2
uniprot id: G3S799
names: Subcellular Location Annotation
messages: Chromosome

9595:HKDC1
gene id: 9595:HKDC1
uniprot id: G3R9K6
names: Similarity
messages: Belongs to the hexokinase family.

9595:MRPS33
gene id: 9595:MRPS33
uniprot id: G3R292
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9595:CEP63
gene id: 9595:CEP63
uniprot id: A0A2I2YUF7
uniprot id: A0A2I2Z5Q1
uniprot id: A0A2I2Z6P4
names: Similarity
messages: Belongs to the CEP63 family.

9595:RASSF1
gene id: 9595:RASSF1
uniprot id: G3QW11
names: Subcellular Location Annotation
messages: cytoskeleton

9595:USP39
gene id: 9595:USP39
uniprot id: G3QGA8
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC24A5
gene id: 9595:SLC24A5
uniprot id: G3RGP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9595:TAS2R7
gene id: 9595:TAS2R7
uniprot id: G3S7B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:PROK1
gene id: 9595:PROK1
uniprot id: G3QZB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9595:MYD88
gene id: 9595:MYD88
uniprot id: B3Y680
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
messages: Cytoplasm
messages: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, TLR5, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1. Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct.Interacts with OTUD4 deubiquitinase; the interaction is direct.
messages: Nucleus
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
messages: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.

9595:SLC35A5
gene id: 9595:SLC35A5
uniprot id: G3SGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:TCTN2
gene id: 9595:TCTN2
uniprot id: A0A2I2Z6V2
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9595:CENPK
gene id: 9595:CENPK
uniprot id: G3QQX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9595:DNMBP
gene id: 9595:DNMBP
uniprot id: A0A2I2Z4Z2
names: Subcellular Location Annotation
messages: Cell junction
messages: Golgi stack

9595:LLGL1
gene id: 9595:LLGL1
uniprot id: G3QKN5
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

9595:HSDL2
gene id: 9595:HSDL2
uniprot id: G3S6V2
names: Subcellular Location Annotation
messages: Peroxisome

9595:SLC25A4
gene id: 9595:SLC25A4
uniprot id: A0A2I2YVC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9595:SPIN4
gene id: 9595:SPIN4
uniprot id: G3QJS7
names: Similarity
messages: Belongs to the SPIN/STSY family.

9595:BOD1L2
gene id: 9595:BOD1L2
uniprot id: G3S6W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

9595:IL13RA1
gene id: 9595:IL13RA1
uniprot id: G3RFC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.
messages: Membrane

9595:EPHA1
gene id: 9595:EPHA1
uniprot id: G3QCY0
names: Subcellular Location Annotation
messages: Membrane

9595:SLC25A5
gene id: 9595:SLC25A5
uniprot id: G3REE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9595:TONSL
gene id: 9595:TONSL
uniprot id: G3RJF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

9595:PMPCA
gene id: 9595:PMPCA
uniprot id: G3R5R1
names: Similarity
messages: Belongs to the peptidase M16 family.

9595:PPAT
gene id: 9595:PPAT
uniprot id: G3QPM3
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9595:LOC101139006
gene id: 9595:LOC101139006
uniprot id: G3QG82
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101138014
gene id: 9595:LOC101138014
uniprot id: G3RV10
names: Subcellular Location Annotation
messages: Membrane

9595:DCLK1
gene id: 9595:DCLK1
uniprot id: A0A2I2Y344
uniprot id: G3QUA9
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9595:CLIC3
gene id: 9595:CLIC3
uniprot id: G3R7M3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9595:MED26
gene id: 9595:MED26
uniprot id: G3S035
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

9595:GYS2
gene id: 9595:GYS2
uniprot id: G3QU91
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9595:ARMC9
gene id: 9595:ARMC9
uniprot id: G3QJE1
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.
messages: centriole
messages: cilium
messages: cilium basal body

9595:NES
gene id: 9595:NES
uniprot id: G3S250
names: Similarity
messages: Belongs to the intermediate filament family.

9595:AKIRIN1
gene id: 9595:AKIRIN1
uniprot id: G3QTA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9595:POLE2
gene id: 9595:POLE2
uniprot id: G3RX47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

9595:KHDRBS1
gene id: 9595:KHDRBS1
uniprot id: G3QZW8
names: Similarity
messages: Belongs to the KHDRBS family.

9595:PSMC1
gene id: 9595:PSMC1
uniprot id: G3R4Z3
names: Similarity
messages: Belongs to the AAA ATPase family.

9595:TLX1
gene id: 9595:TLX1
uniprot id: G3S1Q9
names: Subcellular Location Annotation
messages: Nucleus

9595:SEMA7A
gene id: 9595:SEMA7A
uniprot id: G3QUI5
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ACTN2
gene id: 9595:ACTN2
uniprot id: A0A2I2ZV52
uniprot id: G3R8C5
names: Similarity
messages: Belongs to the alpha-actinin family.

9595:TMEM267
gene id: 9595:TMEM267
uniprot id: G3QQB7
names: Subcellular Location Annotation
messages: Membrane

9595:NLGN4X
gene id: 9595:NLGN4X
uniprot id: G3S197
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9595:VCAM1
gene id: 9595:VCAM1
uniprot id: G3QL75
names: Subcellular Location Annotation
messages: Cell membrane

9595:CSE1L
gene id: 9595:CSE1L
uniprot id: G3SCL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9595:BAK1
gene id: 9595:BAK1
uniprot id: G3RSX3
names: Similarity
messages: Belongs to the Bcl-2 family.

9595:CCDC124
gene id: 9595:CCDC124
uniprot id: G3QP06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC124 family.
messages: Midbody

9595:ATP4B
gene id: 9595:ATP4B
uniprot id: G3R8V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9595:CEBPB
gene id: 9595:CEBPB
uniprot id: A0A2I2ZBE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9595:KIF24
gene id: 9595:KIF24
uniprot id: G3QEH0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:SFXN4
gene id: 9595:SFXN4
uniprot id: A0A2I2ZE28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9595:LTF
gene id: 9595:LTF
uniprot id: G3QYG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferrin family.
messages: Cytoplasmic granule
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.

9595:MIEF1
gene id: 9595:MIEF1
uniprot id: G3SJU6
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9595:NRG3
gene id: 9595:NRG3
uniprot id: A0A2I2ZMU8
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TNFSF10
gene id: 9595:TNFSF10
uniprot id: G3RF33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9595:EMC1
gene id: 9595:EMC1
uniprot id: G3QE37
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:NASP
gene id: 9595:NASP
uniprot id: A0A2I2Z1E4
uniprot id: G3S5W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9595:SLC17A3
gene id: 9595:SLC17A3
uniprot id: G3SJE4
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101150395
gene id: 9595:LOC101150395
uniprot id: A0A2I2YH71
names: Subcellular Location Annotation
messages: Membrane

9595:FZD5
gene id: 9595:FZD5
uniprot id: A0A2I2YRF3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LOC101149653
gene id: 9595:LOC101149653
uniprot id: G3RA96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101133112
gene id: 9595:LOC101133112
uniprot id: G3REG1
names: Subcellular Location Annotation
messages: Membrane

9595:SH3GL2
gene id: 9595:SH3GL2
uniprot id: A0A2I2Y4S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9595:ITGAD
gene id: 9595:ITGAD
uniprot id: G3QTG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:CBX8
gene id: 9595:CBX8
uniprot id: G3QPR3
names: Subcellular Location Annotation
messages: Nucleus

9595:TMEM198
gene id: 9595:TMEM198
uniprot id: G3QM05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9595:RPL12
gene id: 9595:RPL12
uniprot id: G3QEE4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9595:STAM2
gene id: 9595:STAM2
uniprot id: G3R732
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9595:CBFA2T2
gene id: 9595:CBFA2T2
uniprot id: A0A2I2Z9T5
uniprot id: A0A2I2ZC47
names: Similarity
messages: Belongs to the CBFA2T family.

9595:HSP90AB1
gene id: 9595:HSP90AB1
uniprot id: G3R0K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9595:SNTA1
gene id: 9595:SNTA1
uniprot id: G3QZK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9595:SCN1B
gene id: 9595:SCN1B
uniprot id: G3QQT7
names: Subcellular Location Annotation
messages: Membrane

9595:URGCP
gene id: 9595:URGCP
uniprot id: A0A2I2Y1N5
uniprot id: A0A2I2Z8Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9595:ZNF280A
gene id: 9595:ZNF280A
uniprot id: G3S5R8
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9595:TXNRD1
gene id: 9595:TXNRD1
uniprot id: G3RS10
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

9595:KRT78
gene id: 9595:KRT78
uniprot id: G3QMQ7
names: Similarity
messages: Belongs to the intermediate filament family.

9595:KCNH8
gene id: 9595:KCNH8
uniprot id: G3RMV3
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9595:PFN1
gene id: 9595:PFN1
uniprot id: G3S0W1
names: Similarity
messages: Belongs to the profilin family.

9595:ANKRD13A
gene id: 9595:ANKRD13A
uniprot id: G3R232
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9595:TMEM106C
gene id: 9595:TMEM106C
uniprot id: G3QNU6
names: Similarity
messages: Belongs to the TMEM106 family.

9595:TPM1
gene id: 9595:TPM1
uniprot id: A0A2I2ZAB7
uniprot id: A0A2I2ZKG9
uniprot id: G3R169
uniprot id: G3RWR8
uniprot id: G3S1U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9595:CFLAR
gene id: 9595:CFLAR
uniprot id: G3R5V9
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:DUS4L
gene id: 9595:DUS4L
uniprot id: G3QML1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9595:LAPTM5
gene id: 9595:LAPTM5
uniprot id: G3RLG7
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9595:LOC101141497
gene id: 9595:LOC101141497
uniprot id: G3R9Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9595:DHX29
gene id: 9595:DHX29
uniprot id: G3QHK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

9595:NUP155
gene id: 9595:NUP155
uniprot id: G3RZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.
messages: nuclear pore complex

9595:FFAR2
gene id: 9595:FFAR2
uniprot id: G3QSU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101130814
gene id: 9595:LOC101130814
uniprot id: G3RRH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:RIPPLY1
gene id: 9595:RIPPLY1
uniprot id: G3QRS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9595:FNBP1
gene id: 9595:FNBP1
uniprot id: A0A2I2Z1L0
uniprot id: A0A2I2Z1V6
uniprot id: A0A2I2Z406
names: Subcellular Location Annotation
messages: cytoskeleton

9595:LIN7C
gene id: 9595:LIN7C
uniprot id: G3RYG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9595:ID3
gene id: 9595:ID3
uniprot id: G3QZD1
names: Subcellular Location Annotation
messages: Nucleus

9595:DPH1
gene id: 9595:DPH1
uniprot id: A0A2I2Z179
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

9595:SS18L2
gene id: 9595:SS18L2
uniprot id: A0A2I2ZM28
names: Similarity
messages: Belongs to the SS18 family.

9595:LOC109027306
gene id: 9595:LOC109027306
uniprot id: A0A2I2ZZ53
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:NDUFB10
gene id: 9595:NDUFB10
uniprot id: Q0MQF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Complex I is composed of 45 different subunits. Interacts with CHCHD4.
messages: Mitochondrion inner membrane

9595:ARL2BP
gene id: 9595:ARL2BP
uniprot id: G3QRU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9595:SYNJ2
gene id: 9595:SYNJ2
uniprot id: G3R949
uniprot id: G3RRS3
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9595:CLDN12
gene id: 9595:CLDN12
uniprot id: A0A2I2Y704
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9595:LOC101139737
gene id: 9595:LOC101139737
uniprot id: G3R411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:NXPH2
gene id: 9595:NXPH2
uniprot id: G3RWC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9595:CHST13
gene id: 9595:CHST13
uniprot id: G3RDQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:DDX1
gene id: 9595:DDX1
uniprot id: G3R9U8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule
messages: RNA helicase.
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.

9595:TAS2R8
gene id: 9595:TAS2R8
uniprot id: Q646A3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9595:NTMT1
gene id: 9595:NTMT1
uniprot id: G3QJN0
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9595:NPSR1
gene id: 9595:NPSR1
uniprot id: A0A2I2ZKT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:NANOS2
gene id: 9595:NANOS2
uniprot id: G3RC89
names: Similarity
messages: Belongs to the nanos family.

9595:PIANP
gene id: 9595:PIANP
uniprot id: G3SIQ5
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101153414
gene id: 9595:LOC101153414
uniprot id: G3RXT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:NME6
gene id: 9595:NME6
uniprot id: A0A2I2YRA6
names: Similarity
messages: Belongs to the NDK family.

9595:DMAP1
gene id: 9595:DMAP1
uniprot id: G3QLW4
names: Subcellular Location Annotation
messages: Nucleus

9595:FAM83F
gene id: 9595:FAM83F
uniprot id: G3QVF6
names: Similarity
messages: Belongs to the FAM83 family.

9595:TIPIN
gene id: 9595:TIPIN
uniprot id: G3QCW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9595:EIF4E3
gene id: 9595:EIF4E3
uniprot id: A0A2I2Z4K7
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9595:AQP1
gene id: 9595:AQP1
uniprot id: G3R332
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9595:EIF4A2
gene id: 9595:EIF4A2
uniprot id: G3QSU6
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9595:BRINP1
gene id: 9595:BRINP1
uniprot id: G3QR50
names: Similarity
messages: Belongs to the BRINP family.

9595:ELAVL2
gene id: 9595:ELAVL2
uniprot id: A0A2I2ZC03
uniprot id: G3SGG8
names: Similarity
messages: Belongs to the RRM elav family.

9595:TRPM3
gene id: 9595:TRPM3
uniprot id: A0A2I2Y5U9
names: Subcellular Location Annotation
messages: Membrane

9595:FUCA2
gene id: 9595:FUCA2
uniprot id: G3R6L9
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9595:KAT2B
gene id: 9595:KAT2B
uniprot id: G3RKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9595:ZNF703
gene id: 9595:ZNF703
uniprot id: G3R800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

9595:VDR
gene id: 9595:VDR
uniprot id: G3RK17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Nucleus

9595:SEMA3F
gene id: 9595:SEMA3F
uniprot id: A0A2I2YT32
uniprot id: A0A2I2YUI3
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:C11H11orf54
gene id: 9595:C11H11orf54
uniprot id: A0A2I2Y5F9
uniprot id: G3RFI0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9595:AGL
gene id: 9595:AGL
uniprot id: A0A2I2YDM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

9595:CIAO1
gene id: 9595:CIAO1
uniprot id: A0A2I2ZVX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9595:LOC101131885
gene id: 9595:LOC101131885
uniprot id: G3S4Z9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:HEBP2
gene id: 9595:HEBP2
uniprot id: G3QGU6
names: Similarity
messages: Belongs to the HEBP family.

9595:ARG1
gene id: 9595:ARG1
uniprot id: G3RRL0
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9595:SPRR2G
gene id: 9595:SPRR2G
uniprot id: A0A2I2Z4I8
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:TOR1AIP1
gene id: 9595:TOR1AIP1
uniprot id: A0A2I2ZRA2
uniprot id: G3RDA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9595:PFAS
gene id: 9595:PFAS
uniprot id: G3QZU5
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

9595:LOC101142132
gene id: 9595:LOC101142132
uniprot id: A0A2I2Y3S5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:ESF1
gene id: 9595:ESF1
uniprot id: G3QUZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9595:LOC101148684
gene id: 9595:LOC101148684
uniprot id: G3SKC3
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9595:STN1
gene id: 9595:STN1
uniprot id: A0A2I2YS00
uniprot id: A0A2I2YUX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9595:BNIP1
gene id: 9595:BNIP1
uniprot id: G3QIJ2
uniprot id: G3SHW1
names: Subcellular Location Annotation
messages: Membrane

9595:CSF3R
gene id: 9595:CSF3R
uniprot id: G3S1M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9595:WNT8B
gene id: 9595:WNT8B
uniprot id: G3RFB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:GINS1
gene id: 9595:GINS1
uniprot id: G3QJ52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9595:NTSR1
gene id: 9595:NTSR1
uniprot id: G3RLF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:EPOR
gene id: 9595:EPOR
uniprot id: G3RT53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Forms homodimers on EPO stimulation.
messages: Membrane
messages: Receptor for erythropoietin.

9595:LOC109023678
gene id: 9595:LOC109023678
uniprot id: G3RQM3
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9595:DSCC1
gene id: 9595:DSCC1
uniprot id: A0A2I2ZVY3
names: Similarity
messages: Belongs to the DCC1 family.

9595:SNX10
gene id: 9595:SNX10
uniprot id: G3S6L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9595:CCNB1
gene id: 9595:CCNB1
uniprot id: G3QGP3
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

9595:ADGRD1
gene id: 9595:ADGRD1
uniprot id: A0A2I2YC34
uniprot id: A0A2I2YZY1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:IGBP1
gene id: 9595:IGBP1
uniprot id: G3RW45
names: Similarity
messages: Belongs to the IGBP1/TAP42 family.

9595:SUSD5
gene id: 9595:SUSD5
uniprot id: A0A2I2YKD5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ZNF16
gene id: 9595:ZNF16
uniprot id: A1YF12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Also plays a role as an inhibitor of cell apoptosis (By similarity).
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Interacts with INCA1; the interaction inhibits INCA1 activity and induces the cell cycle process.
messages: Nucleus

9595:SAXO1
gene id: 9595:SAXO1
uniprot id: G3RYC0
names: Similarity
messages: Belongs to the FAM154 family.

9595:TRABD2A
gene id: 9595:TRABD2A
uniprot id: A0A2I2YXX1
uniprot id: A0A2I2Z6M7
uniprot id: G3QN64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9595:RPL18A
gene id: 9595:RPL18A
uniprot id: G3QK54
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9595:RNASE3
gene id: 9595:RNASE3
uniprot id: P47778
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pancreatic ribonuclease family.
messages: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity (By similarity).
messages: Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with phospholipid bilayers.
messages: Secreted

9595:TAF1A
gene id: 9595:TAF1A
uniprot id: G3QFT8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9595:MFSD4B
gene id: 9595:MFSD4B
uniprot id: G3R0E5
names: Subcellular Location Annotation
messages: Membrane

9595:IL20
gene id: 9595:IL20
uniprot id: G3RBT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9595:ADAM29
gene id: 9595:ADAM29
uniprot id: G3R6U2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SSR4
gene id: 9595:SSR4
uniprot id: A0A2I2ZTV2
uniprot id: G3RXH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9595:ZIC4
gene id: 9595:ZIC4
uniprot id: G3R0N1
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9595:ANXA11
gene id: 9595:ANXA11
uniprot id: G3QST6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9595:SLC25A47
gene id: 9595:SLC25A47
uniprot id: G3R3T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:PAEP
gene id: 9595:PAEP
uniprot id: G3QTP4
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9595:FBP2
gene id: 9595:FBP2
uniprot id: G3QSB7
names: Similarity
messages: Belongs to the FBPase class 1 family.

9595:HSCB
gene id: 9595:HSCB
uniprot id: G3RLQ2
names: Similarity
messages: Belongs to the HscB family.

9595:DIPK1B
gene id: 9595:DIPK1B
uniprot id: G3RJ05
names: Similarity
messages: Belongs to the DIPK family.

9595:MLNR
gene id: 9595:MLNR
uniprot id: G3QMK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:CLTRN
gene id: 9595:CLTRN
uniprot id: G3SF03
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:GOLGA5
gene id: 9595:GOLGA5
uniprot id: G3SJM4
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

9595:MANBAL
gene id: 9595:MANBAL
uniprot id: G3S5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9595:MED22
gene id: 9595:MED22
uniprot id: G3RET4
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9595:MMP27
gene id: 9595:MMP27
uniprot id: G3R045
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:PARP1
gene id: 9595:PARP1
uniprot id: G3SBV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

9595:TBRG1
gene id: 9595:TBRG1
uniprot id: G3QME3
names: Subcellular Location Annotation
messages: Nucleus

9595:DBNDD1
gene id: 9595:DBNDD1
uniprot id: A0A2I2Y6M9
names: Similarity
messages: Belongs to the dysbindin family.

9595:ATP6V0A4
gene id: 9595:ATP6V0A4
uniprot id: G3R0B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9595:SCML2
gene id: 9595:SCML2
uniprot id: G3RIQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9595:RNASEK
gene id: 9595:RNASEK
uniprot id: G3R2T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Membrane

9595:DRP2
gene id: 9595:DRP2
uniprot id: G3QNS2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.
messages: dendrite

9595:GUCA2A
gene id: 9595:GUCA2A
uniprot id: G3R796
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9595:LOC101136823
gene id: 9595:LOC101136823
uniprot id: G3RP05
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9595:JPT1
gene id: 9595:JPT1
uniprot id: G3RDN8
uniprot id: G3RDP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9595:CCL22
gene id: 9595:CCL22
uniprot id: A0A2I2ZUR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:IL12A
gene id: 9595:IL12A
uniprot id: G3QVB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

9595:LOC101148492
gene id: 9595:LOC101148492
uniprot id: G3SBD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LZTS2
gene id: 9595:LZTS2
uniprot id: G3RHD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

9595:NDRG2
gene id: 9595:NDRG2
uniprot id: A0A2I2ZPJ6
uniprot id: G3QR61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

9595:TSEN34
gene id: 9595:TSEN34
uniprot id: G3QYS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9595:ASCC3
gene id: 9595:ASCC3
uniprot id: G3QJZ8
names: Similarity
messages: Belongs to the helicase family.

