9544:UBP1
gene id: 9544:UBP1
uniprot id: A0A8J8YS88
uniprot id: F7CJ26
uniprot id: F7GGQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9544:MRPL12
gene id: 9544:MRPL12
uniprot id: A0A8J8XFI2
uniprot id: G7NHA1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9544:EIF2B5
gene id: 9544:EIF2B5
uniprot id: A0A1D5RIQ2
uniprot id: A0A8J8Y653
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

9544:CIAO1
gene id: 9544:CIAO1
uniprot id: A0A8J8XKG5
uniprot id: F6SGP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9544:TMEM126B
gene id: 9544:TMEM126B
uniprot id: A0A8J8XM76
uniprot id: F6WC76
names: Subcellular Location Annotation
messages: Membrane

9544:FAM110C
gene id: 9544:FAM110C
uniprot id: A0A5F7ZBY0
names: Similarity
messages: Belongs to the FAM110 family.

9544:FAM210A
gene id: 9544:FAM210A
uniprot id: F7HI95
names: Similarity
messages: Belongs to the FAM210 family.

9544:LOC697115
gene id: 9544:LOC697115
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:NOX4
gene id: 9544:NOX4
uniprot id: A0A1D5RB90
uniprot id: F6WZN5
names: Subcellular Location Annotation
messages: Membrane

9544:GAP43
gene id: 9544:GAP43
uniprot id: F7FEE8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9544:MOB3C
gene id: 9544:MOB3C
uniprot id: A0A8J8Y3Y8
uniprot id: F6TJT6
names: Similarity
messages: Belongs to the MOB1/phocein family.

9544:NRXN1
gene id: 9544:NRXN1
uniprot id: H9EP08
uniprot id: H9G200
uniprot id: I2CYY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Presynaptic cell membrane

9544:CIRBP
gene id: 9544:CIRBP
uniprot id: I0FHP5
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

9544:PSMD12
gene id: 9544:PSMD12
uniprot id: F6UPI2
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9544:ADPRHL2
gene id: 9544:ADPRHL2
uniprot id: F7GY61
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9544:FBL
gene id: 9544:FBL
uniprot id: H9YV05
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

9544:DAG1
gene id: 9544:DAG1
uniprot id: F6RU72
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9544:PRLHR
gene id: 9544:PRLHR
uniprot id: A0A5F8AHK6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:PDIA2
gene id: 9544:PDIA2
uniprot id: I2CUR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9544:AMIGO1
gene id: 9544:AMIGO1
uniprot id: A0A8J8YJQ1
uniprot id: F6VL60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9544:CENPN
gene id: 9544:CENPN
uniprot id: A0A8J8XXG2
uniprot id: G7NR50
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9544:SEZ6L2
gene id: 9544:SEZ6L2
uniprot id: G7NQI5
uniprot id: H9FSV3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:GUCY2C
gene id: 9544:GUCY2C
uniprot id: A0A5F8ATF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9544:OSBPL5
gene id: 9544:OSBPL5
uniprot id: F7A4B4
names: Similarity
messages: Belongs to the OSBP family.

9544:GSS
gene id: 9544:GSS
uniprot id: F7EMC7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9544:SLC25A3
gene id: 9544:SLC25A3
uniprot id: A0A8J8Y412
uniprot id: F6VER2
uniprot id: I0FSL7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9544:KAT5
gene id: 9544:KAT5
uniprot id: F7FU99
uniprot id: G7NC89
uniprot id: I2CWB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9544:BEST3
gene id: 9544:BEST3
uniprot id: F6SEM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9544:ABCG4
gene id: 9544:ABCG4
uniprot id: A0A8J8XJH7
uniprot id: F6TDE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9544:RSBN1L
gene id: 9544:RSBN1L
uniprot id: H9FRB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9544:PDIA3
gene id: 9544:PDIA3
uniprot id: F6W4X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9544:FLAD1
gene id: 9544:FLAD1
uniprot id: G7MDV3
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9544:PRICKLE1
gene id: 9544:PRICKLE1
uniprot id: F7E2K2
uniprot id: F7HTJ1
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9544:HOOK2
gene id: 9544:HOOK2
uniprot id: F6U5D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9544:PTGES3
gene id: 9544:PTGES3
uniprot id: H9EM56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9544:CASC3
gene id: 9544:CASC3
uniprot id: A0A1D5R604
uniprot id: F6XDK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

9544:SCARB1
gene id: 9544:SCARB1
uniprot id: A0A5K1VMB9
uniprot id: F7G7I7
uniprot id: H9EW01
names: Similarity
messages: Belongs to the CD36 family.

9544:RPS26
gene id: 9544:RPS26
uniprot id: F7HQQ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9544:LDAH
gene id: 9544:LDAH
uniprot id: A0A1D5Q6Z1
uniprot id: F6ZP20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

9544:CRYBA1
gene id: 9544:CRYBA1
uniprot id: A0A8J8XG60
uniprot id: F6T4W0
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9544:ABCD2
gene id: 9544:ABCD2
uniprot id: G7N6P7
names: Subcellular Location Annotation
messages: Membrane

9544:GABPA
gene id: 9544:GABPA
uniprot id: A0A8J8Y3P3
uniprot id: H9Z7C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:NXT1
gene id: 9544:NXT1
uniprot id: A0A8J8YF69
uniprot id: F6YYV6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9544:AGTRAP
gene id: 9544:AGTRAP
uniprot id: A0A1D5REK8
uniprot id: A0A8J8YQF2
names: Subcellular Location Annotation
messages: Membrane

9544:TARS2
gene id: 9544:TARS2
uniprot id: F7H541
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9544:AOC2
gene id: 9544:AOC2
uniprot id: F7GP69
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9544:LOC700794
gene id: 9544:LOC700794
uniprot id: F6PUQ9
names: Similarity
messages: Belongs to the SPAN-X family.

9544:TGFBI
gene id: 9544:TGFBI
uniprot id: F6YTU1
names: Subcellular Location Annotation
messages: extracellular matrix

9544:SPTY2D1
gene id: 9544:SPTY2D1
uniprot id: H9FQ94
names: Similarity
messages: Belongs to the SPT2 family.

9544:CYP17A1
gene id: 9544:CYP17A1
uniprot id: Q5IFH9
uniprot id: Q8HYM9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity.

9544:SLC35E3
gene id: 9544:SLC35E3
uniprot id: H9EVJ5
names: Subcellular Location Annotation
messages: Membrane

9544:ME1
gene id: 9544:ME1
uniprot id: A0A8J8YS82
uniprot id: G7MPT7
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9544:TNFSF8
gene id: 9544:TNFSF8
uniprot id: A0A1D5RK03
uniprot id: A0A8J8Y7E9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9544:CHRM2
gene id: 9544:CHRM2
uniprot id: G7MML6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9544:B4GAT1
gene id: 9544:B4GAT1
uniprot id: G7NC61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:MMP26
gene id: 9544:MMP26
uniprot id: A0A8J8YDI3
uniprot id: F6QMZ1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9544:SRP68
gene id: 9544:SRP68
uniprot id: F7D5D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9544:GABRG1
gene id: 9544:GABRG1
uniprot id: A0A5K1TUL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:DRAM2
gene id: 9544:DRAM2
uniprot id: A0A5F7ZPJ9
uniprot id: A0A8J8YPI5
uniprot id: G7MIG5
names: Subcellular Location Annotation
messages: Membrane

9544:TSPYL2
gene id: 9544:TSPYL2
uniprot id: I2CU67
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:RFTN2
gene id: 9544:RFTN2
uniprot id: I2CY69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9544:SLC35A5
gene id: 9544:SLC35A5
uniprot id: F7D791
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:TCP1
gene id: 9544:TCP1
uniprot id: F6T521
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: centrosome

9544:RNF13
gene id: 9544:RNF13
uniprot id: A0A1D5Q7Q2
uniprot id: H9ELX5
names: Subcellular Location Annotation
messages: Membrane

9544:TMEM178A
gene id: 9544:TMEM178A
uniprot id: H9FPY6
names: Similarity
messages: Belongs to the TMEM178 family.

9544:ATL1
gene id: 9544:ATL1
uniprot id: A0A5K1TYG0
uniprot id: H9FV61
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9544:AASS
gene id: 9544:AASS
uniprot id: G7MM77
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9544:CLSTN3
gene id: 9544:CLSTN3
uniprot id: A0A1D5QYE4
uniprot id: A0A8J8YNY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

9544:GAPDHS
gene id: 9544:GAPDHS
uniprot id: F6Q1J4
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9544:FGF20
gene id: 9544:FGF20
uniprot id: A0A5F8AS31
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:PSMD2
gene id: 9544:PSMD2
uniprot id: F6R1X3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9544:LOC698582
gene id: 9544:LOC698582
uniprot id: H9G077
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:NOL10
gene id: 9544:NOL10
uniprot id: A0A5K1VU09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9544:MAN1A1
gene id: 9544:MAN1A1
uniprot id: F6YY29
uniprot id: I2CU20
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9544:G6PD
gene id: 9544:G6PD
uniprot id: H9ESV7
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

9544:SBDS
gene id: 9544:SBDS
uniprot id: A0A8J8YHG6
uniprot id: G7MP28
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9544:SLC25A13
gene id: 9544:SLC25A13
uniprot id: F7BR40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:CIAO2B
gene id: 9544:CIAO2B
uniprot id: F7GLS5
names: Similarity
messages: Belongs to the MIP18 family.

9544:CCNDBP1
gene id: 9544:CCNDBP1
uniprot id: A0A5K1U6E5
uniprot id: H9FS83
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

9544:LIAS
gene id: 9544:LIAS
uniprot id: A0A8J8XVD6
uniprot id: F6RMC6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9544:TBCB
gene id: 9544:TBCB
uniprot id: H9EMA0
names: Similarity
messages: Belongs to the TBCB family.

9544:DGKK
gene id: 9544:DGKK
uniprot id: A0A1D5R8J9
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9544:PPP1R12A
gene id: 9544:PPP1R12A
uniprot id: I0FRY0
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9544:CDC25C
gene id: 9544:CDC25C
uniprot id: F7FH10
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9544:CAT
gene id: 9544:CAT
uniprot id: F6PLF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

9544:PSMB4
gene id: 9544:PSMB4
uniprot id: A0A8J8XEB4
uniprot id: F7H4P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9544:MRPL40
gene id: 9544:MRPL40
uniprot id: F7GN40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9544:FGFR1
gene id: 9544:FGFR1
uniprot id: A0A1D5Q279
uniprot id: F7A4R9
uniprot id: G7MZ50
uniprot id: H9FRD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9544:CDK5R2
gene id: 9544:CDK5R2
uniprot id: F7CY39
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

9544:CDH6
gene id: 9544:CDH6
uniprot id: G7MUQ7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:OR10Q1
gene id: 9544:OR10Q1
uniprot id: A0A5F8A795
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ORC2
gene id: 9544:ORC2
uniprot id: A0A8J8YDW6
uniprot id: F7BAH4
uniprot id: G7N8M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9544:TDO2
gene id: 9544:TDO2
uniprot id: F6RBA2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:WRB
gene id: 9544:WRB
uniprot id: H9ZD81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:RPS2
gene id: 9544:RPS2
uniprot id: A0A8J8XTU3
uniprot id: G7NQT9
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9544:HDAC4
gene id: 9544:HDAC4
uniprot id: F6VW34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9544:USP9X
gene id: 9544:USP9X
uniprot id: A0A5K1TXP1
uniprot id: F6RFN9
uniprot id: H9YUQ6
names: Similarity
messages: Belongs to the peptidase C19 family.

9544:RRP7A
gene id: 9544:RRP7A
uniprot id: H9Z0Y3
names: Similarity
messages: Belongs to the RRP7 family.

9544:RDH12
gene id: 9544:RDH12
uniprot id: A0A8J8YMJ1
uniprot id: F7C217
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:AQP1
gene id: 9544:AQP1
uniprot id: G7MLJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9544:HIGD2A
gene id: 9544:HIGD2A
uniprot id: A0A8J8YCP1
uniprot id: F7HLT1
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9544:UBE2K
gene id: 9544:UBE2K
uniprot id: A0A8J8YDV8
uniprot id: F6UEX6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:FAM49A
gene id: 9544:FAM49A
uniprot id: A0A8J8Y8L7
uniprot id: F6UFH8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9544:GGPS1
gene id: 9544:GGPS1
uniprot id: A0A8J8Y0M1
uniprot id: F7DMS6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9544:IMP4
gene id: 9544:IMP4
uniprot id: A0A8J8Y7R3
uniprot id: F6ZZ93
names: Subcellular Location Annotation
messages: nucleolus

9544:MRPL36
gene id: 9544:MRPL36
uniprot id: H9H300
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9544:SLC51A
gene id: 9544:SLC51A
uniprot id: F7GU27
names: Subcellular Location Annotation
messages: Membrane

9544:SYNDIG1L
gene id: 9544:SYNDIG1L
uniprot id: A0A8J8YR75
uniprot id: G7MYT0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:ARSI
gene id: 9544:ARSI
uniprot id: A0A8J8XWZ0
uniprot id: F7BMK9
names: Similarity
messages: Belongs to the sulfatase family.

9544:ZFP36
gene id: 9544:ZFP36
uniprot id: A0A1D5Q4Y1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9544:HTR3A
gene id: 9544:HTR3A
uniprot id: F7ES27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane

9544:SF3A3
gene id: 9544:SF3A3
uniprot id: A0A8J8XEF9
uniprot id: G7MFY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

9544:ERBB2
gene id: 9544:ERBB2
uniprot id: F7D6W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9544:BANF1
gene id: 9544:BANF1
uniprot id: F6T830
names: Subcellular Location Annotation
messages: Nucleus

9544:PNPT1
gene id: 9544:PNPT1
uniprot id: F7DK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm

9544:BLOC1S6
gene id: 9544:BLOC1S6
uniprot id: G7MX85
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9544:MFAP2
gene id: 9544:MFAP2
uniprot id: A0A5F8AIN0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:GRB7
gene id: 9544:GRB7
uniprot id: F7HC81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9544:PDE7B
gene id: 9544:PDE7B
uniprot id: A0A1D5Q7I6
uniprot id: F7GN31
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:GNA13
gene id: 9544:GNA13
uniprot id: H9EP41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9544:CFAP97
gene id: 9544:CFAP97
uniprot id: H9FXP3
names: Similarity
messages: Belongs to the CFAP97 family.

9544:EXOC7
gene id: 9544:EXOC7
uniprot id: A0A5F7ZFP9
uniprot id: F7DT66
uniprot id: H9FRW4
uniprot id: H9FRW5
uniprot id: H9FRW6
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9544:SMIM24
gene id: 9544:SMIM24
uniprot id: F7CUU7
names: Subcellular Location Annotation
messages: Membrane

9544:PAPOLG
gene id: 9544:PAPOLG
uniprot id: A0A5K1TWB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

9544:SLC6A3
gene id: 9544:SLC6A3
uniprot id: A0A8J8XR80
uniprot id: Q7JHP8
uniprot id: Q7JHP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
messages: Cell membrane
messages: Membrane
messages: axon
messages: neuron projection

9544:TMOD1
gene id: 9544:TMOD1
uniprot id: A0A1D5RHC4
uniprot id: A0A8J8YIH1
names: Subcellular Location Annotation
messages: cytoskeleton

9544:TOR1AIP2
gene id: 9544:TOR1AIP2
uniprot id: A0A8J8YL16
uniprot id: F7CN35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9544:SYP
gene id: 9544:SYP
uniprot id: I2CYU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9544:RPL27A
gene id: 9544:RPL27A
uniprot id: F7EMH2
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9544:SERINC2
gene id: 9544:SERINC2
uniprot id: A0A5K1VD29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9544:TSEN34
gene id: 9544:TSEN34
uniprot id: F7H3C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9544:PRPF38B
gene id: 9544:PRPF38B
uniprot id: A0A8J8XX64
uniprot id: F6QPW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9544:CYP2C93
gene id: 9544:CYP2C93
uniprot id: F1ADG8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:ALDH3A2
gene id: 9544:ALDH3A2
uniprot id: A0A1D5QV70
uniprot id: F7C1B5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:C13H2orf70
gene id: 9544:C13H2orf70
uniprot id: A0A8J8XUM8
uniprot id: F7BSP8
names: Similarity
messages: Belongs to the CIMIP2 family.

9544:EPS8L2
gene id: 9544:EPS8L2
uniprot id: F6VIA6
names: Similarity
messages: Belongs to the EPS8 family.

9544:LOC704239
gene id: 9544:LOC704239
uniprot id: A0A5F8A6L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9544:EXOC3
gene id: 9544:EXOC3
uniprot id: A0A8J8YD84
uniprot id: G7MU42
names: Similarity
messages: Belongs to the SEC6 family.

9544:TRIM5
gene id: 9544:TRIM5
uniprot id: Q0PF16
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation.
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with MAP3K7/TAK1, TAB2 and TAB3 (By similarity). Interacts with HSPA8/HSC70, PSMC2, PSMC4, PSMC5 and PSMD7 (PubMed:20053985, PubMed:22078707). Interacts with SQSTM1 (PubMed:20357094, PubMed:25127057). Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with TRIM6 and TRIM34 (PubMed:21680743). Interacts with BECN1; GABARAP (PubMed:25127057). Interacts with ULK1 (phosphorylated form), GABARAPL1, GABARAPL2, MAP1LC3A and MAP1LC3C (By similarity).
messages: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV-agm). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).
messages: Cytoplasm
messages: Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.
messages: Nucleus
messages: The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity (By similarity). The coiled coil domain is important for higher order multimerization by promoting the initial dimerization (PubMed:21680743).
messages: The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs.
messages: The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization.

9544:SVOPL
gene id: 9544:SVOPL
uniprot id: F7F4K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9544:STAT2
gene id: 9544:STAT2
uniprot id: A0A8J8YRP5
uniprot id: F6R1P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9544:PRSS23
gene id: 9544:PRSS23
uniprot id: Q1WK23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Secreted

9544:MFF
gene id: 9544:MFF
uniprot id: A0A5F7ZEV4
uniprot id: A0A5F7ZRM2
uniprot id: A0A5F8AHI1
uniprot id: F6ZK26
uniprot id: F6ZK35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
messages: synaptic vesicle

9544:ATP13A3
gene id: 9544:ATP13A3
uniprot id: A0A8J8YJ59
uniprot id: F7GWI3
uniprot id: G7MKA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9544:GOLM1
gene id: 9544:GOLM1
uniprot id: F7FX41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9544:NT5C2
gene id: 9544:NT5C2
uniprot id: A0A8J8XPF3
uniprot id: F7FIW4
uniprot id: F7GXG1
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9544:TAS2R40
gene id: 9544:TAS2R40
uniprot id: A0A8J8XPX9
uniprot id: Q645S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:TOB1
gene id: 9544:TOB1
uniprot id: A0A8J8XZV8
uniprot id: F7GFK0
names: Similarity
messages: Belongs to the BTG family.

9544:SS18L1
gene id: 9544:SS18L1
uniprot id: H9FSQ5
names: Similarity
messages: Belongs to the SS18 family.

9544:EXOC1
gene id: 9544:EXOC1
uniprot id: A0A8J8XPZ5
uniprot id: F7F553
uniprot id: H9FX21
uniprot id: H9YUY3
names: Similarity
messages: Belongs to the SEC3 family.

9544:NKD1
gene id: 9544:NKD1
uniprot id: F7GTC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm

9544:TSPO
gene id: 9544:TSPO
uniprot id: A0A8J8Y0Z2
uniprot id: F6WA72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9544:LPCAT3
gene id: 9544:LPCAT3
uniprot id: A0A8J8YKW5
uniprot id: G7N5U7
names: Subcellular Location Annotation
messages: Membrane

9544:IDH2
gene id: 9544:IDH2
uniprot id: I0FRE5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.

9544:PTPRM
gene id: 9544:PTPRM
uniprot id: A0A5K1V8J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9544:AIG1
gene id: 9544:AIG1
uniprot id: A0A1D5QKR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9544:RPL30
gene id: 9544:RPL30
uniprot id: F7GQT7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9544:RPS27L
gene id: 9544:RPS27L
uniprot id: H9FV62
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9544:RPL37
gene id: 9544:RPL37
uniprot id: F7HR63
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9544:LIPJ
gene id: 9544:LIPJ
uniprot id: F7CTG9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9544:EMC6
gene id: 9544:EMC6
uniprot id: A0A8J8YQY6
uniprot id: F7E3H9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ART4
gene id: 9544:ART4
uniprot id: G7N6E9
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9544:TACC2
gene id: 9544:TACC2
uniprot id: I2CYB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9544:LOC716363
gene id: 9544:LOC716363
uniprot id: G7NEL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:SUV39H2
gene id: 9544:SUV39H2
uniprot id: F7GYV0
uniprot id: F7GYV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9544:UNC5C
gene id: 9544:UNC5C
uniprot id: F7HIS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9544:SLC31A2
gene id: 9544:SLC31A2
uniprot id: A0A5F7ZX39
uniprot id: F7HLP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:VIPR1
gene id: 9544:VIPR1
uniprot id: A0A1D5R219
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9544:SLC16A4
gene id: 9544:SLC16A4
uniprot id: A0A8J8Y4G2
uniprot id: I2CXU9
names: Subcellular Location Annotation
messages: Membrane

9544:SFTPD
gene id: 9544:SFTPD
uniprot id: G7N227
uniprot id: Q1PBC5
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPD family.
messages: Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties (By similarity).
messages: Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
messages: Oligomeric complex of 4 set of homotrimers.
messages: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
messages: S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.
messages: extracellular matrix
messages: surface film

9544:PTS
gene id: 9544:PTS
uniprot id: I2CVZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9544:GALK1
gene id: 9544:GALK1
uniprot id: A0A5F7Z8J5
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9544:TRMT2B
gene id: 9544:TRMT2B
uniprot id: F6UTK6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:STC1
gene id: 9544:STC1
uniprot id: A0A8J8Y0F9
uniprot id: F7DYS7
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9544:OXTR
gene id: 9544:OXTR
uniprot id: P56494
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9544:TCEA3
gene id: 9544:TCEA3
uniprot id: I0FI55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9544:SNAP23
gene id: 9544:SNAP23
uniprot id: A0A1D5QYR9
uniprot id: A0A8J8Y055
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9544:RHBDL2
gene id: 9544:RHBDL2
uniprot id: H9FWA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9544:LOC705939
gene id: 9544:LOC705939
uniprot id: F7FXM2
names: Similarity
messages: Belongs to the intermediate filament family.

9544:CNNM1
gene id: 9544:CNNM1
uniprot id: A0A5F7Z9S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9544:HIKESHI
gene id: 9544:HIKESHI
uniprot id: A0A8J8XHK1
uniprot id: F7F804
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9544:CNTNAP2
gene id: 9544:CNTNAP2
uniprot id: F6QIU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: paranodal septate junction

9544:CNP
gene id: 9544:CNP
uniprot id: H9Z590
uniprot id: Q3LRT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

9544:MAMU-DPA
gene id: 9544:MAMU-DPA
uniprot id: A2TJ58
uniprot id: Q18PF3
uniprot id: S6DFB2
names: Similarity
messages: Belongs to the MHC class II family.

9544:EPS8
gene id: 9544:EPS8
uniprot id: H9FR47
names: Similarity
messages: Belongs to the EPS8 family.

9544:PAGE3
gene id: 9544:PAGE3
uniprot id: F6RHF3
names: Similarity
messages: Belongs to the GAGE family.

9544:DBNDD1
gene id: 9544:DBNDD1
uniprot id: F6X5B9
names: Similarity
messages: Belongs to the dysbindin family.

9544:KRTCAP2
gene id: 9544:KRTCAP2
uniprot id: A0A8J8YST1
uniprot id: F7HTS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9544:CER1
gene id: 9544:CER1
uniprot id: A0A8J8YHW6
uniprot id: F7DJA6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:P3H2
gene id: 9544:P3H2
uniprot id: I0FT21
names: Similarity
messages: Belongs to the leprecan family.

9544:C19H19orf24
gene id: 9544:C19H19orf24
uniprot id: F7DU96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9544:RNF34
gene id: 9544:RNF34
uniprot id: A0A1D5R1K1
uniprot id: I2CYW0
names: Subcellular Location Annotation
messages: Cell membrane
messages: cytosol

9544:GCNT2
gene id: 9544:GCNT2
uniprot id: F6Z9P4
uniprot id: G7MQJ9
uniprot id: H9H454
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9544:APMAP
gene id: 9544:APMAP
uniprot id: A0A8J8XRN0
uniprot id: G7N355
names: Similarity
messages: Belongs to the strictosidine synthase family.

9544:SGK1
gene id: 9544:SGK1
uniprot id: A0A5K1VLQ6
uniprot id: F7GPM7
uniprot id: I0FU80
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9544:GPAM
gene id: 9544:GPAM
uniprot id: A0A5K1UAI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9544:S1PR3
gene id: 9544:S1PR3
uniprot id: A0A8J8Y812
uniprot id: G7NEM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:NDUFB6
gene id: 9544:NDUFB6
uniprot id: A0A1D5QZD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:LMNB1
gene id: 9544:LMNB1
uniprot id: I2CV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9544:TADA2A
gene id: 9544:TADA2A
uniprot id: A0A8J8XQ07
uniprot id: G7NI12
names: Subcellular Location Annotation
messages: Nucleus

9544:SSU72
gene id: 9544:SSU72
uniprot id: H9ENB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9544:CYB5RL
gene id: 9544:CYB5RL
uniprot id: A0A8J8YDX9
uniprot id: F7DD80
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9544:MELK
gene id: 9544:MELK
uniprot id: H9Z026
uniprot id: I2CVB0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9544:PURB
gene id: 9544:PURB
uniprot id: I2CY42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9544:AURKB
gene id: 9544:AURKB
uniprot id: A0A8J8Y9R5
uniprot id: F6VVA5
uniprot id: G7NIN9
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

9544:YES1
gene id: 9544:YES1
uniprot id: F6ZR07
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9544:SGMS2
gene id: 9544:SGMS2
uniprot id: A0A8J8YDE5
uniprot id: F7DR07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9544:FBXO34
gene id: 9544:FBXO34
uniprot id: A0A8J8XVM6
uniprot id: H9FWF4
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9544:NNMT
gene id: 9544:NNMT
uniprot id: A0A8J8YMH4
uniprot id: F7ERX8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9544:KEG06 p05
gene id: 9544:KEG06_p05
uniprot id: I3W8K6
uniprot id: Q6IYH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9544:SHCBP1L
gene id: 9544:SHCBP1L
uniprot id: F6WVF4
names: Subcellular Location Annotation
messages: spindle

9544:DHRS7B
gene id: 9544:DHRS7B
uniprot id: A0A5K1UPY0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:UTP3
gene id: 9544:UTP3
uniprot id: G7MT50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

9544:PFKFB3
gene id: 9544:PFKFB3
uniprot id: F7CG95
uniprot id: H9FVS7
uniprot id: H9FVS8
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9544:NME4
gene id: 9544:NME4
uniprot id: H9EW45
names: Similarity
messages: Belongs to the NDK family.

9544:SLC9A6
gene id: 9544:SLC9A6
uniprot id: F6WNU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9544:ZDHHC24
gene id: 9544:ZDHHC24
uniprot id: H9ESD7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:SUMO2
gene id: 9544:SUMO2
uniprot id: H9EN62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9544:SMG9
gene id: 9544:SMG9
uniprot id: A0A5F7ZW06
uniprot id: F6Z1W2
names: Similarity
messages: Belongs to the SMG9 family.

9544:JUP
gene id: 9544:JUP
uniprot id: A0A8J8YGS1
uniprot id: G7NIJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9544:ATP6V1G1
gene id: 9544:ATP6V1G1
uniprot id: F6Z8T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9544:STAR
gene id: 9544:STAR
uniprot id: I2CUU5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9544:BCL7B
gene id: 9544:BCL7B
uniprot id: A0A1D5REN6
names: Similarity
messages: Belongs to the BCL7 family.

9544:ZDHHC1
gene id: 9544:ZDHHC1
uniprot id: F6WYM4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:HCN1
gene id: 9544:HCN1
uniprot id: F6TMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9544:POPDC3
gene id: 9544:POPDC3
uniprot id: A0A8J8XWB6
uniprot id: F7GJR7
names: Similarity
messages: Belongs to the popeye family.

9544:KCNG3
gene id: 9544:KCNG3
uniprot id: F6YEM0
uniprot id: H9Z5X1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:PCLAF
gene id: 9544:PCLAF
uniprot id: A0A8J8Y203
uniprot id: F7G277
uniprot id: G7MXT3
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

9544:LOC722133
gene id: 9544:LOC722133
uniprot id: H9FZ50
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SLC35B3
gene id: 9544:SLC35B3
uniprot id: H9FV50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9544:ELSPBP1
gene id: 9544:ELSPBP1
uniprot id: D1YSI4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:IFNA10
gene id: 9544:IFNA10
uniprot id: A0A5F8A6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:ZHX3
gene id: 9544:ZHX3
uniprot id: A0A5F7ZSW7
uniprot id: F7AY06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9544:PIK3CD
gene id: 9544:PIK3CD
uniprot id: H9ZA48
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9544:SPNS2
gene id: 9544:SPNS2
uniprot id: A0A5F7ZI39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9544:SFT2D1
gene id: 9544:SFT2D1
uniprot id: A0A8J8YPP4
uniprot id: F7GWZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9544:C15H9orf64
gene id: 9544:C15H9orf64
uniprot id: F6WZW8
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

9544:DECR2
gene id: 9544:DECR2
uniprot id: F6WJI8
uniprot id: I2CVE4
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

9544:STX1A
gene id: 9544:STX1A
uniprot id: Q9N0X9
names: Similarity
messages: Belongs to the syntaxin family.

9544:JUNB
gene id: 9544:JUNB
uniprot id: H9Z2E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9544:UNK
gene id: 9544:UNK
uniprot id: A0A8J8XEJ6
uniprot id: F7GKT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9544:BCAN
gene id: 9544:BCAN
uniprot id: H9FYA2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:IRF1
gene id: 9544:IRF1
uniprot id: A0A1D5QDW4
uniprot id: A0A8J8YKS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9544:GPN2
gene id: 9544:GPN2
uniprot id: A0A8J8XLZ5
uniprot id: F6YBW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9544:CCR6
gene id: 9544:CCR6
uniprot id: F6VQA9
uniprot id: Q8HZR7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:CCNE2
gene id: 9544:CCNE2
uniprot id: F6Q7B1
names: Similarity
messages: Belongs to the cyclin family.

9544:LOC698176
gene id: 9544:LOC698176
uniprot id: F7HFG9
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

9544:GATM
gene id: 9544:GATM
uniprot id: G7MX82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain.

9544:GPX7
gene id: 9544:GPX7
uniprot id: A0A5F8AIN7
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9544:COPB2
gene id: 9544:COPB2
uniprot id: H9EP74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

9544:ITIH1
gene id: 9544:ITIH1
uniprot id: F7GAT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9544:SIRT5
gene id: 9544:SIRT5
uniprot id: F7EZ75
uniprot id: G7MQR7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: Monomer. Homodimer. Interacts with CPS1. Interacts with PCCA (By similarity).
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

9544:ADRA1A
gene id: 9544:ADRA1A
uniprot id: A0A1D5RF92
uniprot id: B0S4P2
uniprot id: B0S4P6
uniprot id: G7N0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9544:CCDC65
gene id: 9544:CCDC65
uniprot id: F7DVF7
names: Subcellular Location Annotation
messages: flagellum axoneme

9544:F11R
gene id: 9544:F11R
uniprot id: F6WSS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9544:PDLIM1
gene id: 9544:PDLIM1
uniprot id: F6YRD0
names: Subcellular Location Annotation
messages: Z line

9544:TSHR
gene id: 9544:TSHR
uniprot id: Q8HY53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

9544:NSA2
gene id: 9544:NSA2
uniprot id: H9Z4B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9544:SMCO4
gene id: 9544:SMCO4
uniprot id: A0A8J8XHB9
uniprot id: F7H3Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMCO4 family.
messages: Membrane

9544:FBP2
gene id: 9544:FBP2
uniprot id: A0A5F7ZFX7
uniprot id: F6YGD4
names: Similarity
messages: Belongs to the FBPase class 1 family.

9544:CYP2C8
gene id: 9544:CYP2C8
uniprot id: Q6GUQ7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:USP21
gene id: 9544:USP21
uniprot id: A0A8J8YDY1
uniprot id: F6WTH2
uniprot id: G7ME91
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:NKG2D
gene id: 9544:NKG2D
uniprot id: H9Z6I9
uniprot id: Q9MZJ7
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins (By similarity).
messages: Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Can form disulfide-bonded heterodimer with CD94 (By similarity). Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (By similarity).
messages: Is not capable of signal transduction by itself, but operates through the adapter protein HCST.
messages: Natural killer cells.

9544:SNUPN
gene id: 9544:SNUPN
uniprot id: H9FND9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

9544:ANO5
gene id: 9544:ANO5
uniprot id: A0A5K1VUK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9544:GDA
gene id: 9544:GDA
uniprot id: F7CWS1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9544:C9H10orf53
gene id: 9544:C9H10orf53
uniprot id: A0A1D5RK91
names: Similarity
messages: Belongs to the UPF0728 family.

9544:JPH4
gene id: 9544:JPH4
uniprot id: F6XJV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9544:PRKX
gene id: 9544:PRKX
uniprot id: H9ZBB2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:FAM72A
gene id: 9544:FAM72A
uniprot id: A0A8J8YB63
uniprot id: G7MER7
names: Similarity
messages: Belongs to the FAM72 family.

9544:TUBB4A
gene id: 9544:TUBB4A
uniprot id: A0A1D5QPK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9544:CSGALNACT1
gene id: 9544:CSGALNACT1
uniprot id: A0A8J8XJF8
uniprot id: F7H635
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9544:NPY
gene id: 9544:NPY
uniprot id: A0A8J8YAR8
uniprot id: G7MLN4
uniprot id: Q9XSW6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
messages: Secreted
messages: The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
messages: neuronal dense core vesicle

9544:MRFAP1L1
gene id: 9544:MRFAP1L1
uniprot id: A0A8J8YRT6
uniprot id: F6PXI9
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9544:PFDN4
gene id: 9544:PFDN4
uniprot id: A0A1D5RGY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9544:FAM192A
gene id: 9544:FAM192A
uniprot id: A0A8J8YFW3
uniprot id: G7NPT8
names: Subcellular Location Annotation
messages: Nucleus

9544:CCT8
gene id: 9544:CCT8
uniprot id: A0A1D5RFA5
uniprot id: H9Z4I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: cilium basal body

9544:NDUFV3
gene id: 9544:NDUFV3
uniprot id: H9FUU4
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

9544:GPX3
gene id: 9544:GPX3
uniprot id: I0FR18
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9544:GIMAP8
gene id: 9544:GIMAP8
uniprot id: G7MNA2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9544:RAB14
gene id: 9544:RAB14
uniprot id: A0A8J8XPE6
uniprot id: F7G3Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9544:LOC695427
gene id: 9544:LOC695427
uniprot id: A0A8J8Y153
uniprot id: F7BRX2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:DOK2
gene id: 9544:DOK2
uniprot id: A0A5K1UDG9
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9544:KCTD4
gene id: 9544:KCTD4
uniprot id: A0A8J8YLX8
uniprot id: F7F064
names: Subcellular Location Annotation
messages: Cell membrane

9544:ATP1A3
gene id: 9544:ATP1A3
uniprot id: F7HPP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9544:PSAP
gene id: 9544:PSAP
uniprot id: F7GVI7
names: Function
names: Subcellular Location Annotation
messages: Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Secreted

9544:SEPTIN12
gene id: 9544:SEPTIN12
uniprot id: A0A8J8YNF5
uniprot id: F7EM27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9544:VLDLR
gene id: 9544:VLDLR
uniprot id: F6WNM1
uniprot id: Q6S4M1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:NR2F6
gene id: 9544:NR2F6
uniprot id: F6Z4E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:GLO1
gene id: 9544:GLO1
uniprot id: A0A8J8YFN9
uniprot id: F7GRZ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9544:NIT2
gene id: 9544:NIT2
uniprot id: I0FTK4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9544:NLRP5
gene id: 9544:NLRP5
uniprot id: B0FNB0
names: Similarity
messages: Belongs to the NLRP family.

9544:AKAP8L
gene id: 9544:AKAP8L
uniprot id: F7DN43
uniprot id: H9FSX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKAP95 family.
messages: Nucleus matrix

9544:SNRPG
gene id: 9544:SNRPG
uniprot id: H9FNB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9544:GRK6
gene id: 9544:GRK6
uniprot id: A0A5F8A9L1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9544:TCF19
gene id: 9544:TCF19
uniprot id: Q5TM48
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

9544:MRPL35
gene id: 9544:MRPL35
uniprot id: H9H472
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9544:OTULINL
gene id: 9544:OTULINL
uniprot id: F6VX07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9544:LHPP
gene id: 9544:LHPP
uniprot id: A0A1D5QVA2
uniprot id: F7ERE1
uniprot id: H9EW11
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9544:SFXN3
gene id: 9544:SFXN3
uniprot id: A0A5F7ZU85
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9544:PPP1R15A
gene id: 9544:PPP1R15A
uniprot id: A0A1D5R262
names: Similarity
messages: Belongs to the PPP1R15 family.

9544:GRIA2
gene id: 9544:GRIA2
uniprot id: A0A5F7Z7T5
uniprot id: A0A5F7ZWW1
uniprot id: F7HM86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:RDH10
gene id: 9544:RDH10
uniprot id: I2CWI5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:SVBP
gene id: 9544:SVBP
uniprot id: A0A8J8YLG6
uniprot id: F7EAA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

9544:F9
gene id: 9544:F9
uniprot id: A8CZ27
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:CALR
gene id: 9544:CALR
uniprot id: A0A8J8XPG4
uniprot id: G7NLC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9544:MUSTN1
gene id: 9544:MUSTN1
uniprot id: F7GAF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9544:GNGT2
gene id: 9544:GNGT2
uniprot id: A0A8J8YHI8
uniprot id: F6PKY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:ARL8B
gene id: 9544:ARL8B
uniprot id: F7F1D7
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: axon
messages: spindle

9544:HDAC1
gene id: 9544:HDAC1
uniprot id: H9Z897
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9544:PGK1
gene id: 9544:PGK1
uniprot id: I0FSL5
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9544:MBOAT1
gene id: 9544:MBOAT1
uniprot id: F7HPV2
names: Subcellular Location Annotation
messages: Membrane

9544:XPO6
gene id: 9544:XPO6
uniprot id: H9FRV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9544:EXOSC2
gene id: 9544:EXOSC2
uniprot id: G7NFJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9544:DMRTC2
gene id: 9544:DMRTC2
uniprot id: G7NLK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9544:TAF5L
gene id: 9544:TAF5L
uniprot id: F6YMW6
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9544:STAC
gene id: 9544:STAC
uniprot id: A0A1D5RIY5
names: Subcellular Location Annotation
messages: sarcolemma

9544:CFAP97D1
gene id: 9544:CFAP97D1
uniprot id: A0A8J8YL57
uniprot id: F6PMF1
names: Similarity
messages: Belongs to the CFAP97 family.

9544:ZHX1
gene id: 9544:ZHX1
uniprot id: A0A8J8XZ52
uniprot id: F6WB25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9544:PHF1
gene id: 9544:PHF1
uniprot id: A0A1D5R364
uniprot id: A0A8J8YP53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9544:CLTC
gene id: 9544:CLTC
uniprot id: F7B8E8
uniprot id: I0FP57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9544:CDK4
gene id: 9544:CDK4
uniprot id: A0A8J8Y3N2
uniprot id: I0FIZ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:GSTA4
gene id: 9544:GSTA4
uniprot id: A0A1D5QV65
uniprot id: A0A8J8XRE3
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9544:SDR9C7
gene id: 9544:SDR9C7
uniprot id: A0A8J8XEK2
uniprot id: G7N7E1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:RAMP1
gene id: 9544:RAMP1
uniprot id: H9YXZ4
names: Similarity
messages: Belongs to the RAMP family.

9544:FMO1
gene id: 9544:FMO1
uniprot id: A0A023JCF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:LMX1B
gene id: 9544:LMX1B
uniprot id: F6VZX1
names: Subcellular Location Annotation
messages: Nucleus

9544:EDEM1
gene id: 9544:EDEM1
uniprot id: F7F1M7
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9544:KCNK3
gene id: 9544:KCNK3
uniprot id: I2CUN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9544:ELOVL4
gene id: 9544:ELOVL4
uniprot id: A0A8J8XYA6
uniprot id: G7MPS8
uniprot id: Q3S8M4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: N-glycosylated.
messages: Oligomer.
messages: The C-terminal di-lysine motif confers endoplasmic reticulum localization.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9544:GPM6A
gene id: 9544:GPM6A
uniprot id: A0A1D5QPT8
uniprot id: A0A8J8YED2
uniprot id: G7MSC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9544:GADD45GIP1
gene id: 9544:GADD45GIP1
uniprot id: A0A8J8XEB7
uniprot id: G7NLC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

9544:DIPK1B
gene id: 9544:DIPK1B
uniprot id: A0A5F8AIA2
names: Similarity
messages: Belongs to the DIPK family.

9544:SNU13
gene id: 9544:SNU13
uniprot id: H9FUW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9544:SNAP25
gene id: 9544:SNAP25
uniprot id: A0A8J8YQA7
uniprot id: G7N2Y7
uniprot id: I2CXZ2
uniprot id: P60877
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association (By similarity).
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex constitutes the basic catalytic machinery of the complex neurotransmitter release apparatus (By similarity). Recruited to the SNARE complex following binding of the SNARE complex component STX1A to STXBP1 (By similarity). This complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8 (By similarity). Interacts with HSC70 and with SYT9, forming a complex with DNAJC5 (By similarity). The interaction with SYT9 is inhibited in presence of calcium (By similarity). Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex (By similarity). Interacts with PLCL1 (via C2 domain) (By similarity). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex (By similarity). Interacts with alpha-synuclein/SNCA (By similarity). Interacts with PRPH2 (By similarity). Interacts with ROM1 (By similarity). Interacts with STX3 (By similarity).
messages: Photoreceptor inner segment
messages: perinuclear region
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9544:EDNRA
gene id: 9544:EDNRA
uniprot id: A0A8J8YLD3
uniprot id: I0FJM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9544:NSF
gene id: 9544:NSF
uniprot id: A0A1D5R978
uniprot id: F6YT14
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9544:DDX4
gene id: 9544:DDX4
uniprot id: A0A8J8XM58
uniprot id: F7H4I4
names: Similarity
messages: Belongs to the DEAD box helicase family.

9544:HACD3
gene id: 9544:HACD3
uniprot id: A0A8J8Y7A3
uniprot id: G7MXU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:NCAPG
gene id: 9544:NCAPG
uniprot id: H9YWY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9544:TAGLN3
gene id: 9544:TAGLN3
uniprot id: A0A8J8Y7B5
uniprot id: G7MK53
names: Similarity
messages: Belongs to the calponin family.

9544:AP1S3
gene id: 9544:AP1S3
uniprot id: F7A390
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9544:PRDX2
gene id: 9544:PRDX2
uniprot id: A0A8J8XBE4
uniprot id: G7NLB5
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9544:DSTYK
gene id: 9544:DSTYK
uniprot id: Q20CR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm

9544:LYZL6
gene id: 9544:LYZL6
uniprot id: A0A8J8XDR6
uniprot id: F7FCQ1
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

9544:RPL23A
gene id: 9544:RPL23A
uniprot id: F7HIX4
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9544:STXBP1
gene id: 9544:STXBP1
uniprot id: A0A1D5Q217
uniprot id: F7FLD8
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9544:PRKACG
gene id: 9544:PRKACG
uniprot id: A0A8J8XKD6
uniprot id: F6UGA5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9544:INSM2
gene id: 9544:INSM2
uniprot id: F7G7V4
names: Subcellular Location Annotation
messages: Nucleus

9544:MRPS18B
gene id: 9544:MRPS18B
uniprot id: A0A5S7WSP6
uniprot id: H9EXU2
uniprot id: Q5TM62
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

9544:SRPRB
gene id: 9544:SRPRB
uniprot id: A0A8J8XMY9
uniprot id: F7DHR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:SCG5
gene id: 9544:SCG5
uniprot id: A0A8J8XJA7
uniprot id: F7HSR5
uniprot id: I0FU81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9544:HIST1H2BM
gene id: 9544:HIST1H2BM
uniprot id: A0A8J8YQ31
uniprot id: G7MR89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:TRIM26
gene id: 9544:TRIM26
uniprot id: A0A8J8YFF0
uniprot id: Q5TM56
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:CDKN2AIP
gene id: 9544:CDKN2AIP
uniprot id: A0A8J8Y863
uniprot id: H9YUZ2
names: Similarity
messages: Belongs to the CARF family.

9544:PGLYRP3
gene id: 9544:PGLYRP3
uniprot id: A0A8J8YSC1
uniprot id: F6YQC2
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9544:NPBWR2
gene id: 9544:NPBWR2
uniprot id: F7GGP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:LCA5L
gene id: 9544:LCA5L
uniprot id: F7D2V2
names: Similarity
messages: Belongs to the LCA5 family.

9544:DCTN4
gene id: 9544:DCTN4
uniprot id: A0A8J8Y2J8
uniprot id: G7MVN0
uniprot id: H9Z105
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: cell cortex
messages: centrosome
messages: sarcomere
messages: stress fiber

9544:NKX2-8
gene id: 9544:NKX2-8
uniprot id: G7MXM3
names: Subcellular Location Annotation
messages: Nucleus

9544:RIN2
gene id: 9544:RIN2
uniprot id: A0A1D5R6Z1
uniprot id: F6R6N9
uniprot id: F6T985
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9544:CACNG5
gene id: 9544:CACNG5
uniprot id: A0A5F7ZJV6
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

9544:PSMF1
gene id: 9544:PSMF1
uniprot id: G7N2Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9544:PGM2
gene id: 9544:PGM2
uniprot id: H9EV43
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9544:ADAM10
gene id: 9544:ADAM10
uniprot id: H9EQI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SNTA1
gene id: 9544:SNTA1
uniprot id: H9FYU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9544:BMP7
gene id: 9544:BMP7
uniprot id: A0A8J8XHT8
uniprot id: F6ZJT0
names: Similarity
messages: Belongs to the TGF-beta family.

9544:MTNR1A
gene id: 9544:MTNR1A
uniprot id: F7ER13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9544:MPHOSPH10
gene id: 9544:MPHOSPH10
uniprot id: H9FNJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9544:LMBR1L
gene id: 9544:LMBR1L
uniprot id: A0A5K1UXT6
names: Similarity
messages: Belongs to the LIMR family.

9544:MC4R
gene id: 9544:MC4R
uniprot id: A0A8J8XAD5
uniprot id: F7GYJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9544:TAAR1
gene id: 9544:TAAR1
uniprot id: Q8HZ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity).

9544:BRCC3
gene id: 9544:BRCC3
uniprot id: H9EN35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9544:YKT6
gene id: 9544:YKT6
uniprot id: A0A8J8XVB6
uniprot id: F6PLE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9544:CERS6
gene id: 9544:CERS6
uniprot id: F7CYG3
uniprot id: F7FW69
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9544:FMO3
gene id: 9544:FMO3
uniprot id: F7HQX7
uniprot id: Q8SPQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Liver.
messages: Membrane
messages: Microsome membrane

9544:DMTF1
gene id: 9544:DMTF1
uniprot id: F7GUY9
uniprot id: H9G2P6
names: Subcellular Location Annotation
messages: Nucleus

9544:IL17RB
gene id: 9544:IL17RB
uniprot id: A0A8J8YAC0
uniprot id: F7HL00
uniprot id: G7ML21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:FN3K
gene id: 9544:FN3K
uniprot id: A0A5K1V2Q8
names: Similarity
messages: Belongs to the fructosamine kinase family.

9544:MED17
gene id: 9544:MED17
uniprot id: A0A8J8XS28
uniprot id: H9ETD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:SLC8A3
gene id: 9544:SLC8A3
uniprot id: A0A5F7ZQW5
uniprot id: A0A5F7ZTI2
uniprot id: F7HMP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9544:PDK3
gene id: 9544:PDK3
uniprot id: I0FSI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9544:B4GALT6
gene id: 9544:B4GALT6
uniprot id: A0A8J8XZC1
uniprot id: F7CF81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9544:RND3
gene id: 9544:RND3
uniprot id: A0A8J8XH00
uniprot id: F7FMR3
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9544:TMEM59
gene id: 9544:TMEM59
uniprot id: H9ZFL4
uniprot id: I0FWL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:H1FX
gene id: 9544:H1FX
uniprot id: F6Z1X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9544:ERGIC1
gene id: 9544:ERGIC1
uniprot id: A0A5K1UES3
uniprot id: F6V791
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9544:LOC106995433
gene id: 9544:LOC106995433
uniprot id: A0A1D5QJ99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9544:NNAT
gene id: 9544:NNAT
uniprot id: A0A5F8AAQ1
uniprot id: F6SKN9
uniprot id: G8F239
names: Similarity
messages: Belongs to the neuronatin family.

9544:DYNC1LI2
gene id: 9544:DYNC1LI2
uniprot id: A0A1D5RCQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9544:ATRX
gene id: 9544:ATRX
uniprot id: F6UJ05
uniprot id: F6ZEI1
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9544:GUCA2B
gene id: 9544:GUCA2B
uniprot id: A0A8J8YIH5
uniprot id: F6Y5V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9544:DDX52
gene id: 9544:DDX52
uniprot id: A0A5F8A253
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9544:CAMP
gene id: 9544:CAMP
uniprot id: Q9GLV5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After secretion onto the skin surface, the CAMP gene product is processed by a serine protease-dependent mechanism into multiple novel antimicrobial peptides distinct from and shorter than cathelicidin LL-37 (By similarity). These peptides show enhanced antimicrobial action, acquiring the ability to kill skin pathogens such as S.aureus, E.coli and C.albicans. These peptides have lost the ability to stimulate CXCL8/IL8 release from keratinocytes (By similarity). The peptides act synergistically, killing bacteria at lower concentrations when present together, and maintain activity at increased salt condition (By similarity).
messages: Antimicrobial peptide that is an integral component of the innate immune system (By similarity). Binds to bacterial lipopolysaccharides (LPS) (By similarity). Causes membrane permeabilization by forming transmembrane pores (in vitro) (By similarity). Causes lysis of E.coli (By similarity). Exhibits antimicrobial activity against Gram-negative bacteria such as P.aeruginosa, S.typhimurium, E.aerogenes, E.coli and P.syringae, Gram-positive bacteria such as L.monocytogenes, S.epidermidis, S.pyogenes and S.aureus, as well as vancomycin-resistant enterococci (in vitro) (By similarity). Exhibits antimicrobial activity against methicillin-resistant S.aureus, P.mirabilis, and C.albicans in low-salt media, but not in media containing 100 mM NaCl (in vitro) (By similarity). Forms chiral supramolecular assemblies with quinolone signal (PQS) molecules of P.aeruginosa, which may lead to interference of bacterial quorum signaling and perturbance of bacterial biofilm formation (By similarity). May form supramolecular fiber-like assemblies on bacterial membranes (By similarity). Induces cytokine and chemokine producation as well as TNF/TNFA and CSF2/GMCSF production in normal human keratinocytes (By similarity). Exhibits hemolytic activity against red blood cells (By similarity).
messages: Antimicrobial protein that is an integral component of the innate immune system (By similarity). Binds to bacterial lipopolysaccharides (LPS) (By similarity). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (By similarity). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (By similarity). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro) (By similarity).
messages: Belongs to the cathelicidin family.
messages: Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).
messages: Monomer, homodimer or homotrimer (in vitro) (By similarity). Oligomerizes as tetra- or hexamer in solution (in vitro) (By similarity).
messages: Proteolytically cleaved by proteinase PRTN3 into antibacterial peptide LL-37 (By similarity). Proteolytically cleaved by cathepsin CTSG and neutrophil elastase ELANE (By similarity).
messages: Residues 17-29 of LL-37 represent the active core of the antimicrobial peptide. Forms ribbon-like fibrils and exhibits antibacterial activity against Gram-positive M.luteus (By similarity). Also exhibits antibacterial activity against Gram-negative E.coli and P.fluorescens (By similarity).
messages: Resistant to proteolytic degradation in solution, and when bound to both zwitterionic (mimicking mammalian membranes) and negatively charged membranes (mimicking bacterial membranes).
messages: Secreted
messages: The cathelin-like domain (CLD), which is the propeptide part, does not seem to exhibit auto-inhibitory function, as it does not inhibit the antibacterial activity of antibacterial peptide LL-37.
messages: Undergoes conformational change in the presence of lipid A, transitioning from a random coil to an alpha-helical structure.
messages: Vesicle

9544:ANXA7
gene id: 9544:ANXA7
uniprot id: H9FTQ2
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9544:TAFA2
gene id: 9544:TAFA2
uniprot id: H9ENL3
names: Similarity
messages: Belongs to the TAFA family.

9544:DOLPP1
gene id: 9544:DOLPP1
uniprot id: A0A8J8YPV0
uniprot id: G7NFK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9544:PROX1
gene id: 9544:PROX1
uniprot id: A0A8J8XAF2
uniprot id: G7MEK6
names: Subcellular Location Annotation
messages: Nucleus

9544:SNX9
gene id: 9544:SNX9
uniprot id: A0A5F8ANR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9544:C10H20orf27
gene id: 9544:C10H20orf27
uniprot id: F7HNY8
uniprot id: G7N2V0
names: Similarity
messages: Belongs to the ADISSP family.

9544:CAND1
gene id: 9544:CAND1
uniprot id: A0A8J8YMU0
uniprot id: H9EMN0
names: Similarity
messages: Belongs to the CAND family.

9544:EARS2
gene id: 9544:EARS2
uniprot id: A0A5F8AHU2
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9544:OR6C4
gene id: 9544:OR6C4
uniprot id: F6S5B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9544:RNF182
gene id: 9544:RNF182
uniprot id: A0A8J8XTH4
uniprot id: F7HNS9
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9544:SULT1E1
gene id: 9544:SULT1E1
uniprot id: F6RUQ2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9544:ATP5ME
gene id: 9544:ATP5ME
uniprot id: H9FVS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9544:NAP1L1
gene id: 9544:NAP1L1
uniprot id: F7BMC8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:KIF11
gene id: 9544:KIF11
uniprot id: F7FKH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle pole

9544:FOXP2
gene id: 9544:FOXP2
uniprot id: A0A1I7Q461
uniprot id: Q8MJ97
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1 (By similarity). Interacts with FOXP1 (By similarity). Interacts with TBR1 (By similarity). Interacts with ZMYM2 (By similarity).
messages: Nucleus
messages: The leucine-zipper is required for dimerization and transcriptional repression.
messages: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels (By similarity).

9544:COPS7B
gene id: 9544:COPS7B
uniprot id: A0A8J8Y4J8
uniprot id: F6T991
uniprot id: F6UMP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9544:BCOR
gene id: 9544:BCOR
uniprot id: H9ER92
uniprot id: H9ERA3
uniprot id: H9ERD1
names: Similarity
messages: Belongs to the BCOR family.

9544:CDC25A
gene id: 9544:CDC25A
uniprot id: A0A1D5QME8
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9544:FAM126A
gene id: 9544:FAM126A
uniprot id: H9ZEG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9544:TRIML2
gene id: 9544:TRIML2
uniprot id: F7ED52
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:TBL1Y
gene id: 9544:TBL1Y
uniprot id: A0A1D5QQ61
uniprot id: B8YE10
names: Similarity
messages: Belongs to the WD repeat EBI family.

9544:POMC
gene id: 9544:POMC
uniprot id: A0A5F8AUI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Endogenous orexigenic opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

9544:FAAH2
gene id: 9544:FAAH2
uniprot id: A0A8J8Y2W9
uniprot id: F6VCV8
names: Similarity
messages: Belongs to the amidase family.

9544:SLC43A2
gene id: 9544:SLC43A2
uniprot id: H9Z574
names: Subcellular Location Annotation
messages: Membrane

9544:FXR1
gene id: 9544:FXR1
uniprot id: A0A5K1U2G4
uniprot id: H9EN88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Nucleus envelope
messages: Postsynapse
messages: Synapse
messages: dendritic spine

9544:C18H18orf25
gene id: 9544:C18H18orf25
uniprot id: F7AF08
uniprot id: H9YY65
names: Subcellular Location Annotation
messages: Nucleus

9544:KDM3B
gene id: 9544:KDM3B
uniprot id: I0FSK5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9544:PPP2R2A
gene id: 9544:PPP2R2A
uniprot id: H9FWK6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9544:SMARCAD1
gene id: 9544:SMARCAD1
uniprot id: H9FXC5
names: Subcellular Location Annotation
messages: Chromosome

9544:AK8
gene id: 9544:AK8
uniprot id: G7NFH2
names: Similarity
messages: Belongs to the adenylate kinase family.

9544:MSH6
gene id: 9544:MSH6
uniprot id: F6UF63
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

9544:OSTC
gene id: 9544:OSTC
uniprot id: H9FXX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9544:OR52M1
gene id: 9544:OR52M1
uniprot id: A0A5F7ZEU6
names: Subcellular Location Annotation
messages: Membrane

9544:SLC25A17
gene id: 9544:SLC25A17
uniprot id: A0A1D5R0D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:GKAP1
gene id: 9544:GKAP1
uniprot id: F7ASQ8
uniprot id: F7AST5
names: Similarity
messages: Belongs to the GKAP1 family.

9544:COX11
gene id: 9544:COX11
uniprot id: A0A8J8XE01
uniprot id: G7NHP1
uniprot id: Q4G3Z4
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

9544:AGPAT2
gene id: 9544:AGPAT2
uniprot id: H9Z384
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9544:PIGN
gene id: 9544:PIGN
uniprot id: A0A5F7ZMD8
uniprot id: A0A5F8A9N2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:SGTB
gene id: 9544:SGTB
uniprot id: A0A8J8XVG6
uniprot id: G7MU68
names: Similarity
messages: Belongs to the SGT family.

9544:PRR15
gene id: 9544:PRR15
uniprot id: A0A8J8Y9I4
uniprot id: F7HA41
names: Similarity
messages: Belongs to the PRR15 family.

9544:GGA3
gene id: 9544:GGA3
uniprot id: F7DH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9544:MSH4
gene id: 9544:MSH4
uniprot id: F6TF84
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9544:IGFBP3
gene id: 9544:IGFBP3
uniprot id: I0FH47
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:PSMB7
gene id: 9544:PSMB7
uniprot id: A0A8J8XZU7
uniprot id: F7E9M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9544:RPL24
gene id: 9544:RPL24
uniprot id: A0A8J8YIX2
uniprot id: G7MK26
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9544:GRAMD1B
gene id: 9544:GRAMD1B
uniprot id: A0A1D5Q4J4
uniprot id: A0A1D5QTT7
uniprot id: H9FXM0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CD209
gene id: 9544:CD209
uniprot id: Q95J96
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer. Interacts with C1QBP; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex. Interacts with ICAM2 and ICAM3 by binding to mannose-like carbohydrates. Interacts (via C-type lectin domain) with CEACAM1 (via Lewis X moieties); this interaction is regulated by the glycosylation pattern of CEACAM1 on cell types and regulates contact between dendritic cells and neutrophils.
messages: In vitro, is a receptor for HIV-1, HIV-2 and SIV and transmits viruses to permissive T-cells.
messages: Membrane
messages: On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells (By similarity).
messages: Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity).

9544:LOC719262
gene id: 9544:LOC719262
uniprot id: A0A8J8YFI3
uniprot id: G7NLR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:NR3C1
gene id: 9544:NR3C1
uniprot id: H9FTF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

9544:ANXA11
gene id: 9544:ANXA11
uniprot id: H9FTQ4
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9544:LAMTOR3
gene id: 9544:LAMTOR3
uniprot id: A0A8J8YMA1
uniprot id: G7MTI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9544:NAA30
gene id: 9544:NAA30
uniprot id: F6UYE1
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

9544:HMGN3
gene id: 9544:HMGN3
uniprot id: A0A1D5QS05
uniprot id: F7FVE3
uniprot id: H9G1X1
uniprot id: H9ZFF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9544:ADGRL3
gene id: 9544:ADGRL3
uniprot id: F7HQJ6
names: Subcellular Location Annotation
messages: Membrane

9544:MRE11
gene id: 9544:MRE11
uniprot id: A0A5K1UX03
uniprot id: H9Z952
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9544:NRF1
gene id: 9544:NRF1
uniprot id: H9FUZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9544:MAP2K4
gene id: 9544:MAP2K4
uniprot id: A0A1D5QAU9
uniprot id: F7FU91
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:EYA2
gene id: 9544:EYA2
uniprot id: F7FR55
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9544:LOC705611
gene id: 9544:LOC705611
uniprot id: F7D035
names: Similarity
messages: Belongs to the SPIN/STSY family.

9544:ALG13
gene id: 9544:ALG13
uniprot id: A0A5F8ASN1
uniprot id: A0A8J8XWU6
uniprot id: H9YV14
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

9544:KATNAL1
gene id: 9544:KATNAL1
uniprot id: F6Y7A7
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9544:MMP28
gene id: 9544:MMP28
uniprot id: A0A1D5Q565
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9544:SLC14A2
gene id: 9544:SLC14A2
uniprot id: F6XQB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9544:LOC106993227
gene id: 9544:LOC106993227
uniprot id: A0A5F7ZCF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9544:RAP2B
gene id: 9544:RAP2B
uniprot id: A0A8J8YGZ1
uniprot id: F7AWM6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9544:FXYD1
gene id: 9544:FXYD1
uniprot id: I0FIV7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the FXYD family.
messages: Cell membrane
messages: Membrane
messages: T-tubule
messages: caveola
messages: sarcolemma

9544:UCK1
gene id: 9544:UCK1
uniprot id: A0A1D5R0F2
names: Similarity
messages: Belongs to the uridine kinase family.

9544:GTF2H3
gene id: 9544:GTF2H3
uniprot id: H9ENW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9544:LOC695847
gene id: 9544:LOC695847
uniprot id: F7GZC5
names: Subcellular Location Annotation
messages: Nucleus

9544:PTPRN
gene id: 9544:PTPRN
uniprot id: I2CY08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9544:ELP6
gene id: 9544:ELP6
uniprot id: A0A5F7ZIT4
uniprot id: H9EXR4
names: Similarity
messages: Belongs to the ELP6 family.

9544:S100B
gene id: 9544:S100B
uniprot id: A0A8J8YKQ7
uniprot id: F7ANQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9544:TFDP3
gene id: 9544:TFDP3
uniprot id: A0A8J8XSQ2
uniprot id: F7HDM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9544:TMEM63A
gene id: 9544:TMEM63A
uniprot id: A0A1D5QTM5
uniprot id: A0A5F8A9X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9544:UGT2B9*2
gene id: 9544:UGT2B9*2
uniprot id: Q9GLE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9544:ST7L
gene id: 9544:ST7L
uniprot id: A0A5F7ZS33
uniprot id: F7CW28
uniprot id: F7CW41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9544:C19H19orf66
gene id: 9544:C19H19orf66
uniprot id: H9FWR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Cytoplasm
messages: Nucleus

9544:UBE2B
gene id: 9544:UBE2B
uniprot id: A0A8J8Y4G8
uniprot id: H9YWP0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:FGF12
gene id: 9544:FGF12
uniprot id: G7MK95
uniprot id: H9FRD2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:RPL10A
gene id: 9544:RPL10A
uniprot id: F7AMR7
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9544:EPHA4
gene id: 9544:EPHA4
uniprot id: A0A8J8XFI3
uniprot id: G7N911
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9544:BCAS2
gene id: 9544:BCAS2
uniprot id: I2CYF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

9544:COL4A2
gene id: 9544:COL4A2
uniprot id: A0A5K1VIA9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9544:XRN1
gene id: 9544:XRN1
uniprot id: F6WU61
uniprot id: F7APA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9544:LMOD3
gene id: 9544:LMOD3
uniprot id: F7FCR8
names: Subcellular Location Annotation
messages: cytoskeleton

9544:TMEM11
gene id: 9544:TMEM11
uniprot id: A0A8J8XZM4
uniprot id: F6UDS1
uniprot id: F7HL31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Plays a role in mitochondrial morphogenesis.

9544:BOP1
gene id: 9544:BOP1
uniprot id: F7GBS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9544:CASD1
gene id: 9544:CASD1
uniprot id: F7G2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

9544:CBX3
gene id: 9544:CBX3
uniprot id: A0A1D5R706
uniprot id: H9FPI2
names: Subcellular Location Annotation
messages: Nucleus

9544:ARL11
gene id: 9544:ARL11
uniprot id: G7NK52
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9544:PRKCD
gene id: 9544:PRKCD
uniprot id: H9EU39
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

9544:ZC3H12C
gene id: 9544:ZC3H12C
uniprot id: G7NBZ6
names: Similarity
messages: Belongs to the ZC3H12 family.

9544:THG1L
gene id: 9544:THG1L
uniprot id: G7MVS0
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

9544:TSEN54
gene id: 9544:TSEN54
uniprot id: H9EWS1
names: Similarity
messages: Belongs to the SEN54 family.

9544:LOC717993
gene id: 9544:LOC717993
uniprot id: G7MDQ1
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9544:PIAS3
gene id: 9544:PIAS3
uniprot id: H9FNP4
names: Similarity
messages: Belongs to the PIAS family.

9544:KRTAP8-1
gene id: 9544:KRTAP8-1
uniprot id: F6WWY9
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9544:CD3E
gene id: 9544:CD3E
uniprot id: A0A8J8XSI9
uniprot id: G7NCB9
names: Subcellular Location Annotation
messages: Membrane

9544:LOC707363
gene id: 9544:LOC707363
uniprot id: A0A8J8YLC8
uniprot id: F7FL31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:CDC42EP2
gene id: 9544:CDC42EP2
uniprot id: A0A8J8XHU7
uniprot id: F7DGL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9544:JAK2
gene id: 9544:JAK2
uniprot id: A0A5F8ATC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Cytoplasm
messages: Endomembrane system
messages: Nucleus

9544:GRIK2
gene id: 9544:GRIK2
uniprot id: H9EM65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:CASKIN2
gene id: 9544:CASKIN2
uniprot id: A0A5F8A9P6
names: Subcellular Location Annotation
messages: Cytoplasm

9544:SMS
gene id: 9544:SMS
uniprot id: H9FYS7
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9544:MALSU1
gene id: 9544:MALSU1
uniprot id: H9Z517
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9544:FZD2
gene id: 9544:FZD2
uniprot id: F7GPB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:PRR5
gene id: 9544:PRR5
uniprot id: F7GAR1
uniprot id: I0FT82
names: Similarity
messages: Belongs to the PROTOR family.

9544:MAPKAPK3
gene id: 9544:MAPKAPK3
uniprot id: A0A8J8XLX9
uniprot id: F7BFL2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:AJAP1
gene id: 9544:AJAP1
uniprot id: F7ERB1
names: Subcellular Location Annotation
messages: Membrane

9544:LOC100430373
gene id: 9544:LOC100430373
uniprot id: F7CF53
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9544:CHST14
gene id: 9544:CHST14
uniprot id: A0A5F8A6I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:MIEF1
gene id: 9544:MIEF1
uniprot id: F7GFQ1
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9544:ILF3
gene id: 9544:ILF3
uniprot id: F7FLD2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:HAL
gene id: 9544:HAL
uniprot id: F7H197
names: Similarity
messages: Belongs to the PAL/histidase family.

9544:MED13L
gene id: 9544:MED13L
uniprot id: F7FWX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:DNAJA2
gene id: 9544:DNAJA2
uniprot id: A0A8J8XAS6
uniprot id: G7NP88
names: Subcellular Location Annotation
messages: Membrane

9544:PDGFRB
gene id: 9544:PDGFRB
uniprot id: F7BTH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.
messages: Lysosome lumen
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
messages: Vesicle

9544:LAMTOR1
gene id: 9544:LAMTOR1
uniprot id: A0A8J8YAD4
uniprot id: H9ELW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9544:ITGB5
gene id: 9544:ITGB5
uniprot id: H9ERG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9544:DLAT
gene id: 9544:DLAT
uniprot id: F6WRQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9544:ARL4D
gene id: 9544:ARL4D
uniprot id: A0A8J8XSY6
uniprot id: F6URI0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9544:ARHGEF6
gene id: 9544:ARHGEF6
uniprot id: A0A5F7ZZM7
uniprot id: A0A5F8ARJ3
uniprot id: A0A8J8XW37
uniprot id: G7NRP9
names: Subcellular Location Annotation
messages: lamellipodium

9544:ATP2B1
gene id: 9544:ATP2B1
uniprot id: F7E3S4
uniprot id: H9Z9D5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:MTM1
gene id: 9544:MTM1
uniprot id: F6Z4P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9544:PPP4C
gene id: 9544:PPP4C
uniprot id: A0A8J8XL54
uniprot id: F6SRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9544:COMTD1
gene id: 9544:COMTD1
uniprot id: H9Z547
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9544:ITPR3
gene id: 9544:ITPR3
uniprot id: G7MRR0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9544:SURF6
gene id: 9544:SURF6
uniprot id: G7NFG2
names: Similarity
messages: Belongs to the SURF6 family.

9544:ELAVL4
gene id: 9544:ELAVL4
uniprot id: A0A1D5RHY3
uniprot id: A0A8J8XDK8
uniprot id: F6T409
uniprot id: F6T420
uniprot id: G7MGY7
uniprot id: H9FQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9544:CHST2
gene id: 9544:CHST2
uniprot id: F7H292
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9544:SLC35D2
gene id: 9544:SLC35D2
uniprot id: F7HLK1
names: Subcellular Location Annotation
messages: Membrane

9544:SH3RF2
gene id: 9544:SH3RF2
uniprot id: F7GZK9
names: Similarity
messages: Belongs to the SH3RF family.

9544:CYP3A43
gene id: 9544:CYP3A43
uniprot id: B1NL88
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:SLC34A3
gene id: 9544:SLC34A3
uniprot id: A0A5F8AJ48
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9544:AMHR2
gene id: 9544:AMHR2
uniprot id: A0A8J8XFT0
uniprot id: F7GDJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

9544:RPL17
gene id: 9544:RPL17
uniprot id: F7CL39
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9544:GC
gene id: 9544:GC
uniprot id: G7MT44
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9544:GNG10
gene id: 9544:GNG10
uniprot id: A0A1D5RGW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:ATIC
gene id: 9544:ATIC
uniprot id: G7N8U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

9544:GLDN
gene id: 9544:GLDN
uniprot id: G7MXB1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ACKR3
gene id: 9544:ACKR3
uniprot id: A0A8J8YNH9
uniprot id: F7GTL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:MOB3A
gene id: 9544:MOB3A
uniprot id: A0A8J8Y516
uniprot id: G7NL64
names: Similarity
messages: Belongs to the MOB1/phocein family.

9544:SLC30A9
gene id: 9544:SLC30A9
uniprot id: H9FNR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

9544:STOML1
gene id: 9544:STOML1
uniprot id: A0A1D5Q0D5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9544:GTF2H1
gene id: 9544:GTF2H1
uniprot id: H9FTI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9544:AR
gene id: 9544:AR
uniprot id: Q6QT55
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1 and RREB1. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with MACROD1 (via macro domain) (By similarity). Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 (via coiled coil domain). Interacts (via ligand-binding domain) with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK and NCOA3. Interacts with CRY1. Interacts with CCAR1 and GATA2. Interacts with ZNF318. Interacts with BUD31. Interacts with ARID4A. Interacts with ARID4B. Interacts (via NR LBD domain) with ZBTB7A; the interaction is direct and androgen-dependent (By similarity). Interacts with NCOR1 (By similarity). Interacts with NCOR2 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain (By similarity).
messages: Cytoplasm
messages: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
messages: Nucleus
messages: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation (By similarity).
messages: Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-510 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity). Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity. Phosphorylation at Ser-65 by CDK9 regulates AR promoter selectivity and cell growth (By similarity).
messages: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
messages: Sumoylated on Lys-371 (major) and Lys-496 (By similarity). Ubiquitinated. Deubiquitinated by USP26 (By similarity). 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity (By similarity).
messages: Transcriptional activity is enhanced by binding to RANBP9.

9544:HS6ST2
gene id: 9544:HS6ST2
uniprot id: F6Z463
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9544:LOC100426235
gene id: 9544:LOC100426235
uniprot id: A0A5F8AJW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:COX6C
gene id: 9544:COX6C
uniprot id: A0A8J8Y0R1
uniprot id: F7HLV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9544:FAXC
gene id: 9544:FAXC
uniprot id: F6WV55
names: Similarity
messages: Belongs to the FAX family.

9544:SEC61A1
gene id: 9544:SEC61A1
uniprot id: H9EML7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ZDHHC17
gene id: 9544:ZDHHC17
uniprot id: H9EPX7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:RPL38
gene id: 9544:RPL38
uniprot id: G7NGL5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9544:SEPTIN11
gene id: 9544:SEPTIN11
uniprot id: A0A1D5QBP6
uniprot id: A0A1D5QDX5
uniprot id: A0A5F7ZQN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9544:MRGPRX2
gene id: 9544:MRGPRX2
uniprot id: Q4QXU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
messages: Cell membrane
messages: Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction.

9544:CRYGC
gene id: 9544:CRYGC
uniprot id: A3RLD8
uniprot id: G7N8S3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

9544:VARS
gene id: 9544:VARS
uniprot id: A0A8J8XAC5
uniprot id: G7MRK4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:HTRA1
gene id: 9544:HTRA1
uniprot id: H9FX91
names: Similarity
messages: Belongs to the peptidase S1C family.

9544:DCLK2
gene id: 9544:DCLK2
uniprot id: H9ES18
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9544:DCLRE1C
gene id: 9544:DCLRE1C
uniprot id: E5FGG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9544:PSMA6
gene id: 9544:PSMA6
uniprot id: A0A8J8YIK0
uniprot id: H9YZY1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9544:SEPTIN10
gene id: 9544:SEPTIN10
uniprot id: A0A1D5R632
uniprot id: A0A1D5R7D0
uniprot id: H9ES95
uniprot id: H9YUU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9544:RING1
gene id: 9544:RING1
uniprot id: Q8WMN5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of chromatin-associated Polycomb (PcG) complexes. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2. Interacts with PHC2, PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with BMI1 (By similarity). Interacts with MN1 (By similarity).
messages: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity).
messages: Nucleus speckle

9544:DPH2
gene id: 9544:DPH2
uniprot id: A0A8J8YJK1
uniprot id: G7MGM0
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9544:ABCC8
gene id: 9544:ABCC8
uniprot id: F7HFY4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

9544:AADACL4
gene id: 9544:AADACL4
uniprot id: A0A5K1VJB0
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9544:GBX2
gene id: 9544:GBX2
uniprot id: F6WW58
names: Subcellular Location Annotation
messages: Nucleus

9544:MEF2C
gene id: 9544:MEF2C
uniprot id: A0A8J8Y518
uniprot id: G7MV83
uniprot id: H9FUJ7
uniprot id: H9Z924
uniprot id: H9Z925
names: Subcellular Location Annotation
messages: Nucleus

9544:MRRF
gene id: 9544:MRRF
uniprot id: F6S9C1
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9544:PIGS
gene id: 9544:PIGS
uniprot id: F6V7D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:EFTUD2
gene id: 9544:EFTUD2
uniprot id: A0A1D5R732
uniprot id: A0A8J8XIA2
uniprot id: G7NIZ0
names: Subcellular Location Annotation
messages: Nucleus

9544:NUP107
gene id: 9544:NUP107
uniprot id: F6PUD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

9544:TMIGD3
gene id: 9544:TMIGD3
uniprot id: F7ENK5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:UQCC3
gene id: 9544:UQCC3
uniprot id: A0A8J8XRZ3
uniprot id: F6SE25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9544:GREM2
gene id: 9544:GREM2
uniprot id: A0A8J8YPE8
uniprot id: F7HBP1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:LIN54
gene id: 9544:LIN54
uniprot id: A0A8J8YCK8
uniprot id: G7MSX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9544:VRK1
gene id: 9544:VRK1
uniprot id: H9ZD73
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:CDH20
gene id: 9544:CDH20
uniprot id: G7NKT4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:STK11
gene id: 9544:STK11
uniprot id: A0A5F7ZZ39
uniprot id: A0A8J8YCW3
uniprot id: H9ETP1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

9544:PDK4
gene id: 9544:PDK4
uniprot id: A0A8J8XI95
uniprot id: F7FDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9544:MTX2
gene id: 9544:MTX2
uniprot id: A0A1D5R816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9544:KRT1
gene id: 9544:KRT1
uniprot id: A0A8J8YEW4
uniprot id: F7B786
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9544:CSK
gene id: 9544:CSK
uniprot id: F7GRP2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9544:ADK
gene id: 9544:ADK
uniprot id: F6Z1M1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9544:SBF1
gene id: 9544:SBF1
uniprot id: H9FY86
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9544:ZNF263
gene id: 9544:ZNF263
uniprot id: H9Z417
names: Subcellular Location Annotation
messages: Nucleus

9544:LOC107000957
gene id: 9544:LOC107000957
uniprot id: F6VGX3
names: Similarity
messages: Belongs to the LCE family.

9544:N6AMT1
gene id: 9544:N6AMT1
uniprot id: A0A8J8YK96
uniprot id: G7MN56
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

9544:TBX3
gene id: 9544:TBX3
uniprot id: A0A8J8Y5K9
uniprot id: F6WW74
uniprot id: G7N5Q8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:GPR87
gene id: 9544:GPR87
uniprot id: A0A1D5R3A6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:GPR83
gene id: 9544:GPR83
uniprot id: A0A1D5R7E2
uniprot id: A0A8J8XBF8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:LTB
gene id: 9544:LTB
uniprot id: Q5TM22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface (By similarity).
messages: Heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.
messages: Membrane

9544:CELF2
gene id: 9544:CELF2
uniprot id: A0A1D5QPJ8
uniprot id: H9FNW3
uniprot id: H9FNW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9544:SCP2
gene id: 9544:SCP2
uniprot id: G7MH13
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion

9544:ARAP1
gene id: 9544:ARAP1
uniprot id: F6TKN2
names: Subcellular Location Annotation
messages: Cytoplasm

9544:ZNRD1
gene id: 9544:ZNRD1
uniprot id: F7H8M1
uniprot id: Q5TM50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

9544:ST8SIA5
gene id: 9544:ST8SIA5
uniprot id: A0A5K1U5B5
uniprot id: A0A8J8XMS2
uniprot id: A2VBC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:BICD2
gene id: 9544:BICD2
uniprot id: F6QN54
uniprot id: H9FRX7
names: Similarity
messages: Belongs to the BicD family.

9544:HIST2H2AC
gene id: 9544:HIST2H2AC
uniprot id: A0A8J8XTY8
uniprot id: F7BRD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:LIPH
gene id: 9544:LIPH
uniprot id: I0FPU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9544:TMEM192
gene id: 9544:TMEM192
uniprot id: A0A8J8Y777
uniprot id: G7MS96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9544:TMEM170B
gene id: 9544:TMEM170B
uniprot id: A0A8J8YBL8
uniprot id: F7HN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9544:METTL3
gene id: 9544:METTL3
uniprot id: A0A8J8YGJ7
uniprot id: G7MWT2
names: Similarity
messages: Belongs to the MT-A70-like family.

9544:BCL2L1
gene id: 9544:BCL2L1
uniprot id: A0A8J8XVY1
uniprot id: F6UKR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9544:ANK2
gene id: 9544:ANK2
uniprot id: I2CXZ5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9544:SERPINB1
gene id: 9544:SERPINB1
uniprot id: A0A1D5RIS2
uniprot id: A0A8J8YAW7
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9544:MMP13
gene id: 9544:MMP13
uniprot id: F6YQ28
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9544:ACTRT3
gene id: 9544:ACTRT3
uniprot id: F6Q5K2
names: Similarity
messages: Belongs to the actin family.

9544:NAP1L3
gene id: 9544:NAP1L3
uniprot id: F7DX32
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:MAL
gene id: 9544:MAL
uniprot id: A0A8J8XHP9
uniprot id: G7NAM1
names: Subcellular Location Annotation
messages: Membrane

9544:SEPTIN6
gene id: 9544:SEPTIN6
uniprot id: A0A1D5R3V4
uniprot id: F6TJ87
uniprot id: H9FRS6
uniprot id: H9YXW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9544:RAB3C
gene id: 9544:RAB3C
uniprot id: A0A5F7ZAL7
uniprot id: A0A8J8Y6H1
uniprot id: F7CYU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9544:FGF9
gene id: 9544:FGF9
uniprot id: A0A8J8XW81
uniprot id: F6YCT2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:TPD52L1
gene id: 9544:TPD52L1
uniprot id: A0A5F7ZBT5
uniprot id: A0A5F8APT0
uniprot id: A0A8J8YGR1
uniprot id: G7MQK9
uniprot id: I0FMV0
uniprot id: I0FMV2
names: Similarity
messages: Belongs to the TPD52 family.

9544:INTS3
gene id: 9544:INTS3
uniprot id: H9FYM8
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9544:ACYP1
gene id: 9544:ACYP1
uniprot id: H9EWH1
names: Similarity
messages: Belongs to the acylphosphatase family.

9544:SUSD6
gene id: 9544:SUSD6
uniprot id: A0A8J8XM14
uniprot id: G7MYI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TMEM225
gene id: 9544:TMEM225
uniprot id: A0A8J8XPK7
uniprot id: F6Y415
names: Subcellular Location Annotation
messages: Membrane

9544:ADGRA3
gene id: 9544:ADGRA3
uniprot id: A0A5F7ZLE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9544:CABIN1
gene id: 9544:CABIN1
uniprot id: H9Z748
names: Subcellular Location Annotation
messages: Nucleus

9544:NOP2
gene id: 9544:NOP2
uniprot id: A0A1D5QF41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

9544:ASF1B
gene id: 9544:ASF1B
uniprot id: I0FMW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9544:DEFA6
gene id: 9544:DEFA6
uniprot id: A0A8J8Y0I9
uniprot id: F7DMC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9544:DPM2
gene id: 9544:DPM2
uniprot id: H9EXG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9544:CHST9
gene id: 9544:CHST9
uniprot id: A0A8J8XKX8
uniprot id: G7NKI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:IL12B
gene id: 9544:IL12B
uniprot id: P48095
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Secreted

9544:MEOX1
gene id: 9544:MEOX1
uniprot id: F6PKE6
names: Subcellular Location Annotation
messages: Nucleus

9544:PPM1B
gene id: 9544:PPM1B
uniprot id: A0A8J8XN57
uniprot id: F6XPC8
uniprot id: H9EM08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9544:IZUMO2
gene id: 9544:IZUMO2
uniprot id: F7HLF2
names: Similarity
messages: Belongs to the Izumo family.

