9541:PPM1F
gene id: 9541:PPM1F
uniprot id: A0A7N9D1S3
names: Similarity
messages: Belongs to the PP2C family.

9541:RPS13
gene id: 9541:RPS13
uniprot id: A0A2K5V043
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9541:TMEM265
gene id: 9541:TMEM265
uniprot id: A0A2K5WDS6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:CFHR2
gene id: 9541:CFHR2
uniprot id: A0A2K5WEE7
uniprot id: G8F5N7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:DYNC1I1
gene id: 9541:DYNC1I1
uniprot id: A0A2K5TPG5
uniprot id: A0A2K5TSB8
uniprot id: A0A2K5TSF5
uniprot id: A0A8J8XIW1
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9541:GTF2H2
gene id: 9541:GTF2H2
uniprot id: A0A2K5U6X1
uniprot id: G7P7P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9541:ANP32A
gene id: 9541:ANP32A
uniprot id: I7GHD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9541:TSPAN5
gene id: 9541:TSPAN5
uniprot id: A0A7N9DCS4
uniprot id: A0A8J8Y6H9
uniprot id: G7P5Y5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:RIOK1
gene id: 9541:RIOK1
uniprot id: A0A8J8YEB8
uniprot id: G7P4D1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9541:CYRIA
gene id: 9541:CYRIA
uniprot id: A0A8J8XXW2
uniprot id: G7PLN0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9541:SSBP1
gene id: 9541:SSBP1
uniprot id: A0A7N9C9N4
uniprot id: A0A8J8XDD0
uniprot id: G7P1E9
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9541:MPV17
gene id: 9541:MPV17
uniprot id: A0A2K5W873
uniprot id: G7PLV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9541:ACAD8
gene id: 9541:ACAD8
uniprot id: A0A2K5WP11
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9541:FZD6
gene id: 9541:FZD6
uniprot id: A0A2K5U727
uniprot id: A0A8J8YDW8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:FDFT1
gene id: 9541:FDFT1
uniprot id: A0A2K5W905
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9541:ACVRL1
gene id: 9541:ACVRL1
uniprot id: A0A2K5WXU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:GRIA3
gene id: 9541:GRIA3
uniprot id: A0A2K5UF45
uniprot id: A0A2K5UFB7
uniprot id: A0A8J8YCD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:EXOC8
gene id: 9541:EXOC8
uniprot id: A0A2K5WXX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9541:ZFPM2
gene id: 9541:ZFPM2
uniprot id: A0A2K5TLG1
uniprot id: A0A2K5TLG8
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102145217
gene id: 9541:LOC102145217
uniprot id: A0A2K5W9B8
names: Similarity
messages: Belongs to the ATG8 family.

9541:AQP2
gene id: 9541:AQP2
uniprot id: A0A7N9CSL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9541:MMAA
gene id: 9541:MMAA
uniprot id: A0A2K5V0N3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

9541:ISOC1
gene id: 9541:ISOC1
uniprot id: A0A2K5VIT7
names: Similarity
messages: Belongs to the isochorismatase family.

9541:WEE1
gene id: 9541:WEE1
uniprot id: Q95JK5
names: Cofactor
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Binds 2 magnesium ions per subunit.

9541:SLITRK4
gene id: 9541:SLITRK4
uniprot id: A0A2K5UMT4
names: Similarity
messages: Belongs to the SLITRK family.

9541:TMEM176A
gene id: 9541:TMEM176A
uniprot id: A0A8J8Y9M3
uniprot id: G7P209
names: Similarity
messages: Belongs to the TMEM176 family.

9541:ZEB1
gene id: 9541:ZEB1
uniprot id: A0A2K5W193
uniprot id: A0A2K5W1B1
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9541:PPP2R2B
gene id: 9541:PPP2R2B
uniprot id: A0A158SIQ6
uniprot id: A0A2K5U1Q0
uniprot id: A0A2K5U1Q5
uniprot id: A0A2K5U1U5
uniprot id: G7P8L1
uniprot id: Q4R8L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Cytoplasm
messages: Membrane
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TOMM22 (By similarity). Interacts with IER5 (via N- and C-terminal regions) (By similarity).
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
messages: cytoskeleton

9541:HECTD1
gene id: 9541:HECTD1
uniprot id: A0A2K5WKG5
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

9541:LSM1
gene id: 9541:LSM1
uniprot id: A0A2K5V3J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9541:GNG10
gene id: 9541:GNG10
uniprot id: A0A2K5WY75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:LOC102133286
gene id: 9541:LOC102133286
uniprot id: A0A8J8XD17
uniprot id: G7Q3A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9541:KRT81
gene id: 9541:KRT81
uniprot id: A0A2K5WWC1
names: Similarity
messages: Belongs to the intermediate filament family.

9541:MRPL52
gene id: 9541:MRPL52
uniprot id: A0A2K5X932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9541:MMP12
gene id: 9541:MMP12
uniprot id: A0A8J8YBR3
uniprot id: G7PNK7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9541:BEX2
gene id: 9541:BEX2
uniprot id: A0A2K5X340
uniprot id: G7Q3C0
names: Similarity
messages: Belongs to the BEX family.

9541:PPARGC1A
gene id: 9541:PPARGC1A
uniprot id: A0A2K5X8F0
uniprot id: A0A2K5X8W4
names: Subcellular Location Annotation
messages: PML body

9541:PARP6
gene id: 9541:PARP6
uniprot id: A0A2K5X7T5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9541:SRPX2
gene id: 9541:SRPX2
uniprot id: A0A2K5VS42
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SCUBE3
gene id: 9541:SCUBE3
uniprot id: A0A2K5VBW0
uniprot id: A0A7N9DF80
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:SLC35E3
gene id: 9541:SLC35E3
uniprot id: A0A2K5VC19
names: Subcellular Location Annotation
messages: Membrane

9541:BECN1
gene id: 9541:BECN1
uniprot id: A0A2K5V238
uniprot id: A0A2K5V263
uniprot id: A0A2K5V2A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9541:MRPS18C
gene id: 9541:MRPS18C
uniprot id: A0A2K5WDE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9541:PFKFB3
gene id: 9541:PFKFB3
uniprot id: A0A2K5V967
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9541:ENTPD3
gene id: 9541:ENTPD3
uniprot id: A0A2K5VC94
uniprot id: A0A2K5VCB1
uniprot id: G7NYI6
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9541:CNOT8
gene id: 9541:CNOT8
uniprot id: A0A2K5W640
uniprot id: A0A8J8YH65
uniprot id: G7P6Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9541:B3GALNT1
gene id: 9541:B3GALNT1
uniprot id: A0A7N9ICJ4
uniprot id: A0A8J8XWK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:C19H19orf12
gene id: 9541:C19H19orf12
uniprot id: A0A7N9D9S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

9541:PRTFDC1
gene id: 9541:PRTFDC1
uniprot id: A0A2K5WY00
uniprot id: A0A2K5WYI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9541:PDK4
gene id: 9541:PDK4
uniprot id: A0A2K5UB94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9541:HYLS1
gene id: 9541:HYLS1
uniprot id: G7PPM8
uniprot id: Q4R2Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: Cytoplasm
messages: Plays a role in ciliogenesis.
messages: centriole
messages: cilium

9541:POLR1B
gene id: 9541:POLR1B
uniprot id: A0A2K5V5H3
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9541:BMPR2
gene id: 9541:BMPR2
uniprot id: A0A2K5V0S9
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9541:SLC35A5
gene id: 9541:SLC35A5
uniprot id: A0A2K5VYJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:EMSY
gene id: 9541:EMSY
uniprot id: A0A2K5VWJ6
uniprot id: A0A2K5VWT6
uniprot id: A0A8J8YMX9
uniprot id: G7PNA3
names: Subcellular Location Annotation
messages: Nucleus

9541:RPS12
gene id: 9541:RPS12
uniprot id: A0A8J8YCC6
uniprot id: G7P346
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9541:MFSD8
gene id: 9541:MFSD8
uniprot id: A0A2K5VAW8
uniprot id: A0A2K5VB08
uniprot id: G8F4L8
names: Subcellular Location Annotation
messages: Membrane

9541:MOB3B
gene id: 9541:MOB3B
uniprot id: A0A8J8YK25
uniprot id: G7PS66
names: Similarity
messages: Belongs to the MOB1/phocein family.

9541:SBDS
gene id: 9541:SBDS
uniprot id: A0A2K5V3B1
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9541:LOC102126915
gene id: 9541:LOC102126915
uniprot id: A0A2K5UK87
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:BTG1
gene id: 9541:BTG1
uniprot id: A0A7N9CIC1
names: Similarity
messages: Belongs to the BTG family.

9541:RBBP4
gene id: 9541:RBBP4
uniprot id: A0A7N9D3U8
names: Subcellular Location Annotation
messages: Nucleus

9541:API5
gene id: 9541:API5
uniprot id: A0A2K5WJH3
names: Similarity
messages: Belongs to the API5 family.

9541:CARMIL1
gene id: 9541:CARMIL1
uniprot id: A0A2K5WNM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9541:PFKFB2
gene id: 9541:PFKFB2
uniprot id: A0A2K5VX43
uniprot id: G7NUP7
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9541:TP53I11
gene id: 9541:TP53I11
uniprot id: A0A7N9CI61
names: Subcellular Location Annotation
messages: Membrane

9541:TPMT
gene id: 9541:TPMT
uniprot id: A0A2K5V568
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Monomer.

9541:RPLP1
gene id: 9541:RPLP1
uniprot id: A0A2K5X6Z8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9541:MDK
gene id: 9541:MDK
uniprot id: A0A2K5UAU4
names: Similarity
messages: Belongs to the pleiotrophin family.

9541:PDE7B
gene id: 9541:PDE7B
uniprot id: A0A2K5V537
uniprot id: A0A2K5V567
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:VEGFD
gene id: 9541:VEGFD
uniprot id: A0A8J8Y018
uniprot id: G7Q297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9541:SPOPL
gene id: 9541:SPOPL
uniprot id: A0A2K5TT09
uniprot id: A0A8J8YI43
names: Similarity
messages: Belongs to the Tdpoz family.

9541:NME7
gene id: 9541:NME7
uniprot id: A0A2K5X5S7
uniprot id: A0A7N9CSI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9541:VWC2L
gene id: 9541:VWC2L
uniprot id: A0A2K5UC09
uniprot id: A0A8J8YL83
names: Subcellular Location Annotation
messages: Synapse

9541:SAR1A
gene id: 9541:SAR1A
uniprot id: A0A2K5WYE8
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9541:LOC102145245
gene id: 9541:LOC102145245
uniprot id: A0A2K5TZ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9541:ABCB8
gene id: 9541:ABCB8
uniprot id: A0A2K5TL14
uniprot id: A0A8J8Y2Y8
uniprot id: G7P213
names: Subcellular Location Annotation
messages: Membrane

9541:NFE2
gene id: 9541:NFE2
uniprot id: A0A2K5VKY3
uniprot id: G8F5B9
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9541:GALNT14
gene id: 9541:GALNT14
uniprot id: A0A7N9C9A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:LOC102133222
gene id: 9541:LOC102133222
uniprot id: A0A2K5X5I7
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9541:CXCR6
gene id: 9541:CXCR6
uniprot id: A0A2K5X6U6
uniprot id: A0A7N9DCG8
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

9541:LOC102123623
gene id: 9541:LOC102123623
uniprot id: A0A2K5URR0
uniprot id: A0A7N9CR01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9541:LOC102127733
gene id: 9541:LOC102127733
uniprot id: A0A2K5UJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:DNAI7
gene id: 9541:DNAI7
uniprot id: A0A2K5UZS8
names: Similarity
messages: Belongs to the DNAI7 family.

9541:NXT1
gene id: 9541:NXT1
uniprot id: A0A2K5UHH8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9541:ZDHHC21
gene id: 9541:ZDHHC21
uniprot id: A0A8J8YKM8
uniprot id: G7PSC3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:POU5F1
gene id: 9541:POU5F1
uniprot id: A0A2K5UC29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9541:LOC102127391
gene id: 9541:LOC102127391
uniprot id: A0A2K5UCG6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:PRR15L
gene id: 9541:PRR15L
uniprot id: A0A2K5UP02
names: Similarity
messages: Belongs to the PRR15 family.

9541:SHCBP1
gene id: 9541:SHCBP1
uniprot id: A0A2K5WEF9
names: Subcellular Location Annotation
messages: spindle

9541:ANXA3
gene id: 9541:ANXA3
uniprot id: A0A2K5W7S4
uniprot id: A0A8J8XSE0
uniprot id: G7P536
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9541:IL2RB
gene id: 9541:IL2RB
uniprot id: Q38J85
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Cell surface
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation (By similarity).
messages: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.

9541:LALBA
gene id: 9541:LALBA
uniprot id: A0A8J8YQW7
uniprot id: G7PHQ9
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9541:RNF7
gene id: 9541:RNF7
uniprot id: A0A7N9CCY2
names: Similarity
messages: Belongs to the RING-box family.

9541:MEP1A
gene id: 9541:MEP1A
uniprot id: A0A2K5TPQ3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PPP4R3A
gene id: 9541:PPP4R3A
uniprot id: A0A2K5UC63
names: Similarity
messages: Belongs to the SMEK family.

9541:PAH
gene id: 9541:PAH
uniprot id: A0A2K5W2M4
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9541:PPIL4
gene id: 9541:PPIL4
uniprot id: A0A2K5V405
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9541:HIGD1A
gene id: 9541:HIGD1A
uniprot id: A0A8J8YGQ2
uniprot id: G7NY64
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9541:PGPEP1
gene id: 9541:PGPEP1
uniprot id: A0A7N9CFL0
uniprot id: A0A8J8Y4Q6
uniprot id: G7PWZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

9541:CCSER2
gene id: 9541:CCSER2
uniprot id: A0A2K5VYN7
uniprot id: A0A2K5VYP3
uniprot id: A0A2K5VYQ5
uniprot id: A0A8J8XAJ5
names: Similarity
messages: Belongs to the CCSER family.

9541:MLC1
gene id: 9541:MLC1
uniprot id: Q60HE7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Interacts with ATP1B1. Part of a complex containing ATP1B1, TRPV4, AQP4 and HEPACAM.
messages: Membrane
messages: Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.
messages: perinuclear region

9541:MAS1
gene id: 9541:MAS1
uniprot id: A0A2K5UBY9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:DUSP10
gene id: 9541:DUSP10
uniprot id: A0A8J8XX38
uniprot id: G7NTY0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9541:AZIN2
gene id: 9541:AZIN2
uniprot id: A0A2K5V2C9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9541:MAPK10
gene id: 9541:MAPK10
uniprot id: A0A2K5TUM6
uniprot id: A0A2K5TVL4
uniprot id: G7P5U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9541:EXOC7
gene id: 9541:EXOC7
uniprot id: A0A2K5UAR9
uniprot id: A0A2K5UAV8
uniprot id: A0A2K5UB16
uniprot id: A0A2K5UB38
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9541:TNPO2
gene id: 9541:TNPO2
uniprot id: A0A2K5TSA9
names: Subcellular Location Annotation
messages: Cytoplasm

9541:ANKRD34B
gene id: 9541:ANKRD34B
uniprot id: A0A8J8XFW9
uniprot id: G7P7V3
names: Similarity
messages: Belongs to the ANKRD34 family.

9541:CACFD1
gene id: 9541:CACFD1
uniprot id: A0A2K5TNB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

9541:CHMP2A
gene id: 9541:CHMP2A
uniprot id: A0A8J8XJE1
uniprot id: G7PZC8
names: Similarity
messages: Belongs to the SNF7 family.

9541:ZNF174
gene id: 9541:ZNF174
uniprot id: A0A2K5UK10
names: Subcellular Location Annotation
messages: Nucleus

9541:CBLL1
gene id: 9541:CBLL1
uniprot id: Q4R7I8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Hakai family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.
messages: Homodimer. Interacts with tyrosine-phosphorylated SRC substrates. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of METTL3 and METTL14. The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (By similarity). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (By similarity).
messages: Nucleus speckle
messages: Phosphorylated on tyrosine residues.
messages: The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.
messages: nucleoplasm

9541:UNC45A
gene id: 9541:UNC45A
uniprot id: A0A2K5W2E7
names: Subcellular Location Annotation
messages: perinuclear region

9541:ZSCAN21
gene id: 9541:ZSCAN21
uniprot id: A0A8J8XYU1
uniprot id: G7P0C2
names: Subcellular Location Annotation
messages: Nucleus

9541:SLC27A2
gene id: 9541:SLC27A2
uniprot id: A0A2K5X2A2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:STAT2
gene id: 9541:STAT2
uniprot id: A0A2K5W5J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9541:CCND2
gene id: 9541:CCND2
uniprot id: A0A8J8YNL4
uniprot id: G7PJL4
names: Similarity
messages: Belongs to the cyclin family.

9541:ASZ1
gene id: 9541:ASZ1
uniprot id: A0A2K5U3L9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9541:FAM199X
gene id: 9541:FAM199X
uniprot id: A0A2K5X7I9
names: Similarity
messages: Belongs to the FAM199 family.

9541:KCTD20
gene id: 9541:KCTD20
uniprot id: A0A2K5V6B5
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SLC2A5
gene id: 9541:SLC2A5
uniprot id: A0A7N9IEN2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Membrane
messages: sarcolemma

9541:SLC24A4
gene id: 9541:SLC24A4
uniprot id: A0A2K5WJQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9541:CDK1
gene id: 9541:CDK1
uniprot id: A0A2K5X3E5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:CCR8
gene id: 9541:CCR8
uniprot id: A0A8J8XUI3
uniprot id: G7NYJ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:RBPJ
gene id: 9541:RBPJ
uniprot id: A0A2K5TVV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9541:LZIC
gene id: 9541:LZIC
uniprot id: A0A2K5WIK2
uniprot id: G7NU54
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9541:PJVK
gene id: 9541:PJVK
uniprot id: A0A8J8YQB6
uniprot id: G7PKX8
names: Similarity
messages: Belongs to the gasdermin family.

9541:DLX4
gene id: 9541:DLX4
uniprot id: A0A2K5UFH5
names: Subcellular Location Annotation
messages: Nucleus

9541:S100A11
gene id: 9541:S100A11
uniprot id: A0A7N9CR25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

9541:URM1
gene id: 9541:URM1
uniprot id: A0A2K5UBC9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

9541:MMP20
gene id: 9541:MMP20
uniprot id: A0A2K5TT27
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9541:CORT
gene id: 9541:CORT
uniprot id: A0A2K5V9I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9541:RPL36
gene id: 9541:RPL36
uniprot id: A0A2K5WFN5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9541:DKK2
gene id: 9541:DKK2
uniprot id: A0A2K5V1Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9541:CPT2
gene id: 9541:CPT2
uniprot id: Q60HG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.
messages: Mitochondrion inner membrane

9541:PLEKHA8
gene id: 9541:PLEKHA8
uniprot id: G7P0H6
names: Subcellular Location Annotation
messages: trans-Golgi network membrane

9541:LOC101926433
gene id: 9541:LOC101926433
uniprot id: A0A2K5U698
uniprot id: A0A2K5U6B3
uniprot id: A0A2K5U6L3
uniprot id: P53601
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Amyloid-beta peptides are degraded by IDE.
messages: Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron (By similarity).
messages: Belongs to the APP family.
messages: Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1 and NUMB and DAB1 (By similarity). Binding to DAB1 inhibits its serine phosphorylation (By similarity). Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Also interacts with GPCR-like protein BPP, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts, through a C-terminal domain, with GNAO1. Amyloid-beta protein 42 binds CHRNA7 in hippocampal neurons (By similarity). Amyloid-beta associates with HADH2 (By similarity). Interacts with CPEB1, ANKS1B, TNFRSF21 and AGER (By similarity). Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; dimerization is enhanced in the presence of Cu(2+) ions. Can form homodimers; this is promoted by heparin binding (By similarity). Amyloid-beta protein 40 interacts with S100A9 (By similarity). CTF-alpha product of APP interacts with GSAP (By similarity). Isoform APP695 interacts with SORL1 (via N-terminal ectodomain); this interaction retains APP in the trans-Golgi network and reduces processing into soluble APP-alpha and amyloid-beta peptides (By similarity). Isoform APP770 interacts with SORL1 (By similarity). The C99 fragment also interacts with SORL1 (By similarity). Interacts with PLD3 (By similarity). Interacts with VDAC1 (By similarity). Interacts with NSG1; could regulate APP processing (By similarity). Amyloid-beta protein 42 interacts with FPR2 (By similarity). Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity). Interacts with LRRK2 (By similarity). Interacts (via cytoplasmic domain) with KIF5B (By similarity). Interacts (via C-terminus) with APB…
messages: Cell membrane
messages: Cell surface
messages: Chelation of metal ions, notably copper, iron and zinc, can induce histidine-bridging between amyloid-beta molecules resulting in amyloid-beta-metal aggregates. Extracellular zinc-binding increases binding of heparin to APP and inhibits collagen-binding.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity). Inhibits G(o)-alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N- and O-glycosylated.
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific. Phosphorylation can affect APP processing, neuronal differentiation and interaction with other proteins. Phosphorylated on Thr-743 in neuronal cells by Cdc5 kinase and Mapk10, in dividing cells by Cdc2 kinase in a cell-cycle dependent manner with maximal levels at the G2/M phase and, in vitro, by GSK-3-beta. The Thr-743 phosphorylated form causes a conformational change which reduces binding of Fe65 family members. In dopaminergic (DA) neurons, phosphorylation on Thr-743 by LRKK2 promotes the production and the nuclear translocation of the APP intracellular domain (AICD) which induces DA neuron apoptosis. Phosphorylation on Tyr-757 is required for SHC binding. Phosphorylated in the extracellular domain by casein kinases on both soluble and membrane-bound APP. This phosphorylation is inhibited by heparin.
messages: Proteolytically cleaved by caspases during neuronal apoptosis. Cleavage at Asp-739 by either caspase-3, -8 or -9 results in the production of the neurotoxic C31 peptide and the increased production of amyloid-beta peptides.
messages: Proteolytically processed under normal cellular conditions. Cleavage either by alpha-secretase, beta-secretase or theta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, and the retention of corresponding membrane-anchored C-terminal fragments, C80, C83 and C99. Subsequent processing of C80 and C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is non-amyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid-beta proteins, amyloid-beta protein 40 and amyloid-beta protein 42, major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59). PSEN1 cleavage is more efficient with C83 than with C99 as substrate (in vitro). Amyloid-beta protein 40 and Amyloid-beta protein 42 are cleaved by ACE. Many other minor amyloid-beta peptides, amyloid-beta 1-X peptides, are found in cerebral spinal fluid (CSF) including the amyloid-beta X-15 peptides, produced from the cleavage by alpha-secretase.
messages: Secreted
messages: Sulfated on tyrosine residues.
messages: The C-terminal region can bind zinc ions; this favors dimerization and formation of higher oligomers.
messages: The GFLD subdomain binds Cu(2+) ions; this promotes homodimerization.
messages: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The PID domain-containing proteins which bind APP require the YENPTY motif for full interaction. These interactions are independent of phosphorylation on the terminal tyrosine residue. The YENPXY site is also involved in clathrin-mediated endocytosis.
messages: The OX-2 motif shows some similarity to a region in the N-terminus of CD200/MOX2.
messages: The basolateral sorting signal (BaSS) is required for sorting of membrane proteins to the basolateral surface of epithelial cells.
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: The transmembrane helix undergoes a conformation change and unravels partially when bound to PSEN1, facilitating cleavage by PSEN1.
messages: Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP).
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9541:RNF170
gene id: 9541:RNF170
uniprot id: A0A2K5UWH0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:TBCC
gene id: 9541:TBCC
uniprot id: A0A2K5W8E9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9541:IGF2
gene id: 9541:IGF2
uniprot id: A0A2K5VND9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Secreted

9541:PICALM
gene id: 9541:PICALM
uniprot id: A0A2K5WE69
uniprot id: A0A2K5WEB3
uniprot id: A0A2K5WEK1
uniprot id: A0A2K5WES9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9541:SDE2
gene id: 9541:SDE2
uniprot id: A0A2K5UUP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

9541:POLR1A
gene id: 9541:POLR1A
uniprot id: A0A2K5WRU9
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9541:CD164
gene id: 9541:CD164
uniprot id: A0A2K5U496
uniprot id: A0A7N9C9R9
uniprot id: A0A7N9ID13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9541:LOC102128132
gene id: 9541:LOC102128132
uniprot id: A0A8J8YPI1
uniprot id: G7P1L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9541:LIPG
gene id: 9541:LIPG
uniprot id: A0A2K5TPF3
uniprot id: G8F3E1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:LOXL2
gene id: 9541:LOXL2
uniprot id: A0A2K5VWM8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9541:UCK2
gene id: 9541:UCK2
uniprot id: A0A2K5V3M5
names: Similarity
messages: Belongs to the uridine kinase family.

9541:SPATA20
gene id: 9541:SPATA20
uniprot id: A0A2K5VMY6
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

9541:RPF2
gene id: 9541:RPF2
uniprot id: A0A7N9CQC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

9541:NFU1
gene id: 9541:NFU1
uniprot id: A0A2K5V7D5
names: Similarity
messages: Belongs to the NifU family.

9541:SPECC1L
gene id: 9541:SPECC1L
uniprot id: A0A2K5UZ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9541:NKAIN3
gene id: 9541:NKAIN3
uniprot id: I7GNL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9541:DKK3
gene id: 9541:DKK3
uniprot id: Q4R4I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9541:ELK4
gene id: 9541:ELK4
uniprot id: A0A8J8YQ43
uniprot id: G7NVC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:KCTD6
gene id: 9541:KCTD6
uniprot id: A0A8J8YEU1
uniprot id: G7NZB5
names: Subcellular Location Annotation
messages: Cell membrane

9541:MTMR12
gene id: 9541:MTMR12
uniprot id: A0A2K5WJS6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9541:INSIG2
gene id: 9541:INSIG2
uniprot id: A0A2K5V608
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9541:TUB
gene id: 9541:TUB
uniprot id: A0A2K5UYI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9541:FOXN2
gene id: 9541:FOXN2
uniprot id: A0A8J8YI45
uniprot id: G7PM65
names: Subcellular Location Annotation
messages: Nucleus

9541:IL12RB1
gene id: 9541:IL12RB1
uniprot id: A0A2K5VWV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9541:HDAC1
gene id: 9541:HDAC1
uniprot id: A0A2K5U8T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9541:CALHM2
gene id: 9541:CALHM2
uniprot id: A0A2K5W6X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9541:ZBTB8OS
gene id: 9541:ZBTB8OS
uniprot id: A0A2K5V6L5
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

9541:SNRNP200
gene id: 9541:SNRNP200
uniprot id: A0A2K5X457
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9541:LOC102122521
gene id: 9541:LOC102122521
uniprot id: A0A8J8Y2C7
uniprot id: G7PWD9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9541:FHL5
gene id: 9541:FHL5
uniprot id: A0A8J8YGZ4
uniprot id: G7P427
uniprot id: Q4R7A4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity).
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9541:GDPD5
gene id: 9541:GDPD5
uniprot id: A0A2K5VDT2
uniprot id: A0A8J8YKA5
uniprot id: G7PN97
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9541:CCL20
gene id: 9541:CCL20
uniprot id: A0A2K5VMB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:TEX261
gene id: 9541:TEX261
uniprot id: A0A2K5VWR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9541:TPM4
gene id: 9541:TPM4
uniprot id: A0A2K5W0H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9541:PARVA
gene id: 9541:PARVA
uniprot id: A0A2K5TN80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: Membrane

9541:CASP5
gene id: 9541:CASP5
uniprot id: A0A2K5U1I1
names: Similarity
messages: Belongs to the peptidase C14A family.

9541:PFN4
gene id: 9541:PFN4
uniprot id: A0A8J8XVF5
uniprot id: G7PLR1
names: Similarity
messages: Belongs to the profilin family.

9541:SH3GLB1
gene id: 9541:SH3GLB1
uniprot id: A0A2K5VM88
uniprot id: A0A7N9D5S5
uniprot id: G7NTL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9541:CHMP1A
gene id: 9541:CHMP1A
uniprot id: A0A2K5WKS4
names: Similarity
messages: Belongs to the SNF7 family.

9541:CLDN20
gene id: 9541:CLDN20
uniprot id: A0A2K5UJE1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:ARF6
gene id: 9541:ARF6
uniprot id: G7PA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

9541:GINS1
gene id: 9541:GINS1
uniprot id: A0A2K5WLH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9541:TIMM9
gene id: 9541:TIMM9
uniprot id: A0A2K5TX31
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9541:LOC102133993
gene id: 9541:LOC102133993
uniprot id: A0A2K5WTV2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9541:SLC16A7
gene id: 9541:SLC16A7
uniprot id: A0A2K5U0D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9541:DUSP12
gene id: 9541:DUSP12
uniprot id: A0A8J8XMK3
uniprot id: G7NXC0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9541:CD200R1
gene id: 9541:CD200R1
uniprot id: A0A2K5WLW2
names: Similarity
messages: Belongs to the CD200R family.

9541:SERPINI1
gene id: 9541:SERPINI1
uniprot id: A0A8J8Y5L9
uniprot id: G7NZG9
names: Similarity
messages: Belongs to the serpin family.

9541:NXPH1
gene id: 9541:NXPH1
uniprot id: A0A8J8XG87
uniprot id: G7P1A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9541:MSN
gene id: 9541:MSN
uniprot id: A0A2K5WCE4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9541:MT3
gene id: 9541:MT3
uniprot id: G7Q160
uniprot id: Q2PFZ0
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity).
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9541:HOXC10
gene id: 9541:HOXC10
uniprot id: A0A2K5WZJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9541:GPR68
gene id: 9541:GPR68
uniprot id: A0A2K5UC27
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:GATA3
gene id: 9541:GATA3
uniprot id: A0A2K5W1K4
names: Subcellular Location Annotation
messages: Nucleus

9541:S100G
gene id: 9541:S100G
uniprot id: A0A2K5V3E4
names: Similarity
messages: Belongs to the S-100 family.

9541:STX6
gene id: 9541:STX6
uniprot id: A0A2K5V4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9541:LOC102124284
gene id: 9541:LOC102124284
uniprot id: A0A2K5UF72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9541:PPAT
gene id: 9541:PPAT
uniprot id: A0A8J8YHF4
uniprot id: G7P5S2
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9541:ACTL8
gene id: 9541:ACTL8
uniprot id: A0A8J8Y4N5
uniprot id: G7NUR7
names: Similarity
messages: Belongs to the actin family.

9541:TIPRL
gene id: 9541:TIPRL
uniprot id: A0A2K5VUG0
names: Similarity
messages: Belongs to the TIP41 family.

9541:PTP4A1
gene id: 9541:PTP4A1
uniprot id: Q9TSM6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome
messages: Endoplasmic reticulum
messages: Farnesylated. Farnesylation is required for membrane targeting (By similarity).
messages: Homotrimer. Interacts with ATF5 and tubulin (By similarity).
messages: In the retina, expressed by red/green- but not blue-sensitive cone photoreceptor cells, and by rod bipolar cells (at protein level).
messages: Inhibited by sodium orthovanadate and pentamidine.
messages: Nucleus
messages: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
messages: spindle

9541:VPS26B
gene id: 9541:VPS26B
uniprot id: A0A8J8XCF9
uniprot id: G7PPW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9541:LOC102125581
gene id: 9541:LOC102125581
uniprot id: G7P1K7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9541:BSX
gene id: 9541:BSX
uniprot id: A0A2K5TZ41
names: Subcellular Location Annotation
messages: Nucleus

9541:PPIB
gene id: 9541:PPIB
uniprot id: A0A2K5UAH0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9541:ATP5PF
gene id: 9541:ATP5PF
uniprot id: Q8SPH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9541:CEP19
gene id: 9541:CEP19
uniprot id: A0A7N9IDV7
uniprot id: A0A8J8XSK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9541:MRPL35
gene id: 9541:MRPL35
uniprot id: A0A7N9D929
uniprot id: G8F3R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9541:GCNT3
gene id: 9541:GCNT3
uniprot id: G7PBK8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9541:SLC25A44
gene id: 9541:SLC25A44
uniprot id: A0A8J8XAQ3
uniprot id: G7NV80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:SERPINA11
gene id: 9541:SERPINA11
uniprot id: A0A2K5VTE5
names: Similarity
messages: Belongs to the serpin family.

9541:SPTAN1
gene id: 9541:SPTAN1
uniprot id: A0A2K5VKZ4
uniprot id: A0A2K5VL04
uniprot id: A0A2K5VL65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9541:CSRNP3
gene id: 9541:CSRNP3
uniprot id: A0A2K5WL57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9541:ACADSB
gene id: 9541:ACADSB
uniprot id: Q4R4S2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9541:CDK11B
gene id: 9541:CDK11B
uniprot id: A0A2K5VNP7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9541:EVA1A
gene id: 9541:EVA1A
uniprot id: A0A2K5UI30
names: Similarity
messages: Belongs to the EVA1 family.

9541:YIPF2
gene id: 9541:YIPF2
uniprot id: A0A2K5X4R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9541:BRINP2
gene id: 9541:BRINP2
uniprot id: A0A2K5TQM2
names: Similarity
messages: Belongs to the BRINP family.

9541:BABAM1
gene id: 9541:BABAM1
uniprot id: I7G8X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9541:FAM133A
gene id: 9541:FAM133A
uniprot id: A0A2K5UK81
names: Similarity
messages: Belongs to the FAM133 family.

9541:HEBP1
gene id: 9541:HEBP1
uniprot id: A0A8J8YGT6
uniprot id: G7PJW7
names: Similarity
messages: Belongs to the HEBP family.

9541:BOLA2B
gene id: 9541:BOLA2B
uniprot id: A0A2K5WT49
names: Similarity
messages: Belongs to the BolA/IbaG family.

9541:HSDL2
gene id: 9541:HSDL2
uniprot id: G7PRN7
names: Subcellular Location Annotation
messages: Peroxisome

9541:ARSH
gene id: 9541:ARSH
uniprot id: A0A8J8XL05
uniprot id: G7Q249
names: Similarity
messages: Belongs to the sulfatase family.

9541:ABCA1
gene id: 9541:ABCA1
uniprot id: A0A2K5TYW7
names: Subcellular Location Annotation
messages: Membrane

9541:PPIH
gene id: 9541:PPIH
uniprot id: A0A2K5WFR7
uniprot id: A0A2K5WFS1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9541:LOC102122620
gene id: 9541:LOC102122620
uniprot id: G8F5H6
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9541:PKN2
gene id: 9541:PKN2
uniprot id: A0A2K5UQ73
uniprot id: A0A8J8YH34
uniprot id: G7NTM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9541:AKR1D1
gene id: 9541:AKR1D1
uniprot id: A0A2K5VT14
uniprot id: G8F421
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9541:LOC102125224
gene id: 9541:LOC102125224
uniprot id: G7Q2M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:GRPR
gene id: 9541:GRPR
uniprot id: A0A2K5U3F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:DAP3
gene id: 9541:DAP3
uniprot id: A0A2K5UUE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

9541:TBX19
gene id: 9541:TBX19
uniprot id: A0A2K5WKI5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:SLC25A40
gene id: 9541:SLC25A40
uniprot id: A0A2K5WGN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9541:TMEM98
gene id: 9541:TMEM98
uniprot id: A0A8J8Y645
uniprot id: G7PU17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9541:ELAVL2
gene id: 9541:ELAVL2
uniprot id: A0A2K5WY08
uniprot id: A0A2K5WY84
names: Similarity
messages: Belongs to the RRM elav family.

9541:LMX1A
gene id: 9541:LMX1A
uniprot id: A0A8J8YD50
uniprot id: G7NU26
names: Subcellular Location Annotation
messages: Nucleus

9541:CHD6
gene id: 9541:CHD6
uniprot id: A0A2K5V6Y8
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9541:MRFAP1L1
gene id: 9541:MRFAP1L1
uniprot id: A0A2K5UET2
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9541:DCN
gene id: 9541:DCN
uniprot id: A0A8J8Y354
uniprot id: Q4R5D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

9541:KRT38
gene id: 9541:KRT38
uniprot id: A0A2K5WNE6
names: Similarity
messages: Belongs to the intermediate filament family.

9541:NFIX
gene id: 9541:NFIX
uniprot id: A0A2K5WQ42
uniprot id: I7GMK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9541:PIGO
gene id: 9541:PIGO
uniprot id: A0A2K5W6E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:NR4A2
gene id: 9541:NR4A2
uniprot id: A0A2K5WEP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9541:NAA11
gene id: 9541:NAA11
uniprot id: G7P533
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9541:SRD5A3
gene id: 9541:SRD5A3
uniprot id: A0A2K5WDR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9541:INHBE
gene id: 9541:INHBE
uniprot id: A0A8J8YNK9
uniprot id: G7PIV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9541:NAP1L1
gene id: 9541:NAP1L1
uniprot id: A0A2K5TUU8
uniprot id: A0A2K5TUV1
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9541:MFF
gene id: 9541:MFF
uniprot id: A0A2K5X6A5
uniprot id: A0A2K5X6D5
uniprot id: A0A2K5X6D8
uniprot id: A0A2K5X6U7
uniprot id: A0A7N9I9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
messages: synaptic vesicle

9541:PTPRK
gene id: 9541:PTPRK
uniprot id: A0A2K5WV32
uniprot id: A0A7N9CLR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9541:BAG6
gene id: 9541:BAG6
uniprot id: G7P4P8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: cytosol
messages: extracellular exosome

9541:LOC102121923
gene id: 9541:LOC102121923
uniprot id: A0A7N9D2F1
names: Similarity
messages: Belongs to the MS4A family.

9541:MYF6
gene id: 9541:MYF6
uniprot id: A0A8J8YFV7
uniprot id: G7PIK1
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102145093
gene id: 9541:LOC102145093
uniprot id: Q4R9D1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
messages: Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2.

9541:ERGIC3
gene id: 9541:ERGIC3
uniprot id: A0A2K5WJC9
uniprot id: A0A2K5WJF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9541:TNFSF15
gene id: 9541:TNFSF15
uniprot id: A0A2K5UA22
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9541:PNPLA4
gene id: 9541:PNPLA4
uniprot id: A0A7N9D1X4
uniprot id: A0A8J8XB00
uniprot id: G7Q263
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:MRPL24
gene id: 9541:MRPL24
uniprot id: A0A2K5WEQ1
uniprot id: G8F6F0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9541:EIF3G
gene id: 9541:EIF3G
uniprot id: A0A2K5WAN0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9541:SF3A1
gene id: 9541:SF3A1
uniprot id: A0A2K5UZ38
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102122063
gene id: 9541:LOC102122063
uniprot id: A0A2K5X7S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9541:LOC102115347
gene id: 9541:LOC102115347
uniprot id: A0A2K5VRZ2
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

9541:TSACC
gene id: 9541:TSACC
uniprot id: Q4R7E8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TSACC family.
messages: Co-chaperone that facilitates HSP-mediated activation of TSSK6.
messages: Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and recruits TSACC to HSP90 (By similarity).

9541:MFN2
gene id: 9541:MFN2
uniprot id: A0A2K5VRH2
uniprot id: A0A8J8YMS9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9541:AHCYL1
gene id: 9541:AHCYL1
uniprot id: A0A2K5VMN0
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9541:LOC101864872
gene id: 9541:LOC101864872
uniprot id: A0A2K5UNF2
names: Similarity
messages: Belongs to the AAA ATPase family.

9541:TGIF2
gene id: 9541:TGIF2
uniprot id: A0A2K5U881
names: Subcellular Location Annotation
messages: Nucleus

9541:NAB1
gene id: 9541:NAB1
uniprot id: A0A2K5U7H0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9541:SERINC2
gene id: 9541:SERINC2
uniprot id: A0A2K5VYY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9541:CTBP2
gene id: 9541:CTBP2
uniprot id: A0A2K5WQL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9541:KPNA1
gene id: 9541:KPNA1
uniprot id: A0A8J8XYJ5
uniprot id: G7NXS0
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9541:IL1RAPL1
gene id: 9541:IL1RAPL1
uniprot id: A0A2K5WTU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

9541:ATP6V1G1
gene id: 9541:ATP6V1G1
uniprot id: A0A2K5TSA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:MTX3
gene id: 9541:MTX3
uniprot id: A0A2K5WAE1
uniprot id: A0A8J8Y6Z0
uniprot id: G7P7U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9541:TRMT2A
gene id: 9541:TRMT2A
uniprot id: A0A2K5WNL5
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LAMP5
gene id: 9541:LAMP5
uniprot id: A0A8J8XGG8
uniprot id: G7PGY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Membrane

9541:TEKT2
gene id: 9541:TEKT2
uniprot id: A0A2K5WAH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9541:HOXB8
gene id: 9541:HOXB8
uniprot id: A0A2K5V8D3
names: Subcellular Location Annotation
messages: Nucleus

9541:NCK1
gene id: 9541:NCK1
uniprot id: A0A2K5VQ82
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9541:ABCG5
gene id: 9541:ABCG5
uniprot id: A0A2K5WA04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9541:YPEL3
gene id: 9541:YPEL3
uniprot id: A0A2K5W800
names: Similarity
messages: Belongs to the yippee family.

9541:PDE4B
gene id: 9541:PDE4B
uniprot id: A0A2K5U5Z5
uniprot id: A0A8J8YHZ4
uniprot id: G7NW27
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:ACP1
gene id: 9541:ACP1
uniprot id: A0A2K5UKD7
uniprot id: A0A7N9IEE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9541:KDSR
gene id: 9541:KDSR
uniprot id: A0A7N9IDX9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:MOS
gene id: 9541:MOS
uniprot id: A0A2K5UF73
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:C4H6orf120
gene id: 9541:C4H6orf120
uniprot id: Q9BGQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
messages: Secreted

9541:CETN1
gene id: 9541:CETN1
uniprot id: A0A2K5UDL5
names: Similarity
messages: Belongs to the centrin family.

9541:SLC28A3
gene id: 9541:SLC28A3
uniprot id: A0A2K5WBF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9541:CHCHD4
gene id: 9541:CHCHD4
uniprot id: A0A8J8XW51
uniprot id: G7PIL3
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9541:HMGA2
gene id: 9541:HMGA2
uniprot id: A0A2K5VEY0
uniprot id: A0A2K5VF57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9541:CKAP5
gene id: 9541:CKAP5
uniprot id: A0A2K5TX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

9541:CCNG2
gene id: 9541:CCNG2
uniprot id: A0A2K5W7D5
names: Similarity
messages: Belongs to the cyclin family.

9541:SLITRK2
gene id: 9541:SLITRK2
uniprot id: A0A8J8YCU9
uniprot id: G7Q1V4
names: Similarity
messages: Belongs to the SLITRK family.

9541:GLYR1
gene id: 9541:GLYR1
uniprot id: A0A2K5V2L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

9541:SPAM1
gene id: 9541:SPAM1
uniprot id: A0A2K5U3E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9541:CRYGN
gene id: 9541:CRYGN
uniprot id: A0A2K5VIL8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:ASB10
gene id: 9541:ASB10
uniprot id: A0A2K5ULT4
uniprot id: A0A2K5ULT9
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:PPP4C
gene id: 9541:PPP4C
uniprot id: A0A2K5U642
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9541:CHST9
gene id: 9541:CHST9
uniprot id: A0A8J8YFQ8
uniprot id: G7PWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:NRP1
gene id: 9541:NRP1
uniprot id: A0A2K5V5B8
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ABI1
gene id: 9541:ABI1
uniprot id: A0A2K5UYX9
uniprot id: A0A2K5UYY2
uniprot id: A0A2K5UZ16
uniprot id: A0A2K5UZ21
uniprot id: A0A2K5UZ55
uniprot id: Q2PFU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9541:HSPB3
gene id: 9541:HSPB3
uniprot id: A0A2K5UR85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9541:H1-4
gene id: 9541:H1-4
uniprot id: A0A8J8Y8N7
uniprot id: G7P2M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9541:SUFU
gene id: 9541:SUFU
uniprot id: G7PDV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9541:PHOSPHO1
gene id: 9541:PHOSPHO1
uniprot id: A0A2K5V191
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9541:ANAPC10
gene id: 9541:ANAPC10
uniprot id: A0A2K5U8L7
uniprot id: A0A7N9IH85
uniprot id: I7GEV9
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9541:CNR1
gene id: 9541:CNR1
uniprot id: G7P3K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.
messages: Interacts (via C-terminus) with CNRIP1.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

9541:TMEM14A
gene id: 9541:TMEM14A
uniprot id: A0A2K5UQD5
names: Similarity
messages: Belongs to the TMEM14 family.

9541:CA7
gene id: 9541:CA7
uniprot id: A0A2K5U255
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9541:LOC102138082
gene id: 9541:LOC102138082
uniprot id: A0A2K5TLD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

9541:TSPAN12
gene id: 9541:TSPAN12
uniprot id: A0A8J8XYI1
uniprot id: G7P0I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:GALNT3
gene id: 9541:GALNT3
uniprot id: A0A2K5VSB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:BRPF1
gene id: 9541:BRPF1
uniprot id: A0A2K5VVC2
uniprot id: A0A8J8XYP3
uniprot id: G7NYU9
names: Subcellular Location Annotation
messages: Nucleus

9541:FIS1
gene id: 9541:FIS1
uniprot id: A0A8J8XPZ8
uniprot id: G7P145
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

9541:USE1
gene id: 9541:USE1
uniprot id: A0A2K5X308
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LOC102144965
gene id: 9541:LOC102144965
uniprot id: A0A2K5ULV2
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:CASP2
gene id: 9541:CASP2
uniprot id: A0A2K5VYW8
names: Similarity
messages: Belongs to the peptidase C14A family.

9541:SPDYA
gene id: 9541:SPDYA
uniprot id: A0A8J8YGP1
uniprot id: G7PLY1
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9541:KCNJ2
gene id: 9541:KCNJ2
uniprot id: A0A2K5UEJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

9541:DCTN2
gene id: 9541:DCTN2
uniprot id: I7GHC5
names: Similarity
messages: Belongs to the dynactin subunit 2 family.

9541:PLD5
gene id: 9541:PLD5
uniprot id: A0A2K5WPG7
names: Similarity
messages: Belongs to the phospholipase D family.

9541:TMEM245
gene id: 9541:TMEM245
uniprot id: A0A2K5UKF6
uniprot id: A0A7N9IC78
uniprot id: A0A7N9ICT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

9541:NFYA
gene id: 9541:NFYA
uniprot id: A0A2K5WQS6
uniprot id: A0A7N9DA59
uniprot id: A0A8J8XVK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9541:PSMG2
gene id: 9541:PSMG2
uniprot id: A0A8J8Y8Q2
uniprot id: G7PWB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9541:TAS2R41
gene id: 9541:TAS2R41
uniprot id: G7P1I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:ATF1
gene id: 9541:ATF1
uniprot id: A0A8J8XPW8
uniprot id: G7PIA6
names: Subcellular Location Annotation
messages: Nucleus

9541:UTP11
gene id: 9541:UTP11
uniprot id: A0A8J8YJG7
uniprot id: G7NUB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9541:DUSP29
gene id: 9541:DUSP29
uniprot id: A0A2K5TMM7
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9541:SDR9C7
gene id: 9541:SDR9C7
uniprot id: A0A2K5WES2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:LACTB2
gene id: 9541:LACTB2
uniprot id: A0A8J8XH33
uniprot id: G7PC06
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9541:ELOVL7
gene id: 9541:ELOVL7
uniprot id: A0A2K5WJH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9541:FGFR1OP2
gene id: 9541:FGFR1OP2
uniprot id: A0A2K5VDJ4
names: Similarity
messages: Belongs to the SIKE family.

9541:CAPN11
gene id: 9541:CAPN11
uniprot id: A0A2K5X3S1
names: Similarity
messages: Belongs to the peptidase C2 family.

9541:APOBEC3G
gene id: 9541:APOBEC3G
uniprot id: Q05JX4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm
messages: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.
messages: Homodimer.
messages: Nucleus
messages: P-body
messages: The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.

9541:RAD23A
gene id: 9541:RAD23A
uniprot id: A0A2K5W9S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9541:CAPZA1
gene id: 9541:CAPZA1
uniprot id: A0A2K5UBE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9541:PARP8
gene id: 9541:PARP8
uniprot id: A0A2K5W8E2
uniprot id: A0A2K5W8K0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9541:ELOVL3
gene id: 9541:ELOVL3
uniprot id: A0A8J8Y4P6
uniprot id: G7PDU3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9541:CRIPT
gene id: 9541:CRIPT
uniprot id: A0A2K5U226
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

9541:POLR2I
gene id: 9541:POLR2I
uniprot id: A0A8J8XYY8
uniprot id: G7PXC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9541:NDUFC1
gene id: 9541:NDUFC1
uniprot id: A0A2K5WCF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:GTF2F2
gene id: 9541:GTF2F2
uniprot id: A0A2K5UGW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9541:TAF1
gene id: 9541:TAF1
uniprot id: A0A2K5TVS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

9541:MAGT1
gene id: 9541:MAGT1
uniprot id: A0A2K5UWR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:ORC2
gene id: 9541:ORC2
uniprot id: A0A8J8XQH4
uniprot id: Q4R797
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9541:SETD6
gene id: 9541:SETD6
uniprot id: A0A7N9D0A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

9541:GAST
gene id: 9541:GAST
uniprot id: A0A2K5V138
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9541:B3GAT2
gene id: 9541:B3GAT2
uniprot id: A0A2K5WUT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:ATP5F1A
gene id: 9541:ATP5F1A
uniprot id: A0A2K5TVD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9541:LIM2
gene id: 9541:LIM2
uniprot id: A0A8J8Y6W6
uniprot id: G7PYH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

9541:PPP1R2
gene id: 9541:PPP1R2
uniprot id: A0A8J8XWF8
uniprot id: G7NYS0
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9541:TEF
gene id: 9541:TEF
uniprot id: A0A2K5V8M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9541:EDNRA
gene id: 9541:EDNRA
uniprot id: A0A2K5TPJ0
uniprot id: A0A8J8YQK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9541:PPP2R3C
gene id: 9541:PPP2R3C
uniprot id: A0A8J8YFJ9
uniprot id: G7PA30
names: Subcellular Location Annotation
messages: Nucleus

9541:BPNT1
gene id: 9541:BPNT1
uniprot id: A0A2K5WD40
uniprot id: A0A2K5WD73
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9541:MYMK
gene id: 9541:MYMK
uniprot id: A0A2K5TN97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9541:POLR2E
gene id: 9541:POLR2E
uniprot id: A0A8J8Y181
uniprot id: G7PYA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

9541:RPRD1A
gene id: 9541:RPRD1A
uniprot id: A0A2K5TPT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

9541:CRHR2
gene id: 9541:CRHR2
uniprot id: A0A2K5WRX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

9541:GDE1
gene id: 9541:GDE1
uniprot id: A0A2K5UZ26
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9541:GCSH
gene id: 9541:GCSH
uniprot id: A0A8J8YM65
uniprot id: G7PZT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9541:LOC102122055
gene id: 9541:LOC102122055
uniprot id: A0A2K5WUZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9541:NSG2
gene id: 9541:NSG2
uniprot id: Q4R4W7
names: Similarity
messages: Belongs to the NSG family.

9541:PC
gene id: 9541:PC
uniprot id: A0A2K5VMP7
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

9541:PTK7
gene id: 9541:PTK7
uniprot id: A0A2K5VNQ6
names: Subcellular Location Annotation
messages: Membrane

9541:SMIM19
gene id: 9541:SMIM19
uniprot id: A0A8J8XIJ5
uniprot id: G7PBS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9541:ERLIN2
gene id: 9541:ERLIN2
uniprot id: A0A2K5URK3
uniprot id: A0A7N9CRK4
uniprot id: A0A8J8YHC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9541:C3H7orf25
gene id: 9541:C3H7orf25
uniprot id: A0A2K5UKP3
uniprot id: A0A7N9D8R8
names: Similarity
messages: Belongs to the UPF0415 family.

9541:RFX2
gene id: 9541:RFX2
uniprot id: A0A2K5U4G0
uniprot id: A0A2K5U4L9
names: Subcellular Location Annotation
messages: Nucleus

9541:MRPS26
gene id: 9541:MRPS26
uniprot id: A0A2K5UMK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9541:PSIP1
gene id: 9541:PSIP1
uniprot id: A0A8J8YF26
uniprot id: G7PSB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9541:ERGIC1
gene id: 9541:ERGIC1
uniprot id: A0A2K5WJ70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9541:FDPS
gene id: 9541:FDPS
uniprot id: I7GHV0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9541:PDP2
gene id: 9541:PDP2
uniprot id: A0A8J8YJS8
uniprot id: G7Q1C0
names: Similarity
messages: Belongs to the PP2C family.

9541:STK17B
gene id: 9541:STK17B
uniprot id: A0A2K5UTS2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:VANGL1
gene id: 9541:VANGL1
uniprot id: A0A2K5UAJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9541:RPP30
gene id: 9541:RPP30
uniprot id: A0A2K5UTP1
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9541:PCSK2
gene id: 9541:PCSK2
uniprot id: A0A8J8YR00
uniprot id: G7PH08
names: Similarity
messages: Belongs to the peptidase S8 family.

9541:POLR2J
gene id: 9541:POLR2J
uniprot id: A0A2K5X258
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9541:ORMDL2
gene id: 9541:ORMDL2
uniprot id: A0A2K5VGZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9541:DENR
gene id: 9541:DENR
uniprot id: A0A2K5TSX6
names: Similarity
messages: Belongs to the DENR family.

9541:HOXB6
gene id: 9541:HOXB6
uniprot id: A0A2K5TYT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9541:SRP9
gene id: 9541:SRP9
uniprot id: G8F5S9
uniprot id: Q4R6I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP14; binds RNA as heterodimer (By similarity). Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity).