9595:DSTN
gene id: 9595:DSTN
uniprot id: G3R0W0
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9595:CCDC47
gene id: 9595:CCDC47
uniprot id: G3RR28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC47 family.
messages: Rough endoplasmic reticulum membrane

9595:IL17RB
gene id: 9595:IL17RB
uniprot id: G3QHE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:EDN2
gene id: 9595:EDN2
uniprot id: G3RLB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9595:CRYBB3
gene id: 9595:CRYBB3
uniprot id: G3SCP7
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9595:LOC101135831
gene id: 9595:LOC101135831
uniprot id: G3RRU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ITM2B
gene id: 9595:ITM2B
uniprot id: G3QV34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9595:PITPNM1
gene id: 9595:PITPNM1
uniprot id: G3R3S8
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9595:MAT2B
gene id: 9595:MAT2B
uniprot id: A0A2I2ZDS3
uniprot id: G3S8V1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9595:FAM3A
gene id: 9595:FAM3A
uniprot id: A0A2I2Y1L4
uniprot id: A0A2I2ZLG6
uniprot id: G3QRC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9595:PFKL
gene id: 9595:PFKL
uniprot id: G3RVJ3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SLC44A3
gene id: 9595:SLC44A3
uniprot id: G3RDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9595:CD34
gene id: 9595:CD34
uniprot id: G3S916
uniprot id: G3SID7
names: Subcellular Location Annotation
messages: Membrane

9595:HDHD3
gene id: 9595:HDHD3
uniprot id: G3QVP3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9595:TAP2
gene id: 9595:TAP2
uniprot id: G3RWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

9595:FUZ
gene id: 9595:FUZ
uniprot id: G3R3T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

9595:SUCLG2
gene id: 9595:SUCLG2
uniprot id: A0A2I2Y602
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9595:GOLT1A
gene id: 9595:GOLT1A
uniprot id: G3R6G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9595:UBE2A
gene id: 9595:UBE2A
uniprot id: G3RGA3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:ARRB2
gene id: 9595:ARRB2
uniprot id: G3QRU2
names: Similarity
messages: Belongs to the arrestin family.

9595:ITGA2B
gene id: 9595:ITGA2B
uniprot id: G3RAS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:CRCP
gene id: 9595:CRCP
uniprot id: A0A2I2YVB3
uniprot id: A0A2I2ZC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9595:G6PC3
gene id: 9595:G6PC3
uniprot id: G3R4W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9595:MTMR12
gene id: 9595:MTMR12
uniprot id: A0A2I2YTX3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9595:FBN1
gene id: 9595:FBN1
uniprot id: G3QLA9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:HOXB5
gene id: 9595:HOXB5
uniprot id: G3S8F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9595:AJAP1
gene id: 9595:AJAP1
uniprot id: A0A2I2ZN79
names: Subcellular Location Annotation
messages: Membrane

9595:SLC7A7
gene id: 9595:SLC7A7
uniprot id: G3QM98
names: Subcellular Location Annotation
messages: Membrane

9595:SKA3
gene id: 9595:SKA3
uniprot id: G3REY3
uniprot id: G3S4M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9595:LOC101127474
gene id: 9595:LOC101127474
uniprot id: A0A2I2ZVX9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

9595:PLA2G4E
gene id: 9595:PLA2G4E
uniprot id: G3R844
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9595:MCMBP
gene id: 9595:MCMBP
uniprot id: G3QT73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

9595:SLC35C1
gene id: 9595:SLC35C1
uniprot id: G3QG59
names: Subcellular Location Annotation
messages: Membrane

9595:IL1RAPL2
gene id: 9595:IL1RAPL2
uniprot id: G3QJX3
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9595:CRYBA2
gene id: 9595:CRYBA2
uniprot id: G3R5E7
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9595:DRD2
gene id: 9595:DRD2
uniprot id: G3S8W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9595:TDP1
gene id: 9595:TDP1
uniprot id: A0A2I2YJL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9595:SGO2
gene id: 9595:SGO2
uniprot id: A0A2I2YSY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9595:LAMC2
gene id: 9595:LAMC2
uniprot id: G3RF36
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9595:LDHC
gene id: 9595:LDHC
uniprot id: A0A2I2YN53
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9595:NDRG4
gene id: 9595:NDRG4
uniprot id: A0A2I2Y8X7
uniprot id: A0A2I2ZFZ6
uniprot id: G3R275
names: Similarity
messages: Belongs to the NDRG family.

9595:AGTRAP
gene id: 9595:AGTRAP
uniprot id: G3S5X3
names: Subcellular Location Annotation
messages: Membrane

9595:PPM1B
gene id: 9595:PPM1B
uniprot id: A0A2I2Z9I2
uniprot id: G3REP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9595:LOC101132862
gene id: 9595:LOC101132862
uniprot id: G3QV25
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:GTF2F1
gene id: 9595:GTF2F1
uniprot id: A0A2I2ZFR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

9595:INKA1
gene id: 9595:INKA1
uniprot id: G3R925
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9595:KCNH6
gene id: 9595:KCNH6
uniprot id: A0A2I2Y2F9
uniprot id: G3RL09
names: Subcellular Location Annotation
messages: Membrane

9595:C6H6orf58
gene id: 9595:C6H6orf58
uniprot id: G3QPL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

9595:JUND
gene id: 9595:JUND
uniprot id: G3S843
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9595:SDC4
gene id: 9595:SDC4
uniprot id: G3QNG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9595:ANXA4
gene id: 9595:ANXA4
uniprot id: G3QI88
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

9595:OPA1
gene id: 9595:OPA1
uniprot id: A0A2I2Y2W8
uniprot id: A0A2I2Y7Q2
uniprot id: G3S1U3
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9595:RPL21
gene id: 9595:RPL21
uniprot id: G3QKH6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9595:CSN1S1
gene id: 9595:CSN1S1
uniprot id: A0A2I2Y2L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Secreted

9595:CD44
gene id: 9595:CD44
uniprot id: A0A2I2YTE1
uniprot id: A0A2I2Z590
uniprot id: A0A2I2ZPR8
uniprot id: G3QEY3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

9595:ATXN2
gene id: 9595:ATXN2
uniprot id: A0A2I2Z076
names: Similarity
messages: Belongs to the ataxin-2 family.

9595:CAST
gene id: 9595:CAST
uniprot id: A0A2I2YI04
uniprot id: A0A2I2YK81
uniprot id: A0A2I2YMS0
uniprot id: A0A2I2YUD0
uniprot id: A0A2I2Z302
uniprot id: G3R1K6
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9595:SPEM2
gene id: 9595:SPEM2
uniprot id: G3R821
names: Subcellular Location Annotation
messages: Membrane

9595:PPP1R2
gene id: 9595:PPP1R2
uniprot id: G3RQX8
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9595:CDK2
gene id: 9595:CDK2
uniprot id: G3QIR0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:TIGD4
gene id: 9595:TIGD4
uniprot id: G3R842
names: Subcellular Location Annotation
messages: Nucleus

9595:CFAP45
gene id: 9595:CFAP45
uniprot id: A0A2I2Y700
names: Similarity
messages: Belongs to the CFAP45 family.

9595:ITGA8
gene id: 9595:ITGA8
uniprot id: A0A2I2YGH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:GLRA4
gene id: 9595:GLRA4
uniprot id: G3RDJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9595:SLC25A3
gene id: 9595:SLC25A3
uniprot id: G3RII8
uniprot id: G3SET8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9595:CPA2
gene id: 9595:CPA2
uniprot id: G3QIZ6
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:NR2C1
gene id: 9595:NR2C1
uniprot id: A0A2I2ZHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:TDO2
gene id: 9595:TDO2
uniprot id: G3RW40
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TMEM65
gene id: 9595:TMEM65
uniprot id: A0A2I2ZLW7
names: Subcellular Location Annotation
messages: Membrane

9595:MZT1
gene id: 9595:MZT1
uniprot id: A0A2I2YEM2
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9595:YWHAZ
gene id: 9595:YWHAZ
uniprot id: G3RS45
names: Similarity
messages: Belongs to the 14-3-3 family.

9595:GNS
gene id: 9595:GNS
uniprot id: G3RH59
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9595:GASK1B
gene id: 9595:GASK1B
uniprot id: A0A2I2YC52
names: Similarity
messages: Belongs to the GASK family.

9595:CDK2AP1
gene id: 9595:CDK2AP1
uniprot id: A0A2I2Z8T4
uniprot id: G3R2A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9595:EXOC8
gene id: 9595:EXOC8
uniprot id: G3S1F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9595:GHRHR
gene id: 9595:GHRHR
uniprot id: G3QG25
names: Subcellular Location Annotation
messages: Membrane

9595:BTG4
gene id: 9595:BTG4
uniprot id: A0A2I2YKN2
names: Similarity
messages: Belongs to the BTG family.

9595:SCFD2
gene id: 9595:SCFD2
uniprot id: G3R939
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9595:VSIG1
gene id: 9595:VSIG1
uniprot id: G3R4U8
uniprot id: G3RZ93
names: Subcellular Location Annotation
messages: Membrane

9595:CDC37
gene id: 9595:CDC37
uniprot id: G3S245
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9595:HNRNPK
gene id: 9595:HNRNPK
uniprot id: A0A2I2Z071
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9595:CD82
gene id: 9595:CD82
uniprot id: A0A2I2Z3R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:EYA4
gene id: 9595:EYA4
uniprot id: A0A2I2Z304
uniprot id: A0A2I2ZPX3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9595:AFF3
gene id: 9595:AFF3
uniprot id: G3SKU4
names: Similarity
messages: Belongs to the AF4 family.

9595:ART1
gene id: 9595:ART1
uniprot id: G3R210
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9595:CHRDL2
gene id: 9595:CHRDL2
uniprot id: G3SB86
names: Subcellular Location Annotation
messages: Secreted

9595:CA8
gene id: 9595:CA8
uniprot id: G3RXT0
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9595:PLXNB2
gene id: 9595:PLXNB2
uniprot id: G3QUT5
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:FBP1
gene id: 9595:FBP1
uniprot id: G3QSC2
names: Similarity
messages: Belongs to the FBPase class 1 family.

9595:CTTNBP2
gene id: 9595:CTTNBP2
uniprot id: G3RG49
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.
messages: Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
messages: cell cortex
messages: dendritic spine

9595:NDUFA6
gene id: 9595:NDUFA6
uniprot id: Q0MQA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:GPR83
gene id: 9595:GPR83
uniprot id: G3QXI1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:CPA1
gene id: 9595:CPA1
uniprot id: G3QJ04
names: Similarity
messages: Belongs to the peptidase M14 family.

9595:DHPS
gene id: 9595:DHPS
uniprot id: G3RC40
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

9595:CD99
gene id: 9595:CD99
uniprot id: G3R4R1
names: Similarity
messages: Belongs to the CD99 family.

9595:ARL3
gene id: 9595:ARL3
uniprot id: G3SH85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9595:BCL7C
gene id: 9595:BCL7C
uniprot id: G3QSJ5
names: Similarity
messages: Belongs to the BCL7 family.

9595:GSN
gene id: 9595:GSN
uniprot id: A0A2I2ZLD6
uniprot id: A0A2I2ZVU1
uniprot id: G3R3X5
uniprot id: G3S1L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the villin/gelsolin family.
messages: Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR.
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
messages: cytoskeleton

9595:PHAF1
gene id: 9595:PHAF1
uniprot id: G3R884
names: Similarity
messages: Belongs to the PHAF1 family.

9595:MYH2
gene id: 9595:MYH2
uniprot id: G3RN81
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:TMEM186
gene id: 9595:TMEM186
uniprot id: G3R3P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9595:SLC24A4
gene id: 9595:SLC24A4
uniprot id: G3QYN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9595:LOC101139746
gene id: 9595:LOC101139746
uniprot id: G3REL1
names: Similarity
messages: Belongs to the peptidase S8 family.

9595:RNF4
gene id: 9595:RNF4
uniprot id: A0A2I2ZC58
names: Subcellular Location Annotation
messages: Nucleus

9595:YTHDC1
gene id: 9595:YTHDC1
uniprot id: A0A2I2ZW06
uniprot id: G3S4Z8
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9595:PLPP1
gene id: 9595:PLPP1
uniprot id: G3QHL3
uniprot id: G3RWA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9595:PIK3R1
gene id: 9595:PIK3R1
uniprot id: A0A2I2YFF4
uniprot id: A0A2I2ZF31
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9595:GLYAT
gene id: 9595:GLYAT
uniprot id: G3QNC8
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9595:SSR3
gene id: 9595:SSR3
uniprot id: G3SJT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9595:EVA1B
gene id: 9595:EVA1B
uniprot id: G3QVK8
names: Similarity
messages: Belongs to the EVA1 family.

9595:MYADML2
gene id: 9595:MYADML2
uniprot id: A0A2I2ZF93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9595:CRISP2
gene id: 9595:CRISP2
uniprot id: G3S7B6
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:EIF1B
gene id: 9595:EIF1B
uniprot id: G3QZ21
names: Similarity
messages: Belongs to the SUI1 family.

9595:PLA1A
gene id: 9595:PLA1A
uniprot id: G3QKJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9595:LOC101134111
gene id: 9595:LOC101134111
uniprot id: G3R9R6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:HINT2
gene id: 9595:HINT2
uniprot id: G3R6M3
names: Similarity
messages: Belongs to the HINT family.

9595:AK1
gene id: 9595:AK1
uniprot id: A0A2I2YKU8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9595:NDUFAF3
gene id: 9595:NDUFAF3
uniprot id: G3RBQ0
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9595:CEBPZ
gene id: 9595:CEBPZ
uniprot id: A0A2I2YFX5
uniprot id: G3R6U5
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9595:SNU13
gene id: 9595:SNU13
uniprot id: A0A2I2YHN2
uniprot id: G3S6T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9595:STX6
gene id: 9595:STX6
uniprot id: G3QEM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9595:ELMO1
gene id: 9595:ELMO1
uniprot id: G3RL99
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9595:NUP85
gene id: 9595:NUP85
uniprot id: G3QUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9595:MRAP
gene id: 9595:MRAP
uniprot id: G3QDG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:FAM24A
gene id: 9595:FAM24A
uniprot id: G3QW89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM24 family.
messages: Secreted

9595:NRXN3
gene id: 9595:NRXN3
uniprot id: A0A2I2ZRG5
uniprot id: A0A2I2ZVI8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Presynaptic cell membrane

9595:PXMP4
gene id: 9595:PXMP4
uniprot id: A0A2I2Y5V8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9595:PRL
gene id: 9595:PRL
uniprot id: G3QG92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9595:ARV1
gene id: 9595:ARV1
uniprot id: G3S847
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9595:PABPC3
gene id: 9595:PABPC3
uniprot id: A0A2I2ZA10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9595:GLRB
gene id: 9595:GLRB
uniprot id: G3S3Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9595:ETFDH
gene id: 9595:ETFDH
uniprot id: G3S2H8
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9595:SNAP47
gene id: 9595:SNAP47
uniprot id: A0A2I2Z1Y1
uniprot id: G3QZE5
names: Similarity
messages: Belongs to the SVAP1 family.

9595:ASAH1
gene id: 9595:ASAH1
uniprot id: G3RZ91
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9595:CTNNA3
gene id: 9595:CTNNA3
uniprot id: A0A2I2ZCF0
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9595:LOC101145021
gene id: 9595:LOC101145021
uniprot id: A0A2I2Z715
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:AKAP5
gene id: 9595:AKAP5
uniprot id: G3SEG4
names: Subcellular Location Annotation
messages: Membrane

9595:CEBPD
gene id: 9595:CEBPD
uniprot id: G3QYG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9595:UTP11
gene id: 9595:UTP11
uniprot id: A0A2I2YQU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9595:RNF39
gene id: 9595:RNF39
uniprot id: G3RPQ0
names: Subcellular Location Annotation
messages: Cytoplasm

9595:PRPH2
gene id: 9595:PRPH2
uniprot id: G3QNA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9595:PTMA
gene id: 9595:PTMA
uniprot id: A0A2I2ZUW0
names: Similarity
messages: Belongs to the pro/parathymosin family.

9595:NR2E1
gene id: 9595:NR2E1
uniprot id: G3RWA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:FPR1
gene id: 9595:FPR1
uniprot id: G3QRA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9595:PSD
gene id: 9595:PSD
uniprot id: G3QVQ5
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9595:MYCBP
gene id: 9595:MYCBP
uniprot id: G3QSP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

9595:TPST1
gene id: 9595:TPST1
uniprot id: G3RXV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9595:GPRC5A
gene id: 9595:GPRC5A
uniprot id: G3RIM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:TEK
gene id: 9595:TEK
uniprot id: G3RIN5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:GALK2
gene id: 9595:GALK2
uniprot id: A0A2I2YIZ2
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9595:CAMK2N1
gene id: 9595:CAMK2N1
uniprot id: G3QUX8
names: Similarity
messages: Belongs to the CAMK2N family.

9595:LOC101147253
gene id: 9595:LOC101147253
uniprot id: G3SIR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:LTV1
gene id: 9595:LTV1
uniprot id: G3SJE5
names: Similarity
messages: Belongs to the LTV1 family.

9595:FOXN2
gene id: 9595:FOXN2
uniprot id: A0A2I2YXV7
names: Subcellular Location Annotation
messages: Nucleus

9595:MFAP2
gene id: 9595:MFAP2
uniprot id: G3RJF4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:LOC101125335
gene id: 9595:LOC101125335
uniprot id: G3QP21
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9595:PHF5A
gene id: 9595:PHF5A
uniprot id: G3QFL1
names: Similarity
messages: Belongs to the PHF5 family.

9595:HUS1B
gene id: 9595:HUS1B
uniprot id: G3QWT6
names: Similarity
messages: Belongs to the HUS1 family.

9595:PDCL
gene id: 9595:PDCL
uniprot id: G3RC41
names: Similarity
messages: Belongs to the phosducin family.

9595:ESRRA
gene id: 9595:ESRRA
uniprot id: G3QG65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9595:GPR101
gene id: 9595:GPR101
uniprot id: G3QRA2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:FAM3B
gene id: 9595:FAM3B
uniprot id: A0A2I2ZCK4
uniprot id: G3SA99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9595:NIFK
gene id: 9595:NIFK
uniprot id: G3RQP7
names: Subcellular Location Annotation
messages: nucleolus

9595:CHRNA1
gene id: 9595:CHRNA1
uniprot id: A0A2I2ZA95
uniprot id: G3S4U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:STC1
gene id: 9595:STC1
uniprot id: G3SGP0
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9595:TP53INP2
gene id: 9595:TP53INP2
uniprot id: G3S6E0
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9595:LOC101151965
gene id: 9595:LOC101151965
uniprot id: G3QCV6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:ATP1A4
gene id: 9595:ATP1A4
uniprot id: G3RB63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9595:MPHOSPH10
gene id: 9595:MPHOSPH10
uniprot id: G3QMT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9595:GIMAP6
gene id: 9595:GIMAP6
uniprot id: G3QEB2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9595:PDGFD
gene id: 9595:PDGFD
uniprot id: G3QI67
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:HSPA1L
gene id: 9595:HSPA1L
uniprot id: G3S9G1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9595:APOA4
gene id: 9595:APOA4
uniprot id: G3S2R4
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9595:MAPK4
gene id: 9595:MAPK4
uniprot id: G3RXT3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9595:TNR
gene id: 9595:TNR
uniprot id: G3RJQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9595:DYDC2
gene id: 9595:DYDC2
uniprot id: A0A2I2ZUC6
uniprot id: G3QMF0
names: Similarity
messages: Belongs to the dpy-30 family.

9595:LOC101129166
gene id: 9595:LOC101129166
uniprot id: G3RKB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:TMEM38B
gene id: 9595:TMEM38B
uniprot id: A0A2I2YFB8
uniprot id: G3QWA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9595:DPY19L3
gene id: 9595:DPY19L3
uniprot id: G3R1A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9595:CPNE8
gene id: 9595:CPNE8
uniprot id: A0A2I2Y4M4
names: Similarity
messages: Belongs to the copine family.

9595:IL25
gene id: 9595:IL25
uniprot id: A0A2I2YV12
names: Similarity
messages: Belongs to the IL-17 family.

9595:CCN3
gene id: 9595:CCN3
uniprot id: G3QJX6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:LOC101154090
gene id: 9595:LOC101154090
uniprot id: A0A2I2YYX3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:TMEM115
gene id: 9595:TMEM115
uniprot id: G3QW27
names: Subcellular Location Annotation
messages: Membrane

9595:UFD1
gene id: 9595:UFD1
uniprot id: G3QNC2
names: Similarity
messages: Belongs to the UFD1 family.

9595:HS6ST2
gene id: 9595:HS6ST2
uniprot id: A0A2I2Z9A8
uniprot id: G3RE22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9595:ARF5
gene id: 9595:ARF5
uniprot id: G3RKR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9595:CBX2
gene id: 9595:CBX2
uniprot id: G3R2W1
names: Subcellular Location Annotation
messages: Nucleus

9595:AIMP2
gene id: 9595:AIMP2
uniprot id: A0A2I2YMA9
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9595:TMOD2
gene id: 9595:TMOD2
uniprot id: G3RI10
names: Subcellular Location Annotation
messages: cytoskeleton

9595:PRC1
gene id: 9595:PRC1
uniprot id: G3QZ43
uniprot id: G3S6K8
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

9595:CPNE4
gene id: 9595:CPNE4
uniprot id: G3R6B4
names: Similarity
messages: Belongs to the copine family.