9544:MCOLN3
gene id: 9544:MCOLN3
uniprot id: A0A8J8YNR3
uniprot id: F7GDU9
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9544:SLC44A3
gene id: 9544:SLC44A3
uniprot id: F7HE00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9544:ZNF280B
gene id: 9544:ZNF280B
uniprot id: A0A8J8YL85
uniprot id: F7H7I5
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9544:SSR2
gene id: 9544:SSR2
uniprot id: A0A5F8A7M9
uniprot id: A0A8J8XRM8
uniprot id: G7MDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9544:SPATA18
gene id: 9544:SPATA18
uniprot id: F6YKE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

9544:VEGFB
gene id: 9544:VEGFB
uniprot id: F6RJK6
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9544:LOC694859
gene id: 9544:LOC694859
uniprot id: A0A5F7ZTG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9544:DGKA
gene id: 9544:DGKA
uniprot id: A0A8J8XWB0
uniprot id: F6ZHF9
uniprot id: G7N7A5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Monomer.

9544:MCM8
gene id: 9544:MCM8
uniprot id: F6RN32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9544:DENND5A
gene id: 9544:DENND5A
uniprot id: A0A5F8AQ23
uniprot id: F7HB53
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TMEM35B
gene id: 9544:TMEM35B
uniprot id: A0A8J8Y2F2
uniprot id: F7ATL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9544:DNAH1
gene id: 9544:DNAH1
uniprot id: F7AZV1
names: Similarity
messages: Belongs to the dynein heavy chain family.

9544:PDE3B
gene id: 9544:PDE3B
uniprot id: F6RK06
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:TSNAX
gene id: 9544:TSNAX
uniprot id: H9FZ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9544:SLC12A3
gene id: 9544:SLC12A3
uniprot id: F6QQS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9544:ST7
gene id: 9544:ST7
uniprot id: A0A1D5QPA9
uniprot id: F7E749
uniprot id: H9EN24
uniprot id: H9FZX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9544:GAB3
gene id: 9544:GAB3
uniprot id: F6WAT4
names: Similarity
messages: Belongs to the GAB family.

9544:PDYN
gene id: 9544:PDYN
uniprot id: A0A8J8YRB7
uniprot id: F6R267
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
messages: Secreted

9544:ACVR1B
gene id: 9544:ACVR1B
uniprot id: I2CYX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9544:LOC701574
gene id: 9544:LOC701574
uniprot id: A0A1D5QW91
uniprot id: A0A8J8YRZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:MAGOH
gene id: 9544:MAGOH
uniprot id: A0A8J8Y1M5
uniprot id: H9FUG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9544:GRB2
gene id: 9544:GRB2
uniprot id: A0A8J8YCF4
uniprot id: G7NGP6
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9544:SLC17A1
gene id: 9544:SLC17A1
uniprot id: G7MQV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

9544:EBF2
gene id: 9544:EBF2
uniprot id: A0A8J8YRL5
uniprot id: F6W1L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9544:DUSP3
gene id: 9544:DUSP3
uniprot id: F7C5I2
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9544:CTSC
gene id: 9544:CTSC
uniprot id: Q3YAN9
names: Similarity
messages: Belongs to the peptidase C1 family.

9544:C20H16orf70
gene id: 9544:C20H16orf70
uniprot id: A0A8J8XCQ3
uniprot id: F7EFR6
names: Similarity
messages: Belongs to the PHAF1 family.

9544:ATP5MC3
gene id: 9544:ATP5MC3
uniprot id: A0A8J8XHG3
uniprot id: F6ZG64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9544:ABCG2
gene id: 9544:ABCG2
uniprot id: G8F1F3
uniprot id: H9EWM4
uniprot id: I2CY94
uniprot id: Q5MB13
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the riboflavin and biotin vitamins into milk. Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain. It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (By similarity). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus. May play a role in early stem cell self-renewal by blocking differentiation (PubMed:15516692).
messages: Cell membrane
messages: Homodimer; disulfide-linked. The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers.
messages: Membrane
messages: Mitochondrion membrane
messages: N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional.
messages: Phosphorylated. Phosphorylation may regulate the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.
messages: The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.

9544:LANCL3
gene id: 9544:LANCL3
uniprot id: A0A1D5QWE1
names: Similarity
messages: Belongs to the LanC-like protein family.

9544:PAN2
gene id: 9544:PAN2
uniprot id: I0FWV6
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9544:SAMD4A
gene id: 9544:SAMD4A
uniprot id: A0A1D5RBE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9544:C6H5orf30
gene id: 9544:C6H5orf30
uniprot id: A0A8J8XGM7
uniprot id: F6Z3P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9544:LOC107000401
gene id: 9544:LOC107000401
uniprot id: F7GZH5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9544:SERPINF1
gene id: 9544:SERPINF1
uniprot id: F6ZGR2
names: Similarity
messages: Belongs to the serpin family.

9544:ARFGEF2
gene id: 9544:ARFGEF2
uniprot id: F7AUW7
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9544:PSMB6
gene id: 9544:PSMB6
uniprot id: G7NI33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9544:MRPL41
gene id: 9544:MRPL41
uniprot id: H9ZCJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9544:ALG11
gene id: 9544:ALG11
uniprot id: H9FUM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9544:HK1
gene id: 9544:HK1
uniprot id: H9FTP9
names: Similarity
messages: Belongs to the hexokinase family.

9544:NSUN5
gene id: 9544:NSUN5
uniprot id: F7G8Y6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9544:MAP4K2
gene id: 9544:MAP4K2
uniprot id: H9ETH7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9544:CYP27A1
gene id: 9544:CYP27A1
uniprot id: A0A8J8XB98
uniprot id: F7HD06
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:HBP1
gene id: 9544:HBP1
uniprot id: F6Q4Y7
uniprot id: I0FQU7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9544:GABRP
gene id: 9544:GABRP
uniprot id: G7MVV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:DTNA
gene id: 9544:DTNA
uniprot id: F7ELC4
uniprot id: I0FPQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9544:SLC25A10
gene id: 9544:SLC25A10
uniprot id: I0FK24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:TMEM88
gene id: 9544:TMEM88
uniprot id: A0A8J8YJ17
uniprot id: F7GYT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9544:DUSP7
gene id: 9544:DUSP7
uniprot id: F7GK32
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9544:NEK7
gene id: 9544:NEK7
uniprot id: A0A1D5QLT8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:STMN4
gene id: 9544:STMN4
uniprot id: A0A1D5Q8D7
uniprot id: F6ZYT6
names: Similarity
messages: Belongs to the stathmin family.

9544:CALR3
gene id: 9544:CALR3
uniprot id: A0A8J8XT33
uniprot id: G7NMP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9544:JPT1
gene id: 9544:JPT1
uniprot id: H9EQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9544:NOSIP
gene id: 9544:NOSIP
uniprot id: A0A8J8XY85
uniprot id: H9ETT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

9544:PKN1
gene id: 9544:PKN1
uniprot id: H9FX40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9544:TMEM106C
gene id: 9544:TMEM106C
uniprot id: A0A8J8XKR1
uniprot id: H9FZN1
names: Similarity
messages: Belongs to the TMEM106 family.

9544:DKK1
gene id: 9544:DKK1
uniprot id: A0A8J8YG19
uniprot id: F7G3K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9544:FXYD5
gene id: 9544:FXYD5
uniprot id: A0A8J8XAK0
uniprot id: G7NM42
names: Similarity
messages: Belongs to the FXYD family.

9544:CDK5
gene id: 9544:CDK5
uniprot id: H9EQ04
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:CTSD
gene id: 9544:CTSD
uniprot id: A0A5F8ABN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

9544:TMEM225B
gene id: 9544:TMEM225B
uniprot id: A0A5F7Z772
names: Subcellular Location Annotation
messages: Membrane

9544:GNAZ
gene id: 9544:GNAZ
uniprot id: A0A8J8XGI8
uniprot id: F7GJC8
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:LPCAT2
gene id: 9544:LPCAT2
uniprot id: A0A1D5Q5F4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9544:RRP8
gene id: 9544:RRP8
uniprot id: A0A8J8XMA3
uniprot id: F7C3H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: nucleolus

9544:CELF1
gene id: 9544:CELF1
uniprot id: F6SSD3
uniprot id: F7HGX2
uniprot id: H9EM84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9544:OR4N2
gene id: 9544:OR4N2
uniprot id: F6U4W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CETN1
gene id: 9544:CETN1
uniprot id: G7NKF7
names: Similarity
messages: Belongs to the centrin family.

9544:HHIP
gene id: 9544:HHIP
uniprot id: A0A5F8ADQ8
uniprot id: F7HQP4
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:MED10
gene id: 9544:MED10
uniprot id: A0A8J8XEA1
uniprot id: F6Z795
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:KCNJ14
gene id: 9544:KCNJ14
uniprot id: F7GGT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:NDRG2
gene id: 9544:NDRG2
uniprot id: H9YYM8
uniprot id: I2CY02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

9544:CASK
gene id: 9544:CASK
uniprot id: A0A1D5QVF6
uniprot id: A0A1D5R5P2
uniprot id: H9EPC3
names: Similarity
messages: Belongs to the MAGUK family.

9544:HMGA1
gene id: 9544:HMGA1
uniprot id: H9Z8B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9544:SENP1
gene id: 9544:SENP1
uniprot id: H9FTJ4
names: Similarity
messages: Belongs to the peptidase C48 family.

9544:FBN1
gene id: 9544:FBN1
uniprot id: F6YVP3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:ARHGDIB
gene id: 9544:ARHGDIB
uniprot id: A0A8J8XQ13
uniprot id: G7N6F2
names: Similarity
messages: Belongs to the Rho GDI family.

9544:PSKH1
gene id: 9544:PSKH1
uniprot id: A0A8J8Y0K8
uniprot id: F7HN09
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:PRND
gene id: 9544:PRND
uniprot id: A0A8J8Y3I9
uniprot id: A2BDH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9544:GRIA4
gene id: 9544:GRIA4
uniprot id: A0A5F8A4A5
uniprot id: F7AGS3
uniprot id: G7NBS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:FLT1
gene id: 9544:FLT1
uniprot id: G7NJV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9544:AKR1D1
gene id: 9544:AKR1D1
uniprot id: A0A1D5RJH1
uniprot id: A0A8J8YCD0
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9544:POLR2I
gene id: 9544:POLR2I
uniprot id: A0A8J8XPJ3
uniprot id: I0FFS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9544:LOC100424965
gene id: 9544:LOC100424965
uniprot id: A0A5K1VME9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:ALPL
gene id: 9544:ALPL
uniprot id: A0A1D5R5B1
uniprot id: A0A8J8Y875
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9544:NDUFAF7
gene id: 9544:NDUFAF7
uniprot id: G7N9U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9544:ZNF444
gene id: 9544:ZNF444
uniprot id: I2CYQ1
names: Subcellular Location Annotation
messages: Nucleus

9544:DHX9
gene id: 9544:DHX9
uniprot id: F6W5Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9544:HCST
gene id: 9544:HCST
uniprot id: Q8WNQ9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAP10 family.
messages: Homodimer; Disulfide-linked. Heterohexamer composed of four subunits of HCST/DAP10 and two subunits of KLRK1. Interacts (via transmembrane domain) with KLRK1 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Interacts with PIK3R1 and GRB2. Interacts with CLEC5A. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP (By similarity). Interacts with CD300H (By similarity).
messages: Membrane
messages: O-glycosylated.
messages: Phosphorylated; PIK3R1 and GRB2 associate specifically with tyrosine-phosphorylated HCST.
messages: Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity).

9544:MFGE8
gene id: 9544:MFGE8
uniprot id: A0A8J8Y1U3
uniprot id: G7MYS0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:C15H9orf116
gene id: 9544:C15H9orf116
uniprot id: A0A8J8XCZ1
uniprot id: G7NF86
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9544:CNDP2
gene id: 9544:CNDP2
uniprot id: F7EW08
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9544:FOXO4
gene id: 9544:FOXO4
uniprot id: A0A8J8YSG8
uniprot id: G7NRU9
names: Subcellular Location Annotation
messages: Nucleus

9544:LAMP2
gene id: 9544:LAMP2
uniprot id: F6TJH8
uniprot id: F7BCK9
uniprot id: F7BCN1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9544:IZUMO3
gene id: 9544:IZUMO3
uniprot id: A0A5F7ZES2
uniprot id: A0A5F7ZV17
names: Similarity
messages: Belongs to the Izumo family.

9544:GPR155
gene id: 9544:GPR155
uniprot id: F7HIE7
names: Subcellular Location Annotation
messages: Membrane

9544:UBAC2
gene id: 9544:UBAC2
uniprot id: H9Z8F4
names: Subcellular Location Annotation
messages: Membrane

9544:PDGFB
gene id: 9544:PDGFB
uniprot id: A0A1D5Q4I7
uniprot id: A0A8J8XHM2
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9544:PTAFR
gene id: 9544:PTAFR
uniprot id: A0A8J8XNR4
uniprot id: F7HEP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9544:SLC27A2
gene id: 9544:SLC27A2
uniprot id: G7MXA2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:FTL
gene id: 9544:FTL
uniprot id: A0A1D5QQF1
uniprot id: A0A8J8YAV1
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9544:TMEM98
gene id: 9544:TMEM98
uniprot id: A0A8J8YK67
uniprot id: G7NGU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9544:UBL4A
gene id: 9544:UBL4A
uniprot id: F7GKS2
names: Subcellular Location Annotation
messages: cytosol

9544:IRF2
gene id: 9544:IRF2
uniprot id: A0A8J8YJ22
uniprot id: B6CJX8
uniprot id: H9Z8N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9544:SLC6A17
gene id: 9544:SLC6A17
uniprot id: A0A8J8XCD5
uniprot id: G7MIF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9544:KIF22
gene id: 9544:KIF22
uniprot id: G7NQH8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:CSNK2A2
gene id: 9544:CSNK2A2
uniprot id: H9ENR6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:HEXIM1
gene id: 9544:HEXIM1
uniprot id: A0A8J8Y2N7
uniprot id: F7BGX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9544:MFN1
gene id: 9544:MFN1
uniprot id: F6ZJ43
uniprot id: H9ZB20
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9544:HARS
gene id: 9544:HARS
uniprot id: A0A8J8YAB7
uniprot id: G7MUZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9544:TRIM54
gene id: 9544:TRIM54
uniprot id: A0A8J8XU71
uniprot id: F7B8H2
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9544:FOXP4
gene id: 9544:FOXP4
uniprot id: A0A8J8YLM8
uniprot id: G7MPA1
uniprot id: H9Z523
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC9A5
gene id: 9544:SLC9A5
uniprot id: A0A5F8AIS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

9544:TMEM33
gene id: 9544:TMEM33
uniprot id: A0A5F8A8S2
uniprot id: A0A8J8XUJ5
uniprot id: F7H2H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9544:LAMP5
gene id: 9544:LAMP5
uniprot id: G7N2Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Membrane

9544:ZHX2
gene id: 9544:ZHX2
uniprot id: H9ERC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9544:TPH1
gene id: 9544:TPH1
uniprot id: F7B7G4
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9544:PML
gene id: 9544:PML
uniprot id: F7HSN1
uniprot id: H9ZA72
uniprot id: Q15JD4
names: Subcellular Location Annotation
messages: Cytoplasm

9544:FSCN3
gene id: 9544:FSCN3
uniprot id: G7MMA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9544:DUS4L
gene id: 9544:DUS4L
uniprot id: A0A8J8XHC8
uniprot id: F7HK92
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9544:HARS2
gene id: 9544:HARS2
uniprot id: A0A8J8XK88
uniprot id: G7MUZ3
uniprot id: I2CY73
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9544:SMG5
gene id: 9544:SMG5
uniprot id: A0A5F8ADX1
uniprot id: A0A8J8XIH2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

9544:PIK3CG
gene id: 9544:PIK3CG
uniprot id: A0A8J8YMM1
uniprot id: F6W7C8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9544:SKP1
gene id: 9544:SKP1
uniprot id: I0FL62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

9544:PSENEN
gene id: 9544:PSENEN
uniprot id: A0A8J8XL39
uniprot id: F6PQB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9544:PQLC1
gene id: 9544:PQLC1
uniprot id: F7GUY0
names: Subcellular Location Annotation
messages: Membrane

9544:KIFC3
gene id: 9544:KIFC3
uniprot id: A0A1D5Q1J5
uniprot id: A0A1D5QE16
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:CXCL9
gene id: 9544:CXCL9
uniprot id: Q8MIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9544:TIMM23
gene id: 9544:TIMM23
uniprot id: A0A8J8Y996
uniprot id: F7A0I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9544:SEC11A
gene id: 9544:SEC11A
uniprot id: A0A1D5R670
uniprot id: A0A8J8XB25
uniprot id: F7D839
uniprot id: G7MYQ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:MOSPD1
gene id: 9544:MOSPD1
uniprot id: F6TYI4
names: Subcellular Location Annotation
messages: Membrane

9544:ABLIM2
gene id: 9544:ABLIM2
uniprot id: I2CVE5
names: Subcellular Location Annotation
messages: Cytoplasm

9544:SSRP1
gene id: 9544:SSRP1
uniprot id: A0A8J8XMD6
uniprot id: F7E0V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9544:TRAF5
gene id: 9544:TRAF5
uniprot id: A0A5F8AI01
uniprot id: F7FNK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9544:GRB14
gene id: 9544:GRB14
uniprot id: F6QF39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9544:CHML
gene id: 9544:CHML
uniprot id: A0A8J8XZW5
uniprot id: G7MFL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9544:APTX
gene id: 9544:APTX
uniprot id: F7C3L9
uniprot id: H9YUS5
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

9544:FABP2
gene id: 9544:FABP2
uniprot id: F7FGH2
names: Function
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9544:NFS1
gene id: 9544:NFS1
uniprot id: F7CHF9
uniprot id: G7N4Y5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9544:RPL18
gene id: 9544:RPL18
uniprot id: F7H349
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Rough endoplasmic reticulum

9544:LOC710568
gene id: 9544:LOC710568
uniprot id: A0A5F7Z8I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:ORMDL1
gene id: 9544:ORMDL1
uniprot id: A0A8J8XL06
uniprot id: F7D5L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9544:PTPRU
gene id: 9544:PTPRU
uniprot id: F6R5G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9544:GSTT2B
gene id: 9544:GSTT2B
uniprot id: A0A023JCH0
uniprot id: G8F1C9
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9544:POLR2K
gene id: 9544:POLR2K
uniprot id: F7FMW4
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9544:ISCA2
gene id: 9544:ISCA2
uniprot id: H9EW17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9544:ITM2B
gene id: 9544:ITM2B
uniprot id: F7B0D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9544:TOB2
gene id: 9544:TOB2
uniprot id: A0A8J8XH36
uniprot id: F7HSS9
names: Similarity
messages: Belongs to the BTG family.

9544:HIST1H2AE
gene id: 9544:HIST1H2AE
uniprot id: G7MR18
uniprot id: G7MR36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:TMEM163
gene id: 9544:TMEM163
uniprot id: A0A5F7ZL78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Membrane
messages: synaptic vesicle membrane

9544:ALDH5A1
gene id: 9544:ALDH5A1
uniprot id: F6T9P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

9544:ANP32E
gene id: 9544:ANP32E
uniprot id: H9G093
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9544:DDR2
gene id: 9544:DDR2
uniprot id: A0A8J8YII3
uniprot id: F7HJQ2
names: Subcellular Location Annotation
messages: Membrane

9544:EFNB1
gene id: 9544:EFNB1
uniprot id: A0A8J8XRL4
uniprot id: G7NRT3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:LOC697888
gene id: 9544:LOC697888
uniprot id: F7GPE9
names: Similarity
messages: Belongs to the SPAN-X family.

9544:SLC9A8
gene id: 9544:SLC9A8
uniprot id: H9FRY8
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9544:LIFR
gene id: 9544:LIFR
uniprot id: F7E0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9544:NUP85
gene id: 9544:NUP85
uniprot id: H9FZZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9544:GABARAPL2
gene id: 9544:GABARAPL2
uniprot id: A0A8J8YM91
uniprot id: F6W1M5
names: Similarity
messages: Belongs to the ATG8 family.

9544:HHATL
gene id: 9544:HHATL
uniprot id: F7HRJ3
names: Subcellular Location Annotation
messages: Membrane

9544:SLC25A26
gene id: 9544:SLC25A26
uniprot id: A0A1D5RK04
uniprot id: A0A8J8XZ60
uniprot id: F7GC48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:ARCN1
gene id: 9544:ARCN1
uniprot id: H9Z8P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9544:RNF146
gene id: 9544:RNF146
uniprot id: A0A8J8XK00
uniprot id: F6SP59
uniprot id: F7GUD1
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9544:KCNC1
gene id: 9544:KCNC1
uniprot id: A0A8J8XEZ7
uniprot id: F7GWN3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:PNRC2
gene id: 9544:PNRC2
uniprot id: A0A8J8XPT9
uniprot id: F6PZL3
names: Subcellular Location Annotation
messages: Nucleus

9544:PRDX6
gene id: 9544:PRDX6
uniprot id: F7F6H0
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9544:TSC22D4
gene id: 9544:TSC22D4
uniprot id: H9G096
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9544:VPS29
gene id: 9544:VPS29
uniprot id: F7H8D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9544:CHST6
gene id: 9544:CHST6
uniprot id: F6S4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9544:BCLAF3
gene id: 9544:BCLAF3
uniprot id: A0A5F8AE95
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9544:SCRN2
gene id: 9544:SCRN2
uniprot id: F7HMF1
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9544:OR2B3
gene id: 9544:OR2B3
uniprot id: A0A8J8YN75
uniprot id: F7GT01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ONECUT1
gene id: 9544:ONECUT1
uniprot id: F7BS57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9544:SLC25A5
gene id: 9544:SLC25A5
uniprot id: I0FR46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9544:PFN1
gene id: 9544:PFN1
uniprot id: F7H2A5
names: Similarity
messages: Belongs to the profilin family.

9544:FAM13C
gene id: 9544:FAM13C
uniprot id: F6S9M8
names: Similarity
messages: Belongs to the FAM13 family.

9544:DPCD
gene id: 9544:DPCD
uniprot id: I2CWU3
names: Similarity
messages: Belongs to the DPCD family.

9544:KCNT2
gene id: 9544:KCNT2
uniprot id: F7AJ34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:LOX
gene id: 9544:LOX
uniprot id: A0A5F8A8E7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9544:LOC697706
gene id: 9544:LOC697706
uniprot id: A0A5F8AGU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:LOC107000809
gene id: 9544:LOC107000809
uniprot id: F7GZH5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9544:LOC704637
gene id: 9544:LOC704637
uniprot id: H9FV51
names: Similarity
messages: Belongs to the FAH family.

9544:LMOD2
gene id: 9544:LMOD2
uniprot id: F7BU89
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9544:HYAL2
gene id: 9544:HYAL2
uniprot id: A0A8J8XWP6
uniprot id: F7H9X1
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9544:MRPL32
gene id: 9544:MRPL32
uniprot id: A0A5F7ZKH0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9544:SLC44A2
gene id: 9544:SLC44A2
uniprot id: A0A1D5QHJ6
uniprot id: A0A5K1UNU9
uniprot id: F6RT54
uniprot id: H9ES59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9544:SQSTM1
gene id: 9544:SQSTM1
uniprot id: H9G1C8
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9544:CMAS
gene id: 9544:CMAS
uniprot id: F7H7Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

9544:ARPP19
gene id: 9544:ARPP19
uniprot id: H9FP00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9544:TSPAN2
gene id: 9544:TSPAN2
uniprot id: F7HA08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:WASF1
gene id: 9544:WASF1
uniprot id: A0A5F7ZYV7
uniprot id: A0A8J8Y239
uniprot id: G7MQW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9544:HAPLN2
gene id: 9544:HAPLN2
uniprot id: F7FY38
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:HMGB3
gene id: 9544:HMGB3
uniprot id: F6TE46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9544:CHUK
gene id: 9544:CHUK
uniprot id: A0A1D5Q734
uniprot id: A0A8J8XZ28
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:ARL6IP5
gene id: 9544:ARL6IP5
uniprot id: A0A8J8XX32
uniprot id: F7FCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9544:FGF10
gene id: 9544:FGF10
uniprot id: A0A8J8Y005
uniprot id: F6RWC6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:RPS14
gene id: 9544:RPS14
uniprot id: F7HI21
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9544:FAM102A
gene id: 9544:FAM102A
uniprot id: A0A8J8XGM9
uniprot id: H9YUC1
names: Similarity
messages: Belongs to the EEIG family.

9544:CD99
gene id: 9544:CD99
uniprot id: F6ZS69
uniprot id: I0FHX9
names: Similarity
messages: Belongs to the CD99 family.

9544:MRPS24
gene id: 9544:MRPS24
uniprot id: A0A1D5QPE4
uniprot id: A0A8J8Y088
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9544:POMGNT2
gene id: 9544:POMGNT2
uniprot id: A0A8J8YKD9
uniprot id: G7MIX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:TRMT112
gene id: 9544:TRMT112
uniprot id: F7CV76
names: Similarity
messages: Belongs to the TRM112 family.

9544:ZC3H15
gene id: 9544:ZC3H15
uniprot id: A0A8J8Y918
uniprot id: F7H9Q2
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9544:ADAMTS14
gene id: 9544:ADAMTS14
uniprot id: F7FHT3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:OTULIN
gene id: 9544:OTULIN
uniprot id: A0A5F8ABU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9544:GJB6
gene id: 9544:GJB6
uniprot id: A0A8J8XYN2
uniprot id: G7NJQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:PPM1D
gene id: 9544:PPM1D
uniprot id: I0FVT7
names: Similarity
messages: Belongs to the PP2C family.

9544:TUBGCP4
gene id: 9544:TUBGCP4
uniprot id: A0A1D5R0M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9544:CD46
gene id: 9544:CD46
uniprot id: F7DTF4
uniprot id: F7DTG0
uniprot id: I0FRS6
uniprot id: O19127
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

9544:TBXT
gene id: 9544:TBXT
uniprot id: F7HNS0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:SNX3
gene id: 9544:SNX3
uniprot id: A0A8J8XNW8
uniprot id: F6W8H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

9544:TAFA1
gene id: 9544:TAFA1
uniprot id: F6SYD9
names: Similarity
messages: Belongs to the TAFA family.

9544:ME3
gene id: 9544:ME3
uniprot id: H9FP20
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9544:PIGU
gene id: 9544:PIGU
uniprot id: F6UA81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:LIPT2
gene id: 9544:LIPT2
uniprot id: F6XJJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

9544:CHURC1
gene id: 9544:CHURC1
uniprot id: A0A1D5RA12
names: Similarity
messages: Belongs to the Churchill family.

9544:MORF4L1
gene id: 9544:MORF4L1
uniprot id: F6VZK6
uniprot id: H9YYT5
names: Subcellular Location Annotation
messages: Nucleus

9544:GCK
gene id: 9544:GCK
uniprot id: A0A1D5QSW0
uniprot id: A0A8J8Y216
uniprot id: F6PLU3
names: Similarity
messages: Belongs to the hexokinase family.

9544:MEFV
gene id: 9544:MEFV
uniprot id: F7DTD6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:LOXL1
gene id: 9544:LOXL1
uniprot id: F6Q5T0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9544:KCTD10
gene id: 9544:KCTD10
uniprot id: H9G0I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9544:CCT2
gene id: 9544:CCT2
uniprot id: I0FNJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9544:C5AR1
gene id: 9544:C5AR1
uniprot id: F7H5Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9544:ATXN3
gene id: 9544:ATXN3
uniprot id: H9FUL0
names: Subcellular Location Annotation
messages: Nucleus

9544:TACR1
gene id: 9544:TACR1
uniprot id: Q2WGM1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9544:GIMAP4
gene id: 9544:GIMAP4
uniprot id: A0A8J8YAF7
uniprot id: H9FWQ2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9544:TSPAN18
gene id: 9544:TSPAN18
uniprot id: F6YG23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:PDSS1
gene id: 9544:PDSS1
uniprot id: A0A5F8AIJ9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9544:ABCB5
gene id: 9544:ABCB5
uniprot id: F7CIT5
names: Subcellular Location Annotation
messages: Membrane

9544:CCL25
gene id: 9544:CCL25
uniprot id: Q8HYP3
names: Subcellular Location Annotation
messages: Secreted

9544:HIST3H3
gene id: 9544:HIST3H3
uniprot id: A0A8J8XR43
uniprot id: G7MEC7
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:TOMM22
gene id: 9544:TOMM22
uniprot id: F6YG80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9544:PDHA1
gene id: 9544:PDHA1
uniprot id: F7HBM4
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9544:SHH
gene id: 9544:SHH
uniprot id: A0A5F7ZJT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9544:EAF1
gene id: 9544:EAF1
uniprot id: G7MJV9
names: Similarity
messages: Belongs to the EAF family.

9544:DKC1
gene id: 9544:DKC1
uniprot id: H9Z5Y0
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9544:EIF4A2
gene id: 9544:EIF4A2
uniprot id: F7GUR7
uniprot id: G7MK70
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9544:NANOS2
gene id: 9544:NANOS2
uniprot id: A0A8J8XZ14
uniprot id: F7HIW0
names: Similarity
messages: Belongs to the nanos family.

9544:NDUFS2
gene id: 9544:NDUFS2
uniprot id: H9FMK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 49 kDa subunit family.
messages: Mitochondrion inner membrane

9544:MRPL15
gene id: 9544:MRPL15
uniprot id: A0A8J8XTM4
uniprot id: G7MZC9
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9544:MRPL11
gene id: 9544:MRPL11
uniprot id: A0A8J8YL97
uniprot id: F7DTN4
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9544:RAD51
gene id: 9544:RAD51
uniprot id: A0A1D5QVN1
uniprot id: A0A8J8XU32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9544:ARPC1A
gene id: 9544:ARPC1A
uniprot id: H9FNS7
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9544:EGFR
gene id: 9544:EGFR
uniprot id: P55245
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation. Heterodimer with ERBB2. Forms a complex with CCDC88A/GIV (via SH2-like regions) and GNAI3 which leads to enhanced EGFR signaling and triggering of cell migration; binding to CCDC88A requires autophosphorylation of the EGFR C-terminal region, and ligand stimulation is required for recruitment of GNAI3 to the complex. Interacts with ERRFI1; inhibits dimerization of the kinase domain and autophosphorylation. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts with GRB2; an adapter protein coupling the receptor to downstream signaling pathways. Interacts with GAB2; involved in signaling downstream of EGFR. Interacts with STAT3; mediates EGFR downstream signaling in cell proliferation. Interacts with RIPK1; involved in NF-kappa-B activation. Interacts (autophosphorylated) with CBL, CBLB and CBLC; involved in EGFR ubiquitination and regulation; interaction with CBL is reduced in the presence of tensin TNS4. Interacts with SOCS5; regulates EGFR degradation through ELOC- and ELOB-mediated ubiquitination and proteasomal degradation. Interacts with PRMT5; methylates EGFR and enhances interaction with PTPN6. Interacts (phosphorylated) with PTPN6; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with COPG1; essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts with PCNA; positively regulates PCNA. Interacts with PELP1. Interacts with MUC1. Interacts with AP2M1. Interacts with FER. May interact with EPS8; mediates EPS8 phosphorylation. Interacts (via SH2 domains) with GRB2, NCK1 and NCK2. Interacts with ATXN2. Interacts with GAREM1. Interacts (ubiquitinated) with ANKRD13A/B/D; the interaction is direct and may regulate EGFR internalization after EGF stimulation. Inter…
messages: Cell membrane
messages: Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK constitute immediate regulatory mechanisms. Upon EGF-binding phosphorylates EPS15 that regulates EGFR endocytosis and activity. Moreover, inducible feedback inhibitors including LRIG1, SOCS4, SOCS5 and ERRFI1 constitute alternative regulatory mechanisms for the EGFR signaling.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Hypothalamus.
messages: Levels in the medial basal hypothalamus and preoptic area are elevated during neonatal life (1 week-6 months), decrease during juvenile development (8-18 months) and markedly increase during the expected time of puberty (30-36 months).
messages: Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197.
messages: Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting (By similarity). Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occurs. Deubiquitination by OTUD7B prevents degradation. Ubiquitinated by RNF115 and RNF126 (By similarity). Ubiquitinated by ZNRF1 or CBL at different lysines in response to EGF stimulation; leading to recruitment of the ESCRT machinery and subsequent degradation in the lysosomes (By similarity). Deubiquitinated by UCHL1 leading to the inhibition of its degradation (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Palmitoylated on Cys residues by ZDHHC20. Palmitoylation inhibits internalization after ligand binding, and increases the persistence of tyrosine-phosphorylated EGFR at the cell membrane. Palmitoylation increases the amplitude and duration of EGFR signaling.
messages: Phosphorylated on Tyr residues in response to EGF. Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Dephosphorylated by PTPN1 and PTPN2.
messages: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (By similarity). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (By similarity). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity).

9544:ANAPC2
gene id: 9544:ANAPC2
uniprot id: A0A8J8YB93
uniprot id: F7G3J3
names: Similarity
messages: Belongs to the cullin family.

9544:ASB7
gene id: 9544:ASB7
uniprot id: A0A8J8XKM3
uniprot id: F7G134
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:ACTB
gene id: 9544:ACTB
uniprot id: F6TIK4
uniprot id: Q6RHR8
uniprot id: Q6UIS1
names: Similarity
messages: Belongs to the actin family.

9544:WTAP
gene id: 9544:WTAP
uniprot id: H9Z1B4
names: Similarity
messages: Belongs to the fl(2)d family.

9544:EIF5B
gene id: 9544:EIF5B
uniprot id: A0A5F7ZUP7
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

9544:LOC703889
gene id: 9544:LOC703889
uniprot id: A0A8J8Y153
uniprot id: F7BRX2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:DPYSL4
gene id: 9544:DPYSL4
uniprot id: H9H4A5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9544:SYK
gene id: 9544:SYK
uniprot id: A0A5F7ZCV9
uniprot id: A0A8J8Y2Y3
uniprot id: F7GLV6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9544:CHM
gene id: 9544:CHM
uniprot id: A0A8J8XWL3
uniprot id: G7NSD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9544:KIT
gene id: 9544:KIT
uniprot id: A0A8J8YKB5
uniprot id: F6V858
uniprot id: H9FU74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9544:SEC31A
gene id: 9544:SEC31A
uniprot id: F6WSK0
uniprot id: H9FRF6
uniprot id: H9FRF7
uniprot id: H9FRF8
uniprot id: H9Z6G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

9544:P2RY4
gene id: 9544:P2RY4
uniprot id: G7NRU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PABPC1
gene id: 9544:PABPC1
uniprot id: I0FGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9544:DNMT3A
gene id: 9544:DNMT3A
uniprot id: F6QRP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9544:LDHA
gene id: 9544:LDHA
uniprot id: A0A8J8XQS5
uniprot id: F6R1N2
uniprot id: G7NDS7
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9544:SSBP4
gene id: 9544:SSBP4
uniprot id: F7H6D9
uniprot id: H9FQR2
names: Subcellular Location Annotation
messages: Nucleus

9544:GTF2B
gene id: 9544:GTF2B
uniprot id: H9Z849
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIB family.
messages: Nucleus

9544:CKB
gene id: 9544:CKB
uniprot id: I0FP16
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9544:BRMS1L
gene id: 9544:BRMS1L
uniprot id: F7B4M6
names: Subcellular Location Annotation
messages: Nucleus

9544:UNC5CL
gene id: 9544:UNC5CL
uniprot id: F7H6L1
names: Similarity
messages: Belongs to the unc-5 family.

9544:IRF8
gene id: 9544:IRF8
uniprot id: A0A8J8Y1G4
uniprot id: F7HIN3
names: Subcellular Location Annotation
messages: Nucleus

9544:SCAI
gene id: 9544:SCAI
uniprot id: A0A5F7ZS23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAI family.
messages: Cytoplasm
messages: Interacts with DIAPH1. Forms a nuclear ternary complex with MRTFA and SRF.
messages: Nucleus
messages: Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity.

9544:CRYGD
gene id: 9544:CRYGD
uniprot id: A0A8J8YEX0
uniprot id: F6PWY4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9544:RNF167
gene id: 9544:RNF167
uniprot id: G7NI39
names: Subcellular Location Annotation
messages: Membrane

9544:ARRDC2
gene id: 9544:ARRDC2
uniprot id: H9EVV3
names: Similarity
messages: Belongs to the arrestin family.

9544:PPARD
gene id: 9544:PPARD
uniprot id: A0A8J8YK55
uniprot id: G7MRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:ZPR1
gene id: 9544:ZPR1
uniprot id: A0A5K1UBM7
names: Similarity
messages: Belongs to the ZPR1 family.

9544:CAPZA1
gene id: 9544:CAPZA1
uniprot id: H9G0D0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9544:ING1
gene id: 9544:ING1
uniprot id: F6UPA5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9544:API5
gene id: 9544:API5
uniprot id: F7EXC8
uniprot id: H9G121
names: Similarity
messages: Belongs to the API5 family.

9544:SFXN2
gene id: 9544:SFXN2
uniprot id: F7FUJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9544:MCHR2
gene id: 9544:MCHR2
uniprot id: G7MPZ4
uniprot id: Q8MJ88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
messages: Specifically expressed in the brain with highest levels in cerebral cortex, hippocampus and hypothalamus, and lower levels in caudate nucleus, putamen and thalamus.

9544:SUSD3
gene id: 9544:SUSD3
uniprot id: A0A5F7ZKK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:INTS10
gene id: 9544:INTS10
uniprot id: F7HQF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9544:HBA1
gene id: 9544:HBA1
uniprot id: A0A8J8XNB7
uniprot id: G7NQC3
uniprot id: P63108
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9544:EXOC6
gene id: 9544:EXOC6
uniprot id: F7FZN9
uniprot id: F7FZP8
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9544:OPA3
gene id: 9544:OPA3
uniprot id: I2CXP2
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

9544:SIX5
gene id: 9544:SIX5
uniprot id: F7GEZ3
names: Subcellular Location Annotation
messages: Nucleus

9544:ACTL7B
gene id: 9544:ACTL7B
uniprot id: A0A8J8Y5N5
uniprot id: F6TAK4
names: Similarity
messages: Belongs to the actin family.

9544:HDHD3
gene id: 9544:HDHD3
uniprot id: A0A8J8YQP3
uniprot id: F7GY57
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9544:PTH2R
gene id: 9544:PTH2R
uniprot id: F7GM38
names: Subcellular Location Annotation
messages: Membrane

9544:RENBP
gene id: 9544:RENBP
uniprot id: F6YUM9
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

9544:APEX2
gene id: 9544:APEX2
uniprot id: F6VBU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9544:CMTM3
gene id: 9544:CMTM3
uniprot id: F7HQG0
names: Subcellular Location Annotation
messages: Membrane

9544:OR4K13
gene id: 9544:OR4K13
uniprot id: F7BYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PRKD3
gene id: 9544:PRKD3
uniprot id: A0A1D5QG47
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9544:DLL1
gene id: 9544:DLL1
uniprot id: F7HB47
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9544:ITPK1
gene id: 9544:ITPK1
uniprot id: H9FU36
names: Similarity
messages: Belongs to the ITPK1 family.

9544:ST6GAL2
gene id: 9544:ST6GAL2
uniprot id: F7GGB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

9544:GSTA1
gene id: 9544:GSTA1
uniprot id: A0A5F7ZAC1
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9544:CPNE9
gene id: 9544:CPNE9
uniprot id: I2CTX2
names: Similarity
messages: Belongs to the copine family.

9544:HOXC10
gene id: 9544:HOXC10
uniprot id: A2D635
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9544:PYCR3
gene id: 9544:PYCR3
uniprot id: A0A5F8AP82
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9544:ACTL6B
gene id: 9544:ACTL6B
uniprot id: A0A8J8YH38
uniprot id: G7MNV3
names: Similarity
messages: Belongs to the actin family.

9544:PRRX1
gene id: 9544:PRRX1
uniprot id: A0A8J8XXA8
uniprot id: F6R2P0
uniprot id: F6R2Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9544:IP6K1
gene id: 9544:IP6K1
uniprot id: A0A8J8YPV5
uniprot id: F7GRE2
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9544:STX5
gene id: 9544:STX5
uniprot id: A0A8J8Y346
uniprot id: H9Z1T6
names: Similarity
messages: Belongs to the syntaxin family.

9544:TAS2R13
gene id: 9544:TAS2R13
uniprot id: Q645T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:SLC10A5
gene id: 9544:SLC10A5
uniprot id: A0A1D5Q7H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9544:UBE2D1
gene id: 9544:UBE2D1
uniprot id: A0A8J8YC37
uniprot id: G7N2F6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:LOC100426750
gene id: 9544:LOC100426750
uniprot id: A0A8J8XC54
uniprot id: F7HEN1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:FAM20B
gene id: 9544:FAM20B
uniprot id: A0A8J8YKY0
uniprot id: H9G2M7
names: Similarity
messages: Belongs to the FAM20 family.

9544:SDHAF3
gene id: 9544:SDHAF3
uniprot id: F6TUZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9544:TPK1
gene id: 9544:TPK1
uniprot id: A0A8J8YSB2
uniprot id: F7F874
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9544:RAD18
gene id: 9544:RAD18
uniprot id: F7GJA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9544:PTPRN2
gene id: 9544:PTPRN2
uniprot id: F6UWH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9544:MRPL47
gene id: 9544:MRPL47
uniprot id: F6ZQ94
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9544:ARL5B
gene id: 9544:ARL5B
uniprot id: F6SWA4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9544:TOR1A
gene id: 9544:TOR1A
uniprot id: A0A5F8A5L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9544:MON1B
gene id: 9544:MON1B
uniprot id: H9EVR5
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9544:RSPO1
gene id: 9544:RSPO1
uniprot id: A0A1D5Q7L9
names: Similarity
messages: Belongs to the R-spondin family.

9544:MRGPRX3
gene id: 9544:MRGPRX3
uniprot id: Q2LL16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
messages: Cell membrane
messages: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

9544:GUSBA
gene id: 9544:GUSBA
uniprot id: H9FTK4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

9544:AOX2
gene id: 9544:AOX2
uniprot id: M1ZMK3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9544:RORB
gene id: 9544:RORB
uniprot id: A0A1D5QER8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9544:CHST7
gene id: 9544:CHST7
uniprot id: F7CNI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9544:KCTD11
gene id: 9544:KCTD11
uniprot id: A0A8J8XKX2
uniprot id: F7HLN0
names: Subcellular Location Annotation
messages: Cell membrane

9544:LHX1
gene id: 9544:LHX1
uniprot id: A0A8J8XTP5
uniprot id: F7F4Z5
names: Subcellular Location Annotation
messages: Nucleus

9544:RAB21
gene id: 9544:RAB21
uniprot id: A0A1D5QIE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: trans-Golgi network

9544:FES
gene id: 9544:FES
uniprot id: A0A8J8XB40
uniprot id: G7MVY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9544:NUDT5
gene id: 9544:NUDT5
uniprot id: A0A1D5QNV6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9544:RTN4IP1
gene id: 9544:RTN4IP1
uniprot id: A0A8J8YF21
uniprot id: G7MQ06
uniprot id: I2CTU3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9544:STX1B
gene id: 9544:STX1B
uniprot id: H9EME4
names: Similarity
messages: Belongs to the syntaxin family.

9544:PAXBP1
gene id: 9544:PAXBP1
uniprot id: F7DLV0
names: Similarity
messages: Belongs to the GCF family.

9544:EIF3D
gene id: 9544:EIF3D
uniprot id: A0A1D5Q459
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9544:ABCA1
gene id: 9544:ABCA1
uniprot id: A0A8J8YKU0
uniprot id: G7NEL5
names: Subcellular Location Annotation
messages: Membrane

9544:TNPO1
gene id: 9544:TNPO1
uniprot id: H9EQ61
uniprot id: H9EQ62
names: Subcellular Location Annotation
messages: Cytoplasm

9544:BMP2
gene id: 9544:BMP2
uniprot id: A0A8J8YQ20
uniprot id: G7N2Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9544:KCNG1
gene id: 9544:KCNG1
uniprot id: F6Z0A7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:FBXO32
gene id: 9544:FBXO32
uniprot id: F7GVE8
names: Subcellular Location Annotation
messages: Nucleus

9544:LOC106995404
gene id: 9544:LOC106995404
uniprot id: A0A5F8AA24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9544:TULP3
gene id: 9544:TULP3
uniprot id: I2CXK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9544:IZUMO4
gene id: 9544:IZUMO4
uniprot id: F6RDJ1
names: Similarity
messages: Belongs to the Izumo family.

9544:TM7SF3
gene id: 9544:TM7SF3
uniprot id: G7N6L0
names: Subcellular Location Annotation
messages: Membrane

9544:PDPR
gene id: 9544:PDPR
uniprot id: A0A8J8XKT6
uniprot id: F6RY22
names: Similarity
messages: Belongs to the GcvT family.

9544:CD226
gene id: 9544:CD226
uniprot id: O18906
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.
messages: Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
messages: Phosphorylated.

9544:PELI2
gene id: 9544:PELI2
uniprot id: H9YY61
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9544:SPINLW1
gene id: 9544:SPINLW1
uniprot id: Q9BDL1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Monomer. Homodimer. Homomultimers. Interacts with SEMG1 (via 164-283 AA). Interacts with LTF. Found in a complex with LTF, CLU, EPPIN and SEMG1.
messages: Secreted
messages: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity).

9544:ALB
gene id: 9544:ALB
uniprot id: F7HCH0
uniprot id: Q28522
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ALB/AFP/VDB family.
messages: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-265 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
messages: Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.
messages: Phosphorylated by FAM20C in the extracellular medium.
messages: Plasma.
messages: Secreted

9544:ADTRP
gene id: 9544:ADTRP
uniprot id: A0A1D5Q198
uniprot id: F7HLH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9544:MED14
gene id: 9544:MED14
uniprot id: A0A1D5Q627
uniprot id: A0A1D5QHV7
uniprot id: F7BPL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9544:TLN1
gene id: 9544:TLN1
uniprot id: A0A8J8XDX9
uniprot id: G7NFD2
names: Subcellular Location Annotation
messages: cytoskeleton

9544:GABRB2
gene id: 9544:GABRB2
uniprot id: D1LYT2
uniprot id: E5D2Z3
uniprot id: F7EV84
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by benzodiazepines and the anesthetic etomidate (By similarity). Inhibited by the antagonist bicuculline (By similarity).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Glycosylated.
messages: Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity). Interacts with UBQLN1 (By similarity). Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity). May interact with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity).
messages: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The extracellular domain contributes to synaptic contact formation.

9544:SIX1
gene id: 9544:SIX1
uniprot id: A0A5F8AGF5
names: Subcellular Location Annotation
messages: Nucleus

9544:HCRTR1
gene id: 9544:HCRTR1
uniprot id: A0A8J8YNB9
uniprot id: F7FE63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:SFXN4
gene id: 9544:SFXN4
uniprot id: I0FP47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9544:NDUFAB1
gene id: 9544:NDUFAB1
uniprot id: F7AF75
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9544:CAPN5
gene id: 9544:CAPN5
uniprot id: F7EDU0
names: Similarity
messages: Belongs to the peptidase C2 family.

9544:PPP2R5D
gene id: 9544:PPP2R5D
uniprot id: H9FWP2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9544:TIMM21
gene id: 9544:TIMM21
uniprot id: F7FB39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9544:RPTOR
gene id: 9544:RPTOR
uniprot id: H9EN45
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9544:CRABP1
gene id: 9544:CRABP1
uniprot id: G7MYF8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:SMIM19
gene id: 9544:SMIM19
uniprot id: A0A8J8XRT9
uniprot id: G7MZ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9544:PSMD9
gene id: 9544:PSMD9
uniprot id: G7N617
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9544:ACE2
gene id: 9544:ACE2
uniprot id: B6DUG6
uniprot id: F7AH40
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9544:LOC721299
gene id: 9544:LOC721299
uniprot id: A0A5F8ACJ4
names: Similarity
messages: Belongs to the actin family.

9544:GPR1
gene id: 9544:GPR1
uniprot id: G7N8R0
uniprot id: O97664
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane
messages: Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (By similarity). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).

9544:RRP15
gene id: 9544:RRP15
uniprot id: F6ZJY2
names: Similarity
messages: Belongs to the RRP15 family.

9544:LOC711104
gene id: 9544:LOC711104
uniprot id: A0A1D5QI76
uniprot id: A0A1D5R338
names: Similarity
messages: Belongs to the Luc7 family.

9544:LEPROT
gene id: 9544:LEPROT
uniprot id: H9FW54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9544:DEFB124
gene id: 9544:DEFB124
uniprot id: G7N557
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:PRPF31
gene id: 9544:PRPF31
uniprot id: A0A8J8XHU2
uniprot id: F6X6X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Cajal body

9544:CD8B
gene id: 9544:CD8B
uniprot id: F7EXY4
names: Subcellular Location Annotation
messages: Membrane

9544:DERL1
gene id: 9544:DERL1
uniprot id: A0A8J8XMZ5
uniprot id: F6Z7L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9544:SPCS1
gene id: 9544:SPCS1
uniprot id: F7H6U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CDC42SE1
gene id: 9544:CDC42SE1
uniprot id: A0A8J8YR49
uniprot id: F6T0R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9544:GCHFR
gene id: 9544:GCHFR
uniprot id: A0A8J8XBP1
uniprot id: F6Z2K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9544:SLC29A1
gene id: 9544:SLC29A1
uniprot id: A0A8J8YI86
uniprot id: F7GST2
uniprot id: H9YY92
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9544:ITGA2
gene id: 9544:ITGA2
uniprot id: A0A8J8Y857
uniprot id: G7MTQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9544:STN1
gene id: 9544:STN1
uniprot id: F6PY41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9544:CDKN3
gene id: 9544:CDKN3
uniprot id: F7FIB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9544:PROK1
gene id: 9544:PROK1
uniprot id: A0A8J8Y012
uniprot id: F6QPG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9544:TNFSF15
gene id: 9544:TNFSF15
uniprot id: A0A8J8Y7Z5
uniprot id: F6S8F9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9544:ACYP2
gene id: 9544:ACYP2
uniprot id: A0A1D5RJS7
names: Similarity
messages: Belongs to the acylphosphatase family.

9544:TMC3
gene id: 9544:TMC3
uniprot id: F7BM03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9544:PROK2
gene id: 9544:PROK2
uniprot id: F6X0K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9544:CCNI
gene id: 9544:CCNI
uniprot id: F7GP05
names: Similarity
messages: Belongs to the cyclin family.

9544:PRNP
gene id: 9544:PRNP
uniprot id: A0A8J8YKW8
uniprot id: G7N2W1
uniprot id: P67997
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prion family.
messages: Cell membrane
messages: Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.
messages: Golgi apparatus
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
messages: Membrane
messages: Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement. Interacts with KIAA1191.
messages: PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
messages: The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.

9544:ATP5MC1
gene id: 9544:ATP5MC1
uniprot id: F6X104
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9544:KLC4
gene id: 9544:KLC4
uniprot id: F7G101
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9544:TUBB1
gene id: 9544:TUBB1
uniprot id: F6XQ37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9544:SGMS1
gene id: 9544:SGMS1
uniprot id: H9FSM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9544:CDK5R1
gene id: 9544:CDK5R1
uniprot id: A0A8J8XGA9
uniprot id: F6Y8D3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

9544:GCNT4
gene id: 9544:GCNT4
uniprot id: H9Z249
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9544:CAVIN2
gene id: 9544:CAVIN2
uniprot id: A0A8J8YKM7
uniprot id: F7BLE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9544:EXOSC4
gene id: 9544:EXOSC4
uniprot id: F7DHI6
names: Subcellular Location Annotation
messages: Cytoplasm

9544:EIF4EBP3
gene id: 9544:EIF4EBP3
uniprot id: A0A5F8AKH1
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9544:ZZZ3
gene id: 9544:ZZZ3
uniprot id: A0A1D5QUG5
names: Subcellular Location Annotation
messages: Nucleus

9544:NRM
gene id: 9544:NRM
uniprot id: A0A8J8XN81
uniprot id: G7MRG0
uniprot id: Q5TM67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9544:SNRPA
gene id: 9544:SNRPA
uniprot id: A0A1D5Q8H4
uniprot id: A0A8J8YH87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

9544:DAD1
gene id: 9544:DAD1
uniprot id: A0A8J8XL02
uniprot id: G7MX20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9544:SH3BP5
gene id: 9544:SH3BP5
uniprot id: A0A8J8YHI1
uniprot id: G7MJV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9544:DCP1A
gene id: 9544:DCP1A
uniprot id: A0A1D5Q7U9
uniprot id: A0A8J8YT15
names: Similarity
messages: Belongs to the DCP1 family.

9544:LOC693785
gene id: 9544:LOC693785
uniprot id: A0A1D5R8C3
names: Similarity
messages: Belongs to the pro/parathymosin family.

9544:HSPB2
gene id: 9544:HSPB2
uniprot id: A0A5F7ZPR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9544:PABPC4
gene id: 9544:PABPC4
uniprot id: A0A8J8XET5
uniprot id: F6QKA5
uniprot id: F6XFF9
uniprot id: H9YYJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9544:EIF4E
gene id: 9544:EIF4E
uniprot id: H9ENS9
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9544:BOLA3
gene id: 9544:BOLA3
uniprot id: A0A8J8XYC6
uniprot id: F6Y6R2
names: Similarity
messages: Belongs to the BolA/IbaG family.

9544:GJB5
gene id: 9544:GJB5
uniprot id: A0A8J8XC79
uniprot id: F7GQL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:DXO
gene id: 9544:DXO
uniprot id: I2CVZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9544:LRRC8D
gene id: 9544:LRRC8D
uniprot id: A0A8J8XNZ6
uniprot id: F6TCH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9544:EMC7
gene id: 9544:EMC7
uniprot id: A0A8J8XME5
uniprot id: F7GVU4
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

9544:CHRNA1
gene id: 9544:CHRNA1
uniprot id: A0A8J8Y3G7
uniprot id: G7N8C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:POU5F1
gene id: 9544:POU5F1
uniprot id: Q5TM49
names: Biotechnology
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Cytoplasm
messages: ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.
messages: Interacts with PKM. Interacts with WWP2. Interacts with UBE2I and ZSCAN10. Interacts with PCGF1. Interacts with ESRRB; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter; the interaction is DNA independent. Interacts with ZNF322. Interacts with MAPK8 and MAPK9; the interaction allows MAPK8 and MAPK9 to phosphorylate POU5F1 on Ser-355. Interacts (when phosphorylated on Ser-355) with FBXW8. Interacts with FBXW4. Interacts with SOX2 and SOX15; binds synergistically with either SOX2 or SOX15 to DNA (By similarity). Interacts with DDX56 (By similarity).
messages: Nucleus
messages: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
messages: Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The POU-specific domain mediates interaction with PKM.
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency.
messages: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation.

9544:SLC35D1
gene id: 9544:SLC35D1
uniprot id: F6XS30
names: Subcellular Location Annotation
messages: Membrane

9544:NOB1
gene id: 9544:NOB1
uniprot id: A0A8J8Y3K7
uniprot id: H9Z0U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9544:FGF22
gene id: 9544:FGF22
uniprot id: A0A7U3JW23
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:TTC4
gene id: 9544:TTC4
uniprot id: F6QZ42
names: Similarity
messages: Belongs to the TTC4 family.

9544:TXNIP
gene id: 9544:TXNIP
uniprot id: A0A8J8YKE8
uniprot id: F7EDN0
names: Similarity
messages: Belongs to the arrestin family.

9544:DUSP26
gene id: 9544:DUSP26
uniprot id: A0A8J8XRC6
uniprot id: F6RW93
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9544:SPACA4
gene id: 9544:SPACA4
uniprot id: F7H350
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9544:ERO1A
gene id: 9544:ERO1A
uniprot id: H9Z884
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9544:TFCP2
gene id: 9544:TFCP2
uniprot id: A0A8J8XAN2
uniprot id: H9YW38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9544:RASGRP2
gene id: 9544:RASGRP2
uniprot id: H9ENK8
names: Similarity
messages: Belongs to the RASGRP family.

9544:MLH3
gene id: 9544:MLH3
uniprot id: A0A5F8ACA3
uniprot id: F7HAZ3
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9544:CD44
gene id: 9544:CD44
uniprot id: A0A1D5QRB0
uniprot id: A0A8J8XS81
uniprot id: F6ZDZ8
uniprot id: H9Z063
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

9544:PRKCB
gene id: 9544:PRKCB
uniprot id: H9FX30
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9544:INKA1
gene id: 9544:INKA1
uniprot id: F7HMU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9544:HESX1
gene id: 9544:HESX1
uniprot id: A0A1D5R4C4
uniprot id: A0A8J8YQQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

9544:SIAH3
gene id: 9544:SIAH3
uniprot id: A0A8J8YMI8
uniprot id: G7NK32
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9544:CCNA2
gene id: 9544:CCNA2
uniprot id: A0A8J8XEW4
uniprot id: F6WZV1
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9544:UBALD1
gene id: 9544:UBALD1
uniprot id: F6RY82
names: Similarity
messages: Belongs to the UBALD family.

9544:NAA25
gene id: 9544:NAA25
uniprot id: A0A8J8YE03
uniprot id: F6QVJ9
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

9544:MRPL4
gene id: 9544:MRPL4
uniprot id: G7NKZ4
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9544:CYP3A4
gene id: 9544:CYP3A4
uniprot id: Q6PSM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:CXCR1
gene id: 9544:CXCR1
uniprot id: Q2YEG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with IL8. Interacts with GNAI2.
messages: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

9544:OSBPL9
gene id: 9544:OSBPL9
uniprot id: F6QX47
names: Similarity
messages: Belongs to the OSBP family.

9544:MYBL2
gene id: 9544:MYBL2
uniprot id: A0A5K1UA99
names: Subcellular Location Annotation
messages: Nucleus

9544:GRHPR
gene id: 9544:GRHPR
uniprot id: H9G201
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9544:TRAPPC4
gene id: 9544:TRAPPC4
uniprot id: H9EPR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9544:DEFB4
gene id: 9544:DEFB4
uniprot id: B0LFF5
names: Subcellular Location Annotation
messages: Secreted

9544:AVPR1B
gene id: 9544:AVPR1B
uniprot id: F7BAU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

9544:DPH5
gene id: 9544:DPH5
uniprot id: F6S1G5
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9544:CTLA4
gene id: 9544:CTLA4
uniprot id: A0A8J8YNJ8
uniprot id: Q9BDC4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9544:KIF3B
gene id: 9544:KIF3B
uniprot id: A0A8J8YL95
uniprot id: F6S877
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:MOB2
gene id: 9544:MOB2
uniprot id: F6TYM1
uniprot id: H9ZDY9
names: Similarity
messages: Belongs to the MOB1/phocein family.

9544:CDC20
gene id: 9544:CDC20
uniprot id: A0A8J8Y1T0
uniprot id: F7FUI4
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9544:PLPPR1
gene id: 9544:PLPPR1
uniprot id: A0A8J8XZQ4
uniprot id: F7GYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:TFEB
gene id: 9544:TFEB
uniprot id: F7FXN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9544:CBX8
gene id: 9544:CBX8
uniprot id: H9ZBK9
names: Subcellular Location Annotation
messages: Nucleus

9544:LY6G5C
gene id: 9544:LY6G5C
uniprot id: Q863H0
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: N-glycosylated.
messages: Secreted

9544:TM7SF2
gene id: 9544:TM7SF2
uniprot id: A0A8J8XQH7
uniprot id: G7NCG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9544:CD40LG
gene id: 9544:CD40LG
uniprot id: P63304
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9544:AGXT
gene id: 9544:AGXT
uniprot id: A0A8J8YBD3
uniprot id: F7F4Q3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisome

9544:MOSPD3
gene id: 9544:MOSPD3
uniprot id: H9FYH6
names: Subcellular Location Annotation
messages: Membrane

9544:FOXO1
gene id: 9544:FOXO1
uniprot id: F6ZVZ0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:FAM199X
gene id: 9544:FAM199X
uniprot id: A0A8J8XTC2
uniprot id: H9FQ48
names: Similarity
messages: Belongs to the FAM199 family.

9544:SLC17A2
gene id: 9544:SLC17A2
uniprot id: A0A5F8ALS7
uniprot id: A0A8J8XSH9
uniprot id: F7HQK4
names: Subcellular Location Annotation
messages: Membrane

9544:KRT2
gene id: 9544:KRT2
uniprot id: G7N727
names: Similarity
messages: Belongs to the intermediate filament family.

9544:TMEM53
gene id: 9544:TMEM53
uniprot id: G7MGN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9544:B2M
gene id: 9544:B2M
uniprot id: G7MX75
uniprot id: Q6V7J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

9544:NR4A2
gene id: 9544:NR4A2
uniprot id: A0A8J8Y407
uniprot id: G7N845
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9544:MTHFR
gene id: 9544:MTHFR
uniprot id: G7MGV7
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

9544:BUD23
gene id: 9544:BUD23
uniprot id: H9FPI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9544:IL1RN
gene id: 9544:IL1RN
uniprot id: A0A1D5Q1Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9544:RRP36
gene id: 9544:RRP36
uniprot id: A0A5F7ZZX0
uniprot id: A0A5F8A032
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

9544:MBOAT2
gene id: 9544:MBOAT2
uniprot id: H9FPX1
names: Subcellular Location Annotation
messages: Membrane

9544:TAPT1
gene id: 9544:TAPT1
uniprot id: H9Z0V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

9544:BAZ1B
gene id: 9544:BAZ1B
uniprot id: A0A5F8A4T7
names: Subcellular Location Annotation
messages: Nucleus

9544:LETM2
gene id: 9544:LETM2
uniprot id: G7MZ49
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

9544:BGN
gene id: 9544:BGN
uniprot id: A0A8J8XNS5
uniprot id: G7NSJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

9544:NUP50
gene id: 9544:NUP50
uniprot id: F6YDF5
names: Subcellular Location Annotation
messages: nuclear pore complex

9544:ALKBH6
gene id: 9544:ALKBH6
uniprot id: F6X7J1
names: Similarity
messages: Belongs to the alkB family.

9544:CDC42EP3
gene id: 9544:CDC42EP3
uniprot id: A0A8J8XCE8
uniprot id: F6PS82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9544:HOXB9
gene id: 9544:HOXB9
uniprot id: A0A5F7ZVY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9544:GSTZ1
gene id: 9544:GSTZ1
uniprot id: F6PW84
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9544:MEPCE
gene id: 9544:MEPCE
uniprot id: H9Z0G3
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9544:AQP6
gene id: 9544:AQP6
uniprot id: A0A1D5R9F2
uniprot id: A0A5F8AQI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9544:RHCE
gene id: 9544:RHCE
uniprot id: Q28849
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
messages: Membrane

9544:MCM2
gene id: 9544:MCM2
uniprot id: A0A5K1URQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9544:AKAP8
gene id: 9544:AKAP8
uniprot id: F7DSP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKAP95 family.
messages: Nucleus matrix

9544:MARK2
gene id: 9544:MARK2
uniprot id: F6TA28
uniprot id: H9FR03
uniprot id: H9FR04
uniprot id: H9Z659
uniprot id: I0FPU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9544:CBS
gene id: 9544:CBS
uniprot id: A0A5K1U2N5
uniprot id: A0A8J8XBE8
uniprot id: G7MMI9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

9544:HSDL2
gene id: 9544:HSDL2
uniprot id: A0A8J8XYT1
uniprot id: G7NEH8
names: Subcellular Location Annotation
messages: Peroxisome

9544:STX4
gene id: 9544:STX4
uniprot id: A0A8J8Y4H7
uniprot id: G7NQX9
names: Similarity
messages: Belongs to the syntaxin family.

9544:TRIM62
gene id: 9544:TRIM62
uniprot id: F6WUS0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:DDX3Y
gene id: 9544:DDX3Y
uniprot id: I0FW06
names: Similarity
messages: Belongs to the DEAD box helicase family.

9544:OR51E2
gene id: 9544:OR51E2
uniprot id: F6ZU41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:NMI
gene id: 9544:NMI
uniprot id: A0A8J8YIA1
uniprot id: I0FJN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9544:PROC
gene id: 9544:PROC
uniprot id: A0A1D5QSH6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:DESI1
gene id: 9544:DESI1
uniprot id: A0A8J8YFG0
uniprot id: G7N3Z4
names: Similarity
messages: Belongs to the DeSI family.

9544:SBK2
gene id: 9544:SBK2
uniprot id: A0A8J8Y010
uniprot id: G7NNU7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:GNG11
gene id: 9544:GNG11
uniprot id: A0A8J8XW29
uniprot id: G7MLV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:PDS5B
gene id: 9544:PDS5B
uniprot id: A0A5F8AJT7
uniprot id: F7EQ66
uniprot id: H9Z6N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDS5 family.
messages: Nucleus

9544:SAA4
gene id: 9544:SAA4
uniprot id: A0A8J8YJY9
uniprot id: F6V9Q5
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9544:SNX18
gene id: 9544:SNX18
uniprot id: I2CUY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9544:OAT
gene id: 9544:OAT
uniprot id: A0A5F7ZD93
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9544:VPS18
gene id: 9544:VPS18
uniprot id: A0A8J8YEV3
uniprot id: F7G761
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9544:NXPH1
gene id: 9544:NXPH1
uniprot id: A0A8J8XJZ9
uniprot id: G7MLT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9544:PCSK2
gene id: 9544:PCSK2
uniprot id: F7GNE5
names: Similarity
messages: Belongs to the peptidase S8 family.

9544:LOC702864
gene id: 9544:LOC702864
uniprot id: A0A1D5RIM1
names: Similarity
messages: Belongs to the pro/parathymosin family.

9544:LPAR1
gene id: 9544:LPAR1
uniprot id: F7EZM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9544:ANXA3
gene id: 9544:ANXA3
uniprot id: A0A8J8XX57
uniprot id: G7MSZ8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9544:TMEM43
gene id: 9544:TMEM43
uniprot id: F7DGH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

9544:FGFR3
gene id: 9544:FGFR3
uniprot id: F7FZR9
uniprot id: F7FZS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9544:IPO11
gene id: 9544:IPO11
uniprot id: F7HC21
names: Subcellular Location Annotation
messages: Cytoplasm

9544:LOC699317
gene id: 9544:LOC699317
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:ZNF280D
gene id: 9544:ZNF280D
uniprot id: F7E177
uniprot id: F7E1I0
uniprot id: F7GSE2
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9544:STEAP1
gene id: 9544:STEAP1
uniprot id: F6PLK4
names: Subcellular Location Annotation
messages: Membrane

9544:LOC721435
gene id: 9544:LOC721435
uniprot id: F7GSU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:NTF4
gene id: 9544:NTF4
uniprot id: F7APK7
names: Similarity
messages: Belongs to the NGF-beta family.

9544:ALKBH2
gene id: 9544:ALKBH2
uniprot id: A0A5F8A7F8
uniprot id: A0A8J8XPX2
names: Similarity
messages: Belongs to the alkB family.

9544:CALHM2
gene id: 9544:CALHM2
uniprot id: A0A8J8XP61
uniprot id: F7EXA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9544:MRPL54
gene id: 9544:MRPL54
uniprot id: I2CY71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9544:TSSK2
gene id: 9544:TSSK2
uniprot id: F7H4I7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:GRPEL1
gene id: 9544:GRPEL1
uniprot id: F6PNE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9544:KRT222
gene id: 9544:KRT222
uniprot id: F6XQM6
names: Similarity
messages: Belongs to the intermediate filament family.

9544:KMO
gene id: 9544:KMO
uniprot id: A0A8J8YEK2
uniprot id: F6SV05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane

9544:VXN
gene id: 9544:VXN
uniprot id: A0A5K1VD68
uniprot id: A0A8J8XYA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vexin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus

9544:NR5A1
gene id: 9544:NR5A1
uniprot id: A0A5K1UJF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9544:PHACTR1
gene id: 9544:PHACTR1
uniprot id: F7GDH6
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9544:LOC704750
gene id: 9544:LOC704750
uniprot id: F6XZ76
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:IGF1
gene id: 9544:IGF1
uniprot id: A0A1D5Q6C0
uniprot id: F6W003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9544:MVB12B
gene id: 9544:MVB12B
uniprot id: A0A5K1UCN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:BRS3
gene id: 9544:BRS3
uniprot id: G7NRP5
uniprot id: Q6H2Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane
messages: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9544:NKX2-2
gene id: 9544:NKX2-2
uniprot id: A0A8J8XIN4
uniprot id: F7HHQ2
names: Subcellular Location Annotation
messages: Nucleus

9544:B3GALNT1
gene id: 9544:B3GALNT1
uniprot id: A0A8J8XUB5
uniprot id: F6UCJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:PNPLA6
gene id: 9544:PNPLA6
uniprot id: H9FP30
uniprot id: H9FP31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ALKBH7
gene id: 9544:ALKBH7
uniprot id: H9G0N4
names: Similarity
messages: Belongs to the alkB family.

9544:ING4
gene id: 9544:ING4
uniprot id: A0A1D5QYV2
uniprot id: A0A1D5R9G0
uniprot id: H9FVA2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9544:CRB1
gene id: 9544:CRB1
uniprot id: F7FIC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TGFB3
gene id: 9544:TGFB3
uniprot id: A0A8J8XIW7
uniprot id: F7HDK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9544:CLDN24
gene id: 9544:CLDN24
uniprot id: F7HH30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:ADGRG1
gene id: 9544:ADGRG1
uniprot id: A0A5F7ZJI8
uniprot id: A0A8J8XIN0
uniprot id: G7NPV1
uniprot id: Q50DM8
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADGRG1 NT is proposed to inhibit receptor signaling; its interactions with extracellular ligands and /or homophilic ADGRG1 NT interactions may relieve the inhibition. Following ligand binding to the N-terminal fragment, the N-terminal fragment is released from the seven-transmembrane C-terminal fragment to unveil a new N-terminal stalk, which then stimulates G-protein-dependent signaling activity. The N-terminal stalk has also been shown to be dispensable for at least some G-protein-dependent signaling.
messages: Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Shedding to yield the secreted ADGRG1 N-terminal fragment seems to involve metalloprotease(s).
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment (ADGRG1 NT) and the membrane-bound C-terminal fragment (ADGRG1-CT) predominantly remain associated and non-covalently linked. ADGRG1 NT self-associates in a trans-trans manner; the homophilic interaction enhances receptor signaling. ADGRG1-CT interacts with ARRB2; the interaction is impaired by ADGRG1 NT. Interacts with TGM2; TGM2 probably is not a ADGRG1 ligand and the interaction is reported controversial. Part of a GPCR-tetraspanin complex at least consisting of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of ADGRG1 with GNA11. Interacts with heparin; leading to the reduction of ADGRG1 shedding. Interacts with COL3A1 (By similarity).
messages: Membrane
messages: Membrane raft
messages: N-glycosylated. Contains sialic acid residues.
messages: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays an essential role in testis development (By similarity). Plays a critical role in tumourigenesis.
messages: Secreted
messages: Ubiquitinated. Undergoes polyubiquitination upon activation.

9544:TRMT2A
gene id: 9544:TRMT2A
uniprot id: H9FSY6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SRFBP1
gene id: 9544:SRFBP1
uniprot id: H9Z3N7
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9544:F7
gene id: 9544:F7
uniprot id: A0N0C5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:STXBP5L
gene id: 9544:STXBP5L
uniprot id: H9EUF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9544:HNRNPH1
gene id: 9544:HNRNPH1
uniprot id: A0A1D5Q1E5
uniprot id: A0A1D5QN82
uniprot id: F7G3L4
names: Subcellular Location Annotation
messages: nucleoplasm

9544:DGKE
gene id: 9544:DGKE
uniprot id: A0A8J8XNZ8
uniprot id: G7NHQ2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9544:GLCE
gene id: 9544:GLCE
uniprot id: A0A8J8XXX4
uniprot id: F7FIG3
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9544:ADAM28
gene id: 9544:ADAM28
uniprot id: F7GJP4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:PTGDR
gene id: 9544:PTGDR
uniprot id: F7HTJ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:TIGD6
gene id: 9544:TIGD6
uniprot id: F7BTK2
names: Subcellular Location Annotation
messages: Nucleus

9544:ABCG8
gene id: 9544:ABCG8
uniprot id: A0A5F8A138
uniprot id: A0A8J8YK29
uniprot id: F7H0X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9544:ENPP2
gene id: 9544:ENPP2
uniprot id: G7N009
uniprot id: I0FJB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9544:LYZL4
gene id: 9544:LYZL4
uniprot id: A0A8J8YLG2
uniprot id: F6WRF5
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

9544:FNIP1
gene id: 9544:FNIP1
uniprot id: F7HR04
uniprot id: H9G296
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9544:LOC706824
gene id: 9544:LOC706824
uniprot id: F6TKB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CNKSR1
gene id: 9544:CNKSR1
uniprot id: F7FZW3
names: Similarity
messages: Belongs to the CNKSR family.

9544:ATP5MG
gene id: 9544:ATP5MG
uniprot id: F6WC35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9544:SMIM15
gene id: 9544:SMIM15
uniprot id: F7END3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9544:SPTBN2
gene id: 9544:SPTBN2
uniprot id: A0A5K1UNR3
names: Similarity
messages: Belongs to the spectrin family.

9544:SOX14
gene id: 9544:SOX14
uniprot id: F7HQE3
names: Subcellular Location Annotation
messages: Nucleus

9544:CX3CR1
gene id: 9544:CX3CR1
uniprot id: H9EX48
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9544:ANAPC4
gene id: 9544:ANAPC4
uniprot id: H9ETG5
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

9544:LOC100430845
gene id: 9544:LOC100430845
uniprot id: G7MWD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ACP7
gene id: 9544:ACP7
uniprot id: A0A8J8YHF5
uniprot id: G7NNK0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9544:NFIL3
gene id: 9544:NFIL3
uniprot id: A0A8J8Y2L5
uniprot id: F7DIW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9544:SARM1
gene id: 9544:SARM1
uniprot id: F6UL84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARM1 family.
messages: axon

9544:MYO18A
gene id: 9544:MYO18A
uniprot id: H9ETW9
uniprot id: H9ETY4
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NDUFB2
gene id: 9544:NDUFB2
uniprot id: G7MMP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:MED11
gene id: 9544:MED11
uniprot id: A0A8J8XBM4
uniprot id: F7CJM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:AP3S1
gene id: 9544:AP3S1
uniprot id: A0A5F8A106
uniprot id: F6QF98
uniprot id: F7CIN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9544:NANOG
gene id: 9544:NANOG
uniprot id: F7GQZ2
names: Subcellular Location Annotation
messages: Nucleus

9544:TTC39A
gene id: 9544:TTC39A
uniprot id: F6RY03
names: Similarity
messages: Belongs to the TTC39 family.

9544:CLDN6
gene id: 9544:CLDN6
uniprot id: F7AWZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:ACO1
gene id: 9544:ACO1
uniprot id: A0A5F8AQZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

9544:REEP5
gene id: 9544:REEP5
uniprot id: A0A5F8AEF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9544:FGD6
gene id: 9544:FGD6
uniprot id: A0A5F8AD44
names: Subcellular Location Annotation
messages: cytoskeleton

9544:RFTN1
gene id: 9544:RFTN1
uniprot id: A0A8J8XTP8
uniprot id: I2CT62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9544:MCOLN2
gene id: 9544:MCOLN2
uniprot id: F6S280
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9544:DDX50
gene id: 9544:DDX50
uniprot id: A0A1D5QBU0
uniprot id: F6SQG1
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9544:USP33
gene id: 9544:USP33
uniprot id: A0A5K1USX4
uniprot id: F7HF92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9544:ENTPD3
gene id: 9544:ENTPD3
uniprot id: A0A5F7ZPG7
uniprot id: A0A8J8XJ60
uniprot id: F6XK13
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9544:FLCN
gene id: 9544:FLCN
uniprot id: H9ERY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9544:IL1RAPL1
gene id: 9544:IL1RAPL1
uniprot id: F7G3P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

9544:CEP19
gene id: 9544:CEP19
uniprot id: A0A8J8XBW7
uniprot id: F7FWC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9544:S100A6
gene id: 9544:S100A6
uniprot id: A0A8J8YFR0
uniprot id: F7DI51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
messages: Nucleus envelope

9544:ASB2
gene id: 9544:ASB2
uniprot id: F7EA98
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:MRPL2
gene id: 9544:MRPL2
uniprot id: F7G0Y5
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9544:VEGFC
gene id: 9544:VEGFC
uniprot id: B6EBK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9544:ARHGEF2
gene id: 9544:ARHGEF2
uniprot id: H9YUW1
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

9544:SLC35A1
gene id: 9544:SLC35A1
uniprot id: F7GAL6
uniprot id: I0FNI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:SELENOW
gene id: 9544:SELENOW
uniprot id: P63303
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SelWTH family. Selenoprotein W subfamily.
messages: Cytoplasm
messages: Highest levels detected in skeletal muscle, tongue, heart and brain. Expressed at significantly higher levels in female skeletal muscle than in male and at slightly higher levels in female cardiac muscle than in male (at protein level). Also detected at low levels in liver.
messages: Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90.
messages: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

9544:RNF112
gene id: 9544:RNF112
uniprot id: F6UR67
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9544:DDX54
gene id: 9544:DDX54
uniprot id: F7ET79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

9544:VAMP8
gene id: 9544:VAMP8
uniprot id: F6ZVQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9544:PIAS4
gene id: 9544:PIAS4
uniprot id: A0A1D5QIZ9
uniprot id: H9Z9X4
names: Similarity
messages: Belongs to the PIAS family.

9544:EPHA1
gene id: 9544:EPHA1
uniprot id: A0A5F8ANL5
names: Subcellular Location Annotation
messages: Membrane

9544:PSMD5
gene id: 9544:PSMD5
uniprot id: A0A8J8YEV0
uniprot id: G7NG21
uniprot id: H9FXG7
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9544:FAM133B
gene id: 9544:FAM133B
uniprot id: H9FSI0
names: Similarity
messages: Belongs to the FAM133 family.

9544:DGKG
gene id: 9544:DGKG
uniprot id: F6RTS2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9544:HDAC2
gene id: 9544:HDAC2
uniprot id: H9EPU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9544:MDH1B
gene id: 9544:MDH1B
uniprot id: F7AU42
uniprot id: G7N8R4
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9544:PTGES2
gene id: 9544:PTGES2
uniprot id: F7HPE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

9544:OPA1
gene id: 9544:OPA1
uniprot id: F6Y1R3
uniprot id: I2CT67
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9544:DHDH
gene id: 9544:DHDH
uniprot id: H9EXM3
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9544:GK
gene id: 9544:GK
uniprot id: A0A1D5QW52
uniprot id: H9FSZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9544:OST4
gene id: 9544:OST4
uniprot id: I2CYE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:LIPK
gene id: 9544:LIPK
uniprot id: F7BWV6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9544:HOXA11
gene id: 9544:HOXA11
uniprot id: A0A5F7ZF85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9544:DAPK3
gene id: 9544:DAPK3
uniprot id: A0A8J8YA95
uniprot id: I0FPJ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:FKBP4
gene id: 9544:FKBP4
uniprot id: H9ERN7
names: Subcellular Location Annotation
messages: Mitochondrion
messages: cytoskeleton
messages: cytosol

9544:IMP3
gene id: 9544:IMP3
uniprot id: F7GL33
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9544:CREBBP
gene id: 9544:CREBBP
uniprot id: A0A5F7ZKK8
uniprot id: A0A5F8ARC8
names: Subcellular Location Annotation
messages: Cytoplasm

9544:ADIPOR1
gene id: 9544:ADIPOR1
uniprot id: F7F197
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9544:MIS18A
gene id: 9544:MIS18A
uniprot id: H9FVZ5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9544:TIMM10
gene id: 9544:TIMM10
uniprot id: F7BG44
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9544:CD200R1
gene id: 9544:CD200R1
uniprot id: A0A075M976
names: Similarity
messages: Belongs to the CD200R family.

9544:TPM3
gene id: 9544:TPM3
uniprot id: A0A1D5QKL3
uniprot id: A0A5K1UXI5
uniprot id: A0A5K1VBZ1
uniprot id: F6VQX6
uniprot id: H9EN00
uniprot id: H9EN02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9544:ATP6V0D2
gene id: 9544:ATP6V0D2
uniprot id: A0A8J8XJ67
uniprot id: F7GTJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9544:CCR5
gene id: 9544:CCR5
uniprot id: A0A5F8AE97
uniprot id: A0A8J8XUT3
uniprot id: P61813
uniprot id: Q09GT7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis.
messages: O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
messages: Palmitoylation in the C-terminal is important for cell surface expression.
messages: Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
messages: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity).

9544:TMEM91
gene id: 9544:TMEM91
uniprot id: F6Z1E1
uniprot id: H9EQY1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:ACADS
gene id: 9544:ACADS
uniprot id: A0A8J8XRE8
uniprot id: H9ESN4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9544:CSF2
gene id: 9544:CSF2
uniprot id: A0A8J8XUW7
uniprot id: Q9GL44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9544:SLC7A10
gene id: 9544:SLC7A10
uniprot id: F6WMI1
uniprot id: I0FTG8
names: Subcellular Location Annotation
messages: Membrane

9544:LOC709451
gene id: 9544:LOC709451
uniprot id: A0A5F8ADU9
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:VCAN
gene id: 9544:VCAN
uniprot id: A0A5F7ZQ13
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:TAF5
gene id: 9544:TAF5
uniprot id: F7C0P5
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9544:FCF1
gene id: 9544:FCF1
uniprot id: H9FV66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9544:HRH2
gene id: 9544:HRH2
uniprot id: I2CTQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:HOXD12
gene id: 9544:HOXD12
uniprot id: F7GS07
names: Subcellular Location Annotation
messages: Nucleus

9544:FGF23
gene id: 9544:FGF23
uniprot id: A0A8J8Y3W7
uniprot id: F7FUS8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:LUC7L
gene id: 9544:LUC7L
uniprot id: A0A8J8XJU2
uniprot id: G7NQC4
uniprot id: H9ZB27
names: Similarity
messages: Belongs to the Luc7 family.

9544:EPN1
gene id: 9544:EPN1
uniprot id: G7NNV5
uniprot id: I2CTL0
names: Similarity
messages: Belongs to the epsin family.

9544:BRAF
gene id: 9544:BRAF
uniprot id: A0A1D5Q9W4
uniprot id: A0A5F8A7V3
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9544:C8B
gene id: 9544:C8B
uniprot id: A0A1D5RJJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:MGST1
gene id: 9544:MGST1
uniprot id: A0A1D5RL31
uniprot id: A0A8J8YPG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9544:SYNJ2
gene id: 9544:SYNJ2
uniprot id: F7DI71
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9544:LOC704664
gene id: 9544:LOC704664
uniprot id: A0A1D5QW91
uniprot id: A0A8J8YRZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:LOC704780
gene id: 9544:LOC704780
uniprot id: A0A5F8AS90
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:ZNF706
gene id: 9544:ZNF706
uniprot id: A0A8J8XW13
uniprot id: F7E1G3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:DSC3
gene id: 9544:DSC3
uniprot id: F7DB50
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9544:RPLP1
gene id: 9544:RPLP1
uniprot id: A0A8J8YGC0
uniprot id: F6TQ53
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9544:DKK2
gene id: 9544:DKK2
uniprot id: A0A8J8YAL3
uniprot id: F7GS28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9544:TMED5
gene id: 9544:TMED5
uniprot id: A0A8J8XHE2
uniprot id: F7CTP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9544:KRT13
gene id: 9544:KRT13
uniprot id: A0A1D5Q3N1
names: Similarity
messages: Belongs to the intermediate filament family.