9541:GADL1
gene id: 9541:GADL1
uniprot id: A0A8J8XCW0
uniprot id: G7NYB1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9541:VAC14
gene id: 9541:VAC14
uniprot id: A0A2K5WZL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

9541:RNF141
gene id: 9541:RNF141
uniprot id: A0A2K5VWB7
names: Function
messages: May be involved in spermatogenesis.

9541:LOC102144634
gene id: 9541:LOC102144634
uniprot id: A0A2K5UHJ7
names: Subcellular Location Annotation
messages: Secreted

9541:QPCTL
gene id: 9541:QPCTL
uniprot id: G8F4B6
uniprot id: Q4R942
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutaminyl-peptide cyclotransferase family.
messages: Golgi apparatus membrane
messages: It is unclear whether this protein requires a metal cofactor for catalysis. It was originally proposed to be a Zn(2+)-dependent metalloenzyme based on structural similarities to bacterial aminopeptidases and the observation that it can bind Zn(2+) ions, typically in a 1:1 stoichiometry (By similarity). However, a recent study suggests a Zn(2+)-independent catalytic mechanism (By similarity).
messages: Responsible for the biosynthesis of pyroglutamyl peptides.

9541:PUF60
gene id: 9541:PUF60
uniprot id: A0A2K5VFX0
uniprot id: A0A2K5VG32
uniprot id: A0A2K5VG43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

9541:INTS14
gene id: 9541:INTS14
uniprot id: A0A2K5UXS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9541:CDK14
gene id: 9541:CDK14
uniprot id: A0A2K5VRA3
uniprot id: A0A7N9DC80
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:PFDN4
gene id: 9541:PFDN4
uniprot id: A0A8J8XPQ5
uniprot id: G7PFU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9541:SFXN2
gene id: 9541:SFXN2
uniprot id: A0A2K5VRW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9541:COLGALT2
gene id: 9541:COLGALT2
uniprot id: A0A7N9CJM5
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9541:DNAL4
gene id: 9541:DNAL4
uniprot id: A0A2K5V5L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9541:SLC17A3
gene id: 9541:SLC17A3
uniprot id: A0A8J8XYE1
uniprot id: G7P2K7
names: Subcellular Location Annotation
messages: Membrane

9541:TFE3
gene id: 9541:TFE3
uniprot id: A0A8J8YBY1
uniprot id: G7Q2P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9541:SNX1
gene id: 9541:SNX1
uniprot id: A0A7N9IGR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9541:RIPPLY2
gene id: 9541:RIPPLY2
uniprot id: A0A2K5WUW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9541:CMTM3
gene id: 9541:CMTM3
uniprot id: A0A2K5X5K3
names: Subcellular Location Annotation
messages: Membrane

9541:SLC25A51
gene id: 9541:SLC25A51
uniprot id: A0A7N9CMS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:PSD3
gene id: 9541:PSD3
uniprot id: A0A2K5TVK8
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9541:MRPL28
gene id: 9541:MRPL28
uniprot id: A0A2K5UD28
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

9541:PRPF38B
gene id: 9541:PRPF38B
uniprot id: A0A2K5UDD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9541:GNG2
gene id: 9541:GNG2
uniprot id: G7PA91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:PRKAB1
gene id: 9541:PRKAB1
uniprot id: A0A8J8XCL8
uniprot id: G7PIT4
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9541:STEAP3
gene id: 9541:STEAP3
uniprot id: A0A2K5W645
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9541:ALDOB
gene id: 9541:ALDOB
uniprot id: A0A8J8Y5A0
uniprot id: G7PRT5
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9541:FOXO4
gene id: 9541:FOXO4
uniprot id: A0A8J8YHY7
uniprot id: G7Q2Z4
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102119787
gene id: 9541:LOC102119787
uniprot id: G7PCH4
uniprot id: Q4R5B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
messages: Mitochondrion inner membrane

9541:DPCD
gene id: 9541:DPCD
uniprot id: A0A2K5TMH4
names: Similarity
messages: Belongs to the DPCD family.

9541:PACSIN1
gene id: 9541:PACSIN1
uniprot id: A0A2K5U5M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9541:HORMAD1
gene id: 9541:HORMAD1
uniprot id: Q4R8B9
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Interacts with HORMAD2. Interacts with IHO1.
messages: Nucleus
messages: Phosphorylated at Ser-377 in a SPO11-dependent manner.
messages: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.

9541:SSR2
gene id: 9541:SSR2
uniprot id: G7NV73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9541:FAM149B1
gene id: 9541:FAM149B1
uniprot id: A0A2K5WD96
names: Similarity
messages: Belongs to the FAM149 family.

9541:SOX30
gene id: 9541:SOX30
uniprot id: Q8WNV5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as both a transcriptional activator and repressor (By similarity). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (By similarity). Binds to its own promoter and activates its own transcription (By similarity). Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (By similarity). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity).
messages: Cytoplasm
messages: Interacts with CTNNB1, competitively inhibiting CTNNB1-TCF7L2/TCF4 interaction.
messages: Nucleus

9541:SLITRK3
gene id: 9541:SLITRK3
uniprot id: A0A8J8XAS2
uniprot id: G7NZH4
names: Similarity
messages: Belongs to the SLITRK family.

9541:OGT
gene id: 9541:OGT
uniprot id: A0A2K5TWY1
uniprot id: A0A8J8XT42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9541:TFDP3
gene id: 9541:TFDP3
uniprot id: A0A2K5US80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9541:SULF1
gene id: 9541:SULF1
uniprot id: A0A2K5VH45
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9541:GTPBP10
gene id: 9541:GTPBP10
uniprot id: A0A2K5UHT5
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9541:C5AR1
gene id: 9541:C5AR1
uniprot id: A0A7N9IEK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9541:UBL3
gene id: 9541:UBL3
uniprot id: A0A8J8XZA0
uniprot id: G7PVY1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:FGF17
gene id: 9541:FGF17
uniprot id: A0A2K5V360
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:HARS2
gene id: 9541:HARS2
uniprot id: A0A2K5W7T9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9541:TYR
gene id: 9541:TYR
uniprot id: A0A2K5VT29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9541:S100A9
gene id: 9541:S100A9
uniprot id: A0A2K5VRV3
names: Similarity
messages: Belongs to the S-100 family.

9541:YTHDC1
gene id: 9541:YTHDC1
uniprot id: A0A2K5UZ42
uniprot id: A0A2K5UZA9
uniprot id: G7P5Q2
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9541:STAC3
gene id: 9541:STAC3
uniprot id: A0A2K5X2G2
names: Subcellular Location Annotation
messages: sarcolemma

9541:CPA6
gene id: 9541:CPA6
uniprot id: A0A2K5WY88
names: Similarity
messages: Belongs to the peptidase M14 family.

9541:LOC102120647
gene id: 9541:LOC102120647
uniprot id: A0A2K5X0X6
names: Similarity
messages: Belongs to the DNAJC25 family.

9541:IREB2
gene id: 9541:IREB2
uniprot id: A0A2K5X545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

9541:LOC102140281
gene id: 9541:LOC102140281
uniprot id: A0A2K5UVK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9541:LPAR1
gene id: 9541:LPAR1
uniprot id: I7GN66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9541:FOXJ2
gene id: 9541:FOXJ2
uniprot id: A0A2K5VAZ9
names: Subcellular Location Annotation
messages: Nucleus

9541:RPL13A
gene id: 9541:RPL13A
uniprot id: I7GKG8
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9541:GRIK1
gene id: 9541:GRIK1
uniprot id: A0A2K5X2V7
uniprot id: A0A2K5X344
uniprot id: A0A2K5X351
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:LYN
gene id: 9541:LYN
uniprot id: A0A2K5VF55
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:ODR4
gene id: 9541:ODR4
uniprot id: A0A2K5V8C2
uniprot id: A0A2K5V8C9
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9541:ECRG4
gene id: 9541:ECRG4
uniprot id: A0A2K5W2S1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9541:SERPINE1
gene id: 9541:SERPINE1
uniprot id: A0A8J8Y4W5
uniprot id: G7P138
names: Similarity
messages: Belongs to the serpin family.

9541:IDI1
gene id: 9541:IDI1
uniprot id: A0A2K5UKE6
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9541:PICK1
gene id: 9541:PICK1
uniprot id: A0A2K5WCA7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9541:GNB3
gene id: 9541:GNB3
uniprot id: A0A8J8XKZ3
uniprot id: G7PJN5
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9541:LOC101926677
gene id: 9541:LOC101926677
uniprot id: A0A7N9DCN7
names: Subcellular Location Annotation
messages: Nucleus

9541:NECTIN3
gene id: 9541:NECTIN3
uniprot id: A0A7N9CGE7
names: Similarity
messages: Belongs to the nectin family.

9541:FAM32A
gene id: 9541:FAM32A
uniprot id: A0A8J8XI49
uniprot id: G7PZQ2
names: Similarity
messages: Belongs to the FAM32 family.

9541:PTGES
gene id: 9541:PTGES
uniprot id: G7PRD3
uniprot id: Q6PWL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAPEG family.
messages: Homotrimer.
messages: Membrane
messages: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).
messages: perinuclear region

9541:GRIN2B
gene id: 9541:GRIN2B
uniprot id: A0A8J8YJG1
uniprot id: G7PJX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:PSMD9
gene id: 9541:PSMD9
uniprot id: A0A8J8XFE0
uniprot id: G7PJ73
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9541:HK3
gene id: 9541:HK3
uniprot id: A0A2K5U647
names: Similarity
messages: Belongs to the hexokinase family.

9541:LOC102129291
gene id: 9541:LOC102129291
uniprot id: A0A8J8Y8V5
uniprot id: A7XEI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9541:WASL
gene id: 9541:WASL
uniprot id: A0A2K5VG25
names: Subcellular Location Annotation
messages: Nucleus

9541:AQP5
gene id: 9541:AQP5
uniprot id: A0A2K5V4J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9541:DESI2
gene id: 9541:DESI2
uniprot id: A0A2K5V2W7
names: Similarity
messages: Belongs to the DeSI family.

9541:RIC8B
gene id: 9541:RIC8B
uniprot id: A0A2K5WDJ4
uniprot id: A0A2K5WDN6
uniprot id: A0A2K5WDW8
uniprot id: A0A7N9CPF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9541:VCAM1
gene id: 9541:VCAM1
uniprot id: A0A2K5UM33
names: Subcellular Location Annotation
messages: Cell membrane

9541:PACC1
gene id: 9541:PACC1
uniprot id: A0A8J8Y0N5
uniprot id: G7NUL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9541:GNPNAT1
gene id: 9541:GNPNAT1
uniprot id: A0A7N9CA22
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9541:PDRG1
gene id: 9541:PDRG1
uniprot id: A0A2K5TWM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9541:BLVRA
gene id: 9541:BLVRA
uniprot id: A0A2K5X5P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

9541:MAT1A
gene id: 9541:MAT1A
uniprot id: A0A2K5WMF0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9541:SMAD3
gene id: 9541:SMAD3
uniprot id: A0A2K5TVQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9541:POSTN
gene id: 9541:POSTN
uniprot id: A0A2K5VW02
uniprot id: A0A2K5VW23
uniprot id: A0A2K5VW96
uniprot id: A0A2K5VWG9
uniprot id: G7PW19
names: Subcellular Location Annotation
messages: extracellular matrix

9541:LANCL1
gene id: 9541:LANCL1
uniprot id: A0A2K5VVY4
uniprot id: A0A2K5VWA1
uniprot id: A0A979HLA0
names: Similarity
messages: Belongs to the LanC-like protein family.

9541:BGN
gene id: 9541:BGN
uniprot id: A0A8J8YQ10
uniprot id: G7Q1Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

9541:ZNF449
gene id: 9541:ZNF449
uniprot id: A0A2K5WPM8
uniprot id: A0A8J8XYN0
names: Subcellular Location Annotation
messages: Nucleus

9541:BARX2
gene id: 9541:BARX2
uniprot id: A0A2K5WJU7
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102117998
gene id: 9541:LOC102117998
uniprot id: A0A2K5UJT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CCN4
gene id: 9541:CCN4
uniprot id: A0A8J8XJS4
uniprot id: G7PD02
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:MPC2
gene id: 9541:MPC2
uniprot id: A0A2K5WT03
uniprot id: G8F4T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9541:DCST2
gene id: 9541:DCST2
uniprot id: A0A2K5VG69
names: Subcellular Location Annotation
messages: Membrane

9541:THG1L
gene id: 9541:THG1L
uniprot id: A0A2K5VWY9
uniprot id: A0A8J8XA90
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

9541:LOC102131133
gene id: 9541:LOC102131133
uniprot id: A0A2K5WE79
uniprot id: G7P6C8
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TNFRSF14
gene id: 9541:TNFRSF14
uniprot id: A0A2K5W0R1
uniprot id: A0A7N9CGR4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:EGFL7
gene id: 9541:EGFL7
uniprot id: A0A2K5VD40
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CENPH
gene id: 9541:CENPH
uniprot id: A0A2K5W8L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9541:GPR52
gene id: 9541:GPR52
uniprot id: G8F2R8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:STX3
gene id: 9541:STX3
uniprot id: A0A7N9C9E6
names: Similarity
messages: Belongs to the syntaxin family.

9541:CA8
gene id: 9541:CA8
uniprot id: A0A2K5V8M9
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9541:DLD
gene id: 9541:DLD
uniprot id: A0A2K5TZW4
uniprot id: Q60HG3
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer. Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDHA (PDHA1 or PDHA2) and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (by non covalent bonds). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with PDHX.
messages: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: The active site is a redox-active disulfide bond.
messages: Tyrosine phosphorylated.
messages: acrosome
messages: flagellum

9541:LOC101925125
gene id: 9541:LOC101925125
uniprot id: A0A2K5VY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

9541:WNT7A
gene id: 9541:WNT7A
uniprot id: G7NYG1
uniprot id: Q1KYK9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Wnt family.
messages: Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD5. Interacts with PORCN (By similarity). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (By similarity).
messages: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity).
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells.
messages: extracellular matrix

9541:TMEM39A
gene id: 9541:TMEM39A
uniprot id: A0A2K5WRG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9541:LOC101866572
gene id: 9541:LOC101866572
uniprot id: A0A2K5VUS6
uniprot id: G8F5P9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

9541:PSMC5
gene id: 9541:PSMC5
uniprot id: I7G7U1
names: Similarity
messages: Belongs to the AAA ATPase family.

9541:TSPAN6
gene id: 9541:TSPAN6
uniprot id: A0A8J8Y336
uniprot id: G7Q377
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:PIK3R3
gene id: 9541:PIK3R3
uniprot id: A0A2K5TJZ8
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9541:MYADM
gene id: 9541:MYADM
uniprot id: A0A2K5UNG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9541:CLCN4
gene id: 9541:CLCN4
uniprot id: A0A8J8YMS8
uniprot id: G7Q273
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9541:CEBPE
gene id: 9541:CEBPE
uniprot id: A0A7N9D2L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9541:TMEM229B
gene id: 9541:TMEM229B
uniprot id: A0A2K5UEI4
uniprot id: A0A7N9D440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9541:IFITM1
gene id: 9541:IFITM1
uniprot id: A0A2K5U3Q2
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:YIPF5
gene id: 9541:YIPF5
uniprot id: Q4R5M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YIP1 family.
messages: COPII-coated vesicle
messages: Endoplasmic reticulum membrane
messages: Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B) (By similarity). Interacts with YIF1A (By similarity). May interact with RAB1A (By similarity). Interacts with YIPF3 and YIPF4 (By similarity).
messages: Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi.
messages: cis-Golgi network membrane

9541:IGBP1
gene id: 9541:IGBP1
uniprot id: A0A2K5WIE3
names: Similarity
messages: Belongs to the IGBP1/TAP42 family.

9541:BCOR
gene id: 9541:BCOR
uniprot id: A0A2K5W0P1
names: Similarity
messages: Belongs to the BCOR family.

9541:ESR2
gene id: 9541:ESR2
uniprot id: A0A2K5W2L5
uniprot id: A0A8J8Y5F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9541:AGPAT1
gene id: 9541:AGPAT1
uniprot id: A0A8J8YED8
uniprot id: G7P2Q6
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9541:TNFSF4
gene id: 9541:TNFSF4
uniprot id: A0A2K5TTN0
uniprot id: A0A7N9CLL2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9541:RIOX2
gene id: 9541:RIOX2
uniprot id: A0A2K5VVK1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. MINA53 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.

9541:SLC20A2
gene id: 9541:SLC20A2
uniprot id: A0A2K5UAN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

9541:DPEP1
gene id: 9541:DPEP1
uniprot id: A0A8J8YK92
uniprot id: G7PZZ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9541:LRRC8A
gene id: 9541:LRRC8A
uniprot id: A0A2K5VRD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9541:NXPE3
gene id: 9541:NXPE3
uniprot id: A0A8J8XZK5
uniprot id: G7NZQ2
names: Similarity
messages: Belongs to the NXPE family.

9541:NPY
gene id: 9541:NPY
uniprot id: A0A2K5VHQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9541:ANKRD13B
gene id: 9541:ANKRD13B
uniprot id: A0A2K5TXT8
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9541:LOC102129218
gene id: 9541:LOC102129218
uniprot id: A0A8J8YQC6
uniprot id: G7P6I7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:UPF2
gene id: 9541:UPF2
uniprot id: A0A2K5VJ20
names: Subcellular Location Annotation
messages: Cytoplasm

9541:EPHB4
gene id: 9541:EPHB4
uniprot id: A0A2K5V953
names: Subcellular Location Annotation
messages: Membrane

9541:BTG2
gene id: 9541:BTG2
uniprot id: A0A2K5UJW1
names: Similarity
messages: Belongs to the BTG family.

9541:SERPINB2
gene id: 9541:SERPINB2
uniprot id: A0A2K5VAJ6
names: Similarity
messages: Belongs to the serpin family.

9541:GHRL
gene id: 9541:GHRL
uniprot id: A0A2K5VHC7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
messages: O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
messages: Secreted

9541:LOC102121958
gene id: 9541:LOC102121958
uniprot id: A0A7N9CAV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:FAM163A
gene id: 9541:FAM163A
uniprot id: A0A8J8YA09
uniprot id: G7NU05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9541:LMBR1
gene id: 9541:LMBR1
uniprot id: A0A2K5UYG8
names: Similarity
messages: Belongs to the LIMR family.

9541:AGPAT2
gene id: 9541:AGPAT2
uniprot id: A0A2K5WF11
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9541:IFNGR1
gene id: 9541:IFNGR1
uniprot id: G7P327
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9541:CERT1
gene id: 9541:CERT1
uniprot id: A0A8J8Y6D8
uniprot id: G7P7R6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

9541:CLDN16
gene id: 9541:CLDN16
uniprot id: A0A2K5VEM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:TMEM106B
gene id: 9541:TMEM106B
uniprot id: A0A2K5W4F7
names: Similarity
messages: Belongs to the TMEM106 family.

9541:SLITRK6
gene id: 9541:SLITRK6
uniprot id: A0A2K5TPB1
names: Similarity
messages: Belongs to the SLITRK family.

9541:CA11
gene id: 9541:CA11
uniprot id: A0A8J8XZV3
uniprot id: G7PY41
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9541:NDUFS2
gene id: 9541:NDUFS2
uniprot id: A0A7N9CR31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 49 kDa subunit family.
messages: Mitochondrion inner membrane

9541:SLC17A6
gene id: 9541:SLC17A6
uniprot id: A0A2K5WED2
uniprot id: G8F4T4
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102137997
gene id: 9541:LOC102137997
uniprot id: A0A2K5UN85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:MYC
gene id: 9541:MYC
uniprot id: G7PCT8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
messages: nucleolus
messages: nucleoplasm

9541:LHFPL1
gene id: 9541:LHFPL1
uniprot id: A0A2K5W8R0
names: Subcellular Location Annotation
messages: Membrane

9541:RGS4
gene id: 9541:RGS4
uniprot id: A0A2K5U7U7
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9541:SLC5A7
gene id: 9541:SLC5A7
uniprot id: A0A8J8YA03
uniprot id: G7PMW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9541:PTGR2
gene id: 9541:PTGR2
uniprot id: A0A2K5WQJ4
uniprot id: A0A7N9DCK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9541:LOC102141626
gene id: 9541:LOC102141626
uniprot id: A0A2K5UIP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:CA12
gene id: 9541:CA12
uniprot id: A0A2K5TSA5
uniprot id: A0A2K5TSB2
uniprot id: A0A7N9IEH5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9541:HDHD3
gene id: 9541:HDHD3
uniprot id: A0A8J8YNL2
uniprot id: G7PRM3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9541:TMEM135
gene id: 9541:TMEM135
uniprot id: A0A2K5UGY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane

9541:ACTN3
gene id: 9541:ACTN3
uniprot id: A0A2K5VIN2
names: Similarity
messages: Belongs to the alpha-actinin family.

9541:POLR3A
gene id: 9541:POLR3A
uniprot id: A0A8J8YMI0
uniprot id: G7PEY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9541:UNC5D
gene id: 9541:UNC5D
uniprot id: A0A2K5X484
uniprot id: A0A2K5X486
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9541:HNRNPH2
gene id: 9541:HNRNPH2
uniprot id: A0A2K5W0Q6
names: Subcellular Location Annotation
messages: nucleoplasm

9541:LOC101865922
gene id: 9541:LOC101865922
uniprot id: A0A2K5U0B2
uniprot id: I7GLL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9541:ELAVL4
gene id: 9541:ELAVL4
uniprot id: A0A2K5WYQ9
uniprot id: A0A2K5WYZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9541:CHN1
gene id: 9541:CHN1
uniprot id: A0A2K5TZQ2
names: Function
messages: GTPase-activating protein for p21-rac.

9541:ST3GAL1
gene id: 9541:ST3GAL1
uniprot id: A0A2K5VC45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:CPB1
gene id: 9541:CPB1
uniprot id: A0A2K5TX20
names: Similarity
messages: Belongs to the peptidase M14 family.

9541:DEFB119
gene id: 9541:DEFB119
uniprot id: A0A2K5VG20
uniprot id: A0A2K5VG64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:AQP9
gene id: 9541:AQP9
uniprot id: A0A8J8Y8Y4
uniprot id: G7PBK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9541:BRF2
gene id: 9541:BRF2
uniprot id: A0A8J8Y646
uniprot id: G7PD66
names: Subcellular Location Annotation
messages: Nucleus

9541:USO1
gene id: 9541:USO1
uniprot id: A0A2K5WJH1
uniprot id: A0A2K5WJK0
uniprot id: A0A7N9CYF0
uniprot id: G7P562
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

9541:MRPL27
gene id: 9541:MRPL27
uniprot id: A0A7N9CWB8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9541:FAM174A
gene id: 9541:FAM174A
uniprot id: A0A2K5V3R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9541:PEX5
gene id: 9541:PEX5
uniprot id: G7PJP8
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9541:PAFAH1B1
gene id: 9541:PAFAH1B1
uniprot id: Q8HXX0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity. Interacts with the catalytic dimer of PAF-AH (I) heterotetrameric enzyme: interacts with PAFAH1B2 homodimer (alpha2/alpha2 homodimer), PAFAH1B3 homodimer (alpha1/alpha1 homodimer) and PAFAH1B2-PAFAH1B3 heterodimer (alpha2/alpha1 heterodimer) (By similarity). Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Interacts with INTS13. Interacts with DCDC1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity).
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

9541:SLC45A3
gene id: 9541:SLC45A3
uniprot id: A0A2K5WQN9
uniprot id: Q95KI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
messages: Membrane
messages: Proton-associated sucrose transporter. May be able to transport also glucose and fructose.

9541:HOXB13
gene id: 9541:HOXB13
uniprot id: A0A2K5WY17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9541:FOXN4
gene id: 9541:FOXN4
uniprot id: A0A2K5UWB7
names: Subcellular Location Annotation
messages: Nucleus

9541:FUT9
gene id: 9541:FUT9
uniprot id: A0A8J8XZV7
uniprot id: G7P425
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9541:FOXR2
gene id: 9541:FOXR2
uniprot id: A0A7N9CQV5
uniprot id: G8F4L6
names: Subcellular Location Annotation
messages: Nucleus

9541:ATP5MG
gene id: 9541:ATP5MG
uniprot id: A0A7N9DCI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9541:LIMK2
gene id: 9541:LIMK2
uniprot id: A0A2K5W121
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9541:TLR2
gene id: 9541:TLR2
uniprot id: Q95M53
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
messages: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
messages: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).
messages: Membrane
messages: Membrane raft
messages: The ATG16L1-binding motif mediates interaction with ATG16L1.
messages: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
messages: phagosome membrane

9541:TFR2
gene id: 9541:TFR2
uniprot id: A0A2K5UB49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9541:PLPPR1
gene id: 9541:PLPPR1
uniprot id: A0A2K5TN07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9541:CYSTM1
gene id: 9541:CYSTM1
uniprot id: A0A7N9CIF1
uniprot id: A0A8J8XDV0
uniprot id: G7P8G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

9541:LSM14B
gene id: 9541:LSM14B
uniprot id: A0A2K5WW67
uniprot id: A0A2K5WWR6
names: Similarity
messages: Belongs to the LSM14 family.

9541:BDKRB1
gene id: 9541:BDKRB1
uniprot id: Q3BCU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
messages: Cell membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9541:B3GNT2
gene id: 9541:B3GNT2
uniprot id: A0A8J8YEF2
uniprot id: G7PMA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:LOC102124950
gene id: 9541:LOC102124950
uniprot id: A0A2K5UKD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9541:FLNB
gene id: 9541:FLNB
uniprot id: A0A2K5WH26
uniprot id: A0A2K5WHB3
names: Similarity
messages: Belongs to the filamin family.

9541:ZER1
gene id: 9541:ZER1
uniprot id: A0A8J8XPV2
uniprot id: G7PRE8
names: Similarity
messages: Belongs to the zyg-11 family.

9541:NUP93
gene id: 9541:NUP93
uniprot id: A0A2K5W1A6
uniprot id: G7Q166
uniprot id: Q4R8S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9541:MEGF8
gene id: 9541:MEGF8
uniprot id: A0A2K5VIM4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:NGDN
gene id: 9541:NGDN
uniprot id: A0A2K5V852
names: Subcellular Location Annotation
messages: nucleolus

9541:CMTR1
gene id: 9541:CMTR1
uniprot id: A0A2K5TZK3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with POLR2A (via C-terminus).
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9541:ANAPC15
gene id: 9541:ANAPC15
uniprot id: G7PR12
names: Similarity
messages: Belongs to the APC15 family.

9541:CSNK2A1
gene id: 9541:CSNK2A1
uniprot id: A0A2K5TL09
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:CSNK1G1
gene id: 9541:CSNK1G1
uniprot id: A0A2K5TZG2
uniprot id: A0A2K5TZH0
uniprot id: A0A2K5TZL5
uniprot id: A0A2K5TZN3
uniprot id: A0A7N9IBX7
uniprot id: A0A7N9IEM6
uniprot id: G8F3J7
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9541:HOXA7
gene id: 9541:HOXA7
uniprot id: A0A2K5UC88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9541:TMEM41A
gene id: 9541:TMEM41A
uniprot id: A0A2K5WJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9541:ECHDC2
gene id: 9541:ECHDC2
uniprot id: A0A2K5W0C9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9541:RAG2
gene id: 9541:RAG2
uniprot id: A0A2K5UMJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9541:SEPTIN10
gene id: 9541:SEPTIN10
uniprot id: A0A2K5VSH9
uniprot id: A0A2K5VSK9
uniprot id: A0A2K5VSL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:THTPA
gene id: 9541:THTPA
uniprot id: A0A2K5VF89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9541:EBAG9
gene id: 9541:EBAG9
uniprot id: A0A2K5UB51
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9541:AK5
gene id: 9541:AK5
uniprot id: A0A2K5VF31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9541:CDIP1
gene id: 9541:CDIP1
uniprot id: A0A2K5UQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9541:MARK2
gene id: 9541:MARK2
uniprot id: A0A2K5V4F5
uniprot id: A0A2K5V4G4
uniprot id: A0A2K5V4J1
uniprot id: A0A2K5V4L6
uniprot id: A0A7N9DD34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9541:PTPN2
gene id: 9541:PTPN2
uniprot id: A0A2K5VN47
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9541:KLC3
gene id: 9541:KLC3
uniprot id: A0A2K5WV81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9541:STN1
gene id: 9541:STN1
uniprot id: G7PDW8
uniprot id: Q4R804
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity).
messages: Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1; in the complex interacts directly with TEN1 and CTC1. Interacts with ACD/TPP1, POT1 and POLA1.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9541:SPATS2L
gene id: 9541:SPATS2L
uniprot id: A0A2K5WAB6
names: Similarity
messages: Belongs to the SPATS2 family.

9541:NRBP1
gene id: 9541:NRBP1
uniprot id: Q4R8X0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Endomembrane system
messages: Homodimer (By similarity). Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1 (By similarity). Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity). Interacts with ELOC/TCEB1, ELOB/TCEB2, TSC22D2 and TSC22D4 (By similarity). Interacts with the Elongin BC E3 ubiquitin ligase complex via its interaction with ELOB/TCEB2 and ELOC/TCEB1 (By similarity). Interacts with SALL4 (By similarity).
messages: Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (By similarity).
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cell cortex
messages: lamellipodium

9541:SPTBN1
gene id: 9541:SPTBN1
uniprot id: A0A2K5WAC7
names: Similarity
messages: Belongs to the spectrin family.

9541:GALNTL6
gene id: 9541:GALNTL6
uniprot id: A0A2K5W9R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:MTFP1
gene id: 9541:MTFP1
uniprot id: A0A8J8YHQ5
uniprot id: G7PF69
names: Similarity
messages: Belongs to the MTFP1 family.

9541:KCNJ16
gene id: 9541:KCNJ16
uniprot id: A0A7N9DCS8
uniprot id: A0A8J8XNL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9541:TXLNA
gene id: 9541:TXLNA
uniprot id: A0A2K5U644
uniprot id: G8F3T7
names: Similarity
messages: Belongs to the taxilin family.

9541:PHACTR1
gene id: 9541:PHACTR1
uniprot id: A0A7N9D260
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9541:DEFB132
gene id: 9541:DEFB132
uniprot id: A4H265
uniprot id: G7PGQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:PLAC8L1
gene id: 9541:PLAC8L1
uniprot id: A0A8J8XRF4
uniprot id: G7P8K5
names: Similarity
messages: Belongs to the cornifelin family.

9541:SYPL1
gene id: 9541:SYPL1
uniprot id: A0A2K5VY61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9541:FGF5
gene id: 9541:FGF5
uniprot id: A0A2K5WF43
uniprot id: A0A8J8Y8K5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:LOC102128529
gene id: 9541:LOC102128529
uniprot id: A0A8J8YPI1
uniprot id: G7P1L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9541:TNR
gene id: 9541:TNR
uniprot id: A0A2K5TRR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9541:TSSK6
gene id: 9541:TSSK6
uniprot id: A0A2K5TPA4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:HMBOX1
gene id: 9541:HMBOX1
uniprot id: A0A2K5V9Z2
uniprot id: A0A2K5V9Z7
uniprot id: A0A7N9D4V8
uniprot id: G7PD48
names: Subcellular Location Annotation
messages: Nucleus

9541:TMEM19
gene id: 9541:TMEM19
uniprot id: A0A2K5U1C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9541:ENTPD6
gene id: 9541:ENTPD6
uniprot id: A0A2K5TSX2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9541:SLC35A1
gene id: 9541:SLC35A1
uniprot id: A0A2K5U963
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:GAP43
gene id: 9541:GAP43
uniprot id: Q25G41
uniprot id: Q95K78
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts (via IQ domain) with calmodulin (By similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity).
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9541:WDR82
gene id: 9541:WDR82
uniprot id: A0A7N9CXF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9541:TCTA
gene id: 9541:TCTA
uniprot id: A0A2K5W833
uniprot id: G8F3M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9541:HNRNPK
gene id: 9541:HNRNPK
uniprot id: A0A2K5TNW0
uniprot id: Q4R4M6
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Interacts with ANKRD28, RBM42 and ZIK1. Interacts with DDX1. Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation. Interacts with p53/TP53. Interacts with BRDT (By similarity). Interacts with IVNS1ABP (By similarity). Interacts with PPIA/CYPA (By similarity). Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, ZNF827 and HNRNPL (By similarity).
messages: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
messages: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).
messages: Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions (By similarity).
messages: Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination (By similarity).
messages: nucleoplasm
messages: podosome

9541:ADGB
gene id: 9541:ADGB
uniprot id: A0A2K5V9S6
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SAMD4B
gene id: 9541:SAMD4B
uniprot id: A0A8J8YSU4
uniprot id: G7PXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9541:GLIPR1L1
gene id: 9541:GLIPR1L1
uniprot id: A0A2K5UUU6
names: Similarity
messages: Belongs to the CRISP family.

9541:CALHM5
gene id: 9541:CALHM5
uniprot id: A0A7N9CK87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9541:EIF5A
gene id: 9541:EIF5A
uniprot id: A0A2K5WME8
uniprot id: A0A2K5WMF8
uniprot id: G8F5Y2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

9541:TRIM25
gene id: 9541:TRIM25
uniprot id: A0A2K5WDN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9541:CYSLTR1
gene id: 9541:CYSLTR1
uniprot id: A0A7N9C8W6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:MAPKAPK3
gene id: 9541:MAPKAPK3
uniprot id: A0A2K5W9A9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:HOXC8
gene id: 9541:HOXC8
uniprot id: A0A8J8Y903
uniprot id: G7PHW1
names: Subcellular Location Annotation
messages: Nucleus

9541:NDUFAF2
gene id: 9541:NDUFAF2
uniprot id: A0A2K5WBD3
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9541:ADPRM
gene id: 9541:ADPRM
uniprot id: A0A8J8Y5L1
uniprot id: G7PTN6
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9541:AQP4
gene id: 9541:AQP4
uniprot id: A0A2K5WUH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9541:PPP4R3B
gene id: 9541:PPP4R3B
uniprot id: A0A2K5WJE9
uniprot id: A0A2K5WJI2
uniprot id: A0A8J8XJ84
uniprot id: G7PM87
names: Similarity
messages: Belongs to the SMEK family.

9541:NOX1
gene id: 9541:NOX1
uniprot id: A0A2K5VF08
uniprot id: A0A8J8XXT4
uniprot id: G7Q381
names: Subcellular Location Annotation
messages: Membrane

9541:NDUFV2
gene id: 9541:NDUFV2
uniprot id: A0A8J8Y2C7
uniprot id: G7PWD9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9541:IRF1
gene id: 9541:IRF1
uniprot id: A0A2K5U3M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9541:LOC102137003
gene id: 9541:LOC102137003
uniprot id: A0A2K5TT95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCC3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

9541:PLG
gene id: 9541:PLG
uniprot id: A0A2K5TJJ6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

9541:RPS26
gene id: 9541:RPS26
uniprot id: P61251
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the 40S small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9541:FAM118A
gene id: 9541:FAM118A
uniprot id: A0A2K5V3F1
uniprot id: A0A7N9CQ53
names: Similarity
messages: Belongs to the FAM118 family.

9541:NOP10
gene id: 9541:NOP10
uniprot id: A0A2K5UB95
names: Similarity
messages: Belongs to the NOP10 family.

9541:DCLRE1C
gene id: 9541:DCLRE1C
uniprot id: A0A2K5X8W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9541:LOC102117971
gene id: 9541:LOC102117971
uniprot id: A0A2K5UG48
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:HMCES
gene id: 9541:HMCES
uniprot id: A0A2K5V147
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9541:OXCT1
gene id: 9541:OXCT1
uniprot id: A0A2K5WEA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9541:SLC35A3
gene id: 9541:SLC35A3
uniprot id: A0A7N9CEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:CNEP1R1
gene id: 9541:CNEP1R1
uniprot id: A0A7N9D9L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9541:TOP1
gene id: 9541:TOP1
uniprot id: A0A2K5W1H4
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9541:CMC4
gene id: 9541:CMC4
uniprot id: A0A2K5WQX3
names: Similarity
messages: Belongs to the CMC4 family.

9541:C19H19orf54
gene id: 9541:C19H19orf54
uniprot id: A0A2K5W917
uniprot id: A0A7N9CGI7
names: Similarity
messages: Belongs to the ACTMAP family.

9541:AIFM1
gene id: 9541:AIFM1
uniprot id: A0A2K5X6Q3
uniprot id: A0A7N9CDH0
uniprot id: A0A8J8YM33
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9541:RXFP4
gene id: 9541:RXFP4
uniprot id: A0A2K5UN45
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:LOC102137625
gene id: 9541:LOC102137625
uniprot id: G7P2L6
uniprot id: G7P2P0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:EXOC6B
gene id: 9541:EXOC6B
uniprot id: A0A2K5V5C6
uniprot id: A0A7N9CB83
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9541:LYPD2
gene id: 9541:LYPD2
uniprot id: A0A2K5W0X5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:GPR33
gene id: 9541:GPR33
uniprot id: A0A7N9CK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9541:IP6K3
gene id: 9541:IP6K3
uniprot id: A0A2K5TQF7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9541:EIF4G3
gene id: 9541:EIF4G3
uniprot id: A0A2K5VAD7
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9541:TRPC1
gene id: 9541:TRPC1
uniprot id: A0A2K5U8P8
uniprot id: G7P008
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9541:LOC102125088
gene id: 9541:LOC102125088
uniprot id: A0A2K5UME9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9541:DEFB1
gene id: 9541:DEFB1
uniprot id: P61261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-defensin family.
messages: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
messages: Membrane
messages: Monomer. Homodimer.
messages: Secreted

9541:DHDDS
gene id: 9541:DHDDS
uniprot id: A0A2K5TPV3
uniprot id: A0A2K5TPX8
names: Similarity
messages: Belongs to the UPP synthase family.

9541:BTK
gene id: 9541:BTK
uniprot id: A0A2K5VDZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9541:LOC102134014
gene id: 9541:LOC102134014
uniprot id: A0A2K5UBG0
uniprot id: A0A2K5UH45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9541:CEBPG
gene id: 9541:CEBPG
uniprot id: A0A2K5UNS1
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

9541:LOC102123677
gene id: 9541:LOC102123677
uniprot id: A0A2K5W7N1
uniprot id: A0A2K5W7P1
uniprot id: A0A7N9DHH8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9541:GABARAPL1
gene id: 9541:GABARAPL1
uniprot id: A0A2K5X5D7
names: Similarity
messages: Belongs to the ATG8 family.

9541:THOC5
gene id: 9541:THOC5
uniprot id: A0A2K5U7V1
uniprot id: A0A2K5U7V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9541:NFYB
gene id: 9541:NFYB
uniprot id: A0A2K5TK75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

9541:PPY
gene id: 9541:PPY
uniprot id: A0A2K5TNU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9541:LOC102134628
gene id: 9541:LOC102134628
uniprot id: A0A2K5WS51
names: Similarity
messages: Belongs to the amidase family.

9541:SNX10
gene id: 9541:SNX10
uniprot id: A0A2K5X9H7
uniprot id: G7P0P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9541:KIN
gene id: 9541:KIN
uniprot id: A0A2K5U197
names: Similarity
messages: Belongs to the KIN17 family.

9541:PLK4
gene id: 9541:PLK4
uniprot id: A0A2K5W9E4
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: centriole

9541:IL13RA2
gene id: 9541:IL13RA2
uniprot id: A0A2K5WCT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.
messages: Membrane

9541:PPARA
gene id: 9541:PPARA
uniprot id: A0A8J8Y0L9
uniprot id: G7PFY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
messages: Nucleus

9541:LOC102146966
gene id: 9541:LOC102146966
uniprot id: A0A2K5TJM6
uniprot id: A0A7N9CDA4
names: Subcellular Location Annotation
messages: Nucleus

9541:PHKG2
gene id: 9541:PHKG2
uniprot id: A0A7N9CTB8
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9541:MLF1
gene id: 9541:MLF1
uniprot id: A0A2K5V446
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9541:IFT20
gene id: 9541:IFT20
uniprot id: G7PTW5
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9541:FAM234B
gene id: 9541:FAM234B
uniprot id: A0A2K5TQD1
names: Similarity
messages: Belongs to the FAM234 family.

9541:PIK3CD
gene id: 9541:PIK3CD
uniprot id: A0A7N9CY41
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9541:LOC102120132
gene id: 9541:LOC102120132
uniprot id: A0A0S4XKM2
uniprot id: Q4W7C7
names: Similarity
messages: Belongs to the MHC class I family.

9541:RIC8A
gene id: 9541:RIC8A
uniprot id: Q4R720
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).
messages: Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1. Interacts with NCS1; interaction is favored in the absence of Ca(2+) and myristoylation of NCS1 is not required (By similarity).

9541:SRM
gene id: 9541:SRM
uniprot id: A0A2K5WDB1
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9541:RTBDN
gene id: 9541:RTBDN
uniprot id: A0A7N9IFF7
names: Similarity
messages: Belongs to the folate receptor family.

9541:RHOT1
gene id: 9541:RHOT1
uniprot id: A0A2K5WGS5
uniprot id: A0A2K5WGS8
uniprot id: A0A2K5WGT8
uniprot id: A0A7N9CW05
uniprot id: A0A8J8Y5N8
uniprot id: G7PU10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9541:FCF1
gene id: 9541:FCF1
uniprot id: A0A2K5VFE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9541:NUP107
gene id: 9541:NUP107
uniprot id: A0A2K5V237
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

9541:LOC102124022
gene id: 9541:LOC102124022
uniprot id: A0A2K5WY34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9541:HNRNPD
gene id: 9541:HNRNPD
uniprot id: A0A2K5UXA5
uniprot id: A0A2K5UXI0
uniprot id: A0A7N9DEU8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:ATG3
gene id: 9541:ATG3
uniprot id: A0A8J8YPG7
uniprot id: G7NZS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG3 family.
messages: Cytoplasm

9541:ATL1
gene id: 9541:ATL1
uniprot id: A0A2K5X807
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9541:ODF1
gene id: 9541:ODF1
uniprot id: A0A2K5UBQ3
uniprot id: G8F3R8
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9541:RPE
gene id: 9541:RPE
uniprot id: A0A7N9CE89
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9541:JAKMIP1
gene id: 9541:JAKMIP1
uniprot id: A0A2K5VCL5
names: Similarity
messages: Belongs to the JAKMIP family.

9541:CCKAR
gene id: 9541:CCKAR
uniprot id: A0A2K5WAE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9541:TMEM255A
gene id: 9541:TMEM255A
uniprot id: A0A2K5TMD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9541:CAP2
gene id: 9541:CAP2
uniprot id: A0A2K5VWW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9541:TRAPPC6B
gene id: 9541:TRAPPC6B
uniprot id: A0A2K5TTI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9541:NKX2-2
gene id: 9541:NKX2-2
uniprot id: A0A2K5WFK2
names: Subcellular Location Annotation
messages: Nucleus

9541:EPHA5
gene id: 9541:EPHA5
uniprot id: A0A2K5W6J5
uniprot id: A0A2K5W6J6
uniprot id: A0A2K5W6M9
uniprot id: A0A7N9D0P2
names: Subcellular Location Annotation
messages: Membrane

9541:IDH3A
gene id: 9541:IDH3A
uniprot id: A0A2K5TMV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9541:SLC25A2
gene id: 9541:SLC25A2
uniprot id: A0A2K5UKR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:ANP32B
gene id: 9541:ANP32B
uniprot id: A0A2K5V4N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9541:EPHX1
gene id: 9541:EPHX1
uniprot id: G8F5S8
uniprot id: Q2PG24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9541:PROK1
gene id: 9541:PROK1
uniprot id: A0A2K5UMD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9541:LOC102145248
gene id: 9541:LOC102145248
uniprot id: A0A2K5X5X5
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9541:SLC52A2
gene id: 9541:SLC52A2
uniprot id: A0A2K5WSG3
uniprot id: G8F5V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9541:KAT7
gene id: 9541:KAT7
uniprot id: A0A2K5TSF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9541:KCNH6
gene id: 9541:KCNH6
uniprot id: A0A2K5X943
uniprot id: A0A2K5X9I4
names: Subcellular Location Annotation
messages: Membrane

9541:BTF3
gene id: 9541:BTF3
uniprot id: A0A2K5X8X8
names: Similarity
messages: Belongs to the NAC-beta family.

9541:CD40
gene id: 9541:CD40
uniprot id: A0A2K5V585
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:ECHDC1
gene id: 9541:ECHDC1
uniprot id: A0A2K5UN28
uniprot id: A0A2K5UN41
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9541:STEAP4
gene id: 9541:STEAP4
uniprot id: G7P1V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9541:GDI1
gene id: 9541:GDI1
uniprot id: A0A158SIP6
uniprot id: Q8HXX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Interacts with RHOH (By similarity). Interacts with the non-phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (By similarity).
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.
messages: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes (By similarity).
messages: trans-Golgi network

9541:NSG1
gene id: 9541:NSG1
uniprot id: Q4R5Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSG family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Forms a complex with GRIP1, GRIA2 and STX12 through direct interaction with GRIP1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with STX12 (By similarity). Interacts with APP; could regulate APP processing (By similarity). Interacts with FAM171A1 (By similarity).
messages: Golgi stack membrane
messages: Late endosome membrane
messages: Lysosome lumen
messages: Membrane
messages: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity).
messages: Recycling endosome membrane
messages: dendrite
messages: multivesicular body membrane
messages: trans-Golgi network membrane

9541:SNAPIN
gene id: 9541:SNAPIN
uniprot id: A0A2K5W620
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9541:NR2F2
gene id: 9541:NR2F2
uniprot id: A0A7N9D8M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:APOC3
gene id: 9541:APOC3
uniprot id: P18659
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
messages: Secreted
messages: The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.

9541:UPF3B
gene id: 9541:UPF3B
uniprot id: A0A2K5VTM2
uniprot id: A0A2K5VTM6
names: Similarity
messages: Belongs to the RENT3 family.

9541:GKAP1
gene id: 9541:GKAP1
uniprot id: A0A2K5TYX9
names: Similarity
messages: Belongs to the GKAP1 family.

9541:ARGLU1
gene id: 9541:ARGLU1
uniprot id: A0A8J8Y9C1
uniprot id: G7PVP8
names: Similarity
messages: Belongs to the UPF0430 family.

9541:CNIH2
gene id: 9541:CNIH2
uniprot id: A0A2K5W3C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9541:FOXP3
gene id: 9541:FOXP3
uniprot id: Q6U8D7
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Acetylation is mediated by a coordinated action of KAT5 and EP300/p300 acetyltransferases: EP300/p300 is required to enhance KAT5 autoacetylation, promoting acetylation of FOXP3 by KAT5. Deacetylated by SIRT1.
messages: Cytoplasm
messages: Homodimer. Dimerization is essential for its transcriptional regulator activity. Interacts with IKZF3. Interacts (via LXXLL motif) with RORA (via AF-2 motif). Interacts with HDAC9 in the absence of T-cell stimulation. Interacts with PPP1CA, PPP1CB, PPP1CG, KAT5, HDAC7, HSPA8, USP7, STUB1, HSPA1A/B, RUNX1, RUNX2, RUNX3, RELA, NFATC2, IKFZ4 and RORC.
messages: Nucleus
messages: Phosphorylation at Ser-418 regulates its transcriptional repressor activity and consequently, regulatory T-cells (Treg) suppressive function. Phosphorylation by CDK2 negatively regulates its transcriptional activity and protein stability.
messages: Polyubiquitinated, leading to its proteasomal degradation in regulatory T-cells (Treg) which is mediated by STUB1 in a HSPA1A/B-dependent manner. Deubiquitinated by USP7 and USP44 leading to increase in protein stability.
messages: The fork-head DNA-binding domain is essential for its dimerization and interaction with NFATC2.
messages: Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7. Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1. Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development. Inhibits the transcriptional activator activity of RORA (By similarity). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).
messages: Undergoes proteolytic cleavage in activated regulatory T-cells (Treg), and can be cleaved at either the N- or C-terminal site, or at both sites.

9541:AP3M1
gene id: 9541:AP3M1
uniprot id: A0A2K5VTF2
uniprot id: A0A8J8YQP0
uniprot id: G7PEZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9541:IPO11
gene id: 9541:IPO11
uniprot id: A0A2K5VA88
names: Subcellular Location Annotation
messages: Cytoplasm

9541:MAGOH
gene id: 9541:MAGOH
uniprot id: A0A8J8XPY4
uniprot id: G7NVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9541:GPR89A
gene id: 9541:GPR89A
uniprot id: A0A2K5U8Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9541:ACP5
gene id: 9541:ACP5
uniprot id: A0A2K5VSQ4
names: Cofactor
messages: Binds 2 iron ions per subunit.

9541:CLCN5
gene id: 9541:CLCN5
uniprot id: A0A2K5UX41
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:EXOC4
gene id: 9541:EXOC4
uniprot id: A0A2K5V2F7
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9541:GHSR
gene id: 9541:GHSR
uniprot id: A0A2K5WND3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ITGA2
gene id: 9541:ITGA2
uniprot id: A0A2K5UXK0
uniprot id: G8F2Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9541:SNRPE
gene id: 9541:SNRPE
uniprot id: A0A2K5WYY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9541:KRT20
gene id: 9541:KRT20
uniprot id: A0A8J8Y4V1
uniprot id: G7PUQ1
names: Similarity
messages: Belongs to the intermediate filament family.

9541:LOC102134935
gene id: 9541:LOC102134935
uniprot id: A0A2K5VGF4
uniprot id: A0A2K5VGH4
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9541:CDC26
gene id: 9541:CDC26
uniprot id: A0A8J8XAK7
uniprot id: G7PRM8
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9541:DYNLT1
gene id: 9541:DYNLT1
uniprot id: A0A2K5V8A7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9541:LYRM1
gene id: 9541:LYRM1
uniprot id: A0A2K5WA91
names: Similarity
messages: Belongs to the complex I LYR family.

9541:BCKDHA
gene id: 9541:BCKDHA
uniprot id: Q8HXY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.
messages: Mitochondrion matrix
messages: Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.

9541:SERBP1
gene id: 9541:SERBP1
uniprot id: A0A2K5X0J0
uniprot id: A0A7N9CX01
uniprot id: Q4R9B2
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

9541:CASQ2
gene id: 9541:CASQ2
uniprot id: A0A2K5W0H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9541:COQ9
gene id: 9541:COQ9
uniprot id: A0A7N9D679
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9541:WASF3
gene id: 9541:WASF3
uniprot id: A0A8J8YIG2
uniprot id: G7PVW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9541:EIF4H
gene id: 9541:EIF4H
uniprot id: A0A2K5UZ19
names: Function
names: Subcellular Location Annotation
messages: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
messages: perinuclear region

9541:GGPS1
gene id: 9541:GGPS1
uniprot id: A0A8J8XIY0
uniprot id: G7NXI9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9541:TPM3
gene id: 9541:TPM3
uniprot id: A0A2K5WHD1
uniprot id: A0A2K5WHI5
uniprot id: A0A2K5WHL3
uniprot id: A0A2K5WHN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9541:ARSI
gene id: 9541:ARSI
uniprot id: A0A2K5WH83
names: Similarity
messages: Belongs to the sulfatase family.

9541:C9
gene id: 9541:C9
uniprot id: A0A2K5X2W7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9541:NAT1
gene id: 9541:NAT1
uniprot id: A0A4Y1K7V2
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9541:RAP2C
gene id: 9541:RAP2C
uniprot id: A0A2K5V0X8
uniprot id: G8F3L7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9541:NTRK2
gene id: 9541:NTRK2
uniprot id: A0A2K5VS06
uniprot id: A0A2K5VS28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9541:HDAC5
gene id: 9541:HDAC5
uniprot id: A0A2K5VGF8
uniprot id: A0A2K5VGP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9541:ADGRG6
gene id: 9541:ADGRG6
uniprot id: A0A2K5U7W9
uniprot id: A0A2K5U7X0
uniprot id: A0A2K5U820
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:DEUP1
gene id: 9541:DEUP1
uniprot id: G7PNG4
uniprot id: Q95JK1
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CEP63 family.
messages: Contaminating sequence. Potential poly-A sequence. The C-terminus was extended based on orthologous sequences.
messages: Cytoplasm
messages: Interacts with CEP152; the interaction is mutually exclusive with CEP63.
messages: Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).

9541:FAM13B
gene id: 9541:FAM13B
uniprot id: A0A2K5X739
uniprot id: A0A2K5X7D0
uniprot id: G7P8D3
names: Similarity
messages: Belongs to the FAM13 family.

9541:PAQR4
gene id: 9541:PAQR4
uniprot id: A0A2K5WRA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:NDUFB5
gene id: 9541:NDUFB5
uniprot id: A0A2K5VYZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:CAMSAP2
gene id: 9541:CAMSAP2
uniprot id: A0A2K5WVP2
uniprot id: A0A2K5WVP7
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9541:DLX3
gene id: 9541:DLX3
uniprot id: A0A8J8YFU8
uniprot id: G7PU96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9541:ERRFI1
gene id: 9541:ERRFI1
uniprot id: A0A2K5VNH5
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9541:ITPR1
gene id: 9541:ITPR1
uniprot id: A0A2K5W261
uniprot id: A0A2K5W2H1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9541:AARS1
gene id: 9541:AARS1
uniprot id: A0A7N9CCE8
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9541:GRID2
gene id: 9541:GRID2
uniprot id: A0A2K5VGR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:LOC102126012
gene id: 9541:LOC102126012
uniprot id: A0A2K5U824
names: Similarity
messages: Belongs to the MS4A family.

9541:DRD1
gene id: 9541:DRD1
uniprot id: A0A8J8XEQ4
uniprot id: G7P6Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9541:FGF1
gene id: 9541:FGF1
uniprot id: A0A7N9ICC4
uniprot id: A0A8J8XW05
uniprot id: G7P8J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9541:RHOXF1
gene id: 9541:RHOXF1
uniprot id: A0A2K5TM98
names: Subcellular Location Annotation
messages: Nucleus

9541:SKAP1
gene id: 9541:SKAP1
uniprot id: A0A2K5WPA7
names: Similarity
messages: Belongs to the SKAP family.