9595:VPS37D
gene id: 9595:VPS37D
uniprot id: G3QGH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:HPSE
gene id: 9595:HPSE
uniprot id: G3RPR9
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9595:NOL11
gene id: 9595:NOL11
uniprot id: G3RPK8
names: Subcellular Location Annotation
messages: nucleolus

9595:ADCY6
gene id: 9595:ADCY6
uniprot id: G3QIR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9595:TGM7
gene id: 9595:TGM7
uniprot id: G3QXA4
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9595:TATDN3
gene id: 9595:TATDN3
uniprot id: A0A2I2ZVJ7
uniprot id: G3S006
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9595:CCBE1
gene id: 9595:CCBE1
uniprot id: G3RJV0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:HEXD
gene id: 9595:HEXD
uniprot id: G3S931
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

9595:TFB2M
gene id: 9595:TFB2M
uniprot id: G3QFK2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CLDN7
gene id: 9595:CLDN7
uniprot id: G3SJL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:ACTR8
gene id: 9595:ACTR8
uniprot id: G3QEH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9595:ISCA2
gene id: 9595:ISCA2
uniprot id: G3SGX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9595:SLC45A1
gene id: 9595:SLC45A1
uniprot id: G3RF31
names: Subcellular Location Annotation
messages: Membrane

9595:YARS1
gene id: 9595:YARS1
uniprot id: G3RDR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

9595:LIFR
gene id: 9595:LIFR
uniprot id: G3RGA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9595:CHPF
gene id: 9595:CHPF
uniprot id: G3QJT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9595:GNRH1
gene id: 9595:GNRH1
uniprot id: G3QPA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

9595:KCNS1
gene id: 9595:KCNS1
uniprot id: A0A2I2YND0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:PRKAA2
gene id: 9595:PRKAA2
uniprot id: G3R126
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm
messages: Nucleus

9595:RNASE1
gene id: 9595:RNASE1
uniprot id: Q8SQ13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pancreatic ribonuclease family.
messages: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity).
messages: Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein (By similarity).
messages: Secreted

9595:CYLD
gene id: 9595:CYLD
uniprot id: G3S7H6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9595:PTPN18
gene id: 9595:PTPN18
uniprot id: G3RK73
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

9595:LOC101141577
gene id: 9595:LOC101141577
uniprot id: G3QMM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:STAC
gene id: 9595:STAC
uniprot id: G3RCH3
names: Subcellular Location Annotation
messages: sarcolemma

9595:ALDOC
gene id: 9595:ALDOC
uniprot id: G3R2M4
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9595:MRPS31
gene id: 9595:MRPS31
uniprot id: G3QUC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9595:NELL1
gene id: 9595:NELL1
uniprot id: A0A2I2ZNJ6
uniprot id: G3SKE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CORO1B
gene id: 9595:CORO1B
uniprot id: G3R3E7
names: Similarity
messages: Belongs to the WD repeat coronin family.

9595:ARPC2
gene id: 9595:ARPC2
uniprot id: A0A2I2ZVL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9595:EDEM3
gene id: 9595:EDEM3
uniprot id: G3QK44
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9595:IPO4
gene id: 9595:IPO4
uniprot id: G3S5I6
names: Subcellular Location Annotation
messages: Cytoplasm

9595:SRFBP1
gene id: 9595:SRFBP1
uniprot id: G3QXL0
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9595:LOC101137794
gene id: 9595:LOC101137794
uniprot id: G3QKJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ESX1
gene id: 9595:ESX1
uniprot id: G3QMI0
names: Subcellular Location Annotation
messages: Nucleus

9595:WNT10A
gene id: 9595:WNT10A
uniprot id: G3QEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:HOXA3
gene id: 9595:HOXA3
uniprot id: G3QIG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9595:ENTPD3
gene id: 9595:ENTPD3
uniprot id: G3QQQ1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9595:ZNF408
gene id: 9595:ZNF408
uniprot id: G3R3S5
names: Subcellular Location Annotation
messages: Nucleus

9595:EPO
gene id: 9595:EPO
uniprot id: G3RS27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Secreted

9595:GORASP1
gene id: 9595:GORASP1
uniprot id: A0A2I2YV97
uniprot id: G3S3A1
names: Similarity
messages: Belongs to the GORASP family.

9595:SPACA3
gene id: 9595:SPACA3
uniprot id: G3QFN2
uniprot id: G3RQ54
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9595:ALPI
gene id: 9595:ALPI
uniprot id: G3RWG5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9595:LOXHD1
gene id: 9595:LOXHD1
uniprot id: G3SGV7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RNF5
gene id: 9595:RNF5
uniprot id: G3RQU7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9595:GLUD1
gene id: 9595:GLUD1
uniprot id: G3RI93
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

9595:UBE2U
gene id: 9595:UBE2U
uniprot id: G3QGK2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:PTPRN
gene id: 9595:PTPRN
uniprot id: A0A2I2ZUY9
uniprot id: G3R874
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9595:DUSP2
gene id: 9595:DUSP2
uniprot id: G3R650
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9595:TAF5L
gene id: 9595:TAF5L
uniprot id: G3RRZ6
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9595:RXRG
gene id: 9595:RXRG
uniprot id: G3S7Z4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9595:ADGRA1
gene id: 9595:ADGRA1
uniprot id: A0A2I2Y4D5
names: Subcellular Location Annotation
messages: Membrane

9595:ENTR1
gene id: 9595:ENTR1
uniprot id: A0A2I2YCA3
uniprot id: A0A2I2ZUW8
uniprot id: G3R5Q0
names: Similarity
messages: Belongs to the ENTR1 family.

9595:MGST2
gene id: 9595:MGST2
uniprot id: G3QQL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LOC101141336
gene id: 9595:LOC101141336
uniprot id: G3RDV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SKAP2
gene id: 9595:SKAP2
uniprot id: A0A2I2Z1F9
uniprot id: G3QIB0
names: Similarity
messages: Belongs to the SKAP family.

9595:VPS28
gene id: 9595:VPS28
uniprot id: G3SD56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
messages: Membrane

9595:ZDHHC16
gene id: 9595:ZDHHC16
uniprot id: A0A2I2YFV3
uniprot id: A0A2I2Z4U9
uniprot id: A0A2I2ZX16
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:CCHCR1
gene id: 9595:CCHCR1
uniprot id: G3R6G3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9595:ARF1
gene id: 9595:ARF1
uniprot id: G3R6M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9595:KCNH7
gene id: 9595:KCNH7
uniprot id: A0A2I2ZMI5
uniprot id: A0A2I2ZQ14
names: Subcellular Location Annotation
messages: Membrane

9595:RAB3A
gene id: 9595:RAB3A
uniprot id: G3RE65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9595:SOAT1
gene id: 9595:SOAT1
uniprot id: G3S252
uniprot id: G3S4J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:ZNF687
gene id: 9595:ZNF687
uniprot id: G3RGM9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9595:HAMP
gene id: 9595:HAMP
uniprot id: G3QEQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9595:BICC1
gene id: 9595:BICC1
uniprot id: G3QRW0
names: Similarity
messages: Belongs to the BicC family.

9595:TIGD7
gene id: 9595:TIGD7
uniprot id: G3R4K8
names: Subcellular Location Annotation
messages: Nucleus

9595:APOL1
gene id: 9595:APOL1
uniprot id: A0A2I2ZQF1
names: Similarity
messages: Belongs to the apolipoprotein L family.

9595:ZFP36L1
gene id: 9595:ZFP36L1
uniprot id: A0A2I2ZGR6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9595:PGF
gene id: 9595:PGF
uniprot id: G3SE83
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9595:CCDC181
gene id: 9595:CCDC181
uniprot id: A0A2I2YQN5
uniprot id: G3SDR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

9595:PLBD1
gene id: 9595:PLBD1
uniprot id: G3R7A2
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9595:OSMR
gene id: 9595:OSMR
uniprot id: G3RF68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9595:TBX5
gene id: 9595:TBX5
uniprot id: G3RD44
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:ABCB1
gene id: 9595:ABCB1
uniprot id: G3S959
names: Subcellular Location Annotation
messages: Membrane

9595:LOC101144032
gene id: 9595:LOC101144032
uniprot id: G3R5A0
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9595:PTPN13
gene id: 9595:PTPN13
uniprot id: G3RM63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9595:FNIP2
gene id: 9595:FNIP2
uniprot id: G3S532
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9595:FAM174B
gene id: 9595:FAM174B
uniprot id: G3QRM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9595:PLK2
gene id: 9595:PLK2
uniprot id: G3RAD3
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9595:LOC101149901
gene id: 9595:LOC101149901
uniprot id: G3R0E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ANAPC10
gene id: 9595:ANAPC10
uniprot id: G3S5D3
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9595:FLVCR2
gene id: 9595:FLVCR2
uniprot id: G3RS74
names: Subcellular Location Annotation
messages: Membrane

9595:TMEM9B
gene id: 9595:TMEM9B
uniprot id: G3QXS7
names: Similarity
messages: Belongs to the TMEM9 family.

9595:ARHGEF6
gene id: 9595:ARHGEF6
uniprot id: G3RDP0
names: Subcellular Location Annotation
messages: lamellipodium

9595:ENTPD2
gene id: 9595:ENTPD2
uniprot id: G3R7S8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9595:CDA
gene id: 9595:CDA
uniprot id: G3QN51
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

9595:SPOCK3
gene id: 9595:SPOCK3
uniprot id: A0A2I2ZGC3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:VPS33B
gene id: 9595:VPS33B
uniprot id: A0A2I2ZMS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9595:LARS2
gene id: 9595:LARS2
uniprot id: G3RI94
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:ALG11
gene id: 9595:ALG11
uniprot id: G3SAS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9595:KPNA1
gene id: 9595:KPNA1
uniprot id: G3RIQ5
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9595:SUMO1
gene id: 9595:SUMO1
uniprot id: G3S6X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9595:PROM1
gene id: 9595:PROM1
uniprot id: A0A2I2YA46
uniprot id: G3S7V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9595:AP1G1
gene id: 9595:AP1G1
uniprot id: G3RVE5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9595:CXXC5
gene id: 9595:CXXC5
uniprot id: G3RE56
names: Subcellular Location Annotation
messages: Cytoplasm

9595:NPY5R
gene id: 9595:NPY5R
uniprot id: G3QP85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

9595:SUCLA2
gene id: 9595:SUCLA2
uniprot id: G3QYU7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9595:SMAD1
gene id: 9595:SMAD1
uniprot id: G3SBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9595:GABRB1
gene id: 9595:GABRB1
uniprot id: G3SKE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:CEBPG
gene id: 9595:CEBPG
uniprot id: A0A2I2ZAY5
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

9595:THBS4
gene id: 9595:THBS4
uniprot id: G3SD95
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SUPV3L1
gene id: 9595:SUPV3L1
uniprot id: G3QRG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9595:NUP93
gene id: 9595:NUP93
uniprot id: G3R3M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9595:POP5
gene id: 9595:POP5
uniprot id: G3RCE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9595:FADS6
gene id: 9595:FADS6
uniprot id: A0A2I2Y9U1
names: Subcellular Location Annotation
messages: Membrane

9595:FGF7
gene id: 9595:FGF7
uniprot id: G3QRL0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:MRPL44
gene id: 9595:MRPL44
uniprot id: G3RE81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

9595:CALHM6
gene id: 9595:CALHM6
uniprot id: G3QGA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9595:IFI44L
gene id: 9595:IFI44L
uniprot id: G3RCT4
names: Similarity
messages: Belongs to the IFI44 family.

9595:LOC101133285
gene id: 9595:LOC101133285
uniprot id: G3RR03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:NUMB
gene id: 9595:NUMB
uniprot id: A0A2I2YDF7
uniprot id: A0A2I2ZY37
uniprot id: G3QIA3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9595:TMEM151A
gene id: 9595:TMEM151A
uniprot id: G3R2T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9595:FAM98C
gene id: 9595:FAM98C
uniprot id: G3SA68
names: Similarity
messages: Belongs to the FAM98 family.

9595:HSD17B10
gene id: 9595:HSD17B10
uniprot id: G3RYQ4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:USP3
gene id: 9595:USP3
uniprot id: G3SG64
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:LOC101135098
gene id: 9595:LOC101135098
uniprot id: A0A2I2YG23
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:MLLT11
gene id: 9595:MLLT11
uniprot id: A0A2I2Y341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9595:MRPL47
gene id: 9595:MRPL47
uniprot id: G3RSK8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9595:EEIG2
gene id: 9595:EEIG2
uniprot id: A0A2I2ZIZ1
names: Similarity
messages: Belongs to the EEIG family.

9595:UBAP2
gene id: 9595:UBAP2
uniprot id: G3RBZ1
names: Subcellular Location Annotation
messages: Cytoplasm

9595:ADIPOR2
gene id: 9595:ADIPOR2
uniprot id: G3RDI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:WDR55
gene id: 9595:WDR55
uniprot id: G3RC37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

9595:SLC45A3
gene id: 9595:SLC45A3
uniprot id: G3QUX3
names: Subcellular Location Annotation
messages: Membrane

9595:GABARAPL2
gene id: 9595:GABARAPL2
uniprot id: G3R9C1
names: Similarity
messages: Belongs to the ATG8 family.

9595:CNIH1
gene id: 9595:CNIH1
uniprot id: G3RBT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9595:BRINP3
gene id: 9595:BRINP3
uniprot id: G3QZJ0
names: Similarity
messages: Belongs to the BRINP family.

9595:LOC101148074
gene id: 9595:LOC101148074
uniprot id: G3QQ88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9595:TM4SF4
gene id: 9595:TM4SF4
uniprot id: G3QHI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9595:CHST12
gene id: 9595:CHST12
uniprot id: G3RIC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:GAA
gene id: 9595:GAA
uniprot id: G3RAW5
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:HNRNPA3
gene id: 9595:HNRNPA3
uniprot id: G3QTH6
names: Subcellular Location Annotation
messages: Nucleus

9595:MANBA
gene id: 9595:MANBA
uniprot id: G3R2R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9595:ACAD10
gene id: 9595:ACAD10
uniprot id: G3SC08
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9595:SLC25A45
gene id: 9595:SLC25A45
uniprot id: A0A2I2YQ03
uniprot id: A0A2I2Z1P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:FERMT1
gene id: 9595:FERMT1
uniprot id: G3RD95
names: Similarity
messages: Belongs to the kindlin family.

9595:ENKD1
gene id: 9595:ENKD1
uniprot id: G3QMS2
names: Subcellular Location Annotation
messages: cilium axoneme

9595:NDUFB3
gene id: 9595:NDUFB3
uniprot id: Q0MQD1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Methylation at His residues by METTL9 enhances complex I-mediated mitochondrial respiration.
messages: Mitochondrion inner membrane

9595:LOC101144277
gene id: 9595:LOC101144277
uniprot id: Q8SQ79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9595:TRAPPC13
gene id: 9595:TRAPPC13
uniprot id: G3RHF6
uniprot id: G3RMQ9
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9595:ERG28
gene id: 9595:ERG28
uniprot id: G3QUF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LOC101152583
gene id: 9595:LOC101152583
uniprot id: A0A2I2YSB4
names: Similarity
messages: Belongs to the intermediate filament family.

9595:TSPAN13
gene id: 9595:TSPAN13
uniprot id: G3R6D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:CPT1B
gene id: 9595:CPT1B
uniprot id: G3QS89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9595:STX7
gene id: 9595:STX7
uniprot id: G3QNE2
names: Similarity
messages: Belongs to the syntaxin family.

9595:MSH5
gene id: 9595:MSH5
uniprot id: A0A2I2YSF4
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9595:TNFSF11
gene id: 9595:TNFSF11
uniprot id: G3R6F7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9595:OVCH2
gene id: 9595:OVCH2
uniprot id: G3S926
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:HOGA1
gene id: 9595:HOGA1
uniprot id: G3RGV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9595:SH3BP5L
gene id: 9595:SH3BP5L
uniprot id: G3R123
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9595:APEX1
gene id: 9595:APEX1
uniprot id: G3QI91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9595:GDA
gene id: 9595:GDA
uniprot id: A0A2I2Y4Z7
uniprot id: G3QZN7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9595:POLR3D
gene id: 9595:POLR3D
uniprot id: G3QWI8
names: Subcellular Location Annotation
messages: Nucleus

9595:BRK1
gene id: 9595:BRK1
uniprot id: G3RZT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: cytoskeleton

9595:RBM10
gene id: 9595:RBM10
uniprot id: G3QXY4
names: Subcellular Location Annotation
messages: Nucleus

9595:ZC3HAV1
gene id: 9595:ZC3HAV1
uniprot id: G3QEF0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9595:A2ML1
gene id: 9595:A2ML1
uniprot id: G3QPP3
uniprot id: G3SA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9595:THYN1
gene id: 9595:THYN1
uniprot id: G3QV97
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9595:B3GALNT2
gene id: 9595:B3GALNT2
uniprot id: G3RCS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:CRYL1
gene id: 9595:CRYL1
uniprot id: G3R639
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9595:SMPD1
gene id: 9595:SMPD1
uniprot id: G3QI84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

9595:KCNE3
gene id: 9595:KCNE3
uniprot id: A0A2I2Y3G9
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9595:TSPAN11
gene id: 9595:TSPAN11
uniprot id: G3QXD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:FAM83D
gene id: 9595:FAM83D
uniprot id: G3RI11
names: Similarity
messages: Belongs to the FAM83 family.

9595:BRS3
gene id: 9595:BRS3
uniprot id: G3QL90
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9595:BTD
gene id: 9595:BTD
uniprot id: G3RR06
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9595:CTH
gene id: 9595:CTH
uniprot id: G3RK81
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9595:SCGB1C1
gene id: 9595:SCGB1C1
uniprot id: A0A2I2Z0Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9595:LOC101153360
gene id: 9595:LOC101153360
uniprot id: G3SD53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MHC class I family.
messages: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
messages: Involved in the presentation of foreign antigens to the immune system.

9595:HSP90B1
gene id: 9595:HSP90B1
uniprot id: G3QHR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9595:SLC29A2
gene id: 9595:SLC29A2
uniprot id: G3QYC7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9595:LOC101126380
gene id: 9595:LOC101126380
uniprot id: G3REL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MPDU1
gene id: 9595:MPDU1
uniprot id: A0A2I2YM40
uniprot id: G3SDB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9595:GTF2A1L
gene id: 9595:GTF2A1L
uniprot id: G3SHY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9595:OCIAD1
gene id: 9595:OCIAD1
uniprot id: G3QUW6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9595:UBN1
gene id: 9595:UBN1
uniprot id: G3R9Y9
names: Similarity
messages: Belongs to the ubinuclein family.

9595:EPC1
gene id: 9595:EPC1
uniprot id: A0A2I2YFP3
uniprot id: G3QYH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9595:EIF1AX
gene id: 9595:EIF1AX
uniprot id: G3S0P1
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

9595:BUD23
gene id: 9595:BUD23
uniprot id: G3QGH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9595:DDIT4
gene id: 9595:DDIT4
uniprot id: G3QJW5
names: Similarity
messages: Belongs to the DDIT4 family.

9595:CDADC1
gene id: 9595:CDADC1
uniprot id: A0A2I2YRN3
uniprot id: G3QR52
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9595:CPE
gene id: 9595:CPE
uniprot id: G3S2F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Interacts with Secretogranin III/SCG3.
messages: Membrane
messages: Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
messages: secretory vesicle membrane

9595:PSMA4
gene id: 9595:PSMA4
uniprot id: G3QD78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9595:PDK3
gene id: 9595:PDK3
uniprot id: G3SE87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9595:KCNJ10
gene id: 9595:KCNJ10
uniprot id: G3S8U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9595:CAPN6
gene id: 9595:CAPN6
uniprot id: G3QXW3
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SLC39A5
gene id: 9595:SLC39A5
uniprot id: G3R109
names: Subcellular Location Annotation
messages: Membrane

9595:HOXB8
gene id: 9595:HOXB8
uniprot id: A0A2I2Z3F0
names: Subcellular Location Annotation
messages: Nucleus

9595:CCND2
gene id: 9595:CCND2
uniprot id: G3R223
names: Similarity
messages: Belongs to the cyclin family.

9595:DPM1
gene id: 9595:DPM1
uniprot id: A0A2I2ZNK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9595:TMPRSS11F
gene id: 9595:TMPRSS11F
uniprot id: G3QFZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9595:PPM1L
gene id: 9595:PPM1L
uniprot id: A0A2I2YNX0
names: Similarity
messages: Belongs to the PP2C family.

9595:UCN3
gene id: 9595:UCN3
uniprot id: G3RKW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9595:METTL16
gene id: 9595:METTL16
uniprot id: G3R2P8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure.