9544:TMEM178B
gene id: 9544:TMEM178B
uniprot id: A0A1D5RKN8
names: Similarity
messages: Belongs to the TMEM178 family.

9544:SMAD2
gene id: 9544:SMAD2
uniprot id: A0A8J8Y228
uniprot id: F7CIW0
uniprot id: F7CP27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9544:UBE2G1
gene id: 9544:UBE2G1
uniprot id: H9FZA3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:ETF1
gene id: 9544:ETF1
uniprot id: F7CTK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9544:KCTD21
gene id: 9544:KCTD21
uniprot id: A0A8J8XHI3
uniprot id: F7HK74
names: Subcellular Location Annotation
messages: Cell membrane

9544:ADGRF5
gene id: 9544:ADGRF5
uniprot id: A0A5K1UTH2
uniprot id: F6TIA3
uniprot id: F7GTW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9544:CAMTA2
gene id: 9544:CAMTA2
uniprot id: A0A5F7ZAR0
uniprot id: F7HPI4
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

9544:TMEM167B
gene id: 9544:TMEM167B
uniprot id: H9EQ41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:HIST1H2AK
gene id: 9544:HIST1H2AK
uniprot id: A0A1D5QW91
uniprot id: A0A8J8YRZ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:HNRNPAB
gene id: 9544:HNRNPAB
uniprot id: H9YVR7
uniprot id: I0FHG3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:CBLB
gene id: 9544:CBLB
uniprot id: A0A5F8ACF3
uniprot id: F6T053
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9544:FBLN5
gene id: 9544:FBLN5
uniprot id: A0A1D5RJX9
uniprot id: F6V301
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SLC12A6
gene id: 9544:SLC12A6
uniprot id: A0A8J8YR62
uniprot id: F7H2L1
uniprot id: H9YWV0
uniprot id: I0FI98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9544:SLC7A11
gene id: 9544:SLC7A11
uniprot id: A0A5F8AAV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9544:UTP6
gene id: 9544:UTP6
uniprot id: A0A8J8YPM7
uniprot id: F6U7V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

9544:IL36A
gene id: 9544:IL36A
uniprot id: F6SRM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9544:USP27X
gene id: 9544:USP27X
uniprot id: H9EQI3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:PWWP3B
gene id: 9544:PWWP3B
uniprot id: F7EH17
names: Similarity
messages: Belongs to the PWWP3A family.

9544:FAM131C
gene id: 9544:FAM131C
uniprot id: A0A5F8A9R5
names: Similarity
messages: Belongs to the FAM131 family.

9544:TOP2B
gene id: 9544:TOP2B
uniprot id: I2CT72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9544:RBP4
gene id: 9544:RBP4
uniprot id: H9FY19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Secreted

9544:BIRC3
gene id: 9544:BIRC3
uniprot id: A0A5F8A395
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9544:CD6
gene id: 9544:CD6
uniprot id: H9ZFC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SLC7A8
gene id: 9544:SLC7A8
uniprot id: A0A8J8Y8U8
uniprot id: F7CUB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9544:SERPINI1
gene id: 9544:SERPINI1
uniprot id: A0A8J8XMG4
uniprot id: F6V360
names: Similarity
messages: Belongs to the serpin family.

9544:ITPR1
gene id: 9544:ITPR1
uniprot id: F7FEF3
uniprot id: F7FEK8
uniprot id: H9FU38
uniprot id: H9FU40
uniprot id: H9YVN2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9544:DAXX
gene id: 9544:DAXX
uniprot id: I0FPK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

9544:POLR1B
gene id: 9544:POLR1B
uniprot id: F7A8N8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9544:PAQR8
gene id: 9544:PAQR8
uniprot id: A0A8J8XX02
uniprot id: F7FLJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9544:UBE2N
gene id: 9544:UBE2N
uniprot id: H9FZA7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:NKIRAS1
gene id: 9544:NKIRAS1
uniprot id: A0A8J8Y6V6
uniprot id: G7MJY0
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9544:RIOX1
gene id: 9544:RIOX1
uniprot id: F6YUZ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.

9544:CAPN1
gene id: 9544:CAPN1
uniprot id: H9G0C4
names: Similarity
messages: Belongs to the peptidase C2 family.

9544:OR4F6
gene id: 9544:OR4F6
uniprot id: A0A8J8YB81
uniprot id: F7GTD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:METAP2
gene id: 9544:METAP2
uniprot id: H9Z4P2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9544:PPP1CB
gene id: 9544:PPP1CB
uniprot id: H9FWD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9544:LOC704989
gene id: 9544:LOC704989
uniprot id: A0A5F8AQ96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9544:EPAS1
gene id: 9544:EPAS1
uniprot id: A0A8J8YN14
uniprot id: G7NA01
names: Subcellular Location Annotation
messages: Nucleus speckle

9544:SP4
gene id: 9544:SP4
uniprot id: F7F0R7
names: Subcellular Location Annotation
messages: Nucleus

9544:GTF2A1
gene id: 9544:GTF2A1
uniprot id: I0FLS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9544:LOC106992283
gene id: 9544:LOC106992283
uniprot id: A0A8J8XJG7
uniprot id: F7GAF4
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9544:MFSD14B
gene id: 9544:MFSD14B
uniprot id: F7GRF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9544:MAP3K12
gene id: 9544:MAP3K12
uniprot id: A0A8J8XVU7
uniprot id: H9FZL0
uniprot id: H9FZL1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9544:DCN
gene id: 9544:DCN
uniprot id: F6PRM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

9544:MAGOHB
gene id: 9544:MAGOHB
uniprot id: F7C465
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9544:GRM3
gene id: 9544:GRM3
uniprot id: A0A8J8Y9X5
uniprot id: F6YNZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9544:TTC9B
gene id: 9544:TTC9B
uniprot id: I2CYH7
names: Similarity
messages: Belongs to the TTC9 family.

9544:RNF141
gene id: 9544:RNF141
uniprot id: A0A8J8YDJ8
uniprot id: F7AVV4
names: Function
messages: May be involved in spermatogenesis.

9544:P2RX4
gene id: 9544:P2RX4
uniprot id: F7DXP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9544:CDKN1B
gene id: 9544:CDKN1B
uniprot id: A0A1D5RC88
uniprot id: A0A8J8YE36
names: Similarity
messages: Belongs to the CDI family.

9544:FITM2
gene id: 9544:FITM2
uniprot id: A0A8J8Y5E9
uniprot id: F7HI34
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:STRN4
gene id: 9544:STRN4
uniprot id: F7ES64
uniprot id: H9FTJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9544:GCH1
gene id: 9544:GCH1
uniprot id: F6ZD19
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

9544:QRFP
gene id: 9544:QRFP
uniprot id: A0A8J8XR83
uniprot id: F7EGY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFamide neuropeptide family.
messages: Secreted

9544:CACTIN
gene id: 9544:CACTIN
uniprot id: F6YGQ7
uniprot id: H9ZBV6
names: Similarity
messages: Belongs to the CACTIN family.

9544:PDK1
gene id: 9544:PDK1
uniprot id: F7GNV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9544:NOC3L
gene id: 9544:NOC3L
uniprot id: F7GTD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

9544:TMEM211
gene id: 9544:TMEM211
uniprot id: F6SSC5
names: Subcellular Location Annotation
messages: Membrane

9544:FAM20A
gene id: 9544:FAM20A
uniprot id: A0A5F7ZMN7
uniprot id: F6WFV9
names: Similarity
messages: Belongs to the FAM20 family.

9544:RBBP8
gene id: 9544:RBBP8
uniprot id: H9ZBY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

9544:BLMH
gene id: 9544:BLMH
uniprot id: H9ER37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9544:DMPK
gene id: 9544:DMPK
uniprot id: F7GBZ8
uniprot id: H9FQT3
uniprot id: H9FQT4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.

9544:RPL10L
gene id: 9544:RPL10L
uniprot id: A0A8J8Y6K7
uniprot id: G7MXP3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9544:B4GALT7
gene id: 9544:B4GALT7
uniprot id: H9Z4X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9544:C5AR2
gene id: 9544:C5AR2
uniprot id: F7H5Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9544:AGAP1
gene id: 9544:AGAP1
uniprot id: H9EU55
uniprot id: H9FPN7
uniprot id: I0FFX0
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9544:SLC35A2
gene id: 9544:SLC35A2
uniprot id: F6S505
uniprot id: H9ERT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:CRP
gene id: 9544:CRP
uniprot id: G7ME52
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:FZD7
gene id: 9544:FZD7
uniprot id: A0A1D5Q0F6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CCR4
gene id: 9544:CCR4
uniprot id: A0A8J8XQY5
uniprot id: F7GUA3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:SLC50A1
gene id: 9544:SLC50A1
uniprot id: A0A8J8XLQ7
uniprot id: F6TTJ4
uniprot id: F6X7V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9544:PTPN22
gene id: 9544:PTPN22
uniprot id: H9YVP8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

9544:FOPNL
gene id: 9544:FOPNL
uniprot id: A0A1D5Q8M3
uniprot id: A0A8J8XGQ0
uniprot id: G7NPQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9544:PEX2
gene id: 9544:PEX2
uniprot id: A0A5F7ZH32
uniprot id: A0A8J8YH91
uniprot id: G7MZL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9544:TM4SF4
gene id: 9544:TM4SF4
uniprot id: A0A1D5QM45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9544:SIDT1
gene id: 9544:SIDT1
uniprot id: F6YGU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9544:NRP2
gene id: 9544:NRP2
uniprot id: F7G9V7
uniprot id: F7G9W1
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:GNRHR2
gene id: 9544:GNRHR2
uniprot id: Q95JG1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Phosphorylated on the C-terminal cytoplasmic tail.
messages: Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9544:AHSA2P
gene id: 9544:AHSA2P
uniprot id: G7NA51
names: Similarity
messages: Belongs to the AHA1 family.

9544:CAMK1G
gene id: 9544:CAMK1G
uniprot id: A0A8J8Y161
uniprot id: G7MEP2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:NECTIN3
gene id: 9544:NECTIN3
uniprot id: A0A1D5QFJ5
names: Similarity
messages: Belongs to the nectin family.

9544:LOC106994757
gene id: 9544:LOC106994757
uniprot id: A0A7R8C332
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9544:PTMS
gene id: 9544:PTMS
uniprot id: H9FXQ3
names: Similarity
messages: Belongs to the pro/parathymosin family.

9544:LOC718452
gene id: 9544:LOC718452
uniprot id: A0A5F7ZH52
names: Subcellular Location Annotation
messages: Membrane

9544:ACTN3
gene id: 9544:ACTN3
uniprot id: F7HER2
names: Similarity
messages: Belongs to the alpha-actinin family.

9544:STAT5A
gene id: 9544:STAT5A
uniprot id: A0A1D5QPR1
uniprot id: F7G8V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9544:RPLP2
gene id: 9544:RPLP2
uniprot id: F7BM66
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9544:HMGCS2
gene id: 9544:HMGCS2
uniprot id: A0A1D5QMU4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9544:LOC717274
gene id: 9544:LOC717274
uniprot id: F6USN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:RANBP6
gene id: 9544:RANBP6
uniprot id: H9FSX5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:RAD1
gene id: 9544:RAD1
uniprot id: F7A5K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9544:CTNS
gene id: 9544:CTNS
uniprot id: A0A8J8XW65
uniprot id: F7DR72
uniprot id: I2CW32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9544:TIMM17B
gene id: 9544:TIMM17B
uniprot id: A0A8J8YR20
uniprot id: H9EU53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9544:SH3BGRL2
gene id: 9544:SH3BGRL2
uniprot id: H9G0H1
names: Similarity
messages: Belongs to the SH3BGR family.

9544:GALNTL5
gene id: 9544:GALNTL5
uniprot id: F7F8Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

9544:CDC73
gene id: 9544:CDC73
uniprot id: A0A8J8Y1C8
uniprot id: G7MF09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

9544:KLC2
gene id: 9544:KLC2
uniprot id: F6YHS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9544:SHTN1
gene id: 9544:SHTN1
uniprot id: H9ERM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: Perikaryon
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9544:B4GALT3
gene id: 9544:B4GALT3
uniprot id: A0A8J8Y7L6
uniprot id: F6WU79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9544:GPR17
gene id: 9544:GPR17
uniprot id: F7HM53
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:S100A16
gene id: 9544:S100A16
uniprot id: H9Z3V3
names: Similarity
messages: Belongs to the S-100 family.

9544:SLC17A8
gene id: 9544:SLC17A8
uniprot id: F6UIA5
names: Subcellular Location Annotation
messages: Membrane

9544:TM9SF4
gene id: 9544:TM9SF4
uniprot id: F7CJR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9544:ASIC1
gene id: 9544:ASIC1
uniprot id: F7H4L2
names: Subcellular Location Annotation
messages: Membrane

9544:TAF6L
gene id: 9544:TAF6L
uniprot id: H9ESP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9544:ADHFE1
gene id: 9544:ADHFE1
uniprot id: F6T885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9544:IL2RG
gene id: 9544:IL2RG
uniprot id: A0A8J8XU62
uniprot id: Q38JL2
names: Subcellular Location Annotation
messages: Membrane

9544:GABRA2
gene id: 9544:GABRA2
uniprot id: A0A8J8Y551
uniprot id: G7MSU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9544:OR5A2
gene id: 9544:OR5A2
uniprot id: F7C209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ATP6V0E1
gene id: 9544:ATP6V0E1
uniprot id: A0A8J8XT11
uniprot id: H9ERW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9544:CD68
gene id: 9544:CD68
uniprot id: F6ZES3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9544:SLC16A5
gene id: 9544:SLC16A5
uniprot id: A0A8J8XR62
uniprot id: G7NGN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9544:CNOT2
gene id: 9544:CNOT2
uniprot id: A0A1D5Q7D4
uniprot id: A0A8J8XW57
uniprot id: F7BE69
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9544:ALDOC
gene id: 9544:ALDOC
uniprot id: A0A8J8Y737
uniprot id: G7NGJ8
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9544:LOC713091
gene id: 9544:LOC713091
uniprot id: F7HEJ6
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9544:MRPL20
gene id: 9544:MRPL20
uniprot id: A0A5F8A0J3
uniprot id: F7EZM8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9544:MON1A
gene id: 9544:MON1A
uniprot id: A0A1D5QTN8
uniprot id: A0A8J8YCQ1
uniprot id: G7ML79
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9544:MED23
gene id: 9544:MED23
uniprot id: A0A1D5QPU4
uniprot id: A0A1D5QXI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

9544:RIOX2
gene id: 9544:RIOX2
uniprot id: A0A8J8YET6
uniprot id: F7DPH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. MINA53 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.

9544:TASP1
gene id: 9544:TASP1
uniprot id: A0A8J8XLE2
uniprot id: G7N2Z7
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9544:RNASE6
gene id: 9544:RNASE6
uniprot id: A0A8J8XUK1
uniprot id: F7G6N3
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9544:EIF4G1
gene id: 9544:EIF4G1
uniprot id: F7GJF3
uniprot id: H9FQY6
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9544:DPH6
gene id: 9544:DPH6
uniprot id: H9G1H7
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9544:GINS2
gene id: 9544:GINS2
uniprot id: F7BZU2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9544:NAA60
gene id: 9544:NAA60
uniprot id: H9ET69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

9544:ABI2
gene id: 9544:ABI2
uniprot id: A0A1D5QAQ1
uniprot id: A0A1D5R9D2
uniprot id: F6YV31
uniprot id: F6YV41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9544:DYNC2H1
gene id: 9544:DYNC2H1
uniprot id: F7GFI1
uniprot id: F7HHK5
names: Similarity
messages: Belongs to the dynein heavy chain family.

9544:PRDM4
gene id: 9544:PRDM4
uniprot id: A0A1D5REV3
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

9544:ENO2
gene id: 9544:ENO2
uniprot id: A0A8J8YD48
uniprot id: F6X1V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9544:BET1
gene id: 9544:BET1
uniprot id: F6UL51
names: Subcellular Location Annotation
messages: Membrane

9544:RBM17
gene id: 9544:RBM17
uniprot id: A0A8J8YSQ0
uniprot id: F6UDK4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9544:PCSK1
gene id: 9544:PCSK1
uniprot id: H9FVB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9544:HINT1
gene id: 9544:HINT1
uniprot id: F6R248
names: Similarity
messages: Belongs to the HINT family.

9544:SLC9A3
gene id: 9544:SLC9A3
uniprot id: F7GVI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

9544:NONO
gene id: 9544:NONO
uniprot id: A0A5F7ZCD6
uniprot id: A0A8J8YAT5
uniprot id: G7NRV6
names: Subcellular Location Annotation
messages: Nucleus speckle

9544:CYP1B1
gene id: 9544:CYP1B1
uniprot id: H9Z5P7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:FAM234A
gene id: 9544:FAM234A
uniprot id: A0A8J8Y7W3
uniprot id: F6Y977
uniprot id: I0FGW2
names: Similarity
messages: Belongs to the FAM234 family.

9544:HOGA1
gene id: 9544:HOGA1
uniprot id: F7GG87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9544:TMEM201
gene id: 9544:TMEM201
uniprot id: I2CWL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

9544:HMX1
gene id: 9544:HMX1
uniprot id: A0A5F7ZR98
names: Subcellular Location Annotation
messages: Nucleus

9544:OSBPL1A
gene id: 9544:OSBPL1A
uniprot id: H9EM54
names: Similarity
messages: Belongs to the OSBP family.

9544:AOC1
gene id: 9544:AOC1
uniprot id: F6TU01
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9544:DPEP1
gene id: 9544:DPEP1
uniprot id: H9YZT9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9544:HEBP1
gene id: 9544:HEBP1
uniprot id: A0A8J8XJ98
uniprot id: F6UQB6
names: Similarity
messages: Belongs to the HEBP family.

9544:OR2A25
gene id: 9544:OR2A25
uniprot id: F6XL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:SH3GL3
gene id: 9544:SH3GL3
uniprot id: A0A5F7ZHJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9544:SUFU
gene id: 9544:SUFU
uniprot id: H9EP79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9544:C5H4orf27
gene id: 9544:C5H4orf27
uniprot id: A0A1D5RAN6
uniprot id: F6S3H7
names: Similarity
messages: Belongs to the HPF1 family.

9544:FOLR2
gene id: 9544:FOLR2
uniprot id: A0A8J8XNQ3
uniprot id: F7CR90
uniprot id: H9Z0D2
names: Similarity
messages: Belongs to the folate receptor family.

9544:RGMB
gene id: 9544:RGMB
uniprot id: I2CTQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9544:RBBP4
gene id: 9544:RBBP4
uniprot id: H9ZBY4
names: Subcellular Location Annotation
messages: Nucleus

9544:SMARCD1
gene id: 9544:SMARCD1
uniprot id: A0A1D5REM3
uniprot id: F7HTY2
names: Similarity
messages: Belongs to the SMARCD family.

9544:NEUROD2
gene id: 9544:NEUROD2
uniprot id: F7CUL4
names: Subcellular Location Annotation
messages: Nucleus

9544:TM6SF2
gene id: 9544:TM6SF2
uniprot id: F6UI24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

9544:CDCA8
gene id: 9544:CDCA8
uniprot id: A0A8J8YGZ0
uniprot id: F7CYE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9544:SPDYE4
gene id: 9544:SPDYE4
uniprot id: F6Z698
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9544:BRCA1
gene id: 9544:BRCA1
uniprot id: F7BG30
uniprot id: Q6J6I9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote degradation.
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1 (By similarity). Interacts with EXD2 (By similarity). Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme (By simila…
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.
messages: Nucleus
messages: Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-987 by CHEK2 regulates mitotic spindle assembly. Phosphorylation by AURKA regulates centrosomal microtubule nucleation.
messages: The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the phosphorylated pSXXF motif of ABRAXAS1, recruits BRCA1 at DNA damage sites.
messages: The RING-type zinc finger domain interacts with BAP1.

9544:SPDL1
gene id: 9544:SPDL1
uniprot id: H9EW97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9544:PRICKLE2
gene id: 9544:PRICKLE2
uniprot id: A0A8J8XED2
uniprot id: F7GCX1
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9544:NAPA
gene id: 9544:NAPA
uniprot id: A0A8J8YSE4
uniprot id: F6Z997
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9544:CD82
gene id: 9544:CD82
uniprot id: G7NDI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:HSD17B1
gene id: 9544:HSD17B1
uniprot id: Q1WNP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Favors the reduction of estrogens and androgens. Uses preferentially NADH.

9544:ADGRB2
gene id: 9544:ADGRB2
uniprot id: A0A1D5R177
uniprot id: F7FAA5
names: Subcellular Location Annotation
messages: Membrane

9544:CCNH
gene id: 9544:CCNH
uniprot id: A0A8J8YPU1
uniprot id: G7MV81
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9544:OR6X1
gene id: 9544:OR6X1
uniprot id: A0A8J8Y9J1
uniprot id: F7F452
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9544:RECQL
gene id: 9544:RECQL
uniprot id: A0A5F8A131
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9544:STAT6
gene id: 9544:STAT6
uniprot id: F6UMM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9544:NKAIN2
gene id: 9544:NKAIN2
uniprot id: A0A5K1U721
uniprot id: F6XKU1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:ITPKB
gene id: 9544:ITPKB
uniprot id: H9Z8N7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9544:GNG3
gene id: 9544:GNG3
uniprot id: A0A8J8XZF5
uniprot id: G7NCS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:OR4A47
gene id: 9544:OR4A47
uniprot id: F7FJU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PSMB5
gene id: 9544:PSMB5
uniprot id: A0A8J8XR90
uniprot id: G7MX33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9544:SLC7A3
gene id: 9544:SLC7A3
uniprot id: F7FKL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9544:DLD
gene id: 9544:DLD
uniprot id: A0A8J8XRG6
uniprot id: H9Z5Y2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9544:SLC6A12
gene id: 9544:SLC6A12
uniprot id: F7HP51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Lateral cell membrane
messages: Membrane

9544:GRM1
gene id: 9544:GRM1
uniprot id: A0A8J8YLZ4
uniprot id: I2CU04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9544:GPR3
gene id: 9544:GPR3
uniprot id: A0A8J8YLJ7
uniprot id: F7HFA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:SDR42E1
gene id: 9544:SDR42E1
uniprot id: F6UMT9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9544:CXCR2
gene id: 9544:CXCR2
uniprot id: Q8HZN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CSRNP3
gene id: 9544:CSRNP3
uniprot id: A0A8J8XE88
uniprot id: G7N875
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9544:TRIM21
gene id: 9544:TRIM21
uniprot id: F7C1A0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:ATP2C1
gene id: 9544:ATP2C1
uniprot id: H9FSY3
uniprot id: H9FSY4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:LOC699655
gene id: 9544:LOC699655
uniprot id: A0A8J8XFZ1
uniprot id: G7MMT7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9544:PRM1
gene id: 9544:PRM1
uniprot id: G7NPN0
uniprot id: Q9GJU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Testis.

9544:SIAH1
gene id: 9544:SIAH1
uniprot id: A0A5F7ZGZ6
uniprot id: A0A8J8YH02
uniprot id: F6T3K3
uniprot id: F6WEY4
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9544:GLDC
gene id: 9544:GLDC
uniprot id: F6PUG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9544:APOBEC3A
gene id: 9544:APOBEC3A
uniprot id: F6M3K4
names: Subcellular Location Annotation
messages: Cytoplasm

9544:PWWP3A
gene id: 9544:PWWP3A
uniprot id: A0A8J8YL14
uniprot id: G7NL48
names: Similarity
messages: Belongs to the PWWP3A family.

9544:GAD2
gene id: 9544:GAD2
uniprot id: A0A8J8XZF1
uniprot id: G7N1R9
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9544:TGFBR1
gene id: 9544:TGFBR1
uniprot id: F7H0K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9544:CCL21
gene id: 9544:CCL21
uniprot id: Q8HYP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).
messages: Monomer. Binds to CCR7. Interacts with PDPN; relocalizes PDPN to the basolateral membrane. Interacts with TNFAIP6 (via Link domain).
messages: Secreted

9544:SUSD4
gene id: 9544:SUSD4
uniprot id: F7DX72
uniprot id: F7G9N8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:GAB1
gene id: 9544:GAB1
uniprot id: A0A8J8YDH0
uniprot id: F6Q209
uniprot id: I0FQK0
names: Similarity
messages: Belongs to the GAB family.

9544:HEPH
gene id: 9544:HEPH
uniprot id: G7NRS5
names: Similarity
messages: Belongs to the multicopper oxidase family.

9544:PAQR3
gene id: 9544:PAQR3
uniprot id: F7GGW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9544:TSEN2
gene id: 9544:TSEN2
uniprot id: A0A5K1TVZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9544:SNX11
gene id: 9544:SNX11
uniprot id: A0A8J8YT32
uniprot id: F7BF03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9544:ART5
gene id: 9544:ART5
uniprot id: A0A5F7ZIN0
uniprot id: G7NE76
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9544:PARK7
gene id: 9544:PARK7
uniprot id: H9FPH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9544:CYorf15A
gene id: 9544:CYorf15A
uniprot id: B8YDZ9
names: Similarity
messages: Belongs to the taxilin family.

9544:KAT2A
gene id: 9544:KAT2A
uniprot id: H9FSV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9544:SCRN1
gene id: 9544:SCRN1
uniprot id: A0A5F7ZWV4
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9544:EHHADH
gene id: 9544:EHHADH
uniprot id: F7GFA8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9544:LOC702309
gene id: 9544:LOC702309
uniprot id: G7MEA1
uniprot id: I2CTM5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9544:SENP7
gene id: 9544:SENP7
uniprot id: A0A1D5QGC5
uniprot id: A0A5F7ZSH5
uniprot id: A0A5F8AJB7
uniprot id: F6WFK4
uniprot id: F6WFM3
names: Similarity
messages: Belongs to the peptidase C48 family.

9544:ARHGEF9
gene id: 9544:ARHGEF9
uniprot id: A0A1D5QVN2
uniprot id: H9EPM3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
messages: Cytoplasm
messages: Interacts with GPHN.
messages: Postsynaptic density

9544:PHKA1
gene id: 9544:PHKA1
uniprot id: H9YVJ6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9544:SNRPE
gene id: 9544:SNRPE
uniprot id: A0A8J8XC02
uniprot id: G7MEV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9544:KEG06 p11
gene id: 9544:KEG06_p11
uniprot id: I3W8K0
uniprot id: Q6IYH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9544:SLC52A3
gene id: 9544:SLC52A3
uniprot id: A0A8J8XDI6
uniprot id: F7F4Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9544:PPY
gene id: 9544:PPY
uniprot id: G7NIW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9544:MEA1
gene id: 9544:MEA1
uniprot id: A0A8J8YNH1
uniprot id: F7AP22
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

9544:MRPL22
gene id: 9544:MRPL22
uniprot id: G7MVQ7
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9544:TCEAL1
gene id: 9544:TCEAL1
uniprot id: A2D671
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity).
messages: Nucleus

9544:CYP3A5
gene id: 9544:CYP3A5
uniprot id: Q6GUQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:COQ10B
gene id: 9544:COQ10B
uniprot id: A0A8J8YDJ4
uniprot id: F7BGC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9544:GPR34
gene id: 9544:GPR34
uniprot id: F6ZED1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor.

9544:NPC1
gene id: 9544:NPC1
uniprot id: A0A5K1USA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9544:PIGO
gene id: 9544:PIGO
uniprot id: A0A5F7ZKI1
uniprot id: F7H2K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:YIPF4
gene id: 9544:YIPF4
uniprot id: A0A8J8Y3S4
uniprot id: G7N9T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:CDR2
gene id: 9544:CDR2
uniprot id: F7HT75
names: Similarity
messages: Belongs to the CDR2 family.

9544:MPP3
gene id: 9544:MPP3
uniprot id: F6ZCE9
names: Similarity
messages: Belongs to the MAGUK family.

9544:GRWD1
gene id: 9544:GRWD1
uniprot id: G7NNP9
names: Subcellular Location Annotation
messages: Nucleus

9544:GAS8
gene id: 9544:GAS8
uniprot id: H9FST4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum
messages: flagellum axoneme

9544:SLCO2A1
gene id: 9544:SLCO2A1
uniprot id: A0A1D5Q5B4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:MRPS26
gene id: 9544:MRPS26
uniprot id: F6TKV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9544:TMEM186
gene id: 9544:TMEM186
uniprot id: H9FSL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9544:LOC697943
gene id: 9544:LOC697943
uniprot id: A0A5F8A1L8
uniprot id: F6Z735
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9544:CLEC18A
gene id: 9544:CLEC18A
uniprot id: F6X9G0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:LOC703700
gene id: 9544:LOC703700
uniprot id: H9EQ74
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9544:CCM2
gene id: 9544:CCM2
uniprot id: A0A1D5Q714
uniprot id: A0A1D5QD55
uniprot id: H9G0F6
uniprot id: H9G0F7
uniprot id: H9G0F8
names: Similarity
messages: Belongs to the CCM2 family.

9544:VAT1
gene id: 9544:VAT1
uniprot id: Q3I1S1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9544:ICMT
gene id: 9544:ICMT
uniprot id: F7H607
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:SLC12A4
gene id: 9544:SLC12A4
uniprot id: H9ETV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9544:CHRM5
gene id: 9544:CHRM5
uniprot id: G7MWA0
uniprot id: P56490
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9544:ADGRG3
gene id: 9544:ADGRG3
uniprot id: G7NPV2
names: Subcellular Location Annotation
messages: Membrane

9544:MEF2D
gene id: 9544:MEF2D
uniprot id: F6VKY1
uniprot id: F6VKZ8
uniprot id: F6VLM2
names: Subcellular Location Annotation
messages: Nucleus

9544:ACAD8
gene id: 9544:ACAD8
uniprot id: A0A5F8AIA9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9544:RIC8B
gene id: 9544:RIC8B
uniprot id: A0A5F8ASZ2
uniprot id: A0A8J8YNX6
uniprot id: F7H8I7
uniprot id: G7N5D4
uniprot id: H9FWK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9544:ZFHX3
gene id: 9544:ZFHX3
uniprot id: A0A5F7ZI76
names: Subcellular Location Annotation
messages: Nucleus

9544:SEC24C
gene id: 9544:SEC24C
uniprot id: F7F6F3
uniprot id: H9G287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9544:MGAT5B
gene id: 9544:MGAT5B
uniprot id: G7NGZ1
uniprot id: H9FQB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:PTGER2
gene id: 9544:PTGER2
uniprot id: A0A8J8XGH0
uniprot id: F7HTJ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:CDYL2
gene id: 9544:CDYL2
uniprot id: A0A1D5RKF7
names: Subcellular Location Annotation
messages: Nucleus

9544:SPTSSA
gene id: 9544:SPTSSA
uniprot id: H9FQR5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ADH1A
gene id: 9544:ADH1A
uniprot id: P28469
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alcohol dehydrogenase. Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate.
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Dimer of identical or heterodimer of closely related subunits alpha, beta, or gamma that are encoded by genes ADH1A, ADH1B, and ADH1C, respectively.

9544:GNG12
gene id: 9544:GNG12
uniprot id: A0A8J8XIJ6
uniprot id: I0FMD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9544:NAB2
gene id: 9544:NAB2
uniprot id: F6UUT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9544:PPP4R3B
gene id: 9544:PPP4R3B
uniprot id: A0A5K1V8W7
uniprot id: H9ETK8
uniprot id: H9ETV2
uniprot id: H9FXJ6
uniprot id: H9ZBK0
names: Similarity
messages: Belongs to the SMEK family.

9544:STAC3
gene id: 9544:STAC3
uniprot id: A0A8J8Y188
uniprot id: F7DEB5
uniprot id: F7H7S2
names: Subcellular Location Annotation
messages: sarcolemma

9544:ELK3
gene id: 9544:ELK3
uniprot id: A0A8J8XJB0
uniprot id: F7F772
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:GPD1L
gene id: 9544:GPD1L
uniprot id: H9ET42
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9544:TTC19
gene id: 9544:TTC19
uniprot id: F7EVI2
names: Similarity
messages: Belongs to the TTC19 family.

9544:GABARAPL1
gene id: 9544:GABARAPL1
uniprot id: A0A8J8XLB0
uniprot id: F6WFV1
names: Similarity
messages: Belongs to the ATG8 family.

9544:YTHDC1
gene id: 9544:YTHDC1
uniprot id: A0A5K1UUP9
uniprot id: I2CYY0
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9544:NFE2
gene id: 9544:NFE2
uniprot id: A0A8J8XEC8
uniprot id: F7H4R2
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9544:YWHAQ
gene id: 9544:YWHAQ
uniprot id: F7DW30
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
messages: Belongs to the 14-3-3 family.

9544:MLN
gene id: 9544:MLN
uniprot id: O18811
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

9544:SLC30A10
gene id: 9544:SLC30A10
uniprot id: A0A8J8YMN9
uniprot id: F6ZX24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9544:ALOX12B
gene id: 9544:ALOX12B
uniprot id: F6WGW5
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:APOBEC3B
gene id: 9544:APOBEC3B
uniprot id: F6M3K5
names: Subcellular Location Annotation
messages: Cytoplasm

9544:RNASE1
gene id: 9544:RNASE1
uniprot id: G8F203
uniprot id: H9FY36
uniprot id: Q8SPN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pancreatic ribonuclease family.
messages: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity).
messages: Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein (By similarity).
messages: Secreted

9544:PPP1R1B
gene id: 9544:PPP1R1B
uniprot id: F7HE42
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9544:RPS6KA4
gene id: 9544:RPS6KA4
uniprot id: F6SDE0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9544:DTNBP1
gene id: 9544:DTNBP1
uniprot id: F6SN96
names: Similarity
messages: Belongs to the dysbindin family.

9544:GPSM2
gene id: 9544:GPSM2
uniprot id: A0A5F7ZC43
uniprot id: H9FTK2
names: Similarity
messages: Belongs to the GPSM family.

9544:KIN
gene id: 9544:KIN
uniprot id: A0A8J8XLH3
uniprot id: H9Z6J7
names: Similarity
messages: Belongs to the KIN17 family.

9544:H2AFX
gene id: 9544:H2AFX
uniprot id: A0A1D5Q5B3
uniprot id: A0A8J8Y7Z6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:FKTN
gene id: 9544:FKTN
uniprot id: A0A5F7ZUZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9544:LRP8
gene id: 9544:LRP8
uniprot id: F6SDB7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:UPF2
gene id: 9544:UPF2
uniprot id: A0A5K1V9Y6
names: Subcellular Location Annotation
messages: Cytoplasm

9544:CFAP300
gene id: 9544:CFAP300
uniprot id: F7FES7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9544:TMCC1
gene id: 9544:TMCC1
uniprot id: A0A8J8Y8G5
uniprot id: F7HEJ1
names: Similarity
messages: Belongs to the TEX28 family.

9544:DNAJB14
gene id: 9544:DNAJB14
uniprot id: H9EUC0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:GNB3
gene id: 9544:GNB3
uniprot id: A0A8J8YKJ1
uniprot id: F7CTP1
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9544:GRM2
gene id: 9544:GRM2
uniprot id: A0A8J8YHU3
uniprot id: F7H091
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9544:DLK1
gene id: 9544:DLK1
uniprot id: A0A5F8AFZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:VCAM1
gene id: 9544:VCAM1
uniprot id: A0A8J8YC78
uniprot id: F6W7X9
names: Subcellular Location Annotation
messages: Cell membrane

9544:LOC703224
gene id: 9544:LOC703224
uniprot id: F7HFM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9544:NOP56
gene id: 9544:NOP56
uniprot id: F6R553
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus
messages: nucleoplasm

9544:EIF2B2
gene id: 9544:EIF2B2
uniprot id: A0A8J8Y3L2
uniprot id: F7HB02
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9544:C11H12orf65
gene id: 9544:C11H12orf65
uniprot id: A0A1D5Q6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9544:NFE2L1
gene id: 9544:NFE2L1
uniprot id: F6T3Z4
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9544:SCRN3
gene id: 9544:SCRN3
uniprot id: A0A1D5QHT0
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9544:ETS1
gene id: 9544:ETS1
uniprot id: A0A1D5QXL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9544:EDNRB
gene id: 9544:EDNRB
uniprot id: F7BXI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ELK4
gene id: 9544:ELK4
uniprot id: A0A8J8XF46
uniprot id: F6XTS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:DCTN5
gene id: 9544:DCTN5
uniprot id: A0A8J8Y4A8
uniprot id: G7NQ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

9544:ATP6V1C1
gene id: 9544:ATP6V1C1
uniprot id: A0A1D5Q465
uniprot id: A0A8J8YM03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9544:GRM4
gene id: 9544:GRM4
uniprot id: A0A8J8XKE6
uniprot id: G7MRR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9544:GHSR
gene id: 9544:GHSR
uniprot id: F6Z4B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:C3
gene id: 9544:C3
uniprot id: F7EV32
names: Function
names: Subcellular Location Annotation
messages: Acts as a chemoattractant for neutrophils in chronic inflammation.
messages: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
messages: Secreted

9544:SMARCA5
gene id: 9544:SMARCA5
uniprot id: A0A8J8XXF4
uniprot id: H9EMS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9544:SAMHD1
gene id: 9544:SAMHD1
uniprot id: A0A8J8YMA9
uniprot id: G7N4W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

9544:LOC713408
gene id: 9544:LOC713408
uniprot id: F6VNG0
names: Similarity
messages: Belongs to the LCE family.

9544:MSRA
gene id: 9544:MSRA
uniprot id: H9EVZ9
uniprot id: H9FUP1
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

9544:ATF7IP2
gene id: 9544:ATF7IP2
uniprot id: F6WW46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9544:ELMO1
gene id: 9544:ELMO1
uniprot id: A0A8J8Y783
uniprot id: F7DM33
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9544:CTSA
gene id: 9544:CTSA
uniprot id: F7G1E1
uniprot id: G7N4N3
names: Similarity
messages: Belongs to the peptidase S10 family.

9544:GDI2
gene id: 9544:GDI2
uniprot id: H9ELY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9544:CORO2B
gene id: 9544:CORO2B
uniprot id: F7HBV6
names: Similarity
messages: Belongs to the WD repeat coronin family.

9544:PAX9
gene id: 9544:PAX9
uniprot id: A0A5S7WYN3
names: Subcellular Location Annotation
messages: Nucleus

9544:THOC6
gene id: 9544:THOC6
uniprot id: A0A8J8YET4
uniprot id: F7DB82
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9544:HSP90AA1
gene id: 9544:HSP90AA1
uniprot id: A0A5F8ARZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9544:EWSR1
gene id: 9544:EWSR1
uniprot id: F7FHZ8
uniprot id: H9ENA5
uniprot id: H9ENA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9544:CD74
gene id: 9544:CD74
uniprot id: F7E9S4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CXCL8
gene id: 9544:CXCL8
uniprot id: P67813
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
messages: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
messages: Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.
messages: Secreted

9544:LOC705226
gene id: 9544:LOC705226
uniprot id: F6RAP3
uniprot id: G7MT42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9544:TMEM9
gene id: 9544:TMEM9
uniprot id: A0A8J8YIL4
uniprot id: F6ZEB5
uniprot id: F6ZER3
names: Similarity
messages: Belongs to the TMEM9 family.

9544:SLC14A1
gene id: 9544:SLC14A1
uniprot id: A0A1D5QMW3
uniprot id: F7GPB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9544:CKMT2
gene id: 9544:CKMT2
uniprot id: G7MV65
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9544:SLC35C2
gene id: 9544:SLC35C2
uniprot id: A0A8J8Y7B8
uniprot id: G7N4M3
uniprot id: H9YZE6
names: Subcellular Location Annotation
messages: Membrane

9544:SCN5A
gene id: 9544:SCN5A
uniprot id: F7CEN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9544:LOC694887
gene id: 9544:LOC694887
uniprot id: F7B4W4
names: Similarity
messages: Belongs to the pro/parathymosin family.

9544:EPHA7
gene id: 9544:EPHA7
uniprot id: A0A8J8XG70
uniprot id: G7MPY1
names: Subcellular Location Annotation
messages: Membrane

9544:IRX1
gene id: 9544:IRX1
uniprot id: A0A5F7ZE04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9544:HIST1H2AJ
gene id: 9544:HIST1H2AJ
uniprot id: A0A8J8Y2B6
uniprot id: F7C6Q8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:GGCX
gene id: 9544:GGCX
uniprot id: F7GN41
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:SAP30
gene id: 9544:SAP30
uniprot id: F6PPX3
names: Similarity
messages: Belongs to the SAP30 family.

9544:HADHA
gene id: 9544:HADHA
uniprot id: I0FL67
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9544:TP53
gene id: 9544:TP53
uniprot id: A0A8J8XH32
uniprot id: E3U906
uniprot id: P56424
names: Cofactor
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Acetylation of Lys-382 by EP300. Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-381 increases stability. Deacetylation at Lys-381 by SIRT6 decreases its stability, thereby regulating cell senescence.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interactio…
messages: Mitochondrion matrix
messages: Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).
messages: Nucleus
messages: PML body
messages: Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter (By similarity). Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Thr-55 by TAF1 which promotes MDM2-mediated TP53 degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).
messages: Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9 (By similarity).
messages: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
messages: Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (By similarity).
messages: centrosome
messages: p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.

9544:LRP10
gene id: 9544:LRP10
uniprot id: A0A8J8Y1D2
uniprot id: G7MX26
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:GMPR
gene id: 9544:GMPR
uniprot id: A0A8J8XFV5
uniprot id: G7MQS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9544:LYRM7
gene id: 9544:LYRM7
uniprot id: H9G1K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9544:TMED7
gene id: 9544:TMED7
uniprot id: H9ESZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9544:LOC713991
gene id: 9544:LOC713991
uniprot id: F7FX28
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9544:MARCH4
gene id: 9544:MARCH4
uniprot id: A0A8J8YPJ0
uniprot id: F7HSL8
names: Subcellular Location Annotation
messages: Membrane

9544:IDH3B
gene id: 9544:IDH3B
uniprot id: A0A1D5QKS1
uniprot id: A0A8J8XUN1
uniprot id: H9EUD0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9544:NDUFV2
gene id: 9544:NDUFV2
uniprot id: F7HLZ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9544:NINJ2
gene id: 9544:NINJ2
uniprot id: A0A1D5R217
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9544:CDK9
gene id: 9544:CDK9
uniprot id: H9FNK6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:MRPL23
gene id: 9544:MRPL23
uniprot id: I0FU14
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9544:GABRE
gene id: 9544:GABRE
uniprot id: A0A8J8YFY5
uniprot id: F7GJ80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:CAPZA2
gene id: 9544:CAPZA2
uniprot id: F7H1J4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9544:TRIM11
gene id: 9544:TRIM11
uniprot id: F7GJX2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:CDC123
gene id: 9544:CDC123
uniprot id: A0A8J8XAY5
uniprot id: F7HCL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9544:CHGA
gene id: 9544:CHGA
uniprot id: H9FPA7
uniprot id: Q6DTM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9544:NIPSNAP2
gene id: 9544:NIPSNAP2
uniprot id: I2CWV1
names: Similarity
messages: Belongs to the NipSnap family.

9544:GPR137B
gene id: 9544:GPR137B
uniprot id: A0A5K1VRW0
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9544:SLC28A1
gene id: 9544:SLC28A1
uniprot id: A0A5K1V241
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9544:SLC30A8
gene id: 9544:SLC30A8
uniprot id: A0A5F8AAT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9544:ATP5F1A
gene id: 9544:ATP5F1A
uniprot id: A0A8J8YE30
uniprot id: I2CUC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9544:PIK3R3
gene id: 9544:PIK3R3
uniprot id: F6WVD4
uniprot id: H9G113
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9544:BABAM1
gene id: 9544:BABAM1
uniprot id: F6SMG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9544:BANP
gene id: 9544:BANP
uniprot id: A0A5F8AJT1
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9544:PTN
gene id: 9544:PTN
uniprot id: A0A5F7ZTC0
uniprot id: A0A8J8Y1N0
uniprot id: G7MML7
names: Similarity
messages: Belongs to the pleiotrophin family.

9544:DNAJC27
gene id: 9544:DNAJC27
uniprot id: A0A8J8YPP3
uniprot id: F7AC47
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9544:USP24
gene id: 9544:USP24
uniprot id: A0A5F8A5B3
names: Similarity
messages: Belongs to the peptidase C19 family.

9544:KCNH3
gene id: 9544:KCNH3
uniprot id: G7N6W9
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9544:IDO2
gene id: 9544:IDO2
uniprot id: A0A1D5QYX0
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9544:PADI6
gene id: 9544:PADI6
uniprot id: A0A8J8XMQ5
uniprot id: F6X3G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9544:ARL5A
gene id: 9544:ARL5A
uniprot id: H9YX71
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9544:FGFR1OP2
gene id: 9544:FGFR1OP2
uniprot id: H9EN32
uniprot id: I0FM31
names: Similarity
messages: Belongs to the SIKE family.

9544:NXPH4
gene id: 9544:NXPH4
uniprot id: F7DEE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9544:HR
gene id: 9544:HR
uniprot id: Q8WNL9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9544:CHRM3
gene id: 9544:CHRM3
uniprot id: A0A8J8XRC4
uniprot id: F7EAQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9544:PFDN5
gene id: 9544:PFDN5
uniprot id: F7HTC8
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9544:LOC574310
gene id: 9544:LOC574310
uniprot id: Q5I2Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9544:INSIG2
gene id: 9544:INSIG2
uniprot id: F7HBW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9544:NME1
gene id: 9544:NME1
uniprot id: F6TRJ3
names: Similarity
messages: Belongs to the NDK family.

9544:BBS2
gene id: 9544:BBS2
uniprot id: G7NPC3
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9544:C6H5orf63
gene id: 9544:C6H5orf63
uniprot id: H9EWU2
names: Similarity
messages: Belongs to the glutaredoxin family.

9544:VTA1
gene id: 9544:VTA1
uniprot id: F6TI07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9544:OPN1SW
gene id: 9544:OPN1SW
uniprot id: A0A8J8XV38
uniprot id: F6ZZ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: perinuclear region
messages: photoreceptor outer segment

9544:LOC106992372
gene id: 9544:LOC106992372
uniprot id: A0A5F8AUD7
names: Subcellular Location Annotation
messages: Membrane

9544:ING5
gene id: 9544:ING5
uniprot id: H9G0P4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9544:CCDC149
gene id: 9544:CCDC149
uniprot id: F6SES1
uniprot id: I2CTJ2
names: Similarity
messages: Belongs to the CCDC149 family.

9544:GNRHR
gene id: 9544:GNRHR
uniprot id: F7GVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:LOC702608
gene id: 9544:LOC702608
uniprot id: A0A5F7ZXM9
names: Similarity
messages: Belongs to the TMEM14 family.

9544:LTB4R
gene id: 9544:LTB4R
uniprot id: G7MXC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9544:ATG4C
gene id: 9544:ATG4C
uniprot id: H9EUS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9544:KEG06 p01
gene id: 9544:KEG06_p01
uniprot id: A0A088CFM7
uniprot id: Q6IYG6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9544:CREM
gene id: 9544:CREM
uniprot id: F6YPU2
names: Subcellular Location Annotation
messages: Nucleus

9544:TAF9
gene id: 9544:TAF9
uniprot id: F7E5B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9544:DOK4
gene id: 9544:DOK4
uniprot id: A0A8J8XDI8
uniprot id: F6VK00
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9544:PLA2G2E
gene id: 9544:PLA2G2E
uniprot id: A0A5F8AEH8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9544:LYRM4
gene id: 9544:LYRM4
uniprot id: H9FMX8
names: Similarity
messages: Belongs to the complex I LYR family.

9544:EPHB6
gene id: 9544:EPHB6
uniprot id: F7GJU4
names: Subcellular Location Annotation
messages: Membrane

9544:PGD
gene id: 9544:PGD
uniprot id: F7GIV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9544:BCLAF1
gene id: 9544:BCLAF1
uniprot id: H9G2F8
uniprot id: H9G2F9
uniprot id: H9G2G0
uniprot id: H9ZFV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCLAF1/THRAP3 family.
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Nucleus

9544:EOGT
gene id: 9544:EOGT
uniprot id: A0A8J8YA85
uniprot id: F7FX04
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9544:LOC693506
gene id: 9544:LOC693506
uniprot id: H9H3F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9544:POLL
gene id: 9544:POLL
uniprot id: A0A8J8YHH3
uniprot id: F7HD68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9544:NUBPL
gene id: 9544:NUBPL
uniprot id: A0A1D5R8A7
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9544:CS
gene id: 9544:CS
uniprot id: F7HGU4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

9544:ZMPSTE24
gene id: 9544:ZMPSTE24
uniprot id: A0A1D5Q518
uniprot id: A0A8J8XES9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9544:DYNC1LI1
gene id: 9544:DYNC1LI1
uniprot id: H9FVA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9544:PSMA5
gene id: 9544:PSMA5
uniprot id: A0A8J8Y2U9
uniprot id: I0FTI7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9544:TAFA3
gene id: 9544:TAFA3
uniprot id: G7MII5
names: Similarity
messages: Belongs to the TAFA family.

9544:OR10G2
gene id: 9544:OR10G2
uniprot id: F7H0B8
names: Subcellular Location Annotation
messages: Membrane

9544:TRIP10
gene id: 9544:TRIP10
uniprot id: F7E230
uniprot id: F7E5U8
names: Subcellular Location Annotation
messages: cytoskeleton

9544:TMPRSS11D
gene id: 9544:TMPRSS11D
uniprot id: A0A5F8ANS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9544:PSAT1
gene id: 9544:PSAT1
uniprot id: F7H2J6
uniprot id: F7H2J8
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

9544:LYRM2
gene id: 9544:LYRM2
uniprot id: A0A1D5Q1D8
names: Similarity
messages: Belongs to the complex I LYR family.

9544:CPNE4
gene id: 9544:CPNE4
uniprot id: A0A8J8YFA1
uniprot id: G7MJS2
names: Similarity
messages: Belongs to the copine family.

9544:NIPBL
gene id: 9544:NIPBL
uniprot id: F6XIX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9544:TTC21A
gene id: 9544:TTC21A
uniprot id: F6TYS9
names: Similarity
messages: Belongs to the TTC21 family.

9544:CMPK1
gene id: 9544:CMPK1
uniprot id: I0FMC3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9544:LOC711318
gene id: 9544:LOC711318
uniprot id: F6SGN0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9544:UGT8
gene id: 9544:UGT8
uniprot id: A0A5F8A3A1
uniprot id: F7BAK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9544:ORAI2
gene id: 9544:ORAI2
uniprot id: A0A1D5R3E4
uniprot id: A0A8J8XPU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9544:PDE3A
gene id: 9544:PDE3A
uniprot id: F7HBP7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:NUDT3
gene id: 9544:NUDT3
uniprot id: I0FNV7
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9544:DMTN
gene id: 9544:DMTN
uniprot id: H9FR35
uniprot id: I0FPW8
uniprot id: I0FPW9
names: Subcellular Location Annotation
messages: Cytoplasm

9544:NKX6-1
gene id: 9544:NKX6-1
uniprot id: F7H8N6
names: Subcellular Location Annotation
messages: Nucleus

9544:SYNPR
gene id: 9544:SYNPR
uniprot id: F7HAV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9544:WNT2B
gene id: 9544:WNT2B
uniprot id: A0A8J8Y7F1
uniprot id: G7MII1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:TRIM32
gene id: 9544:TRIM32
uniprot id: F6ZUB8
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9544:WIF1
gene id: 9544:WIF1
uniprot id: A0A8J8Y2M9
uniprot id: H9FPD0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:SLC2A5
gene id: 9544:SLC2A5
uniprot id: A0A1D5QWB5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Membrane
messages: sarcolemma

9544:AIF1L
gene id: 9544:AIF1L
uniprot id: A0A5F8A5G1
names: Subcellular Location Annotation
messages: ruffle membrane

9544:HYOU1
gene id: 9544:HYOU1
uniprot id: H9Z4E0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9544:GALNT18
gene id: 9544:GALNT18
uniprot id: A0A8J8YHR2
uniprot id: G7NDX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:CLCA1
gene id: 9544:CLCA1
uniprot id: Q6PT52
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLCR family.
messages: Glycosylated.
messages: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC (By similarity).
messages: The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.
messages: The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
messages: extracellular space

9544:SV2C
gene id: 9544:SV2C
uniprot id: A0A8J8YE61
uniprot id: F7GQK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9544:TRAF1
gene id: 9544:TRAF1
uniprot id: A0A8J8XAG6
uniprot id: F7GHV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9544:GJD3
gene id: 9544:GJD3
uniprot id: F7FAS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:ATP8B2
gene id: 9544:ATP8B2
uniprot id: A0A5F7ZAI4
uniprot id: F7E886
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9544:KPNA1
gene id: 9544:KPNA1
uniprot id: A0A8J8YPE6
uniprot id: F7G2W5
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9544:ZDHHC12
gene id: 9544:ZDHHC12
uniprot id: I0FVS9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:EZH2
gene id: 9544:EZH2
uniprot id: F6ZEX1
uniprot id: G7MN86
uniprot id: H9Z6A1
uniprot id: H9Z6A2
names: Subcellular Location Annotation
messages: Nucleus

9544:DRAM1
gene id: 9544:DRAM1
uniprot id: A0A8J8XW07
uniprot id: F6RM51
names: Subcellular Location Annotation
messages: Membrane

9544:MRPL46
gene id: 9544:MRPL46
uniprot id: G7MYR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

9544:LOC693513
gene id: 9544:LOC693513
uniprot id: F7HKJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:CASQ2
gene id: 9544:CASQ2
uniprot id: A0A5K1UGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9544:SLC10A1
gene id: 9544:SLC10A1
uniprot id: A0A8J8XR54
uniprot id: F6YRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9544:ISL1
gene id: 9544:ISL1
uniprot id: A0A8J8XGP4
uniprot id: F6XYB8
names: Subcellular Location Annotation
messages: Nucleus

9544:TMEM177
gene id: 9544:TMEM177
uniprot id: A0A5F8AFC3
uniprot id: G8F1U2
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

9544:RRP12
gene id: 9544:RRP12
uniprot id: F7AUU2
names: Similarity
messages: Belongs to the RRP12 family.

9544:CDK2
gene id: 9544:CDK2
uniprot id: A0A8J8XG04
uniprot id: G7N7A7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:ABCA3
gene id: 9544:ABCA3
uniprot id: A0A5K1U3Q1
names: Subcellular Location Annotation
messages: Membrane

9544:C4BPB
gene id: 9544:C4BPB
uniprot id: F6XIH5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ING3
gene id: 9544:ING3
uniprot id: A0A8J8XD65
uniprot id: G7MM72
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9544:AFF1
gene id: 9544:AFF1
uniprot id: A0A1D5QFC5
uniprot id: F7CE41
names: Similarity
messages: Belongs to the AF4 family.

9544:FLNB
gene id: 9544:FLNB
uniprot id: F6YS66
names: Similarity
messages: Belongs to the filamin family.

9544:PFN4
gene id: 9544:PFN4
uniprot id: A0A8J8Y8Z1
uniprot id: F6XA76
names: Similarity
messages: Belongs to the profilin family.

9544:RASSF1
gene id: 9544:RASSF1
uniprot id: H9Z4T9
names: Subcellular Location Annotation
messages: cytoskeleton

9544:EIF3M
gene id: 9544:EIF3M
uniprot id: H9EQL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9544:RNF114
gene id: 9544:RNF114
uniprot id: F6RK58
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
messages: Nucleus

9544:LCA5
gene id: 9544:LCA5
uniprot id: A0A8J8XRT6
uniprot id: G7MPS6
names: Similarity
messages: Belongs to the LCA5 family.

9544:LOC722074
gene id: 9544:LOC722074
uniprot id: F6SYX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

9544:BDH1
gene id: 9544:BDH1
uniprot id: A0A8J8XCY6
uniprot id: G7MKG3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:FZD4
gene id: 9544:FZD4
uniprot id: A0A1D5Q1B1
uniprot id: A0A5F8AC06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9544:ADAMTS4
gene id: 9544:ADAMTS4
uniprot id: A0A8J8XAH9
uniprot id: G7ME94
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:FUT1
gene id: 9544:FUT1
uniprot id: A0A8J8Y607
uniprot id: Q9TUD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

9544:FOXD2
gene id: 9544:FOXD2
uniprot id: F6YN08
names: Subcellular Location Annotation
messages: Nucleus

9544:TMED10
gene id: 9544:TMED10
uniprot id: A0A1D5R1P2
uniprot id: A0A8J8XRL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CARTPT
gene id: 9544:CARTPT
uniprot id: A0A8J8XAQ1
uniprot id: F6WIA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9544:BRIX1
gene id: 9544:BRIX1
uniprot id: A0A1D5RA59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9544:TIMM10B
gene id: 9544:TIMM10B
uniprot id: A0A8J8Y3K4
uniprot id: F7C8X4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9544:PAX5
gene id: 9544:PAX5
uniprot id: A0A8J8XLV0
uniprot id: G7NF13
names: Subcellular Location Annotation
messages: Nucleus

9544:COPA
gene id: 9544:COPA
uniprot id: A0A8J8XWI1
uniprot id: G7ME70
uniprot id: H9FPZ1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9544:ACOT8
gene id: 9544:ACOT8
uniprot id: A0A5F7Z994
uniprot id: F7G1G6
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9544:COA5
gene id: 9544:COA5
uniprot id: I0FMJ9
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9544:SLCO2B1
gene id: 9544:SLCO2B1
uniprot id: H9Z4X7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:KCTD15
gene id: 9544:KCTD15
uniprot id: A0A5K1VP15
names: Subcellular Location Annotation
messages: Cell membrane

9544:SLC35E1
gene id: 9544:SLC35E1
uniprot id: F7GVS0
names: Subcellular Location Annotation
messages: Membrane

9544:CX3CL1
gene id: 9544:CX3CL1
uniprot id: Q8HXZ1
names: Subcellular Location Annotation
messages: Secreted

9544:YIF1A
gene id: 9544:YIF1A
uniprot id: F7CUN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

9544:SPPL3
gene id: 9544:SPPL3
uniprot id: H9EPH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9544:IFITM5
gene id: 9544:IFITM5
uniprot id: F6PZ75
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:ELF5
gene id: 9544:ELF5
uniprot id: A0A8J8YNF4
uniprot id: F6PLC7
uniprot id: F6PLD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:WNT9B
gene id: 9544:WNT9B
uniprot id: A0A5F7ZY04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:SEZ6
gene id: 9544:SEZ6
uniprot id: F7F6J3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:AKIRIN2
gene id: 9544:AKIRIN2
uniprot id: H9EMR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9544:LOC698693
gene id: 9544:LOC698693
uniprot id: G7N3T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9544:NTS
gene id: 9544:NTS
uniprot id: A0A8J8XPI2
uniprot id: F7FDR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9544:MAPK13
gene id: 9544:MAPK13
uniprot id: H9ZBA4
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

9544:DSTN
gene id: 9544:DSTN
uniprot id: H9EM17
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9544:HNRNPA1
gene id: 9544:HNRNPA1
uniprot id: Q28521
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SEPT6, C9orf72, KHDRBS1, UBQLN2 (By similarity). Interacts with PPIA/CYPA (By similarity).
messages: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins.
messages: Nucleus
messages: Sumoylated.

9544:POMGNT1
gene id: 9544:POMGNT1
uniprot id: A0A1D5QKD7
uniprot id: F7GR52
uniprot id: G7MGQ7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9544:RUVBL1
gene id: 9544:RUVBL1
uniprot id: A0A8J8XMP3
uniprot id: F6VIT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9544:ELAC1
gene id: 9544:ELAC1
uniprot id: A0A8J8Y9Z5
uniprot id: G7NKQ7
names: Subunit
messages: Homodimer.

9544:GPCPD1
gene id: 9544:GPCPD1
uniprot id: A0A8J8XB88
uniprot id: G7N2X2
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9544:DYNLT1
gene id: 9544:DYNLT1
uniprot id: A0A8J8XVU0
uniprot id: F6QZS9
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9544:LOC710110
gene id: 9544:LOC710110
uniprot id: A0A1D5R1V1
uniprot id: F6Y0X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9544:PCYOX1
gene id: 9544:PCYOX1
uniprot id: F7HQU2
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9544:PLD3
gene id: 9544:PLD3
uniprot id: A0A8J8XPJ4
uniprot id: F6W2K4
names: Similarity
messages: Belongs to the phospholipase D family.

9544:SLIT2
gene id: 9544:SLIT2
uniprot id: F7H9D1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:PCYT1B
gene id: 9544:PCYT1B
uniprot id: A0A1D5RCC8
uniprot id: A0A8J8YE25
uniprot id: F6TCK2
uniprot id: H9EQB3
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9544:BIRC2
gene id: 9544:BIRC2
uniprot id: A0A8J8XPA8
uniprot id: H9EQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9544:BLOC1S3
gene id: 9544:BLOC1S3
uniprot id: F6U731
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S3 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).
messages: Cytoplasm

9544:DYNC1I2
gene id: 9544:DYNC1I2
uniprot id: F7F396
uniprot id: F7GNP7
uniprot id: H9FQT8
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9544:MYH3
gene id: 9544:MYH3
uniprot id: F7GP56
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:MAN1B1
gene id: 9544:MAN1B1
uniprot id: F7GR74
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9544:ATAD2B
gene id: 9544:ATAD2B
uniprot id: A0A5K1VRM9
uniprot id: A0A8J8XZ62
uniprot id: G7N9I1
names: Similarity
messages: Belongs to the AAA ATPase family.

9544:PANX3
gene id: 9544:PANX3
uniprot id: A0A8J8YEY7
uniprot id: F6THN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9544:KEG06 p07
gene id: 9544:KEG06_p07
uniprot id: Q6IYH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

9544:SLC41A2
gene id: 9544:SLC41A2
uniprot id: A0A8J8XKV4
uniprot id: F7H2Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9544:GTF2A2
gene id: 9544:GTF2A2
uniprot id: A0A1D5QF26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9544:CCL11
gene id: 9544:CCL11
uniprot id: Q8HXZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:THYN1
gene id: 9544:THYN1
uniprot id: A0A5F7ZVQ2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9544:KPNA4
gene id: 9544:KPNA4
uniprot id: F7EGK1
uniprot id: H9EQP0
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9544:PRDM1
gene id: 9544:PRDM1
uniprot id: A0A1D5QYV9
uniprot id: G7MQ03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9544:ABCA5
gene id: 9544:ABCA5
uniprot id: A0A5K1TX02
names: Subcellular Location Annotation
messages: Membrane

9544:TRAF4
gene id: 9544:TRAF4
uniprot id: H9ET39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9544:GPKOW
gene id: 9544:GPKOW
uniprot id: F7D1Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus
messages: RNA-binding protein involved in pre-mRNA splicing.

9544:LOC710487
gene id: 9544:LOC710487
uniprot id: A0A7R8C3D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:CWF19L1
gene id: 9544:CWF19L1
uniprot id: A0A5F8AH68
uniprot id: F6X973
uniprot id: H9FWP3
names: Similarity
messages: Belongs to the CWF19 family.

9544:SUPT16H
gene id: 9544:SUPT16H
uniprot id: A0A8J8Y0U1
uniprot id: G7MWS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9544:ZNF18
gene id: 9544:ZNF18
uniprot id: A0A8J8Y8T8
uniprot id: G7NIT3
names: Subcellular Location Annotation
messages: Nucleus

9544:C8H8orf82
gene id: 9544:C8H8orf82
uniprot id: F6XB79
names: Similarity
messages: Belongs to the UPF0598 family.

9544:NEFL
gene id: 9544:NEFL
uniprot id: F7ED68
uniprot id: G8F1E8
names: Similarity
messages: Belongs to the intermediate filament family.

9544:DRC7
gene id: 9544:DRC7
uniprot id: A0A8J8YRY8
uniprot id: F6STW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

9544:GPRC6A
gene id: 9544:GPRC6A
uniprot id: F6U248
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:C14H11orf54
gene id: 9544:C14H11orf54
uniprot id: F6PT50
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9544:CHD6
gene id: 9544:CHD6
uniprot id: F6VZQ8
uniprot id: F6VZS6
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9544:REEP6
gene id: 9544:REEP6
uniprot id: I0FWF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9544:ATP6V1E2
gene id: 9544:ATP6V1E2
uniprot id: A0A8J8Y8R9
uniprot id: F7GUI3
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9544:VPS33A
gene id: 9544:VPS33A
uniprot id: F7HG54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9544:HAPLN4
gene id: 9544:HAPLN4
uniprot id: A0A1D5QQ66
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:INSL3
gene id: 9544:INSL3
uniprot id: D7RNQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

9544:CXCL1
gene id: 9544:CXCL1
uniprot id: Q8HXZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9544:APOM
gene id: 9544:APOM
uniprot id: F7CSV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9544:TARDBP
gene id: 9544:TARDBP
uniprot id: H9EMX3
names: Subcellular Location Annotation
messages: Nucleus

9544:SSR3
gene id: 9544:SSR3
uniprot id: H9YW96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9544:MYO5A
gene id: 9544:MYO5A
uniprot id: A0A1D5Q1J3
uniprot id: F6QDX8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:RBM22
gene id: 9544:RBM22
uniprot id: F6PL59
names: Similarity
messages: Belongs to the SLT11 family.

9544:TSPAN31
gene id: 9544:TSPAN31
uniprot id: A0A8J8YT40
uniprot id: F7HCX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:KCTD16
gene id: 9544:KCTD16
uniprot id: A0A8J8YMY0
uniprot id: G7MVD5
names: Subcellular Location Annotation
messages: Cell membrane

9544:IK
gene id: 9544:IK
uniprot id: H9EPN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9544:EXOSC3
gene id: 9544:EXOSC3
uniprot id: A0A1D5Q1B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm
messages: nucleolus

9544:OR2H2
gene id: 9544:OR2H2
uniprot id: I2CT49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:YAF2
gene id: 9544:YAF2
uniprot id: F7G033
uniprot id: F7HRL7
names: Subcellular Location Annotation
messages: Nucleus

9544:MMGT1
gene id: 9544:MMGT1
uniprot id: A0A8J8XMV0
uniprot id: F7HN17
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

9544:NAALAD2
gene id: 9544:NAALAD2
uniprot id: G7NBF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9544:CSTF2
gene id: 9544:CSTF2
uniprot id: A0A1D5QUW9
uniprot id: A0A8J8YSW5
uniprot id: F7HR34
uniprot id: G7NSF8
names: Subcellular Location Annotation
messages: Nucleus

9544:TRAPPC3L
gene id: 9544:TRAPPC3L
uniprot id: F6SXJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9544:RPL5
gene id: 9544:RPL5
uniprot id: F7C4N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9544:EDC4
gene id: 9544:EDC4
uniprot id: A0A5F7ZFU7
uniprot id: F7HN31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9544:PIP4P1
gene id: 9544:PIP4P1
uniprot id: F6T137
uniprot id: H9G1L2
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9544:FAS
gene id: 9544:FAS
uniprot id: Q9BDP2
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds DAXX. Interacts with HIPK3 (By similarity). Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BABAM2 and FEM1B. Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity). Interacts with CALM (By similarity). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X is further enhanced upon receptor stimulation and accompanied by DDX3X and BIRC2 cleavage (By similarity).
messages: Cell membrane
messages: Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
messages: Membrane raft
messages: Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane.
messages: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).

9544:NEK6
gene id: 9544:NEK6
uniprot id: F7H6C1
uniprot id: F7H6C5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:ADGRG7
gene id: 9544:ADGRG7
uniprot id: A0A1D5QMM0
names: Subcellular Location Annotation
messages: Membrane

9544:ZNF197
gene id: 9544:ZNF197
uniprot id: G7MIW1
uniprot id: H9ES79
names: Subcellular Location Annotation
messages: Nucleus

9544:CADM4
gene id: 9544:CADM4
uniprot id: I2CY70
names: Similarity
messages: Belongs to the nectin family.

9544:GRIA3
gene id: 9544:GRIA3
uniprot id: A0A5F7ZAW6
uniprot id: F7F735
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:CCR1
gene id: 9544:CCR1
uniprot id: A0A8J8YDN5
uniprot id: F6QJR2
uniprot id: P56482
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with CREB3.
messages: Membrane
messages: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

9544:UBA5
gene id: 9544:UBA5
uniprot id: H9EVI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9544:ARMC8
gene id: 9544:ARMC8
uniprot id: A0A1D5Q324
uniprot id: A0A1D5QZ15
uniprot id: A0A5F7ZJD1
uniprot id: H9EN37
uniprot id: H9EN38
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:GGH
gene id: 9544:GGH
uniprot id: F7E4X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9544:RPAP2
gene id: 9544:RPAP2
uniprot id: A0A1D5RGI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

9544:POU6F1
gene id: 9544:POU6F1
uniprot id: A0A1D5QL75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9544:ZFP36L1
gene id: 9544:ZFP36L1
uniprot id: A0A8J8YSY5
uniprot id: G7MYI0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9544:FAM114A1
gene id: 9544:FAM114A1
uniprot id: A0A5K1UGQ3
names: Similarity
messages: Belongs to the FAM114 family.

9544:SCARA5
gene id: 9544:SCARA5
uniprot id: F7HRA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9544:NRXN3
gene id: 9544:NRXN3
uniprot id: H9G1Z6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Presynaptic cell membrane

9544:UBIAD1
gene id: 9544:UBIAD1
uniprot id: A0A8J8Y0Q2
uniprot id: F7GJ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9544:TSG101
gene id: 9544:TSG101
uniprot id: A0A8J8XCK1
uniprot id: G7NDS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Membrane

9544:ANXA2
gene id: 9544:ANXA2
uniprot id: A0A8J8XSX8
uniprot id: F7H0C6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

9544:HOMER1
gene id: 9544:HOMER1
uniprot id: H9EPI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9544:TIGD5
gene id: 9544:TIGD5
uniprot id: F7FLV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tigger transposable element derived protein family.
messages: Nucleus

9544:SLC6A2
gene id: 9544:SLC6A2
uniprot id: Q9MYW7
uniprot id: Q9MYW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9544:HS6ST1
gene id: 9544:HS6ST1
uniprot id: H9ZFH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

9544:FAM126B
gene id: 9544:FAM126B
uniprot id: A0A5F7ZDS5
uniprot id: A0A5F8AFC2
uniprot id: A0A8J8XXT9
uniprot id: F6VFY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9544:SCNM1
gene id: 9544:SCNM1
uniprot id: A0A8J8YB23
uniprot id: F6PSF1
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: nucleoplasm

9544:PRRT2
gene id: 9544:PRRT2
uniprot id: F6YBL7
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:LANCL1
gene id: 9544:LANCL1
uniprot id: A0A8J8YEH5
uniprot id: F7B2A9
names: Similarity
messages: Belongs to the LanC-like protein family.

9544:NPNT
gene id: 9544:NPNT
uniprot id: F7F563
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:RMI1
gene id: 9544:RMI1
uniprot id: F6VJJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9544:ART1
gene id: 9544:ART1
uniprot id: A0A8J8XXU8
uniprot id: F6ZMC4
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9544:CCNL1
gene id: 9544:CCNL1
uniprot id: H9EPW8
names: Similarity
messages: Belongs to the cyclin family.

9544:TAS2R38
gene id: 9544:TAS2R38
uniprot id: F1T2U1
uniprot id: F1T2U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

9544:BMP10
gene id: 9544:BMP10
uniprot id: A0A8J8YQK3
uniprot id: F6TKR2
names: Similarity
messages: Belongs to the TGF-beta family.

9544:SPIN4
gene id: 9544:SPIN4
uniprot id: A0A8J8XCB2
uniprot id: F7EXC3
names: Similarity
messages: Belongs to the SPIN/STSY family.

9544:VPS41
gene id: 9544:VPS41
uniprot id: A0A8J8XQV6
uniprot id: G7MLG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9544:CLPTM1L
gene id: 9544:CLPTM1L
uniprot id: A0A5F7ZAX1
uniprot id: F7CT38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9544:MTMR11
gene id: 9544:MTMR11
uniprot id: F7BEA2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9544:GJA4
gene id: 9544:GJA4
uniprot id: A0A654IC41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:FICD
gene id: 9544:FICD
uniprot id: A0A8J8XFD5
uniprot id: F7H343
names: Similarity
messages: Belongs to the fic family.

9544:EBAG9
gene id: 9544:EBAG9
uniprot id: H9Z393
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9544:TMLHE
gene id: 9544:TMLHE
uniprot id: A0A8J8YF36
uniprot id: G7NSZ0
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

9544:ARRDC1
gene id: 9544:ARRDC1
uniprot id: H9ZFD9
names: Similarity
messages: Belongs to the arrestin family.

9544:TIMP3
gene id: 9544:TIMP3
uniprot id: G1K371
uniprot id: Q5PXZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (By similarity).
messages: Interacts with EFEMP1.
messages: extracellular matrix

9544:LOC106996511
gene id: 9544:LOC106996511
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:ELAVL2
gene id: 9544:ELAVL2
uniprot id: F6TG57
uniprot id: H9ENU4
uniprot id: I0FPT1
names: Similarity
messages: Belongs to the RRM elav family.

9544:SLC52A1
gene id: 9544:SLC52A1
uniprot id: F6U0Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9544:CALHM5
gene id: 9544:CALHM5
uniprot id: G7MQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9544:ESR1
gene id: 9544:ESR1
uniprot id: A0A8J8Y5E1
uniprot id: F6QUR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

9544:DSC1
gene id: 9544:DSC1
uniprot id: A0A8J8XY34
uniprot id: F7HEJ3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9544:FGF18
gene id: 9544:FGF18
uniprot id: F6SVA9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:ALLC
gene id: 9544:ALLC
uniprot id: G8F1H6
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9544:GOLT1A
gene id: 9544:GOLT1A
uniprot id: A0A8J8YIJ8
uniprot id: F7H558
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9544:PTPN4
gene id: 9544:PTPN4
uniprot id: F6WK37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9544:SFMBT1
gene id: 9544:SFMBT1
uniprot id: A0A5F8A9B8
names: Subcellular Location Annotation
messages: Nucleus

9544:PDK2
gene id: 9544:PDK2
uniprot id: A0A8J8XV72
uniprot id: G7NHF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9544:SFRP2
gene id: 9544:SFRP2
uniprot id: A0A8J8Y2W6
uniprot id: G7MS58
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:EVA1A
gene id: 9544:EVA1A
uniprot id: A0A8J8YR48
uniprot id: F6Y876
names: Similarity
messages: Belongs to the EVA1 family.

9544:RPS4X
gene id: 9544:RPS4X
uniprot id: F7FG14
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9544:NR2C2
gene id: 9544:NR2C2
uniprot id: A0A1D5RHB0
uniprot id: A0A8J8XKY0
uniprot id: F7D8H6
uniprot id: G7N7T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:LOC707129
gene id: 9544:LOC707129
uniprot id: F7A635
names: Similarity
messages: Belongs to the intermediate filament family.

9544:MAK16
gene id: 9544:MAK16
uniprot id: A0A8J8YL15
uniprot id: G7MZ28
names: Similarity
messages: Belongs to the MAK16 family.

9544:SLC1A3
gene id: 9544:SLC1A3
uniprot id: A0A8J8YC68
uniprot id: I2CTJ9
uniprot id: I2CYT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9544:PDE7A
gene id: 9544:PDE7A
uniprot id: A0A8J8YCM1
uniprot id: F6WPU0
uniprot id: G7MZG5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:PLPP5
gene id: 9544:PLPP5
uniprot id: F7FW46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:CLDN10
gene id: 9544:CLDN10
uniprot id: A0A8J8Y9F3
uniprot id: F6ZXB6
uniprot id: F6ZXC4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:DCTPP1
gene id: 9544:DCTPP1
uniprot id: A0A1D5QTQ8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9544:USE1
gene id: 9544:USE1
uniprot id: F6PM29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:PIPOX
gene id: 9544:PIPOX
uniprot id: A0A8J8XTA3
uniprot id: F6XXQ3
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9544:KPNA5
gene id: 9544:KPNA5
uniprot id: A0A1D5QVJ1
uniprot id: H9EPP2
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9544:LOC708874
gene id: 9544:LOC708874
uniprot id: A0A5F7ZAH7
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:ANAPC13
gene id: 9544:ANAPC13
uniprot id: A0A8J8YFD1
uniprot id: F7ENP2
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9544:KXD1
gene id: 9544:KXD1
uniprot id: F7GN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9544:COX5A
gene id: 9544:COX5A
uniprot id: A0A8J8Y8P5
uniprot id: G7MYC6
uniprot id: Q53CF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with AFG1L (By similarity). Interacts with RAB5IF (By similarity).
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9544:CCNG2
gene id: 9544:CCNG2
uniprot id: G7MT04
uniprot id: H9ES29
names: Similarity
messages: Belongs to the cyclin family.

9544:NDST2
gene id: 9544:NDST2
uniprot id: A0A8J8XW43
uniprot id: G7N251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9544:CLDN25
gene id: 9544:CLDN25
uniprot id: A0A5F8AI58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9544:MAPT
gene id: 9544:MAPT
uniprot id: A0A5F8A774
uniprot id: F6R387
uniprot id: P57786
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in neurons.
messages: Interacts with MARK1, MARK2, MARK3 and MARK4 (By similarity). Interacts with SQSTM1 when polyubiquitinated (By similarity). Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with FKBP4 (By similarity). Binds to CSNK1D (By similarity). Interacts with SGK1 (By similarity). Interacts with PIN1 (By similarity). Interacts with LRRK2 (By similarity). Interacts with LRP1, leading to endocytosis; this interaction is reduced in the presence of LRPAP1/RAP (By similarity).
messages: Membrane
messages: Phosphorylation at various serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1, CDK1, CDK5, GSK3, MAPK) (a few sites per protein in interphase, more in mitosis), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1, MARK2, MARK3 or MARK4), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation at Ser-280 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated by PHK. Dephosphorylation at several serine and threonine residues by the serine/threonine phosphatase PPP5C (By similarity).
messages: Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By similarity).
messages: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
messages: Secreted
messages: The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.
messages: axon
messages: cytoskeleton
messages: cytosol
messages: dendrite

9544:EID2
gene id: 9544:EID2
uniprot id: H9H5I6
names: Subcellular Location Annotation
messages: Nucleus

9544:TIE1
gene id: 9544:TIE1
uniprot id: A0A8J8XCU7
uniprot id: G7MGE5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:NOVA1
gene id: 9544:NOVA1
uniprot id: F6ZSR6
uniprot id: H9FUY0
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus

9544:LOC702514
gene id: 9544:LOC702514
uniprot id: F6TJQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9544:VKORC1
gene id: 9544:VKORC1
uniprot id: I0FMS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ATXN1L
gene id: 9544:ATXN1L
uniprot id: I2CWX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9544:TEX10
gene id: 9544:TEX10
uniprot id: A0A1D5R8M0
uniprot id: A0A8J8Y953
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9544:LYPLAL1
gene id: 9544:LYPLAL1
uniprot id: F7CPP0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9544:C2
gene id: 9544:C2
uniprot id: A0A8J8XKY4
uniprot id: F6YK65
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:ZKSCAN2
gene id: 9544:ZKSCAN2
uniprot id: F7BNI9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9544:RPS6KA3
gene id: 9544:RPS6KA3
uniprot id: F7B501
uniprot id: H9ZC41
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9544:TCP10
gene id: 9544:TCP10
uniprot id: F7ASH3
names: Similarity
messages: Belongs to the TCP10 family.

9544:SOHLH1
gene id: 9544:SOHLH1
uniprot id: A0A5F8ABF0
names: Subcellular Location Annotation
messages: Nucleus

9544:POLG
gene id: 9544:POLG
uniprot id: F6VGG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

9544:ALG6
gene id: 9544:ALG6
uniprot id: F6XRM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:MRPL9
gene id: 9544:MRPL9
uniprot id: A0A8J8XKV3
uniprot id: F7EDQ0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

9544:GNB1
gene id: 9544:GNB1
uniprot id: A0A8J8XZ61
uniprot id: F7FXA9
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9544:PRR5L
gene id: 9544:PRR5L
uniprot id: A0A5F7ZG00
names: Similarity
messages: Belongs to the PROTOR family.

9544:ZWILCH
gene id: 9544:ZWILCH
uniprot id: A0A5K1ULI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
messages: kinetochore

9544:ATP6V0C
gene id: 9544:ATP6V0C
uniprot id: F6QD23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9544:TSPAN5
gene id: 9544:TSPAN5
uniprot id: A0A1D5REZ6
uniprot id: A0A5F8AB78
uniprot id: A0A8J8Y5J5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CYGB
gene id: 9544:CYGB
uniprot id: H9FPJ4
names: Similarity
messages: Belongs to the globin family.

9544:DOK1
gene id: 9544:DOK1
uniprot id: A0A8J8XZH0
uniprot id: G7NAF3
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9544:DMRTA2
gene id: 9544:DMRTA2
uniprot id: A0A5F7ZPU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9544:HIF1A
gene id: 9544:HIF1A
uniprot id: H9ET32
uniprot id: H9YWK2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle

9544:GTF2F1
gene id: 9544:GTF2F1
uniprot id: A0A1D5R7P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

9544:TBC1D31
gene id: 9544:TBC1D31
uniprot id: A0A1D5Q0R3
uniprot id: F7H8T4
names: Function
names: Subcellular Location Annotation
messages: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
messages: centriolar satellite
messages: cilium basal body

9544:EML1
gene id: 9544:EML1
uniprot id: F7HCC0
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9544:C1D
gene id: 9544:C1D
uniprot id: F7HGG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9544:NT5E
gene id: 9544:NT5E
uniprot id: A0A8J8YQL6
uniprot id: F7GPZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9544:TPM4
gene id: 9544:TPM4
uniprot id: A0A5F8AC84
uniprot id: H9END9
uniprot id: I0FUR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9544:UBAP2L
gene id: 9544:UBAP2L
uniprot id: F7GQI0
uniprot id: F7GRU3
names: Subcellular Location Annotation
messages: Cytoplasm

9544:ENTPD7
gene id: 9544:ENTPD7
uniprot id: F7HAL5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9544:VGLL2
gene id: 9544:VGLL2
uniprot id: A0A1D5QQ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9544:FDXR
gene id: 9544:FDXR
uniprot id: H9YWH2
uniprot id: I2CWN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

9544:IL7R
gene id: 9544:IL7R
uniprot id: A0A1D5QDM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

9544:SLC25A51
gene id: 9544:SLC25A51
uniprot id: F7F3D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:APEX1
gene id: 9544:APEX1
uniprot id: A0A8J8XNV0
uniprot id: F7GIK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9544:FAM163B
gene id: 9544:FAM163B
uniprot id: A0A8J8XAE4
uniprot id: F7HGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9544:EIF1AY
gene id: 9544:EIF1AY
uniprot id: B8YE01
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

9544:RRS1
gene id: 9544:RRS1
uniprot id: A0A8J8YPV7
uniprot id: F6T893
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9544:AGK
gene id: 9544:AGK
uniprot id: I0FJR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9544:SOD1
gene id: 9544:SOD1
uniprot id: H9FMP4
uniprot id: Q8HXQ0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer; non-disulfide-linked (By similarity). Heterodimer with SOD1. The heterodimer CCS:SOD1 interacts with SLC31A1; this heterotrimer is Cu(1+)-mediated and its maintenance is regulated through SOD1 activation (By similarity).
messages: Nucleus
messages: Palmitoylation helps nuclear targeting and decreases catalytic activity.
messages: Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity.