9541:HSPA8
gene id: 9541:HSPA8
uniprot id: A0A2K5WNF9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9541:MSMB
gene id: 9541:MSMB
uniprot id: A0A2K5WFL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9541:IL17F
gene id: 9541:IL17F
uniprot id: A0A8J8XMV3
uniprot id: G7P4V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9541:LOC102127751
gene id: 9541:LOC102127751
uniprot id: A0A2K5VYJ1
uniprot id: A0A2K5VYL2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9541:SUPT16H
gene id: 9541:SUPT16H
uniprot id: A0A2K5VAC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9541:DGKA
gene id: 9541:DGKA
uniprot id: A0A8J8XJW0
uniprot id: G7PIF8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Monomer.

9541:LOC102130423
gene id: 9541:LOC102130423
uniprot id: A0A2K5WDR5
uniprot id: G8F456
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9541:LOC102117077
gene id: 9541:LOC102117077
uniprot id: Q8MHW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

9541:MAD1L1
gene id: 9541:MAD1L1
uniprot id: A0A2K5WQN7
uniprot id: A0A2K5WQR5
names: Similarity
messages: Belongs to the MAD1 family.

9541:TPD52
gene id: 9541:TPD52
uniprot id: A0A2K5UWA3
names: Similarity
messages: Belongs to the TPD52 family.

9541:EDIL3
gene id: 9541:EDIL3
uniprot id: A0A2K5WYU3
uniprot id: A0A2K5WYV1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:DPF2
gene id: 9541:DPF2
uniprot id: A0A2K5X8E9
names: Similarity
messages: Belongs to the requiem/DPF family.

9541:PPIL1
gene id: 9541:PPIL1
uniprot id: A0A2K5WSL3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9541:ARL3
gene id: 9541:ARL3
uniprot id: A0A7N9CAA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9541:RNF13
gene id: 9541:RNF13
uniprot id: A0A2K5WLV3
names: Subcellular Location Annotation
messages: Membrane

9541:PRKAR2B
gene id: 9541:PRKAR2B
uniprot id: A0A2K5WX89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9541:TMEM43
gene id: 9541:TMEM43
uniprot id: A0A7N9I9H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

9541:RHBDD3
gene id: 9541:RHBDD3
uniprot id: A0A2K5VHH7
names: Subcellular Location Annotation
messages: Membrane

9541:HOXB7
gene id: 9541:HOXB7
uniprot id: A0A8J8XEE4
uniprot id: G7PU75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9541:EFHC1
gene id: 9541:EFHC1
uniprot id: A0A2K5TJ25
names: Subcellular Location Annotation
messages: cilium axoneme

9541:ATP6V1D
gene id: 9541:ATP6V1D
uniprot id: Q4R702
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9541:RHBDD2
gene id: 9541:RHBDD2
uniprot id: A0A2K5W7I5
names: Subcellular Location Annotation
messages: Membrane

9541:GALNT10
gene id: 9541:GALNT10
uniprot id: A0A2K5VBM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:SPATS2
gene id: 9541:SPATS2
uniprot id: A0A2K5VZX1
names: Similarity
messages: Belongs to the SPATS2 family.

9541:PTGFR
gene id: 9541:PTGFR
uniprot id: A0A7N9D088
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:UBA52
gene id: 9541:UBA52
uniprot id: P0C273
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.
messages: Nucleus
messages: Part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).
messages: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.
messages: Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

9541:TPM1
gene id: 9541:TPM1
uniprot id: A0A2K5USQ3
uniprot id: A0A2K5USX5
uniprot id: A0A2K5UT06
uniprot id: A0A2K5UT88
uniprot id: I7GK41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9541:LGI1
gene id: 9541:LGI1
uniprot id: A0A2K5W5R5
uniprot id: A0A2K5W5V0
uniprot id: A0A8J8YCL6
names: Subcellular Location Annotation
messages: Secreted

9541:LETM2
gene id: 9541:LETM2
uniprot id: A0A8J8XD20
uniprot id: G7PD74
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

9541:GTF2B
gene id: 9541:GTF2B
uniprot id: A0A805PTU9
uniprot id: Q4R3J5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Autoacetylated; autoacetylation at Lys-238 stimulates transcription activation.
messages: Belongs to the TFIIB family.
messages: Chromosome
messages: Found in a ternary complex with TATA box-bound TBP. Part of a TFIID-containing RNA polymerase II pre-initiation complex (PIC) that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Associates with TFIID-TFIIA (DA complex) to form TFIID-TFIIA-TFIIB (DAB complex), which is then recognized by RNA polymerase II (Pol II). Found in a RNA polymerase II initiation complex. Interacts (via C-terminus) with TBP; this interaction with TATA box-bound TBP guides Pol II into the PIC. Interacts (via N-terminus) with Pol II. Interacts (via C-terminus) with SSU72; this interaction is inhibited by SYMPK. Interacts with NR2F1; this interaction is direct. Interacts with PGR. Interacts with ESR1. Interacts with GTF2F1 (via C-terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2. Interacts with GTF2F2 (via N-terminus); this interaction is inhibited in presence of GTF2F1. Interacts with the transcription elongation factor TCEA2. Interacts with HSF1 (via transactivation domain) (By similarity). Interacts with GPBP1 (By similarity).
messages: General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Exhibits also autoacetyltransferase activity that contributes to the activated transcription.
messages: Nucleus
messages: The TFIIB-type zinc-binding domain is necessary for the interaction and recruitment of RNA polymerase II to the core promoter, the formation of a fully competent pre-initiation complex (PIC) assembly and basal transcription initiation. The C-terminus is necessary and sufficient for interaction with the TATA box-bound TBP complex and for the formation of PIC.

9541:MEIS2
gene id: 9541:MEIS2
uniprot id: I7GEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9541:SLC27A4
gene id: 9541:SLC27A4
uniprot id: Q4R3Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Endoplasmic reticulum membrane
messages: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (By similarity). Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (By similarity). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).

9541:GRN
gene id: 9541:GRN
uniprot id: A0A2K5TL59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

9541:GNPDA1
gene id: 9541:GNPDA1
uniprot id: A0A2K5V5J5
uniprot id: A0A2K5V5N2
uniprot id: G7P8I9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9541:DNTTIP2
gene id: 9541:DNTTIP2
uniprot id: A0A2K5WA80
names: Subcellular Location Annotation
messages: nucleolus

9541:FER
gene id: 9541:FER
uniprot id: A0A2K5W0H6
uniprot id: A0A2K5W0I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9541:NANOS3
gene id: 9541:NANOS3
uniprot id: A0A7N9CX74
names: Similarity
messages: Belongs to the nanos family.

9541:NEURL2
gene id: 9541:NEURL2
uniprot id: A0A2K5X5N2
names: Subcellular Location Annotation
messages: Cytoplasm

9541:XRCC6
gene id: 9541:XRCC6
uniprot id: A0A8J8YAA5
uniprot id: Q4R673
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

9541:MED18
gene id: 9541:MED18
uniprot id: A0A2K5WHY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9541:CCNL1
gene id: 9541:CCNL1
uniprot id: A0A2K5UPJ8
names: Similarity
messages: Belongs to the cyclin family.

9541:ETHE1
gene id: 9541:ETHE1
uniprot id: G7PXS4
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9541:STXBP5
gene id: 9541:STXBP5
uniprot id: A0A2K5TXA1
uniprot id: A0A2K5TXC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9541:EIF3H
gene id: 9541:EIF3H
uniprot id: A0A2K5UCA2
uniprot id: A0A8J8Y043
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9541:MBL2
gene id: 9541:MBL2
uniprot id: Q66S50
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
messages: Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
messages: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).
messages: Secreted
messages: The coiled-coil domain mediates trimerization.

9541:DAND5
gene id: 9541:DAND5
uniprot id: A0A2K5X611
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9541:ST3GAL6
gene id: 9541:ST3GAL6
uniprot id: A0A2K5WZM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:CCNJ
gene id: 9541:CCNJ
uniprot id: A0A2K5WK04
names: Similarity
messages: Belongs to the cyclin family.

9541:CACNG7
gene id: 9541:CACNG7
uniprot id: A0A2K5UAN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

9541:CYP2R1
gene id: 9541:CYP2R1
uniprot id: A0A2K5TZ19
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:SGMS2
gene id: 9541:SGMS2
uniprot id: A0A8J8YSC0
uniprot id: G7P620
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9541:FAM13C
gene id: 9541:FAM13C
uniprot id: A0A2K5VNU4
names: Similarity
messages: Belongs to the FAM13 family.

9541:CHRM1
gene id: 9541:CHRM1
uniprot id: A0A2K5ULM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9541:BOLA3
gene id: 9541:BOLA3
uniprot id: A0A7N9CWH0
names: Similarity
messages: Belongs to the BolA/IbaG family.

9541:LOC102134053
gene id: 9541:LOC102134053
uniprot id: A0A2K5WWN3
names: Similarity
messages: Belongs to the histone H2B family.

9541:RPA3
gene id: 9541:RPA3
uniprot id: A0A2K5VY20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9541:MOGAT2
gene id: 9541:MOGAT2
uniprot id: A0A2K5V109
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TAAR2
gene id: 9541:TAAR2
uniprot id: G7P352
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:VEGFA
gene id: 9541:VEGFA
uniprot id: A0A7N9IDA9
uniprot id: Q95NE5
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9541:GABPA
gene id: 9541:GABPA
uniprot id: A0A8J8XLW7
uniprot id: G7P1M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:ISCA1
gene id: 9541:ISCA1
uniprot id: Q4R5F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Interacts with CRY2, but not with CRY1 (in vitro).
messages: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
messages: Mitochondrion

9541:LOC102131329
gene id: 9541:LOC102131329
uniprot id: A0A2K5V5Z9
names: Similarity
messages: Belongs to the TACO1 family.

9541:NBN
gene id: 9541:NBN
uniprot id: E5FGN1
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9541:NFKB1
gene id: 9541:NFKB1
uniprot id: A0A2K5TPZ9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:DEFB114
gene id: 9541:DEFB114
uniprot id: A0A2K5X4F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:SERPINB8
gene id: 9541:SERPINB8
uniprot id: A0A2K5V7F4
names: Similarity
messages: Belongs to the serpin family.

9541:RAB4A
gene id: 9541:RAB4A
uniprot id: A0A2K5WPN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9541:TTC39A
gene id: 9541:TTC39A
uniprot id: A0A2K5WJ45
names: Similarity
messages: Belongs to the TTC39 family.

9541:SOHLH1
gene id: 9541:SOHLH1
uniprot id: A0A2K5VRC0
names: Subcellular Location Annotation
messages: Nucleus

9541:VGLL1
gene id: 9541:VGLL1
uniprot id: A0A2K5VB36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9541:LOC102139875
gene id: 9541:LOC102139875
uniprot id: P61251
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the 40S small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

9541:CLN8
gene id: 9541:CLN8
uniprot id: A0A2K5VFP0
names: Subcellular Location Annotation
messages: Membrane

9541:APOE
gene id: 9541:APOE
uniprot id: A2V9Z3
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9541:ASF1A
gene id: 9541:ASF1A
uniprot id: A0A2K5VAE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9541:TP53INP1
gene id: 9541:TP53INP1
uniprot id: A0A2K5V686
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9541:UGT3A1
gene id: 9541:UGT3A1
uniprot id: A0A2K5WFL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9541:NCK2
gene id: 9541:NCK2
uniprot id: A0A2K5V8W2
uniprot id: A0A8J8YD01
uniprot id: G7PMW0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9541:DHRS9
gene id: 9541:DHRS9
uniprot id: A0A8J8XPG0
uniprot id: G7PKR5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:CCL11
gene id: 9541:CCL11
uniprot id: A0A2K5U1G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:GPCPD1
gene id: 9541:GPCPD1
uniprot id: A0A2K5W5R1
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9541:DEFB121
gene id: 9541:DEFB121
uniprot id: A0A8J8Y8S5
uniprot id: G7PGP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:CDCA8
gene id: 9541:CDCA8
uniprot id: A0A8J8XFX2
uniprot id: G7NUA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9541:VAMP1
gene id: 9541:VAMP1
uniprot id: A0A7N9IGI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9541:RNF146
gene id: 9541:RNF146
uniprot id: A0A2K5WVL0
uniprot id: A0A8J8YER2
uniprot id: Q2PFU6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation (By similarity).
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein (By similarity). Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity). Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity). Does not affect PARP1 activation. Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity). Promotes cell survival after gamma-irradiation. Facilitates DNA repair (By similarity).
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: Nucleus
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: Ubiquitinated; autoubiquitinated. Autoubiquitination is enhanced upon poly(ADP-ribose)-binding (By similarity).
messages: cytosol

9541:RAD9A
gene id: 9541:RAD9A
uniprot id: A0A2K5WVB6
names: Similarity
messages: Belongs to the rad9 family.

9541:TRIM46
gene id: 9541:TRIM46
uniprot id: A0A2K5TMA3
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

9541:EIF5B
gene id: 9541:EIF5B
uniprot id: A0A2K5WL63
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

9541:ZNF274
gene id: 9541:ZNF274
uniprot id: Q4R8H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Interacts with SETDB1 and TRIM28/KAP1. Interacts with ATRX. Forms a complex with ATRX, SETDB1 and TRIM28.
messages: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity).
messages: nucleolus

9541:FGF18
gene id: 9541:FGF18
uniprot id: A0A7N9IA32
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:GNL1
gene id: 9541:GNL1
uniprot id: Q4R8D2
names: Domain
names: Function
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family.
messages: In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
messages: Possible regulatory or functional link with the histocompatibility cluster.

9541:PDSS2
gene id: 9541:PDSS2
uniprot id: A0A8J8XRJ7
uniprot id: G7P454
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9541:CHPF2
gene id: 9541:CHPF2
uniprot id: A0A2K5WQU6
uniprot id: A0A2K5WQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9541:DGAT1
gene id: 9541:DGAT1
uniprot id: A0A2K5WCM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9541:ESD
gene id: 9541:ESD
uniprot id: A0A2K5V990
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9541:PFKM
gene id: 9541:PFKM
uniprot id: A0A7N9CDZ6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RNPS1
gene id: 9541:RNPS1
uniprot id: A0A2K5VYG9
uniprot id: G7Q091
uniprot id: Q4R5N1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Cytoplasm
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10 (By similarity).
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus
messages: Nucleus speckle
messages: Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity).
messages: Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro (By similarity).
messages: The RRM domain is required for the formation of the ASAP complex.

9541:PRPH2
gene id: 9541:PRPH2
uniprot id: A0A2K5WJM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9541:KEG98 p06
gene id: 9541:KEG98_p06
uniprot id: C3W4Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

9541:PARN
gene id: 9541:PARN
uniprot id: A0A7N9DBD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm

9541:PDE1A
gene id: 9541:PDE1A
uniprot id: A0A2K5WGG4
uniprot id: A0A2K5WGQ6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:VEPH1
gene id: 9541:VEPH1
uniprot id: A0A2K5VFK4
names: Similarity
messages: Belongs to the MELT/VEPH family.

9541:LTC4S
gene id: 9541:LTC4S
uniprot id: A0A7N9D4G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:CAV3
gene id: 9541:CAV3
uniprot id: A0A2K5WQ78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9541:ACTA1
gene id: 9541:ACTA1
uniprot id: A0A2K5TYP0
names: Similarity
messages: Belongs to the actin family.

9541:PNPO
gene id: 9541:PNPO
uniprot id: A0A2K5X2W4
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

9541:ARL5A
gene id: 9541:ARL5A
uniprot id: A0A2K5W621
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9541:S100A4
gene id: 9541:S100A4
uniprot id: A0A2K5WBB8
uniprot id: A0A8J8Y4J9
names: Similarity
messages: Belongs to the S-100 family.

9541:ZNF711
gene id: 9541:ZNF711
uniprot id: A0A2K5W5G0
uniprot id: A0A8J8YJG0
uniprot id: G7Q360
names: Subcellular Location Annotation
messages: Nucleus

9541:GTF2A2
gene id: 9541:GTF2A2
uniprot id: A0A2K5WHM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9541:ETF1
gene id: 9541:ETF1
uniprot id: A0A2K5WYH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9541:MFSD11
gene id: 9541:MFSD11
uniprot id: G7PSW8
uniprot id: Q4R495
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Despite its name it is related to the unc-93 family and not to the major facilitator superfamily.
messages: Membrane

9541:FFAR1
gene id: 9541:FFAR1
uniprot id: Q76JV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.

9541:FBXO48
gene id: 9541:FBXO48
uniprot id: A0A8J8Y3S8
uniprot id: G7PMC8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9541:PAQR5
gene id: 9541:PAQR5
uniprot id: A0A8J8YRD9
uniprot id: G7P902
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:MRPL47
gene id: 9541:MRPL47
uniprot id: A0A7N9DBX8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9541:PDE6H
gene id: 9541:PDE6H
uniprot id: A0A8J8YH66
uniprot id: G7PJY4
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9541:MAPRE1
gene id: 9541:MAPRE1
uniprot id: A0A2K5UDS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9541:MFSD14B
gene id: 9541:MFSD14B
uniprot id: A0A2K5VC27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9541:LOC102131262
gene id: 9541:LOC102131262
uniprot id: A0A2K5UDT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:LYRM2
gene id: 9541:LYRM2
uniprot id: A0A7N9IHI7
names: Similarity
messages: Belongs to the complex I LYR family.

9541:TLL1
gene id: 9541:TLL1
uniprot id: A0A2K5U8M4
uniprot id: A0A2K5U8R3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:XRN2
gene id: 9541:XRN2
uniprot id: A0A2K5WKV6
uniprot id: A0A8J8YIF4
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9541:TAC1
gene id: 9541:TAC1
uniprot id: A0A2K5X6I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9541:KCNS2
gene id: 9541:KCNS2
uniprot id: A0A2K5UQH5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:ACAD9
gene id: 9541:ACAD9
uniprot id: A0A2K5VRB8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9541:CAPN12
gene id: 9541:CAPN12
uniprot id: Q4R721
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:GORASP1
gene id: 9541:GORASP1
uniprot id: A0A2K5X944
names: Similarity
messages: Belongs to the GORASP family.

9541:OGDH
gene id: 9541:OGDH
uniprot id: A0A2K5VYI5
uniprot id: A0A2K5VYM0
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9541:LIN28A
gene id: 9541:LIN28A
uniprot id: A0A7N9IH37
names: Similarity
messages: Belongs to the lin-28 family.

9541:GNAO1
gene id: 9541:GNAO1
uniprot id: A0A2K5V3X8
uniprot id: A0A2K5V415
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9541:ANAPC5
gene id: 9541:ANAPC5
uniprot id: A0A2K5U3D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9541:IMP3
gene id: 9541:IMP3
uniprot id: A0A2K5UE45
uniprot id: G8F2V1
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9541:PTGES3
gene id: 9541:PTGES3
uniprot id: I7GKX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9541:EPN2
gene id: 9541:EPN2
uniprot id: A0A2K5WRE9
uniprot id: A0A2K5WRF8
names: Similarity
messages: Belongs to the epsin family.

9541:LOC102125186
gene id: 9541:LOC102125186
uniprot id: Q4R882
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:DKK1
gene id: 9541:DKK1
uniprot id: A0A2K5WMC3
uniprot id: A0A7N9IE82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9541:CHRNA2
gene id: 9541:CHRNA2
uniprot id: A0A2K5WB27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:MS4A7
gene id: 9541:MS4A7
uniprot id: A0A2K5WQ04
names: Similarity
messages: Belongs to the MS4A family.

9541:LARP7
gene id: 9541:LARP7
uniprot id: Q4R627
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LARP7 family.
messages: Core component of the 7SK RNP complex, at least composed of 7SK RNA, LARP7, MEPCE, HEXIM1 (or HEXIM2) and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1). Interacts with METTL16. Interacts with RBM7; upon genotoxic stress this interaction is enhanced, triggering the release of inactive P-TEFb complex from the core, yielding to P-TEFb complex activation. Associates with box C/D small nucleolar ribonucleoprotein (snoRNP) complexes.
messages: RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (By similarity). U6 snRNA processing is required for spermatogenesis (By similarity).
messages: The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.
messages: nucleoplasm

9541:MRPL16
gene id: 9541:MRPL16
uniprot id: A0A2K5TZC6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9541:CCL13
gene id: 9541:CCL13
uniprot id: A0A8J8YKY5
uniprot id: G7PU25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:APH1A
gene id: 9541:APH1A
uniprot id: A0A2K5U529
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9541:CIBAR1
gene id: 9541:CIBAR1
uniprot id: A0A2K5V3T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole
messages: cilium basal body

9541:C2
gene id: 9541:C2
uniprot id: A0A2K5U0I4
uniprot id: G8F3W0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:ABRAXAS1
gene id: 9541:ABRAXAS1
uniprot id: A0A2K5X6M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Nucleus

9541:TIMM22
gene id: 9541:TIMM22
uniprot id: A0A2K5UUL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9541:ESR1
gene id: 9541:ESR1
uniprot id: A0A8J8XH51
uniprot id: G7P4Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

9541:SLC25A17
gene id: 9541:SLC25A17
uniprot id: A0A2K5VCR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:LOC102136362
gene id: 9541:LOC102136362
uniprot id: A0A2K5W4L0
names: Similarity
messages: Belongs to the calcitonin family.

9541:VPS33B
gene id: 9541:VPS33B
uniprot id: A0A2K5V6T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9541:LMNA
gene id: 9541:LMNA
uniprot id: A0A8J8YBF0
uniprot id: G7NV78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9541:CD99L2
gene id: 9541:CD99L2
uniprot id: A0A2K5VGR7
uniprot id: A0A2K5VGY7
names: Similarity
messages: Belongs to the CD99 family.

9541:ARHGEF2
gene id: 9541:ARHGEF2
uniprot id: A0A2K5UCY5
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

9541:CEPT1
gene id: 9541:CEPT1
uniprot id: A0A2K5VL08
uniprot id: A0A2K5VL10
uniprot id: A0A8J8YNT5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9541:ITGB3
gene id: 9541:ITGB3
uniprot id: A0A2K5WYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9541:PRKG1
gene id: 9541:PRKG1
uniprot id: A0A2K5VZ44
uniprot id: A0A2K5VZ60
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9541:FCGRT
gene id: 9541:FCGRT
uniprot id: Q8SPV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.
messages: Endosome membrane
messages: FcRn complex consists of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity). Interacts with albumin/ALB; this interaction regulates ALB homeostasis (By similarity).

9541:IL22
gene id: 9541:IL22
uniprot id: A0A8J8XHW8
uniprot id: G7PHZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

9541:TMEM126A
gene id: 9541:TMEM126A
uniprot id: A0A8J8YQX2
uniprot id: G7PND4
names: Subcellular Location Annotation
messages: Membrane

9541:FBXO15
gene id: 9541:FBXO15
uniprot id: Q9GKV7
names: Function
names: Subunit
messages: Directly interacts with SKP1 and CUL1.
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9541:HMOX2
gene id: 9541:HMOX2
uniprot id: A0A8J8YHX2
uniprot id: G7Q0E3
names: Similarity
messages: Belongs to the heme oxygenase family.

9541:KCNJ10
gene id: 9541:KCNJ10
uniprot id: G7NWC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9541:CCT8
gene id: 9541:CCT8
uniprot id: A0A2K5VA28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: cilium basal body

9541:TRIM69
gene id: 9541:TRIM69
uniprot id: A0A2K5X0Q5
names: Subcellular Location Annotation
messages: Cytoplasm

9541:RPRD1B
gene id: 9541:RPRD1B
uniprot id: A0A8J8YRX8
uniprot id: G7PGE9
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9541:PDLIM3
gene id: 9541:PDLIM3
uniprot id: A0A2K5U1J5
uniprot id: A0A2K5U1K1
names: Subcellular Location Annotation
messages: Z line

9541:MT1E
gene id: 9541:MT1E
uniprot id: G7Q165
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9541:IQCD
gene id: 9541:IQCD
uniprot id: A0A2K5TTU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9541:DEDD
gene id: 9541:DEDD
uniprot id: A0A8J8XXP3
uniprot id: G7NXA0
names: Subcellular Location Annotation
messages: nucleolus

9541:RNASEH2A
gene id: 9541:RNASEH2A
uniprot id: A0A7N9IAX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9541:TINAG
gene id: 9541:TINAG
uniprot id: A0A2K5VFX9
names: Similarity
messages: Belongs to the peptidase C1 family.

9541:ARL6
gene id: 9541:ARL6
uniprot id: A0A2K5VB91
uniprot id: A0A8J8XKV2
uniprot id: G7NZ67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9541:MS4A13
gene id: 9541:MS4A13
uniprot id: G7PPZ9
names: Similarity
messages: Belongs to the MS4A family.

9541:GPATCH11
gene id: 9541:GPATCH11
uniprot id: A0A2K5VEM5
names: Similarity
messages: Belongs to the GPATCH11 family.

9541:CCR5
gene id: 9541:CCR5
uniprot id: A0A2K5W5W1
names: Similarity
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis.

9541:ITM2A
gene id: 9541:ITM2A
uniprot id: A0A2K5WKG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9541:RELL2
gene id: 9541:RELL2
uniprot id: A0A2K5V7N4
names: Similarity
messages: Belongs to the RELT family.

9541:VPS28
gene id: 9541:VPS28
uniprot id: A0A7N9CK83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
messages: Membrane

9541:SDR42E1
gene id: 9541:SDR42E1
uniprot id: G7PZU6
uniprot id: Q4R7R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-beta-HSD family.
messages: Membrane

9541:LOC102143165
gene id: 9541:LOC102143165
uniprot id: A0A8J8YAT7
uniprot id: G7PQY2
names: Similarity
messages: Belongs to the globin family.

9541:TRAF1
gene id: 9541:TRAF1
uniprot id: A0A2K5UUH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9541:ABRACL
gene id: 9541:ABRACL
uniprot id: A0A2K5WRC0
names: Similarity
messages: Belongs to the costars family.

9541:IDE
gene id: 9541:IDE
uniprot id: A0A2K5TUD2
names: Similarity
messages: Belongs to the peptidase M16 family.

9541:LPL
gene id: 9541:LPL
uniprot id: A0A7N9D851
uniprot id: I7GCW6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9541:TBPL1
gene id: 9541:TBPL1
uniprot id: Q4R848
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.
messages: Cytoplasm
messages: Nucleus
messages: Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity).

9541:RAB3C
gene id: 9541:RAB3C
uniprot id: A0A7N9CIY2
uniprot id: A0A8J8XFS3
uniprot id: G7P7K2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9541:NUDT4
gene id: 9541:NUDT4
uniprot id: A0A7N9I9E1
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9541:SEC11A
gene id: 9541:SEC11A
uniprot id: A0A2K5TS20
uniprot id: A0A2K5TS29
uniprot id: A0A2K5TS41
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:COPG2
gene id: 9541:COPG2
uniprot id: A0A2K5U893
uniprot id: A0A7N9IBS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9541:IRF2
gene id: 9541:IRF2
uniprot id: A0A2K5WXX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9541:ATP6V1H
gene id: 9541:ATP6V1H
uniprot id: A0A2K5V7B1
uniprot id: A0A8J8Y9P5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:RPL26L1
gene id: 9541:RPL26L1
uniprot id: A0A2K5W0P7
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9541:GPAM
gene id: 9541:GPAM
uniprot id: A0A2K5V1Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9541:SLC7A1
gene id: 9541:SLC7A1
uniprot id: A0A8J8XU70
uniprot id: G7PVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9541:DCTN6
gene id: 9541:DCTN6
uniprot id: A0A2K5WV70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: cytoskeleton

9541:CBR3
gene id: 9541:CBR3
uniprot id: A0A2K5UW11
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9541:DPT
gene id: 9541:DPT
uniprot id: A0A2K5VRK7
names: Similarity
messages: Belongs to the dermatopontin family.

9541:RARS1
gene id: 9541:RARS1
uniprot id: A0A8J8XGN1
uniprot id: G7P6U6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:NOTCH2
gene id: 9541:NOTCH2
uniprot id: A0A2K5U7P6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9541:SFMBT1
gene id: 9541:SFMBT1
uniprot id: A0A2K5W642
names: Subcellular Location Annotation
messages: Nucleus

9541:MLST8
gene id: 9541:MLST8
uniprot id: A0A2K5VVA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9541:CNIH3
gene id: 9541:CNIH3
uniprot id: A0A2K5TRJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9541:ATP2A2
gene id: 9541:ATP2A2
uniprot id: A0A2K5URR3
uniprot id: A0A2K5URW4
uniprot id: A0A7N9D608
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9541:SLC13A3
gene id: 9541:SLC13A3
uniprot id: A0A2K5W5G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9541:SH3BP5L
gene id: 9541:SH3BP5L
uniprot id: A0A2K5WLD2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9541:HMGN4
gene id: 9541:HMGN4
uniprot id: A0A7N9CUD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9541:LOC102145605
gene id: 9541:LOC102145605
uniprot id: A0A2K5WYE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9541:CENPK
gene id: 9541:CENPK
uniprot id: A0A8J8Y6U8
uniprot id: G7P7M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9541:GLA
gene id: 9541:GLA
uniprot id: A0A2K5V2Q7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9541:PTCD2
gene id: 9541:PTCD2
uniprot id: A0A7N9CFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

9541:TMBIM6
gene id: 9541:TMBIM6
uniprot id: I7GKH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9541:PDCD10
gene id: 9541:PDCD10
uniprot id: A0A2K5VRK1
uniprot id: A0A979HKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9541:IL6
gene id: 9541:IL6
uniprot id: G7P0R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9541:PAX6
gene id: 9541:PAX6
uniprot id: A0A2K5UK65
uniprot id: I7G9J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9541:PSMB1
gene id: 9541:PSMB1
uniprot id: A0A8J8XGD3
uniprot id: G7P4A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9541:TMEM161B
gene id: 9541:TMEM161B
uniprot id: A0A2K5VDR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9541:LOC102146235
gene id: 9541:LOC102146235
uniprot id: A0A2K5W6Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9541:TSPAN31
gene id: 9541:TSPAN31
uniprot id: A0A2K5UP83
uniprot id: A0A8J8Y0F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:HYAL3
gene id: 9541:HYAL3
uniprot id: A0A2K5VGW3
uniprot id: A0A2K5VH22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.
messages: Membrane
messages: acrosome

9541:SEC24C
gene id: 9541:SEC24C
uniprot id: A0A2K5U7M0
uniprot id: A0A7N9D9T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9541:BST1
gene id: 9541:BST1
uniprot id: E5G6H5
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9541:KIF9
gene id: 9541:KIF9
uniprot id: A0A2K5VJ68
uniprot id: A0A8J8YN76
uniprot id: G7NXW4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:DDIT4L
gene id: 9541:DDIT4L
uniprot id: A0A8J8XRQ5
uniprot id: G7P5Z9
names: Similarity
messages: Belongs to the DDIT4 family.

9541:ATG101
gene id: 9541:ATG101
uniprot id: A0A8J8YC85
uniprot id: G7PIC2
names: Similarity
messages: Belongs to the ATG101 family.

9541:KCNJ6
gene id: 9541:KCNJ6
uniprot id: A0A2K5X5N4
uniprot id: A0A8J8XP04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9541:LOC102133077
gene id: 9541:LOC102133077
uniprot id: G8F3F9
names: Similarity
messages: Belongs to the LCE family.

9541:GABBR1
gene id: 9541:GABBR1
uniprot id: A0A2K5TNP9
uniprot id: A0A7N9DEY1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:ZDHHC2
gene id: 9541:ZDHHC2
uniprot id: A0A2K5W3H3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:LSM2
gene id: 9541:LSM2
uniprot id: A0A2K5U9H6
uniprot id: G8F3W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9541:MBTD1
gene id: 9541:MBTD1
uniprot id: A0A2K5TRD0
names: Subcellular Location Annotation
messages: Nucleus

9541:CX3CR1
gene id: 9541:CX3CR1
uniprot id: A0A2K5VJQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9541:EPHA7
gene id: 9541:EPHA7
uniprot id: A0A8J8XWR7
uniprot id: G7P422
names: Subcellular Location Annotation
messages: Membrane

9541:ZHX1
gene id: 9541:ZHX1
uniprot id: A0A2K5UIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9541:UBE2D3
gene id: 9541:UBE2D3
uniprot id: A0A2K5W840
uniprot id: Q4R5N4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production. Together with ZNF598, catalyzes ubiquitination of 40S ribosomal proteins in response to ribosome collisions. In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Cell membrane
messages: Endosome membrane
messages: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with ubiquitin. Interacts with E3 ubiquitin-protein ligase CBLC. Interacts with UBTD1 (By similarity). Interacts with RIGI and RNF135; involved in RIGI ubiquitination and activation (By similarity).
messages: Phosphorylated by AURKB.

9541:FXYD4
gene id: 9541:FXYD4
uniprot id: A0A7N9DEE3
uniprot id: A0A8J8YJX1
uniprot id: G7PER3
names: Similarity
messages: Belongs to the FXYD family.

9541:TNPO1
gene id: 9541:TNPO1
uniprot id: A0A2K5WCI7
uniprot id: A0A2K5WCL6
names: Subcellular Location Annotation
messages: Cytoplasm

9541:RNF5
gene id: 9541:RNF5
uniprot id: A0A2K5V7H0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9541:STAC
gene id: 9541:STAC
uniprot id: A0A7N9CCB6
names: Subcellular Location Annotation
messages: sarcolemma

9541:SCGB1A1
gene id: 9541:SCGB1A1
uniprot id: A0A8J8YH17
uniprot id: G7PPU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9541:ART3
gene id: 9541:ART3
uniprot id: A0A2K5TMJ0
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9541:PON3
gene id: 9541:PON3
uniprot id: A0A2K5WNZ3
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9541:ETV4
gene id: 9541:ETV4
uniprot id: A0A2K5W122
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:ESRRA
gene id: 9541:ESRRA
uniprot id: A0A2K5VB75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9541:SMG8
gene id: 9541:SMG8
uniprot id: A0A8J8Y4H0
uniprot id: G7PUG9
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

9541:KEG98 p12
gene id: 9541:KEG98_p12
uniprot id: C3W4Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9541:DCTN4
gene id: 9541:DCTN4
uniprot id: A0A2K5W558
uniprot id: A0A8J8YS99
uniprot id: G7P8Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: cell cortex
messages: centrosome
messages: sarcomere
messages: stress fiber

9541:RFC5
gene id: 9541:RFC5
uniprot id: A0A2K5VKM6
uniprot id: G8F2Q2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9541:HCAR1
gene id: 9541:HCAR1
uniprot id: A0A2K5ULI6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:LOC102146577
gene id: 9541:LOC102146577
uniprot id: A0A2K5UJS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9541:NDUFA1
gene id: 9541:NDUFA1
uniprot id: A0A2K5WX98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:F10
gene id: 9541:F10
uniprot id: A0A2K5VHK1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:LOC102136791
gene id: 9541:LOC102136791
uniprot id: A0A2K5V173
uniprot id: A0A2K5V183
uniprot id: A0A2K5V186
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9541:FGF20
gene id: 9541:FGF20
uniprot id: A0A2K5VCR8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:ZC3H12A
gene id: 9541:ZC3H12A
uniprot id: A0A2K5V3E9
names: Similarity
messages: Belongs to the ZC3H12 family.

9541:LBX2
gene id: 9541:LBX2
uniprot id: A0A2K5VFD2
names: Subcellular Location Annotation
messages: Nucleus

9541:PEX13
gene id: 9541:PEX13
uniprot id: A0A2K5VCM6
names: Similarity
messages: Belongs to the peroxin-13 family.

9541:RPSA
gene id: 9541:RPSA
uniprot id: I7G7S3
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9541:EIF2A
gene id: 9541:EIF2A
uniprot id: A0A8J8Y686
uniprot id: G7NZM4
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9541:LOC102122931
gene id: 9541:LOC102122931
uniprot id: A0A7N9D2E9
names: Subcellular Location Annotation
messages: Membrane

9541:HDAC3
gene id: 9541:HDAC3
uniprot id: A0A2K5U0C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9541:LOC102144583
gene id: 9541:LOC102144583
uniprot id: A0A8J8YCN9
uniprot id: G7NTR6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:SS18
gene id: 9541:SS18
uniprot id: A0A2K5VBW7
names: Similarity
messages: Belongs to the SS18 family.

9541:DLST
gene id: 9541:DLST
uniprot id: A0A2K5UP28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9541:CORO2A
gene id: 9541:CORO2A
uniprot id: A0A2K5UKF1
names: Similarity
messages: Belongs to the WD repeat coronin family.

9541:CPSF2
gene id: 9541:CPSF2
uniprot id: A0A8J8YIL5
uniprot id: G7PBB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9541:TSG101
gene id: 9541:TSG101
uniprot id: A0A8J8YL06
uniprot id: G7PQL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Membrane

9541:PGM5
gene id: 9541:PGM5
uniprot id: A0A2K5VRN8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9541:PEX3
gene id: 9541:PEX3
uniprot id: G7P307
uniprot id: Q60HE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-3 family.
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (By similarity).
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9541:MGAT4D
gene id: 9541:MGAT4D
uniprot id: A0A2K5W3K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane

9541:TPD52L1
gene id: 9541:TPD52L1
uniprot id: A0A2K5X0K9
uniprot id: A0A2K5X0T1
uniprot id: A0A2K5X0W8
uniprot id: A0A2K5X164
uniprot id: A0A8J8XXK1
names: Similarity
messages: Belongs to the TPD52 family.

9541:CEP170
gene id: 9541:CEP170
uniprot id: A0A2K5U0P2
names: Similarity
messages: Belongs to the CEP170 family.

9541:LOC107129595
gene id: 9541:LOC107129595
uniprot id: G7P2N0
uniprot id: Q4R362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9541:LOC102116377
gene id: 9541:LOC102116377
uniprot id: A0A2K5X1H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9541:NUDT2
gene id: 9541:NUDT2
uniprot id: A0A2K5U315
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9541:DEGS2
gene id: 9541:DEGS2
uniprot id: A0A2K5VGY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LOC102131576
gene id: 9541:LOC102131576
uniprot id: A0A2K5UGV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9541:DCP1A
gene id: 9541:DCP1A
uniprot id: A0A2K5WI42
names: Similarity
messages: Belongs to the DCP1 family.

9541:SGMS1
gene id: 9541:SGMS1
uniprot id: A0A2K5TZB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9541:LOC102118097
gene id: 9541:LOC102118097
uniprot id: A0A8U0WQ25
uniprot id: G8F3V0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:ANAPC16
gene id: 9541:ANAPC16
uniprot id: A0A2K5X5W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9541:PABPC4
gene id: 9541:PABPC4
uniprot id: A0A2K5WWH5
uniprot id: A0A2K5WWI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9541:TMSB15B
gene id: 9541:TMSB15B
uniprot id: A0A8J8XD17
uniprot id: G7Q3A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9541:SSTR1
gene id: 9541:SSTR1
uniprot id: A0A2K5UEB0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:AMT
gene id: 9541:AMT
uniprot id: A0A2K5WBL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9541:PIGS
gene id: 9541:PIGS
uniprot id: A0A8J8YJ93
uniprot id: G7PTX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:PRKACA
gene id: 9541:PRKACA
uniprot id: A0A2K5UC31
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9541:OGDHL
gene id: 9541:OGDHL
uniprot id: A0A2K5UXT3
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9541:GLRA3
gene id: 9541:GLRA3
uniprot id: A0A2K5WH11
uniprot id: A0A2K5WH44
uniprot id: A0A8J8Y2D0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9541:DUXA
gene id: 9541:DUXA
uniprot id: A0A2K5VE58
names: Subcellular Location Annotation
messages: Nucleus

9541:TNS4
gene id: 9541:TNS4
uniprot id: A0A2K5TUF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9541:PCK2
gene id: 9541:PCK2
uniprot id: A0A2K5W9M9
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Monomer.

9541:CLIC4
gene id: 9541:CLIC4
uniprot id: A0A2K5WP59
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9541:MC1R
gene id: 9541:MC1R
uniprot id: A3KF54
uniprot id: A3KF60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.

9541:WASHC5
gene id: 9541:WASHC5
uniprot id: A0A2K5UU23
names: Similarity
messages: Belongs to the strumpellin family.

9541:EFNB3
gene id: 9541:EFNB3
uniprot id: A0A7N9CSQ9
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:OTULIN
gene id: 9541:OTULIN
uniprot id: A0A2K5WJB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9541:LOC102124421
gene id: 9541:LOC102124421
uniprot id: A0A2K5X7N0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.

9541:TUBA1C
gene id: 9541:TUBA1C
uniprot id: A0A805QYG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9541:FIP1L1
gene id: 9541:FIP1L1
uniprot id: A0A2K5W1Z4
uniprot id: A0A2K5W200
uniprot id: A0A2K5W202
uniprot id: A0A2K5W211
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9541:DDX43
gene id: 9541:DDX43
uniprot id: A0A2K5VDJ5
names: Similarity
messages: Belongs to the DEAD box helicase family.

9541:TSHB
gene id: 9541:TSHB
uniprot id: A0A2K5X6T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9541:RPL10
gene id: 9541:RPL10
uniprot id: A0A8J8XDM4
uniprot id: G7Q3B3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9541:IMPG2
gene id: 9541:IMPG2
uniprot id: A0A2K5V0I2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: interphotoreceptor matrix

9541:SLC25A26
gene id: 9541:SLC25A26
uniprot id: I7GN77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:C7
gene id: 9541:C7
uniprot id: A0A7N9IA03
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:PCBD1
gene id: 9541:PCBD1
uniprot id: A0A2K5U618
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9541:NR1D1
gene id: 9541:NR1D1
uniprot id: A0A2K5WKV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:NXF1
gene id: 9541:NXF1
uniprot id: A0A2K5VTR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9541:RAB39A
gene id: 9541:RAB39A
uniprot id: A0A2K5VG96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9541:STK32A
gene id: 9541:STK32A
uniprot id: A0A2K5UD14
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:HSPA5
gene id: 9541:HSPA5
uniprot id: A0A2K5WXY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cell surface
messages: Endoplasmic reticulum lumen
messages: Melanosome

9541:RDH11
gene id: 9541:RDH11
uniprot id: G8F2I0
uniprot id: Q4JK72
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:SCMH1
gene id: 9541:SCMH1
uniprot id: A0A2K5W3S2
uniprot id: A0A2K5W3U6
uniprot id: A0A2K5W3U7
uniprot id: A0A8J8YP52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9541:LOC102144275
gene id: 9541:LOC102144275
uniprot id: A0A2K5V3P5
names: Similarity
messages: Belongs to the SEC2 family.

9541:PAGE2B
gene id: 9541:PAGE2B
uniprot id: A0A2K5W4M5
names: Similarity
messages: Belongs to the GAGE family.

9541:LOC102120633
gene id: 9541:LOC102120633
uniprot id: A0A2K5X1W8
uniprot id: A0A7N9CB00
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9541:RSPO2
gene id: 9541:RSPO2
uniprot id: A0A8J8Y480
uniprot id: G7PCH9
names: Similarity
messages: Belongs to the R-spondin family.

9541:PAQR8
gene id: 9541:PAQR8
uniprot id: A0A2K5UC52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:RPL22L1
gene id: 9541:RPL22L1
uniprot id: A0A2K5WVQ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9541:SFXN1
gene id: 9541:SFXN1
uniprot id: A0A2K5U2P2
uniprot id: A0A8J8XHZ4
uniprot id: G7P6Y2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9541:SDHAF4
gene id: 9541:SDHAF4
uniprot id: A0A8J8YBD7
uniprot id: G7P2Z8
names: Similarity
messages: Belongs to the SDHAF4 family.

9541:IGF2BP3
gene id: 9541:IGF2BP3
uniprot id: A0A7N9CA49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9541:RANGRF
gene id: 9541:RANGRF
uniprot id: A0A2K5VH47
uniprot id: A0A2K5VHA4
names: Similarity
messages: Belongs to the MOG1 family.

9541:WARS2
gene id: 9541:WARS2
uniprot id: G7NX63
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:TMEM106A
gene id: 9541:TMEM106A
uniprot id: A0A2K5UZ61
uniprot id: A0A8J8Y5F0
uniprot id: G7PUX6
names: Similarity
messages: Belongs to the TMEM106 family.

9541:DYNLT5
gene id: 9541:DYNLT5
uniprot id: A0A2K5VPL7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9541:APLP1
gene id: 9541:APLP1
uniprot id: A0A2K5WNL8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:LOC102115969
gene id: 9541:LOC102115969
uniprot id: A0A8J8YAJ5
uniprot id: G7NXM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9541:MARS1
gene id: 9541:MARS1
uniprot id: A0A2K5UET5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:IP6K2
gene id: 9541:IP6K2
uniprot id: A0A2K5UWS7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9541:LOC102120369
gene id: 9541:LOC102120369
uniprot id: A0A2K5V493
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102136862
gene id: 9541:LOC102136862
uniprot id: A4L264
uniprot id: S6E293
names: Similarity
messages: Belongs to the MHC class II family.

9541:MPDU1
gene id: 9541:MPDU1
uniprot id: G7PTI3
names: Subcellular Location Annotation
messages: Membrane

9541:CDH4
gene id: 9541:CDH4
uniprot id: A0A2K5VYM4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:GPR3
gene id: 9541:GPR3
uniprot id: A0A2K5UKC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:VAMP8
gene id: 9541:VAMP8
uniprot id: A0A2K5WGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9541:HSPA13
gene id: 9541:HSPA13
uniprot id: A0A8J8XTB4
uniprot id: G7P242
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

9541:ATG16L1
gene id: 9541:ATG16L1
uniprot id: A0A2K5TQA7
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9541:CLDN2
gene id: 9541:CLDN2
uniprot id: A0A8J8YF99
uniprot id: G7Q3E1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:TXNL4A
gene id: 9541:TXNL4A
uniprot id: A0A2K5U5Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9541:SNX32
gene id: 9541:SNX32
uniprot id: A0A2K5WB75
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9541:ESCO1
gene id: 9541:ESCO1
uniprot id: A0A2K5W278
uniprot id: A0A7N9CRD6
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC123566751
gene id: 9541:LOC123566751
uniprot id: A0A2K5TUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9541:G2E3
gene id: 9541:G2E3
uniprot id: Q4R9C4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
messages: Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity.
messages: nucleolus

9541:DEFB118
gene id: 9541:DEFB118
uniprot id: A0A2K5WHK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:FAM166C
gene id: 9541:FAM166C
uniprot id: A0A2K5TMN1
names: Similarity
messages: Belongs to the CIMIP2 family.

9541:PROX1
gene id: 9541:PROX1
uniprot id: A0A2K5VZ70
names: Subcellular Location Annotation
messages: Nucleus

9541:MSRB3
gene id: 9541:MSRB3
uniprot id: A0A2K5UWU1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9541:STX11
gene id: 9541:STX11
uniprot id: A0A8J8YD53
uniprot id: G7P509
names: Similarity
messages: Belongs to the syntaxin family.

9541:OSBPL6
gene id: 9541:OSBPL6
uniprot id: A0A2K5WF67
uniprot id: A0A2K5WF76
uniprot id: A0A2K5WFF0
uniprot id: A0A8J8YEW8
uniprot id: G7PKX7
names: Similarity
messages: Belongs to the OSBP family.

9541:LOC101867486
gene id: 9541:LOC101867486
uniprot id: A0A8J8YLZ9
uniprot id: G7P4F8
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9541:ERBB4
gene id: 9541:ERBB4
uniprot id: A0A2K5W0D3
uniprot id: A0A2K5W0D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9541:CXCL11
gene id: 9541:CXCL11
uniprot id: A0A8J8XWC3
uniprot id: G7P556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:PCMTD1
gene id: 9541:PCMTD1
uniprot id: A0A2K5UCP9
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9541:COPA
gene id: 9541:COPA
uniprot id: A0A2K5UZ52
uniprot id: G7NWD0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9541:MST1
gene id: 9541:MST1
uniprot id: A0A2K5WCZ4
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SEM1
gene id: 9541:SEM1
uniprot id: A0A8J8XZN6
uniprot id: G7P1B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

9541:NDRG4
gene id: 9541:NDRG4
uniprot id: A0A2K5VQV9
uniprot id: A0A2K5VQZ6
names: Similarity
messages: Belongs to the NDRG family.

9541:SLC7A9
gene id: 9541:SLC7A9
uniprot id: A0A8J8YMC4
uniprot id: G7PX58
names: Subcellular Location Annotation
messages: Membrane

9541:INPP4B
gene id: 9541:INPP4B
uniprot id: A0A2K5UC87
uniprot id: A0A2K5UC97
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9541:KRT36
gene id: 9541:KRT36
uniprot id: A0A2K5WK83
names: Similarity
messages: Belongs to the intermediate filament family.

9541:HJV
gene id: 9541:HJV
uniprot id: A0A2K5TJX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9541:PGAP3
gene id: 9541:PGAP3
uniprot id: A0A7N9CNG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Membrane

9541:VAMP7
gene id: 9541:VAMP7
uniprot id: A0A7N9D129
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9541:MTCP1
gene id: 9541:MTCP1
uniprot id: A0A2K5U7K1
names: Similarity
messages: Belongs to the TCL1 family.

9541:MEOX2
gene id: 9541:MEOX2
uniprot id: A0A8J8Y4L1
uniprot id: G7P192
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102137032
gene id: 9541:LOC102137032
uniprot id: A0A2K5UJ02
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9541:DEFB113
gene id: 9541:DEFB113
uniprot id: A0A2K5U0I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:CDH10
gene id: 9541:CDH10
uniprot id: A0A8J8XCU9
uniprot id: G7P7A7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:RBP4
gene id: 9541:RBP4
uniprot id: A0A2K5W172
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Secreted

9541:DCT
gene id: 9541:DCT
uniprot id: A0A2K5VPR3
uniprot id: A0A8J8XD96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9541:RO60
gene id: 9541:RO60
uniprot id: A0A8J8YFB4
uniprot id: G7NXD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9541:OSBPL2
gene id: 9541:OSBPL2
uniprot id: A0A2K5UP32
names: Similarity
messages: Belongs to the OSBP family.

9541:APOC1
gene id: 9541:APOC1
uniprot id: P18657
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.
messages: Belongs to the apolipoprotein C1 family.
messages: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
messages: Secreted

9541:TIPIN
gene id: 9541:TIPIN
uniprot id: A0A2K5UYX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9541:B3GNT7
gene id: 9541:B3GNT7
uniprot id: A0A2K5V5Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:CCM2
gene id: 9541:CCM2
uniprot id: A0A2K5TWM1
uniprot id: A0A2K5TWQ3
names: Similarity
messages: Belongs to the CCM2 family.

9541:CAPN1
gene id: 9541:CAPN1
uniprot id: Q9GLG2
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by micromolar concentrations of calcium and inhibited by calpastatin.
messages: Belongs to the peptidase C2 family.
messages: Binds 4 Ca(2+) ions.
messages: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1. Cleaves and activates caspase-7 (CASP7).
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
messages: Ubiquitous.
messages: Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms (By similarity).

9541:PPARG
gene id: 9541:PPARG
uniprot id: A0A2K5WFM9
uniprot id: A0A2K5WFQ0
uniprot id: A0A8J8YEQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9541:SLC66A3
gene id: 9541:SLC66A3
uniprot id: A0A2K5WPR6
uniprot id: A0A2K5WPV1
names: Subcellular Location Annotation
messages: Membrane

9541:FPR1
gene id: 9541:FPR1
uniprot id: G7PYI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9541:RAD51
gene id: 9541:RAD51
uniprot id: A0A2K5VN96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9541:MFSD10
gene id: 9541:MFSD10
uniprot id: A0A2K5WMB8
names: Subcellular Location Annotation
messages: Membrane

9541:DOCK1
gene id: 9541:DOCK1
uniprot id: A0A2K5WQR8
names: Similarity
messages: Belongs to the DOCK family.

9541:TMEM168
gene id: 9541:TMEM168
uniprot id: A0A2K5UIL0
uniprot id: A0A8J8XBZ6
uniprot id: G7P2H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane
messages: Nucleus membrane

9541:USP15
gene id: 9541:USP15
uniprot id: A0A2K5TK24
uniprot id: A0A2K5TK29
uniprot id: A0A8J8YA73
uniprot id: G7PIX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9541:ACTR8
gene id: 9541:ACTR8
uniprot id: A0A8J8YT00
uniprot id: G7NZU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9541:XPO1
gene id: 9541:XPO1
uniprot id: A0A2K5WNY6
uniprot id: A0A7N9CMG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9541:GCHFR
gene id: 9541:GCHFR
uniprot id: A0A8J8YET9
uniprot id: G7PAX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9541:LOC102120481
gene id: 9541:LOC102120481
uniprot id: A0A2K5V9N2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.
messages: Secreted

9541:SLC30A7
gene id: 9541:SLC30A7
uniprot id: A0A2K5VGN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9541:LRRC51
gene id: 9541:LRRC51
uniprot id: A0A2K5WTJ8
uniprot id: A0A8J8XIN6
names: Subcellular Location Annotation
messages: Cytoplasm

9541:HSPH1
gene id: 9541:HSPH1
uniprot id: A0A2K5UIW1
uniprot id: A0A7N9CYX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9541:PSMF1
gene id: 9541:PSMF1
uniprot id: A0A7N9CTK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9541:CLDN14
gene id: 9541:CLDN14
uniprot id: A0A8J8XGB7
uniprot id: G7P110
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:C2H3orf70
gene id: 9541:C2H3orf70
uniprot id: A0A7N9D6P6
names: Similarity
messages: Belongs to the UPF0524 family.