9595:POU4F3
gene id: 9595:POU4F3
uniprot id: G3R9P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9595:ARHGEF11
gene id: 9595:ARHGEF11
uniprot id: G3RG84
uniprot id: G3SDF2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9595:PRDX2
gene id: 9595:PRDX2
uniprot id: G3S156
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9595:CHDH
gene id: 9595:CHDH
uniprot id: G3QGJ5
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

9595:ERBIN
gene id: 9595:ERBIN
uniprot id: A0A2I2YC48
uniprot id: A0A2I2YNW1
uniprot id: G3QWC1
uniprot id: G3S7K4
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9595:OSTC
gene id: 9595:OSTC
uniprot id: G3RSE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9595:PRDX6
gene id: 9595:PRDX6
uniprot id: G3S6S1
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9595:RANGRF
gene id: 9595:RANGRF
uniprot id: G3R667
names: Similarity
messages: Belongs to the MOG1 family.

9595:ZKSCAN5
gene id: 9595:ZKSCAN5
uniprot id: G3R289
names: Subcellular Location Annotation
messages: Nucleus

9595:APLP1
gene id: 9595:APLP1
uniprot id: A0A2I2Z327
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:NPC1L1
gene id: 9595:NPC1L1
uniprot id: G3S1S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9595:PTER
gene id: 9595:PTER
uniprot id: G3RFD4
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SLC26A11
gene id: 9595:SLC26A11
uniprot id: G3QEC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9595:ALDH1B1
gene id: 9595:ALDH1B1
uniprot id: G3RUF8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:LOC101134045
gene id: 9595:LOC101134045
uniprot id: A0A2I2Z814
uniprot id: G3SBA1
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9595:MMP14
gene id: 9595:MMP14
uniprot id: A0A2I2ZNE4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Cytoplasm
messages: Melanosome

9595:IFI44
gene id: 9595:IFI44
uniprot id: G3RCU3
names: Similarity
messages: Belongs to the IFI44 family.

9595:MYB
gene id: 9595:MYB
uniprot id: A0A2I2ZIL5
uniprot id: G3QGB0
names: Subcellular Location Annotation
messages: Nucleus

9595:SCN5A
gene id: 9595:SCN5A
uniprot id: A0A2I2YCL7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9595:STRADA
gene id: 9595:STRADA
uniprot id: A0A2I2YMG0
uniprot id: A0A2I2Z7A7
uniprot id: G3QU25
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9595:MSL3
gene id: 9595:MSL3
uniprot id: G3QUN5
names: Subcellular Location Annotation
messages: Nucleus

9595:MMACHC
gene id: 9595:MMACHC
uniprot id: G3QRN2
names: Similarity
messages: Belongs to the MMACHC family.

9595:HTRA3
gene id: 9595:HTRA3
uniprot id: G3QRI6
uniprot id: G3RXE2
names: Similarity
messages: Belongs to the peptidase S1C family.

9595:TAS2R16
gene id: 9595:TAS2R16
uniprot id: G3R4A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9595:CHMP2A
gene id: 9595:CHMP2A
uniprot id: G3S820
names: Similarity
messages: Belongs to the SNF7 family.

9595:DYNLRB1
gene id: 9595:DYNLRB1
uniprot id: G3SAD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9595:TMEM39A
gene id: 9595:TMEM39A
uniprot id: G3R863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9595:CHST4
gene id: 9595:CHST4
uniprot id: G3RIA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9595:GPR39
gene id: 9595:GPR39
uniprot id: G3RFA5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:PFDN4
gene id: 9595:PFDN4
uniprot id: G3SA67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9595:PDE11A
gene id: 9595:PDE11A
uniprot id: G3SKK4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:TBCC
gene id: 9595:TBCC
uniprot id: G3QSX2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9595:SLITRK3
gene id: 9595:SLITRK3
uniprot id: G3QIK7
names: Similarity
messages: Belongs to the SLITRK family.

9595:ITGB2
gene id: 9595:ITGB2
uniprot id: G3REV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft

9595:B4GAT1
gene id: 9595:B4GAT1
uniprot id: G3R4Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:IARS2
gene id: 9595:IARS2
uniprot id: G3QWM6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:PPM1F
gene id: 9595:PPM1F
uniprot id: G3QEE2
names: Similarity
messages: Belongs to the PP2C family.

9595:APOLD1
gene id: 9595:APOLD1
uniprot id: A0A2I2YUU2
uniprot id: A0A2I2ZTP6
names: Similarity
messages: Belongs to the apolipoprotein L family.

9595:ZKSCAN4
gene id: 9595:ZKSCAN4
uniprot id: G3RTP5
names: Subcellular Location Annotation
messages: Nucleus

9595:DEFB121
gene id: 9595:DEFB121
uniprot id: G3QKC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:LAPTM4A
gene id: 9595:LAPTM4A
uniprot id: G3S021
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9595:RARS1
gene id: 9595:RARS1
uniprot id: G3R2H6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:PZP
gene id: 9595:PZP
uniprot id: G3QT15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9595:N6AMT1
gene id: 9595:N6AMT1
uniprot id: G3SK75
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

9595:FABP9
gene id: 9595:FABP9
uniprot id: A0A2I2ZN75
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:EHHADH
gene id: 9595:EHHADH
uniprot id: G3QXJ1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9595:AGK
gene id: 9595:AGK
uniprot id: G3RRX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9595:LOC101131162
gene id: 9595:LOC101131162
uniprot id: G3SKD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:POLR3B
gene id: 9595:POLR3B
uniprot id: A0A2I2Z996
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9595:GET3
gene id: 9595:GET3
uniprot id: G3QS12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9595:SLC25A14
gene id: 9595:SLC25A14
uniprot id: A0A2I2YE07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:LCE5A
gene id: 9595:LCE5A
uniprot id: G3S955
names: Similarity
messages: Belongs to the LCE family.

9595:EIF5B
gene id: 9595:EIF5B
uniprot id: A0A2I2Z5P7
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

9595:REC8
gene id: 9595:REC8
uniprot id: G3RIZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9595:GUCY2D
gene id: 9595:GUCY2D
uniprot id: G3REJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9595:GTPBP10
gene id: 9595:GTPBP10
uniprot id: G3SKK6
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9595:FGF10
gene id: 9595:FGF10
uniprot id: G3QPQ1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:SIM1
gene id: 9595:SIM1
uniprot id: G3RLN9
names: Subcellular Location Annotation
messages: Nucleus

9595:XPOT
gene id: 9595:XPOT
uniprot id: G3S3K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9595:RPL34
gene id: 9595:RPL34
uniprot id: G3QXE1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9595:GTPBP8
gene id: 9595:GTPBP8
uniprot id: G3RSD1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9595:EDIL3
gene id: 9595:EDIL3
uniprot id: A0A2I2Y2T5
uniprot id: A0A2I2Y8W9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:OGFOD1
gene id: 9595:OGFOD1
uniprot id: G3QIW9
names: Similarity
messages: Belongs to the TPA1 family.

9595:CLK2
gene id: 9595:CLK2
uniprot id: G3R1Y8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:ATP6V1G3
gene id: 9595:ATP6V1G3
uniprot id: G3QZQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9595:LDHAL6B
gene id: 9595:LDHAL6B
uniprot id: G3S7D5
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9595:CFAP107
gene id: 9595:CFAP107
uniprot id: G3RCP7
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9595:MHC-DMB
gene id: 9595:MHC-DMB
uniprot id: G3RQJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MHC class I family.
messages: Endosome membrane
messages: Lysosome membrane

9595:RPS19
gene id: 9595:RPS19
uniprot id: G3RGZ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

9595:DNASE2
gene id: 9595:DNASE2
uniprot id: G3QLI8
names: Similarity
messages: Belongs to the DNase II family.

9595:APOL2
gene id: 9595:APOL2
uniprot id: G3S662
names: Similarity
messages: Belongs to the apolipoprotein L family.

9595:RTN4IP1
gene id: 9595:RTN4IP1
uniprot id: G3QYX1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9595:THOC6
gene id: 9595:THOC6
uniprot id: G3QR25
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9595:LHPP
gene id: 9595:LHPP
uniprot id: A0A2I2YBY1
uniprot id: A0A2I2Z6I8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9595:UBLCP1
gene id: 9595:UBLCP1
uniprot id: G3RF15
names: Subcellular Location Annotation
messages: Nucleus

9595:GREM2
gene id: 9595:GREM2
uniprot id: A0A2I2ZEZ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:LOC101142669
gene id: 9595:LOC101142669
uniprot id: G3S373
names: Similarity
messages: Belongs to the Gfa family.

9595:SLC39A8
gene id: 9595:SLC39A8
uniprot id: G3QK74
names: Subcellular Location Annotation
messages: Membrane

9595:PDE6A
gene id: 9595:PDE6A
uniprot id: G3R565
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9595:GLYCTK
gene id: 9595:GLYCTK
uniprot id: G3RIE9
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9595:LOC101133451
gene id: 9595:LOC101133451
uniprot id: G3RZU2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Membrane
messages: Mitochondrion inner membrane

9595:RPS7
gene id: 9595:RPS7
uniprot id: G3S299
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: centrosome

9595:SUV39H2
gene id: 9595:SUV39H2
uniprot id: A0A2I2ZQ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9595:RDH10
gene id: 9595:RDH10
uniprot id: A0A2I2Y821
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9595:HSPB8
gene id: 9595:HSPB8
uniprot id: G3RC33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9595:ALOX5AP
gene id: 9595:ALOX5AP
uniprot id: G3RDC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:EID2B
gene id: 9595:EID2B
uniprot id: G3RD06
names: Subcellular Location Annotation
messages: Nucleus

9595:ANK1
gene id: 9595:ANK1
uniprot id: A0A2I2YQD4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9595:IL1A
gene id: 9595:IL1A
uniprot id: G3QLV0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Secreted

9595:TMEM150A
gene id: 9595:TMEM150A
uniprot id: A0A2I2ZPR5
uniprot id: G3QQI7
names: Subcellular Location Annotation
messages: Membrane

9595:AKR1C3
gene id: 9595:AKR1C3
uniprot id: G3QKE2
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9595:PNOC
gene id: 9595:PNOC
uniprot id: G3RI49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9595:GPC4
gene id: 9595:GPC4
uniprot id: G3QDB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9595:LOC101141797
gene id: 9595:LOC101141797
uniprot id: G3RAE9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:DPF2
gene id: 9595:DPF2
uniprot id: G3S920
names: Similarity
messages: Belongs to the requiem/DPF family.

9595:PPIE
gene id: 9595:PPIE
uniprot id: A0A2I2YPM6
uniprot id: A0A2I2ZKE5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

9595:LOXL2
gene id: 9595:LOXL2
uniprot id: G3RD94
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9595:DYNC2LI1
gene id: 9595:DYNC2LI1
uniprot id: G3SFZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9595:DNMT3B
gene id: 9595:DNMT3B
uniprot id: G3R276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9595:THBS1
gene id: 9595:THBS1
uniprot id: G3RB36
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:VPS37A
gene id: 9595:VPS37A
uniprot id: G3R7M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9595:FAM219A
gene id: 9595:FAM219A
uniprot id: A0A2I2YKP2
names: Similarity
messages: Belongs to the FAM219 family.

9595:SLC25A33
gene id: 9595:SLC25A33
uniprot id: G3S184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:SYNE4
gene id: 9595:SYNE4
uniprot id: G3QF10
names: Similarity
messages: Belongs to the nesprin family.

9595:PTPN4
gene id: 9595:PTPN4
uniprot id: G3QKS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9595:PITPNM2
gene id: 9595:PITPNM2
uniprot id: G3QDZ6
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9595:FLOT1
gene id: 9595:FLOT1
uniprot id: G3QIQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9595:MTF2
gene id: 9595:MTF2
uniprot id: G3QG43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9595:DLX4
gene id: 9595:DLX4
uniprot id: G3RG88
names: Subcellular Location Annotation
messages: Nucleus

9595:CDK7
gene id: 9595:CDK7
uniprot id: G3RC03
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9595:PPP3CB
gene id: 9595:PPP3CB
uniprot id: A0A2I2Y6B3
uniprot id: G3SGD5
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9595:FGF17
gene id: 9595:FGF17
uniprot id: G3QVX3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:DRAM1
gene id: 9595:DRAM1
uniprot id: A0A2I2YWQ6
names: Subcellular Location Annotation
messages: Membrane

9595:ST8SIA3
gene id: 9595:ST8SIA3
uniprot id: A0A2I2YE49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:C17H5orf22
gene id: 9595:C17H5orf22
uniprot id: G3R615
names: Similarity
messages: Belongs to the UPF0489 family.

9595:FH
gene id: 9595:FH
uniprot id: G3R3D3
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9595:HMGN5
gene id: 9595:HMGN5
uniprot id: G3RK21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9595:PLP1
gene id: 9595:PLP1
uniprot id: G3RK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9595:MS4A7
gene id: 9595:MS4A7
uniprot id: G3QH32
names: Similarity
messages: Belongs to the MS4A family.

9595:APOA5
gene id: 9595:APOA5
uniprot id: G3QEG1
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9595:SNAP23
gene id: 9595:SNAP23
uniprot id: G3RIB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9595:PPIL2
gene id: 9595:PPIL2
uniprot id: G3R2W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9595:EVL
gene id: 9595:EVL
uniprot id: A0A2I2ZBT4
uniprot id: G3QSW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9595:LOC101136685
gene id: 9595:LOC101136685
uniprot id: G3RR33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ZNF263
gene id: 9595:ZNF263
uniprot id: G3R4K3
names: Subcellular Location Annotation
messages: Nucleus

9595:SNPH
gene id: 9595:SNPH
uniprot id: G3QLF8
names: Subcellular Location Annotation
messages: Membrane

9595:SNCA
gene id: 9595:SNCA
uniprot id: P61140
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
messages: Belongs to the synuclein family.
messages: Cytoplasm
messages: Membrane
messages: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
messages: Nucleus
messages: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress.
messages: Secreted
messages: Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).
messages: Synapse
messages: Ubiquitinated. The predominant conjugate is the diubiquitinated form.
messages: axon

9595:FLNB
gene id: 9595:FLNB
uniprot id: G3R3J2
uniprot id: G3RYC3
names: Similarity
messages: Belongs to the filamin family.

9595:RAB4A
gene id: 9595:RAB4A
uniprot id: G3RI48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9595:CEP57
gene id: 9595:CEP57
uniprot id: A0A2I2YKN5
uniprot id: A0A2I2YYV5
uniprot id: G3RC67
names: Similarity
messages: Belongs to the translokin family.

9595:MTFMT
gene id: 9595:MTFMT
uniprot id: G3QFN0
names: Similarity
messages: Belongs to the Fmt family.

9595:KHDC1
gene id: 9595:KHDC1
uniprot id: G3QVH6
names: Similarity
messages: Belongs to the KHDC1 family.

9595:HENMT1
gene id: 9595:HENMT1
uniprot id: G3RVN4
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9595:TPD52L3
gene id: 9595:TPD52L3
uniprot id: A0A2I2YIA0
names: Similarity
messages: Belongs to the TPD52 family.

9595:DOCK5
gene id: 9595:DOCK5
uniprot id: G3QP98
names: Similarity
messages: Belongs to the DOCK family.

9595:ZDHHC17
gene id: 9595:ZDHHC17
uniprot id: G3SEE3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9595:LOC101152908
gene id: 9595:LOC101152908
uniprot id: G3QU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TSHB
gene id: 9595:TSHB
uniprot id: G3R4D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9595:SEC11A
gene id: 9595:SEC11A
uniprot id: A0A2I2ZMW9
uniprot id: G3R6A5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:SLC30A4
gene id: 9595:SLC30A4
uniprot id: G3RHA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9595:RNF34
gene id: 9595:RNF34
uniprot id: G3SFL8
names: Subcellular Location Annotation
messages: Cell membrane
messages: cytosol

9595:TMEM205
gene id: 9595:TMEM205
uniprot id: G3RE74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9595:ALDH9A1
gene id: 9595:ALDH9A1
uniprot id: G3QF25
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9595:ACSM4
gene id: 9595:ACSM4
uniprot id: G3QL84
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:PCNX3
gene id: 9595:PCNX3
uniprot id: G3SFE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9595:CLDN2
gene id: 9595:CLDN2
uniprot id: A0A2I2Y2X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:RIBC1
gene id: 9595:RIBC1
uniprot id: G3RW36
names: Similarity
messages: Belongs to the RIB43A family.

9595:VGLL1
gene id: 9595:VGLL1
uniprot id: G3QUK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9595:ATRNL1
gene id: 9595:ATRNL1
uniprot id: G3SGZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PVALB
gene id: 9595:PVALB
uniprot id: G3RTP2
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9595:GHRL
gene id: 9595:GHRL
uniprot id: A0A2I2ZBQ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
messages: O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
messages: Secreted

9595:UBE2T
gene id: 9595:UBE2T
uniprot id: G3QQW9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:TRMT61A
gene id: 9595:TRMT61A
uniprot id: G3RSR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9595:CCDC90B
gene id: 9595:CCDC90B
uniprot id: A0A2I2Y288
names: Similarity
messages: Belongs to the CCDC90 family.

9595:B4GALNT2
gene id: 9595:B4GALNT2
uniprot id: G3RSS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

9595:LSM2
gene id: 9595:LSM2
uniprot id: G3R6X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9595:SEC61B
gene id: 9595:SEC61B
uniprot id: G3QNK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9595:NUDT2
gene id: 9595:NUDT2
uniprot id: G3QMT3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9595:CCNH
gene id: 9595:CCNH
uniprot id: A0A2I2ZGP3
uniprot id: G3QR33
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9595:TPRX2
gene id: 9595:TPRX2
uniprot id: A0A2I2YFL3
names: Subcellular Location Annotation
messages: Nucleus

9595:SPSB4
gene id: 9595:SPSB4
uniprot id: G3R7A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9595:SCARA5
gene id: 9595:SCARA5
uniprot id: G3QHJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9595:GTF2H3
gene id: 9595:GTF2H3
uniprot id: G3R1B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9595:VOPP1
gene id: 9595:VOPP1
uniprot id: G3RP07
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Endosome membrane
messages: Interacts with WWOX (via WW domain).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9595:LOC101138012
gene id: 9595:LOC101138012
uniprot id: G3RDN2
names: Subcellular Location Annotation
messages: Membrane

9595:GNAI1
gene id: 9595:GNAI1
uniprot id: G3QYF3
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9595:IBSP
gene id: 9595:IBSP
uniprot id: G3QVT7
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9595:FAM118A
gene id: 9595:FAM118A
uniprot id: G3QH63
names: Similarity
messages: Belongs to the FAM118 family.

9595:EXOSC7
gene id: 9595:EXOSC7
uniprot id: G3RCD6
names: Subcellular Location Annotation
messages: Cytoplasm

9595:ACSS3
gene id: 9595:ACSS3
uniprot id: G3R3N2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9595:LOC101142266
gene id: 9595:LOC101142266
uniprot id: A0A2I2YQV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:CHD3
gene id: 9595:CHD3
uniprot id: G3RCF2
uniprot id: G3SAS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9595:COQ3
gene id: 9595:COQ3
uniprot id: G3QUZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9595:KIF13B
gene id: 9595:KIF13B
uniprot id: G3RMN3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:MS4A8
gene id: 9595:MS4A8
uniprot id: G3QDB4
names: Similarity
messages: Belongs to the MS4A family.

9595:PPM1A
gene id: 9595:PPM1A
uniprot id: G3R3K7
uniprot id: G3SHN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9595:HDC
gene id: 9595:HDC
uniprot id: A0A2I2YH58
uniprot id: G3S6Z9
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9595:CLDN19
gene id: 9595:CLDN19
uniprot id: A0A2I2YS39
uniprot id: G3QSH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:NR1H4
gene id: 9595:NR1H4
uniprot id: A0A2I2Y976
uniprot id: G3QYL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9595:CELSR3
gene id: 9595:CELSR3
uniprot id: A0A2I2YG79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

9595:NLN
gene id: 9595:NLN
uniprot id: A0A2I2ZDD9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9595:DDAH2
gene id: 9595:DDAH2
uniprot id: G3R6S1
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9595:ABCD3
gene id: 9595:ABCD3
uniprot id: G3SJ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9595:L3HYPDH
gene id: 9595:L3HYPDH
uniprot id: G3QJ41
names: Similarity
messages: Belongs to the proline racemase family.

9595:MED15
gene id: 9595:MED15
uniprot id: G3QNJ0
uniprot id: G3S027
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:FZD3
gene id: 9595:FZD3
uniprot id: G3RNY6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:HS3ST5
gene id: 9595:HS3ST5
uniprot id: G3QFL4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:TXNL4B
gene id: 9595:TXNL4B
uniprot id: A0A2I2Y9F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9595:CRHR2
gene id: 9595:CRHR2
uniprot id: A0A2I2YXL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

9595:FAM32A
gene id: 9595:FAM32A
uniprot id: G3S291
names: Similarity
messages: Belongs to the FAM32 family.

9595:TOP2A
gene id: 9595:TOP2A
uniprot id: G3S3V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9595:DEFB119
gene id: 9595:DEFB119
uniprot id: A4H225
uniprot id: G3QRK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:TNS3
gene id: 9595:TNS3
uniprot id: G3QLN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9595:LMNB1
gene id: 9595:LMNB1
uniprot id: G3RWL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9595:ILVBL
gene id: 9595:ILVBL
uniprot id: G3R4U1
names: Similarity
messages: Belongs to the TPP enzyme family.