9544:ICAM4
gene id: 9544:ICAM4
uniprot id: F7HJJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9544:TRAF6
gene id: 9544:TRAF6
uniprot id: B6CJY5
uniprot id: F7HMD7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Cytoplasm
messages: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN (By similarity). Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (By similarity). Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Participates also in the TCR signaling by ubiquitinating LAT (By similarity).
messages: Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK2, IRAK3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI2 and PELI3. Binds UBE2V1. Interacts with TAX1BP1; this interaction mediates deubiquitination of TRAF6 and inhibition of NF-kappa-B activation (By similarity). Interacts with ZNF675. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts with RBCK1. Interacts with LIMD1 (via LIM domains) (By similarity). Interacts with RSAD2/viperin (By similarity). Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity). Interacts with ZFAND5. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with AJUBA. Interacts with MAVS/IPS1. Interacts (via TRAF domains) with DYNC2I2 (via WD domains). Interacts with IFIT3 (via N-terminus). Interacts with TICAM2. Interacts with CARD14. Interacts with CD40 and MAP3K8; the interaction is required for ERK activation (By similarity). Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1. Interacts with TANK; this interaction increases in response to DNA damage. Interacts with USP…
messages: Lipid droplet
messages: Nucleus
messages: Polyubiquitinated on Lys-124 by TRAF3IP2; after cell stimulation with IL17A (By similarity). Polyubiquitinated; after cell stimulation with IL1B or TGFB. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage. LRRC19 induces 'Lys-63' ubiquitination (By similarity). Ubiquitinated at Lys-319 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (By similarity).
messages: Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.
messages: The MATH/TRAF domain binds to receptor cytoplasmic domains.
messages: The coiled coil domain mediates homo- and hetero-oligomerization.
messages: cell cortex

9544:PPP1R1A
gene id: 9544:PPP1R1A
uniprot id: A0A8J8XGA7
uniprot id: F7H8B4
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9544:MEGF9
gene id: 9544:MEGF9
uniprot id: F7C0W7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:MMAA
gene id: 9544:MMAA
uniprot id: F7GUL5
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

9544:ZFY
gene id: 9544:ZFY
uniprot id: B8YE14
names: Subcellular Location Annotation
messages: Nucleus

9544:TCEA2
gene id: 9544:TCEA2
uniprot id: H9FZ10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9544:APOA2
gene id: 9544:APOA2
uniprot id: A0A8J8XNR3
uniprot id: F6SD23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein A2 family.
messages: Secreted

9544:SYPL1
gene id: 9544:SYPL1
uniprot id: F7B9I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9544:MPV17L2
gene id: 9544:MPV17L2
uniprot id: F7ASV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9544:CD164L2
gene id: 9544:CD164L2
uniprot id: F7HFD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9544:FUBP1
gene id: 9544:FUBP1
uniprot id: H9G1C9
names: Subcellular Location Annotation
messages: Nucleus

9544:ALG12
gene id: 9544:ALG12
uniprot id: F6WHE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ENY2
gene id: 9544:ENY2
uniprot id: F7B6X1
uniprot id: H9EQK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9544:CDY
gene id: 9544:CDY
uniprot id: B8YDZ8
names: Subcellular Location Annotation
messages: Nucleus

9544:FLOT1
gene id: 9544:FLOT1
uniprot id: A0A8J8Y099
uniprot id: G7MRG3
uniprot id: Q5TM70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Melanosome
messages: Membrane
messages: Membrane raft
messages: caveola

9544:GPRIN2
gene id: 9544:GPRIN2
uniprot id: F6YNR6
names: Function
messages: May be involved in neurite outgrowth.

9544:FAM76B
gene id: 9544:FAM76B
uniprot id: A0A8J8XR52
uniprot id: F6WCW5
names: Similarity
messages: Belongs to the FAM76 family.

9544:DEFA1B
gene id: 9544:DEFA1B
uniprot id: P60030
uniprot id: Q9TTZ9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.
messages: Belongs to the alpha-defensin family.
messages: Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs. Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis. Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry. In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release. Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs.
messages: Secreted
messages: Tetramer. Dimer. Interacts with RETN.

9544:RFC2
gene id: 9544:RFC2
uniprot id: A0A8J8XRZ4
uniprot id: F7HAF1
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9544:EDIL3
gene id: 9544:EDIL3
uniprot id: A0A1D5RFH0
uniprot id: A0A8J8XRE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:DDX41
gene id: 9544:DDX41
uniprot id: A0A5K1V204
uniprot id: A0A8J8XK61
uniprot id: G7MUG5
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

9544:ADORA1
gene id: 9544:ADORA1
uniprot id: F7E1N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9544:NPRL2
gene id: 9544:NPRL2
uniprot id: A0A8J8XP93
uniprot id: G7ML64
names: Similarity
messages: Belongs to the NPR2 family.

9544:IKBKB
gene id: 9544:IKBKB
uniprot id: A0A8J8XBD7
uniprot id: F6SHC1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:CCT4
gene id: 9544:CCT4
uniprot id: H9FNT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9544:LOC705546
gene id: 9544:LOC705546
uniprot id: H9FWM8
names: Similarity
messages: Belongs to the CBP3 family.

9544:LTBR
gene id: 9544:LTBR
uniprot id: A0A1D5QP89
uniprot id: F6V995
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:KCNJ13
gene id: 9544:KCNJ13
uniprot id: A0A5F7ZVU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:ACKR2
gene id: 9544:ACKR2
uniprot id: G7MIX5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane
messages: Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

9544:HTR1D
gene id: 9544:HTR1D
uniprot id: A0A8J8YQ68
uniprot id: F7FW05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9544:RGS4
gene id: 9544:RGS4
uniprot id: A0A663DBJ0
uniprot id: F7CYN6
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9544:CDK10
gene id: 9544:CDK10
uniprot id: A0A8J8YM25
uniprot id: G7NQA5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:ANP32A
gene id: 9544:ANP32A
uniprot id: A0A8J8XQX6
uniprot id: G7MY28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9544:SFXN5
gene id: 9544:SFXN5
uniprot id: A0A1D5R390
uniprot id: A0A8J8YEG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9544:SCN3B
gene id: 9544:SCN3B
uniprot id: A0A8J8YSM2
uniprot id: G7NCM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9544:MARVELD1
gene id: 9544:MARVELD1
uniprot id: H9H444
names: Subcellular Location Annotation
messages: Membrane

9544:SERPINA11
gene id: 9544:SERPINA11
uniprot id: A0A8J8XTW2
uniprot id: F7EJG1
names: Similarity
messages: Belongs to the serpin family.

9544:GNL2
gene id: 9544:GNL2
uniprot id: F6VCJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9544:SPACA5
gene id: 9544:SPACA5
uniprot id: A0A8J8Y1Z0
uniprot id: F7FWH5
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9544:SERPINB9
gene id: 9544:SERPINB9
uniprot id: A0A8J8YRL9
uniprot id: F7HA35
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9544:PHF19
gene id: 9544:PHF19
uniprot id: A0A1D5QU71
uniprot id: A0A8J8YIB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9544:EGFL7
gene id: 9544:EGFL7
uniprot id: F7GSK3
uniprot id: H9FVA9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:C18H18orf21
gene id: 9544:C18H18orf21
uniprot id: G7NKL6
names: Similarity
messages: Belongs to the UPF0711 family.

9544:MEF2A
gene id: 9544:MEF2A
uniprot id: F7FGB3
uniprot id: H9FUJ3
uniprot id: H9FUJ5
uniprot id: H9FUJ6
names: Subcellular Location Annotation
messages: Nucleus

9544:IMPDH2
gene id: 9544:IMPDH2
uniprot id: A0A8J8XMN3
uniprot id: F6VXT4
uniprot id: H9YWM9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9544:IDO1
gene id: 9544:IDO1
uniprot id: F6SGT6
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9544:CELF3
gene id: 9544:CELF3
uniprot id: F7CBU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

9544:NAMPT
gene id: 9544:NAMPT
uniprot id: H9EW35
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

9544:LACC1
gene id: 9544:LACC1
uniprot id: F6UMP1
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9544:POLR3A
gene id: 9544:POLR3A
uniprot id: A0A8J8YSJ6
uniprot id: G7N235
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9544:RPP21
gene id: 9544:RPP21
uniprot id: Q5TM57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA.
messages: nucleolus

9544:PSMB2
gene id: 9544:PSMB2
uniprot id: A0A8J8XXX8
uniprot id: F6XJL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9544:NUTF2
gene id: 9544:NUTF2
uniprot id: H9EQR2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9544:ALDH1A3
gene id: 9544:ALDH1A3
uniprot id: F7H3Z2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:TMEM237
gene id: 9544:TMEM237
uniprot id: H9FYM3
uniprot id: H9FYM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9544:CHN2
gene id: 9544:CHN2
uniprot id: A0A1D5QMR4
uniprot id: F6VWF7
uniprot id: H9ETX3
names: Function
messages: GTPase-activating protein for p21-rac.

9544:BRF1
gene id: 9544:BRF1
uniprot id: F6RDQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIB family.
messages: Nucleus

9544:CPM
gene id: 9544:CPM
uniprot id: G7N7L7
names: Similarity
messages: Belongs to the peptidase M14 family.

9544:RLN3
gene id: 9544:RLN3
uniprot id: A0A5F7ZQJ4
uniprot id: A2CHN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9544:LAPTM4A
gene id: 9544:LAPTM4A
uniprot id: A0A8J8YC21
uniprot id: F7GV77
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9544:TVP23A
gene id: 9544:TVP23A
uniprot id: H9FZL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9544:ASF1A
gene id: 9544:ASF1A
uniprot id: F6WJH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9544:OLFM2
gene id: 9544:OLFM2
uniprot id: A0A1D5QCB9
uniprot id: F6U4R3
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9544:STAMBP
gene id: 9544:STAMBP
uniprot id: A0A8J8Y8Y0
uniprot id: G7NAC8
names: Similarity
messages: Belongs to the peptidase M67C family.

9544:CDC26
gene id: 9544:CDC26
uniprot id: A0A8J8YSZ2
uniprot id: F6VD10
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9544:CCL20
gene id: 9544:CCL20
uniprot id: Q8HYP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:KCNMB1
gene id: 9544:KCNMB1
uniprot id: A0A8J8Y6X7
uniprot id: F6ZEE8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9544:TMEM87A
gene id: 9544:TMEM87A
uniprot id: A0A8J8Y0B0
uniprot id: F7GAX2
names: Subcellular Location Annotation
messages: Membrane

9544:CRYAA
gene id: 9544:CRYAA
uniprot id: P02488
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-70 may increase chaperone activity.
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
messages: Cytoplasm
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers. Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.
messages: Nucleus
messages: Undergoes age-dependent proteolytical cleavage at the C-terminus.

9544:YAE1
gene id: 9544:YAE1
uniprot id: G7MLG1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:LEF1
gene id: 9544:LEF1
uniprot id: A0A1D5Q829
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9544:CHMP4B
gene id: 9544:CHMP4B
uniprot id: H9FPW6
names: Similarity
messages: Belongs to the SNF7 family.

9544:TADA1
gene id: 9544:TADA1
uniprot id: A0A8J8YM27
uniprot id: F7ETZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9544:B3GALT4
gene id: 9544:B3GALT4
uniprot id: H9ZES3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:SV2A
gene id: 9544:SV2A
uniprot id: A0A8J8YL29
uniprot id: G7MGF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9544:LRRFIP2
gene id: 9544:LRRFIP2
uniprot id: A0A8J8XWJ0
uniprot id: G7MJ23
uniprot id: H9EPE5
uniprot id: H9EUI0
names: Similarity
messages: Belongs to the LRRFIP family.

9544:CYB5R4
gene id: 9544:CYB5R4
uniprot id: A0A1D5REY0
uniprot id: A0A8J8YGS5
uniprot id: G7MPU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9544:GRID2
gene id: 9544:GRID2
uniprot id: F7BZZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:MSTN
gene id: 9544:MSTN
uniprot id: A1C2U6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted
messages: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

9544:PPP1CA
gene id: 9544:PPP1CA
uniprot id: F7GWK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9544:FZD5
gene id: 9544:FZD5
uniprot id: A0A5F8AQY2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:TM2D2
gene id: 9544:TM2D2
uniprot id: A0A8J8XY28
uniprot id: F6WJ17
names: Subcellular Location Annotation
messages: Membrane

9544:LOC704659
gene id: 9544:LOC704659
uniprot id: G7MN45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9544:SLC39A14
gene id: 9544:SLC39A14
uniprot id: A0A1D5Q778
uniprot id: A0A1D5RIG3
uniprot id: F6U2Z9
names: Subcellular Location Annotation
messages: Membrane

9544:TRPC4
gene id: 9544:TRPC4
uniprot id: A0A1D5QA06
names: Subcellular Location Annotation
messages: Membrane

9544:MT1A
gene id: 9544:MT1A
uniprot id: H9FUP3
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:ITGB8
gene id: 9544:ITGB8
uniprot id: A0A8J8XTV8
uniprot id: H9FU34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9544:NPL
gene id: 9544:NPL
uniprot id: A0A1D5QL39
uniprot id: G7MF42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9544:OSM
gene id: 9544:OSM
uniprot id: F7GF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: Secreted

9544:NCL
gene id: 9544:NCL
uniprot id: H9H3Z4
names: Function
names: Subcellular Location Annotation
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
messages: nucleolus

9544:MB21D2
gene id: 9544:MB21D2
uniprot id: A0A8J8XZ51
uniprot id: F7GLU3
names: Similarity
messages: Belongs to the mab-21 family.

9544:SLC12A2
gene id: 9544:SLC12A2
uniprot id: F6WYA8
uniprot id: H9FYQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9544:LCN10
gene id: 9544:LCN10
uniprot id: F7GSI9
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9544:EIF3K
gene id: 9544:EIF3K
uniprot id: A0A8J8Y4M4
uniprot id: F6XGZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9544:AQP9
gene id: 9544:AQP9
uniprot id: A0A8J8XHM0
uniprot id: F6WY03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9544:ACSL1
gene id: 9544:ACSL1
uniprot id: A0A8J8XRJ5
uniprot id: G7MSE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9544:MOB3B
gene id: 9544:MOB3B
uniprot id: A0A8J8Y322
uniprot id: G7NFP7
names: Similarity
messages: Belongs to the MOB1/phocein family.

9544:TIMM8A
gene id: 9544:TIMM8A
uniprot id: F7BGN5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9544:IQCG
gene id: 9544:IQCG
uniprot id: A0A5F7ZHE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9544:SEPTIN9
gene id: 9544:SEPTIN9
uniprot id: H9EV03
uniprot id: I2CTF1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9544:LOC700258
gene id: 9544:LOC700258
uniprot id: F7HMY6
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9544:IL33
gene id: 9544:IL33
uniprot id: F7DLG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9544:HNRNPF
gene id: 9544:HNRNPF
uniprot id: A0A8J8XK70
uniprot id: F6UEF5
names: Subcellular Location Annotation
messages: nucleoplasm

9544:CERS4
gene id: 9544:CERS4
uniprot id: F6V9L6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9544:ADI1
gene id: 9544:ADI1
uniprot id: F6QS54
uniprot id: H9FWN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

9544:CSTF3
gene id: 9544:CSTF3
uniprot id: A0A1D5QQW9
names: Subcellular Location Annotation
messages: Nucleus

9544:PAQR5
gene id: 9544:PAQR5
uniprot id: A0A8J8XI78
uniprot id: G7MY33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9544:FOXM1
gene id: 9544:FOXM1
uniprot id: F6T2H2
uniprot id: H9YYX7
names: Subcellular Location Annotation
messages: Nucleus

9544:RBFOX3
gene id: 9544:RBFOX3
uniprot id: A0A5F8AJA2
uniprot id: H9EP63
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9544:ACTL7A
gene id: 9544:ACTL7A
uniprot id: G7NEK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

9544:TRAPPC2L
gene id: 9544:TRAPPC2L
uniprot id: I2CX67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9544:ISOC1
gene id: 9544:ISOC1
uniprot id: H9ESJ6
names: Similarity
messages: Belongs to the isochorismatase family.

9544:RXFP4
gene id: 9544:RXFP4
uniprot id: A0A8J8YAA0
uniprot id: F6U984
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:TTC9
gene id: 9544:TTC9
uniprot id: A0A5F7ZGX8
names: Similarity
messages: Belongs to the TTC9 family.

9544:GNAI1
gene id: 9544:GNAI1
uniprot id: H9EPA7
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:AMOT
gene id: 9544:AMOT
uniprot id: F6WTL5
names: Similarity
messages: Belongs to the angiomotin family.

9544:HOXC8
gene id: 9544:HOXC8
uniprot id: A0A8J8Y4X7
uniprot id: F6R6W9
names: Subcellular Location Annotation
messages: Nucleus

9544:LGI1
gene id: 9544:LGI1
uniprot id: A0A5F7ZTH0
uniprot id: A0A8J8YRR8
uniprot id: F7GS70
names: Subcellular Location Annotation
messages: Secreted

9544:SST
gene id: 9544:SST
uniprot id: A0A8J8XAE3
uniprot id: F6TGD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9544:TLE1
gene id: 9544:TLE1
uniprot id: A0A1D5Q377
uniprot id: A0A5K1VAB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9544:MMD
gene id: 9544:MMD
uniprot id: H9EMI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9544:ETV6
gene id: 9544:ETV6
uniprot id: A0A8J8XX95
uniprot id: G7N675
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:DUSP6
gene id: 9544:DUSP6
uniprot id: A0A8J8Y6L4
uniprot id: G7N7X5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9544:BHLHB9
gene id: 9544:BHLHB9
uniprot id: F7FA72
names: Similarity
messages: Belongs to the GPRASP family.

9544:MRPL33
gene id: 9544:MRPL33
uniprot id: F7FM50
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9544:MTG2
gene id: 9544:MTG2
uniprot id: A0A5K1U680
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9544:IZUMO1
gene id: 9544:IZUMO1
uniprot id: A0A8J8Y0H1
uniprot id: F6XH82
names: Similarity
messages: Belongs to the Izumo family.

9544:NCOA2
gene id: 9544:NCOA2
uniprot id: A0A5F8AQQ8
uniprot id: H9ET70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9544:PKM
gene id: 9544:PKM
uniprot id: F7FI45
uniprot id: I0FSN6
names: Similarity
messages: Belongs to the pyruvate kinase family.

9544:EPGN
gene id: 9544:EPGN
uniprot id: A0A8J8Y2N5
uniprot id: F7AEA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:FEZ1
gene id: 9544:FEZ1
uniprot id: A0A1D5RD14
uniprot id: A0A8J8XCR2
names: Similarity
messages: Belongs to the zygin family.

9544:NFYB
gene id: 9544:NFYB
uniprot id: A0A1D5Q0C9
uniprot id: F6ZKY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9544:GPSM1
gene id: 9544:GPSM1
uniprot id: I2CVY9
names: Similarity
messages: Belongs to the GPSM family.

9544:AIDA
gene id: 9544:AIDA
uniprot id: H9FYK5
names: Similarity
messages: Belongs to the AIDA family.

9544:TEC
gene id: 9544:TEC
uniprot id: A0A8J8Y2H2
uniprot id: G7MSV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9544:NT5DC2
gene id: 9544:NT5DC2
uniprot id: F7H8Z8
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9544:GSTM3
gene id: 9544:GSTM3
uniprot id: A0A8J8XGH4
uniprot id: F7H5D7
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9544:IFI27L2
gene id: 9544:IFI27L2
uniprot id: A0A8J8XT25
uniprot id: G7MW21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9544:PHYHIPL
gene id: 9544:PHYHIPL
uniprot id: A0A5F7ZJK7
uniprot id: H9EM71
names: Similarity
messages: Belongs to the PHYHIP family.

9544:ZDHHC2
gene id: 9544:ZDHHC2
uniprot id: F7GMT9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:ALOX5
gene id: 9544:ALOX5
uniprot id: A0A1D5QJX2
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:ARFGEF1
gene id: 9544:ARFGEF1
uniprot id: I0FNI6
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9544:CNOT8
gene id: 9544:CNOT8
uniprot id: A0A1D5R1V6
uniprot id: A0A8J8XE87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9544:NLE1
gene id: 9544:NLE1
uniprot id: A0A1D5R0W2
names: Subcellular Location Annotation
messages: nucleolus

9544:TYW3
gene id: 9544:TYW3
uniprot id: H9FPV5
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9544:TMEM45B
gene id: 9544:TMEM45B
uniprot id: A0A8J8YBE6
uniprot id: F6UKU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9544:MCRIP2
gene id: 9544:MCRIP2
uniprot id: F6Z225
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9544:CASTOR1
gene id: 9544:CASTOR1
uniprot id: A0A8J8XFG4
uniprot id: F7GBS3
names: Similarity
messages: Belongs to the GATS family.

9544:RPN1
gene id: 9544:RPN1
uniprot id: Q3YAI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9544:MS4A1
gene id: 9544:MS4A1
uniprot id: A0A1D5QH81
names: Similarity
messages: Belongs to the MS4A family.

9544:SULT2B1
gene id: 9544:SULT2B1
uniprot id: F7H354
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9544:ACD
gene id: 9544:ACD
uniprot id: F6XSB4
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9544:GPRC5A
gene id: 9544:GPRC5A
uniprot id: A0A5F8ALP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:NDUFC1
gene id: 9544:NDUFC1
uniprot id: A0A8J8YE66
uniprot id: F7EDI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:C10H20orf24
gene id: 9544:C10H20orf24
uniprot id: A0A5F8ABP4
uniprot id: A0A8J8XS53
uniprot id: F7GYH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:AVL9
gene id: 9544:AVL9
uniprot id: H9FRN4
names: Subcellular Location Annotation
messages: Recycling endosome

9544:FAM32A
gene id: 9544:FAM32A
uniprot id: A0A8J8Y868
uniprot id: G7NMP1
names: Similarity
messages: Belongs to the FAM32 family.

9544:HCN3
gene id: 9544:HCN3
uniprot id: A0A5F8AQA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9544:UBE2F
gene id: 9544:UBE2F
uniprot id: F6X242
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:POLR3G
gene id: 9544:POLR3G
uniprot id: F6Y5L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9544:HBA
gene id: 9544:HBA
uniprot id: P63108
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9544:TMEM129
gene id: 9544:TMEM129
uniprot id: H9ZFC4
uniprot id: I0FWD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9544:PLCG1
gene id: 9544:PLCG1
uniprot id: A0A1D5R8E9
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9544:PXMP4
gene id: 9544:PXMP4
uniprot id: A0A8J8XPV6
uniprot id: G7N517
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9544:FOXS1
gene id: 9544:FOXS1
uniprot id: A0A8J8YB75
uniprot id: G7N548
names: Subcellular Location Annotation
messages: Nucleus

9544:ARF4
gene id: 9544:ARF4
uniprot id: A0A1D5RH41
uniprot id: I0FRJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9544:CLDN18
gene id: 9544:CLDN18
uniprot id: A0A8J8XC18
uniprot id: F6YQY3
uniprot id: F6YQZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9544:COPZ1
gene id: 9544:COPZ1
uniprot id: I0FQ09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9544:HAMP
gene id: 9544:HAMP
uniprot id: A0A8J8XF93
uniprot id: F6WA25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9544:THRAP3
gene id: 9544:THRAP3
uniprot id: A0A5F8ADF5
uniprot id: F7GNF6
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9544:CYP4V2
gene id: 9544:CYP4V2
uniprot id: H9EWH9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:SIM1
gene id: 9544:SIM1
uniprot id: A0A8J8YN00
uniprot id: F6X815
names: Subcellular Location Annotation
messages: Nucleus

9544:ATP6V1E1
gene id: 9544:ATP6V1E1
uniprot id: A0A1D5RKC1
uniprot id: H9FVU4
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9544:TNFAIP6
gene id: 9544:TNFAIP6
uniprot id: A0A8J8XCS1
uniprot id: F7GLN3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CMC4
gene id: 9544:CMC4
uniprot id: A0A8J8XD19
uniprot id: F6QM91
names: Similarity
messages: Belongs to the CMC4 family.

9544:OSGEPL1
gene id: 9544:OSGEPL1
uniprot id: A0A8J8XYH5
uniprot id: G7N8H8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9544:TRIM10
gene id: 9544:TRIM10
uniprot id: Q5TM54
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:DEFB123
gene id: 9544:DEFB123
uniprot id: G7N558
uniprot id: Q5J5D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant expression in the male reproductive tract only. Expressed abundantly in testis, while expression in epididymis decreased gradually from caput to cauda.
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:ITGB4
gene id: 9544:ITGB4
uniprot id: F7DF99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9544:MFSD11
gene id: 9544:MFSD11
uniprot id: A0A8J8XH28
uniprot id: G7NGZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9544:YY1
gene id: 9544:YY1
uniprot id: H9YYS6
names: Similarity
messages: Belongs to the YY transcription factor family.

9544:AMER2
gene id: 9544:AMER2
uniprot id: F7HQM9
names: Similarity
messages: Belongs to the Amer family.

9544:BOD1
gene id: 9544:BOD1
uniprot id: F6TDI5
uniprot id: H9EQV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

9544:CNOT1
gene id: 9544:CNOT1
uniprot id: F7GNE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9544:GCNT1
gene id: 9544:GCNT1
uniprot id: A0A8J8YHX1
uniprot id: F6U1S7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9544:DGKZ
gene id: 9544:DGKZ
uniprot id: A0A1D5R745
uniprot id: A0A1D5RBV3
uniprot id: H9G116
uniprot id: I2CU98
uniprot id: I2CUS8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9544:MTERF1
gene id: 9544:MTERF1
uniprot id: A0A5F8AK76
uniprot id: A0A8J8YR68
uniprot id: H9FZW3
names: Similarity
messages: Belongs to the mTERF family.

9544:GRK5
gene id: 9544:GRK5
uniprot id: A0A5K1VNZ0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9544:ADD2
gene id: 9544:ADD2
uniprot id: A0A8J8XAA6
uniprot id: F7CGX1
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9544:CBFA2T3
gene id: 9544:CBFA2T3
uniprot id: A0A5F7ZYF2
uniprot id: A0A5F8AB43
names: Similarity
messages: Belongs to the CBFA2T family.

9544:BEND6
gene id: 9544:BEND6
uniprot id: A0A8J8YQ56
uniprot id: G7MPN2
names: Subcellular Location Annotation
messages: Nucleus

9544:BBS5
gene id: 9544:BBS5
uniprot id: A0A5F8A0K9
uniprot id: H9Z224
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9544:GNB2
gene id: 9544:GNB2
uniprot id: H9Z7W5
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9544:EIF1AX
gene id: 9544:EIF1AX
uniprot id: H9EP53
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

9544:SPTLC2
gene id: 9544:SPTLC2
uniprot id: A0A1D5Q2N7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9544:TNP1
gene id: 9544:TNP1
uniprot id: A0A8J8XN41
uniprot id: F7VJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Chromosome
messages: Nucleus

9544:MZT1
gene id: 9544:MZT1
uniprot id: A0A8J8XC33
uniprot id: G7NJF0
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9544:GDPD3
gene id: 9544:GDPD3
uniprot id: F6SYN2
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9544:TAT
gene id: 9544:TAT
uniprot id: A0A8J8XCN5
uniprot id: F6TMN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9544:NDUFS4
gene id: 9544:NDUFS4
uniprot id: A0A8J8XAH3
uniprot id: F7AVF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9544:HOXA1
gene id: 9544:HOXA1
uniprot id: A0A8J8YAA6
uniprot id: F6Q6A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9544:FAM76A
gene id: 9544:FAM76A
uniprot id: A0A1D5QXM5
uniprot id: F6V7A1
names: Similarity
messages: Belongs to the FAM76 family.

9544:LOC718280
gene id: 9544:LOC718280
uniprot id: A0A8J8XWP1
uniprot id: F7HPR3
names: Similarity
messages: Belongs to the histone H3 family.

9544:C6H5orf24
gene id: 9544:C6H5orf24
uniprot id: A0A5F7Z8Q3
uniprot id: A0A8J8YSB0
uniprot id: F6XPU3
names: Similarity
messages: Belongs to the UPF0461 family.

9544:LOXL3
gene id: 9544:LOXL3
uniprot id: F6Y815
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9544:CPXM2
gene id: 9544:CPXM2
uniprot id: F6W9K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9544:LOC100424989
gene id: 9544:LOC100424989
uniprot id: A0A1D5RE48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:KRT39
gene id: 9544:KRT39
uniprot id: F7GFM5
names: Similarity
messages: Belongs to the intermediate filament family.

9544:GJC2
gene id: 9544:GJC2
uniprot id: F6URR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:HOXB7
gene id: 9544:HOXB7
uniprot id: F7HN76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:ORC3
gene id: 9544:ORC3
uniprot id: H9FS88
uniprot id: I0FI50
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

9544:CBLC
gene id: 9544:CBLC
uniprot id: A0A5F8AHX9
uniprot id: A0A8J8XPX7
uniprot id: F7FKP6
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9544:PARL
gene id: 9544:PARL
uniprot id: H9EWC9
names: Subcellular Location Annotation
messages: Membrane

9544:RHOT2
gene id: 9544:RHOT2
uniprot id: I2CTJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9544:XRN2
gene id: 9544:XRN2
uniprot id: H9FRE3
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9544:ACTR3
gene id: 9544:ACTR3
uniprot id: H9FNE9
names: Similarity
messages: Belongs to the actin family.

9544:ZNF280A
gene id: 9544:ZNF280A
uniprot id: F7BSG4
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9544:TRNAU1AP
gene id: 9544:TRNAU1AP
uniprot id: F7HRU6
uniprot id: H9EQN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9544:CEBPZ
gene id: 9544:CEBPZ
uniprot id: F7GTT7
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9544:FGF13
gene id: 9544:FGF13
uniprot id: A0A1D5QTA0
uniprot id: F7FB49
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:ACAT2
gene id: 9544:ACAT2
uniprot id: F6TAZ6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9544:CRYGN
gene id: 9544:CRYGN
uniprot id: A0A8J8YQT6
uniprot id: F7H5C8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9544:SLC27A4
gene id: 9544:SLC27A4
uniprot id: A0A8J8YRX1
uniprot id: G7NFS5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:CDH2
gene id: 9544:CDH2
uniprot id: F6WI86
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:PGAP2
gene id: 9544:PGAP2
uniprot id: F6ZFL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9544:STOML2
gene id: 9544:STOML2
uniprot id: A0A8J8YD82
uniprot id: G7NFE6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9544:CHN1
gene id: 9544:CHN1
uniprot id: F7ET58
names: Function
messages: GTPase-activating protein for p21-rac.

9544:NSFL1C
gene id: 9544:NSFL1C
uniprot id: F6XMH7
uniprot id: I0FG44
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9544:LOC700087
gene id: 9544:LOC700087
uniprot id: G7NLE4
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9544:PKMYT1
gene id: 9544:PKMYT1
uniprot id: F6Z3J0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:HTR2B
gene id: 9544:HTR2B
uniprot id: F7HQF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9544:ODF2
gene id: 9544:ODF2
uniprot id: F7HTS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9544:RC3H2
gene id: 9544:RC3H2
uniprot id: A0A1D5REV0
uniprot id: F7HDA8
names: Subcellular Location Annotation
messages: P-body

9544:ATP1B2
gene id: 9544:ATP1B2
uniprot id: A0A8J8XTI3
uniprot id: G7NIG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9544:CMTM2
gene id: 9544:CMTM2
uniprot id: A0A8J8XXK9
uniprot id: F6RFF0
names: Subcellular Location Annotation
messages: Membrane

9544:LOC107000794
gene id: 9544:LOC107000794
uniprot id: F7AE93
names: Similarity
messages: Belongs to the LCE family.

9544:AK5
gene id: 9544:AK5
uniprot id: A0A5F8A002
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9544:UHRF2
gene id: 9544:UHRF2
uniprot id: A0A5F8ASM0
uniprot id: H9ET07
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

9544:PFDN2
gene id: 9544:PFDN2
uniprot id: A0A8J8XNV2
uniprot id: F6V169
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9544:NAA11
gene id: 9544:NAA11
uniprot id: A0A8J8XH26
uniprot id: F6U9M9
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9544:PGAM1
gene id: 9544:PGAM1
uniprot id: F7CUY7
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9544:CD55
gene id: 9544:CD55
uniprot id: A0A1D5R106
uniprot id: A0A5F8AN03
uniprot id: F7HC68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:EIF2B1
gene id: 9544:EIF2B1
uniprot id: H9ETU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9544:BSCL2
gene id: 9544:BSCL2
uniprot id: A0A5K1V2S6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ANO4
gene id: 9544:ANO4
uniprot id: A0A8J8XB24
uniprot id: F6YBZ5
uniprot id: H9EPZ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:NGFR
gene id: 9544:NGFR
uniprot id: F7GQ23
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:GPX5
gene id: 9544:GPX5
uniprot id: G7MRB6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9544:SLCO1C1
gene id: 9544:SLCO1C1
uniprot id: A0A1D5QL08
uniprot id: A0A5K1VTR2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:GSN
gene id: 9544:GSN
uniprot id: A0A1D5QT83
uniprot id: F7HB17
uniprot id: F7HP23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the villin/gelsolin family.
messages: Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR.
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
messages: cytoskeleton

9544:POLR3B
gene id: 9544:POLR3B
uniprot id: A0A8J8YNE0
uniprot id: F6WH42
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9544:HGS
gene id: 9544:HGS
uniprot id: H9ZF73
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
messages: multivesicular body membrane

9544:SLC25A22
gene id: 9544:SLC25A22
uniprot id: H9FZW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:CCDC126
gene id: 9544:CCDC126
uniprot id: A0A8J8YJW1
uniprot id: F6VKK5
names: Subcellular Location Annotation
messages: Secreted

9544:DDAH1
gene id: 9544:DDAH1
uniprot id: F7HB67
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9544:KALRN
gene id: 9544:KALRN
uniprot id: A0A1D5QWV4
uniprot id: F6VU49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm

9544:RPL41
gene id: 9544:RPL41
uniprot id: H9EP86
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit.

9544:BAIAP2
gene id: 9544:BAIAP2
uniprot id: H9ERK7
uniprot id: H9ERP2
uniprot id: H9YXW9
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9544:NOS3
gene id: 9544:NOS3
uniprot id: F6WEB2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

9544:TPI1
gene id: 9544:TPI1
uniprot id: H9ZD06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9544:IRX4
gene id: 9544:IRX4
uniprot id: F6Z379
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9544:NDP
gene id: 9544:NDP
uniprot id: A0A8J8XRP5
uniprot id: F7DMF6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:MTFR2
gene id: 9544:MTFR2
uniprot id: A0A8J8YQE0
uniprot id: F6S8Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9544:CCNE1
gene id: 9544:CCNE1
uniprot id: F7BEI4
names: Similarity
messages: Belongs to the cyclin family.

9544:ANXA4
gene id: 9544:ANXA4
uniprot id: A0A1D5R5Q6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

9544:LHFPL3
gene id: 9544:LHFPL3
uniprot id: H9FU60
names: Subcellular Location Annotation
messages: Membrane

9544:SETDB2
gene id: 9544:SETDB2
uniprot id: A0A8J8XZY7
uniprot id: G7NK50
names: Subcellular Location Annotation
messages: Chromosome

9544:TRIM46
gene id: 9544:TRIM46
uniprot id: F6TTN4
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

9544:RHOXF2
gene id: 9544:RHOXF2
uniprot id: F6TJC8
names: Subcellular Location Annotation
messages: Nucleus

9544:ESCO2
gene id: 9544:ESCO2
uniprot id: F7FUZ4
names: Subcellular Location Annotation
messages: Nucleus

9544:PNLIP
gene id: 9544:PNLIP
uniprot id: G7N172
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9544:DTX4
gene id: 9544:DTX4
uniprot id: F6PVK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9544:CCDC22
gene id: 9544:CCDC22
uniprot id: I0FR27
names: Similarity
messages: Belongs to the CCDC22 family.

9544:LHX4
gene id: 9544:LHX4
uniprot id: A0A8J8YRC4
uniprot id: G7MF58
names: Subcellular Location Annotation
messages: Nucleus

9544:RAD50
gene id: 9544:RAD50
uniprot id: F7DGI4
uniprot id: H9FNF3
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9544:AMD1
gene id: 9544:AMD1
uniprot id: H9EU24
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9544:MARK3
gene id: 9544:MARK3
uniprot id: A0A1D5QHC2
uniprot id: F6Q5Q2
uniprot id: H9FUG8
uniprot id: H9FUG9
uniprot id: H9FUH0
uniprot id: H9FUH1
uniprot id: H9YXQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9544:PKIB
gene id: 9544:PKIB
uniprot id: H9FWZ0
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9544:PSMB11
gene id: 9544:PSMB11
uniprot id: A0A8J8Y2G4
uniprot id: G7MX34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9544:INTS13
gene id: 9544:INTS13
uniprot id: H9FX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

9544:SLC6A7
gene id: 9544:SLC6A7
uniprot id: A0A8J8XNF5
uniprot id: F7BSV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9544:TRIM47
gene id: 9544:TRIM47
uniprot id: F7HF49
names: Subcellular Location Annotation
messages: Nucleus

9544:CGB8
gene id: 9544:CGB8
uniprot id: Q9GL37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9544:UBR1
gene id: 9544:UBR1
uniprot id: A0A8J8XQB9
uniprot id: G7MWZ8
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9544:YIPF5
gene id: 9544:YIPF5
uniprot id: F7HEG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9544:FKRP
gene id: 9544:FKRP
uniprot id: F6Z946
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9544:SDHAF4
gene id: 9544:SDHAF4
uniprot id: A0A8J8YA11
uniprot id: F7F317
names: Similarity
messages: Belongs to the SDHAF4 family.

9544:PDE1C
gene id: 9544:PDE1C
uniprot id: F7GTC5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:NUCB2
gene id: 9544:NUCB2
uniprot id: A0A5F8A9A8
uniprot id: H9EMB8
names: Similarity
messages: Belongs to the nucleobindin family.

9544:PSMG1
gene id: 9544:PSMG1
uniprot id: A0A8J8XIG5
uniprot id: G7MMS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9544:AREG
gene id: 9544:AREG
uniprot id: A0A8J8YS56
uniprot id: F7D8W9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:STMN2
gene id: 9544:STMN2
uniprot id: F6YBA2
names: Similarity
messages: Belongs to the stathmin family.

9544:TXNL4B
gene id: 9544:TXNL4B
uniprot id: A0A8J8YJ01
uniprot id: F6Z0Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9544:ATP5PD
gene id: 9544:ATP5PD
uniprot id: F6PTU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9544:CHRNA6
gene id: 9544:CHRNA6
uniprot id: A0A1D5QJI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:SYNGR1
gene id: 9544:SYNGR1
uniprot id: F6R375
uniprot id: I0FMX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9544:ALDH3B1
gene id: 9544:ALDH3B1
uniprot id: A0A1D5QTX0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:ARMC9
gene id: 9544:ARMC9
uniprot id: G7N951
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.
messages: centriole
messages: cilium
messages: cilium basal body

9544:MAP3K11
gene id: 9544:MAP3K11
uniprot id: A0A8J8XVV9
uniprot id: F6T3F7
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9544:TUBA1A
gene id: 9544:TUBA1A
uniprot id: F7H3X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9544:MRPL30
gene id: 9544:MRPL30
uniprot id: I2CTH6
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9544:PSMD7
gene id: 9544:PSMD7
uniprot id: F6TS39
names: Similarity
messages: Belongs to the peptidase M67A family.

9544:H2AFY
gene id: 9544:H2AFY
uniprot id: A0A5K1VFC3
uniprot id: A0A8J8XTA7
uniprot id: I0FJN0
uniprot id: I2CUE9
uniprot id: I2CUF0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9544:IL22
gene id: 9544:IL22
uniprot id: A0A8J8XMT2
uniprot id: F6YBU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

9544:NDUFB7
gene id: 9544:NDUFB7
uniprot id: A0A8J8YL08
uniprot id: F7E420
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9544:NDRG4
gene id: 9544:NDRG4
uniprot id: A0A1D5QAP4
uniprot id: A0A1D5RFU9
uniprot id: A0A5F8ALB0
uniprot id: F7GNI4
uniprot id: F7GNI6
uniprot id: H9ETE0
names: Similarity
messages: Belongs to the NDRG family.

9544:MRPS15
gene id: 9544:MRPS15
uniprot id: F6TU46
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9544:METTL15
gene id: 9544:METTL15
uniprot id: F7GN13
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9544:TMEM41A
gene id: 9544:TMEM41A
uniprot id: A0A5F7ZNH4
uniprot id: A0A8J8XYX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9544:PRPSAP2
gene id: 9544:PRPSAP2
uniprot id: A0A1D5Q5E7
uniprot id: G8F168
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9544:MRPS14
gene id: 9544:MRPS14
uniprot id: A0A8J8Y9Q3
uniprot id: F7GV86
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9544:GRIK1
gene id: 9544:GRIK1
uniprot id: F7AGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:RYR2
gene id: 9544:RYR2
uniprot id: F6QN38
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9544:HNF4A
gene id: 9544:HNF4A
uniprot id: F7HBP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:PLP2
gene id: 9544:PLP2
uniprot id: A0A8J8XRA5
uniprot id: G7NR93
names: Subcellular Location Annotation
messages: Membrane

9544:MTMR2
gene id: 9544:MTMR2
uniprot id: A0A8J8Y7A1
uniprot id: I0FK61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9544:DARS2
gene id: 9544:DARS2
uniprot id: A0A5K1V7D4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9544:ZDHHC6
gene id: 9544:ZDHHC6
uniprot id: G7N153
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:SNRNP200
gene id: 9544:SNRNP200
uniprot id: I0FQ43
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9544:LOC719896
gene id: 9544:LOC719896
uniprot id: A0A5F7ZHL0
names: Subcellular Location Annotation
messages: Membrane

9544:HMCES
gene id: 9544:HMCES
uniprot id: A0A1D5RJG4
uniprot id: A0A5F7ZE81
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9544:SLC39A11
gene id: 9544:SLC39A11
uniprot id: H9FR09
names: Subcellular Location Annotation
messages: Membrane

9544:CXHXorf56
gene id: 9544:CXHXorf56
uniprot id: A0A8J8YQ40
uniprot id: G7NT89
names: Similarity
messages: Belongs to the STEEP1 family.

9544:SLC4A4
gene id: 9544:SLC4A4
uniprot id: A0A8J8XE16
uniprot id: F7FRN6
uniprot id: G7MT45
uniprot id: H9G181
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9544:B3GNT8
gene id: 9544:B3GNT8
uniprot id: A0A8J8XSP6
uniprot id: F6Z1M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:SLC7A4
gene id: 9544:SLC7A4
uniprot id: A0A8J8YB83
uniprot id: F6V927
names: Subcellular Location Annotation
messages: Membrane

9544:FTMT
gene id: 9544:FTMT
uniprot id: F7DMG0
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9544:AKAP5
gene id: 9544:AKAP5
uniprot id: A0A1D5QW76
names: Subcellular Location Annotation
messages: Membrane

9544:DYNC2LI1
gene id: 9544:DYNC2LI1
uniprot id: F7H0Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9544:PARD6B
gene id: 9544:PARD6B
uniprot id: I0FVR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9544:SPOP
gene id: 9544:SPOP
uniprot id: A0A8J8XVE9
uniprot id: F6XVE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9544:COQ4
gene id: 9544:COQ4
uniprot id: H9Z9L5
uniprot id: I0FS97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9544:MED30
gene id: 9544:MED30
uniprot id: A0A1D5R5X4
uniprot id: A0A8J8XZX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9544:ABHD3
gene id: 9544:ABHD3
uniprot id: F7B2I5
uniprot id: H9EUP8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9544:GRIN1
gene id: 9544:GRIN1
uniprot id: A0A5K1UHG2
uniprot id: F7G3Q5
uniprot id: F7G6M2
uniprot id: F7GR67
uniprot id: H9EPG1
uniprot id: H9FTE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:RIBC2
gene id: 9544:RIBC2
uniprot id: A0A5F7ZUJ8
names: Similarity
messages: Belongs to the RIB43A family.

9544:NAPB
gene id: 9544:NAPB
uniprot id: A0A1D5QDG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9544:LAMTOR4
gene id: 9544:LAMTOR4
uniprot id: H9FUA4
names: Similarity
messages: Belongs to the LAMTOR4 family.

9544:TLL1
gene id: 9544:TLL1
uniprot id: A0A1D5QYV0
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:AP2A2
gene id: 9544:AP2A2
uniprot id: I2CUB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9544:GABRB1
gene id: 9544:GABRB1
uniprot id: A0A8J8YAF6
uniprot id: G7MSU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:ADAM9
gene id: 9544:ADAM9
uniprot id: F6SGK2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:WLS
gene id: 9544:WLS
uniprot id: H9G004
uniprot id: H9G005
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9544:TBR1
gene id: 9544:TBR1
uniprot id: F7HMW5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:AP5M1
gene id: 9544:AP5M1
uniprot id: F7HK39
uniprot id: F7HM76
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9544:AADACL2
gene id: 9544:AADACL2
uniprot id: A0A8J8XMD3
uniprot id: F6ZWT8
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9544:NDNF
gene id: 9544:NDNF
uniprot id: G7MRW2
names: Subcellular Location Annotation
messages: Secreted

9544:ETFDH
gene id: 9544:ETFDH
uniprot id: H9ESN1
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9544:SPOCK3
gene id: 9544:SPOCK3
uniprot id: A0A5K1U5H8
uniprot id: F7FCP3
uniprot id: H9FV41
uniprot id: I2CYA8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:BDKRB2
gene id: 9544:BDKRB2
uniprot id: A0A1D5QT55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9544:ADAMTS9
gene id: 9544:ADAMTS9
uniprot id: F7H0I0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:ADAM11
gene id: 9544:ADAM11
uniprot id: F7G5P9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:RNFT2
gene id: 9544:RNFT2
uniprot id: A0A8J8XB73
uniprot id: F7D470
names: Subcellular Location Annotation
messages: Membrane

9544:SOGA3
gene id: 9544:SOGA3
uniprot id: F7BRJ0
names: Similarity
messages: Belongs to the SOGA family.

9544:SPATA6
gene id: 9544:SPATA6
uniprot id: F7H5Z0
names: Similarity
messages: Belongs to the SPATA6 family.

9544:ICAM2
gene id: 9544:ICAM2
uniprot id: A0A8J8Y0H8
uniprot id: F7FYU5
uniprot id: Q5NKU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9544:RFC4
gene id: 9544:RFC4
uniprot id: A0A8J8XAS0
uniprot id: F6S9R5
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9544:LYN
gene id: 9544:LYN
uniprot id: A0A8J8YHP5
uniprot id: F7BV42
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9544:FAM83G
gene id: 9544:FAM83G
uniprot id: A0A1D5Q8U1
uniprot id: G8F169
names: Similarity
messages: Belongs to the FAM83 family.

9544:UTP25
gene id: 9544:UTP25
uniprot id: F7HP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9544:XCL1
gene id: 9544:XCL1
uniprot id: Q8HXZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9544:IST1
gene id: 9544:IST1
uniprot id: A0A8J8XAH8
uniprot id: F6YAS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9544:NUP93
gene id: 9544:NUP93
uniprot id: A0A8J8YKY1
uniprot id: G7NPT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9544:LGI2
gene id: 9544:LGI2
uniprot id: A0A5F8ANT9
names: Subcellular Location Annotation
messages: Secreted

9544:UTP14A
gene id: 9544:UTP14A
uniprot id: A0A1D5QIB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9544:OXR1
gene id: 9544:OXR1
uniprot id: A0A5F7ZXG1
uniprot id: A0A5F8AB36
uniprot id: F7DKR5
names: Similarity
messages: Belongs to the OXR1 family.

9544:LSM7
gene id: 9544:LSM7
uniprot id: H9ZA07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9544:MOCS2
gene id: 9544:MOCS2
uniprot id: H9Z947
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9544:KCTD20
gene id: 9544:KCTD20
uniprot id: A0A8J8XEF2
uniprot id: F7GEH1
names: Subcellular Location Annotation
messages: Cytoplasm

9544:ODF2L
gene id: 9544:ODF2L
uniprot id: F7D0W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9544:ZER1
gene id: 9544:ZER1
uniprot id: A0A8J8YMV6
uniprot id: G7NFR5
uniprot id: H9FNQ4
names: Similarity
messages: Belongs to the zyg-11 family.

9544:BMPR1A
gene id: 9544:BMPR1A
uniprot id: F7H4T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9544:AKR1C1
gene id: 9544:AKR1C1
uniprot id: H9FQN9
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9544:NFKB1
gene id: 9544:NFKB1
uniprot id: A0A8J8Y2C4
uniprot id: F6S0D1
uniprot id: F7HKH9
uniprot id: I2CVP9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:CNIH1
gene id: 9544:CNIH1
uniprot id: A0A1D5QEI7
uniprot id: F7FI89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9544:WNT5A
gene id: 9544:WNT5A
uniprot id: A0A5F7ZG37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:NUF2
gene id: 9544:NUF2
uniprot id: F6RPT5
names: Similarity
messages: Belongs to the NUF2 family.

9544:MYCBP
gene id: 9544:MYCBP
uniprot id: F7GS32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

9544:GGACT
gene id: 9544:GGACT
uniprot id: A0A8J8Y490
uniprot id: F7GFS1
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9544:GCNT7
gene id: 9544:GCNT7
uniprot id: F7GNQ8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9544:PDE10A
gene id: 9544:PDE10A
uniprot id: A0A1D5Q6B3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:TP53BP2
gene id: 9544:TP53BP2
uniprot id: F6TIP7
names: Subcellular Location Annotation
messages: Nucleus

9544:CNPY1
gene id: 9544:CNPY1
uniprot id: G7MNJ5
names: Similarity
messages: Belongs to the canopy family.

9544:DAO
gene id: 9544:DAO
uniprot id: G7N5E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9544:TLCD1
gene id: 9544:TLCD1
uniprot id: A0A8J8YQ19
uniprot id: F6S372
names: Subcellular Location Annotation
messages: Membrane

9544:ANAPC15
gene id: 9544:ANAPC15
uniprot id: A0A8J8Y1N1
uniprot id: H9FSL4
names: Similarity
messages: Belongs to the APC15 family.

9544:GDF1
gene id: 9544:GDF1
uniprot id: F6ZBU9
names: Similarity
messages: Belongs to the TGF-beta family.

9544:HOXA7
gene id: 9544:HOXA7
uniprot id: F6YGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:F13A1
gene id: 9544:F13A1
uniprot id: A0A5F8A8L3
uniprot id: A0A8J8YS21
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9544:CYP4F8
gene id: 9544:CYP4F8
uniprot id: F7GXR5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:MNS1
gene id: 9544:MNS1
uniprot id: F7D3Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: Nucleus
messages: cilium axoneme
messages: flagellum axoneme

9544:XRCC6
gene id: 9544:XRCC6
uniprot id: H9ET71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

9544:PYCARD
gene id: 9544:PYCARD
uniprot id: F7EZX3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

9544:SIN3B
gene id: 9544:SIN3B
uniprot id: F6YZ56
uniprot id: F7A9F4
names: Subcellular Location Annotation
messages: Nucleus

9544:GMPPB
gene id: 9544:GMPPB
uniprot id: F7GRF0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9544:EXOC3L1
gene id: 9544:EXOC3L1
uniprot id: F6UJY2
names: Similarity
messages: Belongs to the SEC6 family.

9544:LETMD1
gene id: 9544:LETMD1
uniprot id: F7FK68
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

9544:SMC3
gene id: 9544:SMC3
uniprot id: A0A8J8YBH8
uniprot id: G7N144
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

9544:CASP2
gene id: 9544:CASP2
uniprot id: A0A5F8ANV1
uniprot id: A0A8J8Y729
uniprot id: G7MN58
names: Similarity
messages: Belongs to the peptidase C14A family.

9544:FAM241A
gene id: 9544:FAM241A
uniprot id: A0A5F8AKK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9544:TBX20
gene id: 9544:TBX20
uniprot id: A0A8J8YK47
uniprot id: F7E831
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:EPC1
gene id: 9544:EPC1
uniprot id: A0A1D5QR41
uniprot id: A0A5K1UQ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9544:CDK7
gene id: 9544:CDK7
uniprot id: F6XZK0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9544:LECT2
gene id: 9544:LECT2
uniprot id: A0A8J8XW89
uniprot id: F6VHJ2
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9544:MYO5B
gene id: 9544:MYO5B
uniprot id: A0A1D5QVM8
uniprot id: A0A1D5R6P3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:NEUROD1
gene id: 9544:NEUROD1
uniprot id: A0A8J8XJ39
uniprot id: F7H950
names: Subcellular Location Annotation
messages: Nucleus

9544:SERPINC1
gene id: 9544:SERPINC1
uniprot id: A0N066
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9544:IPO8
gene id: 9544:IPO8
uniprot id: A0A1D5Q2J2
uniprot id: A0A8J8YGE8
names: Subcellular Location Annotation
messages: Cytoplasm

9544:TOMM40
gene id: 9544:TOMM40
uniprot id: F7BSK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9544:NDUFA5
gene id: 9544:NDUFA5
uniprot id: I0FJB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:USB1
gene id: 9544:USB1
uniprot id: A0A8J8YAF4
uniprot id: G7NPV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9544:LAGE3
gene id: 9544:LAGE3
uniprot id: H9FN74
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9544:LOC712810
gene id: 9544:LOC712810
uniprot id: A0A8J8YIR1
uniprot id: F7ELJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9544:SNRPB
gene id: 9544:SNRPB
uniprot id: A0A1D5Q2L1
uniprot id: F6TEZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9544:IL17C
gene id: 9544:IL17C
uniprot id: F7D4L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9544:HBEGF
gene id: 9544:HBEGF
uniprot id: F7FK53
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:MGAT2
gene id: 9544:MGAT2
uniprot id: A0A8J8XXU9
uniprot id: G7MXP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

9544:DPPA2
gene id: 9544:DPPA2
uniprot id: F7H7W1
names: Subcellular Location Annotation
messages: Nucleus

9544:KCNK1
gene id: 9544:KCNK1
uniprot id: F6X4F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9544:DNA2
gene id: 9544:DNA2
uniprot id: F7CAD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Mitochondrion
messages: Nucleus

9544:RABGGTB
gene id: 9544:RABGGTB
uniprot id: F7H489
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9544:CMBL
gene id: 9544:CMBL
uniprot id: A0A8J8XLP7
uniprot id: F7GKB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9544:KIF24
gene id: 9544:KIF24
uniprot id: F7HEG1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:NIM1K
gene id: 9544:NIM1K
uniprot id: F7D9P3
uniprot id: G8F1C4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:HS3ST1
gene id: 9544:HS3ST1
uniprot id: A0A8J8XSS7
uniprot id: F7DQN3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9544:DYRK3
gene id: 9544:DYRK3
uniprot id: F7FZF8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9544:STAT4
gene id: 9544:STAT4
uniprot id: H9YWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9544:TGFB1
gene id: 9544:TGFB1
uniprot id: F7HCV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

9544:LTK
gene id: 9544:LTK
uniprot id: F7HBY2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

9544:POT1
gene id: 9544:POT1
uniprot id: F7C0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9544:SLC25A24
gene id: 9544:SLC25A24
uniprot id: F7H259
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:RGR
gene id: 9544:RGR
uniprot id: F7A8D8
names: Subcellular Location Annotation
messages: Membrane

9544:HENMT1
gene id: 9544:HENMT1
uniprot id: F7H0K7
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9544:RAB3GAP1
gene id: 9544:RAB3GAP1
uniprot id: H9FRI4
uniprot id: H9FRI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm
messages: Endoplasmic reticulum

9544:RAP2C
gene id: 9544:RAP2C
uniprot id: A0A8J8YC58
uniprot id: F6VPD5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9544:SUCLA2
gene id: 9544:SUCLA2
uniprot id: H9EWH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9544:CAD
gene id: 9544:CAD
uniprot id: A0A8J8YIH3
uniprot id: F6PVP0
uniprot id: G7N9N2
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

9544:SAXO1
gene id: 9544:SAXO1
uniprot id: F7GZG2
names: Similarity
messages: Belongs to the FAM154 family.

9544:TMOD3
gene id: 9544:TMOD3
uniprot id: A0A8J8Y580
uniprot id: F7C5M5
names: Subcellular Location Annotation
messages: cytoskeleton

9544:RNF20
gene id: 9544:RNF20
uniprot id: F6VU61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9544:TMA7
gene id: 9544:TMA7
uniprot id: A0A8J8XGR6
uniprot id: F7H2I7
names: Similarity
messages: Belongs to the TMA7 family.

9544:GADL1
gene id: 9544:GADL1
uniprot id: F6Q185
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9544:ATL2
gene id: 9544:ATL2
uniprot id: F6TI01
uniprot id: F6YCC3
uniprot id: H9FYE2
uniprot id: H9YZA6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9544:P2RX3
gene id: 9544:P2RX3
uniprot id: A0A1D5QSM7
uniprot id: A0A8J8XQL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9544:TMEM38B
gene id: 9544:TMEM38B
uniprot id: A0A8J8XPP4
uniprot id: F7H2N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9544:SNRPD1
gene id: 9544:SNRPD1
uniprot id: H9ZCP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9544:STAG1
gene id: 9544:STAG1
uniprot id: H9EMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9544:P4HA1
gene id: 9544:P4HA1
uniprot id: A0A8J8Y6S5
uniprot id: G7N269
uniprot id: H9Z9F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9544:DEFA4
gene id: 9544:DEFA4
uniprot id: Q5I2P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9544:USP1
gene id: 9544:USP1
uniprot id: A0A8J8Y508
uniprot id: G7MHB3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:SV2B
gene id: 9544:SV2B
uniprot id: A0A8J8YP16
uniprot id: H9EMI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9544:CSNK2B
gene id: 9544:CSNK2B
uniprot id: G7MRJ2
uniprot id: H9ENN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9544:CASP14
gene id: 9544:CASP14
uniprot id: F7GZH3
names: Similarity
messages: Belongs to the peptidase C14A family.

9544:MFSD5
gene id: 9544:MFSD5
uniprot id: A0A5F7ZTM2
uniprot id: A0A8J8XET1
uniprot id: F6RB32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

9544:HCFC2
gene id: 9544:HCFC2
uniprot id: F6ZF51
names: Subcellular Location Annotation
messages: Nucleus

9544:SGCG
gene id: 9544:SGCG
uniprot id: A0A5K1TU54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9544:AP3B2
gene id: 9544:AP3B2
uniprot id: F6Y1H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9544:ZNF280C
gene id: 9544:ZNF280C
uniprot id: A0A5F7ZWA2
uniprot id: F6T648
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9544:PAM
gene id: 9544:PAM
uniprot id: I0FS58
uniprot id: I2CX43
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 2 Cu(2+) ions per subunit.
messages: Binds one Zn(2+) ion per subunit.
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9544:WNT11
gene id: 9544:WNT11
uniprot id: F7EV26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:HINT2
gene id: 9544:HINT2
uniprot id: A0A8J8Y281
uniprot id: F7GRL0
names: Similarity
messages: Belongs to the HINT family.

9544:TMEM258
gene id: 9544:TMEM258
uniprot id: F7H3Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9544:GPR20
gene id: 9544:GPR20
uniprot id: F6PT20
uniprot id: G8F1I2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:BCAP31
gene id: 9544:BCAP31
uniprot id: A0A5F7ZNT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9544:CLASP1
gene id: 9544:CLASP1
uniprot id: F6QKC2
uniprot id: H9FRZ4
uniprot id: I0FQA8
uniprot id: I0FQA9
names: Subcellular Location Annotation
messages: kinetochore

9544:PAX8
gene id: 9544:PAX8
uniprot id: F6PPM6
names: Subcellular Location Annotation
messages: Nucleus

9544:PNLDC1
gene id: 9544:PNLDC1
uniprot id: F6X2Q9
names: Similarity
messages: Belongs to the CAF1 family.

9544:OXER1
gene id: 9544:OXER1
uniprot id: A0A8J8XLH6
uniprot id: F6X8C7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:LSM4
gene id: 9544:LSM4
uniprot id: F7GUB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9544:RPL36AL
gene id: 9544:RPL36AL
uniprot id: A0A8J8Y079
uniprot id: F6VSQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9544:CIT
gene id: 9544:CIT
uniprot id: A0A5K1U3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

9544:RPL10
gene id: 9544:RPL10
uniprot id: F7GKJ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9544:SFTPA1
gene id: 9544:SFTPA1
uniprot id: Q9TUC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFTPA family.
messages: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
messages: Oligomeric complex of 6 set of homotrimers.
messages: Secreted
messages: extracellular matrix
messages: surface film

9544:IRAK2
gene id: 9544:IRAK2
uniprot id: G7MKR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9544:GSX2
gene id: 9544:GSX2
uniprot id: A0A1D5R9U9
names: Subcellular Location Annotation
messages: Nucleus

9544:LOC699679
gene id: 9544:LOC699679
uniprot id: A0A5F8AGP2
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9544:CNIH3
gene id: 9544:CNIH3
uniprot id: F6RG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9544:HSCB
gene id: 9544:HSCB
uniprot id: F6VJ72
names: Similarity
messages: Belongs to the HscB family.

9544:NOP53
gene id: 9544:NOP53
uniprot id: H9EWQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

9544:KNG1
gene id: 9544:KNG1
uniprot id: G7MK69
names: Subcellular Location Annotation
messages: extracellular space

9544:PODXL
gene id: 9544:PODXL
uniprot id: A0A5F7ZB91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the podocalyxin family.
messages: Cell membrane
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
messages: Membrane
messages: Membrane raft
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

9544:ZKSCAN8
gene id: 9544:ZKSCAN8
uniprot id: A0A8J8XDW6
uniprot id: F7EH74
names: Subcellular Location Annotation
messages: Nucleus

9544:RTD1C
gene id: 9544:RTD1C
uniprot id: Q9GLR2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the alpha-defensin family. Theta subfamily.
messages: Forms a cyclic homodimer; disulfide-linked.
messages: Has antimicrobial activities against bacteria and fungi.
messages: The mature 9-residue peptide is expected to be found in 18-residue cyclopeptides produced by combinatorial peptide splicing either with itself or with other demidefensins. However among cyclopeptides screened for antimicrobial activity, no peptides that would have been produced from this sequence were detected.
messages: This is a cyclic peptide.

9544:TOR1B
gene id: 9544:TOR1B
uniprot id: H9ESY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9544:RALY
gene id: 9544:RALY
uniprot id: A0A5F8APZ8
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9544:B3GNT4
gene id: 9544:B3GNT4
uniprot id: F7E7L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:TMEM106A
gene id: 9544:TMEM106A
uniprot id: A0A8J8XEQ5
uniprot id: F7CWZ4
uniprot id: G7NIU8
names: Similarity
messages: Belongs to the TMEM106 family.

9544:ZSCAN30
gene id: 9544:ZSCAN30
uniprot id: A0A5F7Z7C0
names: Subcellular Location Annotation
messages: Nucleus

9544:GPR4
gene id: 9544:GPR4
uniprot id: F6R9Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CDC37
gene id: 9544:CDC37
uniprot id: A0A1D5RA77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9544:RUNX1T1
gene id: 9544:RUNX1T1
uniprot id: A0A1D5QY91
uniprot id: A0A1D5RH10
uniprot id: A0A8J8XVW4
uniprot id: F6Q6G9
uniprot id: F7DLI2
names: Similarity
messages: Belongs to the CBFA2T family.

9544:GSTT1
gene id: 9544:GSTT1
uniprot id: A0A023JCR6
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9544:SS18
gene id: 9544:SS18
uniprot id: A0A1D5R9F8
uniprot id: F7EQE4
names: Similarity
messages: Belongs to the SS18 family.

9544:MYSM1
gene id: 9544:MYSM1
uniprot id: F7A6Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.
messages: Nucleus

9544:RPL29
gene id: 9544:RPL29
uniprot id: A0A8J8YHL0
uniprot id: F6QGB0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9544:L1CAM
gene id: 9544:L1CAM
uniprot id: A0A5K1UIJ6
uniprot id: F7FEV5
uniprot id: I0FK44
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9544:SDC2
gene id: 9544:SDC2
uniprot id: A0A8J8YSZ3
uniprot id: F6QQP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9544:DIPK2A
gene id: 9544:DIPK2A
uniprot id: A0A8J8Y358
uniprot id: F7HNR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9544:NCEH1
gene id: 9544:NCEH1
uniprot id: F6PMM4
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9544:TRIM17
gene id: 9544:TRIM17
uniprot id: F7GJW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9544:PDCL2
gene id: 9544:PDCL2
uniprot id: F7H2W1
names: Similarity
messages: Belongs to the phosducin family.

9544:CAP1
gene id: 9544:CAP1
uniprot id: F7FR05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9544:OR1F1
gene id: 9544:OR1F1
uniprot id: A0A5F7ZWF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:VPS52
gene id: 9544:VPS52
uniprot id: A0A5F8A6D4
uniprot id: A0A8J8Y601
names: Similarity
messages: Belongs to the VPS52 family.

9544:CFTR
gene id: 9544:CFTR
uniprot id: Q00553
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).
messages: N-glycosylated.
messages: Nucleus
messages: Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.
messages: Recycling endosome membrane
messages: The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, NHERF1/EBP50 complex.
messages: The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.
messages: Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity).

9544:SCPEP1
gene id: 9544:SCPEP1
uniprot id: A0A8J8XU42
uniprot id: H9ZBZ0
names: Similarity
messages: Belongs to the peptidase S10 family.

9544:LOC709712
gene id: 9544:LOC709712
uniprot id: A0A1D5R1T6
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:ACTBL2
gene id: 9544:ACTBL2
uniprot id: A0A5F7ZDE6
names: Similarity
messages: Belongs to the actin family.

9544:MSX1
gene id: 9544:MSX1
uniprot id: Q2VL87
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor (By similarity). Capable of transcription autoinactivation (By similarity). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (By similarity). Represses transcription of myoblast differentiation factors (By similarity). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (By similarity). Recruits histone H3 methyltransferases such as EHMT2/G9a to gene promoter regions which leads to inhibition of myoblast differentiation via transcriptional repression of differentiation factors (By similarity). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (By similarity). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (By similarity). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (By similarity). Required for BMP4 expression in dental mesenchyme cells (By similarity). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (By similarity). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (By similarity). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (By similarity). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle (By similarity). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB…
messages: Belongs to the Msh homeobox family.
messages: Interacts with CREBBP/CBP, TBP and SP1; interaction with these transcription activators may inhibit autoinactivation (By similarity). Interacts (via homeobox domain) with EHMT2/G9a (By similarity). Interacts with EHMT1/GLP (By similarity). Interacts (via C-terminus) with PIAS1 (via N-terminus); the interaction is required for the localization of both proteins to the nuclear periphery and specific binding of MSX1 to the core enhancer region in target gene promoters (By similarity). Interacts with H1-5 (By similarity).
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Nucleus
messages: Sumoylated by PIAS1, desumoylated by SENP1 (By similarity). Sumoylation of Lys-15 and Lys-133 not required for interaction with H1-5, transcriptional repression, inhibition of myoblast differentiation, or binding to gene promoters (By similarity).

9544:TFDP2
gene id: 9544:TFDP2
uniprot id: A0A1D5QK34
uniprot id: F6TKB7
uniprot id: F6TQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9544:GLB1L
gene id: 9544:GLB1L
uniprot id: G7N8Z4
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9544:DCTD
gene id: 9544:DCTD
uniprot id: A0A5F8AEQ9
uniprot id: H9FQN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm

9544:TBC1D24
gene id: 9544:TBC1D24
uniprot id: F6TFP7
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse

9544:SPESP1
gene id: 9544:SPESP1
uniprot id: F6TNB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPESP1 family.
messages: Involved in fertilization ability of sperm.
messages: acrosome

9544:TCEANC2
gene id: 9544:TCEANC2
uniprot id: F6YTA6
names: Subcellular Location Annotation
messages: Nucleus

9544:BNIP1
gene id: 9544:BNIP1
uniprot id: A0A8J8XK36
uniprot id: F7GPV1
names: Subcellular Location Annotation
messages: Membrane

9544:SPATS2L
gene id: 9544:SPATS2L
uniprot id: A0A1D5Q2L8
uniprot id: A0A5F7ZD85
uniprot id: F7HIW4
names: Similarity
messages: Belongs to the SPATS2 family.

9544:CDS2
gene id: 9544:CDS2
uniprot id: A0A8J8XN71
uniprot id: G7N2W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9544:DNASE2B
gene id: 9544:DNASE2B
uniprot id: F6X4X0
uniprot id: G8F191
names: Similarity
messages: Belongs to the DNase II family.

9544:CTSW
gene id: 9544:CTSW
uniprot id: A0A8J8YHW3
uniprot id: F7F868
names: Similarity
messages: Belongs to the peptidase C1 family.

9544:NTNG2
gene id: 9544:NTNG2
uniprot id: H9G0U9
uniprot id: I2CYB5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NPR2
gene id: 9544:NPR2
uniprot id: F2YI45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9544:LPIN2
gene id: 9544:LPIN2
uniprot id: H9G2A5
names: Similarity
messages: Belongs to the lipin family.

9544:TMEM159
gene id: 9544:TMEM159
uniprot id: A0A1D5QJT0
uniprot id: A0A8J8XFC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9544:FBXO48
gene id: 9544:FBXO48
uniprot id: A0A8J8Y6E4
uniprot id: F6T7T4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9544:ZNF532
gene id: 9544:ZNF532
uniprot id: F7D3P1
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9544:NDUFV1
gene id: 9544:NDUFV1
uniprot id: G7NBW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9544:SAR1B
gene id: 9544:SAR1B
uniprot id: A0A8J8Y951
uniprot id: H9EUG4
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9544:SUCNR1
gene id: 9544:SUCNR1
uniprot id: A0A5F7ZNC1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:KRI1
gene id: 9544:KRI1
uniprot id: F6X3H2
names: Similarity
messages: Belongs to the KRI1 family.

9544:NFIX
gene id: 9544:NFIX
uniprot id: A0A1D5QZS6
uniprot id: F6SA24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9544:SERPINF2
gene id: 9544:SERPINF2
uniprot id: G7NHS7
names: Similarity
messages: Belongs to the serpin family.

9544:DEFB121
gene id: 9544:DEFB121
uniprot id: G7N560
uniprot id: Q5J600
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant expression in the male reproductive tract only.
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:PEMT
gene id: 9544:PEMT
uniprot id: F7H990
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9544:DEF8
gene id: 9544:DEF8
uniprot id: F6X5P1
names: Similarity
messages: Belongs to the DEF8 family.

9544:FUT8
gene id: 9544:FUT8
uniprot id: A0A8J8XWH6
uniprot id: F7BVV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9544:TBXAS1
gene id: 9544:TBXAS1
uniprot id: A0A5F7ZQR3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:FAM207A
gene id: 9544:FAM207A
uniprot id: F7EKK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

9544:CCL2
gene id: 9544:CCL2
uniprot id: A0A8J8YA47
uniprot id: P61275
uniprot id: Q71ME7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Monomer or homodimer; in equilibrium. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Interacts with TNFAIP6 (via Link domain).
messages: N-Glycosylated.
messages: Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).
messages: Secreted

9544:PLP1
gene id: 9544:PLP1
uniprot id: I0FH09
uniprot id: I0FH10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9544:XPNPEP2
gene id: 9544:XPNPEP2
uniprot id: A0A1D5RFF9
names: Similarity
messages: Belongs to the peptidase M24B family.

9544:MSMB
gene id: 9544:MSMB
uniprot id: P25142
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-microseminoprotein family.
messages: Homodimer; Interacts with PI16.
messages: Secreted

9544:FPR1
gene id: 9544:FPR1
uniprot id: A0A8J8YFZ5
uniprot id: F7H7V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9544:FGB
gene id: 9544:FGB
uniprot id: F6UZ87
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9544:KAT7
gene id: 9544:KAT7
uniprot id: A0A1D5QUW5
uniprot id: H9ENC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9544:DBR1
gene id: 9544:DBR1
uniprot id: H9Z9M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

9544:RPL36
gene id: 9544:RPL36
uniprot id: A0A1D5Q793
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9544:TMEM184B
gene id: 9544:TMEM184B
uniprot id: A0A1D5QY94
uniprot id: A0A8J8XIJ3
uniprot id: G7N3U8
names: Subcellular Location Annotation
messages: Membrane

9544:RFX1
gene id: 9544:RFX1
uniprot id: A0A5F7Z844
uniprot id: F6Y5S3
names: Subcellular Location Annotation
messages: Nucleus

9544:PELI3
gene id: 9544:PELI3
uniprot id: F7FEZ0
uniprot id: F7FIJ8
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9544:FAM53B
gene id: 9544:FAM53B
uniprot id: H9G2B5
names: Similarity
messages: Belongs to the FAM53 family.

9544:FNBP1L
gene id: 9544:FNBP1L
uniprot id: H9EMF5
uniprot id: H9EMF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9544:CEP70
gene id: 9544:CEP70
uniprot id: F7BWK0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

9544:E2F1
gene id: 9544:E2F1
uniprot id: F7DEJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9544:LOC716633
gene id: 9544:LOC716633
uniprot id: F7CZ86
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9544:INTS12
gene id: 9544:INTS12
uniprot id: A0A8J8XFG9
uniprot id: G7MTK2
names: Similarity
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

9544:HOXC5
gene id: 9544:HOXC5
uniprot id: A0A8J8YG14
uniprot id: G7N762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:SPECC1L
gene id: 9544:SPECC1L
uniprot id: F6WRA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9544:GSC2
gene id: 9544:GSC2
uniprot id: F7HKV0
names: Subcellular Location Annotation
messages: Nucleus

9544:PPT2
gene id: 9544:PPT2
uniprot id: A0A5F8APR1
uniprot id: F7HF28
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9544:RAB43
gene id: 9544:RAB43
uniprot id: I0FIG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

9544:LOC717247
gene id: 9544:LOC717247
uniprot id: A0A1D5Q2F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9544:NR1D1
gene id: 9544:NR1D1
uniprot id: I2CUB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:ASIC2
gene id: 9544:ASIC2
uniprot id: H9F9G2
names: Subcellular Location Annotation
messages: Membrane

9544:ACTL6A
gene id: 9544:ACTL6A
uniprot id: A0A5F8AAX6
uniprot id: A0A8J8XHI5
uniprot id: H9ENZ8
names: Similarity
messages: Belongs to the actin family.

9544:NAV1
gene id: 9544:NAV1
uniprot id: H9G1G5
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9544:GPR171
gene id: 9544:GPR171
uniprot id: F7HBT2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:CLEC16A
gene id: 9544:CLEC16A
uniprot id: H9Z6X0
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9544:ST8SIA4
gene id: 9544:ST8SIA4
uniprot id: A0A8J8YQ45
uniprot id: G7MVH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:RIMKLA
gene id: 9544:RIMKLA
uniprot id: A0A8J8YR61
uniprot id: G7MGC4
names: Similarity
messages: Belongs to the RimK family.

9544:S100A10
gene id: 9544:S100A10
uniprot id: A0A8J8XSG0
uniprot id: G7MDL9
uniprot id: P62504
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
messages: Belongs to the S-100 family.
messages: Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.
messages: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with SCN10A (By similarity). Interacts with TASOR (By similarity).

9544:RTD1A
gene id: 9544:RTD1A
uniprot id: P82270
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the alpha-defensin family. Theta subfamily.
messages: Forms a cyclic peptide with subunit A (RTD-3) or with subunit B (RTD-1). An additional intersubunit disulfide bond is formed.
messages: RTD-1 and RTD-3 have similar antimicrobial activities against the Gram-positive bacteria S.aureus 502A and L.monocytogenes, the Gram-negative bacteria S.typhimurium and E.coli ML35, and the fungi C.albicans 16820 and C.neoformans 271A.
messages: RTD-1 expression begins early during granulocyte myelopoiesis.
messages: RTD-1 is 10-fold more present in cells than RTD-3.
messages: RTD-1 is a cyclic heterodimer composed of subunits A and B; disulfide-linked (PubMed:23148585). RTD-3 is a cyclic homodimer composed of two subunits A; disulfide-linked.
messages: RTD-1 is expressed in bone marrow. Detected in promyelocytes, myelocytes and mature neutrophils and monocytes.

9544:ATP9B
gene id: 9544:ATP9B
uniprot id: G7NKA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9544:YTHDF2
gene id: 9544:YTHDF2
uniprot id: A0A1D5QRD2
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9544:MIEF2
gene id: 9544:MIEF2
uniprot id: F7H3Q0
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9544:LMLN
gene id: 9544:LMLN
uniprot id: H9H2M5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

9544:TRMT1L
gene id: 9544:TRMT1L
uniprot id: A0A8J8YGE1
uniprot id: F6RCB6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

9544:RBM8A
gene id: 9544:RBM8A
uniprot id: A0A8J8XIR9
uniprot id: H9ZG30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9544:BCL9
gene id: 9544:BCL9
uniprot id: A0A8J8XAC9
uniprot id: F7D4Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9544:CCNK
gene id: 9544:CCNK
uniprot id: F7DAF2
names: Similarity
messages: Belongs to the cyclin family.

9544:SLC37A4
gene id: 9544:SLC37A4
uniprot id: G7NCE1
uniprot id: H9Z2D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9544:UBE2I
gene id: 9544:UBE2I
uniprot id: H9ZD43
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:PPIF
gene id: 9544:PPIF
uniprot id: I0FMN3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9544:DDX39B
gene id: 9544:DDX39B
uniprot id: Q5TM17
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DECD subfamily.
messages: Cytoplasm
messages: Homodimer, and heterodimer with DDX39A. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex bridges ALYREF/THOC4 and the THO complex, and, in a ATP-dependent manner, ALYREF/THOC4 and SARNP/CIP29. Component of the spliceosome. Interacts directly with U2AF2. Interacts with RBM8A, RNPS1 and SRRM1, FYTTD1/UIF, THOC1, MX1 and POLDIP3. Interacts with LUZP4.
messages: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.
messages: Nucleus
messages: Nucleus speckle
messages: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [] reporting a stimulatory effect.
messages: The helicase C-terminal domain mediates interaction with ALYREF/THOC4.

9544:HMMR
gene id: 9544:HMMR
uniprot id: F7CKK0
names: Subcellular Location Annotation
messages: spindle

9544:BRMS1
gene id: 9544:BRMS1
uniprot id: F6XMQ9
names: Subcellular Location Annotation
messages: Nucleus

9544:PPP1CC
gene id: 9544:PPP1CC
uniprot id: F7GFT6
uniprot id: H9YUD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9544:PORCN
gene id: 9544:PORCN
uniprot id: A0A1D5R881
uniprot id: A0A5F7ZRQ0
uniprot id: A0A8J8XBU4
uniprot id: F7A6R5
uniprot id: G7NR69
names: Subcellular Location Annotation
messages: Membrane

9544:GPR180
gene id: 9544:GPR180
uniprot id: A0A8J8XQH1
uniprot id: F7H5N5
names: Subcellular Location Annotation
messages: Membrane

9544:PDE4D
gene id: 9544:PDE4D
uniprot id: F7GZT2
uniprot id: F7GZV2
uniprot id: F7GZV4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:PDIA6
gene id: 9544:PDIA6
uniprot id: A0A1D5RHH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

9544:FAM122B
gene id: 9544:FAM122B
uniprot id: A0A8J8YEM5
uniprot id: G7NRM3
uniprot id: H9FQJ6
uniprot id: H9FQJ7
uniprot id: H9Z5R6
uniprot id: H9Z5R7
uniprot id: H9Z5R8
names: Similarity
messages: Belongs to the FAM122 family.

9544:ARF1
gene id: 9544:ARF1
uniprot id: F7H235
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9544:LOC707644
gene id: 9544:LOC707644
uniprot id: A0A8J8YRA7
uniprot id: F7HKY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9544:SDF4
gene id: 9544:SDF4
uniprot id: H9FVA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

9544:F2RL2
gene id: 9544:F2RL2
uniprot id: F6U5U6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:LSM12
gene id: 9544:LSM12
uniprot id: F7GZM1
names: Similarity
messages: Belongs to the LSM12 family.

9544:ELF3
gene id: 9544:ELF3
uniprot id: F6TYX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:PUS3
gene id: 9544:PUS3
uniprot id: G7NCX7
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9544:ATP6V0A1
gene id: 9544:ATP6V0A1
uniprot id: A0A8J8XCE0
uniprot id: F7FMM0
uniprot id: G7NIL3
uniprot id: H9ZA69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9544:CREG1
gene id: 9544:CREG1
uniprot id: A0A5F7ZC82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9544:CD70
gene id: 9544:CD70
uniprot id: A0A0U5EM75
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9544:CD9
gene id: 9544:CD9
uniprot id: F7GKZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

9544:YWHAG
gene id: 9544:YWHAG
uniprot id: F6XLR8
names: Similarity
messages: Belongs to the 14-3-3 family.

9544:TSPAN4
gene id: 9544:TSPAN4
uniprot id: H9FZ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:SMIM14
gene id: 9544:SMIM14
uniprot id: A0A8J8Y681
uniprot id: G7MSS3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9544:ZDHHC9
gene id: 9544:ZDHHC9
uniprot id: A0A8J8YD68
uniprot id: G7NRE0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:SELE
gene id: 9544:SELE
uniprot id: A0A1D5QPQ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:NDUFAF4
gene id: 9544:NDUFAF4
uniprot id: A0A5F7ZMH3
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9544:MCM3
gene id: 9544:MCM3
uniprot id: A0A1D5Q7N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9544:DCAF11
gene id: 9544:DCAF11
uniprot id: A0A5F7ZXH6
uniprot id: H9YV89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9544:MTNR1B
gene id: 9544:MTNR1B
uniprot id: F7F3W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ZSCAN16
gene id: 9544:ZSCAN16
uniprot id: A0A8J8Y505
uniprot id: F7EHB8
names: Subcellular Location Annotation
messages: Nucleus

9544:YWHAE
gene id: 9544:YWHAE
uniprot id: A0A1D5Q9M4
uniprot id: A0A1D5QIF8
uniprot id: I0FUX3
names: Similarity
messages: Belongs to the 14-3-3 family.

9544:KCNA6
gene id: 9544:KCNA6
uniprot id: A0A5F8AKP8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:IL3
gene id: 9544:IL3
uniprot id: G7MTY2
uniprot id: P25140
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated T-cells, mast cells, natural killer cells.
messages: Belongs to the IL-3 family.
messages: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
messages: Monomer.
messages: Secreted
messages: This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

9544:OSBPL6
gene id: 9544:OSBPL6
uniprot id: A0A1D5R8B0
uniprot id: A0A8J8YL42
uniprot id: F6WMQ6
uniprot id: F6WMR4
uniprot id: F6WN07
uniprot id: G7N8E7
names: Similarity
messages: Belongs to the OSBP family.