9541:PMM2
gene id: 9541:PMM2
uniprot id: A0A7N9D5M6
uniprot id: Q60HD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9541:MAP3K7
gene id: 9541:MAP3K7
uniprot id: A0A2K5WPW4
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

9541:SMG6
gene id: 9541:SMG6
uniprot id: A0A2K5W9N0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.
messages: Plays a role in nonsense-mediated mRNA decay.
messages: The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.
messages: cytosol
messages: nucleolus
messages: telomere

9541:LOC102117721
gene id: 9541:LOC102117721
uniprot id: G7P2L6
uniprot id: G7P2P0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:CCL23
gene id: 9541:CCL23
uniprot id: A0A2K5WBA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:NKX6-3
gene id: 9541:NKX6-3
uniprot id: A0A2K5X268
names: Subcellular Location Annotation
messages: Nucleus

9541:RPS23
gene id: 9541:RPS23
uniprot id: A0A2K5WRR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Rough endoplasmic reticulum

9541:HNRNPF
gene id: 9541:HNRNPF
uniprot id: A0A8J8YQZ5
uniprot id: G7PER4
uniprot id: Q60HC3
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).
messages: Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1 (By similarity).
messages: Sumoylated.
messages: The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.
messages: nucleoplasm

9541:LOC102124658
gene id: 9541:LOC102124658
uniprot id: I7GPH0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9541:CASTOR1
gene id: 9541:CASTOR1
uniprot id: A0A2K5TZC7
names: Similarity
messages: Belongs to the GATS family.

9541:PHKA2
gene id: 9541:PHKA2
uniprot id: A0A2K5VLC1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9541:PDIK1L
gene id: 9541:PDIK1L
uniprot id: A0A2K5VL47
uniprot id: A0A7N9CFE3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:TBX6
gene id: 9541:TBX6
uniprot id: A0A2K5U947
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:ARHGDIB
gene id: 9541:ARHGDIB
uniprot id: A0A2K5X5E9
names: Similarity
messages: Belongs to the Rho GDI family.

9541:LOC102129682
gene id: 9541:LOC102129682
uniprot id: Q4R4K6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
messages: Component of the small ribosomal subunit.
messages: Cytoplasm
messages: Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.
messages: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.
messages: Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.

9541:CHEK1
gene id: 9541:CHEK1
uniprot id: A0A2K5UAE9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9541:ARSL
gene id: 9541:ARSL
uniprot id: A0A2K5WPD0
uniprot id: A0A2K5WPF2
names: Similarity
messages: Belongs to the sulfatase family.

9541:PDYN
gene id: 9541:PDYN
uniprot id: A0A7N9I981
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
messages: Secreted

9541:GPC6
gene id: 9541:GPC6
uniprot id: A0A2K5VNV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9541:SNX2
gene id: 9541:SNX2
uniprot id: A0A2K5UNF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9541:ADD3
gene id: 9541:ADD3
uniprot id: A0A2K5UVU3
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9541:TNFRSF9
gene id: 9541:TNFRSF9
uniprot id: A0A8J8XDS9
uniprot id: A9YYE7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PLP1
gene id: 9541:PLP1
uniprot id: I7G2D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9541:CLDN19
gene id: 9541:CLDN19
uniprot id: A0A2K5UHK0
uniprot id: A0A7N9C8X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:PRICKLE1
gene id: 9541:PRICKLE1
uniprot id: A0A2K5UIZ2
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9541:ITPA
gene id: 9541:ITPA
uniprot id: A0A2K5X2C2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9541:NPRL2
gene id: 9541:NPRL2
uniprot id: A0A8J8XVQ8
uniprot id: G7NXS3
names: Similarity
messages: Belongs to the NPR2 family.

9541:KEG98 p09
gene id: 9541:KEG98_p09
uniprot id: C3W4Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9541:KIF17
gene id: 9541:KIF17
uniprot id: A0A2K5VJL7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:BMT2
gene id: 9541:BMT2
uniprot id: A0A2K5VYL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9541:GPC4
gene id: 9541:GPC4
uniprot id: A0A2K5TSH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9541:TIGD6
gene id: 9541:TIGD6
uniprot id: A0A2K5ULI2
names: Subcellular Location Annotation
messages: Nucleus

9541:KPNA6
gene id: 9541:KPNA6
uniprot id: A0A2K5X9F2
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9541:MARVELD2
gene id: 9541:MARVELD2
uniprot id: A0A2K5VNG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9541:LOC102133777
gene id: 9541:LOC102133777
uniprot id: A0A8J8XNB8
uniprot id: G7PII2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9541:LOC102123177
gene id: 9541:LOC102123177
uniprot id: A0A2K5V3J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FXYD family.
messages: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
messages: Membrane
messages: Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

9541:DRD2
gene id: 9541:DRD2
uniprot id: A0A2K5VFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9541:THUMPD3
gene id: 9541:THUMPD3
uniprot id: A0A2K5VQ92
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9541:TAF5L
gene id: 9541:TAF5L
uniprot id: A0A2K5U671
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9541:KRR1
gene id: 9541:KRR1
uniprot id: A0A2K5TN33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9541:SLC6A13
gene id: 9541:SLC6A13
uniprot id: A0A2K5TN47
uniprot id: Q2PG55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (By similarity). Can also mediate transport of beta-alanine, taurine and hypotaurine (By similarity).
messages: Membrane

9541:PRPF18
gene id: 9541:PRPF18
uniprot id: A0A2K5X8J0
uniprot id: A0A8J8XTV6
uniprot id: G7PEE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9541:IFT46
gene id: 9541:IFT46
uniprot id: A0A2K5VPG7
uniprot id: G8F447
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9541:CPLX4
gene id: 9541:CPLX4
uniprot id: A0A2K5X485
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9541:CDC6
gene id: 9541:CDC6
uniprot id: A0A2K5VLB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9541:TMEM45A
gene id: 9541:TMEM45A
uniprot id: A0A8J8Y5X3
uniprot id: G7NZP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9541:RPS20
gene id: 9541:RPS20
uniprot id: G7Q2E4
uniprot id: Q4R5D0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Polyubiquitinated by ZNF598 via 'Lys-63'-linked ubiquitin chains when a ribosome has stalled, initiating the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide. Deubiquitinated by OTUD3 and USP21, antagonizing ZNF598 activity.
messages: Ufmylated by UFL1.

9541:PLCG2
gene id: 9541:PLCG2
uniprot id: A0A2K5W153
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9541:LOC102140245
gene id: 9541:LOC102140245
uniprot id: A0A2K5W1M2
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9541:PROM1
gene id: 9541:PROM1
uniprot id: A0A2K5VIM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9541:KCNA1
gene id: 9541:KCNA1
uniprot id: A0A2K5UKT9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:SH3RF2
gene id: 9541:SH3RF2
uniprot id: A0A2K5VZW3
names: Similarity
messages: Belongs to the SH3RF family.

9541:ATP13A3
gene id: 9541:ATP13A3
uniprot id: Q95JN5
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol.
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Early endosome membrane
messages: Late endosome membrane
messages: Recycling endosome membrane

9541:TLN1
gene id: 9541:TLN1
uniprot id: A0A2K5VGA4
uniprot id: A0A8J8XB34
uniprot id: G7PRZ9
names: Subcellular Location Annotation
messages: cytoskeleton

9541:TMEM39B
gene id: 9541:TMEM39B
uniprot id: A0A2K5TPN6
uniprot id: A0A2K5TPQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9541:LSM6
gene id: 9541:LSM6
uniprot id: A0A2K5V611
uniprot id: G8F3L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9541:MRPS16
gene id: 9541:MRPS16
uniprot id: G7PF15
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9541:BABAM2
gene id: 9541:BABAM2
uniprot id: A0A7N9CLQ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9541:IL1RN
gene id: 9541:IL1RN
uniprot id: A0A7N9DF26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9541:UBE4B
gene id: 9541:UBE4B
uniprot id: A0A2K5W1H3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

9541:C12H2orf88
gene id: 9541:C12H2orf88
uniprot id: A0A7N9CPM8
uniprot id: A0A8J8XQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9541:SYBU
gene id: 9541:SYBU
uniprot id: A0A2K5WIU6
uniprot id: A0A2K5WIV9
names: Subcellular Location Annotation
messages: Membrane

9541:ACVR2B
gene id: 9541:ACVR2B
uniprot id: A0A2K5WUB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:MMP19
gene id: 9541:MMP19
uniprot id: A0A2K5U112
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9541:DHRS7B
gene id: 9541:DHRS7B
uniprot id: A0A2K5UL93
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:GNRHR
gene id: 9541:GNRHR
uniprot id: A0A2K5WH82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LOC102134028
gene id: 9541:LOC102134028
uniprot id: A0A7N9CRH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9541:MTX2
gene id: 9541:MTX2
uniprot id: A0A8J8Y183
uniprot id: G7PKW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9541:ATF7IP2
gene id: 9541:ATF7IP2
uniprot id: A0A2K5UZ39
uniprot id: A0A2K5UZ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9541:HSA3
gene id: 9541:HSA3
uniprot id: A0A8J8XZM3
uniprot id: G7PIE1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Odorant receptor.

9541:E2F2
gene id: 9541:E2F2
uniprot id: A0A2K5V0F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9541:STMN1
gene id: 9541:STMN1
uniprot id: A0A805RLD7
uniprot id: Q25QD1
uniprot id: Q4R712
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the stathmin family.
messages: Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST (By similarity).
messages: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
messages: Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity (By similarity).
messages: cytoskeleton

9541:SH2D1A
gene id: 9541:SH2D1A
uniprot id: A0A2K5U0G4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9541:GADD45B
gene id: 9541:GADD45B
uniprot id: A0A8J8Y6A9
uniprot id: G7PYD1
names: Similarity
messages: Belongs to the GADD45 family.

9541:NLN
gene id: 9541:NLN
uniprot id: A0A2K5UXD0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9541:GPR6
gene id: 9541:GPR6
uniprot id: G8F545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:FLAD1
gene id: 9541:FLAD1
uniprot id: A0A8J8XYE5
uniprot id: G7NUJ8
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9541:LOC102128952
gene id: 9541:LOC102128952
uniprot id: A0A2K5VMY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9541:MINDY3
gene id: 9541:MINDY3
uniprot id: A0A7N9CXL7
uniprot id: G7PEF7
uniprot id: Q4R528
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
messages: Interacts with COPS5.
messages: Nucleus

9541:AP1S2
gene id: 9541:AP1S2
uniprot id: A0A2K5TTY7
uniprot id: A0A2K5TU05
uniprot id: A0A7N9DB11
uniprot id: A0A8J8XS11
uniprot id: G7Q2A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9541:ZFX
gene id: 9541:ZFX
uniprot id: A0A2K5UW34
uniprot id: A0A2K5UW70
names: Subcellular Location Annotation
messages: Nucleus

9541:THBS1
gene id: 9541:THBS1
uniprot id: A0A2K5V619
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:POMGNT1
gene id: 9541:POMGNT1
uniprot id: A0A2K5TKS6
uniprot id: A0A7N9CN01
uniprot id: G7NV04
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The cofactor is mostly bound to the substrate.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9541:FGB
gene id: 9541:FGB
uniprot id: A0A8J8XQ55
uniprot id: G7P6F7
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9541:TMEM256
gene id: 9541:TMEM256
uniprot id: A0A8J8YPW7
uniprot id: G7PTH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9541:GPR155
gene id: 9541:GPR155
uniprot id: A0A2K5TM64
names: Subcellular Location Annotation
messages: Membrane

9541:HDX
gene id: 9541:HDX
uniprot id: A0A2K5W8Y0
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102138546
gene id: 9541:LOC102138546
uniprot id: A0A8J8YQA3
uniprot id: G7NTQ1
names: Similarity
messages: Belongs to the arrestin family.

9541:CDKAL1
gene id: 9541:CDKAL1
uniprot id: A0A2K5V9T0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9541:SLC24A5
gene id: 9541:SLC24A5
uniprot id: A0A8J8Y5C6
uniprot id: G7PV94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9541:CACNA2D1
gene id: 9541:CACNA2D1
uniprot id: A0A2K5VRT5
uniprot id: A0A2K5VRW1
uniprot id: A0A7N9ICS8
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9541:NDST2
gene id: 9541:NDST2
uniprot id: A0A2K5X0Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9541:VAMP4
gene id: 9541:VAMP4
uniprot id: A0A8J8XDD2
uniprot id: G7NVH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9541:DGKE
gene id: 9541:DGKE
uniprot id: A0A7N9CLX3
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9541:LOC102129860
gene id: 9541:LOC102129860
uniprot id: A0A2K5UUY6
names: Similarity
messages: Belongs to the CEMIP family.

9541:NIPSNAP3A
gene id: 9541:NIPSNAP3A
uniprot id: A0A8J8Y936
uniprot id: G7PRS1
names: Similarity
messages: Belongs to the NipSnap family.

9541:CTNNA2
gene id: 9541:CTNNA2
uniprot id: A0A2K5WE01
uniprot id: A0A8J8XE84
uniprot id: G7PML1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9541:FOXA3
gene id: 9541:FOXA3
uniprot id: A0A7N9CHB5
names: Subcellular Location Annotation
messages: Nucleus

9541:TREX1
gene id: 9541:TREX1
uniprot id: A0A7N9D4U6
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9541:ANKH
gene id: 9541:ANKH
uniprot id: A0A2K5WPU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9541:BLCAP
gene id: 9541:BLCAP
uniprot id: A0A7N9CIA7
uniprot id: A0A8J8Y731
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

9541:TMEM165
gene id: 9541:TMEM165
uniprot id: A0A2K5WGW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

9541:GNGT1
gene id: 9541:GNGT1
uniprot id: A0A2K5TRU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:ENO1
gene id: 9541:ENO1
uniprot id: A0A2K5VXB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9541:CD4
gene id: 9541:CD4
uniprot id: A0A8J8YDH1
uniprot id: G7PJN3
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs.

9541:CCS
gene id: 9541:CCS
uniprot id: A0A2K5X1C8
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9541:GNG3
gene id: 9541:GNG3
uniprot id: A0A8J8XIX8
uniprot id: I7GMQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:OSBPL8
gene id: 9541:OSBPL8
uniprot id: A0A2K5TKF4
uniprot id: A0A2K5TKK1
uniprot id: A0A2K5TKK3
uniprot id: A0A8J8XM37
names: Similarity
messages: Belongs to the OSBP family.

9541:PEMT
gene id: 9541:PEMT
uniprot id: A0A2K5WQG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9541:S100A2
gene id: 9541:S100A2
uniprot id: A0A2K5WB64
names: Similarity
messages: Belongs to the S-100 family.

9541:LITAF
gene id: 9541:LITAF
uniprot id: A0A7N9IFP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9541:RLN2
gene id: 9541:RLN2
uniprot id: G7PSF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

9541:MEA1
gene id: 9541:MEA1
uniprot id: A0A8J8Y7N4
uniprot id: G7P3Y9
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

9541:TM9SF2
gene id: 9541:TM9SF2
uniprot id: A0A2K5VMH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9541:C9H10orf53
gene id: 9541:C9H10orf53
uniprot id: A0A2K5VMA8
names: Similarity
messages: Belongs to the UPF0728 family.

9541:PIERCE2
gene id: 9541:PIERCE2
uniprot id: A0A2K5VEM4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9541:TMEM186
gene id: 9541:TMEM186
uniprot id: A0A2K5UP18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9541:GPR50
gene id: 9541:GPR50
uniprot id: A0A2K5WGA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PAPOLA
gene id: 9541:PAPOLA
uniprot id: A0A2K5TXG9
uniprot id: A0A2K5TXH2
uniprot id: A0A2K5TXL7
uniprot id: A0A2K5TXP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

9541:TRIM17
gene id: 9541:TRIM17
uniprot id: A0A2K5TV96
uniprot id: A0A7N9D4A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9541:MMP16
gene id: 9541:MMP16
uniprot id: A0A8J8YC73
uniprot id: G7PC63
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9541:POFUT1
gene id: 9541:POFUT1
uniprot id: A0A2K5WTE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 65 family.
messages: Endoplasmic reticulum

9541:DZIP1
gene id: 9541:DZIP1
uniprot id: A0A2K5UR24
uniprot id: A0A2K5UR64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

9541:MGAT5
gene id: 9541:MGAT5
uniprot id: A0A8J8XC29
uniprot id: G7PN39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9541:GPD1L
gene id: 9541:GPD1L
uniprot id: A0A2K5V4P5
uniprot id: A0A8J8XJW7
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9541:ARHGEF9
gene id: 9541:ARHGEF9
uniprot id: A0A2K5U8X3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
messages: Cytoplasm
messages: Interacts with GPHN.
messages: Postsynaptic density

9541:LOC102144671
gene id: 9541:LOC102144671
uniprot id: G7PKU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cytoplasm

9541:SLC2A4
gene id: 9541:SLC2A4
uniprot id: A0A2K5URC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9541:LOC102117210
gene id: 9541:LOC102117210
uniprot id: A0A2K5U3K9
uniprot id: A0A2K5U3L6
uniprot id: A0A2K5U3S4
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102138406
gene id: 9541:LOC102138406
uniprot id: G7P2Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:TRMT2B
gene id: 9541:TRMT2B
uniprot id: A0A2K5VUK1
uniprot id: A0A2K5VUK7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102135688
gene id: 9541:LOC102135688
uniprot id: A0A2K5UM27
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9541:PRKD3
gene id: 9541:PRKD3
uniprot id: A0A2K5W5R6
uniprot id: A0A8J8Y978
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9541:CCNT1
gene id: 9541:CCNT1
uniprot id: A0A2K5W0G8
names: Similarity
messages: Belongs to the cyclin family.

9541:LOC102127229
gene id: 9541:LOC102127229
uniprot id: P67992
uniprot id: Q25CR9
names: Disease Annotation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prion family.
messages: Cell membrane
messages: Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.
messages: Golgi apparatus
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
messages: Membrane
messages: Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement. Interacts with KIAA1191.
messages: PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
messages: The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization.

9541:ITGB6
gene id: 9541:ITGB6
uniprot id: A0A2K5TZ36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9541:SCAMP4
gene id: 9541:SCAMP4
uniprot id: A0A2K5VSR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9541:LOC102126703
gene id: 9541:LOC102126703
uniprot id: A0A2K5TPY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9541:ST7L
gene id: 9541:ST7L
uniprot id: A0A2K5U4M1
uniprot id: A0A7N9IG89
uniprot id: G7NW64
uniprot id: Q4R346
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9541:PSMB3
gene id: 9541:PSMB3
uniprot id: A0A8J8XRQ2
uniprot id: G7PUK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9541:RBPMS2
gene id: 9541:RBPMS2
uniprot id: A0A2K5VT66
names: Subcellular Location Annotation
messages: Cytoplasm

9541:NDUFS3
gene id: 9541:NDUFS3
uniprot id: A0A8J8XXC2
uniprot id: G7PQ90
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

9541:PBX1
gene id: 9541:PBX1
uniprot id: A0A2K5TYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9541:ADIPOR1
gene id: 9541:ADIPOR1
uniprot id: A0A2K5UDE4
uniprot id: G8F668
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:VAMP5
gene id: 9541:VAMP5
uniprot id: A0A2K5UEI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9541:MARCHF4
gene id: 9541:MARCHF4
uniprot id: A0A8J8XS02
uniprot id: G7PLD9
names: Subcellular Location Annotation
messages: Membrane

9541:BMP5
gene id: 9541:BMP5
uniprot id: A0A2K5UUA8
names: Similarity
messages: Belongs to the TGF-beta family.

9541:TMEM115
gene id: 9541:TMEM115
uniprot id: A0A8J8XPV1
uniprot id: G7NZZ0
names: Subcellular Location Annotation
messages: Membrane

9541:PSMC2
gene id: 9541:PSMC2
uniprot id: Q4R4R0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components. Interacts with NDC80/HEC; this interaction is detected only during M phase. Interacts and SQSTM1. Interacts with PAAF1. Directly interacts with TRIM5.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm
messages: Monoubiquitinated by RNF181.
messages: Nucleus
messages: Phosphorylated. Dephosphorylated by UBLCP1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly.

9541:SLC25A12
gene id: 9541:SLC25A12
uniprot id: A0A2K5W4N3
uniprot id: A0A2K5W4N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9541:PRKACB
gene id: 9541:PRKACB
uniprot id: A0A2K5VK60
uniprot id: A0A2K5VKF1
uniprot id: A0A2K5VKF2
uniprot id: A0A2K5VKH9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9541:SLC6A17
gene id: 9541:SLC6A17
uniprot id: A0A2K5VNV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9541:VIPAS39
gene id: 9541:VIPAS39
uniprot id: G7PB33
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9541:OTUD7B
gene id: 9541:OTUD7B
uniprot id: A0A2K5TTA1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:UBE2D4
gene id: 9541:UBE2D4
uniprot id: A0A7N9D203
uniprot id: A0A7N9D2F9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:BTF3L4
gene id: 9541:BTF3L4
uniprot id: A0A8J8XYY3
uniprot id: G7NVN7
names: Similarity
messages: Belongs to the NAC-beta family.

9541:LOC102122033
gene id: 9541:LOC102122033
uniprot id: A0A2K5W9H0
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9541:KCNC2
gene id: 9541:KCNC2
uniprot id: A0A2K5V4K9
uniprot id: A0A2K5V4M9
uniprot id: A0A2K5V4V6
uniprot id: A0A2K5V4W3
uniprot id: A0A7N9CRZ4
uniprot id: A0A7N9IBK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:PDCD5
gene id: 9541:PDCD5
uniprot id: A0A2K5VM63
names: Similarity
messages: Belongs to the PDCD5 family.

9541:ACE2
gene id: 9541:ACE2
uniprot id: A0A2K5X283
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9541:CAPN3
gene id: 9541:CAPN3
uniprot id: A0A2K5UIG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9541:MFSD5
gene id: 9541:MFSD5
uniprot id: A0A2K5X0Q1
uniprot id: G7PHU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

9541:SMIM14
gene id: 9541:SMIM14
uniprot id: A0A8J8XAY3
uniprot id: G7P5F8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9541:SLC35F4
gene id: 9541:SLC35F4
uniprot id: A0A2K5TUD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9541:PHF20L1
gene id: 9541:PHF20L1
uniprot id: A0A2K5W4N7
names: Subcellular Location Annotation
messages: Nucleus

9541:ALDH3A1
gene id: 9541:ALDH3A1
uniprot id: A0A2K5VDK6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:SMPD2
gene id: 9541:SMPD2
uniprot id: A0A8J8XLY1
uniprot id: G7P3P3
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9541:KCND3
gene id: 9541:KCND3
uniprot id: A0A2K5TXA6
uniprot id: A0A8J8XCK3
uniprot id: G7NW61
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9541:KEG98 p07
gene id: 9541:KEG98_p07
uniprot id: C3W4Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

9541:EFHB
gene id: 9541:EFHB
uniprot id: A0A2K5UL59
names: Subcellular Location Annotation
messages: cilium axoneme

9541:INHBA
gene id: 9541:INHBA
uniprot id: A0A2K5WK99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9541:KDM5C
gene id: 9541:KDM5C
uniprot id: A0A2K5X0F4
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9541:S100A10
gene id: 9541:S100A10
uniprot id: A0A2K5VQE4
uniprot id: G7NTU2
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9541:HCRTR2
gene id: 9541:HCRTR2
uniprot id: A0A2K5WVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:GMFB
gene id: 9541:GMFB
uniprot id: A0A2K5W225
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9541:IL17RB
gene id: 9541:IL17RB
uniprot id: A0A2K5TUM4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:LOC102117012
gene id: 9541:LOC102117012
uniprot id: A0A7N9D238
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:CPEB4
gene id: 9541:CPEB4
uniprot id: A0A2K5W828
uniprot id: A0A2K5W834
uniprot id: A0A8J8XCI2
uniprot id: G7P6X8
names: Similarity
messages: Belongs to the RRM CPEB family.

9541:KRT18
gene id: 9541:KRT18
uniprot id: A0A2K5VDB4
names: Similarity
messages: Belongs to the intermediate filament family.

9541:LOC102144039
gene id: 9541:LOC102144039
uniprot id: A0A8J8XSB1
uniprot id: A4L283
names: Similarity
messages: Belongs to the MHC class II family.

9541:GATA1
gene id: 9541:GATA1
uniprot id: A0A2K5UYX7
names: Subcellular Location Annotation
messages: Nucleus

9541:THAP10
gene id: 9541:THAP10
uniprot id: A0A2K5VBC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9541:GRK6
gene id: 9541:GRK6
uniprot id: A0A2K5WTN2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9541:LOC102116103
gene id: 9541:LOC102116103
uniprot id: A0A2K5V4B5
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:SRPRB
gene id: 9541:SRPRB
uniprot id: I7GK96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:UPP1
gene id: 9541:UPP1
uniprot id: A0A2K5W8D7
uniprot id: A0A8J8XDU8
uniprot id: G7P1S6
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9541:KIF2A
gene id: 9541:KIF2A
uniprot id: A0A2K5U740
uniprot id: A0A2K5U772
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:PGD
gene id: 9541:PGD
uniprot id: A0A2K5WBE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9541:LRRFIP2
gene id: 9541:LRRFIP2
uniprot id: A0A2K5V262
uniprot id: A0A8J8Y1V3
uniprot id: G7NYL4
names: Similarity
messages: Belongs to the LRRFIP family.

9541:LOC102137734
gene id: 9541:LOC102137734
uniprot id: A0A2K5V565
uniprot id: A0A8J8YNK8
uniprot id: G7Q1B2
names: Subcellular Location Annotation
messages: Membrane

9541:CDK20
gene id: 9541:CDK20
uniprot id: A0A2K5VFY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: cilium

9541:CD79B
gene id: 9541:CD79B
uniprot id: G8F5R6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:TENT5D
gene id: 9541:TENT5D
uniprot id: A0A7N9DC55
uniprot id: G8F374
names: Similarity
messages: Belongs to the TENT family.

9541:TBP
gene id: 9541:TBP
uniprot id: G7P4B0
uniprot id: Q4R4F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBP family.
messages: Binds DNA as monomer. Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Association of TBP to form either TFIID or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A, TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with UTF1. Interacts with BRF2; this interaction promotes recruitment of BRF2 to TATA box-containing promoters. Interacts with UBTF. Interacts with GPBP1. Interacts with CITED2. Interacts with ATF7IP. Interacts with LLPH. Interacts with HSF1 (via transactivation domain). Interacts with GTF2B (via C-terminus); this interaction with promoter-bound TBP guides RNA polymerase II into the pre-initiation complex (PIC). Interacts with PAX5 (By similarity). Interacts with MSX1; the interaction may inhibit MSX1 autoinactivation (By similarity).
messages: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
messages: Nucleus

9541:TUBD1
gene id: 9541:TUBD1
uniprot id: A0A2K5VTU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9541:ACADS
gene id: 9541:ACADS
uniprot id: A0A2K5U8K3
uniprot id: A0A7N9DAV7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9541:VANGL2
gene id: 9541:VANGL2
uniprot id: A0A2K5TQ83
uniprot id: A0A8J8YP28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9541:RPS27
gene id: 9541:RPS27
uniprot id: A0A2K5U4U7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9541:SHTN1
gene id: 9541:SHTN1
uniprot id: A0A2K5W164
uniprot id: A0A2K5W1E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: Perikaryon
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9541:KPNA3
gene id: 9541:KPNA3
uniprot id: I7GIR2
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9541:LETMD1
gene id: 9541:LETMD1
uniprot id: A0A2K5VAU8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

9541:CALB2
gene id: 9541:CALB2
uniprot id: A0A2K5VV88
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9541:GPI
gene id: 9541:GPI
uniprot id: Q4R591
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Cytoplasm
messages: Homodimer; in the catalytically active form. Monomer in the secreted form.
messages: ISGylated.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).
messages: Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.
messages: Secreted

9541:TPRG1
gene id: 9541:TPRG1
uniprot id: A0A7N9CF06
names: Similarity
messages: Belongs to the TPRG1 family.

9541:CCNE2
gene id: 9541:CCNE2
uniprot id: A0A2K5TJW9
names: Similarity
messages: Belongs to the cyclin family.

9541:AMPD1
gene id: 9541:AMPD1
uniprot id: A0A2K5WKN4
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9541:ARL11
gene id: 9541:ARL11
uniprot id: G7PVF1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9541:EXOSC9
gene id: 9541:EXOSC9
uniprot id: A0A2K5TR67
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SLC35E1
gene id: 9541:SLC35E1
uniprot id: G7PZQ9
names: Subcellular Location Annotation
messages: Membrane

9541:EEF1AKMT1
gene id: 9541:EEF1AKMT1
uniprot id: A0A2K5VXZ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9541:ALAS2
gene id: 9541:ALAS2
uniprot id: A0A2K5WA41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9541:CHRDL1
gene id: 9541:CHRDL1
uniprot id: A0A2K5X1H9
names: Subcellular Location Annotation
messages: Secreted

9541:TDO2
gene id: 9541:TDO2
uniprot id: A0A8J8YL40
uniprot id: G7P6G7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102138187
gene id: 9541:LOC102138187
uniprot id: A0A2K5TQN6
uniprot id: A0A2K5TQP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9541:ACVR1
gene id: 9541:ACVR1
uniprot id: A0A8J8XB86
uniprot id: G7PKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:NCBP2L
gene id: 9541:NCBP2L
uniprot id: G7Q3F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9541:MCM8
gene id: 9541:MCM8
uniprot id: A0A2K5VML5
uniprot id: A0A2K5VMP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9541:PTEN
gene id: 9541:PTEN
uniprot id: A0A2K5WAG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
messages: Belongs to the PTEN phosphatase protein family.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

9541:TMTC1
gene id: 9541:TMTC1
uniprot id: A0A2K5V7C9
uniprot id: A0A2K5V7E7
uniprot id: A0A7N9IGR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9541:LOC107129805
gene id: 9541:LOC107129805
uniprot id: A0A7N9IBE1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9541:CACHD1
gene id: 9541:CACHD1
uniprot id: A0A2K5WIQ0
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9541:DOCK7
gene id: 9541:DOCK7
uniprot id: A0A2K5V5M7
uniprot id: A0A2K5V671
names: Similarity
messages: Belongs to the DOCK family.

9541:LOC101865522
gene id: 9541:LOC101865522
uniprot id: A0A2K5UZZ1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9541:PIPOX
gene id: 9541:PIPOX
uniprot id: A0A2K5UKU2
uniprot id: A0A7N9CUM7
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9541:RFC4
gene id: 9541:RFC4
uniprot id: A0A2K5UPQ0
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9541:IFNK
gene id: 9541:IFNK
uniprot id: G7PS65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9541:ILK
gene id: 9541:ILK
uniprot id: A0A2K5WGD3
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9541:ABHD3
gene id: 9541:ABHD3
uniprot id: A0A2K5VRR1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9541:DSTN
gene id: 9541:DSTN
uniprot id: A0A2K5U939
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9541:SUPT6H
gene id: 9541:SUPT6H
uniprot id: A0A8J8XF45
uniprot id: G7PTX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9541:LOC102120655
gene id: 9541:LOC102120655
uniprot id: A0A2K5UJS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9541:LOC102120366
gene id: 9541:LOC102120366
uniprot id: A0A2K5UBY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:ZMYM5
gene id: 9541:ZMYM5
uniprot id: Q4R3D6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Functions as a transcriptional regulator.
messages: Interacts (via N-terminal 120 amino acid region) with ETV5 (via C-terminal).
messages: Nucleus

9541:C14H11orf54
gene id: 9541:C14H11orf54
uniprot id: A0A2K5X568
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9541:TIGD4
gene id: 9541:TIGD4
uniprot id: A0A8J8YH83
uniprot id: G7P6F2
uniprot id: Q4R3E3
names: Subcellular Location Annotation
messages: Nucleus

9541:EIF2AK3
gene id: 9541:EIF2AK3
uniprot id: A0A2K5UXF2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9541:COPB1
gene id: 9541:COPB1
uniprot id: A0A8J8XMC7
uniprot id: G7PQN7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9541:HYOU1
gene id: 9541:HYOU1
uniprot id: A0A2K5TVL3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9541:CREBL2
gene id: 9541:CREBL2
uniprot id: A0A2K5WER1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9541:HACL1
gene id: 9541:HACL1
uniprot id: A0A2K5WFK0
names: Similarity
messages: Belongs to the TPP enzyme family.

9541:NR2C2
gene id: 9541:NR2C2
uniprot id: A0A7N9DFG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:L1CAM
gene id: 9541:L1CAM
uniprot id: A0A2K5UR71
uniprot id: A0A2K5URA1
uniprot id: A0A2K5URB5
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9541:GRIK2
gene id: 9541:GRIK2
uniprot id: A0A2K5X6H7
uniprot id: A0A2K5X6J9
uniprot id: A0A2K5X6L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:ETFA
gene id: 9541:ETFA
uniprot id: A0A2K5UHW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9541:P4HA2
gene id: 9541:P4HA2
uniprot id: A0A2K5WZK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9541:TIMM17A
gene id: 9541:TIMM17A
uniprot id: A0A8J8XC83
uniprot id: G7NWE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9541:ARG1
gene id: 9541:ARG1
uniprot id: A0A2K5VUD1
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9541:TRAM2
gene id: 9541:TRAM2
uniprot id: A0A2K5W093
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9541:LOC102136267
gene id: 9541:LOC102136267
uniprot id: Q8SPH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane

9541:FGD4
gene id: 9541:FGD4
uniprot id: A0A2K5UZI2
uniprot id: A0A2K5UZR6
uniprot id: A0A8J8XZT4
uniprot id: G7PHK8
names: Subcellular Location Annotation
messages: cytoskeleton

9541:ATG7
gene id: 9541:ATG7
uniprot id: A0A8J8Y178
uniprot id: G7NYH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

9541:CRBN
gene id: 9541:CRBN
uniprot id: A0A8J8XQ62
uniprot id: G7NYW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9541:AP3S2
gene id: 9541:AP3S2
uniprot id: G7P9F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9541:SNCB
gene id: 9541:SNCB
uniprot id: A0A2K5TQK0
names: Similarity
messages: Belongs to the synuclein family.

9541:PEBP1
gene id: 9541:PEBP1
uniprot id: P48737
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylethanolamine-binding protein family.
messages: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).
messages: Cytoplasm
messages: HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).
messages: Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade (By similarity).

9541:LOC102118592
gene id: 9541:LOC102118592
uniprot id: A0A2K5UWH6
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9541:VEGFC
gene id: 9541:VEGFC
uniprot id: A0A2K5WBI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9541:LOC102133037
gene id: 9541:LOC102133037
uniprot id: Q4R4D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9541:NF2
gene id: 9541:NF2
uniprot id: A0A2K5WBX3
uniprot id: A0A2K5WC34
uniprot id: A0A2K5WC39
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9541:KEG98 p05
gene id: 9541:KEG98_p05
uniprot id: C3W4Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9541:HIBCH
gene id: 9541:HIBCH
uniprot id: A0A2K5VSZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9541:POLR1C
gene id: 9541:POLR1C
uniprot id: A0A2K5WSZ6
uniprot id: A0A7N9DE58
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9541:STEAP2
gene id: 9541:STEAP2
uniprot id: A0A2K5VTN5
uniprot id: A0A8J8YG83
uniprot id: G7P1U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9541:CENPM
gene id: 9541:CENPM
uniprot id: A0A8J8XLD2
uniprot id: G7PFP3
names: Subcellular Location Annotation
messages: Nucleus

9541:SULT1B1
gene id: 9541:SULT1B1
uniprot id: A0A2K5VZW5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:PORCN
gene id: 9541:PORCN
uniprot id: A0A2K5VCC3
uniprot id: A0A2K5VCF0
uniprot id: A0A2K5VCF9
names: Subcellular Location Annotation
messages: Membrane

9541:STARD3
gene id: 9541:STARD3
uniprot id: A0A2K5VBN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9541:FGF7
gene id: 9541:FGF7
uniprot id: A0A7N9CQ66
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:LOC102120735
gene id: 9541:LOC102120735
uniprot id: A0A2K5TMY4
names: Similarity
messages: Belongs to the SSX family.

9541:LOC102119755
gene id: 9541:LOC102119755
uniprot id: A0A7N9D958
names: Similarity
messages: Belongs to the pro/parathymosin family.

9541:LOC102118223
gene id: 9541:LOC102118223
uniprot id: A0A7N9CZJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:GABRA6
gene id: 9541:GABRA6
uniprot id: G7P6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:TIMM21
gene id: 9541:TIMM21
uniprot id: A0A2K5UW47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9541:TTC30A
gene id: 9541:TTC30A
uniprot id: A0A2K5UG69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9541:SLC7A7
gene id: 9541:SLC7A7
uniprot id: A0A7N9CP17
names: Subcellular Location Annotation
messages: Membrane

9541:MMP10
gene id: 9541:MMP10
uniprot id: A0A2K5UY24
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9541:LOC102134311
gene id: 9541:LOC102134311
uniprot id: A0A8J8XRW3
uniprot id: G7PG07
names: Subcellular Location Annotation
messages: Nucleus

9541:AKAP4
gene id: 9541:AKAP4
uniprot id: A0A7N9D580
names: Similarity
messages: Belongs to the AKAP110 family.

9541:SCRN3
gene id: 9541:SCRN3
uniprot id: A0A2K5WDH9
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9541:ME2
gene id: 9541:ME2
uniprot id: A0A2K5VDY8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9541:PRKAA1
gene id: 9541:PRKAA1
uniprot id: A0A2K5TNP6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9541:TRAPPC3
gene id: 9541:TRAPPC3
uniprot id: A0A2K5WEM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9541:METTL6
gene id: 9541:METTL6
uniprot id: A0A2K5X8T9
uniprot id: A0A2K5X8U1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9541:MTF2
gene id: 9541:MTF2
uniprot id: A0A2K5WIX9
uniprot id: I7G9R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9541:DUSP1
gene id: 9541:DUSP1
uniprot id: A0A2K5VJU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9541:SHMT2
gene id: 9541:SHMT2
uniprot id: G7PIU7
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9541:AMOTL1
gene id: 9541:AMOTL1
uniprot id: A0A2K5V4D9
uniprot id: A0A7N9CZ16
uniprot id: A0A7N9DDM7
names: Similarity
messages: Belongs to the angiomotin family.

9541:LOC102114898
gene id: 9541:LOC102114898
uniprot id: A0A2K5UBU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:GLRA1
gene id: 9541:GLRA1
uniprot id: A0A8J8YBP3
uniprot id: G7P8R5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

9541:FABP2
gene id: 9541:FABP2
uniprot id: A0A8J8YM21
uniprot id: G7P666
names: Function
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9541:POLL
gene id: 9541:POLL
uniprot id: A0A8J8Y921
uniprot id: E5FGI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9541:OVOL1
gene id: 9541:OVOL1
uniprot id: A0A7N9IB29
names: Subcellular Location Annotation
messages: Nucleus

9541:CHAC2
gene id: 9541:CHAC2
uniprot id: A0A7N9D068
uniprot id: A0A8J8XXV5
uniprot id: G7PM72
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9541:LOC102124195
gene id: 9541:LOC102124195
uniprot id: A0A2K5X511
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9541:SLC10A3
gene id: 9541:SLC10A3
uniprot id: A0A2K5VBR1
uniprot id: A0A2K5VBV0
uniprot id: A0A8J8XN72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9541:SULT1E1
gene id: 9541:SULT1E1
uniprot id: A0A2K5WSM8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:LOC102117755
gene id: 9541:LOC102117755
uniprot id: A0A7N9CEQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9541:CREB3L4
gene id: 9541:CREB3L4
uniprot id: Q5UEM8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
messages: Endoplasmic reticulum membrane
messages: Nucleus
messages: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).

9541:XPNPEP2
gene id: 9541:XPNPEP2
uniprot id: A0A8J8Y9Q8
uniprot id: G7Q3N2
names: Similarity
messages: Belongs to the peptidase M24B family.

9541:PEX2
gene id: 9541:PEX2
uniprot id: A0A7N9D5I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9541:KCNH1
gene id: 9541:KCNH1
uniprot id: A0A2K5TQ71
names: Subcellular Location Annotation
messages: Membrane

9541:HDAC2
gene id: 9541:HDAC2
uniprot id: A0A2K5TJ71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9541:IGF2BP1
gene id: 9541:IGF2BP1
uniprot id: A0A2K5TUQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9541:ARHGEF3
gene id: 9541:ARHGEF3
uniprot id: A0A2K5UNA5
uniprot id: Q9N0A8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm
messages: Interacts with RHOA and RHOB.

9541:ETFDH
gene id: 9541:ETFDH
uniprot id: A0A8J8Y4W4
uniprot id: G7P6H5
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9541:UBE2T
gene id: 9541:UBE2T
uniprot id: A0A2K5U653
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:UMPS
gene id: 9541:UMPS
uniprot id: A0A2K5TYP5
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9541:BRCA1
gene id: 9541:BRCA1
uniprot id: A0A075VSV1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
messages: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.
messages: Nucleus

9541:AVIL
gene id: 9541:AVIL
uniprot id: A0A2K5US22
names: Similarity
messages: Belongs to the villin/gelsolin family.

9541:AOC2
gene id: 9541:AOC2
uniprot id: A0A8J8Y2F1
uniprot id: G7PUW5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9541:KRT222
gene id: 9541:KRT222
uniprot id: A0A8J8YLD5
uniprot id: G7PUP3
names: Similarity
messages: Belongs to the intermediate filament family.

9541:GJD2
gene id: 9541:GJD2
uniprot id: A0A8J8YLU2
uniprot id: G7PAP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:CANT1
gene id: 9541:CANT1
uniprot id: A0A8J8XTK9
uniprot id: G7PT20
names: Similarity
messages: Belongs to the apyrase family.

9541:EZR
gene id: 9541:EZR
uniprot id: A0A2K5W6F0
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9541:PHC1
gene id: 9541:PHC1
uniprot id: A0A2K5UF17
names: Subcellular Location Annotation
messages: Nucleus

9541:JPT1
gene id: 9541:JPT1
uniprot id: A0A2K5V9L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9541:RASGRP2
gene id: 9541:RASGRP2
uniprot id: A0A7N9CIC2
names: Similarity
messages: Belongs to the RASGRP family.

9541:UBE2D1
gene id: 9541:UBE2D1
uniprot id: A0A2K5VRH8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:A1CF
gene id: 9541:A1CF
uniprot id: A0A2K5VBN3
names: Subcellular Location Annotation
messages: Cytoplasm

9541:LOC102133117
gene id: 9541:LOC102133117
uniprot id: A0A7N9D7R8
names: Similarity
messages: Belongs to the histone H3 family.

9541:MED31
gene id: 9541:MED31
uniprot id: A0A8J8YGZ2
uniprot id: G7PTE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9541:LOC102141409
gene id: 9541:LOC102141409
uniprot id: A0A2K5WG65
uniprot id: A0A2K5WUP0
uniprot id: A0A7N9CCJ9
names: Similarity
messages: Belongs to the peptidase M17 family.
messages: Belongs to the syntaxin family.

9541:SLC29A3
gene id: 9541:SLC29A3
uniprot id: A0A2K5X6E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9541:MARF1
gene id: 9541:MARF1
uniprot id: A0A2K5TUD8
names: Subcellular Location Annotation
messages: Peroxisome

9541:PTGDR
gene id: 9541:PTGDR
uniprot id: A0A8J8Y1H0
uniprot id: G7PA94
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:PRKCH
gene id: 9541:PRKCH
uniprot id: A0A2K5UP58
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9541:RHCG
gene id: 9541:RHCG
uniprot id: A0A8J8XKZ0
uniprot id: G7P9E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9541:ALDOC
gene id: 9541:ALDOC
uniprot id: A0A805Q5V7
uniprot id: G7PTX4
uniprot id: Q9GKW3
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Homotetramer. Interacts with ATP6V1E1.
messages: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

9541:GPRC5A
gene id: 9541:GPRC5A
uniprot id: A0A2K5V8R6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:MYO1D
gene id: 9541:MYO1D
uniprot id: A0A2K5V6Z7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:HBS1L
gene id: 9541:HBS1L
uniprot id: A0A2K5WCP7
names: Subcellular Location Annotation
messages: Cytoplasm

9541:TRIAP1
gene id: 9541:TRIAP1
uniprot id: A0A2K5VDY0
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9541:ACMSD
gene id: 9541:ACMSD
uniprot id: A0A7N9CFZ9
uniprot id: A0A7N9IB17
uniprot id: A0A8J8YBQ4
uniprot id: G7PN37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9541:NKG7
gene id: 9541:NKG7
uniprot id: A0A2K5TM29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9541:USP30
gene id: 9541:USP30
uniprot id: A0A8J8XM81
uniprot id: G7PI60
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:GABRG1
gene id: 9541:GABRG1
uniprot id: A0A2K5UQ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:ZDHHC7
gene id: 9541:ZDHHC7
uniprot id: A0A2K5W162
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:SLC6A12
gene id: 9541:SLC6A12
uniprot id: A0A2K5VNR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Lateral cell membrane
messages: Membrane

9541:ATP6V0D1
gene id: 9541:ATP6V0D1
uniprot id: A0A2K5X956
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:DYNLRB2
gene id: 9541:DYNLRB2
uniprot id: A0A2K5UM23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9541:DDIT3
gene id: 9541:DDIT3
uniprot id: A0A2K5VSM5
uniprot id: G7PIV4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9541:KCNK17
gene id: 9541:KCNK17
uniprot id: A0A2K5WSC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9541:PLA2G15
gene id: 9541:PLA2G15
uniprot id: A0A2K5X057
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9541:HIKESHI
gene id: 9541:HIKESHI
uniprot id: A0A2K5V9R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9541:TM9SF4
gene id: 9541:TM9SF4
uniprot id: A0A2K5WM17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9541:EEF1A1
gene id: 9541:EEF1A1
uniprot id: Q4R5K0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9541:TENM1
gene id: 9541:TENM1
uniprot id: A0A2K5U2F0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:STX5
gene id: 9541:STX5
uniprot id: A0A8J8XE24
uniprot id: G7PPS5
names: Similarity
messages: Belongs to the syntaxin family.

9541:SLC39A1
gene id: 9541:SLC39A1
uniprot id: A0A2K5X0P7
uniprot id: A0A7N9CFY9
names: Subcellular Location Annotation
messages: Membrane

9541:GJA4
gene id: 9541:GJA4
uniprot id: G7NTG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:STXBP3
gene id: 9541:STXBP3
uniprot id: A0A2K5X901
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9541:LOC102147203
gene id: 9541:LOC102147203
uniprot id: A0A2K5WYP0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9541:NSFL1C
gene id: 9541:NSFL1C
uniprot id: A0A2K5VJE4
uniprot id: A0A2K5VJS2
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9541:RFC2
gene id: 9541:RFC2
uniprot id: A0A2K5WN91
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9541:CD52
gene id: 9541:CD52
uniprot id: P32763
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

9541:EIF1AD
gene id: 9541:EIF1AD
uniprot id: Q4R354
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Nucleus
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity).

9541:LOC102141103
gene id: 9541:LOC102141103
uniprot id: A0A2K5WH18
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

9541:CIAO1
gene id: 9541:CIAO1
uniprot id: A0A2K5UXP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9541:TFF2
gene id: 9541:TFF2
uniprot id: A0A7N9D9T8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:THRB
gene id: 9541:THRB
uniprot id: A0A2K5UEL1
uniprot id: A0A2K5V0F5
uniprot id: A0A8J8XIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9541:NEK6
gene id: 9541:NEK6
uniprot id: A0A2K5VIW9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:NNT
gene id: 9541:NNT
uniprot id: A0A2K5WQE6
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9541:ATP1A2
gene id: 9541:ATP1A2
uniprot id: A0A2K5UV79
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:GNAS
gene id: 9541:GNAS
uniprot id: Q2PFZ8
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9541:LLPH
gene id: 9541:LLPH
uniprot id: A0A2K5X0J3
names: Similarity
messages: Belongs to the learning-associated protein family.

9541:POU2F1
gene id: 9541:POU2F1
uniprot id: A0A2K5W6C1
uniprot id: A0A2K5W6C9
uniprot id: A0A8J8XNY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9541:CSRNP1
gene id: 9541:CSRNP1
uniprot id: A0A2K5U8N7
uniprot id: A0A7N9CWX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9541:DGUOK
gene id: 9541:DGUOK
uniprot id: A0A2K5VPR5
uniprot id: A0A8J8Y974
uniprot id: G7PMI3
names: Similarity
messages: Belongs to the DCK/DGK family.

9541:TMEM70
gene id: 9541:TMEM70
uniprot id: A0A7N9CGT8
names: Similarity
messages: Belongs to the TMEM70 family.

9541:SERPINB13
gene id: 9541:SERPINB13
uniprot id: A0A7N9CAP2
names: Similarity
messages: Belongs to the serpin family.

9541:PPP2R2C
gene id: 9541:PPP2R2C
uniprot id: A0A2K5U9A3
uniprot id: A0A2K5U9C5
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9541:PRPS1L1
gene id: 9541:PRPS1L1
uniprot id: A0A7N9CH96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9541:LOC102136630
gene id: 9541:LOC102136630
uniprot id: A0A2K5VI22
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9541:DPYSL3
gene id: 9541:DPYSL3
uniprot id: A0A2K5VTE7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9541:RP2
gene id: 9541:RP2
uniprot id: A0A2K5X3D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9541:COQ8A
gene id: 9541:COQ8A
uniprot id: A0A2K5VRC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane

9541:HS3ST2
gene id: 9541:HS3ST2
uniprot id: A0A2K5TNA8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:PPP1CC
gene id: 9541:PPP1CC
uniprot id: A0A2K5WK94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9541:WAS
gene id: 9541:WAS
uniprot id: A0A2K5U1L0
names: Subcellular Location Annotation
messages: Nucleus

9541:HTR1D
gene id: 9541:HTR1D
uniprot id: A0A2K5UMI0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9541:CA1
gene id: 9541:CA1
uniprot id: A0A2K5UCT8
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9541:CCDC89
gene id: 9541:CCDC89
uniprot id: Q95JI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC89 family.
messages: Cytoplasm
messages: Interacts with HEY1.
messages: Nucleus

9541:APTX
gene id: 9541:APTX
uniprot id: Q9BGQ0
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
messages: Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT/PARP1 and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated).
messages: The C2H2-type zinc finger mediates DNA-binding.
messages: The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4.
messages: The HIT domain is required for enzymatic activity.
messages: The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.
messages: nucleolus
messages: nucleoplasm

9541:NMT1
gene id: 9541:NMT1
uniprot id: A0A2K5VEF7
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9541:BCL2L1
gene id: 9541:BCL2L1
uniprot id: A0A2K5VPG2
uniprot id: A0A7N9D351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9541:HNRNPC
gene id: 9541:HNRNPC
uniprot id: A0A2K5U148
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9541:GET3
gene id: 9541:GET3
uniprot id: A0A2K5TPH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9541:FOXH1
gene id: 9541:FOXH1
uniprot id: A0A2K5TPR8
names: Subcellular Location Annotation
messages: Nucleus

9541:EPC2
gene id: 9541:EPC2
uniprot id: A0A2K5WEL3
uniprot id: A0A2K5WEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9541:YAF2
gene id: 9541:YAF2
uniprot id: A0A7N9CQ30
names: Subcellular Location Annotation
messages: Nucleus

9541:KCNMB4
gene id: 9541:KCNMB4
uniprot id: A0A7N9CUG2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9541:P4HA3
gene id: 9541:P4HA3
uniprot id: A0A2K5VBH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9541:MRPL40
gene id: 9541:MRPL40
uniprot id: A0A8J8YSK4
uniprot id: G7PH82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9541:PDGFB
gene id: 9541:PDGFB
uniprot id: A0A2K5UX81
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9541:LOC102146887
gene id: 9541:LOC102146887
uniprot id: A0A2K5VSX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9541:EIF6
gene id: 9541:EIF6
uniprot id: A0A2K5UX53
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9541:AMIGO1
gene id: 9541:AMIGO1
uniprot id: A0A8J8XXM3
uniprot id: G7NV59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9541:CCL28
gene id: 9541:CCL28
uniprot id: A0A8J8XBT9
uniprot id: G7P7G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:SLC10A7
gene id: 9541:SLC10A7
uniprot id: A0A2K5UCL6
uniprot id: A0A2K5UCM4
uniprot id: A0A2K5UCN6
uniprot id: A0A2K5UCN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9541:DOCK5
gene id: 9541:DOCK5
uniprot id: A0A2K5TVL2
names: Similarity
messages: Belongs to the DOCK family.

9541:RNF182
gene id: 9541:RNF182
uniprot id: A0A8J8YJU3
uniprot id: G7P4G4
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9541:BAZ2A
gene id: 9541:BAZ2A
uniprot id: A0A2K5UPU3
uniprot id: A0A2K5UPV6
names: Similarity
messages: Belongs to the WAL family.

9541:USP20
gene id: 9541:USP20
uniprot id: A0A2K5TWN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9541:LOC102126513
gene id: 9541:LOC102126513
uniprot id: A0A2K5ULW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9541:GTF2A1
gene id: 9541:GTF2A1
uniprot id: A0A2K5TKH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9541:LOC102128296
gene id: 9541:LOC102128296
uniprot id: A0A2K5UBG0
uniprot id: A0A2K5UH45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9541:HEPH
gene id: 9541:HEPH
uniprot id: A0A2K5WZ73
uniprot id: G7Q2X1
names: Similarity
messages: Belongs to the multicopper oxidase family.

9541:LOC102120368
gene id: 9541:LOC102120368
uniprot id: A0A2K5UN85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:SPIN4
gene id: 9541:SPIN4
uniprot id: A0A8J8Y5W0
uniprot id: G7Q2W1
names: Similarity
messages: Belongs to the SPIN/STSY family.