9595:NSFL1C
gene id: 9595:NSFL1C
uniprot id: G3SJI5
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9595:GAD1
gene id: 9595:GAD1
uniprot id: A0A2I2ZG24
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9595:LOC101133483
gene id: 9595:LOC101133483
uniprot id: G3REG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9595:CFAP97
gene id: 9595:CFAP97
uniprot id: G3QX24
names: Similarity
messages: Belongs to the CFAP97 family.

9595:SIAH2
gene id: 9595:SIAH2
uniprot id: G3RFD5
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9595:AKT2
gene id: 9595:AKT2
uniprot id: A0A2I2YDQ0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9595:RHO
gene id: 9595:RHO
uniprot id: G3R589
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane

9595:SGK2
gene id: 9595:SGK2
uniprot id: G3SEL5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:SLC25A17
gene id: 9595:SLC25A17
uniprot id: G3S3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:GJA3
gene id: 9595:GJA3
uniprot id: G3QHB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:HOATZ
gene id: 9595:HOATZ
uniprot id: G3SE45
names: Similarity
messages: Belongs to the HOATZ family.

9595:LIMK2
gene id: 9595:LIMK2
uniprot id: A0A2I2YHM5
uniprot id: A0A2I2ZVF0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9595:SPCS3
gene id: 9595:SPCS3
uniprot id: G3RWD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:LOC101151363
gene id: 9595:LOC101151363
uniprot id: G3RC14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:IL37
gene id: 9595:IL37
uniprot id: A0A2I2YI20
uniprot id: A0A2I2ZTH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9595:FOXR2
gene id: 9595:FOXR2
uniprot id: G3QYV6
names: Subcellular Location Annotation
messages: Nucleus

9595:DGCR6
gene id: 9595:DGCR6
uniprot id: G3RKM5
names: Similarity
messages: Belongs to the gonadal family.

9595:PUS1
gene id: 9595:PUS1
uniprot id: G3R1B2
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9595:DSG1
gene id: 9595:DSG1
uniprot id: G3QD33
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9595:CRABP1
gene id: 9595:CRABP1
uniprot id: G3R4H6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:MSMB
gene id: 9595:MSMB
uniprot id: G3RFU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9595:SCD
gene id: 9595:SCD
uniprot id: G3QFK6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9595:NDOR1
gene id: 9595:NDOR1
uniprot id: A0A2I2ZSH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.
messages: perinuclear region

9595:TGFB2
gene id: 9595:TGFB2
uniprot id: A0A2I2ZKR7
uniprot id: G3QPK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9595:RXFP2
gene id: 9595:RXFP2
uniprot id: G3QJL3
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:DLG1
gene id: 9595:DLG1
uniprot id: A0A2I2Y8U0
uniprot id: G3QH48
uniprot id: G3QQG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9595:LOC129523523
gene id: 9595:LOC129523523
uniprot id: G3QHW8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9595:SLC17A6
gene id: 9595:SLC17A6
uniprot id: G3RL78
names: Subcellular Location Annotation
messages: Membrane

9595:CDIPT
gene id: 9595:CDIPT
uniprot id: G3RHV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9595:CPLX2
gene id: 9595:CPLX2
uniprot id: A0A2I2Y633
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9595:RDH8
gene id: 9595:RDH8
uniprot id: G3R961
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

9595:SLC66A1
gene id: 9595:SLC66A1
uniprot id: G3QE42
names: Subcellular Location Annotation
messages: Membrane

9595:ATP11A
gene id: 9595:ATP11A
uniprot id: A0A2I2YUM4
uniprot id: G3RQB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9595:LOC101126229
gene id: 9595:LOC101126229
uniprot id: G3QPJ0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:CLDN3
gene id: 9595:CLDN3
uniprot id: G3S2W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:LIX1L
gene id: 9595:LIX1L
uniprot id: G3RMP0
names: Similarity
messages: Belongs to the LIX1 family.

9595:PRICKLE1
gene id: 9595:PRICKLE1
uniprot id: G3S2Z9
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9595:TPRKB
gene id: 9595:TPRKB
uniprot id: G3S8Z0
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9595:MAGI1
gene id: 9595:MAGI1
uniprot id: A0A2I2ZL88
uniprot id: G3SCC1
names: Subcellular Location Annotation
messages: Membrane

9595:OSBPL1A
gene id: 9595:OSBPL1A
uniprot id: G3QTD4
uniprot id: G3SJJ5
names: Similarity
messages: Belongs to the OSBP family.

9595:GINS2
gene id: 9595:GINS2
uniprot id: G3RNK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9595:ST3GAL6
gene id: 9595:ST3GAL6
uniprot id: G3RLE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:PWP2
gene id: 9595:PWP2
uniprot id: A0A2I2ZNH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9595:ADCK2
gene id: 9595:ADCK2
uniprot id: G3R9E7
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9595:GIPC2
gene id: 9595:GIPC2
uniprot id: G3QQL5
names: Similarity
messages: Belongs to the GIPC family.

9595:LOC101136183
gene id: 9595:LOC101136183
uniprot id: A0A2I2Z6M2
names: Subcellular Location Annotation
messages: Membrane

9595:SUSD2
gene id: 9595:SUSD2
uniprot id: G3QHN9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:C2BH2orf88
gene id: 9595:C2BH2orf88
uniprot id: G3S0Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9595:MFSD6L
gene id: 9595:MFSD6L
uniprot id: G3QT10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9595:BAX
gene id: 9595:BAX
uniprot id: G3RTU9
names: Similarity
messages: Belongs to the Bcl-2 family.

9595:AURKC
gene id: 9595:AURKC
uniprot id: G3QY90
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

9595:ADGRE5
gene id: 9595:ADGRE5
uniprot id: A0A2I2YIG6
uniprot id: A0A2I2YJG6
uniprot id: A0A2I2ZX84
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SLC19A2
gene id: 9595:SLC19A2
uniprot id: G3SC76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9595:NPPA
gene id: 9595:NPPA
uniprot id: G3RAZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9595:ANXA1
gene id: 9595:ANXA1
uniprot id: G3QPT3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9595:TGM1
gene id: 9595:TGM1
uniprot id: G3RJ54
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9595:NMS
gene id: 9595:NMS
uniprot id: G3RV46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9595:CDH9
gene id: 9595:CDH9
uniprot id: G3R9J0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:ERC1
gene id: 9595:ERC1
uniprot id: A0A2I2Y258
uniprot id: A0A2I2Y2U7
names: Subcellular Location Annotation
messages: Cytoplasm

9595:NAGA
gene id: 9595:NAGA
uniprot id: G3QXZ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9595:MRPL16
gene id: 9595:MRPL16
uniprot id: G3S6I0
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9595:FABP1
gene id: 9595:FABP1
uniprot id: G3R258
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9595:SPARCL1
gene id: 9595:SPARCL1
uniprot id: G3RHD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9595:ZNF768
gene id: 9595:ZNF768
uniprot id: G3SGB9
names: Subcellular Location Annotation
messages: Nucleus

9595:ADAM15
gene id: 9595:ADAM15
uniprot id: A0A2I2YJI0
uniprot id: A0A2I2YLZ1
uniprot id: A0A2I2ZX51
uniprot id: G3RDF4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TRIM5
gene id: 9595:TRIM5
uniprot id: Q5C8T6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation (By similarity).
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
messages: Cytoplasm
messages: Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.
messages: Nucleus
messages: The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity. The coiled coil domain is important for higher order multimerization by promoting the initial dimerization.
messages: The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs (By similarity).
messages: The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization.

9595:LOC101150369
gene id: 9595:LOC101150369
uniprot id: G3SKC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9595:GSDMB
gene id: 9595:GSDMB
uniprot id: A0A2I2YG62
uniprot id: G3QZ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9595:CLDN24
gene id: 9595:CLDN24
uniprot id: G3RZ65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:UNC45A
gene id: 9595:UNC45A
uniprot id: G3QYT2
names: Subcellular Location Annotation
messages: perinuclear region

9595:RNF121
gene id: 9595:RNF121
uniprot id: G3SB30
names: Subcellular Location Annotation
messages: Membrane

9595:FXN
gene id: 9595:FXN
uniprot id: A0A2I2ZHU2
names: Similarity
messages: Belongs to the frataxin family.

9595:TPM4
gene id: 9595:TPM4
uniprot id: A0A2I2YC45
uniprot id: A0A2I2Z1M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9595:EZH2
gene id: 9595:EZH2
uniprot id: G3S979
names: Subcellular Location Annotation
messages: Nucleus

9595:MORF4L1
gene id: 9595:MORF4L1
uniprot id: G3RM80
uniprot id: G3RY52
names: Subcellular Location Annotation
messages: Nucleus

9595:RAD54L2
gene id: 9595:RAD54L2
uniprot id: G3R3H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9595:NDUFA7
gene id: 9595:NDUFA7
uniprot id: G3QF48
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9595:TRAK1
gene id: 9595:TRAK1
uniprot id: G3QHQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9595:CHL1
gene id: 9595:CHL1
uniprot id: G3R020
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9595:OXCT1
gene id: 9595:OXCT1
uniprot id: G3S0S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9595:SLC4A9
gene id: 9595:SLC4A9
uniprot id: G3QDG4
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9595:TRIAP1
gene id: 9595:TRIAP1
uniprot id: G3RR18
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9595:SERPINA6
gene id: 9595:SERPINA6
uniprot id: G3QXY9
names: Similarity
messages: Belongs to the serpin family.

9595:ICAM4
gene id: 9595:ICAM4
uniprot id: G3QT47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9595:LLPH
gene id: 9595:LLPH
uniprot id: G3SJL3
names: Similarity
messages: Belongs to the learning-associated protein family.

9595:CDC14B
gene id: 9595:CDC14B
uniprot id: G3R0U4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9595:ANAPC5
gene id: 9595:ANAPC5
uniprot id: G3QZZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9595:BPIFB2
gene id: 9595:BPIFB2
uniprot id: G3R502
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9595:TRIQK
gene id: 9595:TRIQK
uniprot id: A0A2I2Y3I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:GABRB2
gene id: 9595:GABRB2
uniprot id: A0A2I2YKJ9
uniprot id: G3RF14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:BLVRA
gene id: 9595:BLVRA
uniprot id: A0A2I2Z6L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

9595:LOC101145725
gene id: 9595:LOC101145725
uniprot id: A0A2I2ZKL9
names: Similarity
messages: Belongs to the PRAME family.

9595:PPRC1
gene id: 9595:PPRC1
uniprot id: A0A2I2YUV5
uniprot id: A0A2I2ZSY4
uniprot id: G3QIB7
names: Subcellular Location Annotation
messages: Nucleus

9595:SERPINE1
gene id: 9595:SERPINE1
uniprot id: G3QW76
names: Similarity
messages: Belongs to the serpin family.

9595:C8A
gene id: 9595:C8A
uniprot id: G3RDM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9595:CHAC1
gene id: 9595:CHAC1
uniprot id: G3SI09
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9595:FLI1
gene id: 9595:FLI1
uniprot id: A0A2I2ZEQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9595:PEX2
gene id: 9595:PEX2
uniprot id: A0A2I2Z8W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9595:SLC25A18
gene id: 9595:SLC25A18
uniprot id: G3RGB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:SUB1
gene id: 9595:SUB1
uniprot id: A0A2I2YAN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9595:GJB5
gene id: 9595:GJB5
uniprot id: G3R0Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:DAG1
gene id: 9595:DAG1
uniprot id: G3R897
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9595:IL7
gene id: 9595:IL7
uniprot id: A0A2I2Y631
uniprot id: A0A2I2YQZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Interacts with IL7R and CSF2RG.
messages: Secreted

9595:NAALADL1
gene id: 9595:NAALADL1
uniprot id: A0A2I2YMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9595:CCNE2
gene id: 9595:CCNE2
uniprot id: G3RG37
names: Similarity
messages: Belongs to the cyclin family.

9595:COQ5
gene id: 9595:COQ5
uniprot id: G3R0B6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9595:SLC2A9
gene id: 9595:SLC2A9
uniprot id: A0A2I2ZP61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane

9595:SLC17A7
gene id: 9595:SLC17A7
uniprot id: G3RKG3
names: Subcellular Location Annotation
messages: Membrane

9595:CCL21
gene id: 9595:CCL21
uniprot id: G3S8M0
names: Subcellular Location Annotation
messages: Secreted

9595:RPL15
gene id: 9595:RPL15
uniprot id: G3SD81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

9595:VAPB
gene id: 9595:VAPB
uniprot id: A0A2I2YJ68
uniprot id: G3QXS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:BTAF1
gene id: 9595:BTAF1
uniprot id: G3S6X7
names: Subcellular Location Annotation
messages: Nucleus

9595:TMPRSS4
gene id: 9595:TMPRSS4
uniprot id: G3SF67
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC109028241
gene id: 9595:LOC109028241
uniprot id: G3RM01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:TLR7
gene id: 9595:TLR7
uniprot id: G3RXT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9595:LVRN
gene id: 9595:LVRN
uniprot id: G3QWK5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9595:CDH19
gene id: 9595:CDH19
uniprot id: G3S948
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:EMP3
gene id: 9595:EMP3
uniprot id: G3RGJ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9595:FTSJ1
gene id: 9595:FTSJ1
uniprot id: G3SK06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

9595:TMEM30A
gene id: 9595:TMEM30A
uniprot id: G3QLR5
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9595:IWS1
gene id: 9595:IWS1
uniprot id: G3R4F3
names: Subcellular Location Annotation
messages: Nucleus

9595:CEP43
gene id: 9595:CEP43
uniprot id: A0A2I2ZG60
uniprot id: A0A2I2ZH15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9595:G0S2
gene id: 9595:G0S2
uniprot id: A0A2I2Z078
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.
messages: Mitochondrion
messages: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

9595:EMP1
gene id: 9595:EMP1
uniprot id: G3SHA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9595:ARHGEF2
gene id: 9595:ARHGEF2
uniprot id: G3SHS4
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

9595:LOC101146459
gene id: 9595:LOC101146459
uniprot id: G3S9G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ACTBL2
gene id: 9595:ACTBL2
uniprot id: A0A2I2ZEN8
names: Similarity
messages: Belongs to the actin family.

9595:PHACTR2
gene id: 9595:PHACTR2
uniprot id: A0A2I2Z3J2
uniprot id: A0A2I2ZNH1
uniprot id: G3RSU5
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9595:HTR2A
gene id: 9595:HTR2A
uniprot id: A0A2I2YKA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

9595:B3GALT2
gene id: 9595:B3GALT2
uniprot id: G3S7A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:ASIP
gene id: 9595:ASIP
uniprot id: G3SDS8
names: Subcellular Location Annotation
messages: Secreted

9595:PEX3
gene id: 9595:PEX3
uniprot id: G3RJA6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9595:NOSIP
gene id: 9595:NOSIP
uniprot id: G3QVS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

9595:LOC101137790
gene id: 9595:LOC101137790
uniprot id: G3R8R1
names: Similarity
messages: Belongs to the peptidase C14A family.

9595:GNAZ
gene id: 9595:GNAZ
uniprot id: G3RJV2
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9595:VEZT
gene id: 9595:VEZT
uniprot id: G3S6Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9595:TMEM170A
gene id: 9595:TMEM170A
uniprot id: A0A2I2YFG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9595:ZPBP
gene id: 9595:ZPBP
uniprot id: G3RKU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted
messages: acrosome

9595:CCDC85A
gene id: 9595:CCDC85A
uniprot id: G3R6Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9595:KCNJ3
gene id: 9595:KCNJ3
uniprot id: G3SFZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9595:AP3M1
gene id: 9595:AP3M1
uniprot id: G3R698
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9595:APOC1
gene id: 9595:APOC1
uniprot id: A0A2I2YNH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C1 family.
messages: Secreted

9595:MCM7
gene id: 9595:MCM7
uniprot id: A0A2I2Y544
uniprot id: G3QJU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9595:COQ10B
gene id: 9595:COQ10B
uniprot id: A0A2I2ZRA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9595:LHFPL5
gene id: 9595:LHFPL5
uniprot id: G3SGN3
names: Subcellular Location Annotation
messages: Membrane

9595:CLRN2
gene id: 9595:CLRN2
uniprot id: G3SA32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9595:NR1D2
gene id: 9595:NR1D2
uniprot id: G3QL26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9595:ANAPC13
gene id: 9595:ANAPC13
uniprot id: G3R8C4
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9595:TAPT1
gene id: 9595:TAPT1
uniprot id: G3R827
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

9595:PRKD2
gene id: 9595:PRKD2
uniprot id: A0A2I2ZRU3
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9595:DERL2
gene id: 9595:DERL2
uniprot id: A0A2I2YCV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:MAOA
gene id: 9595:MAOA
uniprot id: G3R0P3
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9595:TP63
gene id: 9595:TP63
uniprot id: A0A2I2Z434
uniprot id: A0A2I2ZLA8
uniprot id: G3QQY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Nucleus

9595:SLC5A9
gene id: 9595:SLC5A9
uniprot id: G3R8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9595:WNT2B
gene id: 9595:WNT2B
uniprot id: G3QM25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9595:NPAS1
gene id: 9595:NPAS1
uniprot id: G3RC50
names: Subcellular Location Annotation
messages: Nucleus

9595:ZNF197
gene id: 9595:ZNF197
uniprot id: A0A2I2YVE2
names: Subcellular Location Annotation
messages: Nucleus

9595:C9
gene id: 9595:C9
uniprot id: G3RIM1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9595:AMZ1
gene id: 9595:AMZ1
uniprot id: G3QK80
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9595:KHDC3L
gene id: 9595:KHDC3L
uniprot id: G3QXQ1
names: Similarity
messages: Belongs to the KHDC1 family.

9595:NFIL3
gene id: 9595:NFIL3
uniprot id: G3QG48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9595:EIF2B5
gene id: 9595:EIF2B5
uniprot id: G3QWV1
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

9595:NRXN1
gene id: 9595:NRXN1
uniprot id: A0A2I2Y2M8
uniprot id: A0A2I2ZUG4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Presynaptic cell membrane

9595:IQCD
gene id: 9595:IQCD
uniprot id: G3RNN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9595:CD5
gene id: 9595:CD5
uniprot id: G3QUT8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:MMS19
gene id: 9595:MMS19
uniprot id: G3QKT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9595:BABAM2
gene id: 9595:BABAM2
uniprot id: A0A2I2YFB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9595:ST3GAL5
gene id: 9595:ST3GAL5
uniprot id: G3S1R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9595:PHKA1
gene id: 9595:PHKA1
uniprot id: G3QV86
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9595:SERPINA12
gene id: 9595:SERPINA12
uniprot id: G3QU16
names: Similarity
messages: Belongs to the serpin family.

9595:GPR17
gene id: 9595:GPR17
uniprot id: G3QPZ8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:GHR
gene id: 9595:GHR
uniprot id: A0A2I2Y9H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

9595:ABCG5
gene id: 9595:ABCG5
uniprot id: G3QEB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9595:LOC101150488
gene id: 9595:LOC101150488
uniprot id: G3QHY0
names: Similarity
messages: Belongs to the PRAME family.

9595:CHM
gene id: 9595:CHM
uniprot id: G3RQ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9595:PLA2G2E
gene id: 9595:PLA2G2E
uniprot id: G3RCC5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9595:CDCA5
gene id: 9595:CDCA5
uniprot id: A0A2I2YL62
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9595:MRPL34
gene id: 9595:MRPL34
uniprot id: G3QSN3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

9595:HADH
gene id: 9595:HADH
uniprot id: G3QP50
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9595:SMIM22
gene id: 9595:SMIM22
uniprot id: A0A2I2YEH1
names: Subcellular Location Annotation
messages: Membrane

9595:PAPSS1
gene id: 9595:PAPSS1
uniprot id: G3RFL2
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9595:MOB1A
gene id: 9595:MOB1A
uniprot id: G3S3V8
names: Similarity
messages: Belongs to the MOB1/phocein family.

9595:UTP15
gene id: 9595:UTP15
uniprot id: A0A2I2ZXL7
names: Subcellular Location Annotation
messages: nucleolus

9595:ACY3
gene id: 9595:ACY3
uniprot id: G3R8H3
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9595:PPFIA1
gene id: 9595:PPFIA1
uniprot id: A0A2I2YW20
uniprot id: A0A2I2ZKM7
uniprot id: G3RBT5
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9595:LOC101137471
gene id: 9595:LOC101137471
uniprot id: G3S0Z6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9595:LOC101136413
gene id: 9595:LOC101136413
uniprot id: G3RLF1
names: Subcellular Location Annotation
messages: Membrane

9595:SOD1
gene id: 9595:SOD1
uniprot id: A0A2I2Z7B3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

9595:BMPR1B
gene id: 9595:BMPR1B
uniprot id: G3R8S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9595:MMP9
gene id: 9595:MMP9
uniprot id: G3RCL1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

9595:C18H18orf21
gene id: 9595:C18H18orf21
uniprot id: A0A2I2YMY3
names: Similarity
messages: Belongs to the UPF0711 family.

9595:MIPEP
gene id: 9595:MIPEP
uniprot id: G3R1X7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9595:PELO
gene id: 9595:PELO
uniprot id: G3RA63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
messages: Cytoplasm

9595:LCAT
gene id: 9595:LCAT
uniprot id: G3QQL2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9595:TMEM150B
gene id: 9595:TMEM150B
uniprot id: G3QDZ7
names: Subcellular Location Annotation
messages: Membrane

9595:RRS1
gene id: 9595:RRS1
uniprot id: G3RU40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9595:LIN28A
gene id: 9595:LIN28A
uniprot id: A0A2I2ZBW7
names: Similarity
messages: Belongs to the lin-28 family.