9544:MPZ
gene id: 9544:MPZ
uniprot id: A0A5F8A6B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Homodimer and homotetramer.
messages: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
messages: Membrane

9544:TLR8
gene id: 9544:TLR8
uniprot id: B3Y660
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9544:PRKD2
gene id: 9544:PRKD2
uniprot id: F7ES71
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9544:IFNA13
gene id: 9544:IFNA13
uniprot id: A0A5F8AJA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:TRIM2
gene id: 9544:TRIM2
uniprot id: A0A1D5QWE0
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9544:SOAT2
gene id: 9544:SOAT2
uniprot id: F6RU63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:LOC704609
gene id: 9544:LOC704609
uniprot id: A0A5F8AS41
names: Similarity
messages: Belongs to the actin family.

9544:MGA
gene id: 9544:MGA
uniprot id: F6TX76
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:CNOT6L
gene id: 9544:CNOT6L
uniprot id: A0A5F8AFT7
uniprot id: F6UUL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9544:DIMT1
gene id: 9544:DIMT1
uniprot id: A0A5K1VAG0
uniprot id: A0A8J8YSQ6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9544:PRKCA
gene id: 9544:PRKCA
uniprot id: A0A5F8A004
uniprot id: H9EMT3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

9544:GATA3
gene id: 9544:GATA3
uniprot id: A0A8J8YEY1
uniprot id: F7E1F3
names: Subcellular Location Annotation
messages: Nucleus

9544:DEGS1
gene id: 9544:DEGS1
uniprot id: F6PPX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:GPR50
gene id: 9544:GPR50
uniprot id: A0A8J8Y926
uniprot id: F7GTE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:XPO1
gene id: 9544:XPO1
uniprot id: A0A8J8XEW2
uniprot id: F6ZZ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9544:EFNA5
gene id: 9544:EFNA5
uniprot id: A0A8J8Y8X9
uniprot id: F7GZC7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:DPT
gene id: 9544:DPT
uniprot id: A0A8J8XHL3
uniprot id: G7MF99
names: Similarity
messages: Belongs to the dermatopontin family.

9544:SF3B6
gene id: 9544:SF3B6
uniprot id: A0A1D5RF54
uniprot id: A0A8J8XF05
names: Subcellular Location Annotation
messages: Nucleus

9544:CD164
gene id: 9544:CD164
uniprot id: A0A8J8XHG4
uniprot id: F7F631
uniprot id: F7F654
uniprot id: H9G1A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9544:THUMPD3
gene id: 9544:THUMPD3
uniprot id: H9FSL6
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9544:SSTR2
gene id: 9544:SSTR2
uniprot id: A0A8J8YCU0
uniprot id: G7NJD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9544:AMELX
gene id: 9544:AMELX
uniprot id: A5JJS8
names: Similarity
messages: Belongs to the amelogenin family.

9544:LOC106995434
gene id: 9544:LOC106995434
uniprot id: A0A1D5QMI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9544:LOC704480
gene id: 9544:LOC704480
uniprot id: A0A1D5QPN6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9544:LYPLA2
gene id: 9544:LYPLA2
uniprot id: F7CKM3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9544:TLE3
gene id: 9544:TLE3
uniprot id: H9EN36
uniprot id: H9ZCZ0
uniprot id: H9ZCZ1
uniprot id: H9ZCZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9544:ZNF213
gene id: 9544:ZNF213
uniprot id: G7NP67
names: Subcellular Location Annotation
messages: Nucleus

9544:PFKL
gene id: 9544:PFKL
uniprot id: H9FVT0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CLDN4
gene id: 9544:CLDN4
uniprot id: A0A8J8YFZ1
uniprot id: F6YR27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:MPP6
gene id: 9544:MPP6
uniprot id: A0A1D5R1Q9
uniprot id: F7CCP1
names: Similarity
messages: Belongs to the MAGUK family.

9544:FN3KRP
gene id: 9544:FN3KRP
uniprot id: H9ZDK8
names: Similarity
messages: Belongs to the fructosamine kinase family.

9544:TBX5
gene id: 9544:TBX5
uniprot id: A0A8J8XSR3
uniprot id: F7FPV2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:LOC696808
gene id: 9544:LOC696808
uniprot id: A0A1D5RH28
uniprot id: A0A8J8XC48
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:TMED1
gene id: 9544:TMED1
uniprot id: A0A8J8Y0R0
uniprot id: F7GWE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9544:CNRIP1
gene id: 9544:CNRIP1
uniprot id: A0A8J8XIQ4
uniprot id: F7G8D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9544:VDAC2
gene id: 9544:VDAC2
uniprot id: H9FZD7
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9544:KCNK10
gene id: 9544:KCNK10
uniprot id: A0A8J8Y9I5
uniprot id: G7MYY4
uniprot id: H9FW02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9544:PHF5A
gene id: 9544:PHF5A
uniprot id: H9EQL3
names: Similarity
messages: Belongs to the PHF5 family.

9544:HCRT
gene id: 9544:HCRT
uniprot id: F7GWM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Endoplasmic reticulum
messages: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

9544:TEKT2
gene id: 9544:TEKT2
uniprot id: F7GQI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9544:TMSB4X
gene id: 9544:TMSB4X
uniprot id: I0FUP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9544:HPSE2
gene id: 9544:HPSE2
uniprot id: A0A5K1VN08
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9544:FMO2
gene id: 9544:FMO2
uniprot id: F7B614
uniprot id: Q28505
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:HBE1
gene id: 9544:HBE1
uniprot id: G7NE40
uniprot id: Q28507
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.
messages: Red blood cells.
messages: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

9544:ALDH8A1
gene id: 9544:ALDH8A1
uniprot id: F7GPI8
uniprot id: F7GPJ0
uniprot id: G7MQB3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:BARX2
gene id: 9544:BARX2
uniprot id: A0A8J8YMW1
uniprot id: F7BAQ7
names: Subcellular Location Annotation
messages: Nucleus

9544:NDUFS7
gene id: 9544:NDUFS7
uniprot id: I0FRI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 20 kDa subunit family.
messages: Mitochondrion inner membrane

9544:MTMR7
gene id: 9544:MTMR7
uniprot id: A0A8J8YCB2
uniprot id: F7GMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9544:PRPF4
gene id: 9544:PRPF4
uniprot id: F6TT47
names: Subcellular Location Annotation
messages: Nucleus speckle

9544:USP13
gene id: 9544:USP13
uniprot id: F7EMP5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:DYNLRB1
gene id: 9544:DYNLRB1
uniprot id: F7B1L6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9544:TM4SF1
gene id: 9544:TM4SF1
uniprot id: H9EV53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9544:PGS1
gene id: 9544:PGS1
uniprot id: G7NH04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9544:CLDN15
gene id: 9544:CLDN15
uniprot id: A0A8J8YGZ3
uniprot id: F7CD22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:TOM1L2
gene id: 9544:TOM1L2
uniprot id: F7ED62
uniprot id: I0FPF0
names: Similarity
messages: Belongs to the TOM1 family.

9544:GLUD1
gene id: 9544:GLUD1
uniprot id: H9Z7V8
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

9544:CCL28
gene id: 9544:CCL28
uniprot id: Q8HYP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:GNAQ
gene id: 9544:GNAQ
uniprot id: H9FT55
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9544:APLP2
gene id: 9544:APLP2
uniprot id: F7FJ74
uniprot id: H9FTU9
uniprot id: H9FTV0
uniprot id: I0FRD6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:INTS2
gene id: 9544:INTS2
uniprot id: A0A5F7ZF87
names: Similarity
messages: Belongs to the Integrator subunit 2 family.

9544:SLC10A6
gene id: 9544:SLC10A6
uniprot id: F6S0G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9544:CLDN2
gene id: 9544:CLDN2
uniprot id: G7NSX3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:KCNJ10
gene id: 9544:KCNJ10
uniprot id: A0A8J8Y8V6
uniprot id: F6V197
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:PPT1
gene id: 9544:PPT1
uniprot id: I0FT61
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9544:PEAR1
gene id: 9544:PEAR1
uniprot id: A0A5F7ZWC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SF3B1
gene id: 9544:SF3B1
uniprot id: A0A8J8Y5B4
uniprot id: F7BGA8
uniprot id: G7N8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9544:MRPS11
gene id: 9544:MRPS11
uniprot id: F7GG48
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9544:KCNJ8
gene id: 9544:KCNJ8
uniprot id: F7H7S9
uniprot id: Q0GF14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:SEPTIN2
gene id: 9544:SEPTIN2
uniprot id: A0A1D5QRL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9544:GPR37L1
gene id: 9544:GPR37L1
uniprot id: A0A8J8YNU6
uniprot id: F6TEF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:RELL2
gene id: 9544:RELL2
uniprot id: A0A8J8YBH3
uniprot id: F6V688
names: Similarity
messages: Belongs to the RELT family.

9544:NDUFS1
gene id: 9544:NDUFS1
uniprot id: F7CZI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

9544:RHBDL1
gene id: 9544:RHBDL1
uniprot id: A0A8J8Y083
uniprot id: G7NQE4
names: Subcellular Location Annotation
messages: Membrane

9544:AWAT1
gene id: 9544:AWAT1
uniprot id: A0A8J8YID6
uniprot id: F6SLT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9544:SUZ12
gene id: 9544:SUZ12
uniprot id: A0A5F8A8X4
uniprot id: F6PUM4
names: Similarity
messages: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

9544:ATP1A2
gene id: 9544:ATP1A2
uniprot id: A0A1D5R1L9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:DENND6A
gene id: 9544:DENND6A
uniprot id: A0A1D5R1E5
uniprot id: F6XZK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

9544:ACTG2
gene id: 9544:ACTG2
uniprot id: A0A8J8XIV8
uniprot id: F6UA63
names: Similarity
messages: Belongs to the actin family.

9544:EHD4
gene id: 9544:EHD4
uniprot id: F7HAE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9544:C8H8orf37
gene id: 9544:C8H8orf37
uniprot id: H9FQI8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9544:STK38
gene id: 9544:STK38
uniprot id: H9Z4Y8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:MTCH2
gene id: 9544:MTCH2
uniprot id: A0A1D5RG12
uniprot id: H9ETT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:EIF5
gene id: 9544:EIF5
uniprot id: H9ESU3
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9544:MGAT1
gene id: 9544:MGAT1
uniprot id: A0A8J8YLX1
uniprot id: G7MUK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9544:KCNF1
gene id: 9544:KCNF1
uniprot id: A0A8J8YMG1
uniprot id: G7NBA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:POLR3GL
gene id: 9544:POLR3GL
uniprot id: A0A8J8YI54
uniprot id: F6V5W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9544:KLC3
gene id: 9544:KLC3
uniprot id: F6TC28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9544:RFFL
gene id: 9544:RFFL
uniprot id: F6VB54
names: Subcellular Location Annotation
messages: Cell membrane
messages: cytosol

9544:APEH
gene id: 9544:APEH
uniprot id: F7G744
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.

9544:COG7
gene id: 9544:COG7
uniprot id: F7A3S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:TOMM5
gene id: 9544:TOMM5
uniprot id: F7F1V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

9544:PIM3
gene id: 9544:PIM3
uniprot id: H9EVF0
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9544:NDUFA12
gene id: 9544:NDUFA12
uniprot id: A0A1D5R6K9
uniprot id: A0A8J8Y4J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:ATP2A1
gene id: 9544:ATP2A1
uniprot id: G7NQG5
uniprot id: I2CX33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9544:TEKT3
gene id: 9544:TEKT3
uniprot id: A0A8J8XWX5
uniprot id: F6WEM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9544:PDCD5
gene id: 9544:PDCD5
uniprot id: F6S8R2
names: Similarity
messages: Belongs to the PDCD5 family.

9544:MAB21L2
gene id: 9544:MAB21L2
uniprot id: A0A1D5QJ29
names: Similarity
messages: Belongs to the mab-21 family.

9544:SUDS3
gene id: 9544:SUDS3
uniprot id: H9EPK1
names: Subcellular Location Annotation
messages: Nucleus

9544:APH1A
gene id: 9544:APH1A
uniprot id: A0A8J8XAV4
uniprot id: G7MDH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9544:PPP2R5E
gene id: 9544:PPP2R5E
uniprot id: A0A1D5QA20
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9544:TBPL1
gene id: 9544:TBPL1
uniprot id: A0A8J8XKY2
uniprot id: G7MQB7
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9544:EID1
gene id: 9544:EID1
uniprot id: H9FSA0
names: Subcellular Location Annotation
messages: Nucleus

9544:TSEN15
gene id: 9544:TSEN15
uniprot id: F7FYH4
names: Similarity
messages: Belongs to the SEN15 family.

9544:SLC45A3
gene id: 9544:SLC45A3
uniprot id: A0A8J8YB70
uniprot id: F6XTN2
names: Subcellular Location Annotation
messages: Membrane

9544:RPS18
gene id: 9544:RPS18
uniprot id: A0A8J8YPT9
uniprot id: G7N7R0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.

9544:GBX1
gene id: 9544:GBX1
uniprot id: A0A1D5QDX9
names: Subcellular Location Annotation
messages: Nucleus

9544:HSPB7
gene id: 9544:HSPB7
uniprot id: F7FWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9544:PIGV
gene id: 9544:PIGV
uniprot id: F7DX39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9544:MRPL27
gene id: 9544:MRPL27
uniprot id: H9Z9Q6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9544:TMCC3
gene id: 9544:TMCC3
uniprot id: A0A5F8APL4
names: Similarity
messages: Belongs to the TEX28 family.

9544:SMG8
gene id: 9544:SMG8
uniprot id: F7HS41
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

9544:MKNK2
gene id: 9544:MKNK2
uniprot id: H9EP11
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:EEF1D
gene id: 9544:EEF1D
uniprot id: F7GRR7
uniprot id: I0FPR4
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

9544:RRM1
gene id: 9544:RRM1
uniprot id: A0A8J8YB73
uniprot id: H9FY72
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9544:SMARCB1
gene id: 9544:SMARCB1
uniprot id: H9FYR5
uniprot id: H9FYR6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

9544:EVX1
gene id: 9544:EVX1
uniprot id: A0A5F7ZK39
names: Subcellular Location Annotation
messages: Nucleus

9544:ADCYAP1R1
gene id: 9544:ADCYAP1R1
uniprot id: A0A1D5QCN0
uniprot id: A0A1D5QU32
names: Subcellular Location Annotation
messages: Membrane

9544:FGD1
gene id: 9544:FGD1
uniprot id: I2CTY0
names: Subcellular Location Annotation
messages: cytoskeleton

9544:YPEL4
gene id: 9544:YPEL4
uniprot id: A0A1D5Q5U4
names: Similarity
messages: Belongs to the yippee family.

9544:CREBL2
gene id: 9544:CREBL2
uniprot id: H9EPG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9544:GAMT
gene id: 9544:GAMT
uniprot id: H9EWR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.
messages: Monomer.

9544:AMDHD1
gene id: 9544:AMDHD1
uniprot id: F7H1F5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

9544:HBS1L
gene id: 9544:HBS1L
uniprot id: F6RZZ7
names: Subcellular Location Annotation
messages: Cytoplasm

9544:NME5
gene id: 9544:NME5
uniprot id: A0A8J8YSA6
uniprot id: G7MUV9
names: Similarity
messages: Belongs to the NDK family.

9544:LOC714004
gene id: 9544:LOC714004
uniprot id: A0A1D5RIF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

9544:SNX5
gene id: 9544:SNX5
uniprot id: F6T1Z9
uniprot id: F7AE06
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9544:XKR8
gene id: 9544:XKR8
uniprot id: A0A5F8AN23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9544:FAM171B
gene id: 9544:FAM171B
uniprot id: H9FQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9544:STX7
gene id: 9544:STX7
uniprot id: A0A8J8YHK2
uniprot id: F7ATP9
names: Similarity
messages: Belongs to the syntaxin family.

9544:NDUFB5
gene id: 9544:NDUFB5
uniprot id: A0A8J8YM54
uniprot id: F6ZQ85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:CYSTM1
gene id: 9544:CYSTM1
uniprot id: A0A8J8YES8
uniprot id: F6YFX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

9544:MESD
gene id: 9544:MESD
uniprot id: A0A8J8Y6V5
uniprot id: G7MYN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9544:C1H1orf158
gene id: 9544:C1H1orf158
uniprot id: G7MH21
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9544:RP2
gene id: 9544:RP2
uniprot id: A0A8J8YNU5
uniprot id: G7NT32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9544:PPEF2
gene id: 9544:PPEF2
uniprot id: F6SFA1
names: Similarity
messages: Belongs to the PPP phosphatase family.

9544:DCST1
gene id: 9544:DCST1
uniprot id: F7EDE8
names: Subcellular Location Annotation
messages: Membrane

9544:NKIRAS2
gene id: 9544:NKIRAS2
uniprot id: A0A8J8XJC4
uniprot id: F7BYD9
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9544:SLC4A1
gene id: 9544:SLC4A1
uniprot id: F7H5B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

9544:FOXN4
gene id: 9544:FOXN4
uniprot id: F6UGC7
names: Subcellular Location Annotation
messages: Nucleus

9544:CLRN3
gene id: 9544:CLRN3
uniprot id: A0A8J8Y299
uniprot id: F7GCH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9544:TAS2R4
gene id: 9544:TAS2R4
uniprot id: Q645S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: cilium membrane

9544:TMEM120A
gene id: 9544:TMEM120A
uniprot id: I0FVJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9544:AP3D1
gene id: 9544:AP3D1
uniprot id: F6RCI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer.
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.

9544:PDPK1
gene id: 9544:PDPK1
uniprot id: H9ESX9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

9544:CES5A
gene id: 9544:CES5A
uniprot id: D0Z5M4
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9544:LOC721827
gene id: 9544:LOC721827
uniprot id: A0A5F7ZW09
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9544:SGTA
gene id: 9544:SGTA
uniprot id: F7FGF5
names: Similarity
messages: Belongs to the SGT family.

9544:C20H16orf58
gene id: 9544:C20H16orf58
uniprot id: F6REH0
names: Similarity
messages: Belongs to the RUS1 family.

9544:AMIGO3
gene id: 9544:AMIGO3
uniprot id: F7GRK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9544:UBE2T
gene id: 9544:UBE2T
uniprot id: H9EWW6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:SLC16A6
gene id: 9544:SLC16A6
uniprot id: A0A5K1UT92
uniprot id: A0A8J8XKV8
names: Subcellular Location Annotation
messages: Membrane

9544:RXRG
gene id: 9544:RXRG
uniprot id: A0A8J8YBP9
uniprot id: F7HDB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9544:HNF4G
gene id: 9544:HNF4G
uniprot id: A0A5F8ALS9
uniprot id: F7H2A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:RGS9BP
gene id: 9544:RGS9BP
uniprot id: A0A8J8XHL1
uniprot id: F6TNS0
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9544:CALCRL
gene id: 9544:CALCRL
uniprot id: F6X1C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9544:SAE1
gene id: 9544:SAE1
uniprot id: H9FND3
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9544:EXT1
gene id: 9544:EXT1
uniprot id: A0A8J8XGU3
uniprot id: F7F8Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ARHGAP26
gene id: 9544:ARHGAP26
uniprot id: I0FM37
uniprot id: I0FM38
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9544:SLC2A6
gene id: 9544:SLC2A6
uniprot id: A0A8J8XTL0
uniprot id: G7NF99
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9544:NF2
gene id: 9544:NF2
uniprot id: F6RPW5
uniprot id: F6RPZ9
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9544:VAMP4
gene id: 9544:VAMP4
uniprot id: A0A8J8YMI5
uniprot id: G7MFC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9544:PTPA
gene id: 9544:PTPA
uniprot id: H9FWM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9544:GPER1
gene id: 9544:GPER1
uniprot id: F7EQ49
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endoplasmic reticulum membrane
messages: Expressed in olfactory placode and LH-releasing hormone (LHRH) neurons (at protein level). Expressed in hypothalamus, cerebellum, olfactory placode and uterus.
messages: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transducti…
messages: Glycosylated.
messages: Golgi apparatus membrane
messages: Homodimer. Heterodimer; heterodimerizes with other G-protein-coupled receptor (GPCRs) like CRHR1, HTR1A and PAQR8. Interacts with RAMP3. Interacts with KRT7 and KRT8. Interacts with EGFR; the interaction increases after agonist-induced stimulation in cancer-associated fibroblasts (CAF). Interacts with EGFR and ESR1. Interacts (via C-terminus tail motif) with DLG4 (via N-terminus tandem pair of PDZ domains); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (By similarity).
messages: Mitochondrion membrane
messages: Nucleus
messages: Postsynaptic density
messages: Recycling endosome
messages: Ubiquitinated; ubiquitination occurs at the plasma membrane and leads to proteasome-mediated degradation.
messages: axon
messages: cytoskeleton
messages: dendrite
messages: dendritic spine membrane
messages: perinuclear region
messages: trans-Golgi network

9544:CCL8
gene id: 9544:CCL8
uniprot id: Q8HYQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:TIMM44
gene id: 9544:TIMM44
uniprot id: F7HS29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

9544:LYNX1
gene id: 9544:LYNX1
uniprot id: A0A5F7ZL24
uniprot id: P0DP62
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR. In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs. Prevents plasticity in the primary visual cortex late in life.
messages: Cell membrane
messages: Detected as early as day 71 of gestation. Expression increases consistently in lungs throughout the prenatal period. After birth, expression continues well into adulthood. At 71 days of gestation (pseudoglandular phase), expression is detected in tracheal and proximal conducting airway epithelium. Expression decreases gradually toward the distal airways. Strong expression in the epithelium lining the tips of the dichotomous and monopodial airway buds. Weakly expressed in smooth muscle cells around the large airways. Weakly expressed in mesenchymal cells and not at all in the mesenchymal cells surrounding the airway buds. Not detected in vessels associated with large airways (at protein level). At 94 days of gestation, similar expression pattern, but expression increases and extends toward distal airway epithelium. Strong expression in type II cells that line the primitive air spaces of late canalicular and early saccular phase. More prominent expression in the smooth muscle cells surrounding the large airways. Begins to be weakly expressed in endothelial and smooth muscle cells in large vessels, but not in small distal vessels (at protein level). At day 134 of gestation, further increase in expression in the distal airway epithelium. In large airways, predominantly expressed in the ciliated epithelium. Expressed at low levels in the mucus-secreting cells and at high levels in the submucosal gland cells. Weakly expressed in paracartilaginous cells, but not in cells in the extra-cartilaginous layer. Not detected in type I alveolar cells. Strongly expressed in endothelial and smooth muscle cells increased in large vessels and in distal vessels (at protein level). At birth, similar pattern of expression. Slightly decreased expression in the proximal airways (at protein level).
messages: Endoplasmic reticulum
messages: Expressed in lung predominantly in airway epithelial cells, submucous glands, and smooth muscle cells, in endothelial and smooth muscle cells in vessel walls and in alveolar type II cells (at protein level). Also expressed in brain.
messages: Interacts with nAChRs containing alpha-4:beta-2 (CHRNA4:CHRNB2) and alpha-7 (CHRNA7) subunits. Interacts with CHRNA4 probably in the endoplasmic reticulum prior to nAChR pentameric assembly.
messages: Membrane
messages: Up-regulated by prenatal nicotine exposure.
messages: dendrite

9544:KEG06 p02
gene id: 9544:KEG06_p02
uniprot id: Q6IYG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9544:ZSCAN22
gene id: 9544:ZSCAN22
uniprot id: F7H1A1
names: Subcellular Location Annotation
messages: Nucleus

9544:PRPS1L1
gene id: 9544:PRPS1L1
uniprot id: A0A5F8A181
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9544:SERPINH1
gene id: 9544:SERPINH1
uniprot id: F7D5P2
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

9544:EIPR1
gene id: 9544:EIPR1
uniprot id: A0A5F7ZHZ1
uniprot id: A0A5F8A2R0
uniprot id: H9FZ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

9544:KDM6A
gene id: 9544:KDM6A
uniprot id: A0A1D5Q6W5
uniprot id: A0A1D5QEA4
uniprot id: A0A5F8A1Y9
uniprot id: F7BRN8
uniprot id: F7EHL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTX family.
messages: Nucleus

9544:IPPK
gene id: 9544:IPPK
uniprot id: A0A8J8XJE4
uniprot id: F6TD69
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9544:COG1
gene id: 9544:COG1
uniprot id: F7C2K0
names: Similarity
messages: Belongs to the COG1 family.

9544:STOM
gene id: 9544:STOM
uniprot id: H9Z680
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9544:ID1
gene id: 9544:ID1
uniprot id: F7GUC3
names: Subcellular Location Annotation
messages: Nucleus

9544:LOC696076
gene id: 9544:LOC696076
uniprot id: A0A5F7ZLK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:EBF3
gene id: 9544:EBF3
uniprot id: A0A5F8AHX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9544:THAP1
gene id: 9544:THAP1
uniprot id: H9FWI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9544:NDUFA8
gene id: 9544:NDUFA8
uniprot id: A0A5F8AMN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9544:IFNG
gene id: 9544:IFNG
uniprot id: G7N7K9
uniprot id: P63310
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Released primarily from activated T lymphocytes.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9544:PTGES
gene id: 9544:PTGES
uniprot id: A0A8J8YEY0
uniprot id: G7NFJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9544:ST6GALNAC4
gene id: 9544:ST6GALNAC4
uniprot id: A0A5K1V2V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:ADRB3
gene id: 9544:ADRB3
uniprot id: Q28524
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
messages: Cell membrane
messages: Interacts with ARRDC3.

9544:UPK1A
gene id: 9544:UPK1A
uniprot id: F7HHP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:UCP2
gene id: 9544:UCP2
uniprot id: F7H9F2
uniprot id: Q9N1D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:CSNK1G2
gene id: 9544:CSNK1G2
uniprot id: H9EP27
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9544:USP16
gene id: 9544:USP16
uniprot id: I0FNJ5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9544:AK1
gene id: 9544:AK1
uniprot id: F6TT84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

9544:SLC25A12
gene id: 9544:SLC25A12
uniprot id: A0A1D5RFL8
uniprot id: F7F2U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:CSTF2T
gene id: 9544:CSTF2T
uniprot id: F7G3K9
names: Subcellular Location Annotation
messages: Nucleus

9544:PRUNE1
gene id: 9544:PRUNE1
uniprot id: A0A8J8YMN8
uniprot id: F6T7I7
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9544:PLPPR4
gene id: 9544:PLPPR4
uniprot id: F7HG58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:ADSL
gene id: 9544:ADSL
uniprot id: H9Z5Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

9544:ABCD1
gene id: 9544:ABCD1
uniprot id: F7ENC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9544:RAB19
gene id: 9544:RAB19
uniprot id: F7CXP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

9544:CAMK2N2
gene id: 9544:CAMK2N2
uniprot id: F6YD54
names: Similarity
messages: Belongs to the CAMK2N family.

9544:DLST
gene id: 9544:DLST
uniprot id: A0A8J8Y7H4
uniprot id: F6YNF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9544:B3GNT2
gene id: 9544:B3GNT2
uniprot id: A0A8J8YD38
uniprot id: F7AT08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:USP14
gene id: 9544:USP14
uniprot id: A0A1D5QG07
uniprot id: F7AFL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9544:PTTG1
gene id: 9544:PTTG1
uniprot id: F6UYK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9544:MS4A8
gene id: 9544:MS4A8
uniprot id: G7ND36
names: Similarity
messages: Belongs to the MS4A family.

9544:SIGMAR1
gene id: 9544:SIGMAR1
uniprot id: A0A8J8YNH2
uniprot id: F7HC83
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle
messages: growth cone

9544:FZR1
gene id: 9544:FZR1
uniprot id: A0A8J8YGB6
uniprot id: F7GTB6
uniprot id: G7NLU2
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9544:ARSD
gene id: 9544:ARSD
uniprot id: H9H4P4
names: Similarity
messages: Belongs to the sulfatase family.

9544:SOD2
gene id: 9544:SOD2
uniprot id: H9EUV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

9544:RPL27
gene id: 9544:RPL27
uniprot id: F7GZ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9544:UBXN1
gene id: 9544:UBXN1
uniprot id: A0A8J8XE86
uniprot id: F6W1K5
uniprot id: H9Z9J6
names: Subcellular Location Annotation
messages: Cytoplasm

9544:LOC100426632
gene id: 9544:LOC100426632
uniprot id: F7HIT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:NR1H3
gene id: 9544:NR1H3
uniprot id: F6ST28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9544:SEMA6C
gene id: 9544:SEMA6C
uniprot id: F7AIQ7
uniprot id: I2CVL4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:RAB29
gene id: 9544:RAB29
uniprot id: A0A8J8XW67
uniprot id: G7MES5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9544:FXYD6
gene id: 9544:FXYD6
uniprot id: A0A5F8A3G6
uniprot id: A0A8J8YLS9
uniprot id: I0FSP6
names: Similarity
messages: Belongs to the FXYD family.

9544:RRAGA
gene id: 9544:RRAGA
uniprot id: A0A8J8XJQ4
uniprot id: G7NFY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9544:EMG1
gene id: 9544:EMG1
uniprot id: A0A8J8Y867
uniprot id: I0FN01
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9544:TLE2
gene id: 9544:TLE2
uniprot id: I2CYU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9544:RAB9B
gene id: 9544:RAB9B
uniprot id: A0A8J8YG04
uniprot id: F6WKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9544:SMIM12
gene id: 9544:SMIM12
uniprot id: H9ENZ6
names: Similarity
messages: Belongs to the SMIM12 family.

9544:GAD1
gene id: 9544:GAD1
uniprot id: A0A8J8YFI2
uniprot id: G7N8A4
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9544:PSMA4
gene id: 9544:PSMA4
uniprot id: A0A1D5QLV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9544:SLC33A1
gene id: 9544:SLC33A1
uniprot id: A0A8J8YQZ6
uniprot id: G7MJG2
names: Subcellular Location Annotation
messages: Membrane

9544:DLGAP4
gene id: 9544:DLGAP4
uniprot id: F7GF82
names: Similarity
messages: Belongs to the SAPAP family.

9544:ZAR1
gene id: 9544:ZAR1
uniprot id: A0A5F7ZL21
names: Similarity
names: Subunit
messages: Belongs to the ZAR1 family.
messages: Interacts with YBX2.

9544:ACER2
gene id: 9544:ACER2
uniprot id: A0A8J8YJN2
uniprot id: G7NFX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:OSGEP
gene id: 9544:OSGEP
uniprot id: A0A8J8XC35
uniprot id: F7FCR0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

9544:LRP4
gene id: 9544:LRP4
uniprot id: H9FUD8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:GNMT
gene id: 9544:GNMT
uniprot id: A0A8J8XRQ8
uniprot id: F7CZP8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9544:LOC699231
gene id: 9544:LOC699231
uniprot id: F6QAX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9544:MT2A
gene id: 9544:MT2A
uniprot id: A0A8J8Y2M7
uniprot id: G7NPC6
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:NXF1
gene id: 9544:NXF1
uniprot id: H9YW98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9544:CISD2
gene id: 9544:CISD2
uniprot id: A0A8J8XK56
uniprot id: F6URX4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CISD protein family. CISD2 subfamily.
messages: Binds 1 [2Fe-2S] cluster.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Mitochondrion outer membrane
messages: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy.

9544:C6orf125
gene id: 9544:C6orf125
uniprot id: H9G0P9
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9544:RSL24D1
gene id: 9544:RSL24D1
uniprot id: F6PJJ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9544:UBA6
gene id: 9544:UBA6
uniprot id: H9FWM4
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9544:OPRPN
gene id: 9544:OPRPN
uniprot id: F6UDQ3
names: Subcellular Location Annotation
messages: Secreted

9544:SNX17
gene id: 9544:SNX17
uniprot id: A0A1D5QIM9
uniprot id: A0A8J8XY19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9544:TMEM198
gene id: 9544:TMEM198
uniprot id: A0A8J8Y6B1
uniprot id: H9EU83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9544:METAP1
gene id: 9544:METAP1
uniprot id: F7GMH6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9544:VANGL2
gene id: 9544:VANGL2
uniprot id: A0A8J8XIN7
uniprot id: F6WWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9544:CFLAR
gene id: 9544:CFLAR
uniprot id: A0A8J8XP41
uniprot id: H9FN52
names: Similarity
messages: Belongs to the peptidase C14A family.

9544:ASB9
gene id: 9544:ASB9
uniprot id: F7AW27
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:HAPLN3
gene id: 9544:HAPLN3
uniprot id: F6ZXE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:RAD23B
gene id: 9544:RAD23B
uniprot id: H9YX93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9544:GRIN3A
gene id: 9544:GRIN3A
uniprot id: F6VTB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9544:ZIC1
gene id: 9544:ZIC1
uniprot id: F6SUA1
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9544:UQCRC2
gene id: 9544:UQCRC2
uniprot id: F7HJV7
names: Similarity
messages: Belongs to the peptidase M16 family.

9544:SBNO1
gene id: 9544:SBNO1
uniprot id: G7N694
uniprot id: I0FT20
names: Similarity
messages: Belongs to the SBNO family.

9544:TP63
gene id: 9544:TP63
uniprot id: A0A8J8YAQ1
uniprot id: F7FN59
uniprot id: F7FN64
uniprot id: F7GBG3
uniprot id: F7GBG7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Nucleus

9544:FARSA
gene id: 9544:FARSA
uniprot id: A0A8J8XV29
uniprot id: H9Z2H3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

9544:SNRPD2
gene id: 9544:SNRPD2
uniprot id: H9Z0C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: cytosol

9544:SLC25A21
gene id: 9544:SLC25A21
uniprot id: A0A8J8XMM5
uniprot id: G7MXM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:PRKCZ
gene id: 9544:PRKCZ
uniprot id: F6ZZK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9544:CLCA2
gene id: 9544:CLCA2
uniprot id: G7MHU0
names: Similarity
messages: Belongs to the CLCR family.

9544:PIWIL3
gene id: 9544:PIWIL3
uniprot id: E1AXB6
names: Similarity
messages: Belongs to the argonaute family.

9544:BAAT
gene id: 9544:BAAT
uniprot id: A0A5F8A314
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9544:PICALM
gene id: 9544:PICALM
uniprot id: H9G0D3
uniprot id: H9G0D4
uniprot id: H9G0D5
uniprot id: H9ZE41
uniprot id: H9ZE43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9544:ASXL1
gene id: 9544:ASXL1
uniprot id: H9Z5X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9544:SH3YL1
gene id: 9544:SH3YL1
uniprot id: F7HJ32
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9544:PSMC1
gene id: 9544:PSMC1
uniprot id: I0FTL2
names: Similarity
messages: Belongs to the AAA ATPase family.

9544:MLST8
gene id: 9544:MLST8
uniprot id: H9FYD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9544:BPGM
gene id: 9544:BPGM
uniprot id: A0A8J8YL24
uniprot id: H9ER39
uniprot id: I0FUG9
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9544:STARD5
gene id: 9544:STARD5
uniprot id: A0A5F8A100
uniprot id: A0A8J8Y1S3
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9544:PRDX1
gene id: 9544:PRDX1
uniprot id: A0A8J8YHI3
uniprot id: G7MGP8
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9544:EFNA1
gene id: 9544:EFNA1
uniprot id: A0A5F8AJF3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:ACSL4
gene id: 9544:ACSL4
uniprot id: A0A5F8A496
uniprot id: A0A8J8YQC9
uniprot id: F6Z9U8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:SNX1
gene id: 9544:SNX1
uniprot id: F6QIL5
uniprot id: F7FZ40
uniprot id: I0FUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9544:SH3GL2
gene id: 9544:SH3GL2
uniprot id: A0A5F7ZEZ3
uniprot id: F7HCC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9544:PRKACB
gene id: 9544:PRKACB
uniprot id: A0A1D5QFQ7
uniprot id: A0A1D5RCW7
uniprot id: A0A5K1UDP0
uniprot id: F7EBR0
uniprot id: F7EBR5
uniprot id: H9FWY1
uniprot id: H9FWY2
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9544:FAM214B
gene id: 9544:FAM214B
uniprot id: A0A8J8XEW6
uniprot id: F7H2R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9544:PI4K2B
gene id: 9544:PI4K2B
uniprot id: F6Q6T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9544:ANXA5
gene id: 9544:ANXA5
uniprot id: A0A5F8AR19
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9544:CCNA1
gene id: 9544:CCNA1
uniprot id: F6RGI5
uniprot id: H9G1E4
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9544:IRF9
gene id: 9544:IRF9
uniprot id: A0A8J8YMM8
uniprot id: G7MX63
names: Subcellular Location Annotation
messages: Nucleus

9544:TRIM7
gene id: 9544:TRIM7
uniprot id: F7EMK3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:LOC704066
gene id: 9544:LOC704066
uniprot id: I2CYE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:LHX5
gene id: 9544:LHX5
uniprot id: A0A5F7ZB76
names: Subcellular Location Annotation
messages: Nucleus

9544:PLPP3
gene id: 9544:PLPP3
uniprot id: H9G166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:SH3GLB1
gene id: 9544:SH3GLB1
uniprot id: A0A1D5Q796
uniprot id: A0A1D5QE68
uniprot id: A0A8J8XBY1
uniprot id: F6ZLB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9544:CDV3
gene id: 9544:CDV3
uniprot id: F7HMA2
uniprot id: H9ZAZ5
names: Similarity
messages: Belongs to the CDV3 family.

9544:SLC52A2
gene id: 9544:SLC52A2
uniprot id: G7N0B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9544:SLC7A14
gene id: 9544:SLC7A14
uniprot id: A0A8J8XU75
uniprot id: F6RYL9
names: Subcellular Location Annotation
messages: Membrane

9544:EPHA8
gene id: 9544:EPHA8
uniprot id: F7HEL6
names: Subcellular Location Annotation
messages: Membrane

9544:SPNS1
gene id: 9544:SPNS1
uniprot id: A0A8J8XJR0
uniprot id: F7EV02
uniprot id: G7NQG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9544:LOC708065
gene id: 9544:LOC708065
uniprot id: I2CWI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion inner membrane

9544:ACTRT2
gene id: 9544:ACTRT2
uniprot id: A0A8J8YR26
uniprot id: F7FHH3
names: Similarity
messages: Belongs to the actin family.

9544:FGF14
gene id: 9544:FGF14
uniprot id: A0A5F7ZDL3
uniprot id: F7HFS0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:TOLLIP
gene id: 9544:TOLLIP
uniprot id: A0A1D5RG89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9544:PIK3CB
gene id: 9544:PIK3CB
uniprot id: A0A8J8XK18
uniprot id: F7F3S0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9544:PTPN11
gene id: 9544:PTPN11
uniprot id: H9FXT1
uniprot id: H9Z053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9544:LOC706480
gene id: 9544:LOC706480
uniprot id: F7BMC8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:LY6D
gene id: 9544:LY6D
uniprot id: G7N076
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:HMGN4
gene id: 9544:HMGN4
uniprot id: A0A8J8XT83
uniprot id: F7B025
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9544:MON2
gene id: 9544:MON2
uniprot id: F6WNT8
uniprot id: H9FRL8
names: Similarity
messages: Belongs to the MON2 family.

9544:TMEM245
gene id: 9544:TMEM245
uniprot id: A0A1D5R7V2
uniprot id: F7HG68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

9544:SF3B4
gene id: 9544:SF3B4
uniprot id: F7FGV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9544:VSX2
gene id: 9544:VSX2
uniprot id: F7AP06
names: Subcellular Location Annotation
messages: Nucleus

9544:TUBA1B
gene id: 9544:TUBA1B
uniprot id: F7HU50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9544:MFRP
gene id: 9544:MFRP
uniprot id: G7NCK8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:DGKB
gene id: 9544:DGKB
uniprot id: A0A5F8A472
uniprot id: H9FQL5
uniprot id: H9FQL9
uniprot id: I2CTX4
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9544:ZDHHC22
gene id: 9544:ZDHHC22
uniprot id: A0A8J8YN37
uniprot id: G7MYW0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:RCAN2
gene id: 9544:RCAN2
uniprot id: A0A8J8YIF9
uniprot id: F6QGB6
uniprot id: F6QGC6
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9544:CPE
gene id: 9544:CPE
uniprot id: F7FE30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Interacts with Secretogranin III/SCG3.
messages: Membrane
messages: Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
messages: secretory vesicle membrane

9544:SCAMP2
gene id: 9544:SCAMP2
uniprot id: H9FND7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9544:NR2F1
gene id: 9544:NR2F1
uniprot id: I2CYU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:PURG
gene id: 9544:PURG
uniprot id: I0FR81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9544:RDH8
gene id: 9544:RDH8
uniprot id: F6URW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

9544:LCOR
gene id: 9544:LCOR
uniprot id: A0A8J8YBR6
uniprot id: G7N2N5
names: Subcellular Location Annotation
messages: Nucleus

9544:CCHCR1
gene id: 9544:CCHCR1
uniprot id: Q5TM47
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9544:SLC25A4
gene id: 9544:SLC25A4
uniprot id: F6QA37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9544:SLC39A1
gene id: 9544:SLC39A1
uniprot id: F6VJG8
uniprot id: F7AMB0
names: Subcellular Location Annotation
messages: Membrane

9544:H2AFB3
gene id: 9544:H2AFB3
uniprot id: H9H3C2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:GTF2H2
gene id: 9544:GTF2H2
uniprot id: A0A8J8XNQ4
uniprot id: G7MU86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9544:SUPT4H1
gene id: 9544:SUPT4H1
uniprot id: A0A8J8XCI3
uniprot id: F6SS75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9544:TMEM183A
gene id: 9544:TMEM183A
uniprot id: H9ZFD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

9544:CMKLR1
gene id: 9544:CMKLR1
uniprot id: A0A1D5QAH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9544:LOC704334
gene id: 9544:LOC704334
uniprot id: A0A8J8XLQ4
uniprot id: F6WQL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9544:DYRK2
gene id: 9544:DYRK2
uniprot id: F6PT02
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9544:SLC35F2
gene id: 9544:SLC35F2
uniprot id: A0A8J8Y2V3
uniprot id: G7NBT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9544:KCNH5
gene id: 9544:KCNH5
uniprot id: A0A8J8YCG0
uniprot id: F7DXE4
names: Subcellular Location Annotation
messages: Membrane

9544:SATB1
gene id: 9544:SATB1
uniprot id: F6XW50
uniprot id: I2CY91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9544:ELOC
gene id: 9544:ELOC
uniprot id: I0FUL6
names: Similarity
messages: Belongs to the SKP1 family.

9544:POLR2B
gene id: 9544:POLR2B
uniprot id: F6QI47
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9544:ILKAP
gene id: 9544:ILKAP
uniprot id: H9YY70
names: Similarity
messages: Belongs to the PP2C family.

9544:RPP30
gene id: 9544:RPP30
uniprot id: A0A5F7ZU43
uniprot id: A0A8J8YLH5
uniprot id: F7H469
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9544:FAM3B
gene id: 9544:FAM3B
uniprot id: F6YNL3
uniprot id: F6YP54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9544:GAST
gene id: 9544:GAST
uniprot id: F6YAX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9544:RNF8
gene id: 9544:RNF8
uniprot id: F7BPD6
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9544:TRAPPC3
gene id: 9544:TRAPPC3
uniprot id: A0A1D5Q8B3
uniprot id: A0A8J8XK89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9544:WNT16
gene id: 9544:WNT16
uniprot id: A0A8J8YEN5
uniprot id: F6PJR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:MEP1B
gene id: 9544:MEP1B
uniprot id: F6VMK0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:GLRA2
gene id: 9544:GLRA2
uniprot id: A0A5F8AP75
uniprot id: F7E7T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9544:GGA1
gene id: 9544:GGA1
uniprot id: H9FSR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9544:REN
gene id: 9544:REN
uniprot id: Q6DLW5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.
messages: Interacts with ATP6AP2.
messages: Membrane
messages: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
messages: Secreted

9544:DYNLL2
gene id: 9544:DYNLL2
uniprot id: H9ELW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9544:SLC35E4
gene id: 9544:SLC35E4
uniprot id: A0A8J8XX74
uniprot id: G7N3L8
names: Subcellular Location Annotation
messages: Membrane

9544:LDB2
gene id: 9544:LDB2
uniprot id: A0A8J8YPD2
uniprot id: G7MSM2
uniprot id: H9G1K8
names: Similarity
messages: Belongs to the LDB family.

9544:TIMM8B
gene id: 9544:TIMM8B
uniprot id: A0A663DIL8
uniprot id: G7NC17
uniprot id: H9Z7N7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9544:ALG2
gene id: 9544:ALG2
uniprot id: F7B5N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

9544:GCLC
gene id: 9544:GCLC
uniprot id: A0A1D5QEN7
uniprot id: A0A8J8Y0S5
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9544:NRDC
gene id: 9544:NRDC
uniprot id: H9FUZ3
names: Similarity
messages: Belongs to the peptidase M16 family.

9544:BET1L
gene id: 9544:BET1L
uniprot id: A0A8J8Y8A6
uniprot id: H9FN01
names: Subcellular Location Annotation
messages: Membrane

9544:YARS2
gene id: 9544:YARS2
uniprot id: H9H3M7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:WNT3A
gene id: 9544:WNT3A
uniprot id: F7CJE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:ID4
gene id: 9544:ID4
uniprot id: F7GTT4
names: Subcellular Location Annotation
messages: Nucleus

9544:CHST11
gene id: 9544:CHST11
uniprot id: A0A8J8YLH7
uniprot id: H9Z9G6
uniprot id: H9Z9G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:SULT4A1
gene id: 9544:SULT4A1
uniprot id: F7BQJ9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9544:LMNA
gene id: 9544:LMNA
uniprot id: A0A8J8XKC0
uniprot id: F6W890
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9544:COPE
gene id: 9544:COPE
uniprot id: I0FNY4
uniprot id: I0FNY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9544:TMBIM1
gene id: 9544:TMBIM1
uniprot id: F6UPC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9544:NUP58
gene id: 9544:NUP58
uniprot id: H9ET58
uniprot id: I0FWT4
names: Subcellular Location Annotation
messages: nuclear pore complex

9544:NASP
gene id: 9544:NASP
uniprot id: H9EW48
uniprot id: H9FUS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9544:TCP11L1
gene id: 9544:TCP11L1
uniprot id: A0A8J8YGN4
uniprot id: F6QCY5
names: Similarity
messages: Belongs to the TCP11 family.

9544:GML
gene id: 9544:GML
uniprot id: A0A8J8YJZ5
uniprot id: G7N077
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:FAM102B
gene id: 9544:FAM102B
uniprot id: G8F1S0
uniprot id: I0FHW6
names: Similarity
messages: Belongs to the EEIG family.

9544:VILL
gene id: 9544:VILL
uniprot id: F6SRR3
names: Similarity
messages: Belongs to the villin/gelsolin family.

9544:MED21
gene id: 9544:MED21
uniprot id: F7DXW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9544:NCDN
gene id: 9544:NCDN
uniprot id: A0A5F7ZNW9
uniprot id: A0A8J8XP80
uniprot id: F7GQH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

9544:TMEM214
gene id: 9544:TMEM214
uniprot id: H9ZAH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:HSPA13
gene id: 9544:HSPA13
uniprot id: I0FIJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

9544:CTNNA1
gene id: 9544:CTNNA1
uniprot id: H9Z5L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9544:UCKL1
gene id: 9544:UCKL1
uniprot id: I0FIN0
names: Similarity
messages: Belongs to the uridine kinase family.

9544:UGGT1
gene id: 9544:UGGT1
uniprot id: F7DV55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9544:GCG
gene id: 9544:GCG
uniprot id: A0A5F8A440
names: Similarity
messages: Belongs to the glucagon family.

9544:G0S2
gene id: 9544:G0S2
uniprot id: A0A8J8XDK2
uniprot id: G7MEP0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.
messages: Mitochondrion
messages: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

9544:EIF4EBP2
gene id: 9544:EIF4EBP2
uniprot id: F7FDD1
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9544:UTP23
gene id: 9544:UTP23
uniprot id: F6YGH7
names: Subcellular Location Annotation
messages: nucleolus

9544:PSMD11
gene id: 9544:PSMD11
uniprot id: A0A8J8XJC8
uniprot id: G7NGU5
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9544:IL4
gene id: 9544:IL4
uniprot id: A0A8J8XF11
uniprot id: Q6U8C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
messages: Secreted

9544:AMT
gene id: 9544:AMT
uniprot id: A0A1D5QX71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9544:UBALD2
gene id: 9544:UBALD2
uniprot id: F7EXU9
names: Similarity
messages: Belongs to the UBALD family.

9544:SLC34A1
gene id: 9544:SLC34A1
uniprot id: A0A1D5R1A3
uniprot id: A0A8J8YML6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9544:SNX13
gene id: 9544:SNX13
uniprot id: F6WJA8
names: Similarity
messages: Belongs to the sorting nexin family.

9544:EGFL8
gene id: 9544:EGFL8
uniprot id: G7MRM5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:LEO1
gene id: 9544:LEO1
uniprot id: H9EU16
names: Similarity
messages: Belongs to the LEO1 family.

9544:MAP1LC3B
gene id: 9544:MAP1LC3B
uniprot id: A0A5F7ZX57
uniprot id: I2CT89
names: Similarity
messages: Belongs to the ATG8 family.

9544:KCNAB2
gene id: 9544:KCNAB2
uniprot id: F7C3Q4
uniprot id: H9Z2J9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: Monomer.
messages: axon
messages: cytoskeleton
messages: synaptosome

9544:MAN2A1
gene id: 9544:MAN2A1
uniprot id: H9EVC7
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9544:UBA3
gene id: 9544:UBA3
uniprot id: F7FCV2
uniprot id: F7FCV8
uniprot id: H9YUH8
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9544:TRAF3
gene id: 9544:TRAF3
uniprot id: A0A1D5RF63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9544:NIPSNAP3B
gene id: 9544:NIPSNAP3B
uniprot id: A0A1D5QMY7
names: Similarity
messages: Belongs to the NipSnap family.

9544:XRCC5
gene id: 9544:XRCC5
uniprot id: H9FZF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

9544:FOXI1
gene id: 9544:FOXI1
uniprot id: F7C1T8
names: Subcellular Location Annotation
messages: Nucleus

9544:S100PBP
gene id: 9544:S100PBP
uniprot id: A0A5K1VEI4
uniprot id: F6YVA3
names: Subcellular Location Annotation
messages: Nucleus

9544:TLL2
gene id: 9544:TLL2
uniprot id: F7CEL9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:YBEY
gene id: 9544:YBEY
uniprot id: F6S0T8
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9544:POLR2A
gene id: 9544:POLR2A
uniprot id: A0A1D5RJ13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9544:RPS6KA2
gene id: 9544:RPS6KA2
uniprot id: A0A1D5QGV7
uniprot id: H9FY70
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9544:PDE1A
gene id: 9544:PDE1A
uniprot id: H9FVG2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:ACTN4
gene id: 9544:ACTN4
uniprot id: A0A1D5QZ63
uniprot id: A0A1D5R031
uniprot id: H9G071
names: Similarity
messages: Belongs to the alpha-actinin family.

9544:ORMDL2
gene id: 9544:ORMDL2
uniprot id: A0A8J8XHH1
uniprot id: G7N7A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9544:LOC100429346
gene id: 9544:LOC100429346
uniprot id: F7HLG5
uniprot id: H9ENX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9544:PARG
gene id: 9544:PARG
uniprot id: H9EV41
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9544:KCNE5
gene id: 9544:KCNE5
uniprot id: A0A5F8AEK7
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9544:NR1I2
gene id: 9544:NR1I2
uniprot id: Q8SQ01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Heterodimer with RXRA (By similarity). Interacts with NCOA1 (By similarity). Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity).
messages: Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity).
messages: Nucleus

9544:NSDHL
gene id: 9544:NSDHL
uniprot id: F7GKA1
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9544:TUFM
gene id: 9544:TUFM
uniprot id: A0A8J8YBM1
uniprot id: H9FZ92
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9544:COPS5
gene id: 9544:COPS5
uniprot id: A0A8J8YIR5
uniprot id: F7H142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9544:DNAJC24
gene id: 9544:DNAJC24
uniprot id: A0A8J8XVC9
uniprot id: G7NDN8
names: Similarity
messages: Belongs to the DPH4 family.

9544:ARPC1B
gene id: 9544:ARPC1B
uniprot id: A0A8J8Y7Z1
uniprot id: G7MNQ9
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9544:NIF3L1
gene id: 9544:NIF3L1
uniprot id: A0A8J8YGH5
uniprot id: F7B590
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9544:DHRS7
gene id: 9544:DHRS7
uniprot id: A0A5F8AVE4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:ATP2B4
gene id: 9544:ATP2B4
uniprot id: A0A5F8ABU2
uniprot id: A0A5K1UV41
uniprot id: F7HU67
uniprot id: Q5BN38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:FGR
gene id: 9544:FGR
uniprot id: A0A8J8XD25
uniprot id: F7BHF8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9544:POU4F3
gene id: 9544:POU4F3
uniprot id: F6XDC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9544:FBLN1
gene id: 9544:FBLN1
uniprot id: A0A1D5R7Z0
uniprot id: F6PLV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:NRXN2
gene id: 9544:NRXN2
uniprot id: F6Z7H4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TMEM56
gene id: 9544:TMEM56
uniprot id: A0A8J8YM51
uniprot id: H9FQC9
names: Subcellular Location Annotation
messages: Membrane

9544:SLITRK2
gene id: 9544:SLITRK2
uniprot id: A0A8J8XN12
uniprot id: G7NRX2
names: Similarity
messages: Belongs to the SLITRK family.

9544:STX10
gene id: 9544:STX10
uniprot id: A0A8J8XRN1
uniprot id: H9ZER9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9544:UGDH
gene id: 9544:UGDH
uniprot id: A0A1D5Q620
uniprot id: A0A8J8XHN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9544:MFSD14A
gene id: 9544:MFSD14A
uniprot id: H9FYH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9544:LOC735307
gene id: 9544:LOC735307
uniprot id: Q07367
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9544:TPPP
gene id: 9544:TPPP
uniprot id: F6YD17
names: Similarity
messages: Belongs to the TPPP family.

9544:SLC39A5
gene id: 9544:SLC39A5
uniprot id: A0A8J8Y039
uniprot id: F7F3B2
names: Subcellular Location Annotation
messages: Membrane

9544:AP3M2
gene id: 9544:AP3M2
uniprot id: A0A8J8XPL8
uniprot id: G7MZ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9544:IL21
gene id: 9544:IL21
uniprot id: A0A8J8YD11
uniprot id: F7EGQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9544:YWHAB
gene id: 9544:YWHAB
uniprot id: F6XFG9
names: Similarity
messages: Belongs to the 14-3-3 family.

9544:MMP25
gene id: 9544:MMP25
uniprot id: F6YUR1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9544:TNP2
gene id: 9544:TNP2
uniprot id: B3LF37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: nucleolus

9544:CCNC
gene id: 9544:CCNC
uniprot id: A0A1D5Q0W7
uniprot id: H9EQS1
names: Similarity
messages: Belongs to the cyclin family.

9544:ELK1
gene id: 9544:ELK1
uniprot id: F6R9C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:AMOTL1
gene id: 9544:AMOTL1
uniprot id: A0A5F7ZKS8
names: Similarity
messages: Belongs to the angiomotin family.

9544:HMOX2
gene id: 9544:HMOX2
uniprot id: A0A8J8YAB9
uniprot id: I0FKU7
names: Similarity
messages: Belongs to the heme oxygenase family.

9544:GALNT16
gene id: 9544:GALNT16
uniprot id: F7AFB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:RNF121
gene id: 9544:RNF121
uniprot id: G7NE82
names: Subcellular Location Annotation
messages: Membrane

9544:TPM2
gene id: 9544:TPM2
uniprot id: F7GSX6
uniprot id: H9FZ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9544:EFEMP1
gene id: 9544:EFEMP1
uniprot id: A0A8J8Y7K4
uniprot id: G7NA36
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CD59
gene id: 9544:CD59
uniprot id: A0A8J8XK53
uniprot id: F6QCT1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:GSTM4
gene id: 9544:GSTM4
uniprot id: A0A023JCG3
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9544:GALNTL6
gene id: 9544:GALNTL6
uniprot id: A0A8J8Y954
uniprot id: F7DBP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:CACUL1
gene id: 9544:CACUL1
uniprot id: A0A8J8XDT5
uniprot id: I0FHI2
names: Similarity
messages: Belongs to the cullin family.

9544:LOC106995770
gene id: 9544:LOC106995770
uniprot id: I0FUI5
names: Similarity
messages: Belongs to the SSX family.

9544:MARF1
gene id: 9544:MARF1
uniprot id: A0A8J8Y2Q4
uniprot id: F7EVN5
names: Subcellular Location Annotation
messages: Peroxisome

9544:KRT72
gene id: 9544:KRT72
uniprot id: A0A1D5RD41
names: Similarity
messages: Belongs to the intermediate filament family.

9544:DDX58
gene id: 9544:DDX58
uniprot id: Q0PXR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9544:GDF6
gene id: 9544:GDF6
uniprot id: A0A5F7ZJV3
names: Similarity
messages: Belongs to the TGF-beta family.

9544:TIPRL
gene id: 9544:TIPRL
uniprot id: H9ENJ3
names: Similarity
messages: Belongs to the TIP41 family.

9544:OPRL1
gene id: 9544:OPRL1
uniprot id: G7N403
uniprot id: H9EUZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

9544:LDLRAD4
gene id: 9544:LDLRAD4
uniprot id: H9YY95
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:GGNBP2
gene id: 9544:GGNBP2
uniprot id: A0A1D5R9L5
uniprot id: A0A5K1VAA7
uniprot id: F6Y1I3
names: Function
messages: May be involved in spermatogenesis.

9544:RTBDN
gene id: 9544:RTBDN
uniprot id: A0A1D5QFI7
names: Similarity
messages: Belongs to the folate receptor family.

9544:A1CF
gene id: 9544:A1CF
uniprot id: F7EC06
names: Subcellular Location Annotation
messages: Cytoplasm

9544:PHKG2
gene id: 9544:PHKG2
uniprot id: H9ETG8
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9544:TSPYL1
gene id: 9544:TSPYL1
uniprot id: H9FZ82
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:LYG1
gene id: 9544:LYG1
uniprot id: G7NAR5
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9544:NRCAM
gene id: 9544:NRCAM
uniprot id: F7HMK0
uniprot id: I2CTL3
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9544:UNC45A
gene id: 9544:UNC45A
uniprot id: H9FX50
names: Subcellular Location Annotation
messages: perinuclear region

9544:EIF1B
gene id: 9544:EIF1B
uniprot id: A0A1D5R466
uniprot id: A0A8J8Y8K6
names: Similarity
messages: Belongs to the SUI1 family.

9544:LOC705310
gene id: 9544:LOC705310
uniprot id: F6PTB1
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

9544:SLC7A7
gene id: 9544:SLC7A7
uniprot id: A0A8J8Y1D8
uniprot id: G7MX23
names: Subcellular Location Annotation
messages: Membrane

9544:PKIA
gene id: 9544:PKIA
uniprot id: A0A8J8XFU5
uniprot id: F6Y6J6
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9544:MAST2
gene id: 9544:MAST2
uniprot id: A0A1D5QG69
uniprot id: F6S9N8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9544:ZNRF4
gene id: 9544:ZNRF4
uniprot id: F7DGP6
names: Subcellular Location Annotation
messages: Membrane

9544:FAM98A
gene id: 9544:FAM98A
uniprot id: F7BNZ9
names: Similarity
messages: Belongs to the FAM98 family.

9544:CALHM6
gene id: 9544:CALHM6
uniprot id: A0A1D5QNX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9544:SPDYA
gene id: 9544:SPDYA
uniprot id: F6Y2M5
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9544:SEC61G
gene id: 9544:SEC61G
uniprot id: F7HPN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:RBX1
gene id: 9544:RBX1
uniprot id: I2CVJ6
names: Similarity
messages: Belongs to the RING-box family.

9544:IMMP2L
gene id: 9544:IMMP2L
uniprot id: F6RN87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

9544:BMP5
gene id: 9544:BMP5
uniprot id: F7H4M7
names: Similarity
messages: Belongs to the TGF-beta family.

9544:TMED6
gene id: 9544:TMED6
uniprot id: F6TW60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:TOR2A
gene id: 9544:TOR2A
uniprot id: A0A8J8XVT6
uniprot id: H9FT45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9544:SOX9
gene id: 9544:SOX9
uniprot id: P61753
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated; acetylation impairs nuclear localization and ability to transactivate expression of target genes. Deacetylated by SIRT1.
messages: Homodimer; homodimerization is required for activity. Interacts (via C-terminus) with ZNF219; forming a complex that binds to the COL2A1 promoter and activates COL2A1 expression (By similarity). Interacts with DDRGK1. Interacts with EP300/p300 (By similarity). Interacts with beta-catenin (CTNNB1); inhibiting CTNNB1 activity by competing with the binding sites of TCF/LEF within CTNNB1 (By similarity).
messages: Nucleus
messages: Phosphorylation at Ser-64 and Ser-211 by PKA increases transcriptional activity and may help delay chondrocyte maturation downstream of PTHLH/PTHrP signaling. Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation. Phosphorylated on tyrosine residues; tyrosine dephosphorylation by PTPN11/SHP2 blocks SOX9 phosphorylation by PKA and subsequent SUMOylation.
messages: Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation. Sumoylation is induced by BMP signaling pathway.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The PQA region (for proline, glutamine and alanine-rich) helps stabilize SOX9 and facilitates transactivation. It lacks intrinsic transactivation capability.
messages: The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.
messages: Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6. Also binds to some promoter regions. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes. Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in…
messages: Ubiquitinated; ubiquitination leads to proteasomal degradation and is negatively regulated by DDRGK1.

9544:NXPE3
gene id: 9544:NXPE3
uniprot id: A0A8J8XBU1
uniprot id: F7EDF4
names: Similarity
messages: Belongs to the NXPE family.

9544:PTP4A3
gene id: 9544:PTP4A3
uniprot id: F6T1U3
uniprot id: G8F1I3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9544:HHEX
gene id: 9544:HHEX
uniprot id: F7HNF7
names: Subcellular Location Annotation
messages: Nucleus

9544:ZNF687
gene id: 9544:ZNF687
uniprot id: A0A8J8YPH2
uniprot id: F6Z211
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9544:LONP1
gene id: 9544:LONP1
uniprot id: F6PU38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer. Organized in a ring with a central cavity. The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber, while the N-terminal domain is arranged as a trimer of dimers. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG.
messages: Mitochondrion matrix

9544:ERN1
gene id: 9544:ERN1
uniprot id: A0A5F8A6W0
uniprot id: F6WBI3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:TRAM2
gene id: 9544:TRAM2
uniprot id: A0A8J8YKH5
uniprot id: G7MPK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9544:RPL26
gene id: 9544:RPL26
uniprot id: A0A8J8YMZ4
uniprot id: F7F4S1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9544:TXLNA
gene id: 9544:TXLNA
uniprot id: A0A8J8XTQ1
uniprot id: G7MI83
names: Similarity
messages: Belongs to the taxilin family.

9544:UNC119
gene id: 9544:UNC119
uniprot id: H9EWD5
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9544:TMEM189
gene id: 9544:TMEM189
uniprot id: H9ES87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9544:LOC695218
gene id: 9544:LOC695218
uniprot id: A0A5K1V1Q4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the small ribosomal subunit.

9544:USP39
gene id: 9544:USP39
uniprot id: H9FNX9
names: Subcellular Location Annotation
messages: Nucleus

9544:SRP54
gene id: 9544:SRP54
uniprot id: A0A1D5Q506
uniprot id: A0A8J8YIP5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

9544:LOC693939
gene id: 9544:LOC693939
uniprot id: A0A5F7ZSU9
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:TMTC1
gene id: 9544:TMTC1
uniprot id: F7AG29
uniprot id: F7AGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9544:RARS
gene id: 9544:RARS
uniprot id: H9FXZ9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:LCN9
gene id: 9544:LCN9
uniprot id: D1YSI6
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9544:XPO5
gene id: 9544:XPO5
uniprot id: I0FTQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9544:POLR2E
gene id: 9544:POLR2E
uniprot id: I2CYA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

9544:CACNG3
gene id: 9544:CACNG3
uniprot id: A0A8J8YK34
uniprot id: F7FN39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9544:SNAP91
gene id: 9544:SNAP91
uniprot id: A0A1D5QM96
uniprot id: F6VKT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9544:S100A4
gene id: 9544:S100A4
uniprot id: A0A8J8YC96
uniprot id: F7GDB8
names: Similarity
messages: Belongs to the S-100 family.

9544:ZC3H14
gene id: 9544:ZC3H14
uniprot id: A0A5F8AR61
uniprot id: F6Q8I2
uniprot id: F6Q8X3
uniprot id: F6Q8Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

9544:KIF20A
gene id: 9544:KIF20A
uniprot id: A0A8J8YRF8
uniprot id: G7MUW1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:DCLRE1B
gene id: 9544:DCLRE1B
uniprot id: F7CS31
uniprot id: G7MIJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9544:CHRNB3
gene id: 9544:CHRNB3
uniprot id: A0A8J8XL00
uniprot id: G7MZ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:EFNB2
gene id: 9544:EFNB2
uniprot id: F7HHG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:QRSL1
gene id: 9544:QRSL1
uniprot id: H9EVL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9544:SLC35A3
gene id: 9544:SLC35A3
uniprot id: H9Z725
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:CNNM2
gene id: 9544:CNNM2
uniprot id: A0A5F8AU49
uniprot id: F6RSX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9544:ECH1
gene id: 9544:ECH1
uniprot id: A0A5F8A1A9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9544:PPIL4
gene id: 9544:PPIL4
uniprot id: A0A8J8XFS4
uniprot id: F6UZE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9544:LAMP1
gene id: 9544:LAMP1
uniprot id: I0FRN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9544:PDE6A
gene id: 9544:PDE6A
uniprot id: F6SMY5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:PLOD2
gene id: 9544:PLOD2
uniprot id: F6WSU7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9544:CLP1
gene id: 9544:CLP1
uniprot id: A0A8J8YRC7
uniprot id: F6QNV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9544:NPY1R
gene id: 9544:NPY1R
uniprot id: A0A8J8XDE1
uniprot id: Q9GK75
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:PRL
gene id: 9544:PRL
uniprot id: P55151
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the somatotropin/prolactin family.
messages: Interacts with PRLR.
messages: Prolactin acts primarily on the mammary gland by promoting lactation.
messages: Secreted

9544:TAF12
gene id: 9544:TAF12
uniprot id: A0A8J8XSE9
uniprot id: F6TWH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9544:ARPC5L
gene id: 9544:ARPC5L
uniprot id: H9G0A9
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9544:SLC11A2
gene id: 9544:SLC11A2
uniprot id: F7HDZ6
uniprot id: H9Z9D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9544:SPRR1B
gene id: 9544:SPRR1B
uniprot id: P35322
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
messages: Cytoplasm
messages: During squamous differentiation of epidermal keratinocytes.

9544:TMSB15A
gene id: 9544:TMSB15A
uniprot id: A0A8J8YHD8
uniprot id: H9FTB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9544:DNPEP
gene id: 9544:DNPEP
uniprot id: H9Z081
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9544:MAL2
gene id: 9544:MAL2
uniprot id: A0A5K1TZG0
names: Subcellular Location Annotation
messages: Membrane

9544:POLR3D
gene id: 9544:POLR3D
uniprot id: G7N0N3
names: Subcellular Location Annotation
messages: Nucleus

9544:PABPC3
gene id: 9544:PABPC3
uniprot id: F7HQN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9544:GALNT11
gene id: 9544:GALNT11
uniprot id: A0A5K1TVC0
uniprot id: F6V8F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:ATG13
gene id: 9544:ATG13
uniprot id: A0A5F7ZJ87
uniprot id: A0A8J8Y0J9
uniprot id: F6T0G8
uniprot id: G7NDH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9544:INSL4
gene id: 9544:INSL4
uniprot id: F7HJH4
names: Subcellular Location Annotation
messages: Secreted

9544:AUP1
gene id: 9544:AUP1
uniprot id: F6UNX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AUP1 family.
messages: Membrane

9544:GNPDA2
gene id: 9544:GNPDA2
uniprot id: A0A1D5Q159
uniprot id: A0A8J8YRF0
uniprot id: H9ENJ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9544:CPLX1
gene id: 9544:CPLX1
uniprot id: A0A8J8YSU7
uniprot id: H9FP10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9544:SEC24B
gene id: 9544:SEC24B
uniprot id: A0A1D5QK29
uniprot id: H9Z4B7
uniprot id: H9Z4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9544:UBE2D3
gene id: 9544:UBE2D3
uniprot id: F6URZ8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:FGFBP1
gene id: 9544:FGFBP1
uniprot id: F7HE10
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9544:CAPN10
gene id: 9544:CAPN10
uniprot id: A0A5K1V6E3
uniprot id: H9FPA8
names: Similarity
messages: Belongs to the peptidase C2 family.

9544:ANKRD13A
gene id: 9544:ANKRD13A
uniprot id: A0A8J8XBQ9
uniprot id: G7N5G0
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9544:PPIP5K2
gene id: 9544:PPIP5K2
uniprot id: A0A1D5Q532
uniprot id: A0A5F7ZHV5
uniprot id: A0A5F8AR12
uniprot id: F7CQD3
uniprot id: F7CQE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9544:PPP1R10
gene id: 9544:PPP1R10
uniprot id: A0A8J8YE11
uniprot id: G7MRF4
uniprot id: Q5TM61
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).
messages: Nucleus
messages: Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9544:SLC25A33
gene id: 9544:SLC25A33
uniprot id: A0A1D5R948
uniprot id: H9G0N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:FAM57B
gene id: 9544:FAM57B
uniprot id: F6V894
names: Subcellular Location Annotation
messages: Membrane

9544:ACMSD
gene id: 9544:ACMSD
uniprot id: A0A8J8XTJ2
uniprot id: F6SQ09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9544:NR0B2
gene id: 9544:NR0B2
uniprot id: A0A8J8XNV1
uniprot id: F6T9I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9544:ANAPC10
gene id: 9544:ANAPC10
uniprot id: F7GPG7
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9544:ARX
gene id: 9544:ARX
uniprot id: A0A5F8ABV8
names: Subcellular Location Annotation
messages: Nucleus

9544:VCP
gene id: 9544:VCP
uniprot id: A0A5F8A4G3
uniprot id: H9EPW4
names: Similarity
messages: Belongs to the AAA ATPase family.

9544:NDE1
gene id: 9544:NDE1
uniprot id: H9YZ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9544:BRI3
gene id: 9544:BRI3
uniprot id: A0A1D5QG70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

9544:SLC31A1
gene id: 9544:SLC31A1
uniprot id: A0A8J8Y820
uniprot id: F6USX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:ATP5IF1
gene id: 9544:ATP5IF1
uniprot id: A0A8J8XI36
uniprot id: F6ZXX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9544:ZDHHC21
gene id: 9544:ZDHHC21
uniprot id: A0A8J8XQX1
uniprot id: G7NFZ6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:PHETA2
gene id: 9544:PHETA2
uniprot id: F7H5I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9544:PGA4
gene id: 9544:PGA4
uniprot id: P11489
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted
messages: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

9544:CCNF
gene id: 9544:CCNF
uniprot id: H9YXV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Nucleus
messages: centriole
messages: perinuclear region

9544:HOXB6
gene id: 9544:HOXB6
uniprot id: A0A8J8XLG6
uniprot id: F7HN78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:GSTM2
gene id: 9544:GSTM2
uniprot id: F7HIX7
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9544:VPS36
gene id: 9544:VPS36
uniprot id: H9FV58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9544:HOXC13
gene id: 9544:HOXC13
uniprot id: A0A5F7Z910
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9544:CDH22
gene id: 9544:CDH22
uniprot id: F7GIE7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:LEAP2
gene id: 9544:LEAP2
uniprot id: Q95M25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9544:DNAH6
gene id: 9544:DNAH6
uniprot id: F6T7U1
names: Similarity
messages: Belongs to the dynein heavy chain family.

9544:MPP2
gene id: 9544:MPP2
uniprot id: H9ERT2
uniprot id: H9H5T9
names: Similarity
messages: Belongs to the MAGUK family.

9544:ABLIM1
gene id: 9544:ABLIM1
uniprot id: F6YH36
names: Subcellular Location Annotation
messages: Cytoplasm

9544:OAF
gene id: 9544:OAF
uniprot id: F6V7A9
names: Similarity
messages: Belongs to the OAF family.

9544:MTHFD1L
gene id: 9544:MTHFD1L
uniprot id: F7G8N5
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9544:TRAPPC1
gene id: 9544:TRAPPC1
uniprot id: A0A8J8YC07
uniprot id: H9ENC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9544:UPF3B
gene id: 9544:UPF3B
uniprot id: F6V224
uniprot id: F6V236
names: Similarity
messages: Belongs to the RENT3 family.

9544:PGLYRP4
gene id: 9544:PGLYRP4
uniprot id: A0A8J8YEV9
uniprot id: F7F8I2
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9544:HJV
gene id: 9544:HJV
uniprot id: F7GPQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9544:LRP6
gene id: 9544:LRP6
uniprot id: A0A8J8XIM2
uniprot id: G7N677
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:PTBP1
gene id: 9544:PTBP1
uniprot id: A0A1D5Q2N4
uniprot id: F7GF18
uniprot id: H9FXJ7
uniprot id: H9FXJ8
names: Subcellular Location Annotation
messages: Nucleus

9544:MGAT5
gene id: 9544:MGAT5
uniprot id: A0A8J8XKS4
uniprot id: G7NB12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9544:ARV1
gene id: 9544:ARV1
uniprot id: A0A5K1UGC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9544:DDRGK1
gene id: 9544:DDRGK1
uniprot id: G7N2U2
names: Similarity
messages: Belongs to the DDRGK1 family.

9544:SKA3
gene id: 9544:SKA3
uniprot id: A0A8J8XDN2
uniprot id: H9Z6C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9544:GPR137C
gene id: 9544:GPR137C
uniprot id: F7DKY4
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9544:CNTN2
gene id: 9544:CNTN2
uniprot id: A0A5K1UJU3
uniprot id: A0A8J8YML4
uniprot id: I2CY45
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9544:PIH1D1
gene id: 9544:PIH1D1
uniprot id: A0A8J8XG84
uniprot id: F7H5R9
names: Similarity
messages: Belongs to the PIH1 family.

9544:CFHR2
gene id: 9544:CFHR2
uniprot id: G7MF05
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TRMT11
gene id: 9544:TRMT11
uniprot id: F6ZLG8
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

9544:LOC696956
gene id: 9544:LOC696956
uniprot id: A0A5F8AMM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:ATXN2L
gene id: 9544:ATXN2L
uniprot id: A0A5F8AD48
uniprot id: F7FFJ8
uniprot id: I2CUK3
names: Similarity
messages: Belongs to the ataxin-2 family.

9544:UNC5D
gene id: 9544:UNC5D
uniprot id: A0A1D5REN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9544:FAM189B
gene id: 9544:FAM189B
uniprot id: A0A1D5Q584
uniprot id: G7MDW8
names: Similarity
messages: Belongs to the ENTREP family.

9544:CYP3A7
gene id: 9544:CYP3A7
uniprot id: B1NL86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:GLT6D1
gene id: 9544:GLT6D1
uniprot id: G7NF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9544:FIGN
gene id: 9544:FIGN
uniprot id: F7HD85
names: Similarity
messages: Belongs to the AAA ATPase family.

9544:LEPROTL1
gene id: 9544:LEPROTL1
uniprot id: H9EQQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9544:HIRA
gene id: 9544:HIRA
uniprot id: A0A5F7ZHE5
uniprot id: H9ZD31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9544:WFDC5
gene id: 9544:WFDC5
uniprot id: A4K2T2
names: Function
names: Subcellular Location Annotation
messages: Putative acid-stable proteinase inhibitor.
messages: Secreted

9544:RPS23
gene id: 9544:RPS23
uniprot id: A0A1D5QU28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Rough endoplasmic reticulum

9544:ACSS3
gene id: 9544:ACSS3
uniprot id: F6T734
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:OVOL2
gene id: 9544:OVOL2
uniprot id: I2CYC8
names: Subcellular Location Annotation
messages: Nucleus

9544:RNF157
gene id: 9544:RNF157
uniprot id: H9FPK0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9544:PPP4R3C
gene id: 9544:PPP4R3C
uniprot id: F6W1B0
names: Similarity
messages: Belongs to the SMEK family.

9544:RBM47
gene id: 9544:RBM47
uniprot id: A0A5F8AS32
uniprot id: A0A8J8Y7I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Cytoplasm
messages: Nucleus

9544:AGMAT
gene id: 9544:AGMAT
uniprot id: H9H2W0
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

9544:TXLNG
gene id: 9544:TXLNG
uniprot id: A0A1D5RC87
uniprot id: A0A8J8Y1L7
uniprot id: F7GH86
names: Similarity
messages: Belongs to the taxilin family.

9544:BTG2
gene id: 9544:BTG2
uniprot id: A0A8J8XKW8
uniprot id: F7H251
names: Similarity
messages: Belongs to the BTG family.

9544:FAM13A
gene id: 9544:FAM13A
uniprot id: A0A1D5QKZ7
names: Similarity
messages: Belongs to the FAM13 family.

9544:VIL1
gene id: 9544:VIL1
uniprot id: A0A8J8Y2B9
uniprot id: F7CQ79
names: Similarity
messages: Belongs to the villin/gelsolin family.

9544:PCBD1
gene id: 9544:PCBD1
uniprot id: F7F694
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9544:ANO3
gene id: 9544:ANO3
uniprot id: A0A8J8XZN3
uniprot id: G7NDQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9544:AACS
gene id: 9544:AACS
uniprot id: I0FH72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
messages: cytosol

9544:SCML2
gene id: 9544:SCML2
uniprot id: A0A8J8YMI1
uniprot id: G7NSC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9544:WASHC3
gene id: 9544:WASHC3
uniprot id: A0A1D5R8K9
uniprot id: A0A1D5RKQ7
uniprot id: H9FV54
names: Similarity
messages: Belongs to the CCDC53 family.

9544:DYNLRB2
gene id: 9544:DYNLRB2
uniprot id: F7FWX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9544:PENK
gene id: 9544:PENK
uniprot id: A0A8J8Y287
uniprot id: G7MZE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9544:KRT73
gene id: 9544:KRT73
uniprot id: F7AEN7
names: Similarity
messages: Belongs to the intermediate filament family.

9544:LCORL
gene id: 9544:LCORL
uniprot id: F7EPM8
names: Subcellular Location Annotation
messages: Nucleus

9544:GTF2E1
gene id: 9544:GTF2E1
uniprot id: F7HTP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIE alpha subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

9544:CTSV
gene id: 9544:CTSV
uniprot id: G7NF51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9544:MTMR3
gene id: 9544:MTMR3
uniprot id: F6Z1N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9544:MAPRE3
gene id: 9544:MAPRE3
uniprot id: A0A5F7ZS41
uniprot id: A0A8J8YS23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9544:C13H2orf68
gene id: 9544:C13H2orf68
uniprot id: A0A8J8YBY0
uniprot id: G7NAJ1
names: Similarity
messages: Belongs to the UPF0561 family.

9544:LARS2
gene id: 9544:LARS2
uniprot id: A0A8J8Y979
uniprot id: G7MIU9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:PCNA
gene id: 9544:PCNA
uniprot id: F6ZD63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9544:GPRASP2
gene id: 9544:GPRASP2
uniprot id: F6RAD9
uniprot id: G8F1A2
names: Similarity
messages: Belongs to the GPRASP family.

9544:PTP4A2
gene id: 9544:PTP4A2
uniprot id: H9EN41
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9544:SRPX
gene id: 9544:SRPX
uniprot id: G7NT00
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:LOC698056
gene id: 9544:LOC698056
uniprot id: A0A8J8Y577
uniprot id: F7B9G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

9544:RDH5
gene id: 9544:RDH5
uniprot id: A0A8J8YR78
uniprot id: G7N797
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:GIMAP5
gene id: 9544:GIMAP5
uniprot id: F7HGI6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9544:MSX2
gene id: 9544:MSX2
uniprot id: I0FIU9
names: Subcellular Location Annotation
messages: Nucleus

9544:PLCB1
gene id: 9544:PLCB1
uniprot id: F6R8R8
uniprot id: F6ZKL2
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9544:TP53RK
gene id: 9544:TP53RK
uniprot id: H9EW85
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

9544:CYP2F1
gene id: 9544:CYP2F1
uniprot id: Q58HA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane
messages: Microsome membrane

9544:DDX43
gene id: 9544:DDX43
uniprot id: A0A8J8XP20
uniprot id: F7B8M1
names: Similarity
messages: Belongs to the DEAD box helicase family.

9544:NLGN1
gene id: 9544:NLGN1
uniprot id: A0A8J8YL69
uniprot id: F6RUI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9544:KCNA1
gene id: 9544:KCNA1
uniprot id: A0A8J8YKG6
uniprot id: F7DS72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:ACER3
gene id: 9544:ACER3
uniprot id: F7EYF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9544:YPEL5
gene id: 9544:YPEL5
uniprot id: A0A8J8Y037
uniprot id: F6Y2U2
names: Similarity
messages: Belongs to the yippee family.

9544:PSEN1
gene id: 9544:PSEN1
uniprot id: A0A5K1VUH6
uniprot id: F7AGU8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9544:IARS
gene id: 9544:IARS
uniprot id: H9Z8F3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9544:MEX3A
gene id: 9544:MEX3A
uniprot id: A0A5F7ZFD5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:LAPTM5
gene id: 9544:LAPTM5
uniprot id: F7DW52
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9544:GALNT4
gene id: 9544:GALNT4
uniprot id: H9G186
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:LOC693464
gene id: 9544:LOC693464
uniprot id: A0A8J8Y6A8
uniprot id: F7FJE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9544:CLCN5
gene id: 9544:CLCN5
uniprot id: F6V6U2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:SET
gene id: 9544:SET
uniprot id: H9YY26
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:STAC2
gene id: 9544:STAC2
uniprot id: F6Z114
names: Subcellular Location Annotation
messages: sarcolemma

9544:INPP1
gene id: 9544:INPP1
uniprot id: A0A5K1UJ25
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9544:FCHO1
gene id: 9544:FCHO1
uniprot id: A0A8J8YJ47
uniprot id: G7NMS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

9544:NATD1
gene id: 9544:NATD1
uniprot id: A0A5F8AQE2
names: Similarity
messages: Belongs to the NATD1 family.

9544:TUB
gene id: 9544:TUB
uniprot id: F6ZVE9
uniprot id: H9FZ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9544:GANC
gene id: 9544:GANC
uniprot id: A0A8J8YQF3
uniprot id: H9EVN5
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9544:SEC23A
gene id: 9544:SEC23A
uniprot id: A0A8J8YFE4
uniprot id: G7MXN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9544:LYPLA1
gene id: 9544:LYPLA1
uniprot id: F6SPC5
uniprot id: F6Z819
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9544:CAPRIN2
gene id: 9544:CAPRIN2
uniprot id: A0A5F8ASA5
names: Similarity
messages: Belongs to the caprin family.