9541:PRRX1
gene id: 9541:PRRX1
uniprot id: A0A2K5V1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9541:IFNA8
gene id: 9541:IFNA8
uniprot id: G7PS89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9541:CCR6
gene id: 9541:CCR6
uniprot id: A0A2K5WY45
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:MAU2
gene id: 9541:MAU2
uniprot id: A0A2K5VWV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9541:EIF3M
gene id: 9541:EIF3M
uniprot id: A0A2K5TRB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9541:TLCD5
gene id: 9541:TLCD5
uniprot id: A0A2K5VUC6
uniprot id: A0A7N9IBL8
names: Subcellular Location Annotation
messages: Membrane

9541:MEF2A
gene id: 9541:MEF2A
uniprot id: A0A2K5VXR6
uniprot id: A0A2K5VXV0
names: Subcellular Location Annotation
messages: Nucleus

9541:EMC9
gene id: 9541:EMC9
uniprot id: A0A2K5W141
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9541:SPINK2
gene id: 9541:SPINK2
uniprot id: P34953
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (By similarity). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin (By similarity).
messages: More abundant in epididymis than in testis.
messages: Secreted
messages: Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin (By similarity).
messages: acrosome

9541:LOC102144154
gene id: 9541:LOC102144154
uniprot id: A0A2K5V9A2
uniprot id: G8F4K7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:SYT2
gene id: 9541:SYT2
uniprot id: A0A8J8YJ11
uniprot id: G7NWD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9541:F11R
gene id: 9541:F11R
uniprot id: I7GN79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9541:LOC102121277
gene id: 9541:LOC102121277
uniprot id: A0A2K5UG77
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9541:NR0B2
gene id: 9541:NR0B2
uniprot id: A0A2K5U1Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9541:RTRAF
gene id: 9541:RTRAF
uniprot id: A0A8J8XBC5
uniprot id: G7PA92
names: Similarity
messages: Belongs to the RTRAF family.

9541:MEF2C
gene id: 9541:MEF2C
uniprot id: A0A2K5VQ99
uniprot id: A0A2K5VQF2
uniprot id: A0A7N9IBE8
names: Subcellular Location Annotation
messages: Nucleus

9541:TMEM234
gene id: 9541:TMEM234
uniprot id: A0A2K5VPQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

9541:PPP1R10
gene id: 9541:PPP1R10
uniprot id: A0A8J8XGH1
uniprot id: G7P4L7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9541:PROC
gene id: 9541:PROC
uniprot id: A0A2K5VQK4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:RIBC1
gene id: 9541:RIBC1
uniprot id: A0A8J8YKB8
uniprot id: G7Q2T0
names: Similarity
messages: Belongs to the RIB43A family.

9541:GPR12
gene id: 9541:GPR12
uniprot id: A0A2K5TP16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CEMIP2
gene id: 9541:CEMIP2
uniprot id: A0A2K5W3E0
uniprot id: A0A2K5W3F2
names: Similarity
messages: Belongs to the CEMIP family.

9541:BRF1
gene id: 9541:BRF1
uniprot id: A0A2K5U738
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIB family.
messages: Nucleus

9541:HSD11B1L
gene id: 9541:HSD11B1L
uniprot id: Q6Q7D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Secreted

9541:LOC102120741
gene id: 9541:LOC102120741
uniprot id: G7P2L6
uniprot id: G7P2P0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:INSL4
gene id: 9541:INSL4
uniprot id: A0A2K5VZ81
names: Subcellular Location Annotation
messages: Secreted

9541:RPS21
gene id: 9541:RPS21
uniprot id: A0A2K5U026
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9541:LOC101866303
gene id: 9541:LOC101866303
uniprot id: A0A2K5TZS8
uniprot id: A0A8J8XJ50
names: Similarity
messages: Belongs to the PRAME family.

9541:TKTL1
gene id: 9541:TKTL1
uniprot id: Q4R6M8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Cytoplasm
messages: Homodimer.

9541:IFT43
gene id: 9541:IFT43
uniprot id: A0A7N9CSQ0
names: Similarity
messages: Belongs to the IFT43 family.

9541:FSHB
gene id: 9541:FSHB
uniprot id: G7PQH7
uniprot id: Q6EV79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.
messages: Secreted
messages: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:10612425). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (By similarity).

9541:NFE2L1
gene id: 9541:NFE2L1
uniprot id: A0A2K5V9I7
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9541:MTIF2
gene id: 9541:MTIF2
uniprot id: A0A7N9CHK0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9541:NAV2
gene id: 9541:NAV2
uniprot id: A0A2K5TYX2
uniprot id: A0A2K5TYZ0
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9541:ERLEC1
gene id: 9541:ERLEC1
uniprot id: A0A8J8YBT2
uniprot id: G7PM73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9541:EP300
gene id: 9541:EP300
uniprot id: A0A8J8XI68
uniprot id: G7PFM4
names: Subcellular Location Annotation
messages: Cytoplasm

9541:CAMK2N1
gene id: 9541:CAMK2N1
uniprot id: A0A2K5VVX6
names: Similarity
messages: Belongs to the CAMK2N family.

9541:PKLR
gene id: 9541:PKLR
uniprot id: A0A2K5WL75
names: Similarity
messages: Belongs to the pyruvate kinase family.

9541:INSL5
gene id: 9541:INSL5
uniprot id: A0A8J8XP35
uniprot id: G7NW30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9541:MED9
gene id: 9541:MED9
uniprot id: A0A2K5TYT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9541:SCD
gene id: 9541:SCD
uniprot id: A0A2K5TPH0
uniprot id: G7PDR3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9541:MFSD6
gene id: 9541:MFSD6
uniprot id: A0A2K5UQX5
uniprot id: A0A7N9CQR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9541:LOC102141433
gene id: 9541:LOC102141433
uniprot id: A0A7N9DET8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9541:ARV1
gene id: 9541:ARV1
uniprot id: A0A8J8YFP4
uniprot id: G7NXK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9541:HEXIM2
gene id: 9541:HEXIM2
uniprot id: A0A8J8YBN7
uniprot id: G7PV18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9541:LY6G5C
gene id: 9541:LY6G5C
uniprot id: A0A7N9CQK9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: Secreted

9541:TBX15
gene id: 9541:TBX15
uniprot id: A0A2K5VLD0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:CERS6
gene id: 9541:CERS6
uniprot id: A0A2K5WS77
uniprot id: A0A7N9DG37
uniprot id: A0A8J8YJ84
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9541:SERPINB7
gene id: 9541:SERPINB7
uniprot id: A0A2K5VBF3
names: Similarity
messages: Belongs to the serpin family.

9541:H1-2
gene id: 9541:H1-2
uniprot id: G7P2L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9541:ATP2B2
gene id: 9541:ATP2B2
uniprot id: A0A2K5U4W6
uniprot id: A0A2K5U4Y2
uniprot id: A0A2K5U4Y5
uniprot id: A0A2K5U535
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:HHIPL2
gene id: 9541:HHIPL2
uniprot id: A0A2K5W2J6
names: Similarity
messages: Belongs to the HHIP family.

9541:NIF3L1
gene id: 9541:NIF3L1
uniprot id: A0A8J8XNX5
uniprot id: G7PL60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9541:AURKA
gene id: 9541:AURKA
uniprot id: A0A2K5TW98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9541:DDX3X
gene id: 9541:DDX3X
uniprot id: A0A2K5UCB3
names: Similarity
messages: Belongs to the DEAD box helicase family.

9541:PARP11
gene id: 9541:PARP11
uniprot id: A0A2K5U101
uniprot id: A0A2K5U114
uniprot id: A0A2K5U124
names: Similarity
messages: Belongs to the ARTD/PARP family.

9541:GANAB
gene id: 9541:GANAB
uniprot id: A0A2K5VUH9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9541:PLA2G5
gene id: 9541:PLA2G5
uniprot id: A0A2K5V7P1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9541:HOOK1
gene id: 9541:HOOK1
uniprot id: A0A2K5UAI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9541:GJC1
gene id: 9541:GJC1
uniprot id: A0A2K5UFN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:AFG1L
gene id: 9541:AFG1L
uniprot id: A0A2K5WWA7
uniprot id: A0A7N9DCI3
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9541:GSTCD
gene id: 9541:GSTCD
uniprot id: A0A2K5X8G8
names: Similarity
messages: Belongs to the GSTCD family.

9541:RAB9B
gene id: 9541:RAB9B
uniprot id: A0A8J8YIR9
uniprot id: G7Q3C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9541:N4BP3
gene id: 9541:N4BP3
uniprot id: A0A2K5WDM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Vesicle
messages: dendrite

9541:CNOT2
gene id: 9541:CNOT2
uniprot id: A0A8J8XFT7
uniprot id: G7PI14
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9541:EMC8
gene id: 9541:EMC8
uniprot id: A0A2K5WFV4
uniprot id: A0A8J8YKW4
uniprot id: G7PZW7
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9541:ELOVL6
gene id: 9541:ELOVL6
uniprot id: A0A7N9D0S2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9541:LOC102121500
gene id: 9541:LOC102121500
uniprot id: G7P2N0
uniprot id: Q4R362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9541:GCAT
gene id: 9541:GCAT
uniprot id: I7GL53
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9541:CIT
gene id: 9541:CIT
uniprot id: A0A2K5U1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

9541:CD81
gene id: 9541:CD81
uniprot id: A0A2K5UDJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:RFPL4B
gene id: 9541:RFPL4B
uniprot id: G7P3M3
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SNCA
gene id: 9541:SNCA
uniprot id: G7P5X2
uniprot id: P61142
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
messages: Belongs to the synuclein family.
messages: Cytoplasm
messages: Membrane
messages: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).
messages: Nucleus
messages: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress.
messages: Secreted
messages: Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).
messages: Synapse
messages: Ubiquitinated. The predominant conjugate is the diubiquitinated form.
messages: axon

9541:LOC107126377
gene id: 9541:LOC107126377
uniprot id: A0A8U0WQ25
uniprot id: G8F3V0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:NDUFS8
gene id: 9541:NDUFS8
uniprot id: G7PP61
uniprot id: Q60HE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Interacts with RAB5IF (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity).
messages: Mitochondrion inner membrane

9541:LOC101867156
gene id: 9541:LOC101867156
uniprot id: A0A8J8XCF7
uniprot id: G7P9V7
names: Similarity
messages: Belongs to the Bcl-2 family.

9541:RORB
gene id: 9541:RORB
uniprot id: A0A2K5WSZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9541:SEPTIN1
gene id: 9541:SEPTIN1
uniprot id: G7Q0X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:DCLK1
gene id: 9541:DCLK1
uniprot id: A0A2K5UP49
uniprot id: A0A2K5UP70
uniprot id: A0A8J8XX00
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9541:GC
gene id: 9541:GC
uniprot id: A0A2K5V1W9
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9541:LOC101867207
gene id: 9541:LOC101867207
uniprot id: A0A2K5W2K7
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9541:KCNA10
gene id: 9541:KCNA10
uniprot id: A0A2K5UGF0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:NR5A2
gene id: 9541:NR5A2
uniprot id: A0A2K5U6A3
uniprot id: A0A2K5U6B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9541:BLOC1S1
gene id: 9541:BLOC1S1
uniprot id: A0A2K5TX73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space

9541:SCN3A
gene id: 9541:SCN3A
uniprot id: A0A2K5VS58
uniprot id: A0A2K5VS92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9541:KRT37
gene id: 9541:KRT37
uniprot id: A0A8J8YGF7
uniprot id: G7PUR8
names: Similarity
messages: Belongs to the intermediate filament family.

9541:DPH5
gene id: 9541:DPH5
uniprot id: A0A8J8Y5Q4
uniprot id: G7NV35
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9541:ZDHHC22
gene id: 9541:ZDHHC22
uniprot id: A0A2K5UXY5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:EID2B
gene id: 9541:EID2B
uniprot id: G7PXK1
names: Subcellular Location Annotation
messages: Nucleus

9541:SMC1A
gene id: 9541:SMC1A
uniprot id: A0A8J8XR42
uniprot id: G7Q2S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9541:ZKSCAN1
gene id: 9541:ZKSCAN1
uniprot id: A0A7N9CR92
names: Subcellular Location Annotation
messages: Nucleus

9541:TMCC1
gene id: 9541:TMCC1
uniprot id: A0A8J8XTR9
uniprot id: G7PIM5
names: Similarity
messages: Belongs to the TEX28 family.

9541:ZDHHC3
gene id: 9541:ZDHHC3
uniprot id: A0A2K5U6M7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:PRKCE
gene id: 9541:PRKCE
uniprot id: A0A2K5W8T8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

9541:NSDHL
gene id: 9541:NSDHL
uniprot id: A0A2K5UDV0
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9541:SBNO1
gene id: 9541:SBNO1
uniprot id: A0A2K5UZM4
uniprot id: A0A2K5UZV1
names: Similarity
messages: Belongs to the SBNO family.

9541:EXOSC2
gene id: 9541:EXOSC2
uniprot id: A0A2K5X8R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9541:LOC102123651
gene id: 9541:LOC102123651
uniprot id: A0A2K5TRE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:MNAT1
gene id: 9541:MNAT1
uniprot id: A0A2K5UA85
uniprot id: A0A2K5UA91
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9541:IAH1
gene id: 9541:IAH1
uniprot id: A0A2K5TPY2
uniprot id: A0A7N9DFY3
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9541:TMEM47
gene id: 9541:TMEM47
uniprot id: A0A2K5X8H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9541:CD93
gene id: 9541:CD93
uniprot id: A0A2K5VH53
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SOSTDC1
gene id: 9541:SOSTDC1
uniprot id: G7P190
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ACTN2
gene id: 9541:ACTN2
uniprot id: A0A2K5VVV0
uniprot id: A0A2K5VVZ5
names: Similarity
messages: Belongs to the alpha-actinin family.

9541:LOC102133014
gene id: 9541:LOC102133014
uniprot id: A0A2K5W8U4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9541:LOC102144907
gene id: 9541:LOC102144907
uniprot id: A0A2K5UGW3
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9541:SMU1
gene id: 9541:SMU1
uniprot id: A0A2K5W168
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9541:LOC102143204
gene id: 9541:LOC102143204
uniprot id: A0A8J8YHA3
uniprot id: G7PET2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9541:CSTF2T
gene id: 9541:CSTF2T
uniprot id: G8F2J6
names: Subcellular Location Annotation
messages: Nucleus

9541:B4GALT3
gene id: 9541:B4GALT3
uniprot id: A0A8J8XVR9
uniprot id: G7NXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9541:CDK8
gene id: 9541:CDK8
uniprot id: A0A2K5W7E0
uniprot id: G7PVW1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:STARD13
gene id: 9541:STARD13
uniprot id: A0A2K5VN99
uniprot id: A0A2K5VNE6
uniprot id: A0A7N9ID98
names: Subcellular Location Annotation
messages: Cytoplasm

9541:NDUFAF7
gene id: 9541:NDUFAF7
uniprot id: A0A2K5UX74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9541:GPSM2
gene id: 9541:GPSM2
uniprot id: A0A8J8XYJ0
uniprot id: G7NV46
names: Similarity
messages: Belongs to the GPSM family.

9541:RTN4IP1
gene id: 9541:RTN4IP1
uniprot id: A0A2K5VTM8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9541:HSPB7
gene id: 9541:HSPB7
uniprot id: A0A2K5UE10
uniprot id: A0A7N9IBP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9541:C18H18orf32
gene id: 9541:C18H18orf32
uniprot id: I7G4M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: Lipid droplet
messages: May activate the NF-kappa-B signaling pathway.

9541:KDELR3
gene id: 9541:KDELR3
uniprot id: A0A2K5VZJ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:MAPT
gene id: 9541:MAPT
uniprot id: A0A2K5WB83
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol
messages: dendrite

9541:GPHN
gene id: 9541:GPHN
uniprot id: A0A2K5TLW2
uniprot id: A0A2K5TLW8
uniprot id: A0A2K5TLX8
uniprot id: A0A2K5TLY1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9541:CCR4
gene id: 9541:CCR4
uniprot id: A0A8J8XLQ0
uniprot id: G7NYB7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:IFIT1
gene id: 9541:IFIT1
uniprot id: Q4R5F5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IFIT family.
messages: Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT2 and IFIT3 (By similarity). Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts (via TPR repeats 1-4) with RPL15 (By similarity). Interacts with STING1/MITA and disrupts its interaction with MAVS or TBK1 (By similarity). Interacts with EIF3C and EIF3E (By similarity).
messages: Cytoplasm
messages: ISGylated.
messages: Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism) (By similarity).
messages: Phosphorylated.
messages: RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft.

9541:OSBPL9
gene id: 9541:OSBPL9
uniprot id: A0A2K5VIC3
uniprot id: A0A2K5VII1
uniprot id: A0A2K5VIN8
names: Similarity
messages: Belongs to the OSBP family.

9541:NCF2
gene id: 9541:NCF2
uniprot id: A0A2K5U677
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9541:ALKBH5
gene id: 9541:ALKBH5
uniprot id: A0A2K5TU23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkB family.
messages: Monomer.
messages: Nucleus speckle

9541:UBA5
gene id: 9541:UBA5
uniprot id: A0A7N9CUJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9541:NOL10
gene id: 9541:NOL10
uniprot id: A0A8J8YFH0
uniprot id: G7PLL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9541:CBX5
gene id: 9541:CBX5
uniprot id: A0A2K5WBV7
names: Subcellular Location Annotation
messages: Nucleus

9541:FAM3C
gene id: 9541:FAM3C
uniprot id: A0A2K5VE88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9541:AKTIP
gene id: 9541:AKTIP
uniprot id: Q4R5E1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
messages: Cell membrane
messages: Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. Interacts directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1. May interact with FHIP1A.
messages: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
messages: Cytoplasm
messages: Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.

9541:CASD1
gene id: 9541:CASD1
uniprot id: A0A2K5TX76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

9541:PSMD1
gene id: 9541:PSMD1
uniprot id: A0A2K5U0W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9541:G6PC3
gene id: 9541:G6PC3
uniprot id: A0A2K5U8S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9541:CLIP1
gene id: 9541:CLIP1
uniprot id: A0A2K5VIR8
uniprot id: A0A2K5VIS5
names: Subcellular Location Annotation
messages: cytoskeleton

9541:ZDHHC5
gene id: 9541:ZDHHC5
uniprot id: A0A2K5UWE7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:ING2
gene id: 9541:ING2
uniprot id: A0A7N9CZX0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9541:VTA1
gene id: 9541:VTA1
uniprot id: A0A8J8YMP1
uniprot id: G7P314
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9541:VPS35
gene id: 9541:VPS35
uniprot id: A0A2K5WXX7
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9541:EDN3
gene id: 9541:EDN3
uniprot id: A0A2K5X2K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9541:KARS1
gene id: 9541:KARS1
uniprot id: A0A2K5WZR2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9541:TMEM182
gene id: 9541:TMEM182
uniprot id: A0A2K5W3P3
uniprot id: A0A7N9CPH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9541:LOC102145938
gene id: 9541:LOC102145938
uniprot id: A0A2K5U4K0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:AWAT1
gene id: 9541:AWAT1
uniprot id: A0A8J8XTH0
uniprot id: G7Q2Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9541:LOC102140788
gene id: 9541:LOC102140788
uniprot id: G7P624
uniprot id: P61256
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the large ribosomal subunit. Interacts with DHX33.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9541:TWSG1
gene id: 9541:TWSG1
uniprot id: A0A8J8YIC6
uniprot id: G7PWD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

9541:MGAT4C
gene id: 9541:MGAT4C
uniprot id: Q4R4A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity).
messages: Golgi apparatus membrane

9541:SIKE1
gene id: 9541:SIKE1
uniprot id: A0A2K5V835
uniprot id: A0A7N9CJ40
names: Similarity
messages: Belongs to the SIKE family.

9541:ASB11
gene id: 9541:ASB11
uniprot id: A0A2K5W1E1
uniprot id: A0A2K5W1E6
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:DLK1
gene id: 9541:DLK1
uniprot id: A0A2K5TMQ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:MAPK1
gene id: 9541:MAPK1
uniprot id: A0A2K5TXF6
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola
messages: focal adhesion

9541:GPR161
gene id: 9541:GPR161
uniprot id: A0A2K5WLY0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:RHBDL3
gene id: 9541:RHBDL3
uniprot id: A0A2K5U5G2
uniprot id: A0A2K5U5J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9541:TADA1
gene id: 9541:TADA1
uniprot id: A0A8J8Y822
uniprot id: G7NU37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9541:YPEL2
gene id: 9541:YPEL2
uniprot id: A0A2K5WCK4
names: Similarity
messages: Belongs to the yippee family.

9541:LOC102141746
gene id: 9541:LOC102141746
uniprot id: A0A2K5TRT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9541:PHKB
gene id: 9541:PHKB
uniprot id: A0A2K5VG98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9541:CLSTN3
gene id: 9541:CLSTN3
uniprot id: A0A2K5W1F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

9541:DNAJC18
gene id: 9541:DNAJC18
uniprot id: A0A2K5TS89
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:INTS12
gene id: 9541:INTS12
uniprot id: G7P614
uniprot id: Q8WNV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
messages: Nucleus

9541:CPNE8
gene id: 9541:CPNE8
uniprot id: A0A8J8YL94
uniprot id: G7PHL3
names: Similarity
messages: Belongs to the copine family.

9541:SUB1
gene id: 9541:SUB1
uniprot id: Q25NQ4
uniprot id: Q4R947
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA (By similarity).
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity).
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2 (By similarity).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9541:STAG1
gene id: 9541:STAG1
uniprot id: A0A8J8XEF3
uniprot id: G7NXX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9541:ELK3
gene id: 9541:ELK3
uniprot id: A0A8J8YAT6
uniprot id: G7PJ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:KEG98 p04
gene id: 9541:KEG98_p04
uniprot id: C3W4Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9541:ACADL
gene id: 9541:ACADL
uniprot id: A0A7N9D315
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

9541:EIF4G1
gene id: 9541:EIF4G1
uniprot id: A0A2K5WFX9
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9541:EHD3
gene id: 9541:EHD3
uniprot id: A0A2K5V6F2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9541:TCTN2
gene id: 9541:TCTN2
uniprot id: A0A2K5UYQ3
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9541:MRPS18B
gene id: 9541:MRPS18B
uniprot id: A0A7N9CYI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

9541:ZSCAN12
gene id: 9541:ZSCAN12
uniprot id: A0A2K5WRS2
names: Subcellular Location Annotation
messages: Nucleus

9541:PRRT2
gene id: 9541:PRRT2
uniprot id: A0A7N9DDH4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:LEPROT
gene id: 9541:LEPROT
uniprot id: A0A2K5TJ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9541:UGCG
gene id: 9541:UGCG
uniprot id: A0A2K5WQV5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9541:DDX50
gene id: 9541:DDX50
uniprot id: A0A2K5VK31
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9541:PIP4P2
gene id: 9541:PIP4P2
uniprot id: A0A2K5VN62
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9541:LOC102124556
gene id: 9541:LOC102124556
uniprot id: G7P1K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9541:SNTG1
gene id: 9541:SNTG1
uniprot id: A0A2K5WF09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9541:CCL27
gene id: 9541:CCL27
uniprot id: A0A2K5W9R6
names: Subcellular Location Annotation
messages: Secreted

9541:EYA3
gene id: 9541:EYA3
uniprot id: A0A2K5VTC8
uniprot id: A0A2K5VTE3
uniprot id: A0A8J8YLN9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9541:LOC102140676
gene id: 9541:LOC102140676
uniprot id: A0A2K5ULD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CABIN1
gene id: 9541:CABIN1
uniprot id: A0A2K5VWI8
uniprot id: A0A2K5VWX3
names: Subcellular Location Annotation
messages: Nucleus

9541:RPL12
gene id: 9541:RPL12
uniprot id: A0A2K5UBV0
uniprot id: G8F4M8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9541:MMP14
gene id: 9541:MMP14
uniprot id: A0A8J8XW92
uniprot id: G7P9U2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Cytoplasm
messages: Melanosome

9541:NDUFA4
gene id: 9541:NDUFA4
uniprot id: Q4R542
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex IV NDUFA4 subunit family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance.
messages: Mitochondrion inner membrane

9541:RDH8
gene id: 9541:RDH8
uniprot id: A0A8J8YHB7
uniprot id: G7PZ59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

9541:TIMM8B
gene id: 9541:TIMM8B
uniprot id: G7PNT5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9541:TRAPPC2
gene id: 9541:TRAPPC2
uniprot id: I7G790
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9541:USP45
gene id: 9541:USP45
uniprot id: A0A2K5WNX1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:LOC102134176
gene id: 9541:LOC102134176
uniprot id: Q9TSM6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome
messages: Endoplasmic reticulum
messages: Farnesylated. Farnesylation is required for membrane targeting (By similarity).
messages: Homotrimer. Interacts with ATF5 and tubulin (By similarity).
messages: In the retina, expressed by red/green- but not blue-sensitive cone photoreceptor cells, and by rod bipolar cells (at protein level).
messages: Inhibited by sodium orthovanadate and pentamidine.
messages: Nucleus
messages: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
messages: spindle

9541:MEIG1
gene id: 9541:MEIG1
uniprot id: A0A8J8XDF9
uniprot id: G7PEF2
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9541:MED30
gene id: 9541:MED30
uniprot id: A0A2K5UZT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9541:COPG1
gene id: 9541:COPG1
uniprot id: A0A2K5UZF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9541:RDH5
gene id: 9541:RDH5
uniprot id: A0A8J8YRR1
uniprot id: G7PIF1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:MMP2
gene id: 9541:MMP2
uniprot id: A0A2K5W5A4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

9541:AK4
gene id: 9541:AK4
uniprot id: A0A2K5UMF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9541:SLC35F1
gene id: 9541:SLC35F1
uniprot id: A0A2K5VES8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9541:YKT6
gene id: 9541:YKT6
uniprot id: A0A2K5VBW3
uniprot id: A0A7N9IDJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9541:STAT6
gene id: 9541:STAT6
uniprot id: A0A2K5W338
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9541:INKA2
gene id: 9541:INKA2
uniprot id: A0A2K5TR15
uniprot id: A0A7N9D0M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9541:IDNK
gene id: 9541:IDNK
uniprot id: A0A2K5UJQ4
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

9541:NEU1
gene id: 9541:NEU1
uniprot id: A0A2K5WS75
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9541:PDE7A
gene id: 9541:PDE7A
uniprot id: A0A2K5WGM8
uniprot id: A0A8J8XNN1
uniprot id: G7PBY0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:SARM1
gene id: 9541:SARM1
uniprot id: A0A2K5UA73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARM1 family.
messages: axon

9541:LOC102122186
gene id: 9541:LOC102122186
uniprot id: G7P0E5
names: Subcellular Location Annotation
messages: Membrane

9541:SCD5
gene id: 9541:SCD5
uniprot id: A0A2K5W2B7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9541:LOC102127157
gene id: 9541:LOC102127157
uniprot id: G8F5F7
names: Subcellular Location Annotation
messages: Membrane

9541:NSMCE2
gene id: 9541:NSMCE2
uniprot id: A0A2K5W0K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

9541:NLK
gene id: 9541:NLK
uniprot id: A0A7N9IE49
uniprot id: A0A8J8Y4V7
uniprot id: G7PTW3
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9541:NMI
gene id: 9541:NMI
uniprot id: A0A2K5VU13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9541:GK5
gene id: 9541:GK5
uniprot id: A0A7N9IBB2
names: Similarity
messages: Belongs to the FGGY kinase family.

9541:CDA
gene id: 9541:CDA
uniprot id: A0A2K5TSB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

9541:RORC
gene id: 9541:RORC
uniprot id: A0A2K5UAQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9541:TMEM54
gene id: 9541:TMEM54
uniprot id: A0A2K5U810
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9541:VTI1A
gene id: 9541:VTI1A
uniprot id: A0A2K5V402
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9541:CLDN12
gene id: 9541:CLDN12
uniprot id: A0A2K5UH12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9541:NTSR1
gene id: 9541:NTSR1
uniprot id: A0A2K5UQ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LOC102134374
gene id: 9541:LOC102134374
uniprot id: G7P6T4
uniprot id: Q4R6P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Component of the small ribosomal subunit. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: Membrane
messages: nucleolus

9541:IL2RG
gene id: 9541:IL2RG
uniprot id: A0A2K5VGJ6
uniprot id: A0A8J8XHR2
names: Subcellular Location Annotation
messages: Membrane

9541:SERPIND1
gene id: 9541:SERPIND1
uniprot id: A0A2K5UTW1
names: Similarity
messages: Belongs to the serpin family.

9541:ATP5MC1
gene id: 9541:ATP5MC1
uniprot id: A0A8J8Y9Z4
uniprot id: G7P524
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9541:LOC102120351
gene id: 9541:LOC102120351
uniprot id: A0A2K5W5F7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9541:CRYBB1
gene id: 9541:CRYBB1
uniprot id: A0A2K5TPY4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:SEPSECS
gene id: 9541:SEPSECS
uniprot id: A0A2K5WAA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9541:PIK3CG
gene id: 9541:PIK3CG
uniprot id: A0A2K5V7M8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9541:SLC35E2B
gene id: 9541:SLC35E2B
uniprot id: A0A2K5TL70
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102143578
gene id: 9541:LOC102143578
uniprot id: A0A2K5TKJ2
uniprot id: A0A8J8YDL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

9541:TAF6
gene id: 9541:TAF6
uniprot id: A0A8J8YMH2
uniprot id: G7P0C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9541:FLOT1
gene id: 9541:FLOT1
uniprot id: A0A8J8XNG8
uniprot id: G7P4M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9541:USP5
gene id: 9541:USP5
uniprot id: A0A2K5UA78
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:TMEM147
gene id: 9541:TMEM147
uniprot id: A0A2K5WNQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM147 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

9541:CTSW
gene id: 9541:CTSW
uniprot id: A0A2K5TYS6
names: Similarity
messages: Belongs to the peptidase C1 family.

9541:SERPINA3
gene id: 9541:SERPINA3
uniprot id: A0A2K5VSD9
names: Similarity
messages: Belongs to the serpin family.

9541:ZMPSTE24
gene id: 9541:ZMPSTE24
uniprot id: A0A2K5VKS8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9541:PLA2G4A
gene id: 9541:PLA2G4A
uniprot id: A0A2K5VI33
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9541:CRK
gene id: 9541:CRK
uniprot id: A0A2K5X7X9
names: Similarity
messages: Belongs to the CRK family.

9541:CLCN2
gene id: 9541:CLCN2
uniprot id: A0A8J8XAS7
uniprot id: G7NYZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

9541:RPS9
gene id: 9541:RPS9
uniprot id: A0A8J8YSV3
uniprot id: G7PYS4
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9541:NPPB
gene id: 9541:NPPB
uniprot id: A0A2K5V0K8
uniprot id: G8F4Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9541:NR2E1
gene id: 9541:NR2E1
uniprot id: A0A2K5TWE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:PIR
gene id: 9541:PIR
uniprot id: A0A2K5V2H4
uniprot id: G7Q298
names: Similarity
messages: Belongs to the pirin family.

9541:RPN2
gene id: 9541:RPN2
uniprot id: A0A2K5UST6
uniprot id: A0A2K5USU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9541:NGB
gene id: 9541:NGB
uniprot id: A0A7N9CWQ6
names: Similarity
messages: Belongs to the globin family.

9541:LOC102147033
gene id: 9541:LOC102147033
uniprot id: A0A7N9CD12
names: Similarity
messages: Belongs to the MOB1/phocein family.

9541:STAC2
gene id: 9541:STAC2
uniprot id: A0A2K5WQY8
names: Subcellular Location Annotation
messages: sarcolemma

9541:SULT1C4
gene id: 9541:SULT1C4
uniprot id: A0A2K5X358
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:CAVIN4
gene id: 9541:CAVIN4
uniprot id: A0A2K5VJ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9541:TNNT2
gene id: 9541:TNNT2
uniprot id: A0A2K5WBC9
uniprot id: A0A2K5WBT9
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9541:OSBPL7
gene id: 9541:OSBPL7
uniprot id: A0A2K5TT73
uniprot id: A0A2K5U737
names: Similarity
messages: Belongs to the OSBP family.

9541:GGCX
gene id: 9541:GGCX
uniprot id: A0A8J8XEH1
uniprot id: G7PMM1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LRRC8C
gene id: 9541:LRRC8C
uniprot id: A0A8J8YIA7
uniprot id: G7NTM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9541:ABAT
gene id: 9541:ABAT
uniprot id: A0A2K5UZZ0
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9541:TMEM266
gene id: 9541:TMEM266
uniprot id: Q9N0B5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Perikaryon
messages: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Transplantation of the transmembrane segment S4 into HVCN1, generates a functional voltage-activated proton channel.
messages: Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition.
messages: dendrite

9541:SKAP2
gene id: 9541:SKAP2
uniprot id: A0A2K5X5C8
uniprot id: A0A979HKE4
names: Similarity
messages: Belongs to the SKAP family.

9541:VAPB
gene id: 9541:VAPB
uniprot id: A0A2K5WHF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:MFNG
gene id: 9541:MFNG
uniprot id: A0A7N9I9E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:GRIA1
gene id: 9541:GRIA1
uniprot id: A0A7N9D6X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:CLRN2
gene id: 9541:CLRN2
uniprot id: A0A2K5UUA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9541:NKAPL
gene id: 9541:NKAPL
uniprot id: A0A7N9CJD0
names: Similarity
messages: Belongs to the NKAP family.

9541:CRB1
gene id: 9541:CRB1
uniprot id: A0A2K5TN44
uniprot id: A0A8J8Y5Q7
uniprot id: G7NWI2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TAS2R10
gene id: 9541:TAS2R10
uniprot id: A0A7N9CV58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:RCAN3
gene id: 9541:RCAN3
uniprot id: A0A8J8YCU2
uniprot id: G7NVW0
names: Similarity
messages: Belongs to the RCAN family.

9541:LOC102123081
gene id: 9541:LOC102123081
uniprot id: Q4R3H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9541:PDE3A
gene id: 9541:PDE3A
uniprot id: A0A2K5VAH0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:PDC
gene id: 9541:PDC
uniprot id: A0A2K5U750
names: Similarity
messages: Belongs to the phosducin family.

9541:PLAC1
gene id: 9541:PLAC1
uniprot id: G7Q1Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9541:RPL26
gene id: 9541:RPL26
uniprot id: G7P624
uniprot id: P61256
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the large ribosomal subunit. Interacts with DHX33.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9541:MAF1
gene id: 9541:MAF1
uniprot id: A0A8J8XHI8
uniprot id: G7PDA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

9541:GCNT2
gene id: 9541:GCNT2
uniprot id: A0A7N9CM24
uniprot id: A0A8J8Y4A2
uniprot id: G7P4D9
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9541:TMCC3
gene id: 9541:TMCC3
uniprot id: A0A2K5U6U3
names: Similarity
messages: Belongs to the TEX28 family.

9541:STING1
gene id: 9541:STING1
uniprot id: A0A2R3XZA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9541:LOC102121015
gene id: 9541:LOC102121015
uniprot id: A0A7N9CR08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:DLAT
gene id: 9541:DLAT
uniprot id: A0A2K5UNA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9541:RDH10
gene id: 9541:RDH10
uniprot id: A0A2K5UW13
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:SNRPN
gene id: 9541:SNRPN
uniprot id: Q25QJ5
uniprot id: Q60HD3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP SmB/SmN family.
messages: Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.
messages: Interacts with TDRD3.
messages: May be involved in tissue-specific alternative RNA processing events.
messages: Nucleus

9541:E2F7
gene id: 9541:E2F7
uniprot id: A0A2K5X799
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9541:ANAPC1
gene id: 9541:ANAPC1
uniprot id: A0A2K5X245
names: Similarity
messages: Belongs to the APC1 family.

9541:MPP1
gene id: 9541:MPP1
uniprot id: A0A2K5WSK7
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

9541:CD37
gene id: 9541:CD37
uniprot id: A0A2K5V5D2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:TRIM54
gene id: 9541:TRIM54
uniprot id: A0A2K5WLK1
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9541:LXN
gene id: 9541:LXN
uniprot id: A0A2K5WLX9
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9541:TNFSF10
gene id: 9541:TNFSF10
uniprot id: I7GIW0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9541:CBX2
gene id: 9541:CBX2
uniprot id: A0A7N9CZ26
names: Subcellular Location Annotation
messages: Nucleus

9541:RBBP5
gene id: 9541:RBBP5
uniprot id: A0A2K5WQ72
names: Subcellular Location Annotation
messages: Nucleus

9541:BRCC3
gene id: 9541:BRCC3
uniprot id: A0A2K5UU36
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9541:RRM2
gene id: 9541:RRM2
uniprot id: A0A2K5TSY5
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9541:TULP1
gene id: 9541:TULP1
uniprot id: A0A2K5U007
uniprot id: A0A2K5U043
names: Similarity
messages: Belongs to the TUB family.

9541:LOC101867505
gene id: 9541:LOC101867505
uniprot id: A0A2K5U3W6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

9541:SERPINA7
gene id: 9541:SERPINA7
uniprot id: A0A2K5WSY1
names: Similarity
messages: Belongs to the serpin family.

9541:INTS3
gene id: 9541:INTS3
uniprot id: A0A2K5UIL5
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9541:RPL13
gene id: 9541:RPL13
uniprot id: A0A2K5UL98
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

9541:ING3
gene id: 9541:ING3
uniprot id: A0A2K5VMH5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9541:TMEM138
gene id: 9541:TMEM138
uniprot id: A0A8J8YQ93
uniprot id: G7PPY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9541:NPY5R
gene id: 9541:NPY5R
uniprot id: G8F2E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

9541:GRIA2
gene id: 9541:GRIA2
uniprot id: A0A2K5TLX4
uniprot id: A0A2K5TLY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:HMGCS1
gene id: 9541:HMGCS1
uniprot id: A0A2K5TMZ2
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9541:KCNB2
gene id: 9541:KCNB2
uniprot id: A0A2K5X219
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: dendrite

9541:EML1
gene id: 9541:EML1
uniprot id: A0A2K5VFJ1
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9541:SPATA18
gene id: 9541:SPATA18
uniprot id: Q95K37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain).
messages: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).
messages: Mitochondrion outer membrane

9541:LOC102115394
gene id: 9541:LOC102115394
uniprot id: A0A7N9CNV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:L3MBTL3
gene id: 9541:L3MBTL3
uniprot id: A0A2K5TJX0
names: Subcellular Location Annotation
messages: Nucleus

9541:ACO2
gene id: 9541:ACO2
uniprot id: A0A7N9D0G3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

9541:FOXJ3
gene id: 9541:FOXJ3
uniprot id: A0A2K5WHE4
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102124180
gene id: 9541:LOC102124180
uniprot id: A0A8J8YHN0
uniprot id: G7Q335
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9541:DCLK2
gene id: 9541:DCLK2
uniprot id: A0A2K5TVN1
uniprot id: A0A2K5TVQ0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9541:HSP90AB1
gene id: 9541:HSP90AB1
uniprot id: Q4R4T5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cell membrane
messages: Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: ISGylated.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Melanosome
messages: Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylatio…
messages: Monomer. Homodimer (By similarity). Forms a complex with CDK6 and CDC37. Interacts with UNC45A; binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity). Interacts with CHORDC1 (By similarity). Interacts with DNAJC7. Interacts with FKBP4. May interact with NWD1. Interacts with SGTA. Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with STUB1 and SMAD3. Interacts with XPO1 and AHSA1. Interacts with BIRC2. Interacts with KCNQ4; promotes cell surface expression of KCNQ4. Interacts with BIRC2; prevents auto-ubiquitination and degradation of its client protein BIRC2. Interacts with NOS3. Interacts with AHR; interaction is inhibited by HSP90AB1 phosphorylation on Ser-226 and Ser-255. Interacts with STIP1 and CDC37; upon SMYD2-dependent methylation. Interacts with JAK2 and PRKCE; promotes functional activation in a heat shock-dependent manner. Interacts with HSP90AA1; interaction is constitutive. HSP90AB1-CDC37 chaperone complex interacts with inactive MAPK7 (via N-terminal half) in resting cells; the interaction is MAP2K5-independent and prevents from ubiquitination and proteasomal degradation. Interacts with CDC25A; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression. Interacts with TP53 (via DNA binding domain); suppresses TP53 aggregation and prevents from irreversible thermal inactivation. Interacts with TGFB1 processed form (LAP); inhibits latent TGFB1 activation (By similarity). Interacts with TRIM8; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1 (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with PDCL3 (By similarity). Interacts with TTC4 (via TPR repeats) (By similarity). Interacts with IL1B; the interac…
messages: Nucleus
messages: Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide. Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction.
messages: S-nitrosylated; negatively regulates the ATPase activity.
messages: Secreted
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
messages: Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).

9541:H1-5
gene id: 9541:H1-5
uniprot id: A0A2K5UCF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9541:PGM2L1
gene id: 9541:PGM2L1
uniprot id: A0A7N9CAA4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9541:PRKG2
gene id: 9541:PRKG2
uniprot id: A0A8J8XQ94
uniprot id: G7P527
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9541:OTOP2
gene id: 9541:OTOP2
uniprot id: A0A2K5VR41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9541:CAV1
gene id: 9541:CAV1
uniprot id: I7GJT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9541:PRDM5
gene id: 9541:PRDM5
uniprot id: A0A2K5U1G2
uniprot id: A0A2K5U1I4
names: Subcellular Location Annotation
messages: Nucleus

9541:PNOC
gene id: 9541:PNOC
uniprot id: A0A2K5VPQ6
uniprot id: G7PCZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9541:MITF
gene id: 9541:MITF
uniprot id: A0A2K5WMF9
uniprot id: G7NZ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9541:MPV17L2
gene id: 9541:MPV17L2
uniprot id: A0A2K5WWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9541:LOC101925699
gene id: 9541:LOC101925699
uniprot id: A0A2K5TQS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:TXNL4B
gene id: 9541:TXNL4B
uniprot id: A0A7N9IA00
uniprot id: A0A8J8YJA8
uniprot id: G7Q1J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9541:APOA2
gene id: 9541:APOA2
uniprot id: G7NXA8
uniprot id: P18656
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A2 family.
messages: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
messages: Monomer. Interacts with NAXE and NDRG1 (By similarity).
messages: Plasma.
messages: Secreted

9541:BPGM
gene id: 9541:BPGM
uniprot id: Q4R6L7
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: At alkaline pH BPGM favors the synthase reaction; however, at lower pH the phosphatase reaction is dominant. Inhibited by citrate.
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Homodimer.
messages: Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity.

9541:GUCA2A
gene id: 9541:GUCA2A
uniprot id: A0A2K5UVW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9541:COG3
gene id: 9541:COG3
uniprot id: A0A2K5V650
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9541:CXCL10
gene id: 9541:CXCL10
uniprot id: A0A2K5WKN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:RPL24
gene id: 9541:RPL24
uniprot id: P61122
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: Mono-ADP-ribosylation at Glu-4 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.

9541:ADAM5
gene id: 9541:ADAM5
uniprot id: Q28483
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Detected in elongate spermatids, and in caput and cauda epididymal spermatozoa (at protein level).
messages: Detected in testis (at protein level). Detected in adult and prepubertal testis. Detected at very low levels in heart, kidney, brain, muscle ovary and uterus.
messages: Interacts with TEX101.
messages: Membrane
messages: Not expected to have protease activity.
messages: Subject to proteolytic processing during epididymal transit of spermatozoa.
messages: This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity).

9541:PDE6C
gene id: 9541:PDE6C
uniprot id: A0A2K5TRP4
uniprot id: A0A8J8XK22
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:TRAPPC2B
gene id: 9541:TRAPPC2B
uniprot id: I7G790
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9541:ACSS2
gene id: 9541:ACSS2
uniprot id: A0A2K5WIE2
uniprot id: A0A7N9CN34
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:SCGN
gene id: 9541:SCGN
uniprot id: A0A8J8YES1
uniprot id: G7P4K7
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9541:SLC7A3
gene id: 9541:SLC7A3
uniprot id: A0A2K5U070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9541:LCN1
gene id: 9541:LCN1
uniprot id: A0A2K5X6M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9541:CHD8
gene id: 9541:CHD8
uniprot id: A0A2K5U6M5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

9541:LOC102118042
gene id: 9541:LOC102118042
uniprot id: A0A8J8YC99
uniprot id: G7NZQ6
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9541:POLD2
gene id: 9541:POLD2
uniprot id: A0A8J8YHG8
uniprot id: Q4R5Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9541:RARS2
gene id: 9541:RARS2
uniprot id: A0A8J8YQB1
uniprot id: G7P3K3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:YWHAQ
gene id: 9541:YWHAQ
uniprot id: A0A7N9DCE6
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
messages: Belongs to the 14-3-3 family.

9541:GABRQ
gene id: 9541:GABRQ
uniprot id: A0A2K5WU49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:RSPO3
gene id: 9541:RSPO3
uniprot id: A0A2K5UTQ7
names: Similarity
messages: Belongs to the R-spondin family.

9541:PARP12
gene id: 9541:PARP12
uniprot id: A0A2K5WHU5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9541:B9D1
gene id: 9541:B9D1
uniprot id: A0A2K5TKM2
names: Subcellular Location Annotation
messages: cilium basal body

9541:CSF2
gene id: 9541:CSF2
uniprot id: A0A2K5UJ69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9541:MANBAL
gene id: 9541:MANBAL
uniprot id: A0A8J8XIZ4
uniprot id: G7PGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9541:SELENOS
gene id: 9541:SELENOS
uniprot id: A0A2K5U765
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
messages: Membrane

9541:FAXC
gene id: 9541:FAXC
uniprot id: A0A2K5WWM2
names: Similarity
messages: Belongs to the FAX family.

9541:NCR3
gene id: 9541:NCR3
uniprot id: P61483
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation.
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.

9541:SPR
gene id: 9541:SPR
uniprot id: A0A8J8YLX2
uniprot id: G7PMG9
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9541:SLC25A3
gene id: 9541:SLC25A3
uniprot id: A0A2K5U6E8
uniprot id: I7G9S2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9541:FLCN
gene id: 9541:FLCN
uniprot id: A0A7N9DCK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9541:CDK6
gene id: 9541:CDK6
uniprot id: A0A8J8XB64
uniprot id: G7P1D7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:SGCG
gene id: 9541:SGCG
uniprot id: A0A2K5W3M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9541:PLRG1
gene id: 9541:PLRG1
uniprot id: A0A2K5TWH6
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9541:RSPH3
gene id: 9541:RSPH3
uniprot id: A0A8J8XMF0
uniprot id: Q4R672
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flagellar radial spoke RSP3 family.
messages: flagellum axoneme

9541:CTNNBL1
gene id: 9541:CTNNBL1
uniprot id: A0A2K5X1L3
names: Subcellular Location Annotation
messages: Nucleus

9541:BMP3
gene id: 9541:BMP3
uniprot id: A0A2K5V439
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9541:ELF5
gene id: 9541:ELF5
uniprot id: A0A8J8Y0W6
uniprot id: G7PQE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:PRR5L
gene id: 9541:PRR5L
uniprot id: A0A7N9DDG5
names: Similarity
messages: Belongs to the PROTOR family.

9541:GPR34
gene id: 9541:GPR34
uniprot id: Q2ACI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor.

9541:TRAF5
gene id: 9541:TRAF5
uniprot id: A0A2K5X0F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9541:OTX2
gene id: 9541:OTX2
uniprot id: A0A2K5TL55
uniprot id: G7PAC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9541:SLC16A12
gene id: 9541:SLC16A12
uniprot id: A0A2K5WEE5
names: Subcellular Location Annotation
messages: Membrane

9541:GLRX
gene id: 9541:GLRX
uniprot id: Q25N99
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9541:ACTR10
gene id: 9541:ACTR10
uniprot id: A0A2K5UFH8
names: Similarity
messages: Belongs to the actin family.

9541:RTN2
gene id: 9541:RTN2
uniprot id: A0A2K5U0A3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LOC102132662
gene id: 9541:LOC102132662
uniprot id: F8RBU3
names: Similarity
messages: Belongs to the MHC class II family.

9541:KXD1
gene id: 9541:KXD1
uniprot id: A0A2K5VQP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9541:ALG5
gene id: 9541:ALG5
uniprot id: A0A8J8YEI8
uniprot id: G7PW14
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9541:MB
gene id: 9541:MB
uniprot id: G7PFA9
uniprot id: P02150
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9541:KCTD3
gene id: 9541:KCTD3
uniprot id: A0A2K5VDD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KCTD3 family.
messages: Cell membrane

9541:SLC26A4
gene id: 9541:SLC26A4
uniprot id: A0A2K5WWN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

9541:CYP27B1
gene id: 9541:CYP27B1
uniprot id: A0A2K5TTY3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:PPT2
gene id: 9541:PPT2
uniprot id: A0A2K5UI68
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9541:ERBB2
gene id: 9541:ERBB2
uniprot id: A0A2K5WUT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9541:CUZD1
gene id: 9541:CUZD1
uniprot id: A0A2K5U5M7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SCN2A
gene id: 9541:SCN2A
uniprot id: A0A2K5TT06
uniprot id: A0A2K5TT46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9541:TM4SF18
gene id: 9541:TM4SF18
uniprot id: A0A7N9CA86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9541:SEH1L
gene id: 9541:SEH1L
uniprot id: A0A2K5UCH9
uniprot id: A0A7N9D3S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9541:ABCC9
gene id: 9541:ABCC9
uniprot id: A0A2K5VZ71
uniprot id: A0A2K5VZC3
uniprot id: A0A2K5VZD7
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

9541:LOC102124095
gene id: 9541:LOC102124095
uniprot id: A0A2K5UQY2
names: Subcellular Location Annotation
messages: Secreted

9541:THOC6
gene id: 9541:THOC6
uniprot id: A0A8J8XWH0
uniprot id: G7Q0B3
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9541:GPKOW
gene id: 9541:GPKOW
uniprot id: A0A8J8XSZ1
uniprot id: G7Q2P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus
messages: RNA-binding protein involved in pre-mRNA splicing.

9541:RPS6KA3
gene id: 9541:RPS6KA3
uniprot id: A0A7N9CBN5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9541:PPP2R5A
gene id: 9541:PPP2R5A
uniprot id: A0A2K5WHQ3
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9541:SGIP1
gene id: 9541:SGIP1
uniprot id: A0A2K5VU08
names: Function
names: Subcellular Location Annotation
messages: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
messages: clathrin-coated pit

9541:FAM72A
gene id: 9541:FAM72A
uniprot id: A0A8J8XC11
uniprot id: G7NVB7
names: Similarity
messages: Belongs to the FAM72 family.

9541:PLPP3
gene id: 9541:PLPP3
uniprot id: A0A2K5UKK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9541:RAB29
gene id: 9541:RAB29
uniprot id: A0A2K5WXI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9541:IFITM5
gene id: 9541:IFITM5
uniprot id: A0A2K5VMX3
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:HBEGF
gene id: 9541:HBEGF
uniprot id: A0A2K5VHS5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:MFAP1
gene id: 9541:MFAP1
uniprot id: A0A8J8XU30
uniprot id: Q4R7A1
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9541:CCL25
gene id: 9541:CCL25
uniprot id: A0A2K5TSD9
names: Subcellular Location Annotation
messages: Secreted

9541:REM1
gene id: 9541:REM1
uniprot id: A0A2K5W106
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9541:TFDP2
gene id: 9541:TFDP2
uniprot id: A0A2K5WZQ7
uniprot id: A0A2K5WZQ9
uniprot id: A0A2K5WZR4
uniprot id: A0A7N9CWX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9541:PGC
gene id: 9541:PGC
uniprot id: A0A2K5U1R3
uniprot id: A0A8J8Y3M3
uniprot id: G7P3W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted

9541:POU4F2
gene id: 9541:POU4F2
uniprot id: A0A2K5WWY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9541:LOC102139187
gene id: 9541:LOC102139187
uniprot id: A0A2K5U1F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

9541:KEG98 p11
gene id: 9541:KEG98_p11
uniprot id: C3W4Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9541:SUV39H2
gene id: 9541:SUV39H2
uniprot id: A0A2K5UW32
uniprot id: Q4R3E0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Interacts with SMAD5. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex (By similarity).
messages: Nucleus
messages: Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation.
messages: centromere

9541:BCL2L13
gene id: 9541:BCL2L13
uniprot id: A0A2K5VXX2
names: Similarity
messages: Belongs to the Bcl-2 family.

9541:LYG1
gene id: 9541:LYG1
uniprot id: A0A2K5UZA1
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9541:EZH1
gene id: 9541:EZH1
uniprot id: A0A2K5V0B8
names: Subcellular Location Annotation
messages: Nucleus

9541:MYO5A
gene id: 9541:MYO5A
uniprot id: A0A2K5W139
uniprot id: A0A2K5W143
uniprot id: A0A2K5W1G4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:CD55
gene id: 9541:CD55
uniprot id: A0A2K5X1V4
uniprot id: A0A2K5X1Z0
uniprot id: A0A7N9CFZ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PPP2CB
gene id: 9541:PPP2CB
uniprot id: A0A2K5X5X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9541:GPR87
gene id: 9541:GPR87
uniprot id: A0A2K5WBA8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:SH2B3
gene id: 9541:SH2B3
uniprot id: A0A7N9CRG6
names: Similarity
messages: Belongs to the SH2B adapter family.

9541:CACNG4
gene id: 9541:CACNG4
uniprot id: A0A2K5VDF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

9541:LOC102125235
gene id: 9541:LOC102125235
uniprot id: A0A2K5VGG3
names: Similarity
messages: Belongs to the SPAN-X family.

9541:ARRDC3
gene id: 9541:ARRDC3
uniprot id: A0A2K5UXR4
uniprot id: A0A8J8YAC8
names: Similarity
messages: Belongs to the arrestin family.

9541:SIVA1
gene id: 9541:SIVA1
uniprot id: A0A2K5UBT5
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

9541:CUL7
gene id: 9541:CUL7
uniprot id: A0A2K5WSN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9541:GNPDA2
gene id: 9541:GNPDA2
uniprot id: A0A8J8YT43
uniprot id: G7P5I3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9541:SLC4A10
gene id: 9541:SLC4A10
uniprot id: A0A2K5WSS1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9541:DRAM1
gene id: 9541:DRAM1
uniprot id: A0A2K5W012
names: Subcellular Location Annotation
messages: Membrane

9541:C8B
gene id: 9541:C8B
uniprot id: A0A2K5TJ42
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:FAAH2
gene id: 9541:FAAH2
uniprot id: A0A8J8YRN5
uniprot id: G7Q2V7
names: Similarity
messages: Belongs to the amidase family.