9595:CMTR1
gene id: 9595:CMTR1
uniprot id: G3QSA2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9595:ASB13
gene id: 9595:ASB13
uniprot id: G3QDY4
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9595:RAB14
gene id: 9595:RAB14
uniprot id: G3S102
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9595:RPP30
gene id: 9595:RPP30
uniprot id: G3RXX6
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9595:CMKLR1
gene id: 9595:CMKLR1
uniprot id: G3R3P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9595:SLC25A38
gene id: 9595:SLC25A38
uniprot id: G3RCH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9595:EIF4E2
gene id: 9595:EIF4E2
uniprot id: A0A2I2Z113
uniprot id: A0A2I2ZEB1
uniprot id: A0A2I2ZKU3
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9595:LOC101150976
gene id: 9595:LOC101150976
uniprot id: G3R6Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9595:PEX5L
gene id: 9595:PEX5L
uniprot id: A0A2I2YCR6
uniprot id: A0A2I2YTV2
uniprot id: A0A2I2ZH83
uniprot id: A0A2I2ZU12
uniprot id: G3QKH7
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9595:TSPAN4
gene id: 9595:TSPAN4
uniprot id: G3R5H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:PHTF2
gene id: 9595:PHTF2
uniprot id: G3S236
names: Subcellular Location Annotation
messages: Membrane

9595:IDH2
gene id: 9595:IDH2
uniprot id: G3QQB8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.

9595:LOC101141137
gene id: 9595:LOC101141137
uniprot id: G3QV65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ATP5PO
gene id: 9595:ATP5PO
uniprot id: G3RA47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9595:SDHAF1
gene id: 9595:SDHAF1
uniprot id: G3R6P0
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9595:FAM76B
gene id: 9595:FAM76B
uniprot id: G3RC57
names: Similarity
messages: Belongs to the FAM76 family.

9595:DTNB
gene id: 9595:DTNB
uniprot id: A0A2I2ZG45
uniprot id: A0A2I2ZKZ6
uniprot id: G3QXH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9595:CLTCL1
gene id: 9595:CLTCL1
uniprot id: G3S0H9
uniprot id: G3S7V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9595:ACO1
gene id: 9595:ACO1
uniprot id: G3RJN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

9595:RGMB
gene id: 9595:RGMB
uniprot id: G3SBT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9595:NDUFAF1
gene id: 9595:NDUFAF1
uniprot id: A0A2I2ZYF3
uniprot id: Q0MQ83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.
messages: Mitochondrion
messages: Mitochondrion matrix
messages: Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Interacts with ECSIT. Interacts with ACAD9. At early stages of complex I assembly, it is found in intermediate subcomplexes that contain different subunits including NDUFB6, NDUFA6, NDUFA9, NDUFS3, NDUFS7, ND1, ND2 and ND3. Interacts with TMEM70 and TMEM242 (By similarity).

9595:RGR
gene id: 9595:RGR
uniprot id: A0A2I2Z6P6
names: Subcellular Location Annotation
messages: Membrane

9595:TPST2
gene id: 9595:TPST2
uniprot id: G3QQN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9595:SLA2
gene id: 9595:SLA2
uniprot id: G3RAU1
names: Subcellular Location Annotation
messages: Cytoplasm

9595:TMPRSS15
gene id: 9595:TMPRSS15
uniprot id: G3QEB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMBT1 family.
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.

9595:SYP
gene id: 9595:SYP
uniprot id: G3QG14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9595:DGAT1
gene id: 9595:DGAT1
uniprot id: G3RU45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9595:LOC101143900
gene id: 9595:LOC101143900
uniprot id: G3QS82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9595:NFX1
gene id: 9595:NFX1
uniprot id: A0A2I2ZQ24
uniprot id: G3QV50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9595:LOC101126456
gene id: 9595:LOC101126456
uniprot id: G3RHD9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:MAP7D3
gene id: 9595:MAP7D3
uniprot id: A0A2I2YJK5
names: Similarity
messages: Belongs to the MAP7 family.

9595:ADAMTS16
gene id: 9595:ADAMTS16
uniprot id: G3RFX7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:ACAD9
gene id: 9595:ACAD9
uniprot id: G3R2D4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9595:MAP7
gene id: 9595:MAP7
uniprot id: A0A2I2YR22
uniprot id: A0A2I2Z0C0
names: Similarity
messages: Belongs to the MAP7 family.

9595:DNAJC22
gene id: 9595:DNAJC22
uniprot id: G3SJ05
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9595:CEBPE
gene id: 9595:CEBPE
uniprot id: G3QWU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9595:CTNNAL1
gene id: 9595:CTNNAL1
uniprot id: G3QNN9
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9595:NFIB
gene id: 9595:NFIB
uniprot id: A0A2I2ZKD3
uniprot id: G3S9D9
uniprot id: G3SIQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9595:NDUFC2
gene id: 9595:NDUFC2
uniprot id: Q0MQF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Complex I is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Mitochondrion inner membrane

9595:QTRT2
gene id: 9595:QTRT2
uniprot id: G3S8V7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9595:ARID5B
gene id: 9595:ARID5B
uniprot id: A0A2I2Z1S3
uniprot id: G3QND9
names: Similarity
messages: Belongs to the ARID5B family.

9595:RPS11
gene id: 9595:RPS11
uniprot id: G3QKB6
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9595:LOC101135314
gene id: 9595:LOC101135314
uniprot id: G3SA70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SLC16A1
gene id: 9595:SLC16A1
uniprot id: G3RHM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9595:LOC101139165
gene id: 9595:LOC101139165
uniprot id: G3RGI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9595:ARL1
gene id: 9595:ARL1
uniprot id: G3R5E4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9595:TRMT13
gene id: 9595:TRMT13
uniprot id: G3QS72
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9595:CD164
gene id: 9595:CD164
uniprot id: G3QLH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9595:CHMP7
gene id: 9595:CHMP7
uniprot id: G3QJA9
names: Similarity
messages: Belongs to the SNF7 family.

9595:ZEB2
gene id: 9595:ZEB2
uniprot id: A0A2I2Z563
uniprot id: A0A2I2ZGH3
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9595:GGT6
gene id: 9595:GGT6
uniprot id: A0A2I2YKH0
uniprot id: G3QU68
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9595:NOX3
gene id: 9595:NOX3
uniprot id: G3RI51
names: Subcellular Location Annotation
messages: Membrane

9595:KRT38
gene id: 9595:KRT38
uniprot id: G3SI50
names: Similarity
messages: Belongs to the intermediate filament family.

9595:GABRA3
gene id: 9595:GABRA3
uniprot id: G3SKG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:SLC39A7
gene id: 9595:SLC39A7
uniprot id: G3R2Y9
names: Subcellular Location Annotation
messages: Membrane

9595:FAM234A
gene id: 9595:FAM234A
uniprot id: G3RC02
names: Similarity
messages: Belongs to the FAM234 family.

9595:TJAP1
gene id: 9595:TJAP1
uniprot id: G3RGQ9
uniprot id: G3RYF0
names: Subcellular Location Annotation
messages: Membrane

9595:SLC4A1
gene id: 9595:SLC4A1
uniprot id: G3RRW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

9595:LOC101154093
gene id: 9595:LOC101154093
uniprot id: G3RH36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9595:FOLR2
gene id: 9595:FOLR2
uniprot id: G3R6P4
names: Similarity
messages: Belongs to the folate receptor family.

9595:ZNF622
gene id: 9595:ZNF622
uniprot id: G3RSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9595:PTP4A3
gene id: 9595:PTP4A3
uniprot id: A0A2I2YS06
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9595:RPL41
gene id: 9595:RPL41
uniprot id: A0A2I2YS91
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit.

9595:H1-1
gene id: 9595:H1-1
uniprot id: A0A2I2YJH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9595:NEU2
gene id: 9595:NEU2
uniprot id: G3QRW5
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9595:KCNH1
gene id: 9595:KCNH1
uniprot id: G3SKG7
names: Subcellular Location Annotation
messages: Membrane

9595:S100A2
gene id: 9595:S100A2
uniprot id: G3RYQ2
names: Similarity
messages: Belongs to the S-100 family.

9595:SUPT20H
gene id: 9595:SUPT20H
uniprot id: A0A2I2Y7K6
uniprot id: G3R8D6
uniprot id: G3SJR6
names: Similarity
messages: Belongs to the SPT20 family.

9595:BAP1
gene id: 9595:BAP1
uniprot id: G3RIK2
names: Similarity
messages: Belongs to the peptidase C12 family.

9595:FAM47B
gene id: 9595:FAM47B
uniprot id: G3QGX4
names: Similarity
messages: Belongs to the FAM47 family.

9595:KRT222
gene id: 9595:KRT222
uniprot id: G3RCY3
names: Similarity
messages: Belongs to the intermediate filament family.

9595:FAM133A
gene id: 9595:FAM133A
uniprot id: A0A2I2YMD1
names: Similarity
messages: Belongs to the FAM133 family.

9595:ST14
gene id: 9595:ST14
uniprot id: G3S550
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:DHCR7
gene id: 9595:DHCR7
uniprot id: G3QUK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9595:PROM2
gene id: 9595:PROM2
uniprot id: G3QUE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9595:GAPDH
gene id: 9595:GAPDH
uniprot id: G3R288
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9595:ILF3
gene id: 9595:ILF3
uniprot id: A0A2I2YPJ5
uniprot id: G3QNF4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:PDRG1
gene id: 9595:PDRG1
uniprot id: G3S683
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9595:CPNE6
gene id: 9595:CPNE6
uniprot id: A0A2I2YT19
names: Similarity
messages: Belongs to the copine family.

9595:RNF8
gene id: 9595:RNF8
uniprot id: G3RG85
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9595:PI4K2A
gene id: 9595:PI4K2A
uniprot id: G3RGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9595:ALKBH8
gene id: 9595:ALKBH8
uniprot id: G3RHK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

9595:ERLIN2
gene id: 9595:ERLIN2
uniprot id: A0A2I2YUD9
uniprot id: G3RAR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9595:ARL14
gene id: 9595:ARL14
uniprot id: A0A2I2ZPU2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9595:POLR2D
gene id: 9595:POLR2D
uniprot id: G3QPW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

9595:PRKAR2B
gene id: 9595:PRKAR2B
uniprot id: G3QMV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9595:PMPCB
gene id: 9595:PMPCB
uniprot id: A0A2I2ZSW3
uniprot id: G3S5I3
names: Similarity
messages: Belongs to the peptidase M16 family.

9595:KCNK4
gene id: 9595:KCNK4
uniprot id: G3RRZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9595:BTG3
gene id: 9595:BTG3
uniprot id: G3S0B1
names: Similarity
messages: Belongs to the BTG family.

9595:GBX2
gene id: 9595:GBX2
uniprot id: G3RTW1
names: Subcellular Location Annotation
messages: Nucleus

9595:VEGFD
gene id: 9595:VEGFD
uniprot id: G3QJY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9595:KITLG
gene id: 9595:KITLG
uniprot id: G3S4K2
uniprot id: G3S7Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

9595:RBM5
gene id: 9595:RBM5
uniprot id: G3REZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9595:SERPINF2
gene id: 9595:SERPINF2
uniprot id: G3S7C3
names: Similarity
messages: Belongs to the serpin family.

9595:SVEP1
gene id: 9595:SVEP1
uniprot id: G3RNE5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:DESI1
gene id: 9595:DESI1
uniprot id: A0A2I2Z916
names: Similarity
messages: Belongs to the DeSI family.

9595:PENK
gene id: 9595:PENK
uniprot id: G3RJH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9595:DENND6A
gene id: 9595:DENND6A
uniprot id: G3SKS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

9595:NKAPL
gene id: 9595:NKAPL
uniprot id: A0A2I2YR21
names: Similarity
messages: Belongs to the NKAP family.

9595:TMEM98
gene id: 9595:TMEM98
uniprot id: G3RBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9595:MCHR2
gene id: 9595:MCHR2
uniprot id: G3RLV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SMC1B
gene id: 9595:SMC1B
uniprot id: A0A2I2ZA49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9595:MADD
gene id: 9595:MADD
uniprot id: A0A2I2YVS3
uniprot id: A0A2I2Z9X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9595:NPHS2
gene id: 9595:NPHS2
uniprot id: A0A2I2YN39
uniprot id: G3RH62
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9595:RAD51D
gene id: 9595:RAD51D
uniprot id: G3QDN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

9595:GNAT3
gene id: 9595:GNAT3
uniprot id: G3R3M1
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9595:MRPL19
gene id: 9595:MRPL19
uniprot id: A0A2I2Z2F3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9595:NDUFC1
gene id: 9595:NDUFC1
uniprot id: Q0MQF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9595:WAPL
gene id: 9595:WAPL
uniprot id: G3S4Q4
names: Similarity
messages: Belongs to the WAPL family.

9595:CDC20
gene id: 9595:CDC20
uniprot id: G3R4G2
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9595:B3GAT1
gene id: 9595:B3GAT1
uniprot id: G3QIV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:MIGA2
gene id: 9595:MIGA2
uniprot id: G3RUJ6
names: Similarity
messages: Belongs to the mitoguardin family.

9595:F2
gene id: 9595:F2
uniprot id: G3QVP5
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

9595:FAM162B
gene id: 9595:FAM162B
uniprot id: G3QI16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9595:PPP1R15B
gene id: 9595:PPP1R15B
uniprot id: G3QG83
names: Similarity
messages: Belongs to the PPP1R15 family.

9595:MC5R
gene id: 9595:MC5R
uniprot id: G3RYK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

9595:DPH2
gene id: 9595:DPH2
uniprot id: G3S888
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9595:ARSG
gene id: 9595:ARSG
uniprot id: G3QG36
names: Similarity
messages: Belongs to the sulfatase family.

9595:HHATL
gene id: 9595:HHATL
uniprot id: G3QVU8
names: Subcellular Location Annotation
messages: Membrane

9595:WARS1
gene id: 9595:WARS1
uniprot id: G3R3T9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:MC4R
gene id: 9595:MC4R
uniprot id: G3RGA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9595:NQO2
gene id: 9595:NQO2
uniprot id: A0A2I2YLC9
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9595:LOC101127305
gene id: 9595:LOC101127305
uniprot id: A0A2I2Z4J5
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9595:SGTB
gene id: 9595:SGTB
uniprot id: G3S4B3
names: Similarity
messages: Belongs to the SGT family.

9595:EPHX1
gene id: 9595:EPHX1
uniprot id: G3QEY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9595:LOC101148837
gene id: 9595:LOC101148837
uniprot id: G3S8Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PCLO
gene id: 9595:PCLO
uniprot id: G3QNK0
names: Subcellular Location Annotation
messages: Presynaptic active zone

9595:NMU
gene id: 9595:NMU
uniprot id: A0A2I2YNU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9595:PAH
gene id: 9595:PAH
uniprot id: G3S964
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9595:EXOC6B
gene id: 9595:EXOC6B
uniprot id: G3QDX8
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9595:CUZD1
gene id: 9595:CUZD1
uniprot id: G3QW82
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PRPF4
gene id: 9595:PRPF4
uniprot id: G3QVM3
names: Subcellular Location Annotation
messages: Nucleus speckle

9595:PPM1N
gene id: 9595:PPM1N
uniprot id: G3QCS8
names: Similarity
messages: Belongs to the PP2C family.

9595:KATNB1
gene id: 9595:KATNB1
uniprot id: G3QW37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9595:CSF2
gene id: 9595:CSF2
uniprot id: G3QFF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9595:TMEM225
gene id: 9595:TMEM225
uniprot id: G3RK89
names: Subcellular Location Annotation
messages: Membrane

9595:ACAA1
gene id: 9595:ACAA1
uniprot id: G3QML6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9595:KIF20B
gene id: 9595:KIF20B
uniprot id: G3QED3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:TWF1
gene id: 9595:TWF1
uniprot id: G3QSD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9595:LOC101141751
gene id: 9595:LOC101141751
uniprot id: G3RM71
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9595:PREPL
gene id: 9595:PREPL
uniprot id: G3QWD0
names: Similarity
messages: Belongs to the peptidase S9A family.

9595:CSNK1E
gene id: 9595:CSNK1E
uniprot id: A0A2I2YDN8
uniprot id: A0A2I2ZQ55
uniprot id: G3RJC8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:PTGS2
gene id: 9595:PTGS2
uniprot id: G3RPV2
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:CENPJ
gene id: 9595:CENPJ
uniprot id: G3RF23
names: Similarity
messages: Belongs to the TCP10 family.

9595:ENDOG
gene id: 9595:ENDOG
uniprot id: G3RE94
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9595:COPG1
gene id: 9595:COPG1
uniprot id: G3RE83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9595:CLDN14
gene id: 9595:CLDN14
uniprot id: G3RFZ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9595:PRKCZ
gene id: 9595:PRKCZ
uniprot id: A0A2I2Y2A6
uniprot id: A0A2I2YHG7
uniprot id: G3RB70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9595:SLC39A13
gene id: 9595:SLC39A13
uniprot id: G3S3Y4
names: Subcellular Location Annotation
messages: Membrane

9595:TM4SF20
gene id: 9595:TM4SF20
uniprot id: G3QDH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9595:PRPF4B
gene id: 9595:PRPF4B
uniprot id: G3QU86
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

9595:TRAM2
gene id: 9595:TRAM2
uniprot id: G3R8C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9595:CTSH
gene id: 9595:CTSH
uniprot id: G3R9A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9595:ZNF711
gene id: 9595:ZNF711
uniprot id: A0A2I2Z2R9
uniprot id: G3SIY6
names: Subcellular Location Annotation
messages: Nucleus

9595:MYH13
gene id: 9595:MYH13
uniprot id: G3RCQ6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:ACTN3
gene id: 9595:ACTN3
uniprot id: G3RIU2
names: Similarity
messages: Belongs to the alpha-actinin family.

9595:BMPR2
gene id: 9595:BMPR2
uniprot id: A0A2I2YY32
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9595:IL18RAP
gene id: 9595:IL18RAP
uniprot id: G3QSS6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9595:DDX18
gene id: 9595:DDX18
uniprot id: G3SEJ0
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9595:GRIN3A
gene id: 9595:GRIN3A
uniprot id: G3R217
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9595:REEP4
gene id: 9595:REEP4
uniprot id: A0A2I2ZFL5
uniprot id: A0A2I2ZJP1
uniprot id: G3QPB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:MVD
gene id: 9595:MVD
uniprot id: G3R9Z3
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

9595:SEC23B
gene id: 9595:SEC23B
uniprot id: G3SI15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9595:RRAGD
gene id: 9595:RRAGD
uniprot id: G3RSW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9595:SASS6
gene id: 9595:SASS6
uniprot id: G3QF34
names: Subcellular Location Annotation
messages: centrosome

9595:SATB1
gene id: 9595:SATB1
uniprot id: G3QHC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9595:DHODH
gene id: 9595:DHODH
uniprot id: G3RB74
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9595:HMGB1
gene id: 9595:HMGB1
uniprot id: G3SGE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9595:SSBP4
gene id: 9595:SSBP4
uniprot id: A0A2I2Z4A3
uniprot id: G3RL86
names: Subcellular Location Annotation
messages: Nucleus

9595:CERS2
gene id: 9595:CERS2
uniprot id: G3R775
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9595:CCNB2
gene id: 9595:CCNB2
uniprot id: G3QXD8
names: Similarity
messages: Belongs to the cyclin family.

9595:CCDC22
gene id: 9595:CCDC22
uniprot id: G3QF36
names: Similarity
messages: Belongs to the CCDC22 family.

9595:GPR61
gene id: 9595:GPR61
uniprot id: G3RDT0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:PSME3
gene id: 9595:PSME3
uniprot id: A0A2I2Z4R3
uniprot id: G3R573
names: Similarity
messages: Belongs to the PA28 family.

9595:SRPX
gene id: 9595:SRPX
uniprot id: G3RY54
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:TMEM53
gene id: 9595:TMEM53
uniprot id: G3QE44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9595:LOC101132832
gene id: 9595:LOC101132832
uniprot id: A0A2I2YCH5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9595:CYGB
gene id: 9595:CYGB
uniprot id: A0A2I2YA07
names: Similarity
messages: Belongs to the globin family.

9595:GALNT17
gene id: 9595:GALNT17
uniprot id: G3QSQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9595:TOM1L1
gene id: 9595:TOM1L1
uniprot id: G3RLQ6
names: Similarity
messages: Belongs to the TOM1 family.

9595:LSR
gene id: 9595:LSR
uniprot id: A0A2I2ZDH9
uniprot id: G3RQZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9595:GPR142
gene id: 9595:GPR142
uniprot id: G3RLJ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:TMC6
gene id: 9595:TMC6
uniprot id: G3QVR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9595:TIMP1
gene id: 9595:TIMP1
uniprot id: A0A2I2Z732
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9595:LOC101146886
gene id: 9595:LOC101146886
uniprot id: G3R050
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9595:ITK
gene id: 9595:ITK
uniprot id: G3QM29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9595:GRIA4
gene id: 9595:GRIA4
uniprot id: G3RLF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9595:FAP
gene id: 9595:FAP
uniprot id: G3RGI5
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9595:IFNGR1
gene id: 9595:IFNGR1
uniprot id: G3QZK7
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9595:EME1
gene id: 9595:EME1
uniprot id: G3R6Q2
names: Similarity
messages: Belongs to the EME1/MMS4 family.