9544:ARSG
gene id: 9544:ARSG
uniprot id: A0A5F7ZR14
names: Similarity
messages: Belongs to the sulfatase family.

9544:WNT7A
gene id: 9544:WNT7A
uniprot id: F7HEW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:MDGA1
gene id: 9544:MDGA1
uniprot id: F6S264
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:HVCN1
gene id: 9544:HVCN1
uniprot id: F6TBN6
uniprot id: F6TBP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9544:TMEM45A
gene id: 9544:TMEM45A
uniprot id: A0A8J8YIN8
uniprot id: F6YZ93
uniprot id: G7MK17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9544:RPL32
gene id: 9544:RPL32
uniprot id: F7B979
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9544:CXCL10
gene id: 9544:CXCL10
uniprot id: Q8MIZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity).
messages: Secreted

9544:CHSY1
gene id: 9544:CHSY1
uniprot id: F7H7B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9544:DNMT3L
gene id: 9544:DNMT3L
uniprot id: A0A8J8XEH8
uniprot id: F7BC47
names: Subcellular Location Annotation
messages: Nucleus

9544:SMAD9
gene id: 9544:SMAD9
uniprot id: F6YG89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9544:DNASE1L1
gene id: 9544:DNASE1L1
uniprot id: A0A8J8YF84
uniprot id: F7FYN3
names: Similarity
messages: Belongs to the DNase I family.

9544:DDX27
gene id: 9544:DDX27
uniprot id: G7N4K8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9544:SNX14
gene id: 9544:SNX14
uniprot id: F7GA99
uniprot id: H9YYU0
uniprot id: H9ZBK3
names: Similarity
messages: Belongs to the sorting nexin family.

9544:AP1M1
gene id: 9544:AP1M1
uniprot id: F7AVN6
uniprot id: I2CUA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9544:TRIM27
gene id: 9544:TRIM27
uniprot id: A0A1D5QSL3
uniprot id: A0A8J8XF49
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:LGR4
gene id: 9544:LGR4
uniprot id: F6QK18
names: Subcellular Location Annotation
messages: Membrane

9544:ABITRAM
gene id: 9544:ABITRAM
uniprot id: F6Z045
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9544:RICTOR
gene id: 9544:RICTOR
uniprot id: F7GUW7
names: Similarity
messages: Belongs to the RICTOR family.

9544:SIX6
gene id: 9544:SIX6
uniprot id: A0A8J8YQF4
uniprot id: G7MY76
names: Subcellular Location Annotation
messages: Nucleus

9544:RELL1
gene id: 9544:RELL1
uniprot id: F6W385
names: Similarity
messages: Belongs to the RELT family.

9544:AMPD1
gene id: 9544:AMPD1
uniprot id: F6VAM7
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9544:ACTR3B
gene id: 9544:ACTR3B
uniprot id: A0A1D5RDF9
uniprot id: F7H2T8
names: Similarity
messages: Belongs to the actin family.

9544:PPP6C
gene id: 9544:PPP6C
uniprot id: A0A1D5QED9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9544:ATG2B
gene id: 9544:ATG2B
uniprot id: F6PWS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9544:STAM
gene id: 9544:STAM
uniprot id: G7N1N9
uniprot id: H9ESU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9544:LPCAT1
gene id: 9544:LPCAT1
uniprot id: H9ZDP6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9544:RCL1
gene id: 9544:RCL1
uniprot id: A0A1D5Q4K8
uniprot id: F7HHJ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

9544:CPLX3
gene id: 9544:CPLX3
uniprot id: A0A8J8YGL1
uniprot id: G7MY72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9544:OR5M9
gene id: 9544:OR5M9
uniprot id: A0A1D5Q7Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:LOC698354
gene id: 9544:LOC698354
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:NETO1
gene id: 9544:NETO1
uniprot id: A0A8J8XDT8
uniprot id: F7BZP4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:AP3M1
gene id: 9544:AP3M1
uniprot id: A0A1D5QZK2
uniprot id: A0A8J8Y6M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9544:OR10P1
gene id: 9544:OR10P1
uniprot id: G7N793
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CCDC47
gene id: 9544:CCDC47
uniprot id: A0A8J8YEN7
uniprot id: F7AHG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC47 family.
messages: Rough endoplasmic reticulum membrane

9544:ASAH2
gene id: 9544:ASAH2
uniprot id: A0A8J8YN52
uniprot id: F7ESF6
names: Similarity
messages: Belongs to the neutral ceramidase family.

9544:AMIGO2
gene id: 9544:AMIGO2
uniprot id: F7FJR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9544:MCTS1
gene id: 9544:MCTS1
uniprot id: A0A1D5QIT9
uniprot id: H9EQ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9544:CNOT11
gene id: 9544:CNOT11
uniprot id: A0A8J8XIY9
uniprot id: F6RQB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

9544:OR5AP2
gene id: 9544:OR5AP2
uniprot id: F6WZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:GPM6B
gene id: 9544:GPM6B
uniprot id: A0A1D5RHL7
uniprot id: A0A5F8ARV6
uniprot id: A0A8J8XQP0
uniprot id: F6RG95
uniprot id: G7MKT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9544:LYAR
gene id: 9544:LYAR
uniprot id: F7DZD6
names: Subcellular Location Annotation
messages: Cytoplasm

9544:DNM2
gene id: 9544:DNM2
uniprot id: F7FL98
uniprot id: F7FLA4
uniprot id: I2CY05
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9544:TMEM208
gene id: 9544:TMEM208
uniprot id: F6UJ58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9544:CDKN1A
gene id: 9544:CDKN1A
uniprot id: A0A8J8XZT2
uniprot id: F7EEK4
names: Similarity
messages: Belongs to the CDI family.

9544:F10
gene id: 9544:F10
uniprot id: A0N065
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:PYCR1
gene id: 9544:PYCR1
uniprot id: A0A8J8YIN6
uniprot id: F6TMV9
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9544:NEURL2
gene id: 9544:NEURL2
uniprot id: A0A8J8XDZ4
uniprot id: F6RBR9
names: Subcellular Location Annotation
messages: Cytoplasm

9544:GNS
gene id: 9544:GNS
uniprot id: A0A1D5QTV5
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9544:ERCC3
gene id: 9544:ERCC3
uniprot id: H9FR52
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9544:EML5
gene id: 9544:EML5
uniprot id: F6Q7T2
uniprot id: F6RYA9
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

9544:LOC697790
gene id: 9544:LOC697790
uniprot id: I2CT89
names: Similarity
messages: Belongs to the ATG8 family.

9544:PFDN1
gene id: 9544:PFDN1
uniprot id: A0A8J8Y8M9
uniprot id: F7FK57
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9544:MRPS18A
gene id: 9544:MRPS18A
uniprot id: H9FWJ2
names: Subcellular Location Annotation
messages: Mitochondrion

9544:NAGK
gene id: 9544:NAGK
uniprot id: A0A8J8XGM2
uniprot id: F6WHT9
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9544:GLRA4
gene id: 9544:GLRA4
uniprot id: F7B6A7
uniprot id: F7E7S2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9544:DUSP10
gene id: 9544:DUSP10
uniprot id: A0A8J8Y948
uniprot id: F7FRL4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9544:PPFIA4
gene id: 9544:PPFIA4
uniprot id: A0A1D5Q7H8
uniprot id: A0A1D5QW96
uniprot id: F7HM51
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9544:EHD1
gene id: 9544:EHD1
uniprot id: A0A8J8XE44
uniprot id: F6XYM2
uniprot id: G7NCH3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9544:LOC709417
gene id: 9544:LOC709417
uniprot id: A0A5K1VTR3
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9544:DEFB118
gene id: 9544:DEFB118
uniprot id: G7N562
uniprot id: Q95LI0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: High-level and epididymis-specific expression. Most abundant in the epithelium of the caput and is also present in the lumen and bound to sperm.
messages: Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis (By similarity). Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes (By similarity). Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface (By similarity). Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization (By similarity). May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms (By similarity).
messages: Secreted
messages: The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for antimicrobial activity.

9544:STAM2
gene id: 9544:STAM2
uniprot id: F7GA07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9544:SUMF1
gene id: 9544:SUMF1
uniprot id: A0A5K1VGD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9544:VPS16
gene id: 9544:VPS16
uniprot id: A0A8J8XQN3
uniprot id: G7N2T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9544:NHEJ1
gene id: 9544:NHEJ1
uniprot id: E5FGE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

9544:GNB5
gene id: 9544:GNB5
uniprot id: H9FNX2
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9544:GMDS
gene id: 9544:GMDS
uniprot id: F7GZ39
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9544:GALE
gene id: 9544:GALE
uniprot id: A0A8J8YKJ0
uniprot id: H9EVN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9544:SNRPA1
gene id: 9544:SNRPA1
uniprot id: A0A8J8YEN2
uniprot id: G7MWB8
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9544:LHFPL6
gene id: 9544:LHFPL6
uniprot id: F7GID1
names: Subcellular Location Annotation
messages: Membrane

9544:TMTC2
gene id: 9544:TMTC2
uniprot id: H9FQL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9544:COQ10A
gene id: 9544:COQ10A
uniprot id: H9EST6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9544:ARSJ
gene id: 9544:ARSJ
uniprot id: F7HDJ5
uniprot id: G7MRU4
names: Similarity
messages: Belongs to the sulfatase family.

9544:NCK2
gene id: 9544:NCK2
uniprot id: A0A5F8AJZ6
uniprot id: A0A8J8XPM7
uniprot id: F7D094
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9544:CNR2
gene id: 9544:CNR2
uniprot id: F6Z3G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:MINDY3
gene id: 9544:MINDY3
uniprot id: A0A5F7ZVR7
uniprot id: A0A8J8XAR7
uniprot id: F7GVK3
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9544:LOC711421
gene id: 9544:LOC711421
uniprot id: A0A8J8Y6A8
uniprot id: F7FJE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9544:GATC
gene id: 9544:GATC
uniprot id: A0A8J8Y1Q7
uniprot id: G7N5Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9544:LOC716444
gene id: 9544:LOC716444
uniprot id: G7NEM2
names: Subcellular Location Annotation
messages: Membrane

9544:LOC693330
gene id: 9544:LOC693330
uniprot id: F7CMX7
names: Similarity
messages: Belongs to the GAGE family.

9544:NR1D2
gene id: 9544:NR1D2
uniprot id: H9EUD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9544:MRPS18C
gene id: 9544:MRPS18C
uniprot id: A0A5S6R9X2
uniprot id: G8F181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9544:GSKIP
gene id: 9544:GSKIP
uniprot id: A0A8J8YR43
uniprot id: F7FES1
names: Similarity
messages: Belongs to the GSKIP family.

9544:CPSF7
gene id: 9544:CPSF7
uniprot id: A0A1D5QK95
uniprot id: F7DUH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9544:TENT5D
gene id: 9544:TENT5D
uniprot id: A0A8J8Y0V1
uniprot id: F6UZX0
names: Similarity
messages: Belongs to the TENT family.

9544:RNF31
gene id: 9544:RNF31
uniprot id: H9EUS9
names: Similarity
messages: Belongs to the RBR family.

9544:RTN4
gene id: 9544:RTN4
uniprot id: H9YXD4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ETNPPL
gene id: 9544:ETNPPL
uniprot id: G7MTL7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9544:PANX1
gene id: 9544:PANX1
uniprot id: A0A5F8A6N2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9544:TTC21B
gene id: 9544:TTC21B
uniprot id: A0A5F8AM29
names: Similarity
messages: Belongs to the TTC21 family.

9544:MMP16
gene id: 9544:MMP16
uniprot id: F6XP71
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9544:CCDC90B
gene id: 9544:CCDC90B
uniprot id: I2CW50
names: Similarity
messages: Belongs to the CCDC90 family.

9544:FAM18B1
gene id: 9544:FAM18B1
uniprot id: G7NN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9544:GLI1
gene id: 9544:GLI1
uniprot id: I0FMN4
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9544:PPP1R14C
gene id: 9544:PPP1R14C
uniprot id: F7H817
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Inhibitor of PPP1CA.
messages: Membrane

9544:TNFSF4
gene id: 9544:TNFSF4
uniprot id: A0A1D5QQH7
uniprot id: A0A8J8YKS3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9544:CCL13
gene id: 9544:CCL13
uniprot id: A0A8J8YBV4
uniprot id: F6Y1J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9544:SKAP2
gene id: 9544:SKAP2
uniprot id: A0A1D5R563
names: Similarity
messages: Belongs to the SKAP family.

9544:CPNE3
gene id: 9544:CPNE3
uniprot id: H9ESU0
names: Similarity
messages: Belongs to the copine family.

9544:ARF5
gene id: 9544:ARF5
uniprot id: H9ENQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9544:LOC695066
gene id: 9544:LOC695066
uniprot id: G7NFB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:SLC2A4
gene id: 9544:SLC2A4
uniprot id: G7NIE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9544:UFM1
gene id: 9544:UFM1
uniprot id: F6VE95
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9544:DOLK
gene id: 9544:DOLK
uniprot id: A0A8J8XLE6
uniprot id: F7HSL4
names: Similarity
messages: Belongs to the polyprenol kinase family.

9544:CAMK2D
gene id: 9544:CAMK2D
uniprot id: A0A1D5QEN3
uniprot id: F6UGY3
uniprot id: F7H4F4
uniprot id: H9G098
uniprot id: H9ZE08
uniprot id: H9ZE10
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9544:KRT8
gene id: 9544:KRT8
uniprot id: F6U9A3
names: Similarity
messages: Belongs to the intermediate filament family.

9544:CEBPD
gene id: 9544:CEBPD
uniprot id: F6Z8Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9544:LMNB2
gene id: 9544:LMNB2
uniprot id: F6R7X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9544:MRPL44
gene id: 9544:MRPL44
uniprot id: F7HSW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

9544:AVPI1
gene id: 9544:AVPI1
uniprot id: H9EXG8
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9544:GJA10
gene id: 9544:GJA10
uniprot id: G7MPX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:NFIA
gene id: 9544:NFIA
uniprot id: F6SYH5
uniprot id: F6SYI5
uniprot id: F6WYT7
uniprot id: I0FKB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9544:CLIP1
gene id: 9544:CLIP1
uniprot id: A0A1D5QUX4
uniprot id: A0A5F8AM53
uniprot id: F6T4A4
names: Subcellular Location Annotation
messages: cytoskeleton

9544:GOLGA5
gene id: 9544:GOLGA5
uniprot id: H9ZG37
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

9544:FAM83B
gene id: 9544:FAM83B
uniprot id: F6Q2E7
names: Similarity
messages: Belongs to the FAM83 family.

9544:PEX5L
gene id: 9544:PEX5L
uniprot id: A0A1D5R9N3
uniprot id: A0A8J8Y7Y6
uniprot id: F7EMK9
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9544:NUP35
gene id: 9544:NUP35
uniprot id: A0A1D5R653
uniprot id: F6XL37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9544:FAM221A
gene id: 9544:FAM221A
uniprot id: F7EF41
names: Similarity
messages: Belongs to the FAM221 family.

9544:PDHX
gene id: 9544:PDHX
uniprot id: G7NDL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9544:PEX13
gene id: 9544:PEX13
uniprot id: A0A8J8YRF9
uniprot id: H9ER79
names: Similarity
messages: Belongs to the peroxin-13 family.

9544:MINPP1
gene id: 9544:MINPP1
uniprot id: F6SM55
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

9544:SPI1
gene id: 9544:SPI1
uniprot id: F6T6B4
uniprot id: H9EPT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:CASP9
gene id: 9544:CASP9
uniprot id: I0FVL9
names: Similarity
messages: Belongs to the peptidase C14A family.

9544:CAPN9
gene id: 9544:CAPN9
uniprot id: F6TLE9
names: Similarity
messages: Belongs to the peptidase C2 family.

9544:PPP1R9A
gene id: 9544:PPP1R9A
uniprot id: A0A1D5QXY8
uniprot id: F7H7K4
uniprot id: F7HLC5
names: Subcellular Location Annotation
messages: cytoskeleton

9544:GDI1
gene id: 9544:GDI1
uniprot id: F7FLQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9544:NXN
gene id: 9544:NXN
uniprot id: F6VRC1
names: Similarity
messages: Belongs to the nucleoredoxin family.

9544:TMEM242
gene id: 9544:TMEM242
uniprot id: A0A8J8XEN4
uniprot id: F7HL96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9544:ROCK1
gene id: 9544:ROCK1
uniprot id: H9EPT5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

9544:DNAJB12
gene id: 9544:DNAJB12
uniprot id: G7N273
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:RPRD1B
gene id: 9544:RPRD1B
uniprot id: A0A8J8Y5V0
uniprot id: G7N4V9
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9544:PTPN6
gene id: 9544:PTPN6
uniprot id: A0A5K1UTD3
uniprot id: I0FMS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9544:B3GAT1
gene id: 9544:B3GAT1
uniprot id: A0A1D5QFY7
uniprot id: A0A5F8AIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:MAML3
gene id: 9544:MAML3
uniprot id: F6RJ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9544:PHOX2B
gene id: 9544:PHOX2B
uniprot id: A0A5F7ZPS3
names: Subcellular Location Annotation
messages: Nucleus

9544:HMGN1
gene id: 9544:HMGN1
uniprot id: A0A1D5RJ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9544:RPLP0
gene id: 9544:RPLP0
uniprot id: F7HRN7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9544:RASGRP3
gene id: 9544:RASGRP3
uniprot id: H9EU58
names: Similarity
messages: Belongs to the RASGRP family.

9544:UBE3A
gene id: 9544:UBE3A
uniprot id: H9EMG4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9544:CCL27
gene id: 9544:CCL27
uniprot id: Q8HYP2
names: Subcellular Location Annotation
messages: Secreted

9544:TAF4B
gene id: 9544:TAF4B
uniprot id: F7FQ60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

9544:NEK9
gene id: 9544:NEK9
uniprot id: F6U7G5
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9544:SLC27A1
gene id: 9544:SLC27A1
uniprot id: A0A8J8XYT6
uniprot id: G7NMS0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:CLDND2
gene id: 9544:CLDND2
uniprot id: A0A5F7ZNN9
uniprot id: A0A5F8A8S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9544:BMP1
gene id: 9544:BMP1
uniprot id: F7HAA9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:PIWIL2
gene id: 9544:PIWIL2
uniprot id: E1AWN8
names: Similarity
messages: Belongs to the argonaute family.

9544:GDPGP1
gene id: 9544:GDPGP1
uniprot id: F7FPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9544:LOC695323
gene id: 9544:LOC695323
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:AP2M1
gene id: 9544:AP2M1
uniprot id: H9FPP5
uniprot id: H9Z538
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9544:PHYKPL
gene id: 9544:PHYKPL
uniprot id: H9EWC7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9544:SLC4A3
gene id: 9544:SLC4A3
uniprot id: I2CV39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

9544:SLC17A7
gene id: 9544:SLC17A7
uniprot id: F6W612
names: Subcellular Location Annotation
messages: Membrane

9544:WSCD2
gene id: 9544:WSCD2
uniprot id: F6R2N2
names: Function
names: Similarity
messages: Belongs to the WSCD family.
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9544:ATP8A1
gene id: 9544:ATP8A1
uniprot id: F7F3Y6
uniprot id: H9EM46
uniprot id: H9FNN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9544:PDSS2
gene id: 9544:PDSS2
uniprot id: A0A8J8Y853
uniprot id: G7MQ10
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9544:KCNC2
gene id: 9544:KCNC2
uniprot id: F7BL49
uniprot id: F7BL65
uniprot id: F7EIZ1
uniprot id: H9FU55
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:INTS11
gene id: 9544:INTS11
uniprot id: G7MG87
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9544:KRT34
gene id: 9544:KRT34
uniprot id: A0A5K1VLD6
names: Similarity
messages: Belongs to the intermediate filament family.

9544:REEP3
gene id: 9544:REEP3
uniprot id: H9Z1D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9544:CRPPA
gene id: 9544:CRPPA
uniprot id: A0A5F8ART5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Homodimer.
messages: cytosol

9544:SFXN1
gene id: 9544:SFXN1
uniprot id: A0A5F7ZTM7
uniprot id: F7DBC0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9544:ADGRG2
gene id: 9544:ADGRG2
uniprot id: A0A8J8Y8Z3
uniprot id: F7AYM6
names: Subcellular Location Annotation
messages: Membrane

9544:STRIP1
gene id: 9544:STRIP1
uniprot id: G7MIF2
names: Similarity
messages: Belongs to the STRIP family.

9544:ITPRIPL1
gene id: 9544:ITPRIPL1
uniprot id: A0A5K1TYG5
uniprot id: F7A9W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9544:GPBP1
gene id: 9544:GPBP1
uniprot id: F7FZ98
uniprot id: F7H9N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9544:CCT3
gene id: 9544:CCT3
uniprot id: A0A8J8YP63
uniprot id: G7MDZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9544:AKT1
gene id: 9544:AKT1
uniprot id: A0A8J8XKC5
uniprot id: G7MWI7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9544:KCNAB1
gene id: 9544:KCNAB1
uniprot id: F6UT99
uniprot id: F7B6M9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Monomer.

9544:TM9SF3
gene id: 9544:TM9SF3
uniprot id: F7GMS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9544:LOC695959
gene id: 9544:LOC695959
uniprot id: F6RGH6
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9544:PPME1
gene id: 9544:PPME1
uniprot id: A0A1D5RGC1
uniprot id: H9EPW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

9544:UBE2E3
gene id: 9544:UBE2E3
uniprot id: A0A1D5QJN8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:CLIC2
gene id: 9544:CLIC2
uniprot id: A0A8J8XTL5
uniprot id: F6YUR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

9544:LOC704498
gene id: 9544:LOC704498
uniprot id: G7MJZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Part of the 60S ribosomal subunit.

9544:MFAP5
gene id: 9544:MFAP5
uniprot id: F7FYE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

9544:CUTC
gene id: 9544:CUTC
uniprot id: H9EMJ1
names: Similarity
messages: Belongs to the CutC family.

9544:TMEM54
gene id: 9544:TMEM54
uniprot id: F7HU94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9544:PTPRS
gene id: 9544:PTPRS
uniprot id: F7HG94
uniprot id: F7HG97
uniprot id: H9FXV0
uniprot id: I2CY17
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

9544:LMOD1
gene id: 9544:LMOD1
uniprot id: I0FQL5
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9544:SNX33
gene id: 9544:SNX33
uniprot id: F7GL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9544:HAT1
gene id: 9544:HAT1
uniprot id: A0A8J8XV08
uniprot id: F7F2T1
uniprot id: G7N8B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9544:RBM5
gene id: 9544:RBM5
uniprot id: I0FNA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9544:CLIC4
gene id: 9544:CLIC4
uniprot id: F6PP70
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9544:PTGS2
gene id: 9544:PTGS2
uniprot id: G7MF20
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:HTR3B
gene id: 9544:HTR3B
uniprot id: A0A8J8XNB9
uniprot id: F7ESG7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:GRIA1
gene id: 9544:GRIA1
uniprot id: A0A8J8YG09
uniprot id: G7MVP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9544:L3MBTL3
gene id: 9544:L3MBTL3
uniprot id: H9ZEE6
uniprot id: I0FJ08
names: Subcellular Location Annotation
messages: Nucleus

9544:NPBWR1
gene id: 9544:NPBWR1
uniprot id: F7H731
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:TAF10
gene id: 9544:TAF10
uniprot id: F7C2U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

9544:NECTIN4
gene id: 9544:NECTIN4
uniprot id: A0A5F7ZXJ3
uniprot id: A0A5F8A3I3
names: Similarity
messages: Belongs to the nectin family.

9544:PDC
gene id: 9544:PDC
uniprot id: A0A8J8XQT0
uniprot id: F7EQ61
names: Similarity
messages: Belongs to the phosducin family.

9544:FTH1
gene id: 9544:FTH1
uniprot id: F7F2L7
uniprot id: Q9GMG9
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9544:MX1
gene id: 9544:MX1
uniprot id: A1E2I4
uniprot id: H9FUQ9
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By type I and type III interferons.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).
messages: ISGylated.
messages: Interferon-induced dynamin-like GTPase with antiviral activity.
messages: The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
messages: The middle domain mediates self-assembly and oligomerization.
messages: perinuclear region

9544:EMC2
gene id: 9544:EMC2
uniprot id: I0FH38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

9544:SRP72
gene id: 9544:SRP72
uniprot id: H9FYW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

9544:FIGNL1
gene id: 9544:FIGNL1
uniprot id: G7MLA9
names: Similarity
messages: Belongs to the AAA ATPase family.

9544:C1GALT1
gene id: 9544:C1GALT1
uniprot id: A0A5F7ZS52
uniprot id: F7GRL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Membrane

9544:DLGAP5
gene id: 9544:DLGAP5
uniprot id: H9ZFW5
names: Similarity
messages: Belongs to the SAPAP family.

9544:GPC2
gene id: 9544:GPC2
uniprot id: A0A5F7ZVR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9544:HSDL1
gene id: 9544:HSDL1
uniprot id: G7NPE7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:PRPSAP1
gene id: 9544:PRPSAP1
uniprot id: A0A8J8XIX7
uniprot id: G7NGX7
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9544:NOC4L
gene id: 9544:NOC4L
uniprot id: H9EX29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane

9544:IGF2BP3
gene id: 9544:IGF2BP3
uniprot id: F6WAQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9544:SNX32
gene id: 9544:SNX32
uniprot id: A0A8J8Y3X0
uniprot id: G7NC86
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9544:KCTD18
gene id: 9544:KCTD18
uniprot id: H9FPY4
names: Subcellular Location Annotation
messages: Cell membrane

9544:CDH8
gene id: 9544:CDH8
uniprot id: A0A8J8Y887
uniprot id: H9FND6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:LOC699053
gene id: 9544:LOC699053
uniprot id: F7F2L7
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9544:NDUFB8
gene id: 9544:NDUFB8
uniprot id: F7H444
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:MAST1
gene id: 9544:MAST1
uniprot id: A0A1D5QYU4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9544:RHAG
gene id: 9544:RHAG
uniprot id: Q9GMG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9544:CNIH2
gene id: 9544:CNIH2
uniprot id: H9FSE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9544:CSF3R
gene id: 9544:CSF3R
uniprot id: F6TU14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9544:EBP
gene id: 9544:EBP
uniprot id: A0A1D5QI42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CITED1
gene id: 9544:CITED1
uniprot id: G7NS41
uniprot id: I0FRV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9544:SCFD1
gene id: 9544:SCFD1
uniprot id: I0FQ93
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9544:PDE6H
gene id: 9544:PDE6H
uniprot id: A0A8J8XUE8
uniprot id: F6SQF2
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9544:SAMM50
gene id: 9544:SAMM50
uniprot id: A0A8J8Y550
uniprot id: I0FQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9544:ZBED1
gene id: 9544:ZBED1
uniprot id: A0A8J8Y5E6
uniprot id: F6QDB5
names: Subcellular Location Annotation
messages: Nucleus

9544:LOC693706
gene id: 9544:LOC693706
uniprot id: A0A5F7ZTX5
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

9544:IAH1
gene id: 9544:IAH1
uniprot id: F7EV90
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9544:GABRA4
gene id: 9544:GABRA4
uniprot id: A0A8J8XF17
uniprot id: F6YLN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:EPHB3
gene id: 9544:EPHB3
uniprot id: F7ELA0
names: Subcellular Location Annotation
messages: Membrane

9544:CLPS
gene id: 9544:CLPS
uniprot id: F6SG32
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9544:RNF175
gene id: 9544:RNF175
uniprot id: F7C8F7
names: Subcellular Location Annotation
messages: Membrane

9544:SPATA20
gene id: 9544:SPATA20
uniprot id: A0A5F8ADW9
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

9544:MAPRE1
gene id: 9544:MAPRE1
uniprot id: A0A8J8XSI8
uniprot id: G7N533
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9544:MADD
gene id: 9544:MADD
uniprot id: I0FVY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9544:ZKSCAN3
gene id: 9544:ZKSCAN3
uniprot id: A0A5F7ZY50
names: Subcellular Location Annotation
messages: Nucleus

9544:ATP5PB
gene id: 9544:ATP5PB
uniprot id: H9FVK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9544:LOC710545
gene id: 9544:LOC710545
uniprot id: A7E3J4
names: Subcellular Location Annotation
messages: Nucleus

9544:TMEM8B
gene id: 9544:TMEM8B
uniprot id: A0A5F7Z7T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9544:SBF2
gene id: 9544:SBF2
uniprot id: A0A5K1V3F8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9544:ZNF174
gene id: 9544:ZNF174
uniprot id: A0A8J8XU46
uniprot id: F6SZV8
names: Subcellular Location Annotation
messages: Nucleus

9544:RIPOR1
gene id: 9544:RIPOR1
uniprot id: F7H5B3
names: Similarity
messages: Belongs to the RIPOR family.

9544:TP53I11
gene id: 9544:TP53I11
uniprot id: A0A5K1V206
names: Subcellular Location Annotation
messages: Membrane

9544:SUPT5H
gene id: 9544:SUPT5H
uniprot id: F6XPK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9544:SMAD5
gene id: 9544:SMAD5
uniprot id: F6YMS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9544:GJA8
gene id: 9544:GJA8
uniprot id: A0A8J8XMQ3
uniprot id: F7D0V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:LOC696144
gene id: 9544:LOC696144
uniprot id: A0A8J8XHG3
uniprot id: F6ZG64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9544:MNAT1
gene id: 9544:MNAT1
uniprot id: A0A8J8YFJ4
uniprot id: H9EPT3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9544:GALM
gene id: 9544:GALM
uniprot id: F7GQT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

9544:ERBIN
gene id: 9544:ERBIN
uniprot id: F7GX50
uniprot id: F7GX54
uniprot id: F7GX57
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9544:BCL2L10
gene id: 9544:BCL2L10
uniprot id: F7H6U5
names: Similarity
messages: Belongs to the Bcl-2 family.

9544:FOXR2
gene id: 9544:FOXR2
uniprot id: A0A8J8XB32
uniprot id: F7D006
names: Subcellular Location Annotation
messages: Nucleus

9544:HOPX
gene id: 9544:HOPX
uniprot id: F7EU22
names: Subcellular Location Annotation
messages: Nucleus

9544:SERPINA4
gene id: 9544:SERPINA4
uniprot id: A0A5F7ZU91
names: Similarity
messages: Belongs to the serpin family.

9544:GFM2
gene id: 9544:GFM2
uniprot id: F7FNF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9544:MTR
gene id: 9544:MTR
uniprot id: A0A8J8YAH3
uniprot id: G7MFM9
uniprot id: I0FRW8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

9544:MAPK6
gene id: 9544:MAPK6
uniprot id: F7GB31
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9544:TMEM106B
gene id: 9544:TMEM106B
uniprot id: A0A1D5Q515
uniprot id: G8F1S7
names: Similarity
messages: Belongs to the TMEM106 family.

9544:CBL
gene id: 9544:CBL
uniprot id: A0A1D5RFE7
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9544:LOC697471
gene id: 9544:LOC697471
uniprot id: F7DGK4
names: Caution
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:LSM6
gene id: 9544:LSM6
uniprot id: A0A8J8Y1R6
uniprot id: F7GFC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9544:SELENOS
gene id: 9544:SELENOS
uniprot id: F7H792
uniprot id: Q3YAK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
messages: Membrane

9544:ST3GAL1
gene id: 9544:ST3GAL1
uniprot id: A0A1D5RE99
uniprot id: A0A8J8XDP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:MAPK8IP3
gene id: 9544:MAPK8IP3
uniprot id: A0A1D5Q3K8
names: Similarity
messages: Belongs to the JIP scaffold family.

9544:C12H2orf88
gene id: 9544:C12H2orf88
uniprot id: A0A8J8YPY4
uniprot id: F7FC58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9544:RAD23A
gene id: 9544:RAD23A
uniprot id: A0A8J8XNZ1
uniprot id: G7NLC4
uniprot id: H9FXY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9544:QTRT2
gene id: 9544:QTRT2
uniprot id: I0FLM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9544:CTNNBL1
gene id: 9544:CTNNBL1
uniprot id: A0A8J8XWH3
uniprot id: F7HE23
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC2A11
gene id: 9544:SLC2A11
uniprot id: G8F1D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane

9544:SLC30A5
gene id: 9544:SLC30A5
uniprot id: F7F761
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9544:PGM1
gene id: 9544:PGM1
uniprot id: A0A5F8A487
uniprot id: A0A8J8YFF9
uniprot id: F7G9Y1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9544:PRKAB1
gene id: 9544:PRKAB1
uniprot id: A0A8J8XAB8
uniprot id: H9EPL6
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9544:UQCRH
gene id: 9544:UQCRH
uniprot id: A0A5K1UEK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9544:HSBP1L1
gene id: 9544:HSBP1L1
uniprot id: H9FMX9
names: Similarity
messages: Belongs to the HSBP1 family.

9544:FBXO9
gene id: 9544:FBXO9
uniprot id: A0A5F8AN90
uniprot id: H9ETM8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9544:SLC16A8
gene id: 9544:SLC16A8
uniprot id: A0A5F7ZDC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9544:S100A11
gene id: 9544:S100A11
uniprot id: F7GN53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

9544:OLFML3
gene id: 9544:OLFML3
uniprot id: A0A8J8YFU4
uniprot id: F7FB04
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:GPNMB
gene id: 9544:GPNMB
uniprot id: A0A5F7ZWL3
uniprot id: A0A5K1U951
names: Similarity
messages: Belongs to the PMEL/NMB family.

9544:FAM131B
gene id: 9544:FAM131B
uniprot id: G7MN60
names: Similarity
messages: Belongs to the FAM131 family.

9544:KRT23
gene id: 9544:KRT23
uniprot id: A0A8J8Y793
uniprot id: F7GFR0
names: Similarity
messages: Belongs to the intermediate filament family.

9544:LOC706675
gene id: 9544:LOC706675
uniprot id: G7NDC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:NFYA
gene id: 9544:NFYA
uniprot id: A0A1D5QSZ7
uniprot id: A0A8J8YSS0
uniprot id: F7H6J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9544:IFNA21
gene id: 9544:IFNA21
uniprot id: A0A7R8GUY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:ST3GAL2
gene id: 9544:ST3GAL2
uniprot id: A0A8J8Y9L7
uniprot id: H9YVE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:PDE2A
gene id: 9544:PDE2A
uniprot id: B3VTJ2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:TMEM206
gene id: 9544:TMEM206
uniprot id: A0A8J8Y613
uniprot id: G7MEL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9544:HYAL1
gene id: 9544:HYAL1
uniprot id: F7GHW3
uniprot id: F7GHW9
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9544:TSR2
gene id: 9544:TSR2
uniprot id: F7F4W3
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9544:KARS
gene id: 9544:KARS
uniprot id: A0A8J8Y8G3
uniprot id: F6TVH1
uniprot id: I0FRI7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9544:SUGP1
gene id: 9544:SUGP1
uniprot id: F6ZCX1
uniprot id: H9ERV6
names: Subcellular Location Annotation
messages: Nucleus

9544:CKS2
gene id: 9544:CKS2
uniprot id: F7E906
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9544:FAM91A1
gene id: 9544:FAM91A1
uniprot id: H9Z076
names: Similarity
messages: Belongs to the FAM91 family.

9544:DTX3L
gene id: 9544:DTX3L
uniprot id: F7G2R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9544:MMP9
gene id: 9544:MMP9
uniprot id: A0A8J8Y654
uniprot id: H9Z944
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

9544:CTNNB1
gene id: 9544:CTNNB1
uniprot id: F7GNE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

9544:COX6A2
gene id: 9544:COX6A2
uniprot id: A0A5F7ZZ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:ACTRT1
gene id: 9544:ACTRT1
uniprot id: A0A8J8XJS7
uniprot id: G7NRD2
names: Similarity
messages: Belongs to the actin family.

9544:CCR7
gene id: 9544:CCR7
uniprot id: Q8HZR6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:IGF1R
gene id: 9544:IGF1R
uniprot id: A0A8J8Y4S9
uniprot id: I2CWY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9544:PRMT5
gene id: 9544:PRMT5
uniprot id: I0FNE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9544:CD4
gene id: 9544:CD4
uniprot id: A0A2Z5GD40
uniprot id: P16003
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs.
messages: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
messages: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
messages: Phosphorylated by PKC; phosphorylation plays an important role for CD4 internalization.
messages: The Ig-like V-type domain mediates the interaction with MHCII.

9544:ACTR2
gene id: 9544:ACTR2
uniprot id: F7BAD3
uniprot id: I2CYF0
names: Similarity
messages: Belongs to the actin family.

9544:LOC704096
gene id: 9544:LOC704096
uniprot id: F7CZF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:NR1H2
gene id: 9544:NR1H2
uniprot id: A0A8J8XDQ9
uniprot id: F7F982
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9544:BMP6
gene id: 9544:BMP6
uniprot id: F7E4H6
names: Similarity
messages: Belongs to the TGF-beta family.

9544:NLK
gene id: 9544:NLK
uniprot id: A0A5F7ZQF4
uniprot id: A0A8J8YSP2
uniprot id: G7NGI5
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9544:SLIT1
gene id: 9544:SLIT1
uniprot id: F7CX22
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:TMEM63C
gene id: 9544:TMEM63C
uniprot id: A0A8J8YRD6
uniprot id: G7MYW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9544:ING2
gene id: 9544:ING2
uniprot id: H9Z017
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9544:JAG1
gene id: 9544:JAG1
uniprot id: I2CVK6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9544:PRPS2
gene id: 9544:PRPS2
uniprot id: H9EPZ0
uniprot id: I0FJ99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9544:DCP1B
gene id: 9544:DCP1B
uniprot id: A0A5F8A4V4
names: Similarity
messages: Belongs to the DCP1 family.

9544:MPEG1
gene id: 9544:MPEG1
uniprot id: H9EXJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

9544:LARP7
gene id: 9544:LARP7
uniprot id: H9FVM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LARP7 family.
messages: nucleoplasm

9544:TMEM265
gene id: 9544:TMEM265
uniprot id: A0A5F8A5G6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:NAB1
gene id: 9544:NAB1
uniprot id: F7GU92
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9544:TEDDM1
gene id: 9544:TEDDM1
uniprot id: F6WLU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9544:CUL4B
gene id: 9544:CUL4B
uniprot id: A0A1D5QSY5
uniprot id: G7NRB7
names: Similarity
messages: Belongs to the cullin family.

9544:PREPL
gene id: 9544:PREPL
uniprot id: A0A8J8Y7N3
uniprot id: G7N9Z5
names: Similarity
messages: Belongs to the peptidase S9A family.

9544:SDR16C5
gene id: 9544:SDR16C5
uniprot id: A0A8J8XGS4
uniprot id: F6W524
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:HSPD1
gene id: 9544:HSPD1
uniprot id: H9FTU5
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9544:LOC718407
gene id: 9544:LOC718407
uniprot id: A0A8J8Y6N6
uniprot id: G7NIJ1
names: Similarity
messages: Belongs to the SUI1 family.

9544:GTPBP3
gene id: 9544:GTPBP3
uniprot id: A0A1D5Q0C0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9544:FEN1
gene id: 9544:FEN1
uniprot id: A0A8J8YHT0
uniprot id: F7H3Z6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Mitochondrion
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9544:KDELR1
gene id: 9544:KDELR1
uniprot id: F7H3E5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:ZDHHC7
gene id: 9544:ZDHHC7
uniprot id: H9EMM2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:RBFOX2
gene id: 9544:RBFOX2
uniprot id: A0A1D5Q718
uniprot id: A0A1D5R9S2
uniprot id: A0A5K1UV26
uniprot id: H9ENR7
uniprot id: H9FS71
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9544:MTMR12
gene id: 9544:MTMR12
uniprot id: A0A5F8AS72
uniprot id: F7HMK6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9544:TMEM19
gene id: 9544:TMEM19
uniprot id: A0A8J8YJT8
uniprot id: H9YVF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9544:ZEB2
gene id: 9544:ZEB2
uniprot id: F7C2Y1
uniprot id: H9G2I9
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9544:ZNF330
gene id: 9544:ZNF330
uniprot id: A0A1D5RKQ6
uniprot id: A0A8J8XTI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: centromere
messages: nucleolus

9544:ESR2
gene id: 9544:ESR2
uniprot id: A0A8J8Y110
uniprot id: I2CWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9544:SENP2
gene id: 9544:SENP2
uniprot id: A0A5K1V6D4
uniprot id: A0A8J8YIL1
names: Similarity
messages: Belongs to the peptidase C48 family.

9544:NOG
gene id: 9544:NOG
uniprot id: F6VTK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9544:ARG2
gene id: 9544:ARG2
uniprot id: A0A8J8YPX4
uniprot id: F7C244
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9544:IL16
gene id: 9544:IL16
uniprot id: O62675
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer (Probable). Pro-interleukin-16 interacts (via PDZ 2 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Pro-interleukin-16 interacts with GRIN2A. Pro-interleukin-16 interacts with GABPB1. Pro-interleukin-16 interacts (via PDZ 3 domain) with HDAC3 (By similarity).
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (By similarity).
messages: Nucleus
messages: Pro-interleukin-16 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells (By similarity).
messages: Secreted

9544:KIF4A
gene id: 9544:KIF4A
uniprot id: F6SF61
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:UBE2C
gene id: 9544:UBE2C
uniprot id: F7HGB1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:AP4S1
gene id: 9544:AP4S1
uniprot id: H9FPB4
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9544:OCRL
gene id: 9544:OCRL
uniprot id: F7EWX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

9544:SRXN1
gene id: 9544:SRXN1
uniprot id: F7H9B2
names: Similarity
messages: Belongs to the sulfiredoxin family.

9544:ECHS1
gene id: 9544:ECHS1
uniprot id: A0A5F7ZWH5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9544:PREB
gene id: 9544:PREB
uniprot id: F6PQ58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9544:BASP1
gene id: 9544:BASP1
uniprot id: H9ERL9
names: Similarity
messages: Belongs to the BASP1 family.

9544:TNR
gene id: 9544:TNR
uniprot id: A0A8J8YJC4
uniprot id: H9ER94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9544:EIF2D
gene id: 9544:EIF2D
uniprot id: F7GX43
uniprot id: I0FIH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9544:MTCP1
gene id: 9544:MTCP1
uniprot id: A0A8J8Y007
uniprot id: F6QM31
names: Similarity
messages: Belongs to the TCL1 family.

9544:DTX2
gene id: 9544:DTX2
uniprot id: A0A8J8YIG4
uniprot id: F6WRL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9544:YME1L1
gene id: 9544:YME1L1
uniprot id: A0A1D5Q861
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9544:CDIPT
gene id: 9544:CDIPT
uniprot id: A0A8J8YHJ3
uniprot id: G7NQI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9544:FAR1
gene id: 9544:FAR1
uniprot id: H9ENN8
uniprot id: H9G0L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9544:ANO6
gene id: 9544:ANO6
uniprot id: A0A5F8ARY8
uniprot id: F7GVV8
uniprot id: G7N6R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9544:NRG4
gene id: 9544:NRG4
uniprot id: F7GSZ7
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:RNF152
gene id: 9544:RNF152
uniprot id: A0A1D5R8J4
uniprot id: A0A8J8XI54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

9544:TACR3
gene id: 9544:TACR3
uniprot id: A0A8J8YM96
uniprot id: Q2WGM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:NDUFB4
gene id: 9544:NDUFB4
uniprot id: F7GV51
uniprot id: G7MKF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:SLC7A1
gene id: 9544:SLC7A1
uniprot id: A0A8J8XBE6
uniprot id: F7F495
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9544:EIF5A2
gene id: 9544:EIF5A2
uniprot id: F6WM55
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

9544:MYD88
gene id: 9544:MYD88
uniprot id: B3Y683
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
messages: Cytoplasm
messages: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1. Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct. Interacts with OTUD4 deubiquitinase; the interaction is direct.
messages: Nucleus
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
messages: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.

9544:FZD10
gene id: 9544:FZD10
uniprot id: F7EZ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

9544:ADGRE2
gene id: 9544:ADGRE2
uniprot id: Q2Q426
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Binding to chondroitin sulfate is mediated by the fourth EGF domain.
messages: Cell membrane
messages: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins.
messages: Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55 (By similarity).
messages: The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.
messages: ruffle membrane

9544:STRADB
gene id: 9544:STRADB
uniprot id: F7F789
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9544:SNAPC3
gene id: 9544:SNAPC3
uniprot id: H9ZCP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

9544:SENP3
gene id: 9544:SENP3
uniprot id: F7HGI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9544:POLH
gene id: 9544:POLH
uniprot id: F7DMW1
names: Subcellular Location Annotation
messages: Nucleus

9544:ZNF24
gene id: 9544:ZNF24
uniprot id: A0A8J8XDA5
uniprot id: F7HLR2
names: Subcellular Location Annotation
messages: Nucleus

9544:QPCT
gene id: 9544:QPCT
uniprot id: G7N9U7
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9544:SLC25A39
gene id: 9544:SLC25A39
uniprot id: A0A8J8YB57
uniprot id: H9EWQ0
uniprot id: H9EWS2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9544:HAUS1
gene id: 9544:HAUS1
uniprot id: A0A8J8XFV4
uniprot id: G7NKN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9544:CCZ1
gene id: 9544:CCZ1
uniprot id: H9H486
names: Similarity
messages: Belongs to the CCZ1 family.

9544:EPHA6
gene id: 9544:EPHA6
uniprot id: F7EGZ3
names: Subcellular Location Annotation
messages: Membrane

9544:PDCD4
gene id: 9544:PDCD4
uniprot id: A0A8J8Y3H2
uniprot id: G7N146
names: Similarity
messages: Belongs to the PDCD4 family.

9544:CLUH
gene id: 9544:CLUH
uniprot id: A0A1D5QEG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

9544:PPP2R2D
gene id: 9544:PPP2R2D
uniprot id: F6X3A7
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9544:PRPF18
gene id: 9544:PRPF18
uniprot id: A0A8J8XE66
uniprot id: F6WVW4
uniprot id: F6WVX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9544:PCNX1
gene id: 9544:PCNX1
uniprot id: A0A1D5RCI2
uniprot id: F6QS22
uniprot id: H9FRJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9544:RPL3
gene id: 9544:RPL3
uniprot id: A0A5F8AHB8
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9544:VAC14
gene id: 9544:VAC14
uniprot id: A0A8J8XD54
uniprot id: F6RXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9544:USP22
gene id: 9544:USP22
uniprot id: H9ENM6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:LRP1
gene id: 9544:LRP1
uniprot id: H9EMK7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:UGT1A1
gene id: 9544:UGT1A1
uniprot id: Q95KM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9544:HNRNPR
gene id: 9544:HNRNPR
uniprot id: A0A5K1VMD8
uniprot id: F7GDH1
uniprot id: H9EPF8
uniprot id: H9YUC9
names: Subcellular Location Annotation
messages: Cytoplasm

9544:LHX6
gene id: 9544:LHX6
uniprot id: A0A1D5QBK8
uniprot id: A0A1D5RDV1
names: Subcellular Location Annotation
messages: Nucleus

9544:INA
gene id: 9544:INA
uniprot id: F7DY27
names: Similarity
messages: Belongs to the intermediate filament family.

9544:HDHD2
gene id: 9544:HDHD2
uniprot id: H9EV26
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9544:PAX6
gene id: 9544:PAX6
uniprot id: F7C9W0
uniprot id: H9FV32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9544:SLC11A1
gene id: 9544:SLC11A1
uniprot id: F6X3X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9544:F5
gene id: 9544:F5
uniprot id: A0A1D5QJP4
names: Similarity
messages: Belongs to the multicopper oxidase family.

9544:ITPA
gene id: 9544:ITPA
uniprot id: A0A8J8XPQ7
uniprot id: F6QR76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9544:SNTB2
gene id: 9544:SNTB2
uniprot id: F6TV85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9544:HTRA2
gene id: 9544:HTRA2
uniprot id: A0A8J8Y9R6
uniprot id: F6UNS8
names: Similarity
messages: Belongs to the peptidase S1C family.

9544:PFDN6
gene id: 9544:PFDN6
uniprot id: A0A8J8YLI3
uniprot id: I0FNG3
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9544:CCND1
gene id: 9544:CCND1
uniprot id: H9FY18
names: Similarity
messages: Belongs to the cyclin family.

9544:SSR1
gene id: 9544:SSR1
uniprot id: F6UGG4
uniprot id: H9ZCT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9544:HOXA3
gene id: 9544:HOXA3
uniprot id: A0A8J8Y0L4
uniprot id: G7MLM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:PTPN13
gene id: 9544:PTPN13
uniprot id: F6S1D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9544:CCS
gene id: 9544:CCS
uniprot id: A0A8J8XN66
uniprot id: F7FL64
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9544:CRYGA
gene id: 9544:CRYGA
uniprot id: A7KK27
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9544:ST3GAL5
gene id: 9544:ST3GAL5
uniprot id: F7A1D7
uniprot id: F7CKA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:SAP130
gene id: 9544:SAP130
uniprot id: A0A5K1URQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9544:CHCHD4
gene id: 9544:CHCHD4
uniprot id: H9EVC9
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9544:RBCK1
gene id: 9544:RBCK1
uniprot id: A0A5K1VSV4
uniprot id: F7F9X2
names: Similarity
messages: Belongs to the RBR family.

9544:SPRYD4
gene id: 9544:SPRYD4
uniprot id: A0A5F8AC55
names: Subcellular Location Annotation
messages: Cytoplasm

9544:HTR1E
gene id: 9544:HTR1E
uniprot id: A0A8J8XJN8
uniprot id: F6XHK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:LSM1
gene id: 9544:LSM1
uniprot id: A0A8J8YJI8
uniprot id: G7MZ45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9544:C14H11orf87
gene id: 9544:C14H11orf87
uniprot id: F7E0Q9
names: Subcellular Location Annotation
messages: Membrane

9544:MAP2K2
gene id: 9544:MAP2K2
uniprot id: H9EUI5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:LOC707215
gene id: 9544:LOC707215
uniprot id: F7H3X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9544:COG4
gene id: 9544:COG4
uniprot id: H9ESY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9544:TCEANC
gene id: 9544:TCEANC
uniprot id: F6Z6I9
names: Subcellular Location Annotation
messages: Nucleus

9544:GHITM
gene id: 9544:GHITM
uniprot id: F6YLT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9544:PHPT1
gene id: 9544:PHPT1
uniprot id: H9ER03
names: Function
names: Similarity
messages: Belongs to the janus family.
messages: Exhibits phosphohistidine phosphatase activity.

9544:FPGS
gene id: 9544:FPGS
uniprot id: I2CTG4
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

9544:KCNA10
gene id: 9544:KCNA10
uniprot id: F7HL26
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:TRAP1
gene id: 9544:TRAP1
uniprot id: F7EHQ6
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9544:ATPAF2
gene id: 9544:ATPAF2
uniprot id: A0A8J8XAV3
uniprot id: H9YWY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9544:UTS2
gene id: 9544:UTS2
uniprot id: Q8HYC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Highly potent vasoconstrictor.
messages: Secreted

9544:TEAD2
gene id: 9544:TEAD2
uniprot id: A0A5F8AB76
uniprot id: F6WCY5
uniprot id: F6ZGU9
names: Subcellular Location Annotation
messages: Nucleus

9544:MAP3K8
gene id: 9544:MAP3K8
uniprot id: A0A5K1VGZ7
uniprot id: F7CDF3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9544:CSTB
gene id: 9544:CSTB
uniprot id: H9EXJ7
names: Similarity
messages: Belongs to the cystatin family.

9544:KCNN1
gene id: 9544:KCNN1
uniprot id: F6T3L2
uniprot id: H9FU72
names: Subcellular Location Annotation
messages: Membrane

9544:NDST1
gene id: 9544:NDST1
uniprot id: F7GSZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9544:TRHR
gene id: 9544:TRHR
uniprot id: A0A8J8YC16
uniprot id: F7DWM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9544:EMX1
gene id: 9544:EMX1
uniprot id: F7AFG5
names: Subcellular Location Annotation
messages: Nucleus

9544:LLPH
gene id: 9544:LLPH
uniprot id: A0A8J8XBA6
uniprot id: F6TQE1
names: Similarity
messages: Belongs to the learning-associated protein family.

9544:CASTOR2
gene id: 9544:CASTOR2
uniprot id: H9ZD32
names: Similarity
messages: Belongs to the GATS family.

9544:OTUD7B
gene id: 9544:OTUD7B
uniprot id: A0A8J8Y7V2
uniprot id: F7BEE5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:HYI
gene id: 9544:HYI
uniprot id: F7GXP8
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

9544:ETV5
gene id: 9544:ETV5
uniprot id: A0A8J8XAL8
uniprot id: G7MJ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:SLC25A40
gene id: 9544:SLC25A40
uniprot id: F7H3V4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9544:TMEM263
gene id: 9544:TMEM263
uniprot id: A0A8J8YS10
uniprot id: F6WHZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9544:RPS9
gene id: 9544:RPS9
uniprot id: A0A8J8XJR6
uniprot id: F7H3C4
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9544:IL11RA
gene id: 9544:IL11RA
uniprot id: F7H9Z9
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9544:UFD1
gene id: 9544:UFD1
uniprot id: H9EMR8
names: Similarity
messages: Belongs to the UFD1 family.

9544:C19H19orf53
gene id: 9544:C19H19orf53
uniprot id: I2CYD4
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9544:KIF13A
gene id: 9544:KIF13A
uniprot id: F7G1S8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:B3GALT2
gene id: 9544:B3GALT2
uniprot id: F7FM56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:TRIM36
gene id: 9544:TRIM36
uniprot id: A0A1D5QZ67
uniprot id: A0A8J8XN02
uniprot id: F7CIJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

9544:AOX4
gene id: 9544:AOX4
uniprot id: M1ZMN2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9544:TMOD4
gene id: 9544:TMOD4
uniprot id: A0A8J8YEG3
uniprot id: F6PSC9
names: Subcellular Location Annotation
messages: cytoskeleton

9544:PSMD13
gene id: 9544:PSMD13
uniprot id: H9FXJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9544:COX6B1
gene id: 9544:COX6B1
uniprot id: Q53CG4
names: Function
names: Subcellular Location Annotation
messages: Connects the two COX monomers into the physiological dimeric form.
messages: Mitochondrion intermembrane space

9544:REXO2
gene id: 9544:REXO2
uniprot id: A0A8J8XME3
uniprot id: F6UYS2
names: Similarity
messages: Belongs to the oligoribonuclease family.

9544:B3GAT2
gene id: 9544:B3GAT2
uniprot id: A0A5F7ZC00
uniprot id: A0A5F8AKT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:LCN8
gene id: 9544:LCN8
uniprot id: D1YSI8
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9544:IFNL1
gene id: 9544:IFNL1
uniprot id: F7G050
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9544:LOC711440
gene id: 9544:LOC711440
uniprot id: A0A1D5QHM1
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9544:PLA2G15
gene id: 9544:PLA2G15
uniprot id: A0A1D5RAG6
uniprot id: A0A8J8XQP7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9544:MRPS21
gene id: 9544:MRPS21
uniprot id: A0A8J8YET2
uniprot id: G7MDH3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9544:GNAT2
gene id: 9544:GNAT2
uniprot id: A0A8J8Y1P3
uniprot id: F6VKI4
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:ACAP1
gene id: 9544:ACAP1
uniprot id: F7HLN4
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9544:HSD17B3
gene id: 9544:HSD17B3
uniprot id: A0A1D5RKB3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:STX18
gene id: 9544:STX18
uniprot id: F6VA15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9544:BMT2
gene id: 9544:BMT2
uniprot id: A0A8J8XVT5
uniprot id: G7MM54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9544:NAPEPLD
gene id: 9544:NAPEPLD
uniprot id: F6YX59
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

9544:FLI1
gene id: 9544:FLI1
uniprot id: H9Z2K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:TNFRSF21
gene id: 9544:TNFRSF21
uniprot id: A0A8J8YRP0
uniprot id: G7MPI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:DZIP3
gene id: 9544:DZIP3
uniprot id: F6REG1
names: Subcellular Location Annotation
messages: Cytoplasm

9544:OSBP
gene id: 9544:OSBP
uniprot id: H9Z9F5
names: Similarity
messages: Belongs to the OSBP family.

9544:BCAP29
gene id: 9544:BCAP29
uniprot id: F7HKA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9544:ABCB9
gene id: 9544:ABCB9
uniprot id: A0A8J8XDW5
uniprot id: G7N637
names: Subcellular Location Annotation
messages: Membrane

9544:MCTP2
gene id: 9544:MCTP2
uniprot id: A0A8J8XRA0
uniprot id: G7MW13
names: Subcellular Location Annotation
messages: Membrane

9544:ISY1
gene id: 9544:ISY1
uniprot id: A0A1D5QH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9544:MAPK10
gene id: 9544:MAPK10
uniprot id: A0A1D5QMC7
uniprot id: A0A8J8YAK3
uniprot id: F7GN93
uniprot id: F7HRW7
uniprot id: F7HRW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9544:RANBP10
gene id: 9544:RANBP10
uniprot id: I2CV23
names: Similarity
messages: Belongs to the RANBP9/10 family.

9544:MRGPRX4
gene id: 9544:MRGPRX4
uniprot id: Q1L4E5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:SLC25A31
gene id: 9544:SLC25A31
uniprot id: A0A8J8XRI5
uniprot id: F6VUM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9544:STX6
gene id: 9544:STX6
uniprot id: A0A5K1U1A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9544:NELFE
gene id: 9544:NELFE
uniprot id: G7MRL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

9544:KEG06 p09
gene id: 9544:KEG06_p09
uniprot id: Q6IYH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9544:GPHN
gene id: 9544:GPHN
uniprot id: A0A8J8YN59
uniprot id: H9FNK4
uniprot id: H9Z463
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9544:TCEA1
gene id: 9544:TCEA1
uniprot id: A0A1D5Q638
uniprot id: H9FZ09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9544:LOC100426798
gene id: 9544:LOC100426798
uniprot id: F7FMW4
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9544:ABRAXAS1
gene id: 9544:ABRAXAS1
uniprot id: H9ZEA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Nucleus

9544:FABP7
gene id: 9544:FABP7
uniprot id: F6TB55
uniprot id: G7MQL6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:VSX1
gene id: 9544:VSX1
uniprot id: A0A5F8A2B9
names: Subcellular Location Annotation
messages: Nucleus

9544:MAMU-E
gene id: 9544:MAMU-E
uniprot id: Q5TM58
names: Similarity
messages: Belongs to the MHC class I family.

9544:ADRA2A
gene id: 9544:ADRA2A
uniprot id: A0A1D5Q7E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:TRIM14
gene id: 9544:TRIM14
uniprot id: F7GJE0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:PREP
gene id: 9544:PREP
uniprot id: A0A8J8Y318
uniprot id: H9FWT3
names: Similarity
messages: Belongs to the peptidase S9A family.

9544:EIF3H
gene id: 9544:EIF3H
uniprot id: F6UCC5
uniprot id: G7MZZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9544:SLC12A9
gene id: 9544:SLC12A9
uniprot id: G7MNV9
uniprot id: I0FTL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9544:ALDH18A1
gene id: 9544:ALDH18A1
uniprot id: A0A8J8XRJ8
uniprot id: G7N2M0
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9544:FAM187B
gene id: 9544:FAM187B
uniprot id: A0A8J8YF02
uniprot id: F6UPE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9544:WNT4
gene id: 9544:WNT4
uniprot id: A0A5F7ZTQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:RAP1GDS1
gene id: 9544:RAP1GDS1
uniprot id: A0A5K1U816
uniprot id: I0FHU6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion

9544:MICAL1
gene id: 9544:MICAL1
uniprot id: F7EAH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9544:PRR15L
gene id: 9544:PRR15L
uniprot id: A0A8J8Y833
uniprot id: F7EHE4
names: Similarity
messages: Belongs to the PRR15 family.

9544:TERF2IP
gene id: 9544:TERF2IP
uniprot id: H9FW07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9544:PLBD2
gene id: 9544:PLBD2
uniprot id: I2CYI6
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9544:PGGT1B
gene id: 9544:PGGT1B
uniprot id: A0A8J8XJ20
uniprot id: F7ALE0
uniprot id: G7MVK1
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9544:RAB3B
gene id: 9544:RAB3B
uniprot id: I2CYC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9544:STRADA
gene id: 9544:STRADA
uniprot id: A0A1D5QYD1
uniprot id: A0A8J8XWQ0
uniprot id: F7AHH3
uniprot id: H9G1U4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9544:NGLY1
gene id: 9544:NGLY1
uniprot id: F6WC45
uniprot id: F6WCT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

9544:RNF39
gene id: 9544:RNF39
uniprot id: Q5TM52
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May play a role in prolonged long term-potentiation (LTP) maintenance.

9544:PUS10
gene id: 9544:PUS10
uniprot id: A0A8J8XUK5
uniprot id: F6U5F7
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

9544:ADGRE1
gene id: 9544:ADGRE1
uniprot id: F7GQC7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:NDUFS3
gene id: 9544:NDUFS3
uniprot id: A0A8J8XFK7
uniprot id: H9YW62
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

9544:ALG3
gene id: 9544:ALG3
uniprot id: H9EVM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:UGP2
gene id: 9544:UGP2
uniprot id: F7DKM9
uniprot id: H9Z0R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9544:MRGPRX1
gene id: 9544:MRGPRX1
uniprot id: Q1L4E8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:FBXO45
gene id: 9544:FBXO45
uniprot id: A0A5F7ZC38
names: Similarity
messages: Belongs to the FBXO45/Fsn family.

9544:GFM1
gene id: 9544:GFM1
uniprot id: F6UK19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9544:SCGB1C1
gene id: 9544:SCGB1C1
uniprot id: A0A8J8YLT6
uniprot id: F7D241
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9544:DR1
gene id: 9544:DR1
uniprot id: A0A8J8YJE8
uniprot id: F7C9G1
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9544:LIMS2
gene id: 9544:LIMS2
uniprot id: I2CUQ1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9544:RPL6
gene id: 9544:RPL6
uniprot id: F6WKH0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9544:C4H6orf15
gene id: 9544:C4H6orf15
uniprot id: Q9BGL9
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to numerous extracellular matrix proteins.
messages: Taste cell specific.
messages: extracellular matrix

9544:DHH
gene id: 9544:DHH
uniprot id: A0A8J8XBT7
uniprot id: G7N6V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9544:NCR3
gene id: 9544:NCR3
uniprot id: Q8MJ02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation.
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.

9544:MTHFS
gene id: 9544:MTHFS
uniprot id: A0A8J8XM46
uniprot id: F6VVW7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

9544:EFHC1
gene id: 9544:EFHC1
uniprot id: A0A8J8XA94
uniprot id: F6S496
names: Subcellular Location Annotation
messages: cilium axoneme

9544:GATA4
gene id: 9544:GATA4
uniprot id: I2CWU8
names: Subcellular Location Annotation
messages: Nucleus

9544:IL13RA2
gene id: 9544:IL13RA2
uniprot id: F6Z890
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.
messages: Membrane

9544:TNKS2
gene id: 9544:TNKS2
uniprot id: H9ZDV5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:LOC704365
gene id: 9544:LOC704365
uniprot id: A0A8J8YRI1
uniprot id: F7DWL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9544:B9D1
gene id: 9544:B9D1
uniprot id: F7H5W8
names: Subcellular Location Annotation
messages: cilium basal body

9544:CD63
gene id: 9544:CD63
uniprot id: A0A8J8Y1E7
uniprot id: F6XET9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9544:C18H18orf32
gene id: 9544:C18H18orf32
uniprot id: F7CL30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: Lipid droplet
messages: May activate the NF-kappa-B signaling pathway.

9544:VMA21
gene id: 9544:VMA21
uniprot id: A0A8J8YH39
uniprot id: F7FG76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9544:CORO7
gene id: 9544:CORO7
uniprot id: F7H977
names: Similarity
messages: Belongs to the WD repeat coronin family.

9544:SARS2
gene id: 9544:SARS2
uniprot id: H9EXI9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9544:PLXNA4
gene id: 9544:PLXNA4
uniprot id: F7BXM1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:AK6
gene id: 9544:AK6
uniprot id: H9FZ00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9544:APOLD1
gene id: 9544:APOLD1
uniprot id: A0A5F8AMQ2
names: Similarity
messages: Belongs to the apolipoprotein L family.

9544:RIMKLB
gene id: 9544:RIMKLB
uniprot id: H9EPS3
names: Similarity
messages: Belongs to the RimK family.

9544:TWSG1
gene id: 9544:TWSG1
uniprot id: A0A8J8Y0I6
uniprot id: F7G4Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

9544:ARL14
gene id: 9544:ARL14
uniprot id: G7MJD9
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9544:POLR2G
gene id: 9544:POLR2G
uniprot id: A0A1D5R0T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9544:CDK6
gene id: 9544:CDK6
uniprot id: A0A8J8YT09
uniprot id: H9EMN3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:TMEM150C
gene id: 9544:TMEM150C
uniprot id: A0A1D5QU87
uniprot id: A0A8J8XNI0
uniprot id: G7MSX4
names: Subcellular Location Annotation
messages: Membrane

9544:LOC696872
gene id: 9544:LOC696872
uniprot id: A0A8J8XDH1
uniprot id: F7HAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9544:SLC43A3
gene id: 9544:SLC43A3
uniprot id: F7BRN1
names: Subcellular Location Annotation
messages: Membrane

9544:PSIP1
gene id: 9544:PSIP1
uniprot id: H9ETF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9544:MCOLN1
gene id: 9544:MCOLN1
uniprot id: I2CVV6
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9544:XYLT1
gene id: 9544:XYLT1
uniprot id: F7H2Y6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

9544:AP1G2
gene id: 9544:AP1G2
uniprot id: A0A8J8XGJ3
uniprot id: F6XKB0
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9544:EFNA3
gene id: 9544:EFNA3
uniprot id: A0A1D5QCP5
uniprot id: I2CYI5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:FAM129B
gene id: 9544:FAM129B
uniprot id: I0FUA6
names: Similarity
messages: Belongs to the Niban family.

9544:DMRT1
gene id: 9544:DMRT1
uniprot id: I2CWK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9544:RBM10
gene id: 9544:RBM10
uniprot id: F7HPQ5
uniprot id: G7NT37
uniprot id: H9ZE28
names: Subcellular Location Annotation
messages: Nucleus

9544:TSSC4
gene id: 9544:TSSC4
uniprot id: A0A8J8YIA4
uniprot id: G7NBM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TSSC4 family.
messages: Cytoplasm
messages: Nucleus

9544:AK2
gene id: 9544:AK2
uniprot id: A0A1D5QK39
uniprot id: A0A1D5RIB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9544:PPFIA2
gene id: 9544:PPFIA2
uniprot id: F6T6Z8
uniprot id: H9G107
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9544:SSBP3
gene id: 9544:SSBP3
uniprot id: A0A5F7ZAU9
uniprot id: F7HMU7
uniprot id: H9Z778
names: Subcellular Location Annotation
messages: Nucleus

9544:NAA40
gene id: 9544:NAA40
uniprot id: H9FZX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

9544:DERL3
gene id: 9544:DERL3
uniprot id: A0A5S6RAL0
uniprot id: G8F1D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9544:LGMN
gene id: 9544:LGMN
uniprot id: G7MZ11
names: Similarity
messages: Belongs to the peptidase C13 family.

9544:IGFBP1
gene id: 9544:IGFBP1
uniprot id: A0A1D5QTL3
uniprot id: A0A8J8XCK2
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:CYP2C75
gene id: 9544:CYP2C75
uniprot id: Q6GUQ6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:LOC709878
gene id: 9544:LOC709878
uniprot id: G7NS87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9544:DDIT4L
gene id: 9544:DDIT4L
uniprot id: A0A8J8XDT6
uniprot id: F7EST5
names: Similarity
messages: Belongs to the DDIT4 family.

9544:SND1
gene id: 9544:SND1
uniprot id: A0A8J8YGX9
uniprot id: G7MMA3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9544:SEC24A
gene id: 9544:SEC24A
uniprot id: F7C397
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9544:LOC703298
gene id: 9544:LOC703298
uniprot id: F7HMW2
uniprot id: F7HMY2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9544:TTC27
gene id: 9544:TTC27
uniprot id: F7HF56
names: Similarity
messages: Belongs to the TTC27 family.

9544:SULF2
gene id: 9544:SULF2
uniprot id: G7N4L2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9544:CDX4
gene id: 9544:CDX4
uniprot id: A0A8J8YF80
uniprot id: F6YHI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9544:GALNT10
gene id: 9544:GALNT10
uniprot id: F7BKN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:DEFB119
gene id: 9544:DEFB119
uniprot id: G7N561
uniprot id: I0FIH0
uniprot id: Q5J602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant expression in the male reproductive tract only. Expressed abundantly in testis, while expression in epididymis decreased gradually from caput to cauda.
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:KCTD6
gene id: 9544:KCTD6
uniprot id: A0A8J8XPG1
uniprot id: G7MKZ6
names: Subcellular Location Annotation
messages: Cell membrane

9544:LOC696128
gene id: 9544:LOC696128
uniprot id: F6TY89
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9544:FGF4
gene id: 9544:FGF4
uniprot id: A0A7U3JW21
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:ALG5
gene id: 9544:ALG5
uniprot id: A0A8J8YDE1
uniprot id: F7EN62
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9544:CDC37L1
gene id: 9544:CDC37L1
uniprot id: A0A8J8YNF7
uniprot id: F7BDY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9544:TMEM107
gene id: 9544:TMEM107
uniprot id: H9ERC2
names: Subcellular Location Annotation
messages: Membrane

9544:CACNB4
gene id: 9544:CACNB4
uniprot id: A0A1D5QD77
uniprot id: A0A1D5QRN7
uniprot id: F7B1R4
uniprot id: F7B1S0
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9544:MTMR4
gene id: 9544:MTMR4
uniprot id: I2CVE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9544:ATP13A2
gene id: 9544:ATP13A2
uniprot id: F7GUW3
uniprot id: F7GUX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9544:BCAR1
gene id: 9544:BCAR1
uniprot id: A0A5F8AK84
uniprot id: I0FWM3
uniprot id: I0FWM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9544:ILDR2
gene id: 9544:ILDR2
uniprot id: A0A1D5QEF6
uniprot id: A0A1D5RGB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9544:CD38
gene id: 9544:CD38
uniprot id: A0A8J8YAE3
uniprot id: F6QEE7
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9544:OR52N4
gene id: 9544:OR52N4
uniprot id: G7NE26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:SPSB1
gene id: 9544:SPSB1
uniprot id: A0A8J8Y8C2
uniprot id: F7GGS2
names: Similarity
messages: Belongs to the SPSB family.

9544:OXT
gene id: 9544:OXT
uniprot id: F7AXI7
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9544:SEMA5A
gene id: 9544:SEMA5A
uniprot id: I2CT92
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:HDAC6
gene id: 9544:HDAC6
uniprot id: A0A5K1VJH7
uniprot id: H9ER82
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

9544:DVL1
gene id: 9544:DVL1
uniprot id: A0A1D5QEW3
uniprot id: H9Z605
names: Similarity
messages: Belongs to the DSH family.

9544:COPS4
gene id: 9544:COPS4
uniprot id: A0A1D5Q7W7
uniprot id: A0A8J8YQF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9544:GHV
gene id: 9544:GHV
uniprot id: A0A5F7ZB15
uniprot id: Q07370
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the somatotropin/prolactin family.
messages: Expressed in the placenta.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9544:RBP1
gene id: 9544:RBP1
uniprot id: F7A9X9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:PA2G4
gene id: 9544:PA2G4
uniprot id: I0FGA6
names: Similarity
messages: Belongs to the peptidase M24 family.

9544:CTNNAL1
gene id: 9544:CTNNAL1
uniprot id: F6YZM1
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9544:GALNT12
gene id: 9544:GALNT12
uniprot id: F7BMV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:NME6
gene id: 9544:NME6
uniprot id: G7MIQ7
names: Similarity
messages: Belongs to the NDK family.

9544:GINS4
gene id: 9544:GINS4
uniprot id: A0A8J8YSV6
uniprot id: F7E9E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9544:MED29
gene id: 9544:MED29
uniprot id: H9FWU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9544:SLC2A1
gene id: 9544:SLC2A1
uniprot id: F6YFI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Membrane
messages: Photoreceptor inner segment

9544:C13H2orf49
gene id: 9544:C13H2orf49
uniprot id: A0A5F8AKU4
uniprot id: A0A8J8YJ66
uniprot id: F6V435
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9544:BHMT2
gene id: 9544:BHMT2
uniprot id: A0A1D5QR99
uniprot id: A0A8J8Y700
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9544:MAMU-DQA1
gene id: 9544:MAMU-DQA1
uniprot id: A5JL31
names: Similarity
messages: Belongs to the MHC class II family.

9544:MBTPS1
gene id: 9544:MBTPS1
uniprot id: G7NPE6
names: Similarity
messages: Belongs to the peptidase S8 family.

9544:ATP1B1
gene id: 9544:ATP1B1
uniprot id: F7GY84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9544:TRIM56
gene id: 9544:TRIM56
uniprot id: A0A8J8YF63
uniprot id: G7MNW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9544:SLC35A4
gene id: 9544:SLC35A4
uniprot id: G7MUY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:NACC2
gene id: 9544:NACC2
uniprot id: F6X1Q6
names: Subcellular Location Annotation
messages: Nucleus

9544:PDS5A
gene id: 9544:PDS5A
uniprot id: H9ENX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDS5 family.
messages: Nucleus

9544:MFSD6
gene id: 9544:MFSD6
uniprot id: F7FBJ5
uniprot id: I2CU41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9544:DYNC1I1
gene id: 9544:DYNC1I1
uniprot id: A0A1D5QMK2
uniprot id: A0A8J8YT71
uniprot id: F6UKZ4
uniprot id: F6WW23
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9544:SLF2
gene id: 9544:SLF2
uniprot id: H9FWZ9
names: Similarity
messages: Belongs to the FAM178 family.

9544:PLAC8
gene id: 9544:PLAC8
uniprot id: A0A8J8XJ76
uniprot id: F6U372
names: Similarity
messages: Belongs to the cornifelin family.

9544:PRPF38A
gene id: 9544:PRPF38A
uniprot id: H9EQH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9544:ACTC1
gene id: 9544:ACTC1
uniprot id: A0A8J8YF68
uniprot id: F7F210
names: Similarity
messages: Belongs to the actin family.

9544:PTH2
gene id: 9544:PTH2
uniprot id: A0A8J8YSQ1
uniprot id: F6W651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

9544:SNX2
gene id: 9544:SNX2
uniprot id: A0A5F8AK91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9544:RAB33A
gene id: 9544:RAB33A
uniprot id: A0A8J8XPZ0
uniprot id: G7NRE5
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9544:MED27
gene id: 9544:MED27
uniprot id: A0A8J8XJN5
uniprot id: F7GN97
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9544:CCDC58
gene id: 9544:CCDC58
uniprot id: F7HMS8
names: Similarity
messages: Belongs to the MIX23 family.

9544:SLC6A19
gene id: 9544:SLC6A19
uniprot id: F7GJ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9544:CHMP7
gene id: 9544:CHMP7
uniprot id: H9EQE2
names: Similarity
messages: Belongs to the SNF7 family.

9544:C3H7orf25
gene id: 9544:C3H7orf25
uniprot id: G7MLF6
names: Similarity
messages: Belongs to the UPF0415 family.

9544:XPNPEP1
gene id: 9544:XPNPEP1
uniprot id: A0A5K1VLA6
uniprot id: A0A8J8YAX7
uniprot id: H9ZD83
names: Similarity
messages: Belongs to the peptidase M24B family.

9544:PLPP1
gene id: 9544:PLPP1
uniprot id: I2CT37
uniprot id: I2CTE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:TBC1D23
gene id: 9544:TBC1D23
uniprot id: A0A8J8YCH0
uniprot id: F7GGM6
uniprot id: G7MK14
names: Subcellular Location Annotation
messages: trans-Golgi network

9544:ABCB11
gene id: 9544:ABCB11
uniprot id: F6SYV4
names: Subcellular Location Annotation
messages: Membrane

9544:ABCB8
gene id: 9544:ABCB8
uniprot id: F7GX83
names: Subcellular Location Annotation
messages: Membrane

9544:BTAF1
gene id: 9544:BTAF1
uniprot id: H9G1J4
names: Subcellular Location Annotation
messages: Nucleus

9544:RAX2
gene id: 9544:RAX2
uniprot id: A0A8J8XMX4
uniprot id: F6YCG6
names: Subcellular Location Annotation
messages: Nucleus

9544:A4GALT
gene id: 9544:A4GALT
uniprot id: G7N441
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9544:IER3IP1
gene id: 9544:IER3IP1
uniprot id: H9FV94
names: Similarity
messages: Belongs to the YOS1 family.

9544:CBX5
gene id: 9544:CBX5
uniprot id: A0A8J8Y6P4
uniprot id: F7C841
names: Subcellular Location Annotation
messages: Nucleus

9544:DGCR2
gene id: 9544:DGCR2
uniprot id: H9EQV8
uniprot id: H9EQW7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:PMP22
gene id: 9544:PMP22
uniprot id: A0A8J8Y435
uniprot id: F6W2G0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

9544:FGFR1OP
gene id: 9544:FGFR1OP
uniprot id: F6VQF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9544:KLHL15
gene id: 9544:KLHL15
uniprot id: A0A8J8XU82
uniprot id: F6RME8
names: Subcellular Location Annotation
messages: Nucleus

9544:RXFP1
gene id: 9544:RXFP1
uniprot id: F6T6T5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:VPS37D
gene id: 9544:VPS37D
uniprot id: I0FPI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9544:VWC2L
gene id: 9544:VWC2L
uniprot id: A0A8J8XYB9
uniprot id: G7N8U3
names: Subcellular Location Annotation
messages: Synapse

9544:UCN2
gene id: 9544:UCN2
uniprot id: F7GTP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9544:MGME1
gene id: 9544:MGME1
uniprot id: A0A8J8YIY1
uniprot id: F7ADZ7
uniprot id: H9ZFD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGME1 family.
messages: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.
messages: Mitochondrion

9544:GLOD4
gene id: 9544:GLOD4
uniprot id: H9EV69
names: Similarity
messages: Belongs to the glyoxalase I family.

9544:ETFA
gene id: 9544:ETFA
uniprot id: A0A1D5R7W8
uniprot id: A0A8J8XZM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9544:PKLR
gene id: 9544:PKLR
uniprot id: A0A5F7ZB67
names: Similarity
messages: Belongs to the pyruvate kinase family.

9544:GNPAT
gene id: 9544:GNPAT
uniprot id: F6VSZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9544:MAST3
gene id: 9544:MAST3
uniprot id: A0A5F7Z984
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9544:FOXB1
gene id: 9544:FOXB1
uniprot id: F7D628
names: Subcellular Location Annotation
messages: Nucleus

9544:XPOT
gene id: 9544:XPOT
uniprot id: F7DBX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9544:STAMBPL1
gene id: 9544:STAMBPL1
uniprot id: F7EC45
names: Similarity
messages: Belongs to the peptidase M67C family.

9544:PCK1
gene id: 9544:PCK1
uniprot id: A0A8J8XP28
uniprot id: F6ZDT7
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Monomer.

9544:KIAA1191
gene id: 9544:KIAA1191
uniprot id: A0A1D5QAK4
uniprot id: A0A1D5R638
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9544:DLX1
gene id: 9544:DLX1
uniprot id: F7F2R0
names: Subcellular Location Annotation
messages: Nucleus

9544:AHSA1
gene id: 9544:AHSA1
uniprot id: A0A1D5QXA8
uniprot id: A0A8J8XHG8
names: Similarity
messages: Belongs to the AHA1 family.

9544:RBM46
gene id: 9544:RBM46
uniprot id: G7MS66
names: Subcellular Location Annotation
messages: Cytoplasm

9544:CFAP298
gene id: 9544:CFAP298
uniprot id: A0A1D5QDN3
uniprot id: A0A8J8Y0R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9544:ROCK2
gene id: 9544:ROCK2
uniprot id: A0A5K1VEY0
uniprot id: H9G236
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane
messages: Nucleus
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
messages: centrosome

9544:AOX1
gene id: 9544:AOX1
uniprot id: M1ZMN0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9544:PPP3R1
gene id: 9544:PPP3R1
uniprot id: H9EN69
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9544:LIN7B
gene id: 9544:LIN7B
uniprot id: H9EQG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9544:GRP
gene id: 9544:GRP
uniprot id: F6SRX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9544:MCEE
gene id: 9544:MCEE
uniprot id: A0A5F7ZLR6
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9544:MYC
gene id: 9544:MYC
uniprot id: B8XIA5
uniprot id: G7N040
names: Biotechnology
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Alternative translation initiation from an upstream, in-frame non-ATG (CTG) codon or a downstream ATG start site results in the production of 2 isoforms with distinct N-termini, shown in this entry as isoform 2 and isoform 1, respectively.
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-73 and Ser-77) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity). Interacts with CIP2A; leading to the stabilization of MYC (By similarity).
messages: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
messages: Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-344 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-77 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-77 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-73. Phosphorylation at Thr-73 and Ser-77 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-77 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).
messages: Produced by alternative translation initiation from a CTG codon, which is translated as Met.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
messages: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-73 and Ser-77, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.
messages: nucleolus
messages: nucleoplasm

9544:MAP6
gene id: 9544:MAP6
uniprot id: F7D5N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

9544:ASPDH
gene id: 9544:ASPDH
uniprot id: A0A1D5QVH6
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9544:EXOSC1
gene id: 9544:EXOSC1
uniprot id: A0A8J8XPM4
uniprot id: I0FS73
names: Subcellular Location Annotation
messages: Cytoplasm

9544:GRHL1
gene id: 9544:GRHL1
uniprot id: F6ZAV1
names: Subcellular Location Annotation
messages: Nucleus

9544:HSPA4L
gene id: 9544:HSPA4L
uniprot id: A0A1D5R641
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9544:ANO10
gene id: 9544:ANO10
uniprot id: F7D1X4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:MMP14
gene id: 9544:MMP14
uniprot id: A0A8J8XW88
uniprot id: F7GFT1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Cytoplasm
messages: Melanosome

9544:KRR1
gene id: 9544:KRR1
uniprot id: F6YQM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9544:PLPP2
gene id: 9544:PLPP2
uniprot id: H9G165
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:P2RY1
gene id: 9544:P2RY1
uniprot id: A0A8J8XZQ6
uniprot id: F6V1F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:TMEM94
gene id: 9544:TMEM94
uniprot id: A0A1D5RGG1
names: Subcellular Location Annotation
messages: Membrane

9544:MAMU-DRA
gene id: 9544:MAMU-DRA
uniprot id: A0A8J8XEP6
uniprot id: Q6EWK7
uniprot id: Q6EWK9
uniprot id: Q6EWL5
names: Similarity
messages: Belongs to the MHC class II family.