9541:TFDP1
gene id: 9541:TFDP1
uniprot id: A0A2K5V9M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9541:CFL2
gene id: 9541:CFL2
uniprot id: A0A8J8YPP2
uniprot id: G7PA25
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9541:ALDH18A1
gene id: 9541:ALDH18A1
uniprot id: A0A2K5U7W0
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9541:MARK1
gene id: 9541:MARK1
uniprot id: A0A2K5X332
uniprot id: A0A2K5X387
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9541:IKBKE
gene id: 9541:IKBKE
uniprot id: A0A2K5W1S9
names: Subcellular Location Annotation
messages: Cytoplasm

9541:CTPS1
gene id: 9541:CTPS1
uniprot id: A0A2K5X3G0
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9541:JRKL
gene id: 9541:JRKL
uniprot id: A0A8J8XV97
uniprot id: G7PNI8
names: Subcellular Location Annotation
messages: Nucleus

9541:ENO2
gene id: 9541:ENO2
uniprot id: A0A2K5WDD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9541:SLC2A7
gene id: 9541:SLC2A7
uniprot id: A0A2K5WT05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane

9541:SPOUT1
gene id: 9541:SPOUT1
uniprot id: A0A2K5UGR3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

9541:SLC12A6
gene id: 9541:SLC12A6
uniprot id: A0A2K5UGV2
uniprot id: A0A2K5UH02
uniprot id: A0A8J8Y5I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9541:PDE10A
gene id: 9541:PDE10A
uniprot id: A0A2K5WS86
uniprot id: A0A2K5WSA7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:ATG5
gene id: 9541:ATG5
uniprot id: A0A2K5WVV4
uniprot id: A0A2K5WW04
uniprot id: A0A8J8Y5J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9541:GALNT11
gene id: 9541:GALNT11
uniprot id: A0A2K5VQW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:CHRNA3
gene id: 9541:CHRNA3
uniprot id: A0A2K5TZM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:LOC102126587
gene id: 9541:LOC102126587
uniprot id: A0A2K5TJ91
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9541:NPPC
gene id: 9541:NPPC
uniprot id: A0A2K5WT12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9541:KPNA5
gene id: 9541:KPNA5
uniprot id: A0A2K5TMW1
uniprot id: A0A2K5TMX7
uniprot id: A0A7N9CCA9
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9541:KHDC4
gene id: 9541:KHDC4
uniprot id: A0A8J8XYR8
uniprot id: G7NV70
names: Similarity
messages: Belongs to the KHDC4 family.

9541:LOC102132235
gene id: 9541:LOC102132235
uniprot id: G7PVY6
uniprot id: Q2PG08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Homotrimer. Interacts with LTC4S and ALOX5 (By similarity).
messages: Membrane
messages: Nucleus membrane
messages: Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity).
messages: The C-terminal part after residue 140 is mostly disordered.

9541:ST6GAL1
gene id: 9541:ST6GAL1
uniprot id: A0A7N9CJR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:UBE3A
gene id: 9541:UBE3A
uniprot id: A0A2K5TLG4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9541:MAPK14
gene id: 9541:MAPK14
uniprot id: A0A2K5WJV8
uniprot id: A0A2K5WJW8
uniprot id: A0A8J8Y992
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9541:ABCB9
gene id: 9541:ABCB9
uniprot id: A0A2K5U078
uniprot id: G8F535
names: Subcellular Location Annotation
messages: Membrane

9541:CSTA
gene id: 9541:CSTA
uniprot id: A0A8J8Y6Z8
uniprot id: G7NXR6
names: Similarity
messages: Belongs to the cystatin family.

9541:LOC102136728
gene id: 9541:LOC102136728
uniprot id: A0A2K5TN42
names: Similarity
messages: Belongs to the KHDC1 family.

9541:SNX11
gene id: 9541:SNX11
uniprot id: A0A8J8XAR5
uniprot id: G7PU67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9541:LIN28B
gene id: 9541:LIN28B
uniprot id: A0A7N9ICV0
names: Similarity
messages: Belongs to the lin-28 family.

9541:BCL2A1
gene id: 9541:BCL2A1
uniprot id: A0A2K5TMD8
names: Similarity
messages: Belongs to the Bcl-2 family.

9541:RPS27L
gene id: 9541:RPS27L
uniprot id: A0A2K5X425
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9541:PRL
gene id: 9541:PRL
uniprot id: G7P4J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9541:RPL39L
gene id: 9541:RPL39L
uniprot id: A0A2K5UF67
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9541:GMPPA
gene id: 9541:GMPPA
uniprot id: A0A2K5VWY8
uniprot id: G7PK50
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9541:LOC102142787
gene id: 9541:LOC102142787
uniprot id: Q2PFP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9541:VDAC2
gene id: 9541:VDAC2
uniprot id: A0A7N9CYU8
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9541:CFAP45
gene id: 9541:CFAP45
uniprot id: Q4R8K2
names: Similarity
messages: Belongs to the CFAP45 family.

9541:PTPRT
gene id: 9541:PTPRT
uniprot id: A0A2K5U0K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9541:TUBA1A
gene id: 9541:TUBA1A
uniprot id: I7G2D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9541:GPR141
gene id: 9541:GPR141
uniprot id: A0A7N9DDA8
uniprot id: A0A8J8XWZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:STMN4
gene id: 9541:STMN4
uniprot id: A0A2K5V041
uniprot id: A0A2K5V083
uniprot id: A0A7N9CHI2
names: Similarity
messages: Belongs to the stathmin family.

9541:FUZ
gene id: 9541:FUZ
uniprot id: A0A2K5W9A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

9541:PABIR2
gene id: 9541:PABIR2
uniprot id: A0A7N9CUL9
uniprot id: A0A7N9D5Q1
uniprot id: G7Q1R0
names: Similarity
messages: Belongs to the FAM122 family.

9541:DPAGT1
gene id: 9541:DPAGT1
uniprot id: A0A8J8Y1S0
uniprot id: G7PPA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:MS4A3
gene id: 9541:MS4A3
uniprot id: A0A2K5WXS6
names: Similarity
messages: Belongs to the MS4A family.

9541:BCL9
gene id: 9541:BCL9
uniprot id: A0A2K5VHY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9541:CPSF4
gene id: 9541:CPSF4
uniprot id: A0A8J8Y521
uniprot id: G7P0A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

9541:OSTN
gene id: 9541:OSTN
uniprot id: G7NYP9
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Osteocrin family.
messages: Expression is induced by neuronal activity in the developing cerebral cortex: expression is driven by the presence of a enhancer sequence only present in primates that binds the MEF2 transcription factors (PubMed:27830782).
messages: Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience. Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (By similarity). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).
messages: Interacts with NPR3.
messages: Secreted
messages: This protein-coding gene has been repurposed in primates, with the presence of a new enhancer sequence that drives expression in brain in response to sensory experience, leading to restrict dendritic growth in the developing cortex (PubMed:27830782).

9541:FZD2
gene id: 9541:FZD2
uniprot id: A0A2K5WLJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:HHATL
gene id: 9541:HHATL
uniprot id: A0A8J8YIJ7
uniprot id: G7NY66
names: Subcellular Location Annotation
messages: Membrane

9541:METAP1
gene id: 9541:METAP1
uniprot id: A0A2K5VW41
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9541:OXER1
gene id: 9541:OXER1
uniprot id: A0A2K5UQ10
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:MPP7
gene id: 9541:MPP7
uniprot id: A0A2K5VQA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9541:ZNF383
gene id: 9541:ZNF383
uniprot id: Q4R6C2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.
messages: Nucleus
messages: The KRAB domain is responsible for the transcriptional repressor activity.

9541:LOC102146935
gene id: 9541:LOC102146935
uniprot id: A0A2K5WHJ6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:LOC102146005
gene id: 9541:LOC102146005
uniprot id: A0A2K5TMQ0
uniprot id: Q4R5L7
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

9541:SLC37A2
gene id: 9541:SLC37A2
uniprot id: A0A2K5TYE4
uniprot id: A0A2K5TYF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9541:ZNF706
gene id: 9541:ZNF706
uniprot id: A0A2K5VS81
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:PIM1
gene id: 9541:PIM1
uniprot id: A0A2K5W2N0
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9541:CRISP3
gene id: 9541:CRISP3
uniprot id: A0A2K5W4E5
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:USP9X
gene id: 9541:USP9X
uniprot id: A0A2K5V070
names: Similarity
messages: Belongs to the peptidase C19 family.

9541:FAH
gene id: 9541:FAH
uniprot id: A0A2K5U3A1
names: Similarity
messages: Belongs to the FAH family.

9541:PTAR1
gene id: 9541:PTAR1
uniprot id: A0A2K5U4L5
uniprot id: A0A2K5U4M3
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9541:LOC102133057
gene id: 9541:LOC102133057
uniprot id: A0A2K5UN81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9541:LOC102116269
gene id: 9541:LOC102116269
uniprot id: A0A8J8YET7
uniprot id: G7PMI1
names: Similarity
messages: Belongs to the peptidase M67C family.

9541:B3GALNT2
gene id: 9541:B3GALNT2
uniprot id: A0A2K5U945
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:DOCK11
gene id: 9541:DOCK11
uniprot id: A0A2K5X856
names: Similarity
messages: Belongs to the DOCK family.

9541:ATP5PB
gene id: 9541:ATP5PB
uniprot id: A0A2K5TRC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9541:HACD4
gene id: 9541:HACD4
uniprot id: A0A2K5V8W6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:SLC35F6
gene id: 9541:SLC35F6
uniprot id: A0A8J8Y2N0
uniprot id: G7PLU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9541:SLC15A2
gene id: 9541:SLC15A2
uniprot id: A0A2K5V056
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9541:WNT1
gene id: 9541:WNT1
uniprot id: A0A8J8XZH3
uniprot id: G7PHR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:CEP43
gene id: 9541:CEP43
uniprot id: A0A2K5X0K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9541:LOC102133455
gene id: 9541:LOC102133455
uniprot id: A0A7N9CRV9
names: Similarity
messages: Belongs to the LCE family.

9541:IMMP2L
gene id: 9541:IMMP2L
uniprot id: A0A2K5X380
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

9541:ARFGEF2
gene id: 9541:ARFGEF2
uniprot id: A0A2K5TVR7
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9541:KITLG
gene id: 9541:KITLG
uniprot id: A0A7N9CAX5
uniprot id: A0A7N9DG76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

9541:DOP1A
gene id: 9541:DOP1A
uniprot id: A0A2K5V0M3
uniprot id: A0A2K5V0S2
names: Similarity
messages: Belongs to the dopey family.

9541:ITM2B
gene id: 9541:ITM2B
uniprot id: Q60HC1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ITM2 family.
messages: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.
messages: Cell membrane
messages: Endosome membrane
messages: Glycosylation at Asn-170 is important for cell surface localization, but doesn't affect furin- and ADAM10-induced proteolytic processing.
messages: Golgi apparatus membrane
messages: Homodimer; disulfide-linked. Interacts with SPPL2A and SPPL2B. Interacts with APP. Mature BRI2 (mBRI2) interacts with the APP amyloid-beta A4 protein; the interaction occurs at the cell surface and in the endocytic compartments and enable alpha- and beta-secretase-induced APP cleavage inhibition. Mature BRI2 (mBRI2) interacts with the APP C99; the interaction occurs in the endocytic compartments and enable gamma-secretase-induced C99 cleavage inhibition. May form heterodimers with Bri23 peptide and APP amyloid-beta protein 40 (By similarity). Interacts with ADAM7 in sperm; the interaction increases following capacitation (By similarity).
messages: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.
messages: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity).
messages: Secreted
messages: The ectodomain C-terminal part of the imBRI2 is processed by furin producing a secreted Bri23 peptide and a mature BRI2, membrane form (mBRI2). The remaining part of the ectodomain of mBRI2 containing the BRICHOS domain is cleaved by ADAM10 and is secreted (BRI2C, soluble form). The membrane-bound N-terminal fragment (BRI2C, membrane form) is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted C-peptide and a BRI2 intracellular domain (BRI2 ICD) released in the cytosol. Shedding by ADAM10 facilitates intramembrane cleavage but is not absolutely required for BRI2 ICD generation (By similarity).

9541:EXOSC7
gene id: 9541:EXOSC7
uniprot id: A0A8J8XTH2
uniprot id: G7NY47
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SMIM15
gene id: 9541:SMIM15
uniprot id: A0A8J8XQD8
uniprot id: G7P7K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9541:LOC102125892
gene id: 9541:LOC102125892
uniprot id: A0A2K5X1X0
names: Similarity
messages: Belongs to the COX20 family.

9541:SPTLC3
gene id: 9541:SPTLC3
uniprot id: A0A2K5VQA1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9541:SLC39A12
gene id: 9541:SLC39A12
uniprot id: A0A2K5TNC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9541:KCNJ3
gene id: 9541:KCNJ3
uniprot id: A0A2K5VD51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9541:RPL23A
gene id: 9541:RPL23A
uniprot id: A0A2K5UIT1
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9541:SMARCAD1
gene id: 9541:SMARCAD1
uniprot id: A0A2K5W1P6
names: Subcellular Location Annotation
messages: Chromosome

9541:LOC102138227
gene id: 9541:LOC102138227
uniprot id: M9ZR32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9541:SEMA3B
gene id: 9541:SEMA3B
uniprot id: A0A2K5VF98
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LRRC8B
gene id: 9541:LRRC8B
uniprot id: A0A2K5UKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9541:ABCB1
gene id: 9541:ABCB1
uniprot id: Q8HZQ6
names: Subcellular Location Annotation
messages: Membrane

9541:ADM
gene id: 9541:ADM
uniprot id: A0A2K5TTY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

9541:CXCR5
gene id: 9541:CXCR5
uniprot id: A0A2K5WP76
uniprot id: G8F5K4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:VPS29
gene id: 9541:VPS29
uniprot id: A0A2K5U0Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9541:CD53
gene id: 9541:CD53
uniprot id: A0A2K5W6N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:TENT5C
gene id: 9541:TENT5C
uniprot id: A0A7N9D571
uniprot id: A0A8J8Y3K3
names: Similarity
messages: Belongs to the TENT family.

9541:ATG13
gene id: 9541:ATG13
uniprot id: A0A2K5TRZ8
uniprot id: A0A2K5TS08
uniprot id: A0A7N9I9D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9541:PSME4
gene id: 9541:PSME4
uniprot id: A0A2K5WB62
uniprot id: A0A2K5WBG2
names: Similarity
messages: Belongs to the BLM10 family.

9541:PLPPR2
gene id: 9541:PLPPR2
uniprot id: G7PZE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9541:DCST1
gene id: 9541:DCST1
uniprot id: A0A2K5V0Q0
names: Subcellular Location Annotation
messages: Membrane

9541:SOD2
gene id: 9541:SOD2
uniprot id: Q8HXP3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
messages: Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.

9541:CUL4B
gene id: 9541:CUL4B
uniprot id: A0A2K5W089
names: Similarity
messages: Belongs to the cullin family.

9541:LOC102141871
gene id: 9541:LOC102141871
uniprot id: A0A2K5UN08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PIK3R1
gene id: 9541:PIK3R1
uniprot id: A0A7N9CL43
uniprot id: A0A7N9CVN4
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9541:RPS6KA1
gene id: 9541:RPS6KA1
uniprot id: A0A2K5VR69
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9541:RAD1
gene id: 9541:RAD1
uniprot id: A0A7N9D9C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9541:PVALB
gene id: 9541:PVALB
uniprot id: A0A2K5VH89
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9541:LOC102141029
gene id: 9541:LOC102141029
uniprot id: A0A2K5UG77
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9541:VSIG1
gene id: 9541:VSIG1
uniprot id: A0A2K5ULF2
uniprot id: A0A8J8YS04
uniprot id: G7Q3F3
names: Subcellular Location Annotation
messages: Membrane

9541:HTR2B
gene id: 9541:HTR2B
uniprot id: A0A2K5WA17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9541:KCNK13
gene id: 9541:KCNK13
uniprot id: A0A8J8XPH6
uniprot id: G7PB58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9541:LOC101925710
gene id: 9541:LOC101925710
uniprot id: A0A8J8XMW9
uniprot id: G7NZK0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9541:TIMM10
gene id: 9541:TIMM10
uniprot id: A0A2K5U0Z3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9541:UGT8
gene id: 9541:UGT8
uniprot id: A0A8J8XN91
uniprot id: G7P652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9541:IL10
gene id: 9541:IL10
uniprot id: A0A8J8YH31
uniprot id: G7NVB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9541:PRIMPOL
gene id: 9541:PRIMPOL
uniprot id: A0A2K5X7L5
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9541:CLEC16A
gene id: 9541:CLEC16A
uniprot id: A0A2K5TX46
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9541:FAM102B
gene id: 9541:FAM102B
uniprot id: A0A2K5X5M4
uniprot id: G8F4J1
names: Similarity
messages: Belongs to the EEIG family.

9541:EIF4E
gene id: 9541:EIF4E
uniprot id: A0A2K5WU58
uniprot id: I7GAS4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9541:ISL1
gene id: 9541:ISL1
uniprot id: A0A2K5VBK8
names: Subcellular Location Annotation
messages: Nucleus

9541:SLC35B4
gene id: 9541:SLC35B4
uniprot id: Q95KB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar. May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics.
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Endoplasmic reticulum membrane

9541:SPP1
gene id: 9541:SPP1
uniprot id: A0A2K5WL74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

9541:TRAF4
gene id: 9541:TRAF4
uniprot id: A0A2K5W360
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9541:CD47
gene id: 9541:CD47
uniprot id: A0A2K5X4H8
uniprot id: A0A2K5X523
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:CLU
gene id: 9541:CLU
uniprot id: A0A2K5VV75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Microsome
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9541:LHX9
gene id: 9541:LHX9
uniprot id: A0A2K5TRT2
names: Subcellular Location Annotation
messages: Nucleus

9541:ACTR3B
gene id: 9541:ACTR3B
uniprot id: A0A2K5WHL6
names: Similarity
messages: Belongs to the actin family.

9541:CFTR
gene id: 9541:CFTR
uniprot id: A0A2K5U4G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
messages: Membrane
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.
messages: Recycling endosome membrane

9541:IL18
gene id: 9541:IL18
uniprot id: A0A2K5TJ84
uniprot id: A0A2K5TJ87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted

9541:CSTF2
gene id: 9541:CSTF2
uniprot id: A0A2K5VIP5
names: Subcellular Location Annotation
messages: Nucleus

9541:FAM98A
gene id: 9541:FAM98A
uniprot id: A0A2K5UTV3
names: Similarity
messages: Belongs to the FAM98 family.

9541:SERP1
gene id: 9541:SERP1
uniprot id: A0A2K5VW09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9541:SRP19
gene id: 9541:SRP19
uniprot id: A0A2K5TPZ7
uniprot id: A0A7N9CAU8
uniprot id: G8F2L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9541:FABP6
gene id: 9541:FABP6
uniprot id: A0A2K5TX64
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:ARHGEF7
gene id: 9541:ARHGEF7
uniprot id: A0A2K5W795
uniprot id: A0A2K5W7F8
names: Subcellular Location Annotation
messages: lamellipodium

9541:BORCS8
gene id: 9541:BORCS8
uniprot id: A0A2K5V483
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9541:LOC102131403
gene id: 9541:LOC102131403
uniprot id: A0A7N9CW39
names: Similarity
messages: Belongs to the SNF7 family.

9541:GRK1
gene id: 9541:GRK1
uniprot id: A0A2K5WYY3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9541:CYP26B1
gene id: 9541:CYP26B1
uniprot id: A0A7N9IG73
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:GRK7
gene id: 9541:GRK7
uniprot id: A0A2K5TV47
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9541:TSN
gene id: 9541:TSN
uniprot id: A0A2K5VL45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9541:LOC102122319
gene id: 9541:LOC102122319
uniprot id: Q4W8A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Expressed (at protein level) in the kidney.
messages: Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient. Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:15846473). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:15846473) (By similarity). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (By similarity). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule. Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside. May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (PubMed:15846473) (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-convertin…

9541:RHBDL2
gene id: 9541:RHBDL2
uniprot id: A0A2K5V670
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9541:HGF
gene id: 9541:HGF
uniprot id: C9E9X6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9541:CEP70
gene id: 9541:CEP70
uniprot id: A0A2K5TLP6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

9541:HBE1
gene id: 9541:HBE1
uniprot id: A0A2K5WIW1
names: Similarity
messages: Belongs to the globin family.

9541:IFI27
gene id: 9541:IFI27
uniprot id: A0A2K5W5W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9541:GNAT1
gene id: 9541:GNAT1
uniprot id: A0A8J8XU61
uniprot id: G7NXT3
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9541:TM9SF1
gene id: 9541:TM9SF1
uniprot id: A0A8J8XJG6
uniprot id: G7P9Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9541:CDC45
gene id: 9541:CDC45
uniprot id: A0A2K5WQS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9541:ING4
gene id: 9541:ING4
uniprot id: A0A2K5U7V5
uniprot id: G8F3S4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9541:HNRNPR
gene id: 9541:HNRNPR
uniprot id: A0A2K5WY29
names: Subcellular Location Annotation
messages: Cytoplasm

9541:AGTR1
gene id: 9541:AGTR1
uniprot id: G7NZZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

9541:SCML2
gene id: 9541:SCML2
uniprot id: A0A2K5W0N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9541:PTAFR
gene id: 9541:PTAFR
uniprot id: A0A2K5UPJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9541:KCTD21
gene id: 9541:KCTD21
uniprot id: A0A7N9CEL6
uniprot id: A0A8J8XEA7
names: Subcellular Location Annotation
messages: Cell membrane

9541:IFNAR1
gene id: 9541:IFNAR1
uniprot id: A0A2K5VGY1
uniprot id: A0A7N9D7J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9541:EFNB2
gene id: 9541:EFNB2
uniprot id: A0A2K5TNA1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:MFAP2
gene id: 9541:MFAP2
uniprot id: A0A2K5WR60
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:CDK9
gene id: 9541:CDK9
uniprot id: A0A2K5WDZ1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:LOC102128774
gene id: 9541:LOC102128774
uniprot id: G7P6U9
uniprot id: Q76KA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL32 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9541:SCRN1
gene id: 9541:SCRN1
uniprot id: A0A2K5W4I0
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9541:EBF3
gene id: 9541:EBF3
uniprot id: A0A2K5U465
uniprot id: A0A2K5U4D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9541:KPNA7
gene id: 9541:KPNA7
uniprot id: A0A2K5UXA0
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9541:SEPTIN11
gene id: 9541:SEPTIN11
uniprot id: A0A2K5VXY1
uniprot id: A0A2K5VY70
uniprot id: A0A7N9D789
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:LOC102125690
gene id: 9541:LOC102125690
uniprot id: A0A2K5VWL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

9541:SGF29
gene id: 9541:SGF29
uniprot id: A0A2K5WKH8
names: Subcellular Location Annotation
messages: Nucleus

9541:ATP5IF1
gene id: 9541:ATP5IF1
uniprot id: A0A8J8YQQ0
uniprot id: G7NWV6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9541:LRRC8D
gene id: 9541:LRRC8D
uniprot id: A0A7N9CFD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9541:SRRD
gene id: 9541:SRRD
uniprot id: A0A2K5V8Y7
names: Similarity
messages: Belongs to the SRR1 family.

9541:DNAJA2
gene id: 9541:DNAJA2
uniprot id: I7GPI6
names: Subcellular Location Annotation
messages: Membrane

9541:TMEM14C
gene id: 9541:TMEM14C
uniprot id: A0A2K5VEW3
names: Similarity
messages: Belongs to the TMEM14 family.

9541:CORO6
gene id: 9541:CORO6
uniprot id: A0A2K5VD52
names: Similarity
messages: Belongs to the WD repeat coronin family.

9541:MUL1
gene id: 9541:MUL1
uniprot id: A0A2K5WGR6
names: Subcellular Location Annotation
messages: Membrane

9541:EXOSC4
gene id: 9541:EXOSC4
uniprot id: A0A2K5U584
names: Subcellular Location Annotation
messages: Cytoplasm

9541:BMPR1B
gene id: 9541:BMPR1B
uniprot id: A0A2K5W4R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:STC1
gene id: 9541:STC1
uniprot id: A0A2K5X7H0
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9541:FAM166A
gene id: 9541:FAM166A
uniprot id: A0A2K5U1M7
names: Similarity
messages: Belongs to the CIMIP2 family.

9541:NPR2
gene id: 9541:NPR2
uniprot id: A0A2K5WQF7
uniprot id: A0A2K5WQM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9541:KRT5
gene id: 9541:KRT5
uniprot id: A0A2K5WMJ9
names: Similarity
messages: Belongs to the intermediate filament family.

9541:PRKCQ
gene id: 9541:PRKCQ
uniprot id: A0A2K5WLP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9541:CLRN3
gene id: 9541:CLRN3
uniprot id: A0A8J8YJZ2
uniprot id: G7PEC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9541:CNIH4
gene id: 9541:CNIH4
uniprot id: A0A8J8YII1
uniprot id: G7NTW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9541:CRY2
gene id: 9541:CRY2
uniprot id: G7PQC1
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

9541:PATL1
gene id: 9541:PATL1
uniprot id: A0A2K5WQ26
uniprot id: A0A2K5WQH7
names: Similarity
messages: Belongs to the PAT1 family.

9541:LRRC42
gene id: 9541:LRRC42
uniprot id: A0A7N9IFT9
names: Similarity
messages: Belongs to the LRRC42 family.

9541:S100A5
gene id: 9541:S100A5
uniprot id: A0A2K5WRQ8
names: Similarity
messages: Belongs to the S-100 family.

9541:ATP6V1B1
gene id: 9541:ATP6V1B1
uniprot id: A0A8J8XV71
uniprot id: G7PMF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9541:UCP2
gene id: 9541:UCP2
uniprot id: A0A8J8YLM4
uniprot id: G7PN78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:CZIB
gene id: 9541:CZIB
uniprot id: A0A2K5U234
names: Similarity
messages: Belongs to the UPF0587 family.

9541:NAA60
gene id: 9541:NAA60
uniprot id: I7GHY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

9541:RBM8A
gene id: 9541:RBM8A
uniprot id: A0A8J8YI94
uniprot id: G7NTP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9541:SPDEF
gene id: 9541:SPDEF
uniprot id: A0A8J8XPV0
uniprot id: G7P2U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:BBS2
gene id: 9541:BBS2
uniprot id: A0A2K5V5J4
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9541:GGA1
gene id: 9541:GGA1
uniprot id: A0A2K5VLX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9541:SLC51A
gene id: 9541:SLC51A
uniprot id: A0A7N9DE93
names: Subcellular Location Annotation
messages: Membrane

9541:VAX2
gene id: 9541:VAX2
uniprot id: A0A2K5WMN6
names: Subcellular Location Annotation
messages: Nucleus

9541:ZRANB2
gene id: 9541:ZRANB2
uniprot id: A0A2K5W9B9
uniprot id: A0A2K5W9D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9541:CEP57
gene id: 9541:CEP57
uniprot id: A0A2K5WBP1
names: Similarity
messages: Belongs to the translokin family.

9541:VMA21
gene id: 9541:VMA21
uniprot id: A0A2K5TYJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9541:EOMES
gene id: 9541:EOMES
uniprot id: A0A2K5TX18
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:DAD1
gene id: 9541:DAD1
uniprot id: A0A8J8XJ59
uniprot id: G7P9T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9541:PHETA2
gene id: 9541:PHETA2
uniprot id: G7PFP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9541:LAMP2
gene id: 9541:LAMP2
uniprot id: A0A2K5UKF4
uniprot id: A0A8J8YC93
uniprot id: G7Q3L7
uniprot id: Q4R5B5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9541:NXT2
gene id: 9541:NXT2
uniprot id: I7GLF0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9541:PIGH
gene id: 9541:PIGH
uniprot id: A0A2K5TS98
names: Similarity
messages: Belongs to the PIGH family.

9541:IMPDH2
gene id: 9541:IMPDH2
uniprot id: A0A8J8Y817
uniprot id: G7NXU9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9541:MDM1
gene id: 9541:MDM1
uniprot id: A0A2K5VLI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9541:BRIX1
gene id: 9541:BRIX1
uniprot id: A0A8J8XBZ9
uniprot id: G7P7C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9541:POPDC2
gene id: 9541:POPDC2
uniprot id: A0A2K5WX81
uniprot id: A0A2K5WX93
uniprot id: A0A2K5WXT7
names: Similarity
messages: Belongs to the popeye family.

9541:FNTB
gene id: 9541:FNTB
uniprot id: A0A2K5WSQ5
uniprot id: A0A2K5WSS2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.

9541:CNOT7
gene id: 9541:CNOT7
uniprot id: A0A2K5WJS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9541:MBTPS1
gene id: 9541:MBTPS1
uniprot id: A0A2K5V1G2
names: Similarity
messages: Belongs to the peptidase S8 family.

9541:ARHGEF6
gene id: 9541:ARHGEF6
uniprot id: A0A7N9D7C5
uniprot id: A0A8J8XE62
uniprot id: G7Q1T5
names: Subcellular Location Annotation
messages: lamellipodium

9541:PROM2
gene id: 9541:PROM2
uniprot id: A0A2K5VE89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9541:POLR2G
gene id: 9541:POLR2G
uniprot id: A0A2K5U485
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9541:RPL34
gene id: 9541:RPL34
uniprot id: A0A2K5UBG0
uniprot id: A0A2K5UH45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9541:PIGN
gene id: 9541:PIGN
uniprot id: A0A2K5VN51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

9541:SGK2
gene id: 9541:SGK2
uniprot id: A0A2K5V2R8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:NPC2
gene id: 9541:NPC2
uniprot id: P61918
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NPC2 family.
messages: Binds cholesterol in a hydrophobic pocket; there are no hydrogen bonds between the sterol and the protein.
messages: Detected in epididymis.
messages: Endoplasmic reticulum
messages: Interacts with NPC1 (via the second lumenal domain) in a cholestrol-dependent manner. Interacts with NUS1/NgBR, the interaction stabilizes NCP2 and regulates cholesterol trafficking. Interacts with DHDDS. Interacts with NEDD4L (via C2 domain). Interacts with NPC1L1.
messages: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
messages: Lysosome
messages: Secreted

9541:GPR183
gene id: 9541:GPR183
uniprot id: A0A2K5UIV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SMDT1
gene id: 9541:SMDT1
uniprot id: A0A8J8XLW1
uniprot id: G7PFP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9541:LOC102132704
gene id: 9541:LOC102132704
uniprot id: A0A7N9CS21
names: Similarity
messages: Belongs to the LCE family.

9541:MANEA
gene id: 9541:MANEA
uniprot id: A0A8J8YEI5
uniprot id: G7P424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:GNG11
gene id: 9541:GNG11
uniprot id: G7P1D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:NSMCE1
gene id: 9541:NSMCE1
uniprot id: A0A2K5VVU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9541:LOC102120590
gene id: 9541:LOC102120590
uniprot id: A0A2K5VX05
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9541:KRT4
gene id: 9541:KRT4
uniprot id: A0A2K5U9Q7
names: Similarity
messages: Belongs to the intermediate filament family.

9541:TAF12
gene id: 9541:TAF12
uniprot id: A0A2K5WVK9
uniprot id: A0A7N9DG10
uniprot id: G8F4R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9541:PDSS1
gene id: 9541:PDSS1
uniprot id: A0A2K5W1G8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9541:TMED3
gene id: 9541:TMED3
uniprot id: A0A2K5WIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9541:NRG1
gene id: 9541:NRG1
uniprot id: A0A7N9CGF1
uniprot id: A0A7N9DEP1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:FOXP4
gene id: 9541:FOXP4
uniprot id: A0A2K5TJF8
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC107126432
gene id: 9541:LOC107126432
uniprot id: A0A2K5USP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

9541:LOC102124577
gene id: 9541:LOC102124577
uniprot id: A0A2K5UJZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9541:ALDH1L1
gene id: 9541:ALDH1L1
uniprot id: A0A8J8YFN1
uniprot id: G7NYF0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9541:RRS1
gene id: 9541:RRS1
uniprot id: A0A2K5TP91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9541:RTN1
gene id: 9541:RTN1
uniprot id: A0A2K5UVG7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:DAG1
gene id: 9541:DAG1
uniprot id: A0A2K5VM36
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9541:MRPL43
gene id: 9541:MRPL43
uniprot id: A0A2K5W456
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9541:POGLUT3
gene id: 9541:POGLUT3
uniprot id: A0A2K5WVB9
names: Similarity
messages: Belongs to the KDELC family.

9541:SEC23B
gene id: 9541:SEC23B
uniprot id: A0A8J8XJI6
uniprot id: Q9BE95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9541:MED22
gene id: 9541:MED22
uniprot id: A0A8J8YI95
uniprot id: G7PR93
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9541:ATP6V1G2
gene id: 9541:ATP6V1G2
uniprot id: A0A2K5V321
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:TPX2
gene id: 9541:TPX2
uniprot id: A0A2K5VME8
uniprot id: G7PGN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

9541:PCYOX1L
gene id: 9541:PCYOX1L
uniprot id: A0A2K5WXH5
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9541:PCSK1
gene id: 9541:PCSK1
uniprot id: A0A2K5V5J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9541:GEM
gene id: 9541:GEM
uniprot id: A0A8J8YSC9
uniprot id: G7PC82
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9541:NR1H4
gene id: 9541:NR1H4
uniprot id: A0A2K5TYF5
uniprot id: A0A2K5TYG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9541:GCK
gene id: 9541:GCK
uniprot id: A0A2K5VIQ1
names: Similarity
messages: Belongs to the hexokinase family.

9541:KRT2
gene id: 9541:KRT2
uniprot id: G7PID3
names: Similarity
messages: Belongs to the intermediate filament family.

9541:EMC4
gene id: 9541:EMC4
uniprot id: A0A2K5WM52
uniprot id: A0A8J8YRR3
uniprot id: G7PAP1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:CUTC
gene id: 9541:CUTC
uniprot id: A0A8J8XRE7
uniprot id: G7PDQ4
names: Similarity
messages: Belongs to the CutC family.

9541:HEATR5B
gene id: 9541:HEATR5B
uniprot id: A0A2K5V267
uniprot id: A0A8J8XGY1
names: Similarity
messages: Belongs to the HEATR5 family.

9541:AMACR
gene id: 9541:AMACR
uniprot id: A0A2K5V1A6
names: Similarity
messages: Belongs to the CoA-transferase III family.

9541:GPR101
gene id: 9541:GPR101
uniprot id: A0A8J8XDN8
uniprot id: G7Q1T8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:SPRYD4
gene id: 9541:SPRYD4
uniprot id: A0A8J8XDH4
uniprot id: G7PII3
names: Subcellular Location Annotation
messages: Cytoplasm

9541:BBOX1
gene id: 9541:BBOX1
uniprot id: A0A2K5VJL2
names: Function
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

9541:ADORA2A
gene id: 9541:ADORA2A
uniprot id: G7PHD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9541:BLMH
gene id: 9541:BLMH
uniprot id: A0A2K5TUG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

9541:ESRRB
gene id: 9541:ESRRB
uniprot id: A0A7N9IF67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9541:TMEM63B
gene id: 9541:TMEM63B
uniprot id: A0A7N9ICI8
uniprot id: A0A8J8YDD7
uniprot id: G7P403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9541:PDCD4
gene id: 9541:PDCD4
uniprot id: A0A2K5TWN0
names: Similarity
messages: Belongs to the PDCD4 family.

9541:ALKBH2
gene id: 9541:ALKBH2
uniprot id: A0A2K5WAK3
names: Similarity
messages: Belongs to the alkB family.

9541:TLCD4
gene id: 9541:TLCD4
uniprot id: A0A8J8XS27
uniprot id: G7NV14
names: Subcellular Location Annotation
messages: Membrane

9541:S1PR3
gene id: 9541:S1PR3
uniprot id: A0A2K5UC89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:IFI35
gene id: 9541:IFI35
uniprot id: A0A2K5WUP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9541:MRPL22
gene id: 9541:MRPL22
uniprot id: A0A2K5TTD7
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9541:IL33
gene id: 9541:IL33
uniprot id: A0A2K5W3I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9541:NMD3
gene id: 9541:NMD3
uniprot id: A0A7N9DFA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9541:SLC30A2
gene id: 9541:SLC30A2
uniprot id: A0A2K5W895
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9541:TRIQK
gene id: 9541:TRIQK
uniprot id: A0A2K5UNC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:TMEM170B
gene id: 9541:TMEM170B
uniprot id: A0A2K5TPY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9541:PRPSAP1
gene id: 9541:PRPSAP1
uniprot id: A0A7N9DCF7
uniprot id: A0A7N9IDC8
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9541:DARS2
gene id: 9541:DARS2
uniprot id: A0A2K5W7F9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9541:UCK1
gene id: 9541:UCK1
uniprot id: A0A2K5UCT6
names: Similarity
messages: Belongs to the uridine kinase family.

9541:UBXN1
gene id: 9541:UBXN1
uniprot id: A0A2K5VTT1
names: Subcellular Location Annotation
messages: Cytoplasm

9541:MINDY2
gene id: 9541:MINDY2
uniprot id: A0A2K5V6J1
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9541:UFM1
gene id: 9541:UFM1
uniprot id: Q4R4I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UFM1 family.
messages: Cytoplasm
messages: Interacts with UBA5. Interacts with UFC1.
messages: Nucleus
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription.

9541:EXOSC3
gene id: 9541:EXOSC3
uniprot id: A0A2K5TVI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm
messages: nucleolus

9541:CSE1L
gene id: 9541:CSE1L
uniprot id: A0A2K5WF48
uniprot id: A0A8J8YQ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9541:ST8SIA4
gene id: 9541:ST8SIA4
uniprot id: A0A2K5V6P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:LOC102131547
gene id: 9541:LOC102131547
uniprot id: A0A2K5UIB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:KIF15
gene id: 9541:KIF15
uniprot id: A0A2K5WY85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.
messages: spindle

9541:ATP5F1C
gene id: 9541:ATP5F1C
uniprot id: A0A2K5UQ24
uniprot id: A0A8J8YNN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9541:VEZT
gene id: 9541:VEZT
uniprot id: A0A7N9CKC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9541:SEC61B
gene id: 9541:SEC61B
uniprot id: A0A2K5TY58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9541:KAT5
gene id: 9541:KAT5
uniprot id: A0A2K5U8L4
uniprot id: A0A2K5U8P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9541:LOC102144088
gene id: 9541:LOC102144088
uniprot id: A0A7N9CH16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9541:CEP20
gene id: 9541:CEP20
uniprot id: A0A2K5X8V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9541:VDAC3
gene id: 9541:VDAC3
uniprot id: A0A2K5VWZ7
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9541:SNPH
gene id: 9541:SNPH
uniprot id: A0A2K5V0S5
names: Subcellular Location Annotation
messages: Membrane

9541:RBP1
gene id: 9541:RBP1
uniprot id: A0A2K5UXD8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:SERF2
gene id: 9541:SERF2
uniprot id: A0A2K5TR10
names: Similarity
messages: Belongs to the SERF family.

9541:CLDND2
gene id: 9541:CLDND2
uniprot id: A0A2K5WXQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9541:ZEB2
gene id: 9541:ZEB2
uniprot id: A0A2K5URR5
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9541:PDS5B
gene id: 9541:PDS5B
uniprot id: A0A2K5WHF0
uniprot id: A0A2K5WHL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDS5 family.
messages: Nucleus

9541:LOC102116507
gene id: 9541:LOC102116507
uniprot id: A0A2K5UE54
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:YWHAZ
gene id: 9541:YWHAZ
uniprot id: A0A8J8Y9Q2
uniprot id: G7PCF6
names: Similarity
messages: Belongs to the 14-3-3 family.

9541:CNTN1
gene id: 9541:CNTN1
uniprot id: A0A2K5VCR7
uniprot id: A0A2K5VCW8
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9541:UNC5C
gene id: 9541:UNC5C
uniprot id: A0A8J8YQ14
uniprot id: G7P5Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9541:RNMT
gene id: 9541:RNMT
uniprot id: Q4R7K1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.
messages: Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymerase II and RNGTT. Interacts with RAMAC, this interaction significantly enhances RNA-binding and cap methyltransferase activity.
messages: Methyltransferase activity is activated by RAMAC.
messages: Nucleus

9541:RPLP2
gene id: 9541:RPLP2
uniprot id: I7GJM4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9541:ARL1
gene id: 9541:ARL1
uniprot id: A0A7N9CXT6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9541:ISY1
gene id: 9541:ISY1
uniprot id: A0A7N9CWY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9541:LIG3
gene id: 9541:LIG3
uniprot id: A0A2K5VCG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9541:HGD
gene id: 9541:HGD
uniprot id: A0A2K5VXD4
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9541:LOC102144252
gene id: 9541:LOC102144252
uniprot id: A0A2K5W993
uniprot id: A0A2K5W9F1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:MTFR2
gene id: 9541:MTFR2
uniprot id: A0A2K5WNN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9541:WNK3
gene id: 9541:WNK3
uniprot id: A0A2K5UTA2
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9541:TUBB
gene id: 9541:TUBB
uniprot id: A0A2K5WBU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9541:NMNAT3
gene id: 9541:NMNAT3
uniprot id: A0A2K5VKW6
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9541:PPFIA2
gene id: 9541:PPFIA2
uniprot id: A0A2K5UXP8
uniprot id: A0A2K5UXX5
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9541:RAB14
gene id: 9541:RAB14
uniprot id: A0A2K5WS33
uniprot id: A0A8J8XWB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9541:CDKN1A
gene id: 9541:CDKN1A
uniprot id: A0A8J8XAP2
uniprot id: G7P3C1
names: Similarity
messages: Belongs to the CDI family.

9541:CAMK1G
gene id: 9541:CAMK1G
uniprot id: A0A2K5U137
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:MED15
gene id: 9541:MED15
uniprot id: A0A2K5TNG5
uniprot id: A0A2K5TNH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9541:C14H11orf58
gene id: 9541:C14H11orf58
uniprot id: A0A2K5VVN6
uniprot id: A0A8J8YED3
names: Similarity
messages: Belongs to the SMAP family.

9541:KEG98 p03
gene id: 9541:KEG98_p03
uniprot id: C3W4Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9541:DPEP2
gene id: 9541:DPEP2
uniprot id: A0A2K5X8R4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9541:COG8
gene id: 9541:COG8
uniprot id: A0A2K5U545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG8 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:CNR2
gene id: 9541:CNR2
uniprot id: A0A8J8XAP5
uniprot id: G7NVV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PLPPR4
gene id: 9541:PLPPR4
uniprot id: A0A2K5VS40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9541:NEIL3
gene id: 9541:NEIL3
uniprot id: A0A2K5U0A2
names: Similarity
messages: Belongs to the FPG family.

9541:NR2C1
gene id: 9541:NR2C1
uniprot id: G8F430
uniprot id: Q95K90
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C2 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain). Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression (By similarity).
messages: Nucleus
messages: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity).
messages: PML body
messages: Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-220, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity).
messages: Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity).

9541:BAZ1A
gene id: 9541:BAZ1A
uniprot id: A0A2K5VE62
names: Subcellular Location Annotation
messages: Nucleus

9541:SERPINH1
gene id: 9541:SERPINH1
uniprot id: A0A7N9CCH8
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

9541:WNT2
gene id: 9541:WNT2
uniprot id: A0A8J8XZG3
uniprot id: G7P2I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:GMPPB
gene id: 9541:GMPPB
uniprot id: A0A2K5UBH2
uniprot id: G8F4N3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9541:ATR
gene id: 9541:ATR
uniprot id: A0A2K5U8D7
uniprot id: A0A7N9D8L4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.

9541:CORO1A
gene id: 9541:CORO1A
uniprot id: A0A2K5URY2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

9541:RUNDC3B
gene id: 9541:RUNDC3B
uniprot id: A0A2K5TXD1
uniprot id: A0A7N9CLF4
uniprot id: A0A8J8Y7Q4
names: Similarity
names: Subunit
messages: Belongs to the RUNDC3 family.
messages: Interacts with RAP2A.

9541:MMP7
gene id: 9541:MMP7
uniprot id: A0A8J8XW62
uniprot id: G7PNJ9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9541:GRM4
gene id: 9541:GRM4
uniprot id: A0A2K5VGS8
uniprot id: A0A2K5VGV9
uniprot id: A0A2K5VGY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9541:NUDT5
gene id: 9541:NUDT5
uniprot id: A0A7N9CQS9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9541:PDE6A
gene id: 9541:PDE6A
uniprot id: A0A2K5X2J2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:FAM3D
gene id: 9541:FAM3D
uniprot id: A0A7N9CBG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9541:SSBP2
gene id: 9541:SSBP2
uniprot id: A0A2K5VLT6
uniprot id: A0A2K5VLU6
names: Subcellular Location Annotation
messages: Nucleus

9541:SLC13A1
gene id: 9541:SLC13A1
uniprot id: A0A8J8Y2D1
uniprot id: G7P0J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9541:ALG3
gene id: 9541:ALG3
uniprot id: A0A2K5TUN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LONP2
gene id: 9541:LONP2
uniprot id: A0A2K5UNH6
uniprot id: G7Q128
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
messages: Belongs to the peptidase S16 family.
messages: Interacts with PEX5. Interacts with TYSND1.
messages: Peroxisome matrix

9541:NDUFB7
gene id: 9541:NDUFB7
uniprot id: A0A2K5VGE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9541:POLR3D
gene id: 9541:POLR3D
uniprot id: A0A2K5UM89
names: Subcellular Location Annotation
messages: Nucleus

9541:TRIM36
gene id: 9541:TRIM36
uniprot id: A0A2K5VUQ5
uniprot id: A0A7N9DBA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

9541:RXFP1
gene id: 9541:RXFP1
uniprot id: A0A2K5VSE7
uniprot id: A0A2K5VSF6
uniprot id: A0A8J8XFC7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PEX5L
gene id: 9541:PEX5L
uniprot id: A0A2K5W6Y9
uniprot id: A0A2K5W705
uniprot id: A0A2K5W740
uniprot id: A0A8J8YAI2
uniprot id: G7NZ25
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9541:TRIP12
gene id: 9541:TRIP12
uniprot id: A0A2K5W101
uniprot id: A0A7N9CWS4
uniprot id: G7PK88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9541:WARS1
gene id: 9541:WARS1
uniprot id: A0A8J8XZ21
uniprot id: G7PBM3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9541:CAMK2A
gene id: 9541:CAMK2A
uniprot id: A0A2K5VDJ3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9541:GRPEL2
gene id: 9541:GRPEL2
uniprot id: A0A2K5VN42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9541:CASC3
gene id: 9541:CASC3
uniprot id: A0A2K5WWN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

9541:FGF14
gene id: 9541:FGF14
uniprot id: A0A2K5WQR6
uniprot id: A0A7N9CAT2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:BCL7B
gene id: 9541:BCL7B
uniprot id: A0A2K5WN28
names: Similarity
messages: Belongs to the BCL7 family.

9541:MAPKAP1
gene id: 9541:MAPKAP1
uniprot id: A0A2K5V3L0
uniprot id: A0A2K5V3Q6
uniprot id: G8F3Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIN1 family.
messages: Cytoplasmic vesicle

9541:LOC102142266
gene id: 9541:LOC102142266
uniprot id: A0A2K5WGR2
names: Similarity
messages: Belongs to the FAM154 family.

9541:RPL29
gene id: 9541:RPL29
uniprot id: A0A2K5TPR9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9541:CHDH
gene id: 9541:CHDH
uniprot id: A0A2K5U1B5
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

9541:P4HA1
gene id: 9541:P4HA1
uniprot id: A0A2K5USE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9541:TPRKB
gene id: 9541:TPRKB
uniprot id: A0A2K5VHW0
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9541:ELMO1
gene id: 9541:ELMO1
uniprot id: A0A7N9CBV5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9541:ALDH1A3
gene id: 9541:ALDH1A3
uniprot id: A0A2K5VVJ1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:PRKAB2
gene id: 9541:PRKAB2
uniprot id: A0A2K5X0G4
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9541:CD63
gene id: 9541:CD63
uniprot id: A0A2K5TKQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9541:TNFAIP6
gene id: 9541:TNFAIP6
uniprot id: A0A8J8XIV1
uniprot id: G7PKK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:KEG98 p02
gene id: 9541:KEG98_p02
uniprot id: C3W4Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9541:AIDA
gene id: 9541:AIDA
uniprot id: A0A7N9CRW4
names: Similarity
messages: Belongs to the AIDA family.

9541:LPAR2
gene id: 9541:LPAR2
uniprot id: A0A2K5TSP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LOC102134263
gene id: 9541:LOC102134263
uniprot id: A0A2K5VDT1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

9541:MDM2
gene id: 9541:MDM2
uniprot id: A0A2K5W2P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9541:MIGA1
gene id: 9541:MIGA1
uniprot id: A0A7N9CBP6
names: Similarity
messages: Belongs to the mitoguardin family.

9541:PARG
gene id: 9541:PARG
uniprot id: A0A2K5VGN9
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9541:PSMB2
gene id: 9541:PSMB2
uniprot id: A0A7N9DA15
uniprot id: A0A8J8XJ00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9541:TNFSF11
gene id: 9541:TNFSF11
uniprot id: A0A2K5V2X5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9541:FGF6
gene id: 9541:FGF6
uniprot id: A0A2K5U9Z0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:LOC102114868
gene id: 9541:LOC102114868
uniprot id: A0A2K5W5C2
names: Subcellular Location Annotation
messages: Secreted

9541:NFX1
gene id: 9541:NFX1
uniprot id: A0A7N9CVF7
names: Similarity
messages: Belongs to the NFX1 family.

9541:TBX5
gene id: 9541:TBX5
uniprot id: A0A2K5VPI4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:ST7
gene id: 9541:ST7
uniprot id: A0A2K5ULV5
uniprot id: Q2PG42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9541:EHD4
gene id: 9541:EHD4
uniprot id: A0A7N9DAY1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9541:ATP5PD
gene id: 9541:ATP5PD
uniprot id: A0A2K5U1U7
uniprot id: A0A2K5U1V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9541:ZKSCAN2
gene id: 9541:ZKSCAN2
uniprot id: A0A2K5WPZ5
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:CMTM8
gene id: 9541:CMTM8
uniprot id: A0A2K5UTJ6
names: Subcellular Location Annotation
messages: Membrane

9541:SPSB1
gene id: 9541:SPSB1
uniprot id: A0A8J8Y8G1
uniprot id: G7NTE0
names: Similarity
messages: Belongs to the SPSB family.

9541:CCT7
gene id: 9541:CCT7
uniprot id: A0A2K5X2V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9541:EFTUD2
gene id: 9541:EFTUD2
uniprot id: A0A2K5W206
names: Subcellular Location Annotation
messages: Nucleus

9541:MRPL17
gene id: 9541:MRPL17
uniprot id: A0A7N9CCT5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9541:B3GAT3
gene id: 9541:B3GAT3
uniprot id: A0A2K5U5G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:NTAQ1
gene id: 9541:NTAQ1
uniprot id: A0A2K5VRW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9541:ELK1
gene id: 9541:ELK1
uniprot id: I7G4D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:SV2A
gene id: 9541:SV2A
uniprot id: A0A2K5WGW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9541:PDIA4
gene id: 9541:PDIA4
uniprot id: A0A2K5WKB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Part of a large chaperone multiprotein complex.

9541:ST6GALNAC3
gene id: 9541:ST6GALNAC3
uniprot id: A0A2K5TS30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:MPPED2
gene id: 9541:MPPED2
uniprot id: A0A8J8YKL0
uniprot id: G7PQH5
names: Similarity
messages: Belongs to the UPF0046 family.

9541:SMUG1
gene id: 9541:SMUG1
uniprot id: A0A2K5WLY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9541:CDKN1B
gene id: 9541:CDKN1B
uniprot id: A0A2K5V146
uniprot id: G7PJW2
names: Similarity
messages: Belongs to the CDI family.

9541:ZSCAN25
gene id: 9541:ZSCAN25
uniprot id: A0A7N9IAK5
names: Subcellular Location Annotation
messages: Nucleus

9541:ASB6
gene id: 9541:ASB6
uniprot id: A0A2K5UDT3
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:LHX6
gene id: 9541:LHX6
uniprot id: A0A2K5VM87
uniprot id: A0A2K5VMC6
names: Subcellular Location Annotation
messages: Nucleus

9541:ATP9B
gene id: 9541:ATP9B
uniprot id: A0A2K5VBZ6
uniprot id: A0A2K5VC06
uniprot id: A0A7N9CZH0
uniprot id: A0A7N9D7E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9541:RAB27B
gene id: 9541:RAB27B
uniprot id: A0A8J8YNG2
uniprot id: G7PWU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9541:P2RX3
gene id: 9541:P2RX3
uniprot id: A0A8J8XY24
uniprot id: G7PQ42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9541:DGAT2L6
gene id: 9541:DGAT2L6
uniprot id: A0A2K5X0C2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:OPTN
gene id: 9541:OPTN
uniprot id: Q95KA2
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.
messages: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
messages: Recycling endosome
messages: Self-associates (By similarity). Interacts with HD, GTF3A, TRAF3, TBK1 and MYO6. Interacts (via UBAN) with ubiquitinated TFRC. Interacts with active GTP-bound Rab8 (RAB8A and/or RAB8B). Interacts with TBC1D17. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increases the association (at least with MAP1LC3B). Interacts with RAB12; the interaction may be indirect (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction does not lead to palmitoylation of OPTN (By similarity). Interacts with CYLD (By similarity). Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and OPTN (By similarity).
messages: The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.
messages: Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9541:LOC101866861
gene id: 9541:LOC101866861
uniprot id: A0A2K5VHV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9541:TMEM184C
gene id: 9541:TMEM184C
uniprot id: A0A2K5U2Y7
names: Subcellular Location Annotation
messages: Membrane

9541:EIF2S2
gene id: 9541:EIF2S2
uniprot id: Q4R5G5
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9541:FAM118B
gene id: 9541:FAM118B
uniprot id: A0A7N9CHQ2
uniprot id: A0A805R453
names: Similarity
messages: Belongs to the FAM118 family.