9595:RASGRP2
gene id: 9595:RASGRP2
uniprot id: A0A2I2YWI9
uniprot id: G3RAC5
names: Similarity
messages: Belongs to the RASGRP family.

9595:MASP1
gene id: 9595:MASP1
uniprot id: A0A2I2Z7G1
uniprot id: G3QFW8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ANP32E
gene id: 9595:ANP32E
uniprot id: A0A2I2Y1Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9595:PKIG
gene id: 9595:PKIG
uniprot id: G3RN23
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9595:MRI1
gene id: 9595:MRI1
uniprot id: A0A2I2YEQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

9595:HOXC4
gene id: 9595:HOXC4
uniprot id: A0A2I2Z6R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9595:FGF18
gene id: 9595:FGF18
uniprot id: G3QWB5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:UST
gene id: 9595:UST
uniprot id: A0A2I2Z3G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:MARS1
gene id: 9595:MARS1
uniprot id: G3QHW7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9595:AGTR2
gene id: 9595:AGTR2
uniprot id: A0A2I2ZVH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

9595:TMEM208
gene id: 9595:TMEM208
uniprot id: G3QGK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9595:DUSP7
gene id: 9595:DUSP7
uniprot id: A0A2I2Y1Z9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9595:CASKIN2
gene id: 9595:CASKIN2
uniprot id: G3R1W4
names: Subcellular Location Annotation
messages: Cytoplasm

9595:PCYOX1L
gene id: 9595:PCYOX1L
uniprot id: G3QRN8
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9595:MTIF2
gene id: 9595:MTIF2
uniprot id: G3QXH7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9595:CSRNP2
gene id: 9595:CSRNP2
uniprot id: G3R4G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9595:TEX13B
gene id: 9595:TEX13B
uniprot id: G3S1W7
names: Similarity
messages: Belongs to the TEX13 family.

9595:HADHB
gene id: 9595:HADHB
uniprot id: G3S6V7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9595:LOC101131259
gene id: 9595:LOC101131259
uniprot id: G3S6W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9595:RPL8
gene id: 9595:RPL8
uniprot id: G3QYP0
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9595:TNFRSF8
gene id: 9595:TNFRSF8
uniprot id: G3QXP0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LAMB3
gene id: 9595:LAMB3
uniprot id: G3QZE3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:RBP1
gene id: 9595:RBP1
uniprot id: G3R9C4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9595:ADAMTS3
gene id: 9595:ADAMTS3
uniprot id: G3QLZ8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:SLC25A13
gene id: 9595:SLC25A13
uniprot id: G3QSP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:F2RL2
gene id: 9595:F2RL2
uniprot id: G3R7Z6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:MYO5B
gene id: 9595:MYO5B
uniprot id: G3QZT8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:PARD3B
gene id: 9595:PARD3B
uniprot id: A0A2I2YRT4
uniprot id: G3SKU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

9595:YTHDF1
gene id: 9595:YTHDF1
uniprot id: G3S5K9
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9595:TCN1
gene id: 9595:TCN1
uniprot id: G3SJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9595:ACOD1
gene id: 9595:ACOD1
uniprot id: G3RFY3
names: Similarity
messages: Belongs to the PrpD family.

9595:ADAMTS15
gene id: 9595:ADAMTS15
uniprot id: G3QX19
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:PSMC6
gene id: 9595:PSMC6
uniprot id: G3QIB5
names: Similarity
messages: Belongs to the AAA ATPase family.

9595:STEAP2
gene id: 9595:STEAP2
uniprot id: A0A2I2ZM14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9595:PTPN3
gene id: 9595:PTPN3
uniprot id: G3RTL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9595:WDR35
gene id: 9595:WDR35
uniprot id: A0A2I2ZRC1
uniprot id: G3R2V1
names: Function
names: Subcellular Location Annotation
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: centrosome
messages: cilium basal body

9595:THRAP3
gene id: 9595:THRAP3
uniprot id: G3QVJ9
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9595:PIWIL4
gene id: 9595:PIWIL4
uniprot id: G3RJJ5
names: Similarity
messages: Belongs to the argonaute family.

9595:POU3F4
gene id: 9595:POU3F4
uniprot id: A0A2I2YJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9595:ITPRIP
gene id: 9595:ITPRIP
uniprot id: A0A2I2ZK90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9595:SLC15A1
gene id: 9595:SLC15A1
uniprot id: G3RG12
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9595:RPL35
gene id: 9595:RPL35
uniprot id: G3QNC1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9595:HOXC6
gene id: 9595:HOXC6
uniprot id: G3QGY7
names: Subcellular Location Annotation
messages: Nucleus

9595:KMT5B
gene id: 9595:KMT5B
uniprot id: A0A2I2ZP50
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9595:YWHAG
gene id: 9595:YWHAG
uniprot id: G3S848
names: Similarity
messages: Belongs to the 14-3-3 family.

9595:MSH2
gene id: 9595:MSH2
uniprot id: G3QW00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

9595:RBM3
gene id: 9595:RBM3
uniprot id: G3QST9
names: Subcellular Location Annotation
messages: Cytoplasm

9595:NINJ2
gene id: 9595:NINJ2
uniprot id: G3QJT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9595:EDNRA
gene id: 9595:EDNRA
uniprot id: G3QEB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9595:CPLX3
gene id: 9595:CPLX3
uniprot id: G3QJP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9595:MAP2K6
gene id: 9595:MAP2K6
uniprot id: A0A2I2ZIV3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:PTPRZ1
gene id: 9595:PTPRZ1
uniprot id: G3SHA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9595:LOC101138927
gene id: 9595:LOC101138927
uniprot id: G3QN89
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9595:WDFY2
gene id: 9595:WDFY2
uniprot id: G3S422
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9595:CHGB
gene id: 9595:CHGB
uniprot id: G3QZT1
uniprot id: G3RZN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9595:SNX19
gene id: 9595:SNX19
uniprot id: G3SCC6
names: Similarity
messages: Belongs to the sorting nexin family.

9595:PTX3
gene id: 9595:PTX3
uniprot id: G3RH48
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:RPAP2
gene id: 9595:RPAP2
uniprot id: G3QUX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

9595:SPTSSB
gene id: 9595:SPTSSB
uniprot id: G3S643
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:WDR46
gene id: 9595:WDR46
uniprot id: G3QUN1
names: Subcellular Location Annotation
messages: nucleolus

9595:IYD
gene id: 9595:IYD
uniprot id: A0A2I2YAN4
uniprot id: A0A2I2ZDI2
names: Subcellular Location Annotation
messages: Cell membrane

9595:CCT6B
gene id: 9595:CCT6B
uniprot id: A0A2I2ZPT1
uniprot id: G3SDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9595:CCNY
gene id: 9595:CCNY
uniprot id: A0A2I2YSM3
uniprot id: G3RZR8
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9595:B9D2
gene id: 9595:B9D2
uniprot id: G3RKC6
names: Subcellular Location Annotation
messages: cilium basal body

9595:DIP2A
gene id: 9595:DIP2A
uniprot id: A0A2I2YJC3
names: Similarity
messages: Belongs to the DIP2 family.

9595:CEMIP2
gene id: 9595:CEMIP2
uniprot id: A0A2I2YYM0
uniprot id: G3R3Z3
names: Similarity
messages: Belongs to the CEMIP family.

9595:CLIC1
gene id: 9595:CLIC1
uniprot id: G3R6T1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9595:STS
gene id: 9595:STS
uniprot id: A0A2I2Z9J5
names: Similarity
messages: Belongs to the sulfatase family.

9595:WASL
gene id: 9595:WASL
uniprot id: G3S3Y1
names: Subcellular Location Annotation
messages: Nucleus

9595:LOC101129658
gene id: 9595:LOC101129658
uniprot id: G3QY92
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9595:NME5
gene id: 9595:NME5
uniprot id: G3QVZ0
names: Similarity
messages: Belongs to the NDK family.

9595:SERPINE2
gene id: 9595:SERPINE2
uniprot id: A0A2I2YS26
uniprot id: G3QF94
names: Similarity
messages: Belongs to the serpin family.

9595:PLXNB1
gene id: 9595:PLXNB1
uniprot id: G3QTS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:ECRG4
gene id: 9595:ECRG4
uniprot id: G3R5Z7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9595:TSPAN8
gene id: 9595:TSPAN8
uniprot id: G3RKT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9595:DDX3X
gene id: 9595:DDX3X
uniprot id: A0A2I2ZYD9
names: Similarity
messages: Belongs to the DEAD box helicase family.

9595:LOC101152850
gene id: 9595:LOC101152850
uniprot id: G3S8W7
names: Similarity
messages: Belongs to the PRR23 family.

9595:TRIM3
gene id: 9595:TRIM3
uniprot id: G3RBV0
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9595:ABCB4
gene id: 9595:ABCB4
uniprot id: A0A2I2ZJ25
names: Subcellular Location Annotation
messages: Membrane

9595:CD38
gene id: 9595:CD38
uniprot id: G3QTK1
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9595:FBXO48
gene id: 9595:FBXO48
uniprot id: G3QWM8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9595:SULT1C4
gene id: 9595:SULT1C4
uniprot id: A0A2I2Z451
uniprot id: G3QXV1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9595:YEATS4
gene id: 9595:YEATS4
uniprot id: G3RYG4
uniprot id: G3S5K4
names: Subcellular Location Annotation
messages: Nucleus

9595:ADHFE1
gene id: 9595:ADHFE1
uniprot id: G3QD50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9595:SYBU
gene id: 9595:SYBU
uniprot id: G3QM59
names: Subcellular Location Annotation
messages: Membrane

9595:GPR3
gene id: 9595:GPR3
uniprot id: A0A2I2Z3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LY75
gene id: 9595:LY75
uniprot id: G3RVS2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:LPAR6
gene id: 9595:LPAR6
uniprot id: G3RRG1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:PPCS
gene id: 9595:PPCS
uniprot id: G3S9J8
names: Similarity
messages: Belongs to the PPC synthetase family.

9595:UGT3A2
gene id: 9595:UGT3A2
uniprot id: G3QKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9595:PPP1R16B
gene id: 9595:PPP1R16B
uniprot id: G3RI06
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9595:LOC101127763
gene id: 9595:LOC101127763
uniprot id: A4H206
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antimicrobial activity.
messages: Secreted

9595:ANKS1B
gene id: 9595:ANKS1B
uniprot id: G3QZC4
names: Subcellular Location Annotation
messages: Cytoplasm

9595:HYCC1
gene id: 9595:HYCC1
uniprot id: A0A2I2YPE8
uniprot id: A0A2I2YR80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9595:ODAD4
gene id: 9595:ODAD4
uniprot id: G3QLZ5
names: Subcellular Location Annotation
messages: cilium axoneme

9595:BARHL1
gene id: 9595:BARHL1
uniprot id: G3QZ20
names: Subcellular Location Annotation
messages: Nucleus

9595:CASQ2
gene id: 9595:CASQ2
uniprot id: G3RLH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9595:COL4A2
gene id: 9595:COL4A2
uniprot id: G3RA26
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9595:SLC12A8
gene id: 9595:SLC12A8
uniprot id: G3QRX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9595:AK4
gene id: 9595:AK4
uniprot id: G3SGF3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9595:RGS3
gene id: 9595:RGS3
uniprot id: G3S4X9
names: Subcellular Location Annotation
messages: Cytoplasm

9595:MRPS16
gene id: 9595:MRPS16
uniprot id: G3RGE8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9595:ABCA12
gene id: 9595:ABCA12
uniprot id: G3RZY4
names: Subcellular Location Annotation
messages: Membrane

9595:TNFAIP6
gene id: 9595:TNFAIP6
uniprot id: G3S056
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:LOC101143535
gene id: 9595:LOC101143535
uniprot id: G3QIP9
names: Subcellular Location Annotation
messages: Membrane

9595:CD55
gene id: 9595:CD55
uniprot id: G3RY41
uniprot id: G3S1S0
uniprot id: G3SJV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:ATP5F1C
gene id: 9595:ATP5F1C
uniprot id: A0A2I2ZNG8
uniprot id: G3R2N5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9595:MRPS10
gene id: 9595:MRPS10
uniprot id: G3RAL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9595:IPO8
gene id: 9595:IPO8
uniprot id: G3S9A6
names: Subcellular Location Annotation
messages: Cytoplasm

9595:UBIAD1
gene id: 9595:UBIAD1
uniprot id: G3QG04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9595:SLC25A27
gene id: 9595:SLC25A27
uniprot id: A0A2I2YFM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:UGP2
gene id: 9595:UGP2
uniprot id: A0A2I2ZBI4
uniprot id: G3QTW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9595:YY1
gene id: 9595:YY1
uniprot id: G3S7S5
names: Similarity
messages: Belongs to the YY transcription factor family.

9595:MYO3A
gene id: 9595:MYO3A
uniprot id: G3QW52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

9595:UBALD1
gene id: 9595:UBALD1
uniprot id: A0A2I2YYH8
names: Similarity
messages: Belongs to the UBALD family.

9595:RFC2
gene id: 9595:RFC2
uniprot id: A0A2I2Z6Y7
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9595:CFAP97D1
gene id: 9595:CFAP97D1
uniprot id: G3RN08
names: Similarity
messages: Belongs to the CFAP97 family.

9595:SLC5A11
gene id: 9595:SLC5A11
uniprot id: A0A2I2YWT2
uniprot id: G3QH08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9595:COPS7A
gene id: 9595:COPS7A
uniprot id: G3R1B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9595:PPP2CA
gene id: 9595:PPP2CA
uniprot id: G3QDL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9595:PTH2R
gene id: 9595:PTH2R
uniprot id: G3RLB1
names: Subcellular Location Annotation
messages: Membrane

9595:KIF18A
gene id: 9595:KIF18A
uniprot id: G3QE28
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9595:FSHB
gene id: 9595:FSHB
uniprot id: A0A2K5TIY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9595:CLCN5
gene id: 9595:CLCN5
uniprot id: A0A2I2Z3B1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:VMA21
gene id: 9595:VMA21
uniprot id: A0A2I2YBK4
uniprot id: G3RHI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9595:LPXN
gene id: 9595:LPXN
uniprot id: G3QHQ4
uniprot id: G3S2X2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).
messages: focal adhesion
messages: perinuclear region
messages: podosome

9595:AFF4
gene id: 9595:AFF4
uniprot id: G3R7Z9
names: Similarity
messages: Belongs to the AF4 family.

9595:HCAR1
gene id: 9595:HCAR1
uniprot id: A0A2I2YNR0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:IL18
gene id: 9595:IL18
uniprot id: G3RIH2
uniprot id: G3SF34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted

9595:MUL1
gene id: 9595:MUL1
uniprot id: G3QUY4
names: Subcellular Location Annotation
messages: Membrane

9595:GPR119
gene id: 9595:GPR119
uniprot id: G3S749
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:SCGB2A1
gene id: 9595:SCGB2A1
uniprot id: G3SF48
names: Subcellular Location Annotation
messages: Secreted

9595:VAMP3
gene id: 9595:VAMP3
uniprot id: G3S2Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9595:TBX6
gene id: 9595:TBX6
uniprot id: A0A2K5TIZ6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9595:NDUFS4
gene id: 9595:NDUFS4
uniprot id: Q0MQH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. Interacts with BCAP31 and TOMM40; the interaction mediates its translocation to the mitochondria; the interaction with BCAP31 is direct.
messages: Mitochondrion inner membrane

9595:HSD17B4
gene id: 9595:HSD17B4
uniprot id: A0A2I2YBZ7
uniprot id: G3QHZ6
names: Subcellular Location Annotation
messages: Peroxisome

9595:RBL2
gene id: 9595:RBL2
uniprot id: G3RZ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9595:PPP1R9B
gene id: 9595:PPP1R9B
uniprot id: A0A2I2YAH8
names: Subcellular Location Annotation
messages: cytoskeleton

9595:SNTG1
gene id: 9595:SNTG1
uniprot id: A0A2I2YEY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9595:LAMTOR1
gene id: 9595:LAMTOR1
uniprot id: A0A2I2YP21
uniprot id: G3R9U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9595:C1QBP
gene id: 9595:C1QBP
uniprot id: G3QJU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

9595:LOC101143363
gene id: 9595:LOC101143363
uniprot id: G3SKW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:NGDN
gene id: 9595:NGDN
uniprot id: G3QQM9
names: Subcellular Location Annotation
messages: nucleolus

9595:ATP2B2
gene id: 9595:ATP2B2
uniprot id: G3R3U8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:NMB
gene id: 9595:NMB
uniprot id: G3S1K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9595:ALKAL2
gene id: 9595:ALKAL2
uniprot id: G3REI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9595:NPPB
gene id: 9595:NPPB
uniprot id: G3RR78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9595:KCNB1
gene id: 9595:KCNB1
uniprot id: G3QVG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: dendrite
messages: sarcolemma
messages: synaptosome

9595:LOC101124358
gene id: 9595:LOC101124358
uniprot id: G3SI34
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9595:C6H6orf89
gene id: 9595:C6H6orf89
uniprot id: A0A2I2YV80
uniprot id: G3RDJ4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9595:MSX1
gene id: 9595:MSX1
uniprot id: G3R151
names: Subcellular Location Annotation
messages: Nucleus

9595:GSTO2
gene id: 9595:GSTO2
uniprot id: G3QED5
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9595:SNX21
gene id: 9595:SNX21
uniprot id: A0A2I2YZQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Membrane

9595:CCR1
gene id: 9595:CCR1
uniprot id: A0A2I2ZT55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9595:SH2D1A
gene id: 9595:SH2D1A
uniprot id: G3SKS3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9595:AKAP9
gene id: 9595:AKAP9
uniprot id: G3QWV6
names: Subcellular Location Annotation
messages: centrosome

9595:CERS6
gene id: 9595:CERS6
uniprot id: A0A2I2YTR2
uniprot id: A0A2I2ZNM1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9595:DDAH1
gene id: 9595:DDAH1
uniprot id: A0A2I2Z7B9
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9595:MALSU1
gene id: 9595:MALSU1
uniprot id: G3R441
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9595:SYNGR4
gene id: 9595:SYNGR4
uniprot id: G3SAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9595:CD74
gene id: 9595:CD74
uniprot id: G3R7S6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:S100A11
gene id: 9595:S100A11
uniprot id: G3R007
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

9595:ZNRF4
gene id: 9595:ZNRF4
uniprot id: G3QJR4
names: Subcellular Location Annotation
messages: Membrane

9595:CCDC172
gene id: 9595:CCDC172
uniprot id: G3QNB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

9595:SPSB3
gene id: 9595:SPSB3
uniprot id: G3QTS9
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9595:DAXX
gene id: 9595:DAXX
uniprot id: G3SCB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

9595:PTCH1
gene id: 9595:PTCH1
uniprot id: A0A2I2ZGX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9595:SCML1
gene id: 9595:SCML1
uniprot id: G3QMQ6
names: Similarity
messages: Belongs to the SCM family.

9595:SCUBE2
gene id: 9595:SCUBE2
uniprot id: A0A2I2Z6E5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:NAT9
gene id: 9595:NAT9
uniprot id: A0A2I2Y9D7
uniprot id: G3QL83
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

9595:CLCN4
gene id: 9595:CLCN4
uniprot id: G3R5V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9595:ART3
gene id: 9595:ART3
uniprot id: A0A2I2YM94
uniprot id: G3SFL6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9595:INSIG2
gene id: 9595:INSIG2
uniprot id: G3RIH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9595:CRYGA
gene id: 9595:CRYGA
uniprot id: G3RM47
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9595:RPS16
gene id: 9595:RPS16
uniprot id: G3S6Q1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9595:RABGGTA
gene id: 9595:RABGGTA
uniprot id: A0A2I2ZP66
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9595:F9
gene id: 9595:F9
uniprot id: G3QEB7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9595:RPS6KA2
gene id: 9595:RPS6KA2
uniprot id: A0A2I2YGP7
uniprot id: G3SHK7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9595:CACUL1
gene id: 9595:CACUL1
uniprot id: G3QGH4
names: Similarity
messages: Belongs to the cullin family.

9595:VTI1A
gene id: 9595:VTI1A
uniprot id: A0A2I2ZMC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9595:CNPY2
gene id: 9595:CNPY2
uniprot id: G3R152
names: Similarity
messages: Belongs to the canopy family.

9595:LOC109027173
gene id: 9595:LOC109027173
uniprot id: G3S0N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:LOC101127306
gene id: 9595:LOC101127306
uniprot id: G3SIN5
names: Similarity
messages: Belongs to the globin family.

9595:PLAU
gene id: 9595:PLAU
uniprot id: G3RGY4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:SLC35F6
gene id: 9595:SLC35F6
uniprot id: A0A2I2Z189
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9595:SLCO2B1
gene id: 9595:SLCO2B1
uniprot id: A0A2I2YC36
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:DSG2
gene id: 9595:DSG2
uniprot id: G3S5H2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9595:SERP1
gene id: 9595:SERP1
uniprot id: G3RR15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9595:PRKRIP1
gene id: 9595:PRKRIP1
uniprot id: G3QXK8
names: Similarity
messages: Belongs to the PRKRIP1 family.