9544:EID2B
gene id: 9544:EID2B
uniprot id: G7MPU7
names: Subcellular Location Annotation
messages: Nucleus

9544:HIST1H2BJ
gene id: 9544:HIST1H2BJ
uniprot id: H9H2V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:RIC3
gene id: 9544:RIC3
uniprot id: H9FZT0
names: Similarity
messages: Belongs to the ric-3 family.

9544:TSPAN13
gene id: 9544:TSPAN13
uniprot id: A0A8J8XX59
uniprot id: G7MLR5
names: Subcellular Location Annotation
messages: Membrane

9544:C4H6orf89
gene id: 9544:C4H6orf89
uniprot id: F7AMW7
uniprot id: F7AMX4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9544:RPL34
gene id: 9544:RPL34
uniprot id: A0A8J8YRI1
uniprot id: F7DWL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9544:TBC1D7
gene id: 9544:TBC1D7
uniprot id: A0A8J8YFB9
uniprot id: F7GT45
uniprot id: G7MQR4
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9544:NCSTN
gene id: 9544:NCSTN
uniprot id: F7EHX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9544:PPP1R2C
gene id: 9544:PPP1R2C
uniprot id: A0A8J8Y8K7
uniprot id: F7GFL6
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9544:CRX
gene id: 9544:CRX
uniprot id: A0A5F7ZEA9
names: Subcellular Location Annotation
messages: Nucleus

9544:CLU
gene id: 9544:CLU
uniprot id: F6S885
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
messages: Membrane
messages: Microsome
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9544:CHAC2
gene id: 9544:CHAC2
uniprot id: A0A5F8A516
uniprot id: A0A8J8Y141
uniprot id: F7BCW7
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9544:EHD2
gene id: 9544:EHD2
uniprot id: A0A8J8XNE1
uniprot id: G7NNN2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9544:PWP2
gene id: 9544:PWP2
uniprot id: H9ERN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9544:LRRC8B
gene id: 9544:LRRC8B
uniprot id: A0A1D5QGF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9544:SIAH2
gene id: 9544:SIAH2
uniprot id: F6TED2
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9544:PTEN
gene id: 9544:PTEN
uniprot id: H9YWL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
messages: Belongs to the PTEN phosphatase protein family.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

9544:ITK
gene id: 9544:ITK
uniprot id: A0A8J8XH04
uniprot id: F7GS57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9544:RPL39
gene id: 9544:RPL39
uniprot id: F7GZH5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9544:FAM120B
gene id: 9544:FAM120B
uniprot id: A0A1D5QFK4
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9544:CD79A
gene id: 9544:CD79A
uniprot id: A0A8J8XN05
uniprot id: G7NLK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:OTX1
gene id: 9544:OTX1
uniprot id: A0A5F7ZLS2
names: Subcellular Location Annotation
messages: Nucleus

9544:PPP1R2
gene id: 9544:PPP1R2
uniprot id: F6T1H7
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9544:SEPHS1
gene id: 9544:SEPHS1
uniprot id: H9Z6J2
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9544:PPIB
gene id: 9544:PPIB
uniprot id: F7HFK5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9544:IL20
gene id: 9544:IL20
uniprot id: F7HHX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9544:MRPL1
gene id: 9544:MRPL1
uniprot id: F6UB30
names: Subcellular Location Annotation
messages: Mitochondrion

9544:PLEKHA8
gene id: 9544:PLEKHA8
uniprot id: H9Z3L8
names: Subcellular Location Annotation
messages: trans-Golgi network membrane

9544:IL2RB
gene id: 9544:IL2RB
uniprot id: H9Z8K1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.

9544:GJA1
gene id: 9544:GJA1
uniprot id: A0A8J8Y316
uniprot id: F7C314
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:MTF2
gene id: 9544:MTF2
uniprot id: F7GY59
uniprot id: H9Z6E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9544:CFB
gene id: 9544:CFB
uniprot id: F6YJY7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:MFNG
gene id: 9544:MFNG
uniprot id: A0A1D5QYG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:TBP
gene id: 9544:TBP
uniprot id: F6SEF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9544:UTY
gene id: 9544:UTY
uniprot id: A0A1D5QCV5
uniprot id: A0A1D5R9L3
uniprot id: A0A1D5RCG7
uniprot id: F7EHL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTX family.
messages: Nucleus

9544:ZNF768
gene id: 9544:ZNF768
uniprot id: H9FZV6
names: Subcellular Location Annotation
messages: Nucleus

9544:CWF19L2
gene id: 9544:CWF19L2
uniprot id: F6ZHQ6
names: Similarity
messages: Belongs to the CWF19 family.

9544:GABRD
gene id: 9544:GABRD
uniprot id: I2CYJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:ASCC3
gene id: 9544:ASCC3
uniprot id: F6X804
names: Similarity
messages: Belongs to the helicase family.

9544:RPF1
gene id: 9544:RPF1
uniprot id: F6XHR5
uniprot id: H9G022
names: Subcellular Location Annotation
messages: nucleolus

9544:USP10
gene id: 9544:USP10
uniprot id: H9YZC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:NSMCE2
gene id: 9544:NSMCE2
uniprot id: H9Z7Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

9544:NELL2
gene id: 9544:NELL2
uniprot id: A0A8J8YAC9
uniprot id: F7GWK3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:MRGBP
gene id: 9544:MRGBP
uniprot id: I0FT31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

9544:CTNNA2
gene id: 9544:CTNNA2
uniprot id: A0A8J8XFK0
uniprot id: F6YFG3
uniprot id: F7A9R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9544:DCP2
gene id: 9544:DCP2
uniprot id: A0A8J8YEL4
uniprot id: F7CI46
uniprot id: G7MVJ6
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9544:TIPARP
gene id: 9544:TIPARP
uniprot id: A0A8J8YF55
uniprot id: F6USD8
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:FFAR1
gene id: 9544:FFAR1
uniprot id: A0A8J8YKJ8
uniprot id: F6W3L4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:CENPL
gene id: 9544:CENPL
uniprot id: F6UIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9544:CLDN22
gene id: 9544:CLDN22
uniprot id: A0A8J8XTZ7
uniprot id: F6S639
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:LOC703455
gene id: 9544:LOC703455
uniprot id: A0A8J8Y2T8
uniprot id: F7HQ13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9544:TCP11L2
gene id: 9544:TCP11L2
uniprot id: F6S8U5
names: Similarity
messages: Belongs to the TCP11 family.

9544:COX7AH
gene id: 9544:COX7AH
uniprot id: Q53CF7
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9544:AWAT2
gene id: 9544:AWAT2
uniprot id: A0A8J8Y751
uniprot id: F7EZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9544:HRH4
gene id: 9544:HRH4
uniprot id: F6WWD4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:PARP2
gene id: 9544:PARP2
uniprot id: A0A5K1V1S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9544:SRP9
gene id: 9544:SRP9
uniprot id: A0A8J8XYF9
uniprot id: G7MEF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9544:RAB39A
gene id: 9544:RAB39A
uniprot id: A0A5F7ZUV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9544:SPRTN
gene id: 9544:SPRTN
uniprot id: H9ZE81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9544:PGPEP1
gene id: 9544:PGPEP1
uniprot id: A0A8J8Y1J7
uniprot id: F7GUB6
uniprot id: H9Z3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

9544:FIBIN
gene id: 9544:FIBIN
uniprot id: A0A8J8XPX0
uniprot id: F6X3Z2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9544:SFRP1
gene id: 9544:SFRP1
uniprot id: F6SGW3
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NAP1L4
gene id: 9544:NAP1L4
uniprot id: A0A5F8A9Q1
uniprot id: H9ERL2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9544:CLSTN2
gene id: 9544:CLSTN2
uniprot id: F7ENU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

9544:MED7
gene id: 9544:MED7
uniprot id: A0A8J8YBE8
uniprot id: F7GS62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9544:SHROOM4
gene id: 9544:SHROOM4
uniprot id: A0A1D5QPG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9544:LOC718737
gene id: 9544:LOC718737
uniprot id: F7HIX4
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9544:NLRP8
gene id: 9544:NLRP8
uniprot id: B0FNB1
names: Similarity
messages: Belongs to the NLRP family.

9544:CHD7
gene id: 9544:CHD7
uniprot id: F6PP91
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9544:IRF2BP2
gene id: 9544:IRF2BP2
uniprot id: H9Z8K7
uniprot id: H9Z8K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9544:PATZ1
gene id: 9544:PATZ1
uniprot id: H9FS89
names: Subcellular Location Annotation
messages: Nucleus

9544:NPPA
gene id: 9544:NPPA
uniprot id: F7CD36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9544:FEV
gene id: 9544:FEV
uniprot id: A0A5F7ZQN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:PPAN
gene id: 9544:PPAN
uniprot id: A0A8J8Y9T7
uniprot id: G7NKY9
names: Subcellular Location Annotation
messages: nucleolus

9544:GORASP1
gene id: 9544:GORASP1
uniprot id: A0A5K1UWY5
names: Similarity
messages: Belongs to the GORASP family.

9544:TFPI
gene id: 9544:TFPI
uniprot id: I0FUM5
uniprot id: Q28864
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
messages: O-glycosylated.
messages: Secreted
messages: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa (By similarity).

9544:FASN
gene id: 9544:FASN
uniprot id: A0A5K1UCR4
names: Function
messages: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

9544:CCDC25
gene id: 9544:CCDC25
uniprot id: H9FWM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9544:ARMCX3
gene id: 9544:ARMCX3
uniprot id: A0A8J8Y6H0
uniprot id: F6RKR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9544:PLA2G2D
gene id: 9544:PLA2G2D
uniprot id: A0A1D5Q074
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9544:IMPACT
gene id: 9544:IMPACT
uniprot id: F6RUS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

9544:INSL6
gene id: 9544:INSL6
uniprot id: A0A8J8YD75
uniprot id: F7G3C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9544:LIG3
gene id: 9544:LIG3
uniprot id: A0A8J8YG56
uniprot id: G7NGW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9544:DBT
gene id: 9544:DBT
uniprot id: A0A1D5R7T4
uniprot id: A0A8J8YSN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9544:IFI35
gene id: 9544:IFI35
uniprot id: I0FRE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9544:PHACTR4
gene id: 9544:PHACTR4
uniprot id: H9ZCM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

9544:PDGFD
gene id: 9544:PDGFD
uniprot id: I0FL09
uniprot id: I0FL10
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:HEXIM2
gene id: 9544:HEXIM2
uniprot id: A0A8J8YJX5
uniprot id: F6YS14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9544:E2F2
gene id: 9544:E2F2
uniprot id: F7H757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9544:TAS1R2
gene id: 9544:TAS1R2
uniprot id: A3QP01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
messages: Cell membrane
messages: Forms heterodimers with TAS1R3.
messages: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity).

9544:MT1E
gene id: 9544:MT1E
uniprot id: A0A8J8XCC6
uniprot id: F7ECS1
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9544:SEC61B
gene id: 9544:SEC61B
uniprot id: F7B5P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9544:PPP2R2C
gene id: 9544:PPP2R2C
uniprot id: F6Z2Q9
uniprot id: H9EMD0
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9544:SDC4
gene id: 9544:SDC4
uniprot id: A0A8J8XB75
uniprot id: I0FGX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9544:PSMA8
gene id: 9544:PSMA8
uniprot id: A0A1D5Q503
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9544:CXXC1
gene id: 9544:CXXC1
uniprot id: F7FBL1
uniprot id: I0FKC5
names: Subcellular Location Annotation
messages: Nucleus

9544:FCER1G
gene id: 9544:FCER1G
uniprot id: F6SD41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9544:LOC714964
gene id: 9544:LOC714964
uniprot id: B0Z9U9
uniprot id: V5NSD8
names: Similarity
messages: Belongs to the MHC class I family.

9544:ERGIC3
gene id: 9544:ERGIC3
uniprot id: A0A5K1TWI8
uniprot id: H9EQL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9544:TMEM38A
gene id: 9544:TMEM38A
uniprot id: H9FZN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9544:TERF2
gene id: 9544:TERF2
uniprot id: F6TW69
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9544:CLDN19
gene id: 9544:CLDN19
uniprot id: A0A8J8XNC2
uniprot id: F6YYW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:LANCL2
gene id: 9544:LANCL2
uniprot id: I0FTE5
names: Similarity
messages: Belongs to the LanC-like protein family.

9544:ZSCAN23
gene id: 9544:ZSCAN23
uniprot id: A0A8J8Y1Y8
uniprot id: F7EAK6
names: Subcellular Location Annotation
messages: Nucleus

9544:KEG06 p12
gene id: 9544:KEG06_p12
uniprot id: Q6IYH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9544:EDN1
gene id: 9544:EDN1
uniprot id: A0A8J8XEF4
uniprot id: F7FGG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9544:HTR5A
gene id: 9544:HTR5A
uniprot id: A0A8J8Y2W4
uniprot id: G7MNJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:MAPK8IP1
gene id: 9544:MAPK8IP1
uniprot id: A0A1D5Q0Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JIP scaffold family.
messages: Cytoplasm

9544:TAAR3
gene id: 9544:TAAR3
uniprot id: D2X5R0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:FXN
gene id: 9544:FXN
uniprot id: A0A1D5QYW7
names: Similarity
messages: Belongs to the frataxin family.

9544:CDK8
gene id: 9544:CDK8
uniprot id: H9FNK1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:UBN1
gene id: 9544:UBN1
uniprot id: A0A1D5QKW6
uniprot id: A0A8J8XH21
names: Similarity
messages: Belongs to the ubinuclein family.

9544:SASS6
gene id: 9544:SASS6
uniprot id: H9EVE5
names: Subcellular Location Annotation
messages: centrosome

9544:APOBEC3G
gene id: 9544:APOBEC3G
uniprot id: Q09GG0
uniprot id: Q09GH5
uniprot id: U5NDB3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm
messages: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.
messages: Homodimer.
messages: Nucleus
messages: P-body
messages: The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.

9544:PPDPF
gene id: 9544:PPDPF
uniprot id: F6W3F1
names: Similarity
messages: Belongs to the PPDPF family.

9544:LOC719903
gene id: 9544:LOC719903
uniprot id: F6YKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:KIF9
gene id: 9544:KIF9
uniprot id: G7MIR9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:STK3
gene id: 9544:STK3
uniprot id: H9FYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9544:NLGN3
gene id: 9544:NLGN3
uniprot id: A0A8J8XWA1
uniprot id: F6UBT7
uniprot id: G7NRV3
uniprot id: H9FML3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9544:ZNF445
gene id: 9544:ZNF445
uniprot id: H9Z8J6
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC2A3
gene id: 9544:SLC2A3
uniprot id: H9YVK0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9544:ATP4B
gene id: 9544:ATP4B
uniprot id: A0A5F8AP74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9544:PTGFR
gene id: 9544:PTGFR
uniprot id: A0A8J8XJB1
uniprot id: F7CGY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:ST6GALNAC3
gene id: 9544:ST6GALNAC3
uniprot id: A0A5K1VDB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:NOTCH1
gene id: 9544:NOTCH1
uniprot id: F7HQZ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9544:LOC100423855
gene id: 9544:LOC100423855
uniprot id: A0A1D5Q1X7
names: Similarity
messages: Belongs to the MS4A family.

9544:HIST1H2BK
gene id: 9544:HIST1H2BK
uniprot id: I0FVV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:OXSM
gene id: 9544:OXSM
uniprot id: F6W670
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9544:MDK
gene id: 9544:MDK
uniprot id: H9FUJ0
names: Similarity
messages: Belongs to the pleiotrophin family.

9544:LOC710748
gene id: 9544:LOC710748
uniprot id: A0A1D5QT04
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:ITM2A
gene id: 9544:ITM2A
uniprot id: A0A8J8XQH6
uniprot id: H9Z2C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9544:TIMP1
gene id: 9544:TIMP1
uniprot id: H9FZ30
uniprot id: Q95KL9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1 (By similarity).
messages: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).
messages: N-glycosylated.
messages: Secreted
messages: The activity of TIMP1 is dependent on the presence of disulfide bonds.

9544:MBLAC1
gene id: 9544:MBLAC1
uniprot id: A0A8J8YHQ0
uniprot id: G7MNT5
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9544:ADH1B
gene id: 9544:ADH1B
uniprot id: H9Z213
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9544:DLC1
gene id: 9544:DLC1
uniprot id: A0A1D5QFD0
names: Subcellular Location Annotation
messages: Cytoplasm

9544:NDUFC2
gene id: 9544:NDUFC2
uniprot id: A0A8J8Y4Z7
uniprot id: F7HK78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9544:ZNF496
gene id: 9544:ZNF496
uniprot id: F7BFX2
names: Subcellular Location Annotation
messages: Nucleus

9544:CBFB
gene id: 9544:CBFB
uniprot id: F7EFS7
uniprot id: H9G176
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

9544:SLITRK1
gene id: 9544:SLITRK1
uniprot id: A0A8J8YQQ4
uniprot id: F6S8N3
names: Similarity
messages: Belongs to the SLITRK family.

9544:SCAND1
gene id: 9544:SCAND1
uniprot id: G7N4Y2
names: Subcellular Location Annotation
messages: Nucleus

9544:TYROBP
gene id: 9544:TYROBP
uniprot id: A0A8J8XNR1
uniprot id: G7NMS6
uniprot id: Q8WNQ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity). Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity). Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (By similarity). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neuron…
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Following ligand binding by associated receptors, tyrosine phosphorylated in the ITAM domain which leads to activation of additional tyrosine kinases and subsequent cell activation.
messages: Homodimer; disulfide-linked (By similarity). Homotrimer; disulfide-linked (By similarity). Homotetramer; disulfide-linked (By similarity). Homotrimers and homotetramers form when low levels of partner receptors are available and is competitive with assembly with interacting receptors (By similarity). They may represent alternative oligomerization states or may be intermediates in the receptor assembly process (By similarity). Binding of a metal cation aids in homooligomerization through coordination of the metal ion by the subunits of the oligomer (By similarity). Interacts with TREM1 (By similarity). Interacts with TREM2 (By similarity). Interacts with CLECSF5 (By similarity). Interacts with CD300LB and CD300C2 (By similarity). Interacts with CD300E (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK mediating neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with KLRC2 (By similarity). Interacts with CD300H (By similarity). Interacts with KLRD1 (By similarity).
messages: Membrane

9544:PIWIL4
gene id: 9544:PIWIL4
uniprot id: E1AS11
names: Similarity
messages: Belongs to the argonaute family.

9544:GK5
gene id: 9544:GK5
uniprot id: H9Z7C5
names: Similarity
messages: Belongs to the FGGY kinase family.

9544:CAV2
gene id: 9544:CAV2
uniprot id: H9FN78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9544:A4GNT
gene id: 9544:A4GNT
uniprot id: A0A8J8XUA9
uniprot id: F6QQ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9544:RPE
gene id: 9544:RPE
uniprot id: H9YUF6
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9544:PRKCQ
gene id: 9544:PRKCQ
uniprot id: H9FX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9544:NGDN
gene id: 9544:NGDN
uniprot id: F7G0P4
names: Subcellular Location Annotation
messages: nucleolus

9544:MRPS25
gene id: 9544:MRPS25
uniprot id: A0A8J8XL50
uniprot id: H9Z3G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9544:TNRC6C
gene id: 9544:TNRC6C
uniprot id: H9FXR3
names: Similarity
messages: Belongs to the GW182 family.

9544:REV1
gene id: 9544:REV1
uniprot id: H9FVJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

9544:RPRD1A
gene id: 9544:RPRD1A
uniprot id: A0A8J8XN31
uniprot id: F6ZTW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

9544:LUC7L3
gene id: 9544:LUC7L3
uniprot id: A0A5F7ZXL8
uniprot id: A0A8J8XRC0
uniprot id: F7H6R2
uniprot id: H9ZA17
names: Similarity
messages: Belongs to the Luc7 family.

9544:ELP5
gene id: 9544:ELP5
uniprot id: F7CZW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9544:POLR3K
gene id: 9544:POLR3K
uniprot id: H9EUX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9544:DIO2
gene id: 9544:DIO2
uniprot id: H9FN65
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

9544:NTRK3
gene id: 9544:NTRK3
uniprot id: F7D0R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9544:RRM2
gene id: 9544:RRM2
uniprot id: F6WXL4
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9544:OS9
gene id: 9544:OS9
uniprot id: F6PTF4
uniprot id: F6PU01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9544:MED1
gene id: 9544:MED1
uniprot id: H9FW47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9544:ATP5MC2
gene id: 9544:ATP5MC2
uniprot id: F7GGY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9544:SERPINB12
gene id: 9544:SERPINB12
uniprot id: G7NKU4
names: Similarity
messages: Belongs to the serpin family.

9544:STUM
gene id: 9544:STUM
uniprot id: I2CYM1
names: Subcellular Location Annotation
messages: Membrane

9544:MGAT4A
gene id: 9544:MGAT4A
uniprot id: A0A8J8XA59
uniprot id: F6W7B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane

9544:BCAT2
gene id: 9544:BCAT2
uniprot id: I2CU61
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9544:STRN
gene id: 9544:STRN
uniprot id: F6YB92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9544:ALDH1L2
gene id: 9544:ALDH1L2
uniprot id: F6W9P8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9544:SAP30L
gene id: 9544:SAP30L
uniprot id: F7BKJ6
names: Similarity
messages: Belongs to the SAP30 family.

9544:TSPAN15
gene id: 9544:TSPAN15
uniprot id: A0A8J8Y8K4
uniprot id: F6Q657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:PTMA
gene id: 9544:PTMA
uniprot id: F7GZS2
uniprot id: I2CYA9
names: Similarity
messages: Belongs to the pro/parathymosin family.

9544:CYB5R1
gene id: 9544:CYB5R1
uniprot id: A0A8J8XK84
uniprot id: F7F187
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9544:RHBDD2
gene id: 9544:RHBDD2
uniprot id: A0A8J8XCQ4
uniprot id: G7MNZ0
names: Subcellular Location Annotation
messages: Membrane

9544:LAMB2
gene id: 9544:LAMB2
uniprot id: A0A8J8Y506
uniprot id: I0FRM8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9544:TMEM176B
gene id: 9544:TMEM176B
uniprot id: H9FTD1
uniprot id: H9FTD2
names: Similarity
messages: Belongs to the TMEM176 family.

9544:PROS1
gene id: 9544:PROS1
uniprot id: F6WG91
uniprot id: Q28520
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasma.
messages: Secreted
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

9544:MS4A4A
gene id: 9544:MS4A4A
uniprot id: F6TIS1
names: Similarity
messages: Belongs to the MS4A family.

9544:KCNQ4
gene id: 9544:KCNQ4
uniprot id: F7CRG2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:AKAP12
gene id: 9544:AKAP12
uniprot id: I0FWN1
names: Subcellular Location Annotation
messages: Membrane

9544:SEC22C
gene id: 9544:SEC22C
uniprot id: F7HRR1
uniprot id: F7HTH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9544:DENR
gene id: 9544:DENR
uniprot id: H9G148
names: Similarity
messages: Belongs to the DENR family.

9544:TMEM168
gene id: 9544:TMEM168
uniprot id: A0A8J8XHS0
uniprot id: F6RN04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane
messages: Nucleus membrane

9544:LSM8
gene id: 9544:LSM8
uniprot id: F7AG10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9544:JPT2
gene id: 9544:JPT2
uniprot id: F6SRV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9544:CAB39
gene id: 9544:CAB39
uniprot id: A0A8J8YTA7
uniprot id: F6Y0R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9544:CRKL
gene id: 9544:CRKL
uniprot id: A0A8J8Y1Q2
uniprot id: F6VK11
names: Similarity
messages: Belongs to the CRK family.

9544:ARHGDIA
gene id: 9544:ARHGDIA
uniprot id: F6VTL8
names: Similarity
messages: Belongs to the Rho GDI family.

9544:SLC15A3
gene id: 9544:SLC15A3
uniprot id: F7G7B5
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9544:CLPX
gene id: 9544:CLPX
uniprot id: A0A1D5RD00
names: Similarity
messages: Belongs to the ClpX chaperone family.

9544:NRG2
gene id: 9544:NRG2
uniprot id: F6T2G3
uniprot id: F6T2Z6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:PPP1R14D
gene id: 9544:PPP1R14D
uniprot id: F7GNA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Inhibitor of PPP1CA.
messages: Membrane

9544:MSMP
gene id: 9544:MSMP
uniprot id: A0A8J8XW17
uniprot id: F7HL15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9544:GNRH1
gene id: 9544:GNRH1
uniprot id: A0A8J8YIX6
uniprot id: G7N0Q8
uniprot id: P55247
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
messages: The precursor is cleaved by ACE, which removes the Gly-Lys-Arg peptide at the C-terminus, leading to mature hormone. The mature form of Gonadoliberin-1 is also cleaved and degraded by ACE.

9544:TAF8
gene id: 9544:TAF8
uniprot id: H9FPX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9544:ENTPD5
gene id: 9544:ENTPD5
uniprot id: F7ANV4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9544:SLC35F1
gene id: 9544:SLC35F1
uniprot id: F6ZBR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9544:MYADM
gene id: 9544:MYADM
uniprot id: A0A8J8Y9Y0
uniprot id: G7NN51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9544:OIP5
gene id: 9544:OIP5
uniprot id: A0A8J8XU99
uniprot id: F7E2E5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9544:LGSN
gene id: 9544:LGSN
uniprot id: G7MPN9
names: Similarity
messages: Belongs to the glutamine synthetase family.

9544:THEMIS2
gene id: 9544:THEMIS2
uniprot id: A0A8J8Y5X0
uniprot id: F7EYF7
names: Similarity
messages: Belongs to the themis family.

9544:RAP2A
gene id: 9544:RAP2A
uniprot id: F7GCR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9544:BTF3
gene id: 9544:BTF3
uniprot id: G7MQL9
uniprot id: I0FHT3
names: Similarity
messages: Belongs to the NAC-beta family.

9544:BLOC1S1
gene id: 9544:BLOC1S1
uniprot id: H9Z1H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space

9544:MEGF8
gene id: 9544:MEGF8
uniprot id: A0A1D5Q5S1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:GRPR
gene id: 9544:GRPR
uniprot id: F7HCY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CPEB4
gene id: 9544:CPEB4
uniprot id: A0A1D5R7M6
uniprot id: A0A5F7ZM15
uniprot id: A0A8J8YKD7
uniprot id: G7MU03
uniprot id: H9G045
names: Similarity
messages: Belongs to the RRM CPEB family.

9544:HACD1
gene id: 9544:HACD1
uniprot id: F7GVB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:ENO1
gene id: 9544:ENO1
uniprot id: A0A5F7ZL29
uniprot id: A0A5F8A477
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9544:PON1
gene id: 9544:PON1
uniprot id: A0A8J8YIF5
uniprot id: F7H7J8
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9544:SARAF
gene id: 9544:SARAF
uniprot id: A0A8J8XII5
uniprot id: F7BVH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9544:APP
gene id: 9544:APP
uniprot id: A0A8J8XRV9
uniprot id: F7CLL9
uniprot id: G7MNB1
uniprot id: I0FGN2
uniprot id: I0FGN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Secreted
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9544:CACNB1
gene id: 9544:CACNB1
uniprot id: F7A9T0
uniprot id: F7HBW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Membrane
messages: sarcolemma

9544:TMCC2
gene id: 9544:TMCC2
uniprot id: A0A8J8YTC8
uniprot id: F7BGZ1
uniprot id: F7GNP4
names: Similarity
messages: Belongs to the TEX28 family.

9544:LOC106997918
gene id: 9544:LOC106997918
uniprot id: F7GZH5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9544:TOM1
gene id: 9544:TOM1
uniprot id: I0FGD9
names: Similarity
messages: Belongs to the TOM1 family.

9544:RBKS
gene id: 9544:RBKS
uniprot id: F7BAI3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9544:NLRP9
gene id: 9544:NLRP9
uniprot id: B0FNA9
names: Similarity
messages: Belongs to the NLRP family.

9544:TMEM170A
gene id: 9544:TMEM170A
uniprot id: A0A8J8XFN2
uniprot id: F7G4T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9544:RPS15A
gene id: 9544:RPS15A
uniprot id: I2CW01
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

9544:POLE2
gene id: 9544:POLE2
uniprot id: F6ZV13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

9544:CALB1
gene id: 9544:CALB1
uniprot id: A0A8J8YPV8
uniprot id: G7MZQ9
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

9544:TAS2R39
gene id: 9544:TAS2R39
uniprot id: Q645S5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

9544:TECR
gene id: 9544:TECR
uniprot id: H9Z0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:OR6M1
gene id: 9544:OR6M1
uniprot id: F6X8S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9544:TMEM134
gene id: 9544:TMEM134
uniprot id: F7FYP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

9544:ACE
gene id: 9544:ACE
uniprot id: A0A1D5R9B8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 2 Zn(2+) ions per subunit.

9544:CYP2R1
gene id: 9544:CYP2R1
uniprot id: F6XN90
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:DLX3
gene id: 9544:DLX3
uniprot id: A0A8J8XGF2
uniprot id: F7HLW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9544:PTGR2
gene id: 9544:PTGR2
uniprot id: A0A5F8ATW2
uniprot id: A0A8J8XW06
uniprot id: G7MYM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9544:SERP2
gene id: 9544:SERP2
uniprot id: A0A1D5RKH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9544:RBM42
gene id: 9544:RBM42
uniprot id: A0A8J8XNZ5
uniprot id: F6YCY8
uniprot id: F6YD35
names: Similarity
messages: Belongs to the RRM RBM42 family.

9544:BPIFC
gene id: 9544:BPIFC
uniprot id: A0A8J8XMC2
uniprot id: F7HFH9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9544:PQLC3
gene id: 9544:PQLC3
uniprot id: G7NBA7
names: Subcellular Location Annotation
messages: Membrane

9544:FNTA
gene id: 9544:FNTA
uniprot id: I0FQC8
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9544:ATP6V1D
gene id: 9544:ATP6V1D
uniprot id: A0A8J8Y835
uniprot id: F7EFE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9544:LOC100429959
gene id: 9544:LOC100429959
uniprot id: G7ND93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:MRPL52
gene id: 9544:MRPL52
uniprot id: A0A5K1UY78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9544:OLFM3
gene id: 9544:OLFM3
uniprot id: A0A8J8Y6U0
uniprot id: F7H3M5
uniprot id: F7HKM5
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9544:WNT2
gene id: 9544:WNT2
uniprot id: A0A8J8XPN3
uniprot id: F7E738
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:CCR9
gene id: 9544:CCR9
uniprot id: A0A8J8XHJ5
uniprot id: F7HFQ4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:GSTA3
gene id: 9544:GSTA3
uniprot id: A0A5F7ZPN2
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9544:PIM2
gene id: 9544:PIM2
uniprot id: A0A8J8XD14
uniprot id: F6S4X1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9544:SDHC
gene id: 9544:SDHC
uniprot id: G7MEA1
uniprot id: I2CTM5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9544:ADSS
gene id: 9544:ADSS
uniprot id: F7HTL0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9544:MANEA
gene id: 9544:MANEA
uniprot id: F6VNN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:SH3BP4
gene id: 9544:SH3BP4
uniprot id: F6T6Y1
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9544:CUL3
gene id: 9544:CUL3
uniprot id: F6R900
uniprot id: G7N924
names: Similarity
messages: Belongs to the cullin family.

9544:EBF1
gene id: 9544:EBF1
uniprot id: A0A1D5R8G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9544:RNASE4
gene id: 9544:RNASE4
uniprot id: A0A8J8YRC3
uniprot id: W0UVA6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9544:MUL1
gene id: 9544:MUL1
uniprot id: F7EZL0
names: Subcellular Location Annotation
messages: Membrane

9544:METTL14
gene id: 9544:METTL14
uniprot id: A0A8J8XV69
uniprot id: G7MRV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.

9544:COQ8A
gene id: 9544:COQ8A
uniprot id: A0A8J8Y436
uniprot id: F7F8M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane

9544:PM20D2
gene id: 9544:PM20D2
uniprot id: F6TN77
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.

9544:APOC2
gene id: 9544:APOC2
uniprot id: A0A8J8XRV4
uniprot id: G7NMB2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.
messages: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
messages: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
messages: Secreted

9544:CDH9
gene id: 9544:CDH9
uniprot id: F7GUW1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:NAT1
gene id: 9544:NAT1
uniprot id: A0A8J8Y431
uniprot id: F6Q3X1
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9544:TNF
gene id: 9544:TNF
uniprot id: A0A8J8YGV5
uniprot id: G7MRI3
uniprot id: P48094
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity).
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9544:VCL
gene id: 9544:VCL
uniprot id: F7F2A5
uniprot id: F7HSL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: podosome

9544:CCR3
gene id: 9544:CCR3
uniprot id: Q7JH47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:F3
gene id: 9544:F3
uniprot id: H9FR67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9544:PNPLA4
gene id: 9544:PNPLA4
uniprot id: A0A5F7ZD64
uniprot id: F7E9K3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:APIP
gene id: 9544:APIP
uniprot id: A0A5K1VIZ5
uniprot id: F7HS49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9544:RNF10
gene id: 9544:RNF10
uniprot id: A0A5F7ZSB5
uniprot id: H9ERI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

9544:CRAT
gene id: 9544:CRAT
uniprot id: F7HQL4
uniprot id: I0FJJ0
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9544:GPBP1L1
gene id: 9544:GPBP1L1
uniprot id: A0A8J8XN46
uniprot id: F6VH41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9544:POU4F2
gene id: 9544:POU4F2
uniprot id: A0A8J8XPW6
uniprot id: F7F4M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9544:CFL2
gene id: 9544:CFL2
uniprot id: A0A8J8YS11
uniprot id: G7MXF7
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9544:GALNT17
gene id: 9544:GALNT17
uniprot id: F6Y9A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9544:ITGA3
gene id: 9544:ITGA3
uniprot id: A0A5F7ZAZ7
uniprot id: F7HLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9544:KHDC1L
gene id: 9544:KHDC1L
uniprot id: A0A8J8XLF8
uniprot id: G7MPQ2
names: Similarity
messages: Belongs to the KHDC1 family.

9544:PDE8A
gene id: 9544:PDE8A
uniprot id: F7FU86
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:PABPC1L
gene id: 9544:PABPC1L
uniprot id: F6XFC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9544:KDM1A
gene id: 9544:KDM1A
uniprot id: F6ZH68
uniprot id: I2CUD3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

9544:TRUB1
gene id: 9544:TRUB1
uniprot id: H9FQ80
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9544:RTN1
gene id: 9544:RTN1
uniprot id: F7HG96
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ICAM3
gene id: 9544:ICAM3
uniprot id: Q5NKT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9544:UQCRQ
gene id: 9544:UQCRQ
uniprot id: A0A8J8XNU9
uniprot id: F6RLW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9544:LPIN1
gene id: 9544:LPIN1
uniprot id: A0A1D5QEP2
names: Similarity
messages: Belongs to the lipin family.

9544:ACSM3
gene id: 9544:ACSM3
uniprot id: A0A5F8AL21
uniprot id: A0A8J8YD25
uniprot id: F7APW8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:XKRX
gene id: 9544:XKRX
uniprot id: A0A8J8XTN1
uniprot id: F6YLV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9544:BEX2
gene id: 9544:BEX2
uniprot id: A0A5F8AUH3
uniprot id: F6XD12
names: Similarity
messages: Belongs to the BEX family.

9544:GABRA6
gene id: 9544:GABRA6
uniprot id: G7MVU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:ROGDI
gene id: 9544:ROGDI
uniprot id: F7EM13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Presynapse
messages: Vesicle
messages: synaptic vesicle

9544:CEP44
gene id: 9544:CEP44
uniprot id: H9ZDW7
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9544:DYRK1B
gene id: 9544:DYRK1B
uniprot id: A0A5F8AAW5
uniprot id: F7GIB1
uniprot id: H9G1R0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9544:GADD45B
gene id: 9544:GADD45B
uniprot id: A0A8J8XRF0
uniprot id: F7EBI6
names: Similarity
messages: Belongs to the GADD45 family.

9544:ATRNL1
gene id: 9544:ATRNL1
uniprot id: A0A1D5RK70
uniprot id: F7FWX9
uniprot id: F7FWY3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:LOC715687
gene id: 9544:LOC715687
uniprot id: H9EUT1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

9544:PICK1
gene id: 9544:PICK1
uniprot id: H9G232
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9544:FITM1
gene id: 9544:FITM1
uniprot id: A0A8J8YLF0
uniprot id: G7MX59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

9544:SORD
gene id: 9544:SORD
uniprot id: A0A8J8Y0H6
uniprot id: F6XVN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 1 or 2 Zn(2+) ions per subunit.
messages: Homotetramer.
messages: Mitochondrion membrane
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
messages: flagellum

9544:MITF
gene id: 9544:MITF
uniprot id: A0A8J8YDF0
uniprot id: H9ELZ8
uniprot id: H9FUK9
uniprot id: I2CV82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9544:MMP3
gene id: 9544:MMP3
uniprot id: F6YVN6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9544:AKR1E2
gene id: 9544:AKR1E2
uniprot id: F7HGX6
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9544:ESYT1
gene id: 9544:ESYT1
uniprot id: A0A1D5QPB7
uniprot id: H9EVG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CDSN
gene id: 9544:CDSN
uniprot id: Q5TM45
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9544:FGF6
gene id: 9544:FGF6
uniprot id: A0A5F7ZSU6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:CCN5
gene id: 9544:CCN5
uniprot id: G7N4S0
names: Similarity
messages: Belongs to the CCN family.

9544:SMC1A
gene id: 9544:SMC1A
uniprot id: A0A8J8YSA0
uniprot id: G7NRH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9544:GPT
gene id: 9544:GPT
uniprot id: F6TEF9
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9544:GLRA1
gene id: 9544:GLRA1
uniprot id: A0A5K1V9F3
uniprot id: F7GTN8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

9544:VPS35
gene id: 9544:VPS35
uniprot id: I0FFY6
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9544:SNAPIN
gene id: 9544:SNAPIN
uniprot id: A0A8J8XE56
uniprot id: F7HGD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9544:RIOK2
gene id: 9544:RIOK2
uniprot id: A0A5F7ZE42
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9544:IL1B
gene id: 9544:IL1B
uniprot id: P48090
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling. Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form. Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC. Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9544:SAP18
gene id: 9544:SAP18
uniprot id: F7CXR4
names: Similarity
messages: Belongs to the SAP18 family.

9544:TMOD2
gene id: 9544:TMOD2
uniprot id: A0A8J8XYE0
uniprot id: F7HPP2
names: Subcellular Location Annotation
messages: cytoskeleton

9544:SLC12A5
gene id: 9544:SLC12A5
uniprot id: H9EUB3
uniprot id: I2CUQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9544:GRK3
gene id: 9544:GRK3
uniprot id: H9FQI6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9544:HOOK1
gene id: 9544:HOOK1
uniprot id: F7A7W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9544:VWA2
gene id: 9544:VWA2
uniprot id: A0A5F8ALK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CSNK1A1L
gene id: 9544:CSNK1A1L
uniprot id: A0A8J8YKA8
uniprot id: F7AM42
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:BZW2
gene id: 9544:BZW2
uniprot id: A0A8J8XN68
uniprot id: F7HNR9
names: Similarity
messages: Belongs to the BZW family.

9544:NKAP
gene id: 9544:NKAP
uniprot id: H9ZDI2
names: Similarity
messages: Belongs to the NKAP family.

9544:ZC3H12B
gene id: 9544:ZC3H12B
uniprot id: F6UZL1
names: Similarity
messages: Belongs to the ZC3H12 family.

9544:ATP6AP2
gene id: 9544:ATP6AP2
uniprot id: A0A8J8YGK3
uniprot id: F7BK83
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9544:CERS3
gene id: 9544:CERS3
uniprot id: A0A8J8XGB9
uniprot id: F7G3X0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9544:AP4M1
gene id: 9544:AP4M1
uniprot id: F7DJN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
messages: Early endosome
messages: trans-Golgi network membrane

9544:SSTR3
gene id: 9544:SSTR3
uniprot id: F6XSK8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:SPTBN1
gene id: 9544:SPTBN1
uniprot id: F7FS44
uniprot id: H9YXU8
uniprot id: I0FIZ4
names: Similarity
messages: Belongs to the spectrin family.

9544:IGF2BP2
gene id: 9544:IGF2BP2
uniprot id: F7F9B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9544:TRMT1
gene id: 9544:TRMT1
uniprot id: F6RHR7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

9544:CMC1
gene id: 9544:CMC1
uniprot id: H9FQG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9544:PDE4B
gene id: 9544:PDE4B
uniprot id: A0A1D5R2V8
uniprot id: A0A8J8Y9Y9
uniprot id: F6QKH9
uniprot id: F6QKI6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9544:ZFHX4
gene id: 9544:ZFHX4
uniprot id: F6RGC8
names: Subcellular Location Annotation
messages: Nucleus

9544:KITLG
gene id: 9544:KITLG
uniprot id: A0A5F7ZFV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

9544:MAMU-DOA
gene id: 9544:MAMU-DOA
uniprot id: A0A5F7ZL43
uniprot id: A0A5F8ADY2
uniprot id: G8F1Z2
names: Similarity
messages: Belongs to the MHC class II family.

9544:RPS13
gene id: 9544:RPS13
uniprot id: F6Y9M4
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9544:NLGN4X
gene id: 9544:NLGN4X
uniprot id: F7CFI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9544:TUBG1
gene id: 9544:TUBG1
uniprot id: A0A8J8Y401
uniprot id: G7NIM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9544:KCNJ11
gene id: 9544:KCNJ11
uniprot id: A0A8J8XTN9
uniprot id: F7HFY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9544:NDFIP2
gene id: 9544:NDFIP2
uniprot id: F6QC75
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9544:RGS7BP
gene id: 9544:RGS7BP
uniprot id: A0A8J8XGB0
uniprot id: G7MU59
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9544:PTPN14
gene id: 9544:PTPN14
uniprot id: G7MEK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9544:SIX2
gene id: 9544:SIX2
uniprot id: A0A8J8YNT7
uniprot id: F7HAN3
uniprot id: G7N9Z8
names: Subcellular Location Annotation
messages: Nucleus

9544:CLK4
gene id: 9544:CLK4
uniprot id: A0A1D5RIS4
uniprot id: A0A8J8XAT3
uniprot id: F7GB49
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:INTU
gene id: 9544:INTU
uniprot id: F6VUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

9544:CCDC172
gene id: 9544:CCDC172
uniprot id: F6W0U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

9544:GLRA3
gene id: 9544:GLRA3
uniprot id: A0A1D5RJX7
uniprot id: A0A8J8YB66
uniprot id: F7DY62
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9544:KCNV2
gene id: 9544:KCNV2
uniprot id: A0A5F8AIT9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:LOC720791
gene id: 9544:LOC720791
uniprot id: A0A8J8XLR1
uniprot id: F7CA88
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

9544:PADI2
gene id: 9544:PADI2
uniprot id: A0A8J8Y6A6
uniprot id: G7MH55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9544:POLR2D
gene id: 9544:POLR2D
uniprot id: A0A8J8YJY5
uniprot id: F6V9J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

9544:KCNQ2
gene id: 9544:KCNQ2
uniprot id: F7ASA7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:TMPO
gene id: 9544:TMPO
uniprot id: A0A1D5Q2B0
uniprot id: F7HAU0
uniprot id: F7HAV4
uniprot id: H9FZ48
names: Similarity
messages: Belongs to the LEM family.

9544:DOHH
gene id: 9544:DOHH
uniprot id: A0A5F8AHZ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

9544:CAMK2A
gene id: 9544:CAMK2A
uniprot id: H9EMI1
uniprot id: H9EMI2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9544:HIST1H2BO
gene id: 9544:HIST1H2BO
uniprot id: A0A5F8AKB8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:TNKS
gene id: 9544:TNKS
uniprot id: A0A8J8XKK4
uniprot id: F6QQJ9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:LOC717598
gene id: 9544:LOC717598
uniprot id: A0A8J8XYP4
uniprot id: F6TP71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:STMN1
gene id: 9544:STMN1
uniprot id: A0A5F7ZEB3
uniprot id: I0FRN2
names: Similarity
messages: Belongs to the stathmin family.

9544:KCNH2
gene id: 9544:KCNH2
uniprot id: F6WED3
names: Subcellular Location Annotation
messages: Membrane

9544:FGF17
gene id: 9544:FGF17
uniprot id: A0A7U3JW27
uniprot id: A0A8J8Y5D6
uniprot id: G7N0M4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:CCL23
gene id: 9544:CCL23
uniprot id: Q8HYP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted
messages: Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1 (By similarity).

9544:RNASE9
gene id: 9544:RNASE9
uniprot id: D1YSI5
uniprot id: W0UVD8
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9544:NKX2-4
gene id: 9544:NKX2-4
uniprot id: F6VYJ7
names: Subcellular Location Annotation
messages: Nucleus

9544:TRIM35
gene id: 9544:TRIM35
uniprot id: F6STB1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:TNRC6B
gene id: 9544:TNRC6B
uniprot id: F6XNN3
names: Similarity
messages: Belongs to the GW182 family.

9544:HIST1H2AD
gene id: 9544:HIST1H2AD
uniprot id: A0A8J8XQP2
uniprot id: G7MR32
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:PGC
gene id: 9544:PGC
uniprot id: A0A8J8Y3J1
uniprot id: G7MPA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted

9544:ALDH2
gene id: 9544:ALDH2
uniprot id: A0A5K1TZ33
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9544:HIST1H2AC
gene id: 9544:HIST1H2AC
uniprot id: A0A8J8YN90
uniprot id: F7HAP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:ASMT
gene id: 9544:ASMT
uniprot id: Q8HZJ0
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
messages: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
messages: Highly expressed in pineal gland. In the retina, 10- to 100-fold lower expression compared to pineal gland, if any.
messages: Homodimer.
messages: No night/day variations.

9544:CORO2A
gene id: 9544:CORO2A
uniprot id: G7NEY8
names: Similarity
messages: Belongs to the WD repeat coronin family.

9544:GJA5
gene id: 9544:GJA5
uniprot id: A0A8J8XQH8
uniprot id: F7GSB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:AFG1L
gene id: 9544:AFG1L
uniprot id: G7MQY9
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9544:PPIL3
gene id: 9544:PPIL3
uniprot id: H9ERV3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9544:INKA2
gene id: 9544:INKA2
uniprot id: A0A5F8AFS3
uniprot id: A0A8J8YCN7
uniprot id: G7MIH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9544:CACNA2D1
gene id: 9544:CACNA2D1
uniprot id: A0A1D5QVR4
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9544:CHRNA7
gene id: 9544:CHRNA7
uniprot id: Q866A2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin (By similarity).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-7/CHRNA7 sub-subfamily.
messages: Cell membrane
messages: Glycosylations at Asn-46, Asn-90 and Asn-133 are essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to the cell membrane.
messages: Homopentamer. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6. Interacts with the alpha-conotoxin RgIA. Interacts with alpha-conotoxins ImI and ImII (By similarity). Interacts with CANX (By similarity).
messages: Postsynaptic cell membrane

9544:CBX6
gene id: 9544:CBX6
uniprot id: A0A1D5QQQ4
names: Subcellular Location Annotation
messages: Nucleus

9544:DCTN2
gene id: 9544:DCTN2
uniprot id: F6UW67
uniprot id: H9FNS4
uniprot id: H9FNS5
names: Similarity
messages: Belongs to the dynactin subunit 2 family.

9544:NR0B1
gene id: 9544:NR0B1
uniprot id: A0A8J8YMH7
uniprot id: F7EIG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9544:TOR4A
gene id: 9544:TOR4A
uniprot id: F7C872
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9544:DUSP12
gene id: 9544:DUSP12
uniprot id: A0A5F8ALM7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9544:AP3S2
gene id: 9544:AP3S2
uniprot id: A0A8J8XNK2
uniprot id: G7MVX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9544:ARL6
gene id: 9544:ARL6
uniprot id: A0A5F7ZYN6
uniprot id: F7EGS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9544:FAM163A
gene id: 9544:FAM163A
uniprot id: A0A8J8YIK1
uniprot id: F6XKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9544:DDR1
gene id: 9544:DDR1
uniprot id: F6Y731
uniprot id: Q5TM72
names: Subcellular Location Annotation
messages: Membrane

9544:LPGAT1
gene id: 9544:LPGAT1
uniprot id: G7MEM3
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9544:OR4D9
gene id: 9544:OR4D9
uniprot id: A0A5F8ALW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PPP3CB
gene id: 9544:PPP3CB
uniprot id: F6SFC6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9544:IRF2BP1
gene id: 9544:IRF2BP1
uniprot id: F7CH05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9544:RNASE2
gene id: 9544:RNASE2
uniprot id: A0A8J8Y3K6
uniprot id: F7CXW8
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9544:UPK1B
gene id: 9544:UPK1B
uniprot id: A0A1D5RG23
uniprot id: A0A8J8XMS0
names: Subcellular Location Annotation
messages: Membrane

9544:LOC100423831
gene id: 9544:LOC100423831
uniprot id: F7D8P5
names: Similarity
messages: Belongs to the LCE family.

9544:DDB1
gene id: 9544:DDB1
uniprot id: A0A8J8XXB3
uniprot id: G7ND21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9544:GNB4
gene id: 9544:GNB4
uniprot id: A0A8J8XL79
uniprot id: F6ZIZ9
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9544:LDB3
gene id: 9544:LDB3
uniprot id: F6QFV3
names: Subcellular Location Annotation
messages: Z line

9544:JPH3
gene id: 9544:JPH3
uniprot id: H9FXK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9544:EIF3G
gene id: 9544:EIF3G
uniprot id: F7HE98
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9544:IRF3
gene id: 9544:IRF3
uniprot id: B6CJX6
names: Subcellular Location Annotation
messages: Nucleus

9544:MANBAL
gene id: 9544:MANBAL
uniprot id: A0A8J8XZF6
uniprot id: F7E8Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9544:SIKE1
gene id: 9544:SIKE1
uniprot id: A0A8J8XJ33
uniprot id: F7H9W4
uniprot id: H9G023
names: Similarity
messages: Belongs to the SIKE family.

9544:URM1
gene id: 9544:URM1
uniprot id: I0FVD5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9544:CBWD1
gene id: 9544:CBWD1
uniprot id: H9FUN5
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9544:NFASC
gene id: 9544:NFASC
uniprot id: A0A5F7ZF69
uniprot id: A0A5F7ZL73
uniprot id: A0A5F8A926
uniprot id: F6UVX7
uniprot id: F6V3D0
uniprot id: F6V3E9
uniprot id: F6V3K6
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9544:LPAR6
gene id: 9544:LPAR6
uniprot id: F7AZM0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:EIF4E3
gene id: 9544:EIF4E3
uniprot id: H9EPE4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9544:MRPS36
gene id: 9544:MRPS36
uniprot id: H9YXX5
names: Subcellular Location Annotation
messages: Mitochondrion

9544:NPB
gene id: 9544:NPB
uniprot id: F6S922
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

9544:LOC704104
gene id: 9544:LOC704104
uniprot id: A0A8J8Y3X7
uniprot id: F7FLX7
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:MTMR8
gene id: 9544:MTMR8
uniprot id: F6ZSQ9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9544:NDUFAF2
gene id: 9544:NDUFAF2
uniprot id: A0A8J8XRE5
uniprot id: G7MTT6
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9544:ELOF1
gene id: 9544:ELOF1
uniprot id: A0A8J8XBH3
uniprot id: H9ZED7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9544:TAS2R7
gene id: 9544:TAS2R7
uniprot id: G7N657
uniprot id: Q645T7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
messages: Membrane
messages: Several bitter taste receptors are expressed in a single taste receptor cell.

9544:PCMT1
gene id: 9544:PCMT1
uniprot id: F7GFV2
uniprot id: F7GFV8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9544:PELP1
gene id: 9544:PELP1
uniprot id: Q1W1Y5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIX1/PELP1 family.
messages: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1.
messages: Cytoplasm
messages: Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3. Interacts with PI3K, SRC and EGFR in cytoplasm. Interacts with ESR1, the interaction is enhanced by 17-beta-estradiol; the interaction increases ESR1 transcriptional activity (By similarity). Interacts with CREBBP and EP300 in a ligand-dependent manner (By similarity). Forms two complexes in the presence of 17-beta-estradiol; one with SRC and ESR1 and another with LCK and ESR1. Interacts with histone H1 and H3 with a greater affinity for H1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Core component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Interacts with BCAS3. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts (via PELP1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus
messages: The Glu-rich region mediates histones interaction.
messages: The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1.
messages: Transiently sumoylated, preferentially conjugated to SUMO2 or SUMO3. Sumoylation causes nucleolar exclusion of PELP1 and promotes the recruitment of MDN1 to pre-60S particles. Desumoylation by SUMO isopeptidase SENP3 is needed to release both PELP1 and MDN1 from pre-ribosomes.
messages: nucleolus
messages: nucleoplasm

9544:ACRBP
gene id: 9544:ACRBP
uniprot id: A0A1D5QLM1
uniprot id: A0A8J8Y1G7
names: Subcellular Location Annotation
messages: acrosome

9544:LOC702827
gene id: 9544:LOC702827
uniprot id: A0A1D5RJP8
names: Similarity
messages: Belongs to the ATG8 family.

9544:LRRC8E
gene id: 9544:LRRC8E
uniprot id: A0A8J8YRA5
uniprot id: F7GRN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9544:EXOSC9
gene id: 9544:EXOSC9
uniprot id: H9FVZ0
names: Subcellular Location Annotation
messages: Cytoplasm

9544:TMEM256
gene id: 9544:TMEM256
uniprot id: F6SZ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9544:ARL2
gene id: 9544:ARL2
uniprot id: H9ESA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9544:HDX
gene id: 9544:HDX
uniprot id: A0A8J8YCE8
uniprot id: F7D8D4
names: Subcellular Location Annotation
messages: Nucleus

9544:GABARAP
gene id: 9544:GABARAP
uniprot id: F6U6S1
names: Similarity
messages: Belongs to the ATG8 family.

9544:UBE2A
gene id: 9544:UBE2A
uniprot id: H9FZA1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:ATG101
gene id: 9544:ATG101
uniprot id: A0A8J8XXG0
uniprot id: F7HI77
names: Similarity
messages: Belongs to the ATG101 family.

9544:OPTN
gene id: 9544:OPTN
uniprot id: H9FNG7
uniprot id: Q861Q8
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.
messages: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
messages: Present in aqueous humor of the eye (at protein level).
messages: Recycling endosome
messages: Self-associates (By similarity). Interacts with HD, GTF3A, TRAF3, TBK1 and MYO6. Interacts (via UBAN) with ubiquitinated TFRC. Interacts with active GTP-bound Rab8 (RAB8A and/or RAB8B). Interacts with TBC1D17. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increases the association (at least with MAP1LC3B). Interacts with RAB12; the interaction may be indirect (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction does not lead to palmitoylation of OPTN (By similarity). Interacts with CYLD (By similarity). Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and OPTN (By similarity).
messages: The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.
messages: Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9544:ATP6V0B
gene id: 9544:ATP6V0B
uniprot id: H9ZA59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9544:SRY
gene id: 9544:SRY
uniprot id: Q9BG90
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of Lys-136 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3.
messages: Belongs to the SRY family.
messages: Cytoplasm
messages: Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its DNA-binding activity. The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form. Interaction with PARP1 impaired its DNA-binding activity.
messages: Nucleus
messages: Nucleus speckle
messages: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).

9544:SPOPL
gene id: 9544:SPOPL
uniprot id: A0A8J8Y024
uniprot id: F7HSR0
names: Similarity
messages: Belongs to the Tdpoz family.

9544:KIF3A
gene id: 9544:KIF3A
uniprot id: F7HNX9
uniprot id: H9FPA5
uniprot id: I2CTD3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:ESS2
gene id: 9544:ESS2
uniprot id: A0A1D5QU64
uniprot id: A0A8J8XL60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9544:MOB1B
gene id: 9544:MOB1B
uniprot id: G7MT47
uniprot id: H9G1U8
names: Similarity
messages: Belongs to the MOB1/phocein family.

9544:DNTTIP2
gene id: 9544:DNTTIP2
uniprot id: A0A1D5Q3I4
uniprot id: F7H033
names: Subcellular Location Annotation
messages: nucleolus

9544:TMEM126A
gene id: 9544:TMEM126A
uniprot id: A0A8J8YBA9
uniprot id: F6W686
names: Subcellular Location Annotation
messages: Membrane

9544:NLRP3
gene id: 9544:NLRP3
uniprot id: B0FPE9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NLRP family.
messages: Degraded via selective autophagy following interaction with IRGM. IRGM promotes NLRP3 recruitment to autophagosome membranes, promoting its SQSTM1/p62-dependent autophagy-dependent degradation.
messages: Endoplasmic reticulum
messages: Golgi apparatus membrane
messages: Highly expressed in oocyte, testis, spleen, thymus and kidney.
messages: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth. During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF.
messages: Inflammasome
messages: Mitochondrion
messages: Nucleus
messages: Palmitoylation by ZDHHC12 inhibits the NLRP3 inflammasome by promoting NLRP3 degradation by the chaperone-mediated autophagy pathway. Following palmitoylation, HSPA8/HSC70 recognizes and binds the KFERQ-like motifs on NLRP3 and promotes NLRP3 recruitment to lysosomes, where it is degraded via the chaperone-mediated autophagy pathway in a LAMP2-dependent process.
messages: Phosphorylation at Ser-198 by MAPK8/JNK1 increases inflammasome activation by promoting deubiquitination by BRCC3 and NLRP3 homooligomerization. Phosphorylation at Ser-805 by CSNK1A1 prevents inflammasome activation by preventing NEK7 recruitment. Phosphorylation at Ser-5 in the pyrin domain inhibits homomultimerization of NLRP3 and activation of the NLRP3 inflammasome: dephosphorylation by protein phosphatase 2A (PP2A) promotes assembly of the NLRP3 inflammasome (By similarity). Phosphorylation at Ser-295 by PKD/PRKD1 promotes NLRP3 inflammasome assembly (By similarity). Phosphorylation by ERK1/MAPK3 promotes NLRP3 inflammasome assembly. Phosphorylation by BTK (at Tyr-136, Tyr-140, Tyr-143 and Tyr-168) in the region that mediates binding to phosphatidylinositol phosphate, promotes relocalization of NLRP3 and assembly of the NLRP3 inflammasome. Phosphorylation at Tyr-860 inhibits NLRP3 inflammasome assembly: dephosphorylation by PTPN22 promotes inflammasome activation (By similarity).
messages: Secreted
messages: Sensor component of NLRP3 inflammasomes; inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation. The core of NLRP3 inflammasomes consists of a signal sensor component (NLRP3), an adapter (PYCARD/ASC), which recruits an effector pro-inflammatory caspase (CASP1 and, possibly, CASP4 and CASP5). Homodecamer; inactive NLRP3 forms homodecameric double-ring cages that hide pyrin domains within NACHT-LRR rings to avoid premature activation. Interacts (via pyrin domain) with PYCARD/ASC (via pyrin domain); interaction is direct. Interacts (via LRR repeat domain) with NEK7 (via N-terminus); the interaction is required for the formation of the complex NLRP3:PYCARD, oligomerization of PYCARD/ASC and activation of CASP1 (By similarity). Interacts (via LRR repeat domain) with NR4A1/Nur77 (via N-terminus); the interaction is direct, requires activation of NR4A1 by its ligands NBRE-containing dsDNA and lipopolysaccharide, and stimulates the association of NLRP3 with NEK7 for non-canonical NLRP3 inflammasome activation (By similarity). Interacts with CARD8; leading to inhibit formation of the NLRP3 inflammasome. Interacts with MEFV; this interaction targets NLRP3 to degradation by autophagy, hence preventing excessive IL1B- and IL18-mediated inflammation (By similarity). Interacts with EIF2AK2/PKR; this interaction requires EIF2AK2 activity, is accompanied by EIF2AK2 autophosphorylation and promotes inflammasome assembly in response to specific stimuli (By similarity). Interacts with GBP5 (via DAPIN domain); this interaction promotes inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Interacts with PML (isoform PML-1) (via the leucine-rich repeat (LRR) domain); PML-mediated increase in NLRP3 inflammasome activation does not depend upon this interaction. Interacts (via NACHT domain) with DHX33 (via DEAH box); NL…
messages: Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis. In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC. Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis. Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (By similarity). Under resting conditions, ADP-bound NLRP3 is autoinhibited (By similarity). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc. Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex. Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P). Shows ATPase activity (By similarity).
messages: The FISNA domain is a critical mediator of NLRP3 conformational during NLRP3 activation. It becomes ordered in its key regions during activation to stabilize the active NACHT conformation and mediate most interactions in the NLRP3 disk.
messages: The KFERQ-like motifs mediate binding to HSPA8/HSC70 following NLRP3 paylmitoylation by ZDHHC12.
messages: The LRR domain mediates the interaction with IRF4, PML, NEK7 and NR4A1/Nur77.
messages: The disulfide bond in the pyrin domain might play a role in reactive oxygen species-mediated activation.
messages: The pyrin domain (also called DAPIN domain or PYD) is involved in PYCARD/ASC-binding.
messages: Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination (By similarity). Ubiquitination does not lead to degradation, but inhibits inflammasome activation. Deubiquitination is catalyzed by BRCC3 and associated with NLRP3 activation and inflammasome assembly. This process can be induced by the activation of Toll-like receptors (by LPS), through a non-transcriptional pathway dependent on the mitochondrial production of reactive oxygen species, and by ATP (By similarity). Ubiquitinated by TRIM31 via 'Lys-48'-linked ubiquitination, leading to its degradation by the proteasome. Ubiquitinated at Lys-689 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (By similarity). Ubiquitinated by TRIM35 via 'lys-48' and 'Lys-63'-linked ubiquitination leading to inhibition of NLRP3 inflammasome activation (By similarity).
messages: Under resting conditions, NLRP3 binds ADP and is autoinhibited (By similarity). Inactive NLRP3 forms homodecameric double-ring cages that hide pyrin domains within NACHT-LRR rings to avoid premature activation. NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc. Almost all stimuli trigger intracellular K(+) efflux. These stimuli lead to membrane perturbations that induce activation of NLRP3. Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and recruitment of PYCARD/ASC for the formation of an active inflammasome complex. NEK7-activated NLRP3 forms a disk-shaped inflammasome. NLRP3 and PYCARD/ASC interact via their respective pyrin domains; interaction initiates speck formation (nucleation) which greatly enhances further addition of soluble PYCARD/ASC molecules to the speck in a prion-like polymerization process (By similarity). Clustered PYCARD/ASC nucleates the formation of CASP1 filaments through the interaction of their respective CARD domains, acting as a platform for CASP1 polymerization and activation. Active CASP1 then processes IL1B and IL18 precursors, leading to the release of mature cytokines in the extracellular milieu and inflammatory response (By similarity). NLRP3 inflammasome assembly is inhibited by IRGM, which impedes NLRP3 oligomerization (By similarity). Specifically inhibited by sulfonylurea MCC950 (also named CP-456,773, CRID3), a potent and specific small-molecule inhibitor of the NLRP3 inflammasome that acts by preventing ATP hydrolysis (By similarity).
messages: cytosol
messages: microtubule organizing center

9544:PIK3IP1
gene id: 9544:PIK3IP1
uniprot id: A0A5F8ADS8
uniprot id: F7CNM1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:TGFB2
gene id: 9544:TGFB2
uniprot id: A0A8J8XS43
uniprot id: F6ZJW6
uniprot id: F6ZJX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9544:LEPR
gene id: 9544:LEPR
uniprot id: F7DIP7
uniprot id: Q9MYL0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3.
messages: Membrane
messages: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-984 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1139 is required for STAT3 binding/activation (By similarity).
messages: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-984 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1139 is required for STAT3 binding/activation. Phosphorylation of Tyr-1077 has a more accessory role.
messages: Present as a mixture of monomers and dimers. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (By similarity).
messages: Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.
messages: Widely expressed. High expression of isoform B in liver, adipose tissue, hypothalamus and choroid plexus.

9544:VPS28
gene id: 9544:VPS28
uniprot id: F6X3L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
messages: Membrane

9544:PRRT1
gene id: 9544:PRRT1
uniprot id: F6UY02
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9544:GLIPR1
gene id: 9544:GLIPR1
uniprot id: F6YQN5
names: Similarity
messages: Belongs to the CRISP family.

9544:METTL26
gene id: 9544:METTL26
uniprot id: H9G0Q7
names: Similarity
messages: Belongs to the UPF0585 family.

9544:EVA1B
gene id: 9544:EVA1B
uniprot id: I0FT16
names: Similarity
messages: Belongs to the EVA1 family.

9544:VIPAS39
gene id: 9544:VIPAS39
uniprot id: A0A8J8XF23
uniprot id: G7MYW8
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9544:GTDC1
gene id: 9544:GTDC1
uniprot id: H9EX90
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

9544:KCNJ3
gene id: 9544:KCNJ3
uniprot id: A0A8J8YRF5
uniprot id: F7ERG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9544:DDC
gene id: 9544:DDC
uniprot id: A0A8J8YGT9
uniprot id: F7FNW6
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9544:NLRP2
gene id: 9544:NLRP2
uniprot id: B0FPF0
names: Similarity
messages: Belongs to the NLRP family.

9544:DAPK2
gene id: 9544:DAPK2
uniprot id: A0A5F8A5R6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:USP29
gene id: 9544:USP29
uniprot id: F7HA66
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9544:SATB2
gene id: 9544:SATB2
uniprot id: H9EQF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9544:SUPV3L1
gene id: 9544:SUPV3L1
uniprot id: I0FUK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9544:UCHL1
gene id: 9544:UCHL1
uniprot id: I0FK06
names: Similarity
messages: Belongs to the peptidase C12 family.

9544:SLC2A2
gene id: 9544:SLC2A2
uniprot id: F6U5N3
uniprot id: F7CLP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9544:SHMT1
gene id: 9544:SHMT1
uniprot id: F7FV99
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9544:ARHGEF3
gene id: 9544:ARHGEF3
uniprot id: A0A8J8XYH0
uniprot id: G7ML13
uniprot id: H9FV28
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9544:ESRRB
gene id: 9544:ESRRB
uniprot id: F7DBF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9544:ALDH1L1
gene id: 9544:ALDH1L1
uniprot id: A0A1D5QNH6
uniprot id: A0A8J8YPK4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9544:ZNF711
gene id: 9544:ZNF711
uniprot id: A0A8J8XXM1
uniprot id: G7NSD8
uniprot id: H9EMP3
names: Subcellular Location Annotation
messages: Nucleus

9544:FAM168A
gene id: 9544:FAM168A
uniprot id: A0A8J8Y980
uniprot id: F7EPI2
uniprot id: H9END5
names: Similarity
messages: Belongs to the FAM168 family.

9544:STX11
gene id: 9544:STX11
uniprot id: A0A8J8XC03
uniprot id: G7MQ70
names: Similarity
messages: Belongs to the syntaxin family.

9544:ADPRH
gene id: 9544:ADPRH
uniprot id: F6REF0
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9544:CYP2D6
gene id: 9544:CYP2D6
uniprot id: Q6GUQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:RAB9A
gene id: 9544:RAB9A
uniprot id: A0A8J8XA93
uniprot id: F6Z6I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9544:INSRR
gene id: 9544:INSRR
uniprot id: A0A5F7ZFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9544:CCN2
gene id: 9544:CCN2
uniprot id: H9FQD5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:LOC100423381
gene id: 9544:LOC100423381
uniprot id: A0A5F8ALR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:GRHL2
gene id: 9544:GRHL2
uniprot id: F7HKR5
names: Subcellular Location Annotation
messages: Nucleus

9544:HACL1
gene id: 9544:HACL1
uniprot id: F6YNW6
names: Similarity
messages: Belongs to the TPP enzyme family.

9544:PBX1
gene id: 9544:PBX1
uniprot id: F6WM30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9544:NARF
gene id: 9544:NARF
uniprot id: F6TW76
names: Similarity
messages: Belongs to the NARF family.

9544:MRI1
gene id: 9544:MRI1
uniprot id: A0A8J8Y6Q1
uniprot id: G7NLY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

9544:TLR10
gene id: 9544:TLR10
uniprot id: A0A8J8Y4H9
uniprot id: B3Y674
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9544:IWS1
gene id: 9544:IWS1
uniprot id: A0A5K1VQ97
uniprot id: G7NB48
names: Subcellular Location Annotation
messages: Nucleus

9544:PTPN12
gene id: 9544:PTPN12
uniprot id: A0A1D5RIQ8
uniprot id: F7EGH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

9544:LOC703363
gene id: 9544:LOC703363
uniprot id: A0A5F7ZGD1
names: Similarity
messages: Belongs to the GAGE family.

9544:CYP19A1
gene id: 9544:CYP19A1
uniprot id: A0A1D5QZ23
uniprot id: A0A8J8XT54
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:GIPC3
gene id: 9544:GIPC3
uniprot id: F6VZG8
names: Similarity
messages: Belongs to the GIPC family.

9544:LOC711174
gene id: 9544:LOC711174
uniprot id: A0A8J8XY78
uniprot id: F7GNB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9544:AP1M2
gene id: 9544:AP1M2
uniprot id: G7NL08
uniprot id: H9H4V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9544:RAB32
gene id: 9544:RAB32
uniprot id: F7H6R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9544:TRMT61A
gene id: 9544:TRMT61A
uniprot id: F7D5Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9544:GYS1
gene id: 9544:GYS1
uniprot id: Q8MJ26
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does (By similarity).
messages: Belongs to the glycosyltransferase 3 family.
messages: Interacts with GYG1.
messages: Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (By similarity).
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9544:SLC25A2
gene id: 9544:SLC25A2
uniprot id: A0A8J8YN11
uniprot id: F6T3V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:KCNK5
gene id: 9544:KCNK5
uniprot id: G7MP84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9544:POLR1C
gene id: 9544:POLR1C
uniprot id: A0A8J8Y886
uniprot id: G7MPF0
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9544:DTD1
gene id: 9544:DTD1
uniprot id: F6SFP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

9544:N4BP3
gene id: 9544:N4BP3
uniprot id: F6WBA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Vesicle
messages: dendrite

9544:TBX15
gene id: 9544:TBX15
uniprot id: F7H8C3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9544:KIF1C
gene id: 9544:KIF1C
uniprot id: H9FNY6
uniprot id: I2CWB9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9544:ISL2
gene id: 9544:ISL2
uniprot id: A0A5F7ZE39
names: Subcellular Location Annotation
messages: Nucleus

9544:GATAD1
gene id: 9544:GATAD1
uniprot id: I0FTS7
names: Subcellular Location Annotation
messages: Nucleus

9544:MOS
gene id: 9544:MOS
uniprot id: A0A8J8XB45
uniprot id: F6VV07
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:NDFIP1
gene id: 9544:NDFIP1
uniprot id: F7D4X8
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9544:MAB21L1
gene id: 9544:MAB21L1
uniprot id: A0A8J8XAK6
uniprot id: F7GRJ0
names: Similarity
messages: Belongs to the mab-21 family.

9544:TECRL
gene id: 9544:TECRL
uniprot id: A0A1D5QYG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9544:ORC5
gene id: 9544:ORC5
uniprot id: A0A8J8XC17
uniprot id: H9ETN3
names: Subcellular Location Annotation
messages: Nucleus

9544:BTBD10
gene id: 9544:BTBD10
uniprot id: A0A5F8AH43
uniprot id: A0A8J8Y6J4
uniprot id: F6Y3M8
uniprot id: I0FVN1
names: Subcellular Location Annotation
messages: Cytoplasm

9544:DGUOK
gene id: 9544:DGUOK
uniprot id: F7DR19
uniprot id: F7DR32
names: Similarity
messages: Belongs to the DCK/DGK family.

9544:MCM5
gene id: 9544:MCM5
uniprot id: F6QKN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9544:TPRA1
gene id: 9544:TPRA1
uniprot id: A0A5F7Z7Q2
uniprot id: A0A5F8ADR2
uniprot id: F6RK37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9544:ANXA10
gene id: 9544:ANXA10
uniprot id: A0A1D5Q3F4
names: Similarity
messages: Belongs to the annexin family.

9544:ACTN1
gene id: 9544:ACTN1
uniprot id: A0A1D5QE04
uniprot id: H9YUP4
uniprot id: I0FW14
names: Similarity
messages: Belongs to the alpha-actinin family.

9544:SPC25
gene id: 9544:SPC25
uniprot id: F6SZE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9544:EGR2
gene id: 9544:EGR2
uniprot id: A0A8J8XBH1
uniprot id: G7N2E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9544:LOC701966
gene id: 9544:LOC701966
uniprot id: A0A5F7ZKR0
uniprot id: G7MZ60
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9544:HOXA6
gene id: 9544:HOXA6
uniprot id: F6YGT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9544:LAD1
gene id: 9544:LAD1
uniprot id: A0A1D5QW47
names: Function
names: Subcellular Location Annotation
messages: Anchoring filament protein which is a component of the basement membrane zone.
messages: basement membrane

9544:SLC13A5
gene id: 9544:SLC13A5
uniprot id: A0A8J8XTJ0
uniprot id: G0X6X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9544:MTG1
gene id: 9544:MTG1
uniprot id: H9G1T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Mitochondrion inner membrane
messages: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

9544:RXFP2
gene id: 9544:RXFP2
uniprot id: D3JXK7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:ANKH
gene id: 9544:ANKH
uniprot id: F6T3T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9544:TOMM7
gene id: 9544:TOMM7
uniprot id: I0FKS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9544:NAA35
gene id: 9544:NAA35
uniprot id: F7FX53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9544:OVOL3
gene id: 9544:OVOL3
uniprot id: F7A428
names: Subcellular Location Annotation
messages: Nucleus

9544:TAZ
gene id: 9544:TAZ
uniprot id: F7FYK4
uniprot id: Q6IV77
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function (By similarity). Its role in cellular physiology is to improve mitochondrial performance (By similarity). RCL is critical for the coassembly of lipids and proteins in mitochondrial membranes, for instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity). Catalyzes the transacylation between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL. Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate. Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor. CoA-independent, it can reshuffle molecular species within a single phospholipid class. Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL. Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, …
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane
messages: The HXXXXD motif is essential for acyltransferase activity.
messages: The enzyme was named after a masochistic character Tafazzi, once popular on Italian television, apparently due to the difficulty encountered for its identification and characterization.

9544:ZC3HC1
gene id: 9544:ZC3HC1
uniprot id: F6PNL5
names: Subcellular Location Annotation
messages: Nucleus

9544:BORCS8
gene id: 9544:BORCS8
uniprot id: A0A1D5R9Y5
uniprot id: A0A8J8YC29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9544:ENTPD4
gene id: 9544:ENTPD4
uniprot id: H9F039
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9544:HOXD9
gene id: 9544:HOXD9
uniprot id: A0A1D5QBX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9544:RUNDC3A
gene id: 9544:RUNDC3A
uniprot id: A0A5F8AB47
names: Similarity
messages: Belongs to the RUNDC3 family.

9544:EAF2
gene id: 9544:EAF2
uniprot id: F6QNE7
names: Similarity
messages: Belongs to the EAF family.

9544:MAU2
gene id: 9544:MAU2
uniprot id: A0A5K1VIB2
uniprot id: F7EW52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9544:BZW1
gene id: 9544:BZW1
uniprot id: A0A5F8A311
uniprot id: F6ZFX8
names: Similarity
messages: Belongs to the BZW family.

9544:TMEM138
gene id: 9544:TMEM138
uniprot id: A0A5F7ZUX0
uniprot id: A0A8J8YRH7
uniprot id: F6Z4N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9544:LOC693887
gene id: 9544:LOC693887
uniprot id: A0A8J8Y3X7
uniprot id: F7FLX7
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:ETS2
gene id: 9544:ETS2
uniprot id: A0A8J8XIC2
uniprot id: G7MMS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcription factor.

9544:SLC26A10
gene id: 9544:SLC26A10
uniprot id: A0A5F7ZPD7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:CA14
gene id: 9544:CA14
uniprot id: H9EWN2
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9544:PPM1K
gene id: 9544:PPM1K
uniprot id: F6RY71
uniprot id: G8F1F4
names: Similarity
messages: Belongs to the PP2C family.

9544:CDR2L
gene id: 9544:CDR2L
uniprot id: H9ER67
names: Similarity
messages: Belongs to the CDR2 family.

9544:ASB16
gene id: 9544:ASB16
uniprot id: F7BVZ8
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:MRPL50
gene id: 9544:MRPL50
uniprot id: A0A5F8A6B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9544:USP15
gene id: 9544:USP15
uniprot id: A0A5F8AGG6
uniprot id: F6QY38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9544:SPOCK2
gene id: 9544:SPOCK2
uniprot id: F6UWN5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:GSTK1
gene id: 9544:GSTK1
uniprot id: I0FRI5
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9544:INIP
gene id: 9544:INIP
uniprot id: A0A8J8XBN8
uniprot id: G7NEH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9544:LOC710527
gene id: 9544:LOC710527
uniprot id: F7ARE6
uniprot id: F7ARF7
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9544:NPAS4
gene id: 9544:NPAS4
uniprot id: F6XNH5
names: Subcellular Location Annotation
messages: Nucleus

9544:HTATSF1
gene id: 9544:HTATSF1
uniprot id: A0A8J8XPK0
uniprot id: F7HDT6
names: Similarity
messages: Belongs to the HTATSF1 family.

9544:PDHB
gene id: 9544:PDHB
uniprot id: F6R4J1
uniprot id: G8F1Q0
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9544:NMNAT2
gene id: 9544:NMNAT2
uniprot id: A0A8J8YEU3
uniprot id: F7BCS0
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9544:PGLS
gene id: 9544:PGLS
uniprot id: H9FSJ0
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

9544:FAM168B
gene id: 9544:FAM168B
uniprot id: A0A8J8YQ58
uniprot id: G7NB68
names: Similarity
messages: Belongs to the FAM168 family.

9544:SIN3A
gene id: 9544:SIN3A
uniprot id: F7H3V1
names: Subcellular Location Annotation
messages: Nucleus

9544:VEZT
gene id: 9544:VEZT
uniprot id: A0A8J8XEM0
uniprot id: F7A020
uniprot id: H9FWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9544:ARMCX1
gene id: 9544:ARMCX1
uniprot id: F7HDD4
uniprot id: G8F1Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9544:CXCL13
gene id: 9544:CXCL13
uniprot id: A0A8J8XAP4
uniprot id: Q8HYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9544:TPMT
gene id: 9544:TPMT
uniprot id: F6TPF9
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Monomer.

9544:DNAJA1
gene id: 9544:DNAJA1
uniprot id: F7C2X2
names: Subcellular Location Annotation
messages: Membrane

9544:ADAMTS15
gene id: 9544:ADAMTS15
uniprot id: F7FFL7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9544:TMEM229B
gene id: 9544:TMEM229B
uniprot id: A0A8J8XSK5
uniprot id: F7FXH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9544:GRM7
gene id: 9544:GRM7
uniprot id: F6WXJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9544:GPR18
gene id: 9544:GPR18
uniprot id: F7FDS5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:NPY5R
gene id: 9544:NPY5R
uniprot id: A0A8J8YSI7
uniprot id: Q9GK73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

9544:C19H19orf25
gene id: 9544:C19H19orf25
uniprot id: H9FQC3
names: Similarity
messages: Belongs to the UPF0449 family.

9544:AGAP2
gene id: 9544:AGAP2
uniprot id: I2CTW2
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9544:RORC
gene id: 9544:RORC
uniprot id: H9ZC29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9544:CNFN
gene id: 9544:CNFN
uniprot id: A0A8J8YJ77
uniprot id: G7NLL8
names: Similarity
messages: Belongs to the cornifelin family.

9544:CDH18
gene id: 9544:CDH18
uniprot id: A0A8J8XSY9
uniprot id: F7FMS7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9544:NHS
gene id: 9544:NHS
uniprot id: F6S8A2
uniprot id: F7CLI9
names: Similarity
messages: Belongs to the NHS family.

9544:FAM216B
gene id: 9544:FAM216B
uniprot id: F6TNU8
names: Similarity
messages: Belongs to the FAM216 family.

9544:CLTRN
gene id: 9544:CLTRN
uniprot id: A0A8J8XSN0
uniprot id: F7AH22
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:SLC25A19
gene id: 9544:SLC25A19
uniprot id: A0A8J8XBP0
uniprot id: G7NGP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:LCN15
gene id: 9544:LCN15
uniprot id: A0A8J8XII7
uniprot id: F6QQQ8
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9544:GLG1
gene id: 9544:GLG1
uniprot id: A0A1D5Q1M7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

9544:SLC6A1
gene id: 9544:SLC6A1
uniprot id: F6WVM8
uniprot id: G8F1M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9544:RNF185
gene id: 9544:RNF185
uniprot id: A0A8J8XEE9
uniprot id: G7N3M6
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9544:GUCY1B1
gene id: 9544:GUCY1B1
uniprot id: A0A1D5QWW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9544:SLC35E2B
gene id: 9544:SLC35E2B
uniprot id: A0A5K1VRI8
uniprot id: F7G9G7
names: Subcellular Location Annotation
messages: Membrane

9544:PTGS1
gene id: 9544:PTGS1
uniprot id: F6S984
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:RDM1
gene id: 9544:RDM1
uniprot id: F7FCQ6
uniprot id: F7HK94
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9544:TNFRSF4
gene id: 9544:TNFRSF4
uniprot id: A0A5F7ZEC3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:CA13
gene id: 9544:CA13
uniprot id: A0A1D5QB60
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9544:HOXD1
gene id: 9544:HOXD1
uniprot id: A0A5F8AUH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9544:CANT1
gene id: 9544:CANT1
uniprot id: A0A8J8XXX3
uniprot id: G7NH10
names: Similarity
messages: Belongs to the apyrase family.

9544:FOXB2
gene id: 9544:FOXB2
uniprot id: F7DF65
names: Subcellular Location Annotation
messages: Nucleus

9544:TRIP13
gene id: 9544:TRIP13
uniprot id: F7G4N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Nucleus
messages: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.
messages: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis.

9544:SFPQ
gene id: 9544:SFPQ
uniprot id: F6SSM0
names: Subcellular Location Annotation
messages: Nucleus speckle

9544:CAMSAP2
gene id: 9544:CAMSAP2
uniprot id: A0A8J8XKB0
uniprot id: F6VME1
uniprot id: F6VME9
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9544:WNT7B
gene id: 9544:WNT7B
uniprot id: F7HJM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:POGLUT3
gene id: 9544:POGLUT3
uniprot id: A0A5F7ZLV7
names: Similarity
messages: Belongs to the KDELC family.

9544:NOSTRIN
gene id: 9544:NOSTRIN
uniprot id: A0A8J8XHN0
uniprot id: F7FT19
names: Subcellular Location Annotation
messages: cytoskeleton

9544:YEATS4
gene id: 9544:YEATS4
uniprot id: A0A8J8XRA9
uniprot id: G7N7M0
names: Subcellular Location Annotation
messages: Nucleus

9544:TRIM9
gene id: 9544:TRIM9
uniprot id: A0A1D5Q2P9
uniprot id: F7GMP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

9544:PEA15
gene id: 9544:PEA15
uniprot id: I0FW10
names: Subcellular Location Annotation
messages: Cytoplasm

9544:OSBPL2
gene id: 9544:OSBPL2
uniprot id: A0A8J8Y6F3
uniprot id: G7N498
uniprot id: H9ERR8
names: Similarity
messages: Belongs to the OSBP family.