9541:DEFB128
gene id: 9541:DEFB128
uniprot id: A4H255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:USP39
gene id: 9541:USP39
uniprot id: A0A2K5WUF9
names: Subcellular Location Annotation
messages: Nucleus

9541:FAM167B
gene id: 9541:FAM167B
uniprot id: A0A2K5TR07
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9541:XPO6
gene id: 9541:XPO6
uniprot id: A0A2K5VRV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9541:CLP1
gene id: 9541:CLP1
uniprot id: G7PQ31
uniprot id: Q4R7R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).

9541:SUSD3
gene id: 9541:SUSD3
uniprot id: A0A2K5VGW4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RIC3
gene id: 9541:RIC3
uniprot id: G7PQS9
names: Similarity
messages: Belongs to the ric-3 family.

9541:YIPF1
gene id: 9541:YIPF1
uniprot id: A0A2K5TMJ1
uniprot id: A0A8J8YRQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9541:GAREM1
gene id: 9541:GAREM1
uniprot id: A0A2K5X4S9
names: Similarity
messages: Belongs to the GAREM family.

9541:CLCN6
gene id: 9541:CLCN6
uniprot id: A0A2K5U8D9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:MAP2K3
gene id: 9541:MAP2K3
uniprot id: A0A2K5WJP6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:GJB2
gene id: 9541:GJB2
uniprot id: A0A2K5UFL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:MTIF3
gene id: 9541:MTIF3
uniprot id: A0A2K5VR16
names: Similarity
messages: Belongs to the IF-3 family.

9541:CGA
gene id: 9541:CGA
uniprot id: G7P3J5
uniprot id: Q9BEH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9541:ADIPOR2
gene id: 9541:ADIPOR2
uniprot id: A0A2K5TJQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:THYN1
gene id: 9541:THYN1
uniprot id: A0A2K5X461
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9541:HOXD10
gene id: 9541:HOXD10
uniprot id: A0A2K5UTS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9541:LOC102130773
gene id: 9541:LOC102130773
uniprot id: A0A8J8YM65
uniprot id: G7PZT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9541:OTX1
gene id: 9541:OTX1
uniprot id: A0A8J8YA87
uniprot id: G7PMB0
names: Subcellular Location Annotation
messages: Nucleus

9541:DDB2
gene id: 9541:DDB2
uniprot id: A0A8J8XDL2
uniprot id: G7PQA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

9541:PSMB10
gene id: 9541:PSMB10
uniprot id: A0A7N9CQ77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9541:ARPC5L
gene id: 9541:ARPC5L
uniprot id: A0A2K5V8A3
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9541:LPAR3
gene id: 9541:LPAR3
uniprot id: A0A8J8YRY6
uniprot id: G7NTK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:S1PR2
gene id: 9541:S1PR2
uniprot id: A0A2K5UQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:TSPYL4
gene id: 9541:TSPYL4
uniprot id: Q9BDD7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9541:CMBL
gene id: 9541:CMBL
uniprot id: A0A8J8YI23
uniprot id: G7P784
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9541:SLC18B1
gene id: 9541:SLC18B1
uniprot id: G7P347
names: Subcellular Location Annotation
messages: Membrane

9541:ZNF75A
gene id: 9541:ZNF75A
uniprot id: G7Q0C4
names: Subcellular Location Annotation
messages: Nucleus

9541:COL4A5
gene id: 9541:COL4A5
uniprot id: A0A7N9D7T3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9541:LOC102139510
gene id: 9541:LOC102139510
uniprot id: A0A158SIQ0
uniprot id: Q8SPI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9541:SRFBP1
gene id: 9541:SRFBP1
uniprot id: A0A2K5UUQ8
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9541:MTURN
gene id: 9541:MTURN
uniprot id: A0A7N9C985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm

9541:SLAIN2
gene id: 9541:SLAIN2
uniprot id: A0A2K5VZE0
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9541:CYRIB
gene id: 9541:CYRIB
uniprot id: A0A2K5VZ03
uniprot id: A0A2K5VZ07
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9541:ATAD1
gene id: 9541:ATAD1
uniprot id: A0A2K5U312
uniprot id: A0A8J8XCG1
names: Similarity
messages: Belongs to the AAA ATPase family.

9541:ASPDH
gene id: 9541:ASPDH
uniprot id: A0A7N9C8S5
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9541:SERPINA1
gene id: 9541:SERPINA1
uniprot id: A0A2K5VCH9
names: Similarity
messages: Belongs to the serpin family.

9541:ATP5F1E
gene id: 9541:ATP5F1E
uniprot id: A0A2K5UDE9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9541:ACOT13
gene id: 9541:ACOT13
uniprot id: A0A2K5VB63
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9541:TPT1
gene id: 9541:TPT1
uniprot id: I7G286
names: Similarity
messages: Belongs to the TCTP family.

9541:B9D2
gene id: 9541:B9D2
uniprot id: A0A8J8Y908
uniprot id: G7PXN5
names: Subcellular Location Annotation
messages: cilium basal body

9541:LOC102123927
gene id: 9541:LOC102123927
uniprot id: A0A2K5VAA9
names: Similarity
messages: Belongs to the SPAN-X family.

9541:DDR2
gene id: 9541:DDR2
uniprot id: A0A2K5TSY1
names: Subcellular Location Annotation
messages: Membrane

9541:RAPGEF2
gene id: 9541:RAPGEF2
uniprot id: A0A2K5VJ56
uniprot id: A0A2K5VJE9
uniprot id: A0A7N9CTX2
uniprot id: A0A7N9CY37
uniprot id: G8F2H7
names: Similarity
messages: Belongs to the RAPGEF2 family.

9541:KCNE3
gene id: 9541:KCNE3
uniprot id: A0A2K5ULE3
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9541:DNASE1L3
gene id: 9541:DNASE1L3
uniprot id: A0A2K5VYE2
names: Similarity
messages: Belongs to the DNase I family.

9541:POLR3H
gene id: 9541:POLR3H
uniprot id: A0A8J8YFK6
uniprot id: G7PFN5
uniprot id: I7GKA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9541:PRM1
gene id: 9541:PRM1
uniprot id: A0A8J8XIC9
uniprot id: G7Q0H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protamine P1 family.
messages: Chromosome
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

9541:MS4A1
gene id: 9541:MS4A1
uniprot id: M4ZHZ6
names: Similarity
messages: Belongs to the MS4A family.

9541:EXOG
gene id: 9541:EXOG
uniprot id: A0A2K5U5P2
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9541:CFB
gene id: 9541:CFB
uniprot id: A0A2K5TZY3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:ATP5PO
gene id: 9541:ATP5PO
uniprot id: A0A7N9IET0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9541:HOXC12
gene id: 9541:HOXC12
uniprot id: A0A2K5TYK9
names: Subcellular Location Annotation
messages: Nucleus

9541:FLOT2
gene id: 9541:FLOT2
uniprot id: A0A2K5WXI8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane
messages: caveola

9541:ORC6
gene id: 9541:ORC6
uniprot id: A0A2K5UCL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9541:UTP23
gene id: 9541:UTP23
uniprot id: A0A2K5W9E8
names: Subcellular Location Annotation
messages: nucleolus

9541:NUF2
gene id: 9541:NUF2
uniprot id: A0A8J8YDP9
uniprot id: G7NU22
names: Similarity
messages: Belongs to the NUF2 family.

9541:SLC31A1
gene id: 9541:SLC31A1
uniprot id: A0A8J8XZ70
uniprot id: G7PRM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9541:APOM
gene id: 9541:APOM
uniprot id: G7P4P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9541:LOC102119500
gene id: 9541:LOC102119500
uniprot id: A0A2K5U2H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:MECOM
gene id: 9541:MECOM
uniprot id: A0A2K5V7G1
uniprot id: A0A7N9DAM4
names: Subcellular Location Annotation
messages: Nucleus

9541:PROKR1
gene id: 9541:PROKR1
uniprot id: A0A8J8YIK3
uniprot id: G7PMD0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:CHRM4
gene id: 9541:CHRM4
uniprot id: A0A8J8XC81
uniprot id: G7PQB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9541:STRADA
gene id: 9541:STRADA
uniprot id: A0A2K5U873
uniprot id: A0A8J8YRS4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9541:NEFL
gene id: 9541:NEFL
uniprot id: A0A2K5UWG6
names: Similarity
messages: Belongs to the intermediate filament family.

9541:ALG6
gene id: 9541:ALG6
uniprot id: A0A2K5WWB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:TAGLN3
gene id: 9541:TAGLN3
uniprot id: G8F2A6
uniprot id: Q4R5J4
names: Similarity
messages: Belongs to the calponin family.

9541:ZNF280C
gene id: 9541:ZNF280C
uniprot id: A0A2K5VYK8
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

9541:CACNB2
gene id: 9541:CACNB2
uniprot id: A0A2K5UYR3
uniprot id: A0A2K5UYS6
uniprot id: A0A2K5UYT7
uniprot id: A0A2K5UYV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

9541:SLC25A21
gene id: 9541:SLC25A21
uniprot id: A0A8J8YS57
uniprot id: G7PA42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:MCEE
gene id: 9541:MCEE
uniprot id: A0A2K5WLL5
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9541:TIGD2
gene id: 9541:TIGD2
uniprot id: A0A2K5UIV0
names: Subcellular Location Annotation
messages: Nucleus

9541:SYT14
gene id: 9541:SYT14
uniprot id: A0A2K5W3H5
names: Similarity
messages: Belongs to the synaptotagmin family.

9541:ACTG2
gene id: 9541:ACTG2
uniprot id: A0A8J8XMV4
uniprot id: G7PMI2
names: Similarity
messages: Belongs to the actin family.

9541:RBP5
gene id: 9541:RBP5
uniprot id: A0A2K5V0J2
uniprot id: A0A8J8Y0E2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:PLPP1
gene id: 9541:PLPP1
uniprot id: A0A2K5URB3
uniprot id: A0A7N9IE10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9541:NUDT11
gene id: 9541:NUDT11
uniprot id: A0A2K5U4Y1
uniprot id: G8F3J0
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9541:PLCB1
gene id: 9541:PLCB1
uniprot id: A0A2K5VG05
uniprot id: A0A2K5VG07
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9541:PYCR1
gene id: 9541:PYCR1
uniprot id: A0A2K5TMQ2
uniprot id: A0A8J8YL72
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9541:CAB39
gene id: 9541:CAB39
uniprot id: A0A8J8XGX5
uniprot id: G7PK94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9541:SMG9
gene id: 9541:SMG9
uniprot id: A0A2K5X1U7
names: Similarity
messages: Belongs to the SMG9 family.

9541:NDUFA8
gene id: 9541:NDUFA8
uniprot id: A0A8J8XH60
uniprot id: G7PRI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9541:CLDN10
gene id: 9541:CLDN10
uniprot id: A0A2K5UHD3
uniprot id: A0A2K5UHD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:TPR
gene id: 9541:TPR
uniprot id: A0A2K5V4Q4
names: Similarity
messages: Belongs to the TPR family.

9541:ERLIN1
gene id: 9541:ERLIN1
uniprot id: A0A8J8YBL7
uniprot id: G7PDQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9541:LOC102137297
gene id: 9541:LOC102137297
uniprot id: A0A2K5VW75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9541:SH3YL1
gene id: 9541:SH3YL1
uniprot id: A0A2K5TSP2
uniprot id: A0A7N9D3Y5
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9541:FABP1
gene id: 9541:FABP1
uniprot id: A0A2K5V1P3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9541:LSM3
gene id: 9541:LSM3
uniprot id: A0A2K5W897
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9541:XKRX
gene id: 9541:XKRX
uniprot id: G7Q383
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9541:PUS10
gene id: 9541:PUS10
uniprot id: A0A2K5X8M0
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

9541:FZD3
gene id: 9541:FZD3
uniprot id: A0A8J8XUY6
uniprot id: G7PCZ7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:OCLN
gene id: 9541:OCLN
uniprot id: A0A8J8XBB2
uniprot id: G7P7N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

9541:SUSD5
gene id: 9541:SUSD5
uniprot id: A0A2K5V7L9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TMTC4
gene id: 9541:TMTC4
uniprot id: A0A2K5VJM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9541:PAPSS1
gene id: 9541:PAPSS1
uniprot id: G7P619
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9541:HNRNPA3
gene id: 9541:HNRNPA3
uniprot id: A0A2K5UAW3
uniprot id: A0A7N9CZ09
names: Subcellular Location Annotation
messages: Nucleus

9541:KCND1
gene id: 9541:KCND1
uniprot id: A0A2K5UZL1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9541:LOC102121924
gene id: 9541:LOC102121924
uniprot id: G7PQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PROS1
gene id: 9541:PROS1
uniprot id: A0A2K5VES4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102145339
gene id: 9541:LOC102145339
uniprot id: A0A2K5UPJ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:PGAM2
gene id: 9541:PGAM2
uniprot id: A0A2K5V242
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9541:MOB1B
gene id: 9541:MOB1B
uniprot id: A0A2K5WX83
uniprot id: A0A2K5WXH6
names: Similarity
messages: Belongs to the MOB1/phocein family.

9541:ZMYND10
gene id: 9541:ZMYND10
uniprot id: A0A2K5X6W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite

9541:LOC102123539
gene id: 9541:LOC102123539
uniprot id: A0A8J8YJQ8
uniprot id: G7P2D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9541:PPTC7
gene id: 9541:PPTC7
uniprot id: A0A7N9D6U1
names: Similarity
messages: Belongs to the PP2C family.

9541:LOC102136165
gene id: 9541:LOC102136165
uniprot id: A0A2K5X3B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9541:SYPL2
gene id: 9541:SYPL2
uniprot id: A0A7N9IEZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9541:SND1
gene id: 9541:SND1
uniprot id: A0A2K5WL07
uniprot id: A0A8J8XDP7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9541:WDFY1
gene id: 9541:WDFY1
uniprot id: A0A2K5WRH3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9541:SLC35B1
gene id: 9541:SLC35B1
uniprot id: A0A8J8Y4I0
uniprot id: G7PU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9541:PRUNE1
gene id: 9541:PRUNE1
uniprot id: A0A2K5U0F8
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9541:JAKMIP2
gene id: 9541:JAKMIP2
uniprot id: A0A2K5VYD8
names: Similarity
messages: Belongs to the JAKMIP family.

9541:SEPHS1
gene id: 9541:SEPHS1
uniprot id: A0A2K5TWZ1
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9541:GTF2H1
gene id: 9541:GTF2H1
uniprot id: A0A2K5V602
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9541:IGF2BP2
gene id: 9541:IGF2BP2
uniprot id: A0A2K5X518
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9541:LOC102116763
gene id: 9541:LOC102116763
uniprot id: A0A8J8YGQ3
uniprot id: G7Q2M1
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9541:ACER2
gene id: 9541:ACER2
uniprot id: A0A8J8Y0D7
uniprot id: G7PSA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:LEF1
gene id: 9541:LEF1
uniprot id: A0A2K5W6A5
uniprot id: A0A2K5W6D6
uniprot id: A0A2K5W6D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9541:ATG4C
gene id: 9541:ATG4C
uniprot id: A0A8J8YN27
uniprot id: G7NW13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9541:CRYBB3
gene id: 9541:CRYBB3
uniprot id: A0A8J8YC17
uniprot id: G7PHE6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:ONECUT1
gene id: 9541:ONECUT1
uniprot id: A0A2K5UCR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9541:LIN54
gene id: 9541:LIN54
uniprot id: A0A2K5UTF2
uniprot id: G8F411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9541:UNC119B
gene id: 9541:UNC119B
uniprot id: A0A2K5X4B7
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9541:RPL5
gene id: 9541:RPL5
uniprot id: A0A2K5TJC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9541:LOC102146338
gene id: 9541:LOC102146338
uniprot id: A0A2K5VBJ9
uniprot id: G8F324
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:XRN1
gene id: 9541:XRN1
uniprot id: A0A2K5V3C7
uniprot id: A0A2K5V3D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9541:PDK3
gene id: 9541:PDK3
uniprot id: A0A2K5VFS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9541:COPS7A
gene id: 9541:COPS7A
uniprot id: A0A8J8Y6V2
uniprot id: G7PJN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9541:RPL37A
gene id: 9541:RPL37A
uniprot id: A0A7N9D9L4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9541:SGSM3
gene id: 9541:SGSM3
uniprot id: A0A2K5V2L3
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

9541:VXN
gene id: 9541:VXN
uniprot id: A0A8J8XEU3
uniprot id: G7PBY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vexin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus

9541:CAMKK2
gene id: 9541:CAMKK2
uniprot id: A0A7N9CZ65
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:GLB1L
gene id: 9541:GLB1L
uniprot id: G7PK43
uniprot id: Q95LV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 35 family.
messages: Probable glycosyl hydrolase.
messages: Secreted

9541:NATD1
gene id: 9541:NATD1
uniprot id: A0A7N9C8E1
names: Similarity
messages: Belongs to the NATD1 family.

9541:P2RY1
gene id: 9541:P2RY1
uniprot id: A0A8J8XTW9
uniprot id: G7NZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:G6PC1
gene id: 9541:G6PC1
uniprot id: A0A7N9IAD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9541:LOC102144453
gene id: 9541:LOC102144453
uniprot id: A0A7N9IDK4
names: Subcellular Location Annotation
messages: Nucleus

9541:HUS1
gene id: 9541:HUS1
uniprot id: A0A2K5U6G8
names: Similarity
messages: Belongs to the HUS1 family.

9541:CACNB4
gene id: 9541:CACNB4
uniprot id: A0A2K5VP04
uniprot id: A0A2K5VP40
uniprot id: A0A2K5VP41
uniprot id: A0A2K5VP77
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9541:RBM17
gene id: 9541:RBM17
uniprot id: A0A2K5V9A1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9541:CLNS1A
gene id: 9541:CLNS1A
uniprot id: A0A2K5VE65
uniprot id: G8F520
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9541:CDC42EP3
gene id: 9541:CDC42EP3
uniprot id: I7GEW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9541:POLR1E
gene id: 9541:POLR1E
uniprot id: A0A2K5VTT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9541:LOC102116561
gene id: 9541:LOC102116561
uniprot id: A0A2K5WZP4
uniprot id: A0A7N9IEQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

9541:SLF2
gene id: 9541:SLF2
uniprot id: G7PDS0
names: Similarity
messages: Belongs to the FAM178 family.

9541:WASHC3
gene id: 9541:WASHC3
uniprot id: A0A2K5UGQ0
uniprot id: G7PJB6
names: Similarity
messages: Belongs to the CCDC53 family.

9541:GOLPH3
gene id: 9541:GOLPH3
uniprot id: A0A2K5VT22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9541:CHUK
gene id: 9541:CHUK
uniprot id: A0A8J8XNK4
uniprot id: G7PDQ9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:CPNE4
gene id: 9541:CPNE4
uniprot id: A0A2K5UX78
uniprot id: A0A2K5UX88
names: Similarity
messages: Belongs to the copine family.

9541:CAMK1
gene id: 9541:CAMK1
uniprot id: A0A8J8Y5C5
uniprot id: G7NYU8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:ST3GAL5
gene id: 9541:ST3GAL5
uniprot id: A0A2K5VGK2
uniprot id: A0A2K5VGK8
uniprot id: A0A7N9D559
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:KCNT2
gene id: 9541:KCNT2
uniprot id: A0A2K5USG8
uniprot id: A0A2K5USL3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:HOXB2
gene id: 9541:HOXB2
uniprot id: A0A2K5U427
names: Subcellular Location Annotation
messages: Nucleus

9541:HSDL1
gene id: 9541:HSDL1
uniprot id: A0A8J8YE60
uniprot id: G7PZV5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:DDX47
gene id: 9541:DDX47
uniprot id: A0A2K5W149
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9541:LOC102129503
gene id: 9541:LOC102129503
uniprot id: G7PCD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:SLC20A1
gene id: 9541:SLC20A1
uniprot id: A0A7N9DB23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

9541:DUT
gene id: 9541:DUT
uniprot id: A0A2K5U4P8
uniprot id: I7GP54
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

9541:TMEM244
gene id: 9541:TMEM244
uniprot id: A0A8J8XJK9
uniprot id: G7P367
names: Subcellular Location Annotation
messages: Membrane

9541:NDUFA2
gene id: 9541:NDUFA2
uniprot id: G7P1Q5
uniprot id: G7P8H1
uniprot id: Q4R5E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:STK17A
gene id: 9541:STK17A
uniprot id: A0A7N9CRA5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:CABYR
gene id: 9541:CABYR
uniprot id: Q4R3X7
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with FSCB.
messages: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity).
messages: Phosphorylated on tyrosine residues during in vitro capacitation. Dephosphorylation affects its ability to bind calcium (By similarity).
messages: cytoskeleton
messages: flagellum

9541:MCOLN2
gene id: 9541:MCOLN2
uniprot id: A0A7N9CSJ3
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9541:CLCF1
gene id: 9541:CLCF1
uniprot id: A0A2K5WX50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9541:HPX
gene id: 9541:HPX
uniprot id: A0A2K5WVL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

9541:CCNA2
gene id: 9541:CCNA2
uniprot id: A0A2K5WIK0
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9541:BYSL
gene id: 9541:BYSL
uniprot id: A0A2K5V744
names: Similarity
messages: Belongs to the bystin family.

9541:HSPA4
gene id: 9541:HSPA4
uniprot id: A0A2K5UMB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9541:NMNAT2
gene id: 9541:NMNAT2
uniprot id: A0A2K5VI95
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9541:PRR15
gene id: 9541:PRR15
uniprot id: A0A8J8YSC4
uniprot id: G7P0H8
names: Similarity
messages: Belongs to the PRR15 family.

9541:SRP72
gene id: 9541:SRP72
uniprot id: A0A2K5UU62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

9541:MS4A5
gene id: 9541:MS4A5
uniprot id: A0A8J8Y424
uniprot id: G7PQ01
names: Similarity
messages: Belongs to the MS4A family.

9541:IL36B
gene id: 9541:IL36B
uniprot id: Q4R3X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9541:MT2A
gene id: 9541:MT2A
uniprot id: G7Q161
uniprot id: P68303
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
messages: This metallothionein binds zinc.

9541:AP3M2
gene id: 9541:AP3M2
uniprot id: A0A7N9DGA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9541:PEX7
gene id: 9541:PEX7
uniprot id: A0A2K5W3B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

9541:MED27
gene id: 9541:MED27
uniprot id: A0A8J8YJW3
uniprot id: G7PRA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9541:TTC39B
gene id: 9541:TTC39B
uniprot id: A0A2K5TYU0
names: Similarity
messages: Belongs to the TTC39 family.

9541:SEC22B
gene id: 9541:SEC22B
uniprot id: A0A8J8XBA0
uniprot id: G7NX73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9541:LOC102138501
gene id: 9541:LOC102138501
uniprot id: A0A2K5UQA7
names: Similarity
messages: Belongs to the GPRASP family.

9541:CSNK1A1
gene id: 9541:CSNK1A1
uniprot id: A0A2K5UU67
uniprot id: A0A7N9CID8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:SFRP4
gene id: 9541:SFRP4
uniprot id: A0A2K5WXT6
uniprot id: A0A8J8YNF6
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102119730
gene id: 9541:LOC102119730
uniprot id: A0A8J8XQP4
uniprot id: G7P2L5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:DDIT4
gene id: 9541:DDIT4
uniprot id: A0A2K5V7L1
uniprot id: A0A979HL08
names: Similarity
messages: Belongs to the DDIT4 family.

9541:SLC19A3
gene id: 9541:SLC19A3
uniprot id: A0A7N9DDZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
messages: Membrane

9541:AIF1
gene id: 9541:AIF1
uniprot id: A0A8J8XFL1
uniprot id: G7P4P6
names: Subcellular Location Annotation
messages: ruffle membrane

9541:MTMR3
gene id: 9541:MTMR3
uniprot id: A0A2K5WF31
uniprot id: A0A2K5WF62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9541:L3HYPDH
gene id: 9541:L3HYPDH
uniprot id: A0A7N9CWN8
uniprot id: A0A8J8XFF6
uniprot id: G7PAE6
names: Similarity
messages: Belongs to the proline racemase family.

9541:SMS
gene id: 9541:SMS
uniprot id: A0A2K5U1T0
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9541:RAB33A
gene id: 9541:RAB33A
uniprot id: A0A8J8XQ87
uniprot id: G7Q3N9
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9541:CNTFR
gene id: 9541:CNTFR
uniprot id: A0A2K5WIH9
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9541:DRAM2
gene id: 9541:DRAM2
uniprot id: A0A2K5VMD4
names: Subcellular Location Annotation
messages: Membrane

9541:FZR1
gene id: 9541:FZR1
uniprot id: A0A2K5WA62
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9541:KIAA1191
gene id: 9541:KIAA1191
uniprot id: A0A2K5U4M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9541:CHRNA1
gene id: 9541:CHRNA1
uniprot id: A0A2K5VCW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:ATP6V1C2
gene id: 9541:ATP6V1C2
uniprot id: A0A2K5V5C1
uniprot id: A0A7N9CER9
uniprot id: A0A8J8XE37
uniprot id: G7PLL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9541:LPIN1
gene id: 9541:LPIN1
uniprot id: A0A2K5VB78
uniprot id: A0A2K5VBA0
names: Similarity
messages: Belongs to the lipin family.

9541:GMFG
gene id: 9541:GMFG
uniprot id: A0A2K5W3U4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9541:NGF
gene id: 9541:NGF
uniprot id: G7NX40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted

9541:LGMN
gene id: 9541:LGMN
uniprot id: A0A2K5VM53
uniprot id: A0A8J8Y362
names: Similarity
messages: Belongs to the peptidase C13 family.

9541:SLC35B2
gene id: 9541:SLC35B2
uniprot id: A0A2K5WK56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9541:ELOC
gene id: 9541:ELOC
uniprot id: A0A2K5WLS2
names: Similarity
messages: Belongs to the SKP1 family.

9541:CWF19L1
gene id: 9541:CWF19L1
uniprot id: A0A2K5UUK7
uniprot id: A0A2K5UUP3
names: Similarity
messages: Belongs to the CWF19 family.

9541:FGF9
gene id: 9541:FGF9
uniprot id: A0A8J8XCT6
uniprot id: G7PVU6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:SLC25A11
gene id: 9541:SLC25A11
uniprot id: A0A2K5WNM7
uniprot id: A0A8J8YAW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:ATP1B4
gene id: 9541:ATP1B4
uniprot id: A0A2K5WZW9
uniprot id: A0A8J8Y471
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9541:KCTD11
gene id: 9541:KCTD11
uniprot id: A0A2K5UD36
names: Subcellular Location Annotation
messages: Cell membrane

9541:MAP2K5
gene id: 9541:MAP2K5
uniprot id: A0A2K5UQ60
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:MRPL36
gene id: 9541:MRPL36
uniprot id: G8F2L2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9541:LOC101866265
gene id: 9541:LOC101866265
uniprot id: A0A2K5UB93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9541:DYNLL2
gene id: 9541:DYNLL2
uniprot id: A0A2K5VTY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9541:GPR55
gene id: 9541:GPR55
uniprot id: A0A8J8XZW1
uniprot id: G7PK96
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:ZNF500
gene id: 9541:ZNF500
uniprot id: A0A2K5V409
names: Subcellular Location Annotation
messages: Nucleus

9541:SYN3
gene id: 9541:SYN3
uniprot id: A0A2K5V0P4
names: Similarity
messages: Belongs to the synapsin family.

9541:CDC5L
gene id: 9541:CDC5L
uniprot id: A0A8J8YB92
uniprot id: G7P4R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEF1 family.
messages: Nucleus

9541:CDC73
gene id: 9541:CDC73
uniprot id: A0A8J8YD42
uniprot id: G7NXD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

9541:LOC102133200
gene id: 9541:LOC102133200
uniprot id: A0A7N9CF85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:EPHA4
gene id: 9541:EPHA4
uniprot id: A0A8J8XAZ2
uniprot id: G7PK59
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9541:ENTPD1
gene id: 9541:ENTPD1
uniprot id: A0A7N9DGH8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9541:LOC102125891
gene id: 9541:LOC102125891
uniprot id: A0A2K5X524
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:MGAT4A
gene id: 9541:MGAT4A
uniprot id: G7PMT1
uniprot id: Q4R854
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity).
messages: Golgi apparatus membrane
messages: Inhibited by UDP.
messages: N-glycosylated.
messages: Secreted

9541:GATC
gene id: 9541:GATC
uniprot id: A0A8J8XNI1
uniprot id: G7PJ44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9541:C5H4orf47
gene id: 9541:C5H4orf47
uniprot id: A0A2K5WAQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP96 family.
messages: centrosome

9541:CYP27A1
gene id: 9541:CYP27A1
uniprot id: B8K1T2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:DLG1
gene id: 9541:DLG1
uniprot id: A0A2K5TR55
uniprot id: A0A2K5TR64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9541:CHMP4B
gene id: 9541:CHMP4B
uniprot id: A0A2K5WZD2
names: Similarity
messages: Belongs to the SNF7 family.

9541:NUDT6
gene id: 9541:NUDT6
uniprot id: A0A2K5VM39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

9541:SESN1
gene id: 9541:SESN1
uniprot id: A0A8J8XG88
uniprot id: Q4R6P7
uniprot id: Q4R7Y6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sestrin family.
messages: Cytoplasm
messages: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.
messages: Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine. Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them. Interacts with KEAP1, RBX1 and SQSTM1; in the SQSTM1-dependent autophagic degradation of KEAP1. May interact with PRDX1.
messages: Nucleus
messages: The C-terminal domain mediates interaction with GATOR2 through which it regulates TORC1 signaling.
messages: The N-terminal domain may have an alkylhydroperoxide reductase activity.

9541:CMPK1
gene id: 9541:CMPK1
uniprot id: A0A2K5VB30
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9541:VIRMA
gene id: 9541:VIRMA
uniprot id: A0A2K5VWG2
names: Similarity
messages: Belongs to the vir family.

9541:DPYSL2
gene id: 9541:DPYSL2
uniprot id: A0A2K5UCM5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9541:LOC102143773
gene id: 9541:LOC102143773
uniprot id: A0A2K5V0I8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.

9541:LECT2
gene id: 9541:LECT2
uniprot id: A0A2K5V3L4
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9541:CARMIL3
gene id: 9541:CARMIL3
uniprot id: A0A2K5TK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9541:RPL15
gene id: 9541:RPL15
uniprot id: Q4R5B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. Interacts with IFIT1 (via TPR repeats 1-4).
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9541:CHST11
gene id: 9541:CHST11
uniprot id: A0A8J8YIA6
uniprot id: G7PJD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:EPC1
gene id: 9541:EPC1
uniprot id: A0A2K5TPI8
uniprot id: A0A2K5TPK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9541:YEATS4
gene id: 9541:YEATS4
uniprot id: A0A8J8XS80
uniprot id: G7PI06
names: Subcellular Location Annotation
messages: Nucleus

9541:MRPL23
gene id: 9541:MRPL23
uniprot id: A0A2K5WGW3
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9541:HTR7
gene id: 9541:HTR7
uniprot id: A0A2K5U8R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:EEF2K
gene id: 9541:EEF2K
uniprot id: A0A8J8XP58
uniprot id: G7Q0P5
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9541:LOC101865434
gene id: 9541:LOC101865434
uniprot id: A0A2K5X5U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

9541:NUP205
gene id: 9541:NUP205
uniprot id: A0A2K5WJA6
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

9541:KRTCAP2
gene id: 9541:KRTCAP2
uniprot id: A0A2K5WII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9541:LOC102117030
gene id: 9541:LOC102117030
uniprot id: A0A8J8YEL1
uniprot id: G7PQW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ISCA2
gene id: 9541:ISCA2
uniprot id: A0A7N9CFA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9541:LOC101866469
gene id: 9541:LOC101866469
uniprot id: G7P578
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9541:LIPF
gene id: 9541:LIPF
uniprot id: A0A2K5VBR3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9541:CYP7A1
gene id: 9541:CYP7A1
uniprot id: A0A8J8XBY6
uniprot id: G7PBW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9541:CCDC25
gene id: 9541:CCDC25
uniprot id: A0A2K5VAU4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9541:OS9
gene id: 9541:OS9
uniprot id: A0A2K5TS93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9541:ABCG8
gene id: 9541:ABCG8
uniprot id: A0A2K5VTH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9541:SNAP25
gene id: 9541:SNAP25
uniprot id: A0A7N9CTS0
uniprot id: A0A8J8YHL9
uniprot id: G7PGZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9541:TUBB6
gene id: 9541:TUBB6
uniprot id: A0A2K5WZE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9541:GNGT2
gene id: 9541:GNGT2
uniprot id: A0A2K5U966
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:FRZB
gene id: 9541:FRZB
uniprot id: A0A2K5V9H7
names: Caution
names: Function
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9541:EXTL2
gene id: 9541:EXTL2
uniprot id: A0A2K5U7X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:KDELR2
gene id: 9541:KDELR2
uniprot id: A0A2K5WKI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

9541:LOC102123198
gene id: 9541:LOC102123198
uniprot id: Q28482
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RPA2
gene id: 9541:RPA2
uniprot id: A0A2K5UIM7
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

9541:LOC102124147
gene id: 9541:LOC102124147
uniprot id: A0A2K5UCV1
uniprot id: A0A7N9DFH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:LOC102145066
gene id: 9541:LOC102145066
uniprot id: G7PWP2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9541:SLC16A1
gene id: 9541:SLC16A1
uniprot id: A0A8J8XTQ4
uniprot id: G7NW70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9541:LOC101865393
gene id: 9541:LOC101865393
uniprot id: A0A8J8YNH3
uniprot id: G7PU91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9541:DUSP6
gene id: 9541:DUSP6
uniprot id: A0A2K5WMF4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9541:SENP1
gene id: 9541:SENP1
uniprot id: A0A2K5TUE6
names: Similarity
messages: Belongs to the peptidase C48 family.

9541:GFOD1
gene id: 9541:GFOD1
uniprot id: A0A8J8XSS3
uniprot id: G7P4F9
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9541:ZDHHC15
gene id: 9541:ZDHHC15
uniprot id: A0A2K5WVP5
uniprot id: A0A8J8XFW1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:ADPRS
gene id: 9541:ADPRS
uniprot id: A0A2K5WFG0
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9541:FAR1
gene id: 9541:FAR1
uniprot id: A0A2K5V668
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9541:UBE2L6
gene id: 9541:UBE2L6
uniprot id: A0A7N9DDL7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:GLCE
gene id: 9541:GLCE
uniprot id: A0A8J8Y221
uniprot id: G7P900
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9541:SEC22C
gene id: 9541:SEC22C
uniprot id: A0A8J8Y5P5
uniprot id: G7NY71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9541:CREM
gene id: 9541:CREM
uniprot id: A0A2K5VKL3
uniprot id: A0A7N9DAB8
names: Subcellular Location Annotation
messages: Nucleus

9541:CDNF
gene id: 9541:CDNF
uniprot id: A0A8J8YCX8
uniprot id: G7PEE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9541:ARPC1B
gene id: 9541:ARPC1B
uniprot id: A0A2K5WSY0
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9541:LOC102122868
gene id: 9541:LOC102122868
uniprot id: A0A7N9IBE1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9541:SEC22A
gene id: 9541:SEC22A
uniprot id: G7NYD2
uniprot id: Q4R866
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9541:NUBPL
gene id: 9541:NUBPL
uniprot id: A0A8J8XZC4
uniprot id: G7PA18
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9541:CCN1
gene id: 9541:CCN1
uniprot id: A0A2K5U3T5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:ALG8
gene id: 9541:ALG8
uniprot id: A0A2K5TXX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:CFAP107
gene id: 9541:CFAP107
uniprot id: A0A8J8YNK1
uniprot id: G7NU70
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9541:EAF2
gene id: 9541:EAF2
uniprot id: A0A2K5WT64
names: Similarity
messages: Belongs to the EAF family.

9541:MPHOSPH10
gene id: 9541:MPHOSPH10
uniprot id: A0A7N9CX54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9541:LOC102121218
gene id: 9541:LOC102121218
uniprot id: A0A2K5U687
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9541:CTSE
gene id: 9541:CTSE
uniprot id: A0A2K5UJB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Secreted

9541:ATP1A1
gene id: 9541:ATP1A1
uniprot id: A0A2K5WIP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9541:SUV39H1
gene id: 9541:SUV39H1
uniprot id: A0A2K5VYE5
uniprot id: A0A7N9CQR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9541:PHACTR3
gene id: 9541:PHACTR3
uniprot id: A0A2K5WI24
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9541:LOC102131468
gene id: 9541:LOC102131468
uniprot id: A0A2K5TML4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9541:LOC101925149
gene id: 9541:LOC101925149
uniprot id: A0A7N9D0E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

9541:MRE11
gene id: 9541:MRE11
uniprot id: A0A2K5X3W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9541:LOC102139994
gene id: 9541:LOC102139994
uniprot id: A0A2K5VY81
names: Similarity
messages: Belongs to the MHC class II family.

9541:ARRB1
gene id: 9541:ARRB1
uniprot id: A0A2K5W2V3
names: Similarity
messages: Belongs to the arrestin family.

9541:CXCL9
gene id: 9541:CXCL9
uniprot id: A0A2K5WYG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:LOC102137787
gene id: 9541:LOC102137787
uniprot id: G7NW93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PHF5A
gene id: 9541:PHF5A
uniprot id: A0A8J8Y2R2
uniprot id: G7PFN3
names: Similarity
messages: Belongs to the PHF5 family.

9541:SIDT2
gene id: 9541:SIDT2
uniprot id: A0A2K5V6U2
uniprot id: G7PP16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9541:SZRD1
gene id: 9541:SZRD1
uniprot id: A0A7N9CZQ5
names: Similarity
messages: Belongs to the SZRD1 family.

9541:RPL35A
gene id: 9541:RPL35A
uniprot id: G8F3S7
uniprot id: P61272
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL33 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells.
messages: Cytoplasm

9541:MORF4L1
gene id: 9541:MORF4L1
uniprot id: A0A2K5UEY5
names: Subcellular Location Annotation
messages: Nucleus

9541:HAT1
gene id: 9541:HAT1
uniprot id: A0A8J8YED4
uniprot id: G7PKT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9541:ASB7
gene id: 9541:ASB7
uniprot id: A0A8J8YNA7
uniprot id: G7P9J5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:RND3
gene id: 9541:RND3
uniprot id: A0A8J8YQU8
uniprot id: G7PKK2
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9541:STOML2
gene id: 9541:STOML2
uniprot id: G7PS14
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9541:LOC107130570
gene id: 9541:LOC107130570
uniprot id: A0A7N9D7A9
names: Subcellular Location Annotation
messages: Secreted

9541:LOC102138425
gene id: 9541:LOC102138425
uniprot id: G8F3E6
names: Similarity
messages: Belongs to the LCE family.

9541:DDX6
gene id: 9541:DDX6
uniprot id: A0A2K5W0J2
names: Similarity
messages: Belongs to the DEAD box helicase family.

9541:LOC102121747
gene id: 9541:LOC102121747
uniprot id: G7PHX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:LOC102145420
gene id: 9541:LOC102145420
uniprot id: A0A7N9D6B8
uniprot id: A0A8J8YFM8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:KCNJ11
gene id: 9541:KCNJ11
uniprot id: A0A8J8YNU2
uniprot id: G7PQM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9541:ACTN4
gene id: 9541:ACTN4
uniprot id: A0A2K5TSR0
names: Similarity
messages: Belongs to the alpha-actinin family.

9541:SLC41A1
gene id: 9541:SLC41A1
uniprot id: A0A2K5VWR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9541:NAA35
gene id: 9541:NAA35
uniprot id: G7PSM3
uniprot id: Q4R708
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9541:ACSL4
gene id: 9541:ACSL4
uniprot id: A0A8J8YEM6
uniprot id: G7Q3G4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:USP7
gene id: 9541:USP7
uniprot id: A0A2K5X2D8
names: Similarity
messages: Belongs to the peptidase C19 family.

9541:GJB1
gene id: 9541:GJB1
uniprot id: A0A7N9CAQ4
uniprot id: G8F3U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:LOC107129591
gene id: 9541:LOC107129591
uniprot id: G7P2L6
uniprot id: G7P2P0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:CCND1
gene id: 9541:CCND1
uniprot id: A0A2K5TKJ8
names: Similarity
messages: Belongs to the cyclin family.

9541:CUL3
gene id: 9541:CUL3
uniprot id: A0A2K5W2Z2
uniprot id: A0A2K5W2Z9
names: Similarity
messages: Belongs to the cullin family.

9541:DOK5
gene id: 9541:DOK5
uniprot id: A0A2K5V0K2
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9541:CCL8
gene id: 9541:CCL8
uniprot id: G7PU24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:LOC102117144
gene id: 9541:LOC102117144
uniprot id: G7P2Q3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:NT5C3A
gene id: 9541:NT5C3A
uniprot id: A0A2K5WTY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9541:CYLD
gene id: 9541:CYLD
uniprot id: A0A2K5VGV6
uniprot id: A0A7N9CUC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9541:PYM1
gene id: 9541:PYM1
uniprot id: A0A2K5W7E5
uniprot id: A0A2K5W7I1
names: Similarity
names: Subunit
messages: Belongs to the pym family.
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

9541:RGR
gene id: 9541:RGR
uniprot id: A0A7N9CQU1
names: Subcellular Location Annotation
messages: Membrane

9541:RNF43
gene id: 9541:RNF43
uniprot id: A0A2K5VQE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

9541:MACIR
gene id: 9541:MACIR
uniprot id: A0A8J8YQW5
uniprot id: G7P810
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9541:KCNH8
gene id: 9541:KCNH8
uniprot id: A0A2K5VBB6
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9541:ACKR4
gene id: 9541:ACKR4
uniprot id: A0A8J8Y5K1
uniprot id: G7NXZ5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:ARMCX3
gene id: 9541:ARMCX3
uniprot id: A0A7N9CXV7
uniprot id: A0A8J8XM55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9541:FGD6
gene id: 9541:FGD6
uniprot id: A0A2K5WL46
uniprot id: A0A2K5WL79
names: Subcellular Location Annotation
messages: cytoskeleton

9541:IRF5
gene id: 9541:IRF5
uniprot id: A0A2K5VH46
names: Subcellular Location Annotation
messages: Nucleus

9541:PIP4P1
gene id: 9541:PIP4P1
uniprot id: Q4R6W2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (By similarity). May play a role in the regulation of cellular cholesterol metabolism (By similarity).
messages: Cell membrane
messages: Interacts (via transmembrane domain) with ATP6V0D1 (By similarity). Interacts with LAMTOR1, RRAGA and RRAGC (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: phagosome membrane

9541:EPS8L3
gene id: 9541:EPS8L3
uniprot id: A0A2K5WUW4
names: Similarity
messages: Belongs to the EPS8 family.

9541:GGA3
gene id: 9541:GGA3
uniprot id: A0A2K5U969
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9541:ACADM
gene id: 9541:ACADM
uniprot id: A0A2K5V3V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Mitochondrion matrix

9541:SLC25A46
gene id: 9541:SLC25A46
uniprot id: A0A2K5WSG9
uniprot id: Q4R3T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

9541:TMEFF2
gene id: 9541:TMEFF2
uniprot id: A0A2K5UWD7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:FAM200A
gene id: 9541:FAM200A
uniprot id: Q4R6P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM200 family.
messages: Membrane

9541:SLC25A38
gene id: 9541:SLC25A38
uniprot id: A0A7N9IC41
uniprot id: A0A8J8YS09
uniprot id: G7NYJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9541:GPX8
gene id: 9541:GPX8
uniprot id: G7P7I5
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9541:MRPS24
gene id: 9541:MRPS24
uniprot id: A0A2K5W9U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9541:DDRGK1
gene id: 9541:DDRGK1
uniprot id: G7PGU8
names: Similarity
messages: Belongs to the DDRGK1 family.

9541:SLC5A11
gene id: 9541:SLC5A11
uniprot id: A0A2K5VPW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9541:CD28
gene id: 9541:CD28
uniprot id: A0A2K5WCD2
names: Subcellular Location Annotation
messages: Membrane

9541:GALNT18
gene id: 9541:GALNT18
uniprot id: A0A2K5WV86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:EIF3K
gene id: 9541:EIF3K
uniprot id: A0A2K5X240
uniprot id: G8F5R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9541:HARBI1
gene id: 9541:HARBI1
uniprot id: A0A2K5TZV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9541:MRPL2
gene id: 9541:MRPL2
uniprot id: A0A7N9CAW8
uniprot id: A0A8J8XHY5
uniprot id: G7P3Z3
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9541:ACAP2
gene id: 9541:ACAP2
uniprot id: A0A7N9IDL1
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9541:TMEM176B
gene id: 9541:TMEM176B
uniprot id: A0A2K5VMR3
names: Similarity
messages: Belongs to the TMEM176 family.

9541:SGSM1
gene id: 9541:SGSM1
uniprot id: A0A2K5UJ30
uniprot id: A0A7N9C9P6
names: Similarity
messages: Belongs to the RUTBC family.

9541:PRSS16
gene id: 9541:PRSS16
uniprot id: A0A2K5WDF6
names: Similarity
messages: Belongs to the peptidase S28 family.

9541:RAB39B
gene id: 9541:RAB39B
uniprot id: A0A8J8XD78
uniprot id: G7Q238
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9541:TNFAIP3
gene id: 9541:TNFAIP3
uniprot id: A0A2K5X7A9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:FUBP1
gene id: 9541:FUBP1
uniprot id: A0A7N9D6Y9
names: Subcellular Location Annotation
messages: Nucleus

9541:CAB39L
gene id: 9541:CAB39L
uniprot id: A0A8J8XN18
uniprot id: G7PVE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9541:ABITRAM
gene id: 9541:ABITRAM
uniprot id: A0A2K5W2H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9541:PDE4D
gene id: 9541:PDE4D
uniprot id: A0A2K5VWF6
uniprot id: A0A2K5VWJ8
uniprot id: A0A2K5VWK7
uniprot id: A0A2K5VWK9
uniprot id: A0A2K5VWL9
uniprot id: A0A2K5VWR4
uniprot id: A0A7N9D392
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:DEFB123
gene id: 9541:DEFB123
uniprot id: A0A8J8XK90
uniprot id: G7PGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:RNF40
gene id: 9541:RNF40
uniprot id: A0A2K5V529
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9541:MMP13
gene id: 9541:MMP13
uniprot id: A0A2K5U988
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9541:NAPRT
gene id: 9541:NAPRT
uniprot id: A0A2K5X066
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

9541:LHX2
gene id: 9541:LHX2
uniprot id: A0A2K5ULQ9
names: Subcellular Location Annotation
messages: Nucleus

9541:PLOD2
gene id: 9541:PLOD2
uniprot id: A0A2K5WMI3
uniprot id: A0A2K5WMZ3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9541:UHRF2
gene id: 9541:UHRF2
uniprot id: A0A7N9DBW3
uniprot id: A0A7N9IGB3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

9541:MTMR6
gene id: 9541:MTMR6
uniprot id: A0A2K5V469
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9541:CCK
gene id: 9541:CCK
uniprot id: I7GJF3
uniprot id: P23362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gastrin/cholecystokinin family.
messages: Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.
messages: Secreted
messages: The precursor is cleaved by ACE, which removes the Gly-Arg-Arg peptide at the C-terminus, leading to mature hormone.
messages: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
messages: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

9541:GSKIP
gene id: 9541:GSKIP
uniprot id: A0A2K5X3U9
names: Similarity
messages: Belongs to the GSKIP family.

9541:PTPN1
gene id: 9541:PTPN1
uniprot id: A0A7N9I9Q8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9541:EEF1D
gene id: 9541:EEF1D
uniprot id: A0A2K5WG05
uniprot id: A0A805R9Y0
uniprot id: Q4R3D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta isoform 1, and gamma. Isoform 2 interacts with HSF1 and NFE2L2 (By similarity).
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.
messages: Nucleus
messages: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).

9541:TAFAZZIN
gene id: 9541:TAFAZZIN
uniprot id: A0A2K5UMJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9541:DPM1
gene id: 9541:DPM1
uniprot id: A0A2K5W3B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9541:NT5E
gene id: 9541:NT5E
uniprot id: A0A2K5V5U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9541:SLC22A7
gene id: 9541:SLC22A7
uniprot id: A0A2K5TPK7
names: Subcellular Location Annotation
messages: Membrane

9541:SENP7
gene id: 9541:SENP7
uniprot id: A0A7N9CBT5
uniprot id: A0A7N9CR70
uniprot id: A0A7N9CWC6
uniprot id: A0A7N9D5A5
uniprot id: A0A7N9IGX0
names: Similarity
messages: Belongs to the peptidase C48 family.

9541:TCL1B
gene id: 9541:TCL1B
uniprot id: G7PBF1
names: Similarity
messages: Belongs to the TCL1 family.

9541:WNT10B
gene id: 9541:WNT10B
uniprot id: A0A2K5VIT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:HOXA1
gene id: 9541:HOXA1
uniprot id: A0A8J8Y696
uniprot id: G7P0P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9541:DNASE1
gene id: 9541:DNASE1
uniprot id: A0A7N9CGN5
uniprot id: A0A7N9I9E6
names: Similarity
messages: Belongs to the DNase I family.

9541:CHRNG
gene id: 9541:CHRNG
uniprot id: A0A2K5TS72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:ZFP69B
gene id: 9541:ZFP69B
uniprot id: A0A2K5VHX0
names: Subcellular Location Annotation
messages: Nucleus

9541:SLAIN1
gene id: 9541:SLAIN1
uniprot id: A0A2K5W6E7
uniprot id: A0A2K5W6F3
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9541:GNPAT
gene id: 9541:GNPAT
uniprot id: A0A2K5V912
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9541:TSEN15
gene id: 9541:TSEN15
uniprot id: A0A2K5U572
uniprot id: A0A2K5U5A3
names: Similarity
messages: Belongs to the SEN15 family.

9541:IMMP1L
gene id: 9541:IMMP1L
uniprot id: A0A2K5UQ55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9541:BAP1
gene id: 9541:BAP1
uniprot id: A0A8J8YI92
uniprot id: G7NZW2
names: Similarity
messages: Belongs to the peptidase C12 family.

9541:C7H15orf40
gene id: 9541:C7H15orf40
uniprot id: A0A2K5X2R8
names: Similarity
messages: Belongs to the UPF0235 family.

9541:TM6SF2
gene id: 9541:TM6SF2
uniprot id: A0A2K5UD60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

9541:DCTN1
gene id: 9541:DCTN1
uniprot id: A0A2K5TMV3
uniprot id: G7PMI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

9541:DTNA
gene id: 9541:DTNA
uniprot id: A0A2K5UWT3
uniprot id: A0A2K5UX96
uniprot id: A0A2K5UXH1
uniprot id: A0A2K5UXM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9541:URAD
gene id: 9541:URAD
uniprot id: A0A2K5VFU0
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9541:MARK3
gene id: 9541:MARK3
uniprot id: A0A2K5TVC1
uniprot id: A0A2K5TVG8
uniprot id: A0A2K5TVI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9541:KCNIP4
gene id: 9541:KCNIP4
uniprot id: Q8HYN7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the recoverin family.
messages: Cell membrane
messages: Component of heteromultimeric potassium channels (By similarity). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Interacts with KCND2 (By similarity). Interacts with KCND3 (By similarity). Interacts with the C-terminus of PSEN2 and probably PSEN1 (By similarity).
messages: Cytoplasm
messages: Peroxisome
messages: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
messages: The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current.

9541:ELF1
gene id: 9541:ELF1
uniprot id: A0A8J8YI97
uniprot id: G7PW33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:MZT2B
gene id: 9541:MZT2B
uniprot id: A0A2K5WDI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9541:STRADB
gene id: 9541:STRADB
uniprot id: A0A2K5TJ72
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9541:TIMP1
gene id: 9541:TIMP1
uniprot id: A0A2K5WNU0
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9541:PCOLCE
gene id: 9541:PCOLCE
uniprot id: A0A2K5WMV4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:SDC2
gene id: 9541:SDC2
uniprot id: I7G7X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9541:TRAF6
gene id: 9541:TRAF6
uniprot id: A0A2K5WZD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9541:ERCC1
gene id: 9541:ERCC1
uniprot id: A0A2K5TVW5
uniprot id: A0A2K5TVW7
uniprot id: A0A7N9IFE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

9541:YTHDF1
gene id: 9541:YTHDF1
uniprot id: A0A2K5U357
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9541:RPL35
gene id: 9541:RPL35
uniprot id: A0A2K5VJW4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9541:NDUFB3
gene id: 9541:NDUFB3
uniprot id: A0A2K5USP8
uniprot id: G7PMD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9541:TSPAN7
gene id: 9541:TSPAN7
uniprot id: Q4R5A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:YOD1
gene id: 9541:YOD1
uniprot id: A0A2K5UQS7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9541:VPS26C
gene id: 9541:VPS26C
uniprot id: A0A2K5VWC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9541:NDRG1
gene id: 9541:NDRG1
uniprot id: A0A805QPH7
uniprot id: Q4R4Q3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDRG family.
messages: Cell membrane
messages: Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling ofCDH1. Interacts with APOA1, APOA2, PRA1 and RTN1 (By similarity).
messages: Nucleus
messages: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity).
messages: Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent (By similarity).
messages: centrosome
messages: cytosol

9541:PON1
gene id: 9541:PON1
uniprot id: A0A8J8YQD9
uniprot id: G7P1C5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9541:CFAP418
gene id: 9541:CFAP418
uniprot id: A0A2K5VME6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9541:PPARD
gene id: 9541:PPARD
uniprot id: A0A2K5W3V1
uniprot id: G7P2V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:CCL17
gene id: 9541:CCL17
uniprot id: A0A2K5UW77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:SPDL1
gene id: 9541:SPDL1
uniprot id: Q4R7H3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect. Interacts with dynein intermediate chain and dynactin (DCTN1) (By similarity). Interacts with the catalytically active form of USP45 (By similarity).
messages: Monoubiquitinated with'Lys-48' linkage (By similarity). Deubiquitinated by USP45 (By similarity).
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Plays a role in cell migration (By similarity).
messages: centrosome
messages: kinetochore
messages: spindle pole

9541:KLC1
gene id: 9541:KLC1
uniprot id: A0A2K5UQK2
uniprot id: A0A2K5UQN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9541:ATP1B2
gene id: 9541:ATP1B2
uniprot id: A0A2K5X586
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9541:CDK2AP1
gene id: 9541:CDK2AP1
uniprot id: A0A7N9DAR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9541:RAD18
gene id: 9541:RAD18
uniprot id: A0A2K5UMD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9541:STXBP1
gene id: 9541:STXBP1
uniprot id: A0A2K5WGR0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9541:GLYAT
gene id: 9541:GLYAT
uniprot id: A0A2K5UI23
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9541:MRPL19
gene id: 9541:MRPL19
uniprot id: A0A2K5VJ67
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9541:LOC102122546
gene id: 9541:LOC102122546
uniprot id: A0A2K5VRN2
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9541:WNT8B
gene id: 9541:WNT8B
uniprot id: A0A2K5V9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:FCER1G
gene id: 9541:FCER1G
uniprot id: Q8SPW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (By similarity). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer of CD247 and FCER1G, associates with the ligand binding subunit FCGR3A to form a functional receptor complex (By similarity). Associates with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (By similarity). Interacts with CD300LH; the interaction may be indirect. Interacts with CD300LD (By similarity). Interacts with TARM1 (By similarity).

9541:DBX1
gene id: 9541:DBX1
uniprot id: A0A2K5V3H5
names: Subcellular Location Annotation
messages: Nucleus

9541:STAG2
gene id: 9541:STAG2
uniprot id: A0A2K5USA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9541:NKAIN2
gene id: 9541:NKAIN2
uniprot id: A0A2K5WHB5
uniprot id: G7P387
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9541:PTN
gene id: 9541:PTN
uniprot id: A0A2K5VRF2
uniprot id: A0A2K5VRP8
names: Similarity
messages: Belongs to the pleiotrophin family.

9541:NME9
gene id: 9541:NME9
uniprot id: A0A2K5V278
uniprot id: A0A8J8XRC5
uniprot id: G7P034
names: Similarity
messages: Belongs to the NDK family.

9541:MEOX1
gene id: 9541:MEOX1
uniprot id: A0A2K5TMY3
names: Subcellular Location Annotation
messages: Nucleus

9541:CBLC
gene id: 9541:CBLC
uniprot id: A0A2K5V7G2
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9541:USP14
gene id: 9541:USP14
uniprot id: A0A2K5U7L4
uniprot id: A0A7N9CZD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9541:LOC102146459
gene id: 9541:LOC102146459
uniprot id: A0A8J8YEU4
uniprot id: G7Q3I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9541:ARF1
gene id: 9541:ARF1
uniprot id: A0A158SIP9
uniprot id: Q4R5P2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive GDP-bound form and an active GTP-bound form. Intrinsic GTPase activity is almost undetectable in vitro. Activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs).
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus
messages: Golgi apparatus membrane
messages: Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1. Interacts with C9orf72.
messages: Postsynaptic density
messages: Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity).
messages: synaptosome

9541:SLC7A8
gene id: 9541:SLC7A8
uniprot id: A0A2K5U9B8
uniprot id: A0A8J8YCV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9541:RPL19
gene id: 9541:RPL19
uniprot id: G7NZM6
uniprot id: Q8HXN9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Citrullinated by PADI4.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9541:GPR83
gene id: 9541:GPR83
uniprot id: A0A7N9CN28
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:MAPRE2
gene id: 9541:MAPRE2
uniprot id: A0A2K5X8Q4
uniprot id: A0A2K5X8R3
uniprot id: A0A2K5X8U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9541:FOXB1
gene id: 9541:FOXB1
uniprot id: A0A2K5UFL3
names: Subcellular Location Annotation
messages: Nucleus

9541:EFS
gene id: 9541:EFS
uniprot id: A0A2K5TRI6
uniprot id: A0A7N9D1U2
names: Similarity
messages: Belongs to the CAS family.

9541:ZHX2
gene id: 9541:ZHX2
uniprot id: G7PCR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9541:RMI1
gene id: 9541:RMI1
uniprot id: A0A2K5UFH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9541:LOC102138137
gene id: 9541:LOC102138137
uniprot id: G7P2N0
uniprot id: Q4R362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9541:CNPY2
gene id: 9541:CNPY2
uniprot id: A0A2K5WDB9
names: Similarity
messages: Belongs to the canopy family.

9541:CTSZ
gene id: 9541:CTSZ
uniprot id: A0A2K5U716
names: Similarity
messages: Belongs to the peptidase C1 family.

9541:SLC39A7
gene id: 9541:SLC39A7
uniprot id: A0A8J8Y167
uniprot id: G7P2S2
names: Subcellular Location Annotation
messages: Membrane

9541:LTA4H
gene id: 9541:LTA4H
uniprot id: A0A2K5U9C9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9541:INSM2
gene id: 9541:INSM2
uniprot id: A0A2K5UEF6
names: Subcellular Location Annotation
messages: Nucleus

9541:SCG5
gene id: 9541:SCG5
uniprot id: Q2PFP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9541:RPTOR
gene id: 9541:RPTOR
uniprot id: A0A2K5TPP8
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

9541:FUT10
gene id: 9541:FUT10
uniprot id: A0A2K5UAV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9541:SCAMP3
gene id: 9541:SCAMP3
uniprot id: A0A2K5V3C2
uniprot id: A0A2K5V3F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9541:ORC4
gene id: 9541:ORC4
uniprot id: A0A7N9CQ05
uniprot id: A0A8J8XCG5
uniprot id: G7PKJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9541:FAM135A
gene id: 9541:FAM135A
uniprot id: A0A2K5TX22
uniprot id: A0A7N9DGC9
names: Similarity
messages: Belongs to the FAM135 family.

9541:NAE1
gene id: 9541:NAE1
uniprot id: Q4R3L6
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity.
messages: Cell membrane
messages: Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2 (By similarity).
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity). The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development.
messages: Ubiquitinated by TRIP12, leading to its degradation by the proteasome.

9541:IP6K1
gene id: 9541:IP6K1
uniprot id: A0A2K5TSG4
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9541:NPM3
gene id: 9541:NPM3
uniprot id: A0A8J8XAZ9
uniprot id: G7PDT5
names: Similarity
messages: Belongs to the nucleoplasmin family.

9541:POLR3B
gene id: 9541:POLR3B
uniprot id: A0A8J8YGM6
uniprot id: G7PI40
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9541:TRAP1
gene id: 9541:TRAP1
uniprot id: A0A2K5WV36
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9541:RNF31
gene id: 9541:RNF31
uniprot id: A0A8J8Y808
uniprot id: G7P9X8
names: Similarity
messages: Belongs to the RBR family.

9541:SEC61G
gene id: 9541:SEC61G
uniprot id: A0A2K5X404
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:WDR35
gene id: 9541:WDR35
uniprot id: A0A2K5WG25
uniprot id: A0A2K5WG69
names: Function
names: Subcellular Location Annotation
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: centrosome
messages: cilium basal body

9541:EPHB6
gene id: 9541:EPHB6
uniprot id: A0A2K5X5C5
names: Subcellular Location Annotation
messages: Membrane

9541:PSMA1
gene id: 9541:PSMA1
uniprot id: A0A2K5W387
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9541:LOC102122418
gene id: 9541:LOC102122418
uniprot id: A0A2K5U3G2
names: Subcellular Location Annotation
messages: Membrane

9541:HOXA6
gene id: 9541:HOXA6
uniprot id: A0A8J8YSD7
uniprot id: G7P0P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9541:LOC102141219
gene id: 9541:LOC102141219
uniprot id: A0A2K5UIS1
uniprot id: G8F2Z1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:EXOC2
gene id: 9541:EXOC2
uniprot id: A0A2K5VSX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9541:TSSC4
gene id: 9541:TSSC4
uniprot id: A0A2K5X637
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TSSC4 family.
messages: Cytoplasm
messages: Nucleus

9541:CCNDBP1
gene id: 9541:CCNDBP1
uniprot id: A0A7N9DA24
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

9541:BRINP1
gene id: 9541:BRINP1
uniprot id: A0A8J8YF47
uniprot id: G7PRK2
names: Similarity
messages: Belongs to the BRINP family.

9541:LOC101867398
gene id: 9541:LOC101867398
uniprot id: A0A7N9CGS2
names: Similarity
messages: Belongs to the peptidase M67C family.

9541:TAS2R16
gene id: 9541:TAS2R16
uniprot id: A0A7N9CVE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:CNN1
gene id: 9541:CNN1
uniprot id: G7PZF6
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9541:TUBA4A
gene id: 9541:TUBA4A
uniprot id: P68367
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
messages: Although this tubulin does not encode a C-terminal tyrosine, a C-terminal tyrosine can be added post-translationally by the tubulin tyrosine ligase (TTL). It can then undergo a detyrosination cycle by the tubulin tyrosine carboxypeptidase (KIAA0895L/MATCAP).
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with CFAP157 (By similarity).
messages: Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.
messages: The MREC motif may be critical for tubulin autoregulation.
messages: This tubulin does not have a C-terminal tyrosine.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9541:MRPL11
gene id: 9541:MRPL11
uniprot id: A0A8J8XSM2
uniprot id: G7PP94
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9541:LOC102128179
gene id: 9541:LOC102128179
uniprot id: A0A8J8XL53
uniprot id: G7P5Z2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ZKSCAN8
gene id: 9541:ZKSCAN8
uniprot id: A0A8J8XTZ8
uniprot id: G7P3S3
names: Subcellular Location Annotation
messages: Nucleus

9541:PPP1R3C
gene id: 9541:PPP1R3C
uniprot id: A0A2K5X6W1
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9541:ADGRL3
gene id: 9541:ADGRL3
uniprot id: A0A2K5X4I3
uniprot id: A0A2K5X4J3
names: Subcellular Location Annotation
messages: Membrane

9541:EXOC6
gene id: 9541:EXOC6
uniprot id: A0A7N9CLZ1
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9541:RBM47
gene id: 9541:RBM47
uniprot id: A0A2K5WK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Cytoplasm
messages: Nucleus

9541:AXIN2
gene id: 9541:AXIN2
uniprot id: A0A2K5TM28
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SPIC
gene id: 9541:SPIC
uniprot id: A0A2K5WBK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:KCNAB2
gene id: 9541:KCNAB2
uniprot id: A0A2K5V8Z8
uniprot id: A0A7N9DCB8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Monomer.
messages: axon
messages: cytoskeleton
messages: synaptosome

9541:SLC6A16
gene id: 9541:SLC6A16
uniprot id: G7PY67
names: Subcellular Location Annotation
messages: Membrane

9541:TOR3A
gene id: 9541:TOR3A
uniprot id: A0A2K5WW44
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9541:NUCB2
gene id: 9541:NUCB2
uniprot id: A0A2K5WKW3
names: Similarity
messages: Belongs to the nucleobindin family.

9541:JRK
gene id: 9541:JRK
uniprot id: G7PD20
names: Subcellular Location Annotation
messages: Nucleus

9541:PGGT1B
gene id: 9541:PGGT1B
uniprot id: A0A2K5WTH1
uniprot id: G7P826
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9541:NANOS2
gene id: 9541:NANOS2
uniprot id: A0A8J8XQ98
uniprot id: G7PXX8
names: Similarity
messages: Belongs to the nanos family.

9541:LOC102134569
gene id: 9541:LOC102134569
uniprot id: A0A2K5UQZ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9541:TSFM
gene id: 9541:TSFM
uniprot id: A0A2K5U4Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

9541:FABP5
gene id: 9541:FABP5
uniprot id: A0A2K5VFN5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:NINJ2
gene id: 9541:NINJ2
uniprot id: A0A2K5UDG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9541:UPK1B
gene id: 9541:UPK1B
uniprot id: A0A8J8YPH5
uniprot id: G7NXN2
names: Subcellular Location Annotation
messages: Membrane

9541:KCNK1
gene id: 9541:KCNK1
uniprot id: A0A2K5WVY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9541:TBXAS1
gene id: 9541:TBXAS1
uniprot id: A0A2K5UH73
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:STXBP5L
gene id: 9541:STXBP5L
uniprot id: A0A2K5U0F5
uniprot id: A0A2K5U0G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9541:TMEM167A
gene id: 9541:TMEM167A
uniprot id: A0A7N9DD82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

9541:ACTA2
gene id: 9541:ACTA2
uniprot id: A0A2K5U1C8
names: Similarity
messages: Belongs to the actin family.

9541:A4GNT
gene id: 9541:A4GNT
uniprot id: A0A2K5VVL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9541:GPM6B
gene id: 9541:GPM6B
uniprot id: A0A2K5WHV9
uniprot id: G7Q290
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9541:NAP1L2
gene id: 9541:NAP1L2
uniprot id: G8F2R5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9541:ENY2
gene id: 9541:ENY2
uniprot id: A0A2K5VMX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9541:SPATA6
gene id: 9541:SPATA6
uniprot id: A0A2K5U5E4
names: Similarity
messages: Belongs to the SPATA6 family.

9541:B3GNT8
gene id: 9541:B3GNT8
uniprot id: A0A2K5UK06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:INTS8
gene id: 9541:INTS8
uniprot id: A0A2K5U6S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9541:CDH18
gene id: 9541:CDH18
uniprot id: A0A2K5UPM6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:INO80
gene id: 9541:INO80
uniprot id: A0A2K5VMV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9541:CKMT2
gene id: 9541:CKMT2
uniprot id: G7P7V7
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9541:CDK10
gene id: 9541:CDK10
uniprot id: A0A2K5X3L2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:SYNDIG1L
gene id: 9541:SYNDIG1L
uniprot id: A0A2K5WYG8
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:PLA2G12A
gene id: 9541:PLA2G12A
uniprot id: A0A2K5TPG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

9541:GSTO2
gene id: 9541:GSTO2
uniprot id: A0A023JBX8
uniprot id: A0A2K5TM32
uniprot id: A0A8J8Y1F3
uniprot id: G7PDX3
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9541:SPEM1
gene id: 9541:SPEM1
uniprot id: A0A2K5WTV9
names: Subcellular Location Annotation
messages: Membrane

9541:HSBP1
gene id: 9541:HSBP1
uniprot id: Q4R7N4
names: Similarity
messages: Belongs to the HSBP1 family.

9541:LMX1B
gene id: 9541:LMX1B
uniprot id: A0A2K5TQ26
names: Subcellular Location Annotation
messages: Nucleus

9541:ERC2
gene id: 9541:ERC2
uniprot id: A0A7N9D4D1
names: Subcellular Location Annotation
messages: Cytoplasm

9541:NR6A1
gene id: 9541:NR6A1
uniprot id: A0A2K5VTJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:NXPH2
gene id: 9541:NXPH2
uniprot id: A0A2K5X3I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9541:KCTD16
gene id: 9541:KCTD16
uniprot id: A0A2K5UWN2
names: Subcellular Location Annotation
messages: Cell membrane

9541:IRF6
gene id: 9541:IRF6
uniprot id: A0A2K5X5G7
uniprot id: A0A8J8XYR9
names: Subcellular Location Annotation
messages: Nucleus

9541:RBP2
gene id: 9541:RBP2
uniprot id: A0A8J8XRQ6
uniprot id: G7P027
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:DCPS
gene id: 9541:DCPS
uniprot id: A0A7N9CFJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9541:SLC1A2
gene id: 9541:SLC1A2
uniprot id: A0A2K5VEU4
uniprot id: A0A2K5VEW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9541:GPR171
gene id: 9541:GPR171
uniprot id: A0A2K5US76
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:TEKT3
gene id: 9541:TEKT3
uniprot id: A0A8J8YPQ6
uniprot id: G7PTQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9541:GIMAP8
gene id: 9541:GIMAP8
uniprot id: A0A8J8YKR5
uniprot id: G7P201
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9541:CDC42EP4
gene id: 9541:CDC42EP4
uniprot id: I7GEW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9541:PITX2
gene id: 9541:PITX2
uniprot id: A0A2K5X5I0
uniprot id: A0A2K5X5L8
uniprot id: A0A2K5X624
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9541:UCP3
gene id: 9541:UCP3
uniprot id: A0A2K5U8E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:STARD3NL
gene id: 9541:STARD3NL
uniprot id: A0A2K5VI54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Membrane

9541:MRGPRF
gene id: 9541:MRGPRF
uniprot id: I7GAT0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:UTP3
gene id: 9541:UTP3
uniprot id: A0A2K5UFL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

9541:MX2
gene id: 9541:MX2
uniprot id: A0A2K5WSV3
uniprot id: A0A8J8XMP4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9541:GLUL
gene id: 9541:GLUL
uniprot id: A0A7N9CVE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Membrane
messages: Microsome
messages: Mitochondrion

9541:TMEM14B
gene id: 9541:TMEM14B
uniprot id: A0A2K5VR38
names: Similarity
messages: Belongs to the TMEM14 family.

9541:MON1A
gene id: 9541:MON1A
uniprot id: Q95KG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MON1/SAND family.
messages: Interacts with CCZ1 (By similarity). Found in a complex with RMC1, CCZ1, MON1A and MON1B (By similarity). The MON1A-CCZ1B complex interacts with RIMOC1 (By similarity). The MON1A-CCZ1B complex interacts with RAB7A and this interaction is enhanced in the presence of RIMOC1 (By similarity).
messages: Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form.

9541:RNASE1
gene id: 9541:RNASE1
uniprot id: A0A8J8XAJ9
uniprot id: G7P9M4
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:MAP1LC3B
gene id: 9541:MAP1LC3B
uniprot id: A0A7N9C6Y1
names: Similarity
messages: Belongs to the ATG8 family.

9541:POP7
gene id: 9541:POP7
uniprot id: A0A8J8XVN3
uniprot id: G7P0D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9541:RNF20
gene id: 9541:RNF20
uniprot id: A0A2K5WX05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9541:MCTP2
gene id: 9541:MCTP2
uniprot id: A0A2K5VJI3
names: Subcellular Location Annotation
messages: Membrane

9541:PARP3
gene id: 9541:PARP3
uniprot id: A0A2K5V4Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9541:ARF3
gene id: 9541:ARF3
uniprot id: A0A7N9CGG1
uniprot id: G8F594
uniprot id: Q2PG54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9541:RBKS
gene id: 9541:RBKS
uniprot id: A0A8J8XKD9
uniprot id: G7PLX7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9541:NXF3
gene id: 9541:NXF3
uniprot id: A0A2K5VUK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

9541:PARK7
gene id: 9541:PARK7
uniprot id: A0A2K5VY13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9541:LOC102133631
gene id: 9541:LOC102133631
uniprot id: A0A7N9CTH0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9541:MGAT4B
gene id: 9541:MGAT4B
uniprot id: A0A2K5UN73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane

9541:KALRN
gene id: 9541:KALRN
uniprot id: A0A2K5VIL2
uniprot id: A0A2K5VJC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm

9541:FAM229B
gene id: 9541:FAM229B
uniprot id: A5LFY3
uniprot id: G7P3M5
names: Similarity
messages: Belongs to the FAM229 family.

9541:VAT1L
gene id: 9541:VAT1L
uniprot id: A0A8J8YT23
uniprot id: G7Q1P8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9541:PNLIPRP3
gene id: 9541:PNLIPRP3
uniprot id: A0A2K5URK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9541:PPIP5K2
gene id: 9541:PPIP5K2
uniprot id: A0A2K5UZZ2
uniprot id: A0A2K5UZZ9
uniprot id: A0A2K5V029
uniprot id: A0A8J8Y795
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9541:LOC102121517
gene id: 9541:LOC102121517
uniprot id: G7P2N0
uniprot id: Q4R362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9541:MRRF
gene id: 9541:MRRF
uniprot id: A0A2K5VLI5
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9541:ZNF483
gene id: 9541:ZNF483
uniprot id: A0A2K5UVJ3
uniprot id: G8F3G3
names: Subcellular Location Annotation
messages: Nucleus

9541:APOC2
gene id: 9541:APOC2
uniprot id: A2V9Y5
uniprot id: P18658
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.
messages: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
messages: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
messages: Secreted

9541:CACNA1D
gene id: 9541:CACNA1D
uniprot id: A0A2K5X3X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9541:ELF2
gene id: 9541:ELF2
uniprot id: A0A2K5W1K2
uniprot id: A0A2K5W1M3
uniprot id: A0A7N9IDC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:NSF
gene id: 9541:NSF
uniprot id: A0A2K5V7I5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9541:HBM
gene id: 9541:HBM
uniprot id: A0A2K5W0M5
names: Similarity
messages: Belongs to the globin family.

9541:PUS3
gene id: 9541:PUS3
uniprot id: A0A2K5TSS2
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9541:MEIS1
gene id: 9541:MEIS1
uniprot id: A0A2K5U2L5
uniprot id: A0A2K5U2L9
uniprot id: A0A2K5U2N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9541:SRP54
gene id: 9541:SRP54
uniprot id: A0A8J8Y7F2
uniprot id: G7PA28
uniprot id: Q4R965
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity).
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity).
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

9541:MPZ
gene id: 9541:MPZ
uniprot id: A0A2K5TVH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Homodimer and homotetramer.
messages: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
messages: Membrane

9541:RSPO1
gene id: 9541:RSPO1
uniprot id: A0A2K5VIC7
names: Similarity
messages: Belongs to the R-spondin family.

9541:C18H18orf25
gene id: 9541:C18H18orf25
uniprot id: A0A2K5VZE1
uniprot id: A0A8J8YLS4
uniprot id: G7PWQ4
names: Subcellular Location Annotation
messages: Nucleus

9541:CHMP2B
gene id: 9541:CHMP2B
uniprot id: A0A8J8XYL2
uniprot id: G7NZ52
names: Similarity
messages: Belongs to the SNF7 family.

9541:DEFA6
gene id: 9541:DEFA6
uniprot id: A0A8J8YGN9
uniprot id: G7PCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9541:DENND6A
gene id: 9541:DENND6A
uniprot id: A0A2K5VAS5
uniprot id: A0A7N9CTT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

9541:SPPL3
gene id: 9541:SPPL3
uniprot id: A0A2K5W529
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9541:B4GALT6
gene id: 9541:B4GALT6
uniprot id: A0A2K5V5W8
uniprot id: A0A2K5V5Z4
uniprot id: A0A8J8Y1F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9541:LOC102142948
gene id: 9541:LOC102142948
uniprot id: G7NZ60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:SCFD2
gene id: 9541:SCFD2
uniprot id: A0A2K5VZ06
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9541:SP4
gene id: 9541:SP4
uniprot id: A0A2K5WI63
names: Subcellular Location Annotation
messages: Nucleus

9541:PTPN6
gene id: 9541:PTPN6
uniprot id: A0A2K5V7T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9541:WSCD2
gene id: 9541:WSCD2
uniprot id: A0A2K5TJL6
names: Function
names: Similarity
messages: Belongs to the WSCD family.
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9541:TAX1BP3
gene id: 9541:TAX1BP3
uniprot id: I7GLD5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9541:WASF2
gene id: 9541:WASF2
uniprot id: A0A2K5U8K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9541:PFKFB1
gene id: 9541:PFKFB1
uniprot id: A0A2K5V950
uniprot id: G7Q2U3
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9541:JAK1
gene id: 9541:JAK1
uniprot id: A0A2K5WAH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system

9541:SEC62
gene id: 9541:SEC62
uniprot id: A0A8J8Y6F9
uniprot id: G7NZF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:ESCO2
gene id: 9541:ESCO2
uniprot id: A0A2K5VNS5
names: Subcellular Location Annotation
messages: Nucleus

9541:FAM214B
gene id: 9541:FAM214B
uniprot id: A0A2K5VGE7
uniprot id: Q4R676
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus
messages: The protein contains a transactivation domain (TAD) which may be required for transcriptional activation of a subset of target genes.
messages: Transcription regulator that may syncronize transcriptional and translational programs.

9541:KCND2
gene id: 9541:KCND2
uniprot id: A0A2K5WRY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9541:SUPT20H
gene id: 9541:SUPT20H
uniprot id: A0A2K5UYT4
uniprot id: A0A2K5UYW4
names: Similarity
messages: Belongs to the SPT20 family.

9541:PRDM10
gene id: 9541:PRDM10
uniprot id: A0A2K5UT82
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:IL13RA1
gene id: 9541:IL13RA1
uniprot id: A0A7N9D0M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.
messages: Membrane

9541:ESS2
gene id: 9541:ESS2
uniprot id: A0A2K5W123
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9541:RRP8
gene id: 9541:RRP8
uniprot id: A0A2K5WRH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: nucleolus

9541:EDN2
gene id: 9541:EDN2
uniprot id: G7NUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9541:LIX1
gene id: 9541:LIX1
uniprot id: A0A2K5U7H8
names: Similarity
messages: Belongs to the LIX1 family.

9541:GNA11
gene id: 9541:GNA11
uniprot id: A0A2K5WV53
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9541:PPP1R12A
gene id: 9541:PPP1R12A
uniprot id: A0A2K5WH94
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9541:RPS18
gene id: 9541:RPS18
uniprot id: A0A2K5V0I8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.

9541:LOC102121548
gene id: 9541:LOC102121548
uniprot id: A0A2K5TQ29
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9541:PTGER3
gene id: 9541:PTGER3
uniprot id: A0A2K5TLN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:TMOD3
gene id: 9541:TMOD3
uniprot id: A0A2K5TWU7
names: Subcellular Location Annotation
messages: cytoskeleton

9541:SYF2
gene id: 9541:SYF2
uniprot id: A0A8J8YSR6
uniprot id: G7NVW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

9541:ICAM2
gene id: 9541:ICAM2
uniprot id: A0A2K5WE44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9541:GOLM2
gene id: 9541:GOLM2
uniprot id: A0A2K5UP08
uniprot id: A0A2K5UP24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9541:KLC4
gene id: 9541:KLC4
uniprot id: A0A2K5WL84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9541:NSMCE4A
gene id: 9541:NSMCE4A
uniprot id: A0A2K5X6C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

9541:APOLD1
gene id: 9541:APOLD1
uniprot id: A0A7N9CPN4
names: Similarity
messages: Belongs to the apolipoprotein L family.

9541:RXRG
gene id: 9541:RXRG
uniprot id: A0A8J8XR23
uniprot id: G7NU27
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9541:KEG98 p13
gene id: 9541:KEG98_p13
uniprot id: C3W4Y5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9541:NDFIP1
gene id: 9541:NDFIP1
uniprot id: A0A2K5X3P9
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9541:CLK4
gene id: 9541:CLK4
uniprot id: A0A2K5X0K8
uniprot id: A0A7N9CE55
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:WNT9B
gene id: 9541:WNT9B
uniprot id: A0A7N9DG84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:DLK2
gene id: 9541:DLK2
uniprot id: A0A2K5TSZ3
uniprot id: G8F4F1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:EGR2
gene id: 9541:EGR2
uniprot id: G7PDE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9541:DPY19L3
gene id: 9541:DPY19L3
uniprot id: A0A2K5VH86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9541:CDH1
gene id: 9541:CDH1
uniprot id: A0A2K5V299
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:HNMT
gene id: 9541:HNMT
uniprot id: A0A2K5VBJ8
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9541:SPACA4
gene id: 9541:SPACA4
uniprot id: G7PY25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9541:PIGF
gene id: 9541:PIGF
uniprot id: A0A2K5VGY5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:CFAP126
gene id: 9541:CFAP126
uniprot id: A0A2K5TRH1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9541:RABGGTB
gene id: 9541:RABGGTB
uniprot id: A0A2K5WEG7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9541:CLIC1
gene id: 9541:CLIC1
uniprot id: A0A7N9CK20
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9541:FAM126B
gene id: 9541:FAM126B
uniprot id: A0A2K5V065
uniprot id: G7PL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9541:COQ10A
gene id: 9541:COQ10A
uniprot id: A0A2K5UKY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9541:POLR2F
gene id: 9541:POLR2F
uniprot id: A0A2K5U2B7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9541:LOC102116629
gene id: 9541:LOC102116629
uniprot id: A0A2K5WRG3
uniprot id: A0A8J8XC80
names: Similarity
messages: Belongs to the SUI1 family.

9541:ORMDL3
gene id: 9541:ORMDL3
uniprot id: A0A8J8XRK2
uniprot id: G7PUM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9541:MPP4
gene id: 9541:MPP4
uniprot id: A0A2K5WL68
names: Similarity
messages: Belongs to the MAGUK family.

9541:PTPN4
gene id: 9541:PTPN4
uniprot id: A0A2K5W4U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9541:ALDH9A1
gene id: 9541:ALDH9A1
uniprot id: A0A2K5V7N6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:MYH11
gene id: 9541:MYH11
uniprot id: A0A2K5W527
uniprot id: A0A2K5W551
uniprot id: A0A2K5W599
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:KCNK2
gene id: 9541:KCNK2
uniprot id: A0A2K5TJU3
uniprot id: A0A2K5TJU7
uniprot id: A0A8J8YP25
uniprot id: G7NTZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9541:SPCS3
gene id: 9541:SPCS3
uniprot id: A0A2K5U7I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:PAX3
gene id: 9541:PAX3
uniprot id: A0A2K5V1D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9541:PCYT1A
gene id: 9541:PCYT1A
uniprot id: A0A7N9CXD5
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9541:PTHLH
gene id: 9541:PTHLH
uniprot id: A0A2K5W832
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9541:ZIC1
gene id: 9541:ZIC1
uniprot id: A0A2K5TMG3
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9541:LOC102115644
gene id: 9541:LOC102115644
uniprot id: A0A2K5WP84
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9541:SYK
gene id: 9541:SYK
uniprot id: A0A2K5V796
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9541:DPH3
gene id: 9541:DPH3
uniprot id: G7NY17
uniprot id: Q4R312
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH3 family.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase (By similarity). Interacts with SERGEF (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
messages: The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.

9541:GPR137
gene id: 9541:GPR137
uniprot id: A0A7N9CBZ7
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9541:TMEM218
gene id: 9541:TMEM218
uniprot id: A0A2K5VBS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9541:TERF1
gene id: 9541:TERF1
uniprot id: A0A2K5X903
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

9541:GDPGP1
gene id: 9541:GDPGP1
uniprot id: A0A2K5UIS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9541:HAPLN1
gene id: 9541:HAPLN1
uniprot id: A0A2K5VFA9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TMTC2
gene id: 9541:TMTC2
uniprot id: A0A2K5WKT3
uniprot id: A0A8J8XP16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9541:TFIP11
gene id: 9541:TFIP11
uniprot id: A0A2K5VFC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9541:IRF3
gene id: 9541:IRF3
uniprot id: A0A2K5V5R1
uniprot id: G8F5X0
names: Subcellular Location Annotation
messages: Nucleus

9541:YIPF4
gene id: 9541:YIPF4
uniprot id: A0A8J8XRH1
uniprot id: G7PLZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:AHSA1
gene id: 9541:AHSA1
uniprot id: A0A8J8YKD1
uniprot id: G7PB34
names: Similarity
messages: Belongs to the AHA1 family.

9541:NIPA2
gene id: 9541:NIPA2
uniprot id: A0A2K5U1N2
uniprot id: A0A8J8XR58
uniprot id: G7PAF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9541:RPS29
gene id: 9541:RPS29
uniprot id: A0A2K5WR94
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9541:RETNLB
gene id: 9541:RETNLB
uniprot id: A0A7N9CMW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9541:TRAPPC1
gene id: 9541:TRAPPC1
uniprot id: A0A8J8YRK2
uniprot id: G7PTJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9541:MAOB
gene id: 9541:MAOB
uniprot id: A0A2K5TQG7
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9541:NHP2
gene id: 9541:NHP2
uniprot id: A0A8J8XS32
uniprot id: G7P715
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9541:SYNGR4
gene id: 9541:SYNGR4
uniprot id: A0A2K5WFX6
uniprot id: A0A2K5WG58
uniprot id: G8F5G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9541:CUL4A
gene id: 9541:CUL4A
uniprot id: A0A2K5VIT2
names: Similarity
messages: Belongs to the cullin family.

9541:BRINP3
gene id: 9541:BRINP3
uniprot id: A0A2K5TNH3
names: Similarity
messages: Belongs to the BRINP family.

9541:LOC102131904
gene id: 9541:LOC102131904
uniprot id: A0A2K5V8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat fritz family.
messages: Cell membrane
messages: Membrane
messages: cilium axoneme

9541:LUC7L3
gene id: 9541:LUC7L3
uniprot id: A0A2K5UY02
uniprot id: A0A2K5UY32
uniprot id: G7PUB4
names: Similarity
messages: Belongs to the Luc7 family.

9541:ANKRD13C
gene id: 9541:ANKRD13C
uniprot id: A0A2K5TT21
names: Subcellular Location Annotation
messages: Membrane

9541:INO80D
gene id: 9541:INO80D
uniprot id: A0A2K5TUN5
names: Subcellular Location Annotation
messages: Nucleus

9541:SDHD
gene id: 9541:SDHD
uniprot id: A0A2K5VD68
uniprot id: A0A8J8XED5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9541:FAM126A
gene id: 9541:FAM126A
uniprot id: A0A2K5ULI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9541:FICD
gene id: 9541:FICD
uniprot id: A0A8J8Y0R5
uniprot id: G7PI52
names: Similarity
messages: Belongs to the fic family.

9541:TES
gene id: 9541:TES
uniprot id: A0A2K5UCY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: focal adhesion

9541:DIABLO
gene id: 9541:DIABLO
uniprot id: I7GJM7
names: Subcellular Location Annotation
messages: Mitochondrion

9541:C11H12orf57
gene id: 9541:C11H12orf57
uniprot id: A0A7N9IC88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

9541:WWOX
gene id: 9541:WWOX
uniprot id: A0A2K5W5D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Lysosome
messages: Mitochondrion

9541:SEPTIN8
gene id: 9541:SEPTIN8
uniprot id: I7GH31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:TRIM32
gene id: 9541:TRIM32
uniprot id: A0A8J8YEP3
uniprot id: G7PRK5
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9541:ARPC4
gene id: 9541:ARPC4
uniprot id: A0A2K5WPR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9541:CLDN1
gene id: 9541:CLDN1
uniprot id: A0A2K5WWF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:B4GALNT2
gene id: 9541:B4GALNT2
uniprot id: A0A2K5WB01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

9541:UGP2
gene id: 9541:UGP2
uniprot id: A0A2K5VCA2
uniprot id: A0A2K5VCC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9541:COG4
gene id: 9541:COG4
uniprot id: A0A2K5V3G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9541:CBX3
gene id: 9541:CBX3
uniprot id: A0A2K5X776
names: Subcellular Location Annotation
messages: Nucleus

9541:PYCR2
gene id: 9541:PYCR2
uniprot id: Q4R6W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Cytoplasm
messages: Homodecamer; composed of 5 homodimers. Interacts with LTO1.
messages: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity).
messages: Mitochondrion

9541:LOC102122758
gene id: 9541:LOC102122758
uniprot id: A0A7N9I9L6
names: Similarity
messages: Belongs to the fl(2)d family.

9541:NT5C2
gene id: 9541:NT5C2
uniprot id: A0A8J8YBL1
uniprot id: G7PDV7
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9541:ERBB3
gene id: 9541:ERBB3
uniprot id: A0A8J8XF73
uniprot id: G7PIG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9541:METTL26
gene id: 9541:METTL26
uniprot id: A0A2K5UWP3
names: Similarity
messages: Belongs to the UPF0585 family.

9541:SLC26A2
gene id: 9541:SLC26A2
uniprot id: A0A2K5VCG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.

9541:LOC102125919
gene id: 9541:LOC102125919
uniprot id: A0A2K5W6B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9541:TRHR
gene id: 9541:TRHR
uniprot id: A0A2K5UTF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9541:MAB21L1
gene id: 9541:MAB21L1
uniprot id: A0A2K5TP07
names: Similarity
messages: Belongs to the mab-21 family.

9541:BCLAF1
gene id: 9541:BCLAF1
uniprot id: A0A2K5WXE7
uniprot id: A0A7N9IGT3
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9541:LOC102122430
gene id: 9541:LOC102122430
uniprot id: A0A2K5TR05
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:CPQ
gene id: 9541:CPQ
uniprot id: A0A2K5W7T5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. The monomeric form is inactive while the homodimer is active.
messages: Lysosome

9541:F9
gene id: 9541:F9
uniprot id: A0A8J8XCV8
uniprot id: G7Q1U2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:SCN1B
gene id: 9541:SCN1B
uniprot id: A0A2K5V251
names: Subcellular Location Annotation
messages: Membrane

9541:EMG1
gene id: 9541:EMG1
uniprot id: A0A8J8XFU7
uniprot id: G7PJP2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9541:KIF20A
gene id: 9541:KIF20A
uniprot id: A0A2K5WY13
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:PDGFC
gene id: 9541:PDGFC
uniprot id: A0A2K5V0S6
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RACK1
gene id: 9541:RACK1
uniprot id: A0A2K5VEN4
uniprot id: Q4R7Y4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with CPNE3 (By similarity). May interact with ABCB4 (By similarity). Component of the small (40S) ribosomal subunit. Exists as a monomer and also forms oligomers. Binds NHERF1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1. Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of RACK1. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1R but not with INSR. Interacts with ADAM12. Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation. Interacts with RHOA; this enhances RHOA activation and promotes cell migration. Interacts with CHRM2; the interaction regulates CHRM2 internalization. Interacts with TRPM6 (via kinase domain). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1. Interacts with HRAS. Interacts with LARP4B. Interacts with PKD2L1 (By similarity).
messages: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration (By similarity). Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity).
messages: Nucleus
messages: Perikaryon
messages: Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC (By similarity).
messages: dendrite
messages: perinuclear region

9541:RSBN1
gene id: 9541:RSBN1
uniprot id: A0A2K5X9Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9541:PPIL3
gene id: 9541:PPIL3
uniprot id: A0A2K5WNT8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9541:PTP4A3
gene id: 9541:PTP4A3
uniprot id: A0A8J8YRA9
uniprot id: G7PD16
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9541:ID3
gene id: 9541:ID3
uniprot id: A0A2K5VV86
names: Subcellular Location Annotation
messages: Nucleus

9541:C6H5orf24
gene id: 9541:C6H5orf24
uniprot id: G7P8B2
names: Similarity
messages: Belongs to the UPF0461 family.

9541:PTPN12
gene id: 9541:PTPN12
uniprot id: A0A2K5USI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

9541:NOL12
gene id: 9541:NOL12
uniprot id: A0A2K5UD50
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

9541:SPIN1
gene id: 9541:SPIN1
uniprot id: A0A2K5U068
uniprot id: A0A8J8XDI2
names: Similarity
messages: Belongs to the SPIN/STSY family.

9541:CADM2
gene id: 9541:CADM2
uniprot id: A0A2K5U0W6
uniprot id: A0A2K5U0X1
names: Similarity
messages: Belongs to the nectin family.

9541:PIK3CA
gene id: 9541:PIK3CA
uniprot id: A0A8J8XAB5
uniprot id: G7NZ32
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9541:FN1
gene id: 9541:FN1
uniprot id: A0A2K5V0E3
uniprot id: A0A2K5V0E4
uniprot id: A0A2K5V0I5
names: Function
messages: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.

9541:PDCL
gene id: 9541:PDCL
uniprot id: A0A2K5W0N3
names: Similarity
messages: Belongs to the phosducin family.

9541:LOC102123270
gene id: 9541:LOC102123270
uniprot id: G7P5I5
uniprot id: Q4R648
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9541:PTPRD
gene id: 9541:PTPRD
uniprot id: A0A2K5V177
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

9541:DNAJC27
gene id: 9541:DNAJC27
uniprot id: A0A7N9IHN1
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9541:DNAJC16
gene id: 9541:DNAJC16
uniprot id: A0A2K5X618
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

9541:SF3B4
gene id: 9541:SF3B4
uniprot id: A0A8J8Y0H7
uniprot id: G7NTS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9541:COPZ2
gene id: 9541:COPZ2
uniprot id: I7GJN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9541:TBC1D24
gene id: 9541:TBC1D24
uniprot id: A0A2K5VWN6
uniprot id: A0A2K5VWS7
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse

9541:PRMT5
gene id: 9541:PRMT5
uniprot id: A0A2K5U736
uniprot id: A0A2K5U799
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9541:ENDOU
gene id: 9541:ENDOU
uniprot id: A0A2K5TLU3
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

9541:XPA
gene id: 9541:XPA
uniprot id: A0A2K5TWB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9541:IL17A
gene id: 9541:IL17A
uniprot id: A0A2K5TTB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9541:PDE5A
gene id: 9541:PDE5A
uniprot id: A0A2K5U205
uniprot id: A0A2K5U243
uniprot id: A0A8J8Y3N4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:MAP3K12
gene id: 9541:MAP3K12
uniprot id: A0A2K5VJ06
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9541:STK38
gene id: 9541:STK38
uniprot id: A0A8J8YLB9
uniprot id: G7P3B9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:TMEM150B
gene id: 9541:TMEM150B
uniprot id: A0A8J8XUG3
uniprot id: G7PYY7
names: Subcellular Location Annotation
messages: Membrane

9541:PNKD
gene id: 9541:PNKD
uniprot id: A0A2K5TS50
uniprot id: I7G6D8
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9541:LRRTM3
gene id: 9541:LRRTM3
uniprot id: Q9BGP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRTM family.
messages: Cell membrane
messages: May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity).
messages: Postsynaptic cell membrane

9541:GABRE
gene id: 9541:GABRE
uniprot id: A0A2K5WCD4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:NFIB
gene id: 9541:NFIB
uniprot id: A0A2K5W5D7
uniprot id: G7PSC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9541:YTHDF3
gene id: 9541:YTHDF3
uniprot id: A0A2K5VFT2
uniprot id: A0A2K5VFV9
uniprot id: A0A2K5VFW1
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9541:PHF1
gene id: 9541:PHF1
uniprot id: G7P2T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9541:MS4A8
gene id: 9541:MS4A8
uniprot id: A0A2K5TY64
names: Similarity
messages: Belongs to the MS4A family.

9541:ADAT2
gene id: 9541:ADAT2
uniprot id: A0A8J8XYR1
uniprot id: G7P308
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Cytoplasm
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9541:SEPTIN12
gene id: 9541:SEPTIN12
uniprot id: A0A8J8YJG8
uniprot id: G7Q0E9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:DEFB110
gene id: 9541:DEFB110
uniprot id: A0A2K5VRP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:GAB1
gene id: 9541:GAB1
uniprot id: A0A8J8XW79
uniprot id: G7P6C4
names: Similarity
messages: Belongs to the GAB family.

9541:AP1B1
gene id: 9541:AP1B1
uniprot id: A0A2K5X0N0
uniprot id: A0A2K5X0Q6
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9541:TAS2R1
gene id: 9541:TAS2R1
uniprot id: A0A2K5WUY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:ZUP1
gene id: 9541:ZUP1
uniprot id: A0A2K5U8Z7
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9541:RGS2
gene id: 9541:RGS2
uniprot id: A0A8J8Y2I1
uniprot id: G7NXE1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: nucleolus

9541:NPL
gene id: 9541:NPL
uniprot id: A0A2K5WFI8
uniprot id: A0A8J8XEN5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9541:GUCA2B
gene id: 9541:GUCA2B
uniprot id: A0A8J8YK19
uniprot id: G7NUE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9541:LIPM
gene id: 9541:LIPM
uniprot id: A0A2K5U9C7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9541:RAB18
gene id: 9541:RAB18
uniprot id: A0A2K5UD45
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9541:SNRPG
gene id: 9541:SNRPG
uniprot id: A0A2K5WTS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9541:VBP1
gene id: 9541:VBP1
uniprot id: A0A2K5UZS6
uniprot id: A0A8J8XUR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9541:LIN7C
gene id: 9541:LIN7C
uniprot id: A0A2K5VUH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9541:SARS1
gene id: 9541:SARS1
uniprot id: Q4R4U9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule may bind across the dimer. Interacts with SIRT2. Interacts with METTL6; interaction is required for the tRNA N(3)-methylcytidine methyltransferase activity of METTL6.
messages: Nucleus

9541:CFAP97D1
gene id: 9541:CFAP97D1
uniprot id: A0A2K5U8Q6
names: Similarity
messages: Belongs to the CFAP97 family.

9541:MRPS17
gene id: 9541:MRPS17
uniprot id: A0A7N9CHQ5
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9541:KIT
gene id: 9541:KIT
uniprot id: A0A2K5U4C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9541:SEC11C
gene id: 9541:SEC11C
uniprot id: A0A8J8YDW3
uniprot id: G7PWV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:TACR3
gene id: 9541:TACR3
uniprot id: A0A2K5X9Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:AP1S3
gene id: 9541:AP1S3
uniprot id: A0A2K5X3W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9541:COPS8
gene id: 9541:COPS8
uniprot id: A0A8J8XCZ2
uniprot id: G7PKD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9541:SLC25A27
gene id: 9541:SLC25A27
uniprot id: A0A7N9D3Z0
uniprot id: A0A8J8YFY2
uniprot id: G7P4S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:CSGALNACT2
gene id: 9541:CSGALNACT2
uniprot id: A0A2K5UHW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9541:SLC39A10
gene id: 9541:SLC39A10
uniprot id: G7PL28
names: Subcellular Location Annotation
messages: Membrane

9541:CACYBP
gene id: 9541:CACYBP
uniprot id: Q4R4P3
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 (By similarity). Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity).
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).
messages: Nucleus
messages: Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations (By similarity).

9541:GALE
gene id: 9541:GALE
uniprot id: A0A8J8XC21
uniprot id: Q4R651
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9541:AUH
gene id: 9541:AUH
uniprot id: A0A2K5WCU2
uniprot id: A0A2K5WCX1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9541:RFTN2
gene id: 9541:RFTN2
uniprot id: A0A2K5W7N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9541:TM9SF3
gene id: 9541:TM9SF3
uniprot id: A0A2K5W768
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9541:NUP50
gene id: 9541:NUP50
uniprot id: A0A8J8YJC8
uniprot id: Q4R414
names: Subcellular Location Annotation
messages: nuclear pore complex

9541:DYNLL1
gene id: 9541:DYNLL1
uniprot id: A0A8J8Y705
uniprot id: G7PJ46
uniprot id: P61273
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1.
messages: Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944'). Interacts with BICD2. Interacts with BCAS1. Interacts with Bassoon/BSN (By similarity). Interacts with HDAC6 (By similarity). Interacts with TPPP (By similarity). Interacts with AMBRA1 (via TQT motifs); tethering AMBRA1 to the cytoskeleton (By similarity). Interacts with FAM83D/CHICA (via C-terminus) (By similarity). Interacts with HMMR, SPAG5/Astrin and KNSTRN/Kinastrin (By similarity). Interacts with TLK2 (By similarity). Interacts with NOS1 (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylation at Ser-88 appears to control the dimer-monomer transition.
messages: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
messages: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity).
messages: centrosome
messages: cytoskeleton

9541:TP53
gene id: 9541:TP53
uniprot id: G7PTI9
uniprot id: P56423
names: Cofactor
names: Disease Annotation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Acetylation of Lys-382 by EP300. Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-381 increases stability. Deacetylation at Lys-381 by SIRT6 decreases its stability, thereby regulating cell senescence.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interactio…
messages: Mitochondrion matrix
messages: Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).
messages: Nucleus
messages: PML body
messages: Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter (By similarity). Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Thr-55 by TAF1 which promotes MDM2-mediated TP53 degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).
messages: Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9 (By similarity).
messages: Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation. Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity).
messages: Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (By similarity).
messages: centrosome
messages: p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.

9541:SIGMAR1
gene id: 9541:SIGMAR1
uniprot id: A0A2K5VK98
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle
messages: growth cone

9541:KCNAB1
gene id: 9541:KCNAB1
uniprot id: A0A2K5V0E9
uniprot id: A0A2K5V0F2
uniprot id: A0A2K5V0K6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Monomer.

9541:TBK1
gene id: 9541:TBK1
uniprot id: A0A2K5UYJ5
names: Subcellular Location Annotation
messages: Cytoplasm

9541:AKT3
gene id: 9541:AKT3
uniprot id: A0A2K5V8I8
uniprot id: A0A8J8YC63
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9541:AMPD3
gene id: 9541:AMPD3
uniprot id: A0A2K5W9K5
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9541:OVCA2
gene id: 9541:OVCA2
uniprot id: G8F5I1
names: Similarity
messages: Belongs to the LovG family.

9541:MAT2B
gene id: 9541:MAT2B
uniprot id: A0A2K5VAN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9541:DLX1
gene id: 9541:DLX1
uniprot id: A0A8J8YK27
uniprot id: G7PKU0
names: Subcellular Location Annotation
messages: Nucleus

9541:THEMIS2
gene id: 9541:THEMIS2
uniprot id: A0A2K5URI2
names: Similarity
messages: Belongs to the themis family.

9541:XK
gene id: 9541:XK
uniprot id: A0A7N9CIT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9541:CUTA
gene id: 9541:CUTA
uniprot id: A0A2K5VJX9
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9541:PPM1K
gene id: 9541:PPM1K
uniprot id: A0A8J8YE78
uniprot id: G7P5W4
names: Similarity
messages: Belongs to the PP2C family.

9541:EIF3J
gene id: 9541:EIF3J
uniprot id: A0A2K5UTF1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9541:TADA2A
gene id: 9541:TADA2A
uniprot id: A0A2K5WT76
names: Subcellular Location Annotation
messages: Nucleus

9541:POLR2D
gene id: 9541:POLR2D
uniprot id: A0A2K5UYV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

9541:BFSP1
gene id: 9541:BFSP1
uniprot id: A0A2K5V913
uniprot id: A0A2K5V926
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

9541:LOC102127185
gene id: 9541:LOC102127185
uniprot id: A0A2K5VYJ1
uniprot id: A0A2K5VYL2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9541:VGLL4
gene id: 9541:VGLL4
uniprot id: A0A2K5UEN7
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9541:CADM1
gene id: 9541:CADM1
uniprot id: A0A2K5X0R3
uniprot id: A0A2K5X0R4
uniprot id: A0A2K5X0R9
uniprot id: A0A2K5X176
uniprot id: A0A2K5X1D0
names: Similarity
messages: Belongs to the nectin family.

9541:ZCCHC17
gene id: 9541:ZCCHC17
uniprot id: Q95KF9
names: Subcellular Location Annotation
names: Subunit
messages: May interact with PNN. May associate with the 60 S ribosomal subunit (By similarity).
messages: nucleolus

9541:C15H9orf64
gene id: 9541:C15H9orf64
uniprot id: A0A2K5WUN8
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

9541:MMP26
gene id: 9541:MMP26
uniprot id: A0A2K5WUI9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9541:NEK8
gene id: 9541:NEK8
uniprot id: A0A2K5WSY6
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9541:CCL24
gene id: 9541:CCL24
uniprot id: A0A7N9CBC6
names: Subcellular Location Annotation
messages: Secreted

9541:CD82
gene id: 9541:CD82
uniprot id: A0A2K5VAB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:HS2ST1
gene id: 9541:HS2ST1
uniprot id: A0A2K5VVH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:ACTL6A
gene id: 9541:ACTL6A
uniprot id: A0A2K5UP87
names: Similarity
messages: Belongs to the actin family.

9541:FBXO25
gene id: 9541:FBXO25
uniprot id: A0A2K5VTQ8
uniprot id: A0A8J8Y0Q7
uniprot id: G7PCB4
uniprot id: Q4R372
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus).
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).
messages: The F-box is necessary for the interaction with SKP1.

9541:FYN
gene id: 9541:FYN
uniprot id: A0A8J8XEI0
uniprot id: G7P3M8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:ADAMTS4
gene id: 9541:ADAMTS4
uniprot id: A0A2K5X742
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9541:DRD3
gene id: 9541:DRD3
uniprot id: A0A2K5W4P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9541:PDPR
gene id: 9541:PDPR
uniprot id: G7Q1M1
names: Similarity
messages: Belongs to the GcvT family.

9541:PCNX3
gene id: 9541:PCNX3
uniprot id: A0A2K5VMQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9541:TIE1
gene id: 9541:TIE1
uniprot id: A0A2K5W685
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:CTSK
gene id: 9541:CTSK
uniprot id: A0A805RTL9
uniprot id: P61276
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Secreted
messages: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

9541:CAT
gene id: 9541:CAT
uniprot id: A0A2K5X7W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

9541:SIM1
gene id: 9541:SIM1
uniprot id: A0A2K5W6D0
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102143756
gene id: 9541:LOC102143756
uniprot id: Q4R374
names: Function
names: Subcellular Location Annotation
messages: Connects the two COX monomers into the physiological dimeric form.
messages: Mitochondrion intermembrane space

9541:FMR1
gene id: 9541:FMR1
uniprot id: A0A2K5U918
uniprot id: A0A2K5U936
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9541:ACVR1C
gene id: 9541:ACVR1C
uniprot id: A0A2K5VZI1
uniprot id: A0A2K5VZP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:EIF3D
gene id: 9541:EIF3D
uniprot id: A0A2K5X7Q7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9541:CHAT
gene id: 9541:CHAT
uniprot id: A0A2K5VTI9
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9541:METTL3
gene id: 9541:METTL3
uniprot id: A0A8J8XLF4
uniprot id: G7P9P3
names: Similarity
messages: Belongs to the MT-A70-like family.

9541:STX18
gene id: 9541:STX18
uniprot id: A0A2K5VG85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9541:BHMT
gene id: 9541:BHMT
uniprot id: A0A8J8YGY7
uniprot id