9595:UBE2F
gene id: 9595:UBE2F
uniprot id: G3R574
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:KDM1B
gene id: 9595:KDM1B
uniprot id: G3QLA3
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9595:CCL13
gene id: 9595:CCL13
uniprot id: G3QK67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:SLC25A37
gene id: 9595:SLC25A37
uniprot id: A0A2I2ZXB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9595:ADH5
gene id: 9595:ADH5
uniprot id: G3RV06
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9595:CORO1A
gene id: 9595:CORO1A
uniprot id: G3RAD2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

9595:NKIRAS1
gene id: 9595:NKIRAS1
uniprot id: G3RC04
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9595:CHRND
gene id: 9595:CHRND
uniprot id: G3QI64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9595:C4BPB
gene id: 9595:C4BPB
uniprot id: A0A2I2YWR4
uniprot id: G3R971
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:VIPR1
gene id: 9595:VIPR1
uniprot id: A0A2I2Z2U4
uniprot id: G3QNP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9595:PSMB10
gene id: 9595:PSMB10
uniprot id: G3RDF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9595:RPL27
gene id: 9595:RPL27
uniprot id: G3S8W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9595:DOK2
gene id: 9595:DOK2
uniprot id: G3QD93
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9595:NECTIN4
gene id: 9595:NECTIN4
uniprot id: A0A2I2YMG4
names: Similarity
messages: Belongs to the nectin family.

9595:PER1
gene id: 9595:PER1
uniprot id: G3QSL0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9595:LOC101143888
gene id: 9595:LOC101143888
uniprot id: G3R150
names: Similarity
messages: Belongs to the cytochrome P450 family.

9595:GORASP2
gene id: 9595:GORASP2
uniprot id: G3R9Y6
names: Similarity
messages: Belongs to the GORASP family.

9595:SLC18A2
gene id: 9595:SLC18A2
uniprot id: A0A2I2ZPT5
names: Subcellular Location Annotation
messages: Membrane

9595:PSMD9
gene id: 9595:PSMD9
uniprot id: G3QVE5
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9595:CTSA
gene id: 9595:CTSA
uniprot id: G3RIP1
names: Similarity
messages: Belongs to the peptidase S10 family.

9595:TNFRSF9
gene id: 9595:TNFRSF9
uniprot id: G3RKZ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:PLPPR4
gene id: 9595:PLPPR4
uniprot id: G3RCC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9595:TINAGL1
gene id: 9595:TINAGL1
uniprot id: G3RS19
names: Similarity
messages: Belongs to the peptidase C1 family.

9595:GNG4
gene id: 9595:GNG4
uniprot id: G3QY03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9595:LOC101143276
gene id: 9595:LOC101143276
uniprot id: G3RL98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:XRCC5
gene id: 9595:XRCC5
uniprot id: G3R763
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

9595:STRADB
gene id: 9595:STRADB
uniprot id: G3R920
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9595:SNCB
gene id: 9595:SNCB
uniprot id: G3RIF1
names: Similarity
messages: Belongs to the synuclein family.

9595:PDCD10
gene id: 9595:PDCD10
uniprot id: G3SFY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9595:SWI5
gene id: 9595:SWI5
uniprot id: A0A2I2ZG41
names: Function
names: Similarity
messages: Belongs to the SWI5/SAE3 family.
messages: Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination.

9595:SCAMP3
gene id: 9595:SCAMP3
uniprot id: G3R1X9
uniprot id: G3SG04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9595:TMEM126B
gene id: 9595:TMEM126B
uniprot id: G3QI97
names: Subcellular Location Annotation
messages: Membrane

9595:CRBN
gene id: 9595:CRBN
uniprot id: A0A2I2YW55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9595:ANXA2
gene id: 9595:ANXA2
uniprot id: G3S932
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

9595:FGFR1
gene id: 9595:FGFR1
uniprot id: G3RBC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9595:ADPRH
gene id: 9595:ADPRH
uniprot id: G3QR17
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9595:OTC
gene id: 9595:OTC
uniprot id: G3R7S1
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9595:PMVK
gene id: 9595:PMVK
uniprot id: G3RAP6
names: Subcellular Location Annotation
messages: cytosol

9595:CALB2
gene id: 9595:CALB2
uniprot id: A0A2I2YTV9
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9595:GLB1
gene id: 9595:GLB1
uniprot id: A0A2I2ZE55
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9595:NDUFS1
gene id: 9595:NDUFS1
uniprot id: A0A2I2ZR47
uniprot id: Q0MQG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Complex I associates with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity). Interacts with MDM2 and AKAP1 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity).
messages: Mitochondrion inner membrane

9595:DESI2
gene id: 9595:DESI2
uniprot id: G3R2V6
names: Similarity
messages: Belongs to the DeSI family.

9595:RICTOR
gene id: 9595:RICTOR
uniprot id: A0A2I2ZHJ0
uniprot id: G3S715
names: Similarity
messages: Belongs to the RICTOR family.

9595:ATP1A1
gene id: 9595:ATP1A1
uniprot id: G3RZN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9595:KIT
gene id: 9595:KIT
uniprot id: G3RHF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9595:MGAT4D
gene id: 9595:MGAT4D
uniprot id: G3RSK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane

9595:HMGCS2
gene id: 9595:HMGCS2
uniprot id: G3R459
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9595:ATAT1
gene id: 9595:ATAT1
uniprot id: A0A2I2ZG01
uniprot id: A0A2I2ZXP3
uniprot id: G3R6S6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

9595:FADD
gene id: 9595:FADD
uniprot id: G3RWC4
names: Function
messages: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

9595:TFAP2B
gene id: 9595:TFAP2B
uniprot id: G3RF96
uniprot id: G3SBQ3
names: Similarity
messages: Belongs to the AP-2 family.

9595:LALBA
gene id: 9595:LALBA
uniprot id: G3SBC1
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9595:SMARCA5
gene id: 9595:SMARCA5
uniprot id: G3SF21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9595:USP37
gene id: 9595:USP37
uniprot id: A0A2I2ZV90
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:ZNF394
gene id: 9595:ZNF394
uniprot id: G3RCS9
names: Subcellular Location Annotation
messages: Nucleus

9595:NAXE
gene id: 9595:NAXE
uniprot id: G3RUT3
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
messages: Homodimer. Interacts with APOA1 and APOA2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

9595:LOC101133344
gene id: 9595:LOC101133344
uniprot id: G3RQE4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:TANGO6
gene id: 9595:TANGO6
uniprot id: G3R3G9
names: Similarity
messages: Belongs to the Tango6 family.

9595:DCTN6
gene id: 9595:DCTN6
uniprot id: A0A2I2YXG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: cytoskeleton

9595:RPL5
gene id: 9595:RPL5
uniprot id: G3QJR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9595:ATP8B4
gene id: 9595:ATP8B4
uniprot id: G3RQS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9595:DHX15
gene id: 9595:DHX15
uniprot id: G3RKY1
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9595:CBR1
gene id: 9595:CBR1
uniprot id: G3QKD3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9595:LOC101125955
gene id: 9595:LOC101125955
uniprot id: A0A2I2Z7R6
names: Similarity
messages: Belongs to the PRR23 family.

9595:MYO5C
gene id: 9595:MYO5C
uniprot id: G3RCG3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9595:PAQR3
gene id: 9595:PAQR3
uniprot id: A0A2I2YL44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9595:INTS7
gene id: 9595:INTS7
uniprot id: G3R8X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9595:CAPN13
gene id: 9595:CAPN13
uniprot id: G3RHW3
names: Similarity
messages: Belongs to the peptidase C2 family.

9595:SLC26A1
gene id: 9595:SLC26A1
uniprot id: A0A2I2YTK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate.

9595:GAREM1
gene id: 9595:GAREM1
uniprot id: A0A2I2YBT0
names: Similarity
messages: Belongs to the GAREM family.

9595:UBE2G1
gene id: 9595:UBE2G1
uniprot id: A0A2I2ZY55
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9595:HOXB7
gene id: 9595:HOXB7
uniprot id: A1YFA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Antp homeobox family.
messages: Forms a DNA-binding heterodimer with transcription factor PBX1.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9595:BBS5
gene id: 9595:BBS5
uniprot id: A0A2I2ZW94
uniprot id: G3QRG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9595:LOC101136189
gene id: 9595:LOC101136189
uniprot id: A0A2I2YVA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MAS1
gene id: 9595:MAS1
uniprot id: G3R4L5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:DGKG
gene id: 9595:DGKG
uniprot id: A0A2I2ZD87
uniprot id: A0A2I2ZRN0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9595:NR5A2
gene id: 9595:NR5A2
uniprot id: G3R3Z2
uniprot id: G3S1U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9595:AFMID
gene id: 9595:AFMID
uniprot id: G3QVU4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: cytosol

9595:GRM4
gene id: 9595:GRM4
uniprot id: G3QRF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9595:RPS18
gene id: 9595:RPS18
uniprot id: G3QUM7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.

9595:SCAMP2
gene id: 9595:SCAMP2
uniprot id: A0A2I2YV30
uniprot id: A0A2I2ZS17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9595:MINAR1
gene id: 9595:MINAR1
uniprot id: G3R9M4
names: Similarity
messages: Belongs to the MINAR family.

9595:LOC101131103
gene id: 9595:LOC101131103
uniprot id: A0A2I2ZDJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:SH2B3
gene id: 9595:SH2B3
uniprot id: A0A2I2Z002
names: Similarity
messages: Belongs to the SH2B adapter family.

9595:MED9
gene id: 9595:MED9
uniprot id: G3R6K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9595:ZHX3
gene id: 9595:ZHX3
uniprot id: G3R023
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9595:RFTN2
gene id: 9595:RFTN2
uniprot id: G3R1M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9595:USP30
gene id: 9595:USP30
uniprot id: G3R2E3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9595:DERL1
gene id: 9595:DERL1
uniprot id: G3R0M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9595:GHITM
gene id: 9595:GHITM
uniprot id: G3R5Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9595:MAK16
gene id: 9595:MAK16
uniprot id: G3R4M4
names: Similarity
messages: Belongs to the MAK16 family.

9595:BGN
gene id: 9595:BGN
uniprot id: G3QWA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

9595:TGFB3
gene id: 9595:TGFB3
uniprot id: G3QGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9595:SLC25A23
gene id: 9595:SLC25A23
uniprot id: G3S9R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9595:BTF3
gene id: 9595:BTF3
uniprot id: G3QD56
names: Similarity
messages: Belongs to the NAC-beta family.

9595:KXD1
gene id: 9595:KXD1
uniprot id: A0A2I2Y232
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9595:SPNS2
gene id: 9595:SPNS2
uniprot id: G3RX14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9595:SCRN3
gene id: 9595:SCRN3
uniprot id: G3SKU3
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9595:EPHA3
gene id: 9595:EPHA3
uniprot id: G3RG43
names: Subcellular Location Annotation
messages: Membrane

9595:RCAN2
gene id: 9595:RCAN2
uniprot id: G3QPS7
uniprot id: G3S776
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9595:POSTN
gene id: 9595:POSTN
uniprot id: A0A2I2YTD4
uniprot id: A0A2I2YVT8
uniprot id: A0A2I2ZP34
uniprot id: G3QUZ5
names: Subcellular Location Annotation
messages: extracellular matrix

9595:GMPPA
gene id: 9595:GMPPA
uniprot id: G3SHF2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9595:BRPF1
gene id: 9595:BRPF1
uniprot id: A0A2I2ZS35
uniprot id: G3REC3
names: Subcellular Location Annotation
messages: Nucleus

9595:EXOC4
gene id: 9595:EXOC4
uniprot id: G3QMY0
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9595:CDC26
gene id: 9595:CDC26
uniprot id: G3R308
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9595:NDUFA8
gene id: 9595:NDUFA8
uniprot id: Q0MQB0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9595:POLR2C
gene id: 9595:POLR2C
uniprot id: G3RTN0
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9595:FGF9
gene id: 9595:FGF9
uniprot id: G3QQL4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9595:C2AH2orf49
gene id: 9595:C2AH2orf49
uniprot id: G3S591
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9595:POLR3C
gene id: 9595:POLR3C
uniprot id: G3QWH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9595:LOC101123691
gene id: 9595:LOC101123691
uniprot id: G3R4Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:MFSD9
gene id: 9595:MFSD9
uniprot id: A0A2I2ZMH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9595:CXCL6
gene id: 9595:CXCL6
uniprot id: G3R3B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:MRPS11
gene id: 9595:MRPS11
uniprot id: G3RGN4
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9595:LOC101138067
gene id: 9595:LOC101138067
uniprot id: G3RFI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9595:LDLRAD4
gene id: 9595:LDLRAD4
uniprot id: A0A2I2YGK7
uniprot id: A0A2I2YS19
uniprot id: G3RCG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:GAB3
gene id: 9595:GAB3
uniprot id: G3QFF6
names: Similarity
messages: Belongs to the GAB family.

9595:CILP
gene id: 9595:CILP
uniprot id: A0A2I2YZ36
names: Subcellular Location Annotation
messages: extracellular matrix

9595:ANO10
gene id: 9595:ANO10
uniprot id: G3RE27
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:HR
gene id: 9595:HR
uniprot id: G3QPB1
uniprot id: G3RZX8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9595:DLGAP1
gene id: 9595:DLGAP1
uniprot id: A0A2I2YGA1
uniprot id: A0A2I2YVL4
uniprot id: A0A2I2ZKN2
uniprot id: G3SKG4
names: Similarity
messages: Belongs to the SAPAP family.

9595:TBL3
gene id: 9595:TBL3
uniprot id: G3R1T7
names: Subcellular Location Annotation
messages: nucleolus

9595:ARSK
gene id: 9595:ARSK
uniprot id: G3QSM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome

9595:MLF1
gene id: 9595:MLF1
uniprot id: G3S8S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9595:SHROOM4
gene id: 9595:SHROOM4
uniprot id: A0A2I2YGZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9595:PTCD3
gene id: 9595:PTCD3
uniprot id: G3QHE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9595:TCP10L
gene id: 9595:TCP10L
uniprot id: A0A2I2Y236
names: Similarity
messages: Belongs to the TCP10 family.

9595:SLC6A2
gene id: 9595:SLC6A2
uniprot id: G3QR21
uniprot id: G3RMU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9595:LTBP2
gene id: 9595:LTBP2
uniprot id: G3SCK9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9595:ATL3
gene id: 9595:ATL3
uniprot id: A0A2I2ZNA4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9595:PAX9
gene id: 9595:PAX9
uniprot id: G3QGP5
names: Subcellular Location Annotation
messages: Nucleus

9595:GPR155
gene id: 9595:GPR155
uniprot id: G3SBT6
names: Subcellular Location Annotation
messages: Membrane

9595:SNX30
gene id: 9595:SNX30
uniprot id: G3QNL2
names: Similarity
messages: Belongs to the sorting nexin family.

9595:KCND2
gene id: 9595:KCND2
uniprot id: A0A2I2YDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9595:SCG5
gene id: 9595:SCG5
uniprot id: G3RJS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9595:LDB2
gene id: 9595:LDB2
uniprot id: A0A2I2ZYG9
names: Similarity
messages: Belongs to the LDB family.

9595:TRIM54
gene id: 9595:TRIM54
uniprot id: A0A2I2Z362
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9595:SESN1
gene id: 9595:SESN1
uniprot id: A0A2I2YZC4
uniprot id: G3QYS2
uniprot id: G3RU39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9595:PTGES
gene id: 9595:PTGES
uniprot id: A0A2I2YMC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9595:DCP1B
gene id: 9595:DCP1B
uniprot id: G3S7W5
names: Similarity
messages: Belongs to the DCP1 family.

9595:APAF1
gene id: 9595:APAF1
uniprot id: A0A2I2YKE3
uniprot id: A0A2I2ZPS0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

9595:CALY
gene id: 9595:CALY
uniprot id: G3QT06
names: Similarity
messages: Belongs to the NSG family.

9595:LOC101127832
gene id: 9595:LOC101127832
uniprot id: G3R1D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:PPA1
gene id: 9595:PPA1
uniprot id: G3RLE5
names: Similarity
messages: Belongs to the PPase family.

9595:ZSCAN21
gene id: 9595:ZSCAN21
uniprot id: G3R736
names: Subcellular Location Annotation
messages: Nucleus

9595:VAMP8
gene id: 9595:VAMP8
uniprot id: G3QQI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9595:RXRB
gene id: 9595:RXRB
uniprot id: G3R2Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9595:POLR2F
gene id: 9595:POLR2F
uniprot id: A0A2I2ZC79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9595:RNF170
gene id: 9595:RNF170
uniprot id: G3QQE5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9595:NSDHL
gene id: 9595:NSDHL
uniprot id: G3RLK2
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9595:SF3A1
gene id: 9595:SF3A1
uniprot id: G3RA68
names: Subcellular Location Annotation
messages: Nucleus

9595:RAP1GDS1
gene id: 9595:RAP1GDS1
uniprot id: A0A2I2YZK7
uniprot id: G3QPH3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion

9595:CCNG2
gene id: 9595:CCNG2
uniprot id: G3RRB1
names: Similarity
messages: Belongs to the cyclin family.

9595:LRRC8C
gene id: 9595:LRRC8C
uniprot id: G3SFV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9595:RNASEH2B
gene id: 9595:RNASEH2B
uniprot id: A0A2I2YP62
uniprot id: G3QFF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

9595:LOC101129673
gene id: 9595:LOC101129673
uniprot id: A0A2I2ZTX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9595:ADAMTS2
gene id: 9595:ADAMTS2
uniprot id: A0A2I2YQ87
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9595:OS9
gene id: 9595:OS9
uniprot id: A0A2I2ZSU4
uniprot id: G3QGC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9595:ZNF215
gene id: 9595:ZNF215
uniprot id: G3QMM6
names: Subcellular Location Annotation
messages: Nucleus

9595:UTRN
gene id: 9595:UTRN
uniprot id: G3S2D7
names: Subcellular Location Annotation
messages: cytoskeleton

9595:TAAR1
gene id: 9595:TAAR1
uniprot id: G3RZ14
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9595:LYZL6
gene id: 9595:LYZL6
uniprot id: G3R4J6
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9595:GSX2
gene id: 9595:GSX2
uniprot id: G3QY28
names: Subcellular Location Annotation
messages: Nucleus

9595:SLC35B4
gene id: 9595:SLC35B4
uniprot id: G3QH86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9595:IDH3B
gene id: 9595:IDH3B
uniprot id: G3R3G3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9595:ZNF280C
gene id: 9595:ZNF280C
uniprot id: G3RMJ0
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9595:CTNNBL1
gene id: 9595:CTNNBL1
uniprot id: G3QEB4
names: Subcellular Location Annotation
messages: Nucleus

9595:ITGA3
gene id: 9595:ITGA3
uniprot id: G3RCK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9595:LOC101134092
gene id: 9595:LOC101134092
uniprot id: G3SET6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9595:STK38L
gene id: 9595:STK38L
uniprot id: G3QHG5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9595:FZD7
gene id: 9595:FZD7
uniprot id: A0A2I2ZTF8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9595:SGCE
gene id: 9595:SGCE
uniprot id: A0A2I2YDG7
uniprot id: A0A2I2Z2X0
uniprot id: G3QKY4
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

9595:EIF4A3
gene id: 9595:EIF4A3
uniprot id: G3RAX3
names: Similarity
messages: Belongs to the DEAD box helicase family.

9595:HIF1A
gene id: 9595:HIF1A
uniprot id: A0A2I2ZEQ0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle

9595:CDH11
gene id: 9595:CDH11
uniprot id: G3QKI4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9595:RSPO3
gene id: 9595:RSPO3
uniprot id: G3SBH2
names: Similarity
messages: Belongs to the R-spondin family.

9595:DDX5
gene id: 9595:DDX5
uniprot id: G3RHC7
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9595:MMP26
gene id: 9595:MMP26
uniprot id: G3R6L8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9595:SYT2
gene id: 9595:SYT2
uniprot id: G3QPB7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9595:ORC1
gene id: 9595:ORC1
uniprot id: G3QMW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus

9595:DYNLT1
gene id: 9595:DYNLT1
uniprot id: A0A2I2YU98
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9595:TTR
gene id: 9595:TTR
uniprot id: G3S3S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9595:TP53I11
gene id: 9595:TP53I11
uniprot id: A0A2I2YBP2
names: Subcellular Location Annotation
messages: Membrane

9595:RPL36A
gene id: 9595:RPL36A
uniprot id: G3R205
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9595:IER3IP1
gene id: 9595:IER3IP1
uniprot id: G3RM54
names: Similarity
messages: Belongs to the YOS1 family.

9595:HS2ST1
gene id: 9595:HS2ST1
uniprot id: A0A2I2YUR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9595:CCL28
gene id: 9595:CCL28
uniprot id: A0A2I2YCD7
uniprot id: G3RAN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9595:SYN1
gene id: 9595:SYN1
uniprot id: G3R034
names: Similarity
messages: Belongs to the synapsin family.

9595:CD14
gene id: 9595:CD14
uniprot id: G3R4C0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

9595:CALCB
gene id: 9595:CALCB
uniprot id: A0A2I2ZIT6
names: Similarity
messages: Belongs to the calcitonin family.

9595:PRPF19
gene id: 9595:PRPF19
uniprot id: G3QZY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9595:FNTB
gene id: 9595:FNTB
uniprot id: G3R1C3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.