9544:RAB39B
gene id: 9544:RAB39B
uniprot id: A0A8J8XIE4
uniprot id: F6WUS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9544:MDC1
gene id: 9544:MDC1
uniprot id: Q5TM68
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Homodimer. Interacts with several proteins involved in the DNA damage response, although not all these interactions may be direct. Interacts with H2AX, which requires phosphorylation of H2AX. Interacts with the MRN complex, composed of MRE11, RAD50, and NBN. Interacts with CHEK2, which requires ATM-mediated phosphorylation within the FHA domain of CHEK2. Interacts constitutively with the BRCA1-BARD1 complex, SMC1A and TP53BP1. Interacts with ATM and FANCD2, and these interactions are reduced upon DNA damage. Also interacts with the PRKDC complex, composed of XRCC6/KU70, XRCC5/KU80 and PRKDC/XRCC7. This interaction may be required for PRKDC autophosphorylation, which is essential for DNA double strand break (DSB) repair. When phosphorylated by ATM, interacts with RNF8 (via FHA domain). Interacts with CEP164. When phosphorylated, interacts with APTX (via FHA-like domain) (By similarity).
messages: Nucleus
messages: Phosphorylated upon exposure to ionizing radiation (IR), ultraviolet radiation (UV), and hydroxyurea (HU). Phosphorylation in response to IR requires ATM, NBN, and possibly CHEK2. Also phosphorylated during the G2/M phase of the cell cycle and during activation of the mitotic spindle checkpoint. Phosphorylation at Thr-4 by ATM stabilizes and enhances homodimerization via the FHA domain (By similarity).
messages: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity).
messages: Sumoylation at Lys-1924 by PIAS4 following DNA damage promotes ubiquitin-mediated degradation.
messages: Tandemly repeated BRCT domains are characteristic of proteins involved in DNA damage signaling. In MDC1, these repeats are required for localization to chromatin which flanks sites of DNA damage marked by 'Ser-139' phosphorylation of H2AX (By similarity).
messages: Ubiquitinated by RNF4, leading to proteasomal degradation; undergoes 'Lys-48'-linked polyubiquitination.

9544:PKP4
gene id: 9544:PKP4
uniprot id: F6PTU9
uniprot id: F6PTY4
uniprot id: I0FVU7
names: Similarity
messages: Belongs to the beta-catenin family.

9544:TPD52
gene id: 9544:TPD52
uniprot id: A0A5F7ZU92
uniprot id: A0A5F8AQW7
uniprot id: G7MZM0
uniprot id: I0FLD4
names: Similarity
messages: Belongs to the TPD52 family.

9544:VPS13D
gene id: 9544:VPS13D
uniprot id: H9FWK4
names: Similarity
messages: Belongs to the VPS13 family.

9544:ACAP3
gene id: 9544:ACAP3
uniprot id: I0FP30
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9544:TRIM45
gene id: 9544:TRIM45
uniprot id: A0A8J8YDC6
uniprot id: G7MFZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9544:ADCY5
gene id: 9544:ADCY5
uniprot id: A0A1D5QWQ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Membrane

9544:MYH2
gene id: 9544:MYH2
uniprot id: F6UHN4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:MEMO1
gene id: 9544:MEMO1
uniprot id: H9EQ09
names: Similarity
messages: Belongs to the MEMO1 family.

9544:MAP3K7
gene id: 9544:MAP3K7
uniprot id: F7H6S1
uniprot id: F7H6S6
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9544:HLX
gene id: 9544:HLX
uniprot id: A0A5F8ANL9
names: Subcellular Location Annotation
messages: Nucleus

9544:IRF4
gene id: 9544:IRF4
uniprot id: F7A8U1
uniprot id: H9Z8N1
names: Subcellular Location Annotation
messages: Nucleus

9544:DPYSL5
gene id: 9544:DPYSL5
uniprot id: F6XU97
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9544:VDAC1
gene id: 9544:VDAC1
uniprot id: H9Z018
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9544:TSPAN17
gene id: 9544:TSPAN17
uniprot id: I0FQS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:YWHAZ
gene id: 9544:YWHAZ
uniprot id: A0A8J8XBY4
uniprot id: F7HBD4
names: Similarity
messages: Belongs to the 14-3-3 family.

9544:HNMT
gene id: 9544:HNMT
uniprot id: A0A5F7ZTE0
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9544:IMPG2
gene id: 9544:IMPG2
uniprot id: F6WFP4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

9544:CDADC1
gene id: 9544:CDADC1
uniprot id: F6ZM52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm

9544:HAX1
gene id: 9544:HAX1
uniprot id: H9FNR0
uniprot id: I0FNF9
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

9544:RUNX1
gene id: 9544:RUNX1
uniprot id: F6PP34
uniprot id: H9YWG8
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9544:SAMD8
gene id: 9544:SAMD8
uniprot id: H9EP29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9544:DEFB122
gene id: 9544:DEFB122
uniprot id: G7N559
uniprot id: Q5J5Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9544:KRT17
gene id: 9544:KRT17
uniprot id: F6YK97
names: Similarity
messages: Belongs to the intermediate filament family.

9544:GRK1
gene id: 9544:GRK1
uniprot id: G7NJP2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9544:CCBE1
gene id: 9544:CCBE1
uniprot id: F7D3T0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:SLC41A1
gene id: 9544:SLC41A1
uniprot id: A0A8J8XIJ2
uniprot id: F7EEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9544:TM9SF1
gene id: 9544:TM9SF1
uniprot id: A0A8J8XZZ1
uniprot id: G7MX66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9544:PLAUR
gene id: 9544:PLAUR
uniprot id: F6Q0B8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:DUSP1
gene id: 9544:DUSP1
uniprot id: A0A8J8Y5G1
uniprot id: F7ES52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9544:SEPTIN5
gene id: 9544:SEPTIN5
uniprot id: I0FSR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9544:RHO
gene id: 9544:RHO
uniprot id: A0A8J8YFX4
uniprot id: F7ETG0
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane

9544:SESN2
gene id: 9544:SESN2
uniprot id: F7FNU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9544:NAA10
gene id: 9544:NAA10
uniprot id: F7GKG6
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9544:MS4A7
gene id: 9544:MS4A7
uniprot id: F6QJM7
names: Similarity
messages: Belongs to the MS4A family.

9544:TMEM175
gene id: 9544:TMEM175
uniprot id: A0A5F8AKN0
uniprot id: F7HE41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

9544:PPP2R5C
gene id: 9544:PPP2R5C
uniprot id: A0A5K1VS24
uniprot id: F7ANY1
uniprot id: H9FWN6
uniprot id: I0FIN3
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9544:EXOG
gene id: 9544:EXOG
uniprot id: A0A5F8ALR3
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9544:RDH16
gene id: 9544:RDH16
uniprot id: A0A1D5QPG1
uniprot id: A0A8J8Y9G0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:CAMK2G
gene id: 9544:CAMK2G
uniprot id: A0A1D5RJS6
uniprot id: F7FD86
uniprot id: H9G0A0
uniprot id: H9G0A1
uniprot id: H9G0A2
uniprot id: H9G0A3
uniprot id: H9G0A4
uniprot id: I2CY34
uniprot id: I2CYW5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9544:AKR1B1
gene id: 9544:AKR1B1
uniprot id: A0A8J8XER5
uniprot id: G7MME8
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9544:TCTN2
gene id: 9544:TCTN2
uniprot id: I0FMS5
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9544:TAS2R46
gene id: 9544:TAS2R46
uniprot id: Q645T4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
messages: cilium membrane

9544:LPAR2
gene id: 9544:LPAR2
uniprot id: A0A8J8XTX1
uniprot id: F6WZP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:BCL2L13
gene id: 9544:BCL2L13
uniprot id: A0A8J8XX42
uniprot id: G7N374
names: Similarity
messages: Belongs to the Bcl-2 family.

9544:MRPL28
gene id: 9544:MRPL28
uniprot id: F6Y8S5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

9544:PRCP
gene id: 9544:PRCP
uniprot id: I0FJ27
names: Similarity
messages: Belongs to the peptidase S28 family.

9544:PITPNM1
gene id: 9544:PITPNM1
uniprot id: F7H788
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9544:GABRR1
gene id: 9544:GABRR1
uniprot id: F6W0N4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:NUS1
gene id: 9544:NUS1
uniprot id: F7DI78
names: Similarity
messages: Belongs to the UPP synthase family.

9544:SLC39A2
gene id: 9544:SLC39A2
uniprot id: A0A8J8XA69
uniprot id: F7EPA1
names: Subcellular Location Annotation
messages: Membrane

9544:OR7D4
gene id: 9544:OR7D4
uniprot id: D1MFA1
names: Subcellular Location Annotation
messages: Membrane

9544:GTF2IRD1
gene id: 9544:GTF2IRD1
uniprot id: I2CV09
names: Subcellular Location Annotation
messages: Nucleus

9544:HSBP1
gene id: 9544:HSBP1
uniprot id: A0A8J8XNC7
uniprot id: F7GKB4
names: Similarity
messages: Belongs to the HSBP1 family.

9544:SF1
gene id: 9544:SF1
uniprot id: H9EPF6
uniprot id: H9EPF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

9544:ACP1
gene id: 9544:ACP1
uniprot id: A0A5F7ZVN7
uniprot id: G7NB71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9544:CHMP2B
gene id: 9544:CHMP2B
uniprot id: A0A8J8YMS0
uniprot id: F7GEL2
names: Similarity
messages: Belongs to the SNF7 family.

9544:ECHDC1
gene id: 9544:ECHDC1
uniprot id: F6SPH3
uniprot id: H9YYZ7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9544:ICAM1
gene id: 9544:ICAM1
uniprot id: Q5NKV6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Homodimer. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells.
messages: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
messages: Membrane
messages: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

9544:NKG7
gene id: 9544:NKG7
uniprot id: A0A5K1VHF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9544:CPLANE2
gene id: 9544:CPLANE2
uniprot id: A0A8J8Y6W3
uniprot id: F7FNT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9544:BRK1
gene id: 9544:BRK1
uniprot id: H9Z3A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRK1 family.
messages: cytoskeleton

9544:EDN3
gene id: 9544:EDN3
uniprot id: A0A1D5QU72
uniprot id: F7FQK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9544:PRORP
gene id: 9544:PRORP
uniprot id: F7D7G2
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9544:TMEM47
gene id: 9544:TMEM47
uniprot id: F6SCM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9544:RPE65
gene id: 9544:RPE65
uniprot id: A0A5F7ZNP6
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

9544:ATP2B2
gene id: 9544:ATP2B2
uniprot id: F7G362
uniprot id: F7G366
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:GDF5
gene id: 9544:GDF5
uniprot id: F7EE07
names: Similarity
messages: Belongs to the TGF-beta family.

9544:SNX25
gene id: 9544:SNX25
uniprot id: F7HJ42
names: Similarity
messages: Belongs to the sorting nexin family.

9544:CNTNAP1
gene id: 9544:CNTNAP1
uniprot id: F7B7T3
uniprot id: F7HIS4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: paranodal septate junction

9544:FAM229A
gene id: 9544:FAM229A
uniprot id: F6YM49
names: Similarity
messages: Belongs to the FAM229 family.

9544:ADRB2
gene id: 9544:ADRB2
uniprot id: G7MVF9
uniprot id: Q28509
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
messages: Binds NHERF1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (By similarity). Interacts with USP20 and USP33 (By similarity). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4 (By similarity). Interacts with MARCHF2 (By similarity).
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
messages: Membrane
messages: Palmitoylated. Mainly palmitoylated at Cys-341. Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi. Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor. Could be depalmitoylated by LYPLA1 at the plasma membrane.
messages: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity).
messages: Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
messages: Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
messages: Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity).

9544:SLC20A2
gene id: 9544:SLC20A2
uniprot id: A0A8J8YBV3
uniprot id: F6WTV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

9544:RPN2
gene id: 9544:RPN2
uniprot id: F7CA11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9544:LOC713600
gene id: 9544:LOC713600
uniprot id: A0A5F7ZWD1
names: Similarity
messages: Belongs to the LCE family.

9544:CERS2
gene id: 9544:CERS2
uniprot id: A0A8J8XJU3
uniprot id: F7BTU2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9544:KCNK2
gene id: 9544:KCNK2
uniprot id: A0A1D5QMX8
uniprot id: A0A8J8XNW9
uniprot id: F7CHV4
uniprot id: F7GUQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9544:CHRDL1
gene id: 9544:CHRDL1
uniprot id: A0A8J8XCM4
uniprot id: F6W0P3
names: Subcellular Location Annotation
messages: Secreted

9544:ADD3
gene id: 9544:ADD3
uniprot id: A0A8J8XTH3
uniprot id: G7N141
uniprot id: H9EUT6
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9544:SMG1
gene id: 9544:SMG1
uniprot id: A0A5F7ZLC3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9544:PSMB9
gene id: 9544:PSMB9
uniprot id: A0A8J8XMR4
uniprot id: F6UNF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9544:NOL11
gene id: 9544:NOL11
uniprot id: H9FSM3
names: Subcellular Location Annotation
messages: nucleolus

9544:MLF1
gene id: 9544:MLF1
uniprot id: H9FUL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9544:ZDHHC3
gene id: 9544:ZDHHC3
uniprot id: A0A1D5QPT4
uniprot id: A0A5F7ZJZ7
uniprot id: A0A8J8XGC6
uniprot id: F7AYQ9
uniprot id: F7AYS4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9544:KCNA4
gene id: 9544:KCNA4
uniprot id: A0A8J8XU25
uniprot id: F6QDP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

9544:GADD45A
gene id: 9544:GADD45A
uniprot id: F7HPG4
names: Similarity
messages: Belongs to the GADD45 family.

9544:LYRM9
gene id: 9544:LYRM9
uniprot id: H9FR07
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

9544:NUDT10
gene id: 9544:NUDT10
uniprot id: F6YMU3
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9544:C13H2orf40
gene id: 9544:C13H2orf40
uniprot id: A0A8J8YAF3
uniprot id: G7NAV0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9544:MTFP1
gene id: 9544:MTFP1
uniprot id: A0A8J8YIY0
uniprot id: G7N3L0
names: Similarity
messages: Belongs to the MTFP1 family.

9544:HNRNPK
gene id: 9544:HNRNPK
uniprot id: F6VJH6
uniprot id: F6WZ02
uniprot id: F6WZ20
uniprot id: F7H3M0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9544:HPGD
gene id: 9544:HPGD
uniprot id: F6U1R8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:FABP5
gene id: 9544:FABP5
uniprot id: A0A8J8YP38
uniprot id: F6YIY5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:CXCR5
gene id: 9544:CXCR5
uniprot id: G7NCD4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:FMO4
gene id: 9544:FMO4
uniprot id: F7D7C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane

9544:GPRC5C
gene id: 9544:GPRC5C
uniprot id: A0A5F7ZAN4
uniprot id: A0A5F8ACT8
uniprot id: A0A5F8ARS5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:AGT
gene id: 9544:AGT
uniprot id: G7MFR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

9544:TTC30A
gene id: 9544:TTC30A
uniprot id: F6TGV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9544:PBX4
gene id: 9544:PBX4
uniprot id: A0A1D5R3C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9544:MARVELD3
gene id: 9544:MARVELD3
uniprot id: A0A1D5QZA8
uniprot id: A0A5F7ZY42
names: Subcellular Location Annotation
messages: Membrane

9544:LOC106992273
gene id: 9544:LOC106992273
uniprot id: H9ZBB2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:CAMLG
gene id: 9544:CAMLG
uniprot id: A0A1D5R0B5
uniprot id: A0A8J8XX77
uniprot id: H9G0B7
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9544:GSK3A
gene id: 9544:GSK3A
uniprot id: F7GQ30
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9544:THNSL1
gene id: 9544:THNSL1
uniprot id: F7H191
names: Similarity
messages: Belongs to the threonine synthase family.

9544:FGF7
gene id: 9544:FGF7
uniprot id: A0A8J8XV79
uniprot id: F7A1B0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:CD37
gene id: 9544:CD37
uniprot id: F6WD12
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:B3GAT3
gene id: 9544:B3GAT3
uniprot id: A0A1D5R236
uniprot id: A0A8J8YDB1
uniprot id: G7NCT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:LOC704337
gene id: 9544:LOC704337
uniprot id: G7MLG4
names: Similarity
messages: Belongs to the CFAP144 family.

9544:PCSK9
gene id: 9544:PCSK9
uniprot id: A8T666
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Cell surface
messages: Cleavage by furin and PCSK5 generates a truncated inactive protein that is unable to induce LDLR degradation.
messages: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Endosome
messages: Golgi apparatus
messages: Its proteolytic activity is autoinhibited by the non-covalent binding of the propeptide to the catalytic domain. Inhibited by EGTA (By similarity).
messages: Lysosome
messages: Monomer. Can self-associate to form dimers and higher multimers which may have increased LDLR degrading activity. The precursor protein but not the mature protein may form multimers. Interacts with APOB, VLDLR, LRP8/APOER2 and BACE1. The full-length immature form (pro-PCSK9) interacts with SCNN1A, SCNN1B and SCNN1G. The pro-PCSK9 form (via C-terminal domain) interacts with LDLR. Interacts (via the C-terminal domain) with ANXA2 (via repeat Annexin 1); the interaction inhibits the degradation of LDLR.
messages: Phosphorylation protects the propeptide against proteolysis.
messages: Secreted
messages: The C-terminal domain (CRD) is essential for the LDLR-binding and degrading activities.
messages: The catalytic domain is responsible for mediating its self-association.
messages: Undergoes autocatalytic cleavage in the endoplasmic reticulum to release the propeptide from the N-terminus and the cleavage of the propeptide is strictly required for its maturation and activation. The cleaved propeptide however remains associated with the catalytic domain through non-covalent interactions, preventing potential substrates from accessing its active site. As a result, it is secreted from cells as a propeptide-containing, enzymatically inactive protein (By similarity).

9544:SRC
gene id: 9544:SRC
uniprot id: I0FJ06
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9544:BMX
gene id: 9544:BMX
uniprot id: F7AH69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9544:TLX2
gene id: 9544:TLX2
uniprot id: A0A1D5R8F7
names: Subcellular Location Annotation
messages: Nucleus

9544:MEP1A
gene id: 9544:MEP1A
uniprot id: A0A8J8YQC1
uniprot id: F6TID4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:DMBX1
gene id: 9544:DMBX1
uniprot id: F7G2L1
names: Subcellular Location Annotation
messages: Nucleus

9544:HTR6
gene id: 9544:HTR6
uniprot id: A0A5F7ZDI3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:RAB38
gene id: 9544:RAB38
uniprot id: A0A8J8YCK6
uniprot id: F7FVM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9544:ZFPM2
gene id: 9544:ZFPM2
uniprot id: A0A8J8XAE5
uniprot id: G7MZX6
names: Subcellular Location Annotation
messages: Nucleus

9544:KCNJ15
gene id: 9544:KCNJ15
uniprot id: A0A8J8XWY3
uniprot id: F7CZK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9544:TFAP2A
gene id: 9544:TFAP2A
uniprot id: A0A1D5Q3I9
uniprot id: A0A1D5QYF1
uniprot id: F7HQR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9544:PEX7
gene id: 9544:PEX7
uniprot id: F7GN16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

9544:PDCL3
gene id: 9544:PDCL3
uniprot id: H9EX97
names: Similarity
messages: Belongs to the phosducin family.

9544:ARPC4
gene id: 9544:ARPC4
uniprot id: H9FNE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9544:B9D2
gene id: 9544:B9D2
uniprot id: A0A8J8XLJ1
uniprot id: F7HCV2
names: Subcellular Location Annotation
messages: cilium basal body

9544:IL6R
gene id: 9544:IL6R
uniprot id: A0A5F8AUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Membrane

9544:KDM5B
gene id: 9544:KDM5B
uniprot id: I0FFN8
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9544:ST6GAL1
gene id: 9544:ST6GAL1
uniprot id: A0A8J8XF67
uniprot id: F6TW24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:TACR2
gene id: 9544:TACR2
uniprot id: F6Q6V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:WDPCP
gene id: 9544:WDPCP
uniprot id: A0A1D5Q8Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat fritz family.
messages: Cell membrane
messages: Membrane
messages: cilium axoneme

9544:DLK2
gene id: 9544:DLK2
uniprot id: A0A8J8YHF3
uniprot id: F7G7Y2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:PRPF4B
gene id: 9544:PRPF4B
uniprot id: H9G1E3
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

9544:NTMT1
gene id: 9544:NTMT1
uniprot id: A0A5F7ZAY0
uniprot id: A0A8J8YG84
uniprot id: F7HMB4
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9544:CLCN3
gene id: 9544:CLCN3
uniprot id: A0A1D5Q4G1
uniprot id: H9EPI1
uniprot id: H9EPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9544:MYO1B
gene id: 9544:MYO1B
uniprot id: A0A8J8YRP1
uniprot id: F7AJ10
uniprot id: F7AJ56
uniprot id: G7N8J0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9544:LOC715795
gene id: 9544:LOC715795
uniprot id: A0A5F8AN82
uniprot id: F7GQZ4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9544:GNA15
gene id: 9544:GNA15
uniprot id: H9YW34
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9544:LHFPL1
gene id: 9544:LHFPL1
uniprot id: A0A5F8AC39
uniprot id: A0A8J8XX04
uniprot id: G7NT64
names: Subcellular Location Annotation
messages: Membrane

9544:DPAGT1
gene id: 9544:DPAGT1
uniprot id: A0A8J8XJW2
uniprot id: F6TXM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:ENO3
gene id: 9544:ENO3
uniprot id: A0A8J8XQF7
uniprot id: F7E3W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9544:PTGER3
gene id: 9544:PTGER3
uniprot id: F7HS70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:MCM7
gene id: 9544:MCM7
uniprot id: A0A8J8YIL7
uniprot id: H9FUI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9544:EMP3
gene id: 9544:EMP3
uniprot id: A0A8J8YAV2
uniprot id: F7H5H1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9544:EPHB4
gene id: 9544:EPHB4
uniprot id: F7E595
names: Subcellular Location Annotation
messages: Membrane

9544:MTERF3
gene id: 9544:MTERF3
uniprot id: G7MZT4
names: Similarity
messages: Belongs to the mTERF family.

9544:C16H17orf62
gene id: 9544:C16H17orf62
uniprot id: A0A8J8XYN3
uniprot id: H9ZDI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:GRB10
gene id: 9544:GRB10
uniprot id: A0A8J8XUH0
uniprot id: F7F404
uniprot id: G7MLA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9544:AGO1
gene id: 9544:AGO1
uniprot id: H9FSW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9544:SIRT2
gene id: 9544:SIRT2
uniprot id: F7H1P7
uniprot id: H9YXU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

9544:OR10A6
gene id: 9544:OR10A6
uniprot id: A0A8J8YMN3
uniprot id: F7F701
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:PSMA1
gene id: 9544:PSMA1
uniprot id: H9ENP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9544:UTP15
gene id: 9544:UTP15
uniprot id: F7DXL1
names: Subcellular Location Annotation
messages: nucleolus

9544:LOC720399
gene id: 9544:LOC720399
uniprot id: A0A8J8YNG6
uniprot id: G7MEB9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9544:PLBD1
gene id: 9544:PLBD1
uniprot id: F6TC57
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9544:COX8A
gene id: 9544:COX8A
uniprot id: A0A8J8YNF8
uniprot id: F6T9S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9544:APC2
gene id: 9544:APC2
uniprot id: F6VET0
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9544:SLC9A9
gene id: 9544:SLC9A9
uniprot id: H9FT94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9544:CEMIP
gene id: 9544:CEMIP
uniprot id: A0A8J8XVJ8
uniprot id: F6WYE4
names: Similarity
messages: Belongs to the CEMIP family.

9544:DIPK1A
gene id: 9544:DIPK1A
uniprot id: F7C4M8
names: Similarity
messages: Belongs to the DIPK family.

9544:GMFB
gene id: 9544:GMFB
uniprot id: H9FT52
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9544:ZFX
gene id: 9544:ZFX
uniprot id: A0A1D5QAI2
uniprot id: A0A1D5R9M9
names: Subcellular Location Annotation
messages: Nucleus

9544:VKORC1L1
gene id: 9544:VKORC1L1
uniprot id: A0A1D5Q1P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:DEFB1
gene id: 9544:DEFB1
uniprot id: O18794
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
messages: Membrane
messages: Monomer. Homodimer.
messages: Secreted

9544:FERMT2
gene id: 9544:FERMT2
uniprot id: I0FNS4
names: Similarity
messages: Belongs to the kindlin family.

9544:CDC42SE2
gene id: 9544:CDC42SE2
uniprot id: A0A8J8XNT0
uniprot id: G7MTX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9544:AQP10
gene id: 9544:AQP10
uniprot id: H9H4C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9544:INMT
gene id: 9544:INMT
uniprot id: F7HSK5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9544:ABCC5
gene id: 9544:ABCC5
uniprot id: A0A5F8A7D1
uniprot id: H9FND4
names: Subcellular Location Annotation
messages: Membrane

9544:LOC100429047
gene id: 9544:LOC100429047
uniprot id: A0A5F8AMY6
names: Similarity
messages: Belongs to the PRR20 family.

9544:TUBGCP2
gene id: 9544:TUBGCP2
uniprot id: H9FP14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9544:WNT6
gene id: 9544:WNT6
uniprot id: A0A5F7ZJ63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:POLD3
gene id: 9544:POLD3
uniprot id: A0A8J8XFJ8
uniprot id: F7BL41
names: Subcellular Location Annotation
messages: Nucleus

9544:GNPDA1
gene id: 9544:GNPDA1
uniprot id: A0A1D5R8R9
uniprot id: A0A8J8Y1N7
uniprot id: G7MVC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9544:PIR
gene id: 9544:PIR
uniprot id: A0A5F7ZJV2
uniprot id: F6S6S2
names: Similarity
messages: Belongs to the pirin family.

9544:MRPL3
gene id: 9544:MRPL3
uniprot id: A0A8J8XC44
uniprot id: F6XHQ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9544:TFE3
gene id: 9544:TFE3
uniprot id: A0A1D5QF51
uniprot id: A0A8J8XI43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9544:TMPRSS11B
gene id: 9544:TMPRSS11B
uniprot id: A0A5F7ZTT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9544:SPANXN
gene id: 9544:SPANXN
uniprot id: Q6S9I4
names: Similarity
messages: Belongs to the SPAN-X family.

9544:SFRP4
gene id: 9544:SFRP4
uniprot id: Q7YRN1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
messages: The FZ domain is involved in binding with Wnt ligands.

9544:MINAR2
gene id: 9544:MINAR2
uniprot id: A0A1D5QJF2
names: Similarity
messages: Belongs to the MINAR family.

9544:MRPL51
gene id: 9544:MRPL51
uniprot id: F6ZY79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Mitochondrion

9544:CD3G
gene id: 9544:CD3G
uniprot id: G7NCC1
uniprot id: H9ZF87
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9544:S1PR1
gene id: 9544:S1PR1
uniprot id: H9EUW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:UST
gene id: 9544:UST
uniprot id: H9EUJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9544:SOX2
gene id: 9544:SOX2
uniprot id: B8XIA2
names: Subcellular Location Annotation
messages: Nucleus

9544:PLK1
gene id: 9544:PLK1
uniprot id: A0A8J8XQA8
uniprot id: F7HSC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

9544:PSME4
gene id: 9544:PSME4
uniprot id: H9ET09
names: Similarity
messages: Belongs to the BLM10 family.

9544:LOC697599
gene id: 9544:LOC697599
uniprot id: F7GHB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9544:EDC3
gene id: 9544:EDC3
uniprot id: A0A8J8XQJ7
uniprot id: F7GKJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9544:ADRM1
gene id: 9544:ADRM1
uniprot id: A0A8J8Y651
uniprot id: F7FSU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

9544:ERH
gene id: 9544:ERH
uniprot id: I0FGK6
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9544:SNAP47
gene id: 9544:SNAP47
uniprot id: A0A8J8Y968
uniprot id: F7GP77
names: Similarity
messages: Belongs to the SVAP1 family.

9544:RRN3
gene id: 9544:RRN3
uniprot id: A0A8J8XWN2
uniprot id: H9FW48
names: Similarity
messages: Belongs to the RRN3 family.

9544:DHX15
gene id: 9544:DHX15
uniprot id: A0A8J8XNA6
uniprot id: F6YQX3
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9544:TIRAP
gene id: 9544:TIRAP
uniprot id: B3Y690
uniprot id: H9Z500
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

9544:TAS2R1
gene id: 9544:TAS2R1
uniprot id: A0A5F8A0R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:ATG4D
gene id: 9544:ATG4D
uniprot id: A0A5F8AE08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9544:ATP6AP1
gene id: 9544:ATP6AP1
uniprot id: I2CYP6
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

9544:MAPKAP1
gene id: 9544:MAPKAP1
uniprot id: A0A8J8XU29
uniprot id: F6U0S1
uniprot id: G7NEQ6
uniprot id: H9FZP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIN1 family.
messages: Cytoplasmic vesicle

9544:SLAIN2
gene id: 9544:SLAIN2
uniprot id: A0A5F7ZI08
uniprot id: H9YXL5
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9544:NPVF
gene id: 9544:NPVF
uniprot id: B5ABV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9544:LAMC1
gene id: 9544:LAMC1
uniprot id: F6WVB2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9544:SUV39H1
gene id: 9544:SUV39H1
uniprot id: A0A8J8XR04
uniprot id: F6X1Z9
uniprot id: F7APZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9544:DBNL
gene id: 9544:DBNL
uniprot id: A0A1D5REU8
uniprot id: H9FTD9
uniprot id: H9FTE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Early endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

9544:TMEM14B
gene id: 9544:TMEM14B
uniprot id: H9EXZ8
names: Similarity
messages: Belongs to the TMEM14 family.

9544:MTAP
gene id: 9544:MTAP
uniprot id: F6RQL9
uniprot id: H9FUP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9544:SLC5A6
gene id: 9544:SLC5A6
uniprot id: F6PWF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9544:MRPS33
gene id: 9544:MRPS33
uniprot id: A0A8J8YFY1
uniprot id: F7HBG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9544:PSME1
gene id: 9544:PSME1
uniprot id: F7FF62
names: Similarity
messages: Belongs to the PA28 family.

9544:STK17B
gene id: 9544:STK17B
uniprot id: H9EW56
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:RPS4Y1
gene id: 9544:RPS4Y1
uniprot id: I2CTN1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9544:B4GALT2
gene id: 9544:B4GALT2
uniprot id: A0A1D5Q0D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9544:LOC706568
gene id: 9544:LOC706568
uniprot id: A0A5F7ZPE7
names: Similarity
messages: Belongs to the peptidase C14A family.

9544:ATG7
gene id: 9544:ATG7
uniprot id: A0A8J8YRG3
uniprot id: G7MKQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

9544:PITX2
gene id: 9544:PITX2
uniprot id: A0A8J8XTP1
uniprot id: F6UF10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9544:VPS33B
gene id: 9544:VPS33B
uniprot id: A0A8J8XQG0
uniprot id: G7MVZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9544:SNCA
gene id: 9544:SNCA
uniprot id: A0A8J8Y4A0
uniprot id: G7MTE2
uniprot id: P61143
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
messages: Belongs to the synuclein family.
messages: Cytoplasm
messages: Membrane
messages: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
messages: Nucleus
messages: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress.
messages: Secreted
messages: Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).
messages: Synapse
messages: Ubiquitinated. The predominant conjugate is the diubiquitinated form.
messages: axon

9544:LOC106995824
gene id: 9544:LOC106995824
uniprot id: I0FUI5
names: Similarity
messages: Belongs to the SSX family.

9544:STC2
gene id: 9544:STC2
uniprot id: A0A8J8YKR9
uniprot id: F6WDI3
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9544:HOOK3
gene id: 9544:HOOK3
uniprot id: H9EMU3
uniprot id: H9G0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9544:CHCHD6
gene id: 9544:CHCHD6
uniprot id: A0A1D5Q786
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9544:SLC24A4
gene id: 9544:SLC24A4
uniprot id: F6S7H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9544:DNM1L
gene id: 9544:DNM1L
uniprot id: F7GI64
uniprot id: F7HK42
uniprot id: F7HM23
uniprot id: G7N6P0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9544:HBB
gene id: 9544:HBB
uniprot id: C6KGT1
names: Similarity
messages: Belongs to the globin family.

9544:MDFI
gene id: 9544:MDFI
uniprot id: A0A8J8Y531
uniprot id: F6WC94
names: Similarity
messages: Belongs to the MDFI family.

9544:PABPC5
gene id: 9544:PABPC5
uniprot id: Q7JGR2
names: Function
names: Subcellular Location Annotation
messages: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).
messages: Cytoplasm

9544:CNGA4
gene id: 9544:CNGA4
uniprot id: F7BPP2
names: Subcellular Location Annotation
messages: Membrane

9544:KIF1B
gene id: 9544:KIF1B
uniprot id: A0A5F8AN20
uniprot id: H9ETN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

9544:EIF1
gene id: 9544:EIF1
uniprot id: A0A8J8Y6N6
uniprot id: G7NIJ1
names: Similarity
messages: Belongs to the SUI1 family.

9544:MMP8
gene id: 9544:MMP8
uniprot id: A0A5F8A8W4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9544:GJA3
gene id: 9544:GJA3
uniprot id: A0A5F7ZEN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9544:PLPPR5
gene id: 9544:PLPPR5
uniprot id: F6WR81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9544:ASB15
gene id: 9544:ASB15
uniprot id: F7BUA7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9544:RUVBL2
gene id: 9544:RUVBL2
uniprot id: F6ZUY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9544:ACSS2
gene id: 9544:ACSS2
uniprot id: F7EME7
uniprot id: I2CVW8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9544:PAGE1
gene id: 9544:PAGE1
uniprot id: F7CNQ5
names: Similarity
messages: Belongs to the GAGE family.

9544:PPA2
gene id: 9544:PPA2
uniprot id: F6PN98
names: Similarity
messages: Belongs to the PPase family.

9544:LOC702046
gene id: 9544:LOC702046
uniprot id: A0A5F7Z8K8
uniprot id: F6WMH1
names: Similarity
messages: Belongs to the serpin family.

9544:MRPL42
gene id: 9544:MRPL42
uniprot id: A0A8J8YJL8
uniprot id: G7N7Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9544:MRPS17
gene id: 9544:MRPS17
uniprot id: A0A1D5Q4H5
uniprot id: A0A8J8YM43
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9544:MYF6
gene id: 9544:MYF6
uniprot id: A0A8J8YAJ0
uniprot id: F7HGT9
names: Subcellular Location Annotation
messages: Nucleus

9544:BNIP3L
gene id: 9544:BNIP3L
uniprot id: H9EVM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9544:IL23A
gene id: 9544:IL23A
uniprot id: A0A8J8XF71
uniprot id: F7HQI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9544:FGF19
gene id: 9544:FGF19
uniprot id: A0A5F8AV87
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9544:CSRNP1
gene id: 9544:CSRNP1
uniprot id: A0A8J8YB40
uniprot id: F6TYP2
uniprot id: H9ZCF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9544:ACTR1B
gene id: 9544:ACTR1B
uniprot id: H9EUC6
names: Similarity
messages: Belongs to the actin family.

9544:SFT2D2
gene id: 9544:SFT2D2
uniprot id: F7H6K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9544:TAMM41
gene id: 9544:TAMM41
uniprot id: G7MKQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9544:TTC26
gene id: 9544:TTC26
uniprot id: A0A1D5Q9K7
names: Similarity
messages: Belongs to the IFT56 family.

9544:HSPB1
gene id: 9544:HSPB1
uniprot id: F6XTF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9544:DPY19L3
gene id: 9544:DPY19L3
uniprot id: I0FPF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9544:SETD3
gene id: 9544:SETD3
uniprot id: A0A8J8XZY5
uniprot id: I0FVL8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Interacts with MYOD1.

9544:UBA52
gene id: 9544:UBA52
uniprot id: F7GN03
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

9544:FYN
gene id: 9544:FYN
uniprot id: A0A8J8XFY0
uniprot id: F7FVL2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9544:LIPM
gene id: 9544:LIPM
uniprot id: A0A1D5R0C7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9544:UNC50
gene id: 9544:UNC50
uniprot id: A0A8J8XVY3
uniprot id: F6W7H0
uniprot id: Q4G3Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane
messages: Nucleus inner membrane

9544:RPL7A
gene id: 9544:RPL7A
uniprot id: F6ZCN6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

9544:FXR2
gene id: 9544:FXR2
uniprot id: I0FHK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Postsynapse
messages: Synapse

9544:SMARCA1
gene id: 9544:SMARCA1
uniprot id: F6TKC4
uniprot id: F7F0X3
uniprot id: H9FYQ7
uniprot id: I0FUD4
uniprot id: I2CVK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9544:PCMTD1
gene id: 9544:PCMTD1
uniprot id: A0A8J8XTC9
uniprot id: F7EGP9
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9544:MAP1LC3A
gene id: 9544:MAP1LC3A
uniprot id: F6UA91
names: Similarity
messages: Belongs to the ATG8 family.

9544:IRF5
gene id: 9544:IRF5
uniprot id: A0A8J8Y769
uniprot id: F6X265
names: Subcellular Location Annotation
messages: Nucleus

9544:LOC720015
gene id: 9544:LOC720015
uniprot id: A0A8J8Y758
uniprot id: F7BG90
names: Similarity
messages: Belongs to the GroES chaperonin family.

9544:CALCB
gene id: 9544:CALCB
uniprot id: A0A8J8XY27
uniprot id: F6US88
names: Similarity
messages: Belongs to the calcitonin family.

9544:LOC696748
gene id: 9544:LOC696748
uniprot id: A0A8J8YR21
uniprot id: F7D4K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9544:PRSS35
gene id: 9544:PRSS35
uniprot id: Q1WK24
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 342 which is replaced by a Thr, suggesting that it has no protease activity.
messages: Belongs to the peptidase S1 family.
messages: Secreted

9544:LOC715827
gene id: 9544:LOC715827
uniprot id: G7MYJ8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:WSCD1
gene id: 9544:WSCD1
uniprot id: F6QL12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Golgi apparatus membrane
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9544:ACSL6
gene id: 9544:ACSL6
uniprot id: H9ETN8
uniprot id: H9ETN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

9544:SPCS3
gene id: 9544:SPCS3
uniprot id: H9ENW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:PTOV1
gene id: 9544:PTOV1
uniprot id: H9FVX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
messages: Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: May interact with CREBBP. Interacts with FLOT1.
messages: Nucleus
messages: perinuclear region

9544:CLDN11
gene id: 9544:CLDN11
uniprot id: A0A8J8XX13
uniprot id: I0FS42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:PPP2R2B
gene id: 9544:PPP2R2B
uniprot id: A0A1D5RB25
uniprot id: F6S1Q3
uniprot id: F6VLZ3
uniprot id: H9FWK8
uniprot id: H9FWL0
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9544:ANKRD34B
gene id: 9544:ANKRD34B
uniprot id: A0A8J8XDJ2
uniprot id: F6QSM6
names: Similarity
messages: Belongs to the ANKRD34 family.

9544:LOC706606
gene id: 9544:LOC706606
uniprot id: F7HIX4
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9544:HIST1H3D
gene id: 9544:HIST1H3D
uniprot id: A0A8J8Y153
uniprot id: F7BRX2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:RBM3
gene id: 9544:RBM3
uniprot id: H9FY14
names: Subcellular Location Annotation
messages: Cytoplasm

9544:TNFSF11
gene id: 9544:TNFSF11
uniprot id: A0A8J8XHD7
uniprot id: F7F5R8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9544:DPP7
gene id: 9544:DPP7
uniprot id: H9EXB4
names: Similarity
messages: Belongs to the peptidase S28 family.

9544:ARAP3
gene id: 9544:ARAP3
uniprot id: A0A1D5QLW8
uniprot id: A0A1D5RDA8
names: Subcellular Location Annotation
messages: Cytoplasm

9544:TMEM173
gene id: 9544:TMEM173
uniprot id: H9YZQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9544:ASRGL1
gene id: 9544:ASRGL1
uniprot id: A0A8J8YPW3
uniprot id: F6SYY2
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9544:RFLNA
gene id: 9544:RFLNA
uniprot id: A0A1D5QKS2
uniprot id: A0A8J8YB94
uniprot id: F7DM58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9544:DDI1
gene id: 9544:DDI1
uniprot id: A0A8J8YGZ5
uniprot id: F7GE01
names: Similarity
messages: Belongs to the DDI1 family.

9544:NKX2-6
gene id: 9544:NKX2-6
uniprot id: F7HNC4
names: Subcellular Location Annotation
messages: Nucleus

9544:SLC39A8
gene id: 9544:SLC39A8
uniprot id: A0A8J8Y4Y7
uniprot id: F7HKH5
names: Subcellular Location Annotation
messages: Membrane

9544:TRPC1
gene id: 9544:TRPC1
uniprot id: H9FZ68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9544:TAS2R16
gene id: 9544:TAS2R16
uniprot id: A0A8J8XI06
uniprot id: Q645S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:SNX8
gene id: 9544:SNX8
uniprot id: A0A1D5QR07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9544:CD209L2
gene id: 9544:CD209L2
uniprot id: Q8MIS5
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: In vitro, is a weak receptor for HIV-1 and SIV and poorly transmits HIV-1 to permissive T-cells relative to CD209.
messages: Membrane
messages: Predominantly expressed in liver and axillary lymph nodes. At very low levels also found in other tissues.
messages: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity).

9544:RAB11FIP4
gene id: 9544:RAB11FIP4
uniprot id: F7HGQ6
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

9544:ABR
gene id: 9544:ABR
uniprot id: A0A5K1UBS2
uniprot id: F6Y9W7
uniprot id: H9Z815
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9544:GNAI3
gene id: 9544:GNAI3
uniprot id: A0A8J8YS47
uniprot id: F6VL43
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:PPP1R11
gene id: 9544:PPP1R11
uniprot id: H9EPY1
uniprot id: Q5TM51
names: Function
names: PTM
names: Subunit
messages: Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
messages: Auto-ubiquitinated.
messages: Interacts with TLR2 and UBE2D2.

9544:NDRG1
gene id: 9544:NDRG1
uniprot id: F6SHZ8
uniprot id: F6SI55
names: Similarity
messages: Belongs to the NDRG family.

9544:CYP2C76
gene id: 9544:CYP2C76
uniprot id: D5FF20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9544:RTD1B
gene id: 9544:RTD1B
uniprot id: P82271
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the alpha-defensin family. Theta subfamily.
messages: Forms a cyclic peptide with 1 subunit B (RTD-2) or with 1 subunit A (RTD-1). An additional intersubunit disulfide bond is formed.
messages: RTD-1 and RTD-2 have similar antimicrobial activities against the Gram-positive bacteria S.aureus 502A and L.monocytogenes, the Gram-negative bacterium S.typhimurium, and the fungi C.albicans 16820 and C.neoformans 271A. RTD-2 is 2-3-fold less active than RTD-1 against E.coli ML35.
messages: RTD-1 expression begins early during granulocyte myelopoiesis.
messages: RTD-1 is 10-fold more present in cells than RTD-2.
messages: RTD-1 is a cyclic heterodimer composed of subunits A and B; disulfide-linked. RTD-2 is a cyclic homodimer composed of two subunits B; disulfide-linked.
messages: RTD-1 is expressed in bone marrow. Detected in promyelocytes, myelocytes and mature neutrophils and monocytes.

9544:EMC8
gene id: 9544:EMC8
uniprot id: A0A8J8Y9C4
uniprot id: F7HCZ6
uniprot id: H9Z0Z6
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9544:NDUFA2
gene id: 9544:NDUFA2
uniprot id: H9EV74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9544:PLD4
gene id: 9544:PLD4
uniprot id: F7CNC1
names: Similarity
messages: Belongs to the phospholipase D family.

9544:TSHZ1
gene id: 9544:TSHZ1
uniprot id: G7NKA3
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

9544:LOC699110
gene id: 9544:LOC699110
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:SSTR4
gene id: 9544:SSTR4
uniprot id: F7C9S6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:GLS
gene id: 9544:GLS
uniprot id: H9ESE7
uniprot id: I2CUE6
names: Similarity
messages: Belongs to the glutaminase family.

9544:H2AFJ
gene id: 9544:H2AFJ
uniprot id: F7DHS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:MCIDAS
gene id: 9544:MCIDAS
uniprot id: F7HUH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9544:RRAD
gene id: 9544:RRAD
uniprot id: A0A5F8AFL7
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9544:STIM2
gene id: 9544:STIM2
uniprot id: A0A1D5RKE1
uniprot id: F7EUD7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:TPH2
gene id: 9544:TPH2
uniprot id: Q2HZ26
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9544:TSN
gene id: 9544:TSN
uniprot id: A0A1D5Q6F0
uniprot id: A0A8J8YCX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9544:OXCT1
gene id: 9544:OXCT1
uniprot id: A0A1D5QBH8
uniprot id: F7GQS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9544:FABP3
gene id: 9544:FABP3
uniprot id: A0A8J8YTA0
uniprot id: G7MI71
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9544:MTRF1
gene id: 9544:MTRF1
uniprot id: A0A8J8Y198
uniprot id: F7DST9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9544:PHKA2
gene id: 9544:PHKA2
uniprot id: A0A5F8ABQ9
uniprot id: A0A8J8XZ37
uniprot id: F7AXZ8
uniprot id: F7B2V1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9544:GAB2
gene id: 9544:GAB2
uniprot id: F6VIK2
names: Similarity
messages: Belongs to the GAB family.

9544:CENPO
gene id: 9544:CENPO
uniprot id: A0A8J8YSA7
uniprot id: G7N9J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9544:SLC7A9
gene id: 9544:SLC7A9
uniprot id: A0A8J8YCY1
uniprot id: F6XDS9
names: Subcellular Location Annotation
messages: Membrane

9544:PIANP
gene id: 9544:PIANP
uniprot id: A0A5F8AU43
uniprot id: A0A8J8XH76
uniprot id: F6PRP7
names: Subcellular Location Annotation
messages: Membrane

9544:CDC42
gene id: 9544:CDC42
uniprot id: A0A8J8YSN1
uniprot id: F7FVX9
uniprot id: H9G2P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

9544:ZFP69B
gene id: 9544:ZFP69B
uniprot id: A0A8J8XEV5
uniprot id: F7FR23
names: Subcellular Location Annotation
messages: Nucleus

9544:TMEM231
gene id: 9544:TMEM231
uniprot id: H9EWK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

9544:SNRPF
gene id: 9544:SNRPF
uniprot id: I0FJY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9544:PDCL
gene id: 9544:PDCL
uniprot id: A0A8J8XHW7
uniprot id: F7F3M0
names: Similarity
messages: Belongs to the phosducin family.

9544:WASF2
gene id: 9544:WASF2
uniprot id: F7E520
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9544:POLR2J
gene id: 9544:POLR2J
uniprot id: H9EMC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9544:COPZ2
gene id: 9544:COPZ2
uniprot id: F6T427
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9544:TSSK6
gene id: 9544:TSSK6
uniprot id: A0A8J8Y220
uniprot id: G7NNH2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:FOXJ1
gene id: 9544:FOXJ1
uniprot id: A0A8J8YA37
uniprot id: F7EXX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FOXJ1 family.
messages: Nucleus

9544:PIK3CA
gene id: 9544:PIK3CA
uniprot id: H9FVU5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9544:VPS26A
gene id: 9544:VPS26A
uniprot id: H9EPD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9544:LRRC8C
gene id: 9544:LRRC8C
uniprot id: A0A8J8XE06
uniprot id: F7HLE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9544:CBX1
gene id: 9544:CBX1
uniprot id: A0A5F7ZEG7
uniprot id: H9EPB7
names: Subcellular Location Annotation
messages: Nucleus

9544:DNAJC22
gene id: 9544:DNAJC22
uniprot id: F7GW88
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9544:YPEL2
gene id: 9544:YPEL2
uniprot id: A0A8J8XTF4
uniprot id: G7NHY7
names: Similarity
messages: Belongs to the yippee family.

9544:IFNA2
gene id: 9544:IFNA2
uniprot id: B6CK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:TMCO1
gene id: 9544:TMCO1
uniprot id: A0A8J8Y534
uniprot id: H9YVU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.
messages: Membrane

9544:ERCC1
gene id: 9544:ERCC1
uniprot id: A0A1D5Q468
uniprot id: F6YL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

9544:EEF1AKMT2
gene id: 9544:EEF1AKMT2
uniprot id: F6VWE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

9544:SNX30
gene id: 9544:SNX30
uniprot id: F7GDT2
names: Similarity
messages: Belongs to the sorting nexin family.

9544:LOC715257
gene id: 9544:LOC715257
uniprot id: H9ZBL7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:NUMB
gene id: 9544:NUMB
uniprot id: G7MYL6
uniprot id: H9ETQ5
uniprot id: H9ETT6
uniprot id: H9ZER2
uniprot id: H9ZER3
uniprot id: I0FVZ9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9544:INCENP
gene id: 9544:INCENP
uniprot id: A0A5F8A3R6
uniprot id: A0A5F8APE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

9544:TPT1
gene id: 9544:TPT1
uniprot id: F7HLW4
names: Similarity
messages: Belongs to the TCTP family.

9544:ODR4
gene id: 9544:ODR4
uniprot id: F7EE90
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9544:TAC1
gene id: 9544:TAC1
uniprot id: F6VX78
uniprot id: H9FYZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9544:PARP12
gene id: 9544:PARP12
uniprot id: H9ZCG0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9544:IFT46
gene id: 9544:IFT46
uniprot id: A0A8J8Y8V2
uniprot id: G7NCC8
uniprot id: H9ESL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9544:HPS5
gene id: 9544:HPS5
uniprot id: G7NDS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9544:STK32B
gene id: 9544:STK32B
uniprot id: A0A8J8XNZ4
uniprot id: G7MSJ4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:HOMER3
gene id: 9544:HOMER3
uniprot id: F7FF07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9544:IRAK4
gene id: 9544:IRAK4
uniprot id: F7HHC6
uniprot id: H9FV97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9544:SULT1C4
gene id: 9544:SULT1C4
uniprot id: A0A5F8AAB7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9544:STON2
gene id: 9544:STON2
uniprot id: A0A5F8ACL5
uniprot id: F7H5J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

9544:CHD1
gene id: 9544:CHD1
uniprot id: A0A1D5RAG7
names: Subcellular Location Annotation
messages: Nucleus

9544:MPI
gene id: 9544:MPI
uniprot id: A0A1D5Q678
uniprot id: A0A8J8XMZ4
uniprot id: G7MYC5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9544:IDH3A
gene id: 9544:IDH3A
uniprot id: I2CW30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9544:HOXC11
gene id: 9544:HOXC11
uniprot id: F6R720
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9544:ADH6
gene id: 9544:ADH6
uniprot id: F6XW80
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9544:AFP
gene id: 9544:AFP
uniprot id: F6VWH6
names: Subcellular Location Annotation
messages: Secreted

9544:TLR2
gene id: 9544:TLR2
uniprot id: B3Y618
uniprot id: B6CJY9
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
messages: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).
messages: Membrane
messages: Membrane raft
messages: The ATG16L1-binding motif mediates interaction with ATG16L1.
messages: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
messages: phagosome membrane

9544:TJP1
gene id: 9544:TJP1
uniprot id: H9FZ35
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9544:ST18
gene id: 9544:ST18
uniprot id: H9G2C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9544:ADCY7
gene id: 9544:ADCY7
uniprot id: A0A1D5QQN7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9544:PIF1
gene id: 9544:PIF1
uniprot id: A0A1D5Q3I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

9544:NFRKB
gene id: 9544:NFRKB
uniprot id: G7NCZ7
names: Subcellular Location Annotation
messages: Nucleus

9544:GEMIN2
gene id: 9544:GEMIN2
uniprot id: F7DCU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

9544:IL26
gene id: 9544:IL26
uniprot id: A0A7R8GUP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9544:MB
gene id: 9544:MB
uniprot id: A0A8J8Y6Y7
uniprot id: G7N3Q2
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9544:MSRB3
gene id: 9544:MSRB3
uniprot id: H9FSD0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9544:SEMA4F
gene id: 9544:SEMA4F
uniprot id: A0A1D5QP56
uniprot id: A0A8J8YQR7
uniprot id: F7DBA4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NSMCE1
gene id: 9544:NSMCE1
uniprot id: H9FQY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9544:MCHR1
gene id: 9544:MCHR1
uniprot id: Q8MJ89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with NCDN.
messages: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

9544:TPST1
gene id: 9544:TPST1
uniprot id: F7GLX0
uniprot id: I0FLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9544:HFE
gene id: 9544:HFE
uniprot id: A0A8J8YEH6
uniprot id: G7MR22
names: Similarity
messages: Belongs to the MHC class I family.

9544:TPD52L2
gene id: 9544:TPD52L2
uniprot id: A0A1D5QXB8
uniprot id: A0A1D5RA40
names: Similarity
messages: Belongs to the TPD52 family.

9544:FN1
gene id: 9544:FN1
uniprot id: A0A5F7ZU06
uniprot id: A0A8J8Y286
uniprot id: F7FHW4
uniprot id: G7N8U7
names: Function
messages: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.

9544:FH
gene id: 9544:FH
uniprot id: F6VWV9
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9544:STK40
gene id: 9544:STK40
uniprot id: H9G0I4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9544:MAPK1
gene id: 9544:MAPK1
uniprot id: F7ECR3
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola
messages: focal adhesion

9544:CAV1
gene id: 9544:CAV1
uniprot id: A0A8J8XYC0
uniprot id: F7C1V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: caveola

9544:RETREG1
gene id: 9544:RETREG1
uniprot id: F7D6D3
uniprot id: F7D6D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CILP
gene id: 9544:CILP
uniprot id: A0A8J8XKM4
uniprot id: F6YJ87
names: Subcellular Location Annotation
messages: extracellular matrix

9544:AZIN1
gene id: 9544:AZIN1
uniprot id: F7B9N8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9544:UPP1
gene id: 9544:UPP1
uniprot id: A0A8J8Y8S2
uniprot id: F7F1M1
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9544:TRADD
gene id: 9544:TRADD
uniprot id: A0A8J8YR56
uniprot id: H9ZES5
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

9544:ERBB3
gene id: 9544:ERBB3
uniprot id: G7N7B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9544:MEOX2
gene id: 9544:MEOX2
uniprot id: A0A8J8XZL0
uniprot id: F7C188
names: Subcellular Location Annotation
messages: Nucleus

9544:COQ3
gene id: 9544:COQ3
uniprot id: A0A5F8A0J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9544:GRAMD1A
gene id: 9544:GRAMD1A
uniprot id: A0A5K1VTX9
uniprot id: A0A8J8Y129
uniprot id: G7NM35
uniprot id: H9FXQ6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:CPT1C
gene id: 9544:CPT1C
uniprot id: A0A5F8A9H3
uniprot id: A0A5K1V0V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9544:EFHB
gene id: 9544:EFHB
uniprot id: F6ZB01
names: Subcellular Location Annotation
messages: cilium axoneme

9544:LOC702145
gene id: 9544:LOC702145
uniprot id: F7HC70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CDC42EP4
gene id: 9544:CDC42EP4
uniprot id: A0A8J8YDM3
uniprot id: F7F354
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9544:ARPC3
gene id: 9544:ARPC3
uniprot id: F7H998
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9544:MEAF6
gene id: 9544:MEAF6
uniprot id: A0A5K1U4P9
uniprot id: F7GRW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

9544:EMX2
gene id: 9544:EMX2
uniprot id: I2CUG2
names: Subcellular Location Annotation
messages: Nucleus

9544:TRIM15
gene id: 9544:TRIM15
uniprot id: Q5TM55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis. Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2. Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN. Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS. Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm. Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs).
messages: Interacts with paxillin/PXN; this interaction recruits TRIM15 to focal adhesions. Interacts with TRIM8; this interaction prevents TRIM8 cytoplasmic translocation.
messages: Nucleus
messages: focal adhesion

9544:LOC106992887
gene id: 9544:LOC106992887
uniprot id: A0A1D5QTM0
names: Similarity
messages: Belongs to the FAM136 family.

9544:MLLT11
gene id: 9544:MLLT11
uniprot id: A0A8J8YPB8
uniprot id: H9EVH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9544:CLDN7
gene id: 9544:CLDN7
uniprot id: A0A1D5RHW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9544:ZNF449
gene id: 9544:ZNF449
uniprot id: A0A8J8YJH3
uniprot id: F7HIU7
names: Subcellular Location Annotation
messages: Nucleus

9544:NPSR1
gene id: 9544:NPSR1
uniprot id: Q56H79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.

9544:VPS45
gene id: 9544:VPS45
uniprot id: G7MDG6
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9544:TSPAN33
gene id: 9544:TSPAN33
uniprot id: F7H8W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9544:SLC26A7
gene id: 9544:SLC26A7
uniprot id: F7D455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9544:FERMT3
gene id: 9544:FERMT3
uniprot id: A0A5K1VG20
names: Similarity
messages: Belongs to the kindlin family.

9544:DYNLL1
gene id: 9544:DYNLL1
uniprot id: H9H2R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9544:NDC1
gene id: 9544:NDC1
uniprot id: G7MH71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

9544:DOCK9
gene id: 9544:DOCK9
uniprot id: F6ZZG2
uniprot id: F7A5B2
names: Similarity
messages: Belongs to the DOCK family.

9544:HOXC6
gene id: 9544:HOXC6
uniprot id: A0A8J8Y0V9
uniprot id: F7HTX2
names: Subcellular Location Annotation
messages: Nucleus

9544:TNPO2
gene id: 9544:TNPO2
uniprot id: A0A8J8YHM1
uniprot id: F6YXG7
uniprot id: F6YXH7
names: Subcellular Location Annotation
messages: Cytoplasm

9544:SLC6A9
gene id: 9544:SLC6A9
uniprot id: A0A5K1VBL3
uniprot id: F6UD64
uniprot id: H9FYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9544:BRINP2
gene id: 9544:BRINP2
uniprot id: A0A8J8YC90
uniprot id: G7MFE5
names: Similarity
messages: Belongs to the BRINP family.

9544:TOP3A
gene id: 9544:TOP3A
uniprot id: H9EWR7
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9544:CACNB2
gene id: 9544:CACNB2
uniprot id: A0A1D5R992
uniprot id: F6SWC7
uniprot id: F6SWD8
uniprot id: F6SWI4
uniprot id: F7GXI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

9544:ASB17
gene id: 9544:ASB17
uniprot id: F6YJG0
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9544:TRIAP1
gene id: 9544:TRIAP1
uniprot id: G7N5Y6
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9544:ENO4
gene id: 9544:ENO4
uniprot id: F6SSS8
names: Similarity
messages: Belongs to the enolase family.

9544:CENPK
gene id: 9544:CENPK
uniprot id: H9ZC97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9544:NADK
gene id: 9544:NADK
uniprot id: F7FZM8
names: Similarity
messages: Belongs to the NAD kinase family.

9544:ELOVL2
gene id: 9544:ELOVL2
uniprot id: A0A1D5QUB3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9544:LOC709535
gene id: 9544:LOC709535
uniprot id: I2CUH9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:TRAPPC6B
gene id: 9544:TRAPPC6B
uniprot id: A0A1D5Q1H0
uniprot id: A0A8J8XUC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9544:ITGB6
gene id: 9544:ITGB6
uniprot id: A0A1D5QZT0
uniprot id: A0A8J8XVJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9544:TPM1
gene id: 9544:TPM1
uniprot id: A0A5K1UZR5
uniprot id: F7GV59
uniprot id: F7GV63
uniprot id: H9ELS7
uniprot id: I0FUQ5
uniprot id: I2CXK4
uniprot id: I2CXK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9544:SYN3
gene id: 9544:SYN3
uniprot id: F7HFD1
names: Similarity
messages: Belongs to the synapsin family.

9544:SUOX
gene id: 9544:SUOX
uniprot id: A0A5F8AS39
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Homodimer.
messages: Mitochondrion intermembrane space

9544:NXPH3
gene id: 9544:NXPH3
uniprot id: F7FIL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9544:IL17F
gene id: 9544:IL17F
uniprot id: A0A8J8XGQ6
uniprot id: F7HK33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9544:HMGCS1
gene id: 9544:HMGCS1
uniprot id: F7HQ90
uniprot id: G8F1C3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9544:LOC702006
gene id: 9544:LOC702006
uniprot id: G7NSX8
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9544:RUNX3
gene id: 9544:RUNX3
uniprot id: H9ZEQ8
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9544:ABCD3
gene id: 9544:ABCD3
uniprot id: A0A5F7ZJ08
uniprot id: H9ESW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9544:PEX10
gene id: 9544:PEX10
uniprot id: F7ENR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9544:CD2
gene id: 9544:CD2
uniprot id: F7DS86
uniprot id: Q6SZ60
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9544:TM9SF2
gene id: 9544:TM9SF2
uniprot id: A0A8J8XCG4
uniprot id: G7NJJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9544:SCG3
gene id: 9544:SCG3
uniprot id: A0A8J8YHC9
uniprot id: F7HMQ6
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: secretory vesicle membrane

9544:MAP3K14
gene id: 9544:MAP3K14
uniprot id: A0A8J8XBG1
uniprot id: F7B742
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9544:B4GALT4
gene id: 9544:B4GALT4
uniprot id: A0A8J8XUS8
uniprot id: F7HPG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9544:ELF4
gene id: 9544:ELF4
uniprot id: F7F6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9544:CYP2C18
gene id: 9544:CYP2C18
uniprot id: E0V8I5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9544:LOC711329
gene id: 9544:LOC711329
uniprot id: A0A7R8C317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9544:SLC25A25
gene id: 9544:SLC25A25
uniprot id: A0A5F8ABB0
uniprot id: F6W020
uniprot id: F7EIL8
uniprot id: H9FPJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9544:RSAD2
gene id: 9544:RSAD2
uniprot id: F6XVY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9544:MRPL24
gene id: 9544:MRPL24
uniprot id: A0A8J8YI65
uniprot id: F7HPI2
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9544:SCN4A
gene id: 9544:SCN4A
uniprot id: F6ZQ36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9544:ATE1
gene id: 9544:ATE1
uniprot id: A0A5F7ZQA6
uniprot id: H9FP82
uniprot id: H9FP83
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9544:SCN11A
gene id: 9544:SCN11A
uniprot id: F7FVT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9544:SPSB3
gene id: 9544:SPSB3
uniprot id: A0A5F8AGX6
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9544:HLCS
gene id: 9544:HLCS
uniprot id: A0A5F7ZY99
uniprot id: H9EWC5
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9544:CMAH
gene id: 9544:CMAH
uniprot id: Q9TUJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMP-Neu5Ac hydroxylase family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Cytoplasm
messages: Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.

9544:FADS3
gene id: 9544:FADS3
uniprot id: F6YUG7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9544:TMEM205
gene id: 9544:TMEM205
uniprot id: A0A8J8YJL1
uniprot id: H9YY46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9544:EPHB2
gene id: 9544:EPHB2
uniprot id: I2CV74
names: Subcellular Location Annotation
messages: Membrane

9544:JMY
gene id: 9544:JMY
uniprot id: A0A1D5R8P2
names: Subcellular Location Annotation
messages: Membrane

9544:SLC7A5
gene id: 9544:SLC7A5
uniprot id: H9ZDY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9544:SLC7A2
gene id: 9544:SLC7A2
uniprot id: A0A5F8A3A8
uniprot id: F6XEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9544:ARHGAP32
gene id: 9544:ARHGAP32
uniprot id: A0A5F8AFZ7
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

9544:IGFBP6
gene id: 9544:IGFBP6
uniprot id: A0A8J8XCA5
uniprot id: G7N736
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:SPA17
gene id: 9544:SPA17
uniprot id: F6THH3
uniprot id: Q9BDQ6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9544:CBX7
gene id: 9544:CBX7
uniprot id: F7BE16
uniprot id: H9FS56
names: Subcellular Location Annotation
messages: Nucleus

9544:SNX10
gene id: 9544:SNX10
uniprot id: F7E6U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9544:LOC106997862
gene id: 9544:LOC106997862
uniprot id: A0A8J8XEY8
uniprot id: F7HAP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:GLYAT
gene id: 9544:GLYAT
uniprot id: A0A8J8Y488
uniprot id: F7HA37
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9544:SMIM7
gene id: 9544:SMIM7
uniprot id: H9ENB3
names: Similarity
messages: Belongs to the SMIM7 family.

9544:CORIN
gene id: 9544:CORIN
uniprot id: A0A1D5R139
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:NEUROD4
gene id: 9544:NEUROD4
uniprot id: A0A5F8A497
names: Subcellular Location Annotation
messages: Nucleus

9544:WNT9A
gene id: 9544:WNT9A
uniprot id: A0A1D5Q746
uniprot id: A0A5F8AIA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9544:PDP2
gene id: 9544:PDP2
uniprot id: A0A8J8XKI8
uniprot id: F6VCV0
names: Similarity
messages: Belongs to the PP2C family.

9544:RDH11
gene id: 9544:RDH11
uniprot id: A0A8J8XYK8
uniprot id: H9Z9L2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:PCYOX1L
gene id: 9544:PCYOX1L
uniprot id: F7F5G4
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9544:NPM1
gene id: 9544:NPM1
uniprot id: F7AWI0
uniprot id: F7AWJ2
names: Similarity
messages: Belongs to the nucleoplasmin family.

9544:DSCC1
gene id: 9544:DSCC1
uniprot id: F7H261
names: Similarity
messages: Belongs to the DCC1 family.

9544:LCK
gene id: 9544:LCK
uniprot id: A0A1D5Q9I1
uniprot id: G7MI89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9544:RPA2
gene id: 9544:RPA2
uniprot id: I0FU12
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

9544:GAR1
gene id: 9544:GAR1
uniprot id: A0A5K1VBP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9544:STEAP4
gene id: 9544:STEAP4
uniprot id: F7GSM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9544:SUCLG1
gene id: 9544:SUCLG1
uniprot id: A0A8J8YNS2
uniprot id: G7NAH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9544:RGS5
gene id: 9544:RGS5
uniprot id: I0FVT2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9544:DPH1
gene id: 9544:DPH1
uniprot id: A0A5F8A8F3
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.

9544:EPO
gene id: 9544:EPO
uniprot id: F6WN92
uniprot id: Q28513
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
messages: Secreted

9544:OAS3
gene id: 9544:OAS3
uniprot id: A0A1D5QJ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9544:TRAPPC13
gene id: 9544:TRAPPC13
uniprot id: F6WE11
uniprot id: H9G007
uniprot id: H9Z077
uniprot id: H9Z078
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9544:SYT1
gene id: 9544:SYT1
uniprot id: A0A5F8AJ31
uniprot id: A0A8J8YQG8
uniprot id: F7GFB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9544:NEU1
gene id: 9544:NEU1
uniprot id: A0A8J8YRG4
uniprot id: F7EZS0
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9544:MEX3B
gene id: 9544:MEX3B
uniprot id: F7ACW6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9544:GOSR1
gene id: 9544:GOSR1
uniprot id: A0A5K1TXI0
uniprot id: H9G254
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9544:RBM12
gene id: 9544:RBM12
uniprot id: Q8SQ27
names: Subcellular Location Annotation
messages: Nucleus

9544:PLCD1
gene id: 9544:PLCD1
uniprot id: A0A8J8XPQ2
uniprot id: G7MJ18
uniprot id: I0FHZ5
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9544:ST3GAL4
gene id: 9544:ST3GAL4
uniprot id: F7EUG5
uniprot id: H9FYK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9544:LOC714349
gene id: 9544:LOC714349
uniprot id: F7HGB1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9544:PEBP1
gene id: 9544:PEBP1
uniprot id: F5CI18
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9544:HIST1H2BH
gene id: 9544:HIST1H2BH
uniprot id: A0A1D5RGX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9544:SOST
gene id: 9544:SOST
uniprot id: A0A8J8YL84
uniprot id: F6WYL4
names: Similarity
messages: Belongs to the sclerostin family.

9544:GFRA1
gene id: 9544:GFRA1
uniprot id: A0A5F7Z995
uniprot id: F7GPD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9544:SEPTIN3
gene id: 9544:SEPTIN3
uniprot id: A0A5K1UFL5
uniprot id: G7N430
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9544:CMTM8
gene id: 9544:CMTM8
uniprot id: A0A1D5R690
uniprot id: A0A8J8XTE8
names: Subcellular Location Annotation
messages: Membrane

9544:STEAP3
gene id: 9544:STEAP3
uniprot id: A0A1D5R0G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9544:NPC1L1
gene id: 9544:NPC1L1
uniprot id: A0MJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9544:NSUN6
gene id: 9544:NSUN6
uniprot id: H9EW86
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9544:SLC9A4
gene id: 9544:SLC9A4
uniprot id: F6XBB3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9544:MTFR1L
gene id: 9544:MTFR1L
uniprot id: F7BDG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9544:ABCB1
gene id: 9544:ABCB1
uniprot id: Q8HZQ7
names: Subcellular Location Annotation
messages: Membrane

9544:TBCE
gene id: 9544:TBCE
uniprot id: A0A8J8YD04
uniprot id: G7MFP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

9544:SDHB
gene id: 9544:SDHB
uniprot id: F7GTK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9544:AXIN1
gene id: 9544:AXIN1
uniprot id: A0A5F7ZYG4
uniprot id: F6Y8U0
names: Subcellular Location Annotation
messages: Cytoplasm

9544:FAM120A
gene id: 9544:FAM120A
uniprot id: H9FRU7
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9544:VASP
gene id: 9544:VASP
uniprot id: I0FG82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9544:RALYL
gene id: 9544:RALYL
uniprot id: A0A1D5R9N5
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9544:NAPG
gene id: 9544:NAPG
uniprot id: H9ZEU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9544:PCSK4
gene id: 9544:PCSK4
uniprot id: F6VEN2
names: Similarity
messages: Belongs to the peptidase S8 family.

9544:AQP2
gene id: 9544:AQP2
uniprot id: A0A8J8Y3U6
uniprot id: F6W6H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9544:RBM48
gene id: 9544:RBM48
uniprot id: A0A8J8Y701
uniprot id: F6RN96
names: Function
names: Similarity
names: Subunit
messages: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: Belongs to the RBM48 family.
messages: Component of the minor spliceosome. Within this complex, interacts with ARMC7 and PRPF8/PRP8.

9544:VPS26B
gene id: 9544:VPS26B
uniprot id: H9ENV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9544:TMEM230
gene id: 9544:TMEM230
uniprot id: F6R010
uniprot id: F6ZD79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9544:IL2RA
gene id: 9544:IL2RA
uniprot id: Q5MNY4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9544:KRT12
gene id: 9544:KRT12
uniprot id: G7NIA1
names: Similarity
messages: Belongs to the intermediate filament family.

9544:HP
gene id: 9544:HP
uniprot id: H9Z8D4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta chains; disulfide-linked (By similarity). The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers (By similarity). Interacts with CD163 (By similarity). Interacts with ERGIC3.

9544:CNOT9
gene id: 9544:CNOT9
uniprot id: A0A8J8XNV8
uniprot id: F6U8W4
uniprot id: G7N8X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9544:MAP2
gene id: 9544:MAP2
uniprot id: A0A1D5R639
uniprot id: F6Y370
uniprot id: G7N8T0
uniprot id: I2CXY8
names: Subcellular Location Annotation
messages: cytoskeleton

9544:RPL19
gene id: 9544:RPL19
uniprot id: F7A9N0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9544:ARL8A
gene id: 9544:ARL8A
uniprot id: H9Z596
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: axon
messages: spindle

9544:PPEF1
gene id: 9544:PPEF1
uniprot id: A0A8J8Y171
uniprot id: F7C4V6
names: Similarity
messages: Belongs to the PPP phosphatase family.

9544:PEX19
gene id: 9544:PEX19
uniprot id: H9ERK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9544:POGLUT2
gene id: 9544:POGLUT2
uniprot id: H9FZN8
names: Similarity
messages: Belongs to the KDELC family.

9544:IL1A
gene id: 9544:IL1A
uniprot id: P48089
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated within its nuclear localization sequence, which impacts subcellular localization.
messages: Belongs to the IL-1 family.
messages: Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
messages: Cytoplasm
messages: Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.
messages: Nucleus
messages: Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.
messages: Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.
messages: Secreted
messages: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

9544:VPS4B
gene id: 9544:VPS4B
uniprot id: A0A8J8XMF8
uniprot id: F7H6D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9544:TARBP2
gene id: 9544:TARBP2
uniprot id: G7N752
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9544:HSD17B13
gene id: 9544:HSD17B13
uniprot id: A0A8J8YRE2
uniprot id: G7MTC9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9544:TAAR4
gene id: 9544:TAAR4
uniprot id: A5JMD1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9544:CA11
gene id: 9544:CA11
uniprot id: A0A8J8YFL5
uniprot id: H9ER59
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9544:GNA11
gene id: 9544:GNA11
uniprot id: F7GZP9
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9544:HGF
gene id: 9544:HGF
uniprot id: F7A5G3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9544:DCST2
gene id: 9544:DCST2
uniprot id: F7EGN2
names: Subcellular Location Annotation
messages: Membrane

9544:LOC694628
gene id: 9544:LOC694628
uniprot id: A0A1D5RJ95
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9544:CTSK
gene id: 9544:CTSK
uniprot id: A0A8J8YGW4
uniprot id: G7MDI3
uniprot id: P61277
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Secreted
messages: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

9544:HYLS1
gene id: 9544:HYLS1
uniprot id: A0A8J8XP53
uniprot id: I0FL28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

9544:SLC40A1
gene id: 9544:SLC40A1
uniprot id: A0A5F8AQS1
uniprot id: A0A8J8XGY3
uniprot id: G7N8H6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

9544:DYNC1H1
gene id: 9544:DYNC1H1
uniprot id: F6VUB3
names: Similarity
messages: Belongs to the dynein heavy chain family.

9544:NPAS1
gene id: 9544:NPAS1
uniprot id: F6VP46
names: Subcellular Location Annotation
messages: Nucleus

9544:LMX1A
gene id: 9544:LMX1A
uniprot id: A0A8J8XGP5
uniprot id: F7B132
names: Subcellular Location Annotation
messages: Nucleus

9544:RAB18
gene id: 9544:RAB18
uniprot id: A0A1D5RB55
uniprot id: F7EUM0
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9544:RMND1
gene id: 9544:RMND1
uniprot id: F7H660
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9544:TNFAIP1
gene id: 9544:TNFAIP1
uniprot id: A0A8J8XLT6
uniprot id: H9FZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9544:TAS2R10
gene id: 9544:TAS2R10
uniprot id: A0A5F7ZGJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9544:ATP5F1E
gene id: 9544:ATP5F1E
uniprot id: A0A8J8YGG2
uniprot id: Q6VEU4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9544:CPEB1
gene id: 9544:CPEB1
uniprot id: A0A1D5R0L8
names: Similarity
messages: Belongs to the RRM CPEB family.

9544:MYCBP2
gene id: 9544:MYCBP2
uniprot id: F7E6Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RING-Cys relay (RCR) family.
messages: axon

9544:ETFB
gene id: 9544:ETFB
uniprot id: H9ETC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9544:CADM2
gene id: 9544:CADM2
uniprot id: H9ENT6
names: Similarity
messages: Belongs to the nectin family.

9544:TCTA
gene id: 9544:TCTA
uniprot id: A0A8J8YR35
uniprot id: F7DH74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9544:PDGFRA
gene id: 9544:PDGFRA
uniprot id: A0A8J8YH90
uniprot id: G7MTB0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9544:NUP155
gene id: 9544:NUP155
uniprot id: A0A1D5QL31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.
messages: nuclear pore complex

9544:FOXA3
gene id: 9544:FOXA3
uniprot id: A0A8J8YKH7
uniprot id: G7NMZ5
names: Subcellular Location Annotation
messages: Nucleus

9544:MAGI1
gene id: 9544:MAGI1
uniprot id: F6V3H6
names: Subcellular Location Annotation
messages: Membrane

9544:SLC22A3
gene id: 9544:SLC22A3
uniprot id: F6TY97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Cell membrane

9544:CXCR6
gene id: 9544:CXCR6
uniprot id: F7BTV1
uniprot id: H9Z4H8
uniprot id: Q9XT45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

9544:ATG9A
gene id: 9544:ATG9A
uniprot id: A0A8J8XUD8
uniprot id: F7B1E9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9544:ATP5F1D
gene id: 9544:ATP5F1D
uniprot id: F7ERL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

9544:KCNA2
gene id: 9544:KCNA2
uniprot id: A0A8J8Y0A0
uniprot id: G7MIG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

9544:UGT3A2
gene id: 9544:UGT3A2
uniprot id: F7EZI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9544:SYT17
gene id: 9544:SYT17
uniprot id: F7G138
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9544:CHPF
gene id: 9544:CHPF
uniprot id: H9ESG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9544:HOXA10
gene id: 9544:HOXA10
uniprot id: F6YAI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9544:CCT5
gene id: 9544:CCT5
uniprot id: A0A1D5Q8I4
uniprot id: A0A8J8XLB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9544:ATRN
gene id: 9544:ATRN
uniprot id: F6X837
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:PEX3
gene id: 9544:PEX3
uniprot id: A0A8J8Y698
uniprot id: G7MQ77
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9544:BTN2A2
gene id: 9544:BTN2A2
uniprot id: H9Z4A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Cytoplasm
messages: Membrane

9544:BRINP1
gene id: 9544:BRINP1
uniprot id: A0A8J8XCJ2
uniprot id: F7HMK5
names: Similarity
messages: Belongs to the BRINP family.

9544:PGAP1
gene id: 9544:PGAP1
uniprot id: H9EWD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9544:GABRA1
gene id: 9544:GABRA1
uniprot id: A0A8J8YB45
uniprot id: F6VPP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:HCRTR2
gene id: 9544:HCRTR2
uniprot id: A0A8J8XMM4
uniprot id: F7CZM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:CLUAP1
gene id: 9544:CLUAP1
uniprot id: A0A5F8AP72
uniprot id: F6RR79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9544:SART1
gene id: 9544:SART1
uniprot id: H9G1L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

9544:EREG
gene id: 9544:EREG
uniprot id: A0A8J8XDA6
uniprot id: F7D8Y3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:KHDC1
gene id: 9544:KHDC1
uniprot id: F6YLS6
names: Similarity
messages: Belongs to the KHDC1 family.

9544:UBLCP1
gene id: 9544:UBLCP1
uniprot id: F6VI02
names: Subcellular Location Annotation
messages: Nucleus

9544:CRYBB2
gene id: 9544:CRYBB2
uniprot id: F7FCM9
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9544:TNFRSF1A
gene id: 9544:TNFRSF1A
uniprot id: A0A8J8XFE9
uniprot id: G7N5L8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9544:MAP3K5
gene id: 9544:MAP3K5
uniprot id: I0FRT6
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9544:GNAO1
gene id: 9544:GNAO1
uniprot id: A0A5F7ZR76
uniprot id: F7GQC5
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:LZTS2
gene id: 9544:LZTS2
uniprot id: F7AYC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

9544:CRY1
gene id: 9544:CRY1
uniprot id: A0A8J8Y596
uniprot id: F7ENG9
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

9544:BORCS7
gene id: 9544:BORCS7
uniprot id: A0A8J8XFC6
uniprot id: G7N115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Lysosome membrane
messages: Membrane

9544:GNAI2
gene id: 9544:GNAI2
uniprot id: A0A8J8XXB1
uniprot id: I0FJU1
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9544:BAK1
gene id: 9544:BAK1
uniprot id: H9H3A9
names: Similarity
messages: Belongs to the Bcl-2 family.

9544:FOXD3
gene id: 9544:FOXD3
uniprot id: F6ZBY1
names: Subcellular Location Annotation
messages: Nucleus

9544:FAM160A2
gene id: 9544:FAM160A2
uniprot id: A0A8J8YSH1
uniprot id: F7BPS8
uniprot id: H9YYB8
names: Similarity
messages: Belongs to the FHIP family.

9544:MRPL14
gene id: 9544:MRPL14
uniprot id: F7B3S2
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9544:ATP2A2
gene id: 9544:ATP2A2
uniprot id: H9FUZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9544:NIFK
gene id: 9544:NIFK
uniprot id: A0A8J8Y767
uniprot id: G7NB31
names: Subcellular Location Annotation
messages: nucleolus

9544:UCP3
gene id: 9544:UCP3
uniprot id: A0A8J8XZD1
uniprot id: F6RHP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9544:HK2
gene id: 9544:HK2
uniprot id: A0A5F8A8Z5
uniprot id: A0A8J8Y0W5
names: Similarity
messages: Belongs to the hexokinase family.

9544:GBF1
gene id: 9544:GBF1
uniprot id: F7GVX8
names: Subcellular Location Annotation
messages: Golgi apparatus

9544:NDEL1
gene id: 9544:NDEL1
uniprot id: A0A5F8ASX0
uniprot id: F6UAG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9544:SMAD1
gene id: 9544:SMAD1
uniprot id: A0A8J8XS88
uniprot id: F7GZM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9544:P4HB
gene id: 9544:P4HB
uniprot id: H9FV20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9544:SAMD4B
gene id: 9544:SAMD4B
uniprot id: A0A8J8XKG0
uniprot id: G7NNK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9544:PPP1R18
gene id: 9544:PPP1R18
uniprot id: Q5TM66
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with Protein phosphatase 1 (PP1).
messages: May target protein phosphatase 1 to F-actin cytoskeleton.
messages: cytoskeleton

9544:CCN3
gene id: 9544:CCN3
uniprot id: A0A8J8Y4E9
uniprot id: F6WCM6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9544:UBE4A
gene id: 9544:UBE4A
uniprot id: H9G1Y1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

9544:ANKRD13B
gene id: 9544:ANKRD13B
uniprot id: F7BQ46
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9544:WDR12
gene id: 9544:WDR12
uniprot id: H9FX18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9544:OR51M1
gene id: 9544:OR51M1
uniprot id: A0A5F7Z9J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9544:STK38L
gene id: 9544:STK38L
uniprot id: F7E684
names: Similarity
messages: Belongs to the protein kinase superfamily.

9544:NTN4
gene id: 9544:NTN4
uniprot id: F7A3Z5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9544:HECTD1
gene id: 9544:HECTD1
uniprot id: A0A5F8AKA2
uniprot id: H9FSK0
uniprot id: H9FSK1
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

9544:CYB5B
gene id: 9544:CYB5B
uniprot id: H9G062
names: Similarity
messages: Belongs to the cytochrome b5 family.

9544:GATA2
gene id: 9544:GATA2
uniprot id: F6VIP3
names: Subcellular Location Annotation
messages: Nucleus

9544:CHRNA9
gene id: 9544:CHRNA9
uniprot id: F7F3G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9544:RAMP3
gene id: 9544:RAMP3
uniprot id: F7HCG7
names: Similarity
messages: Belongs to the RAMP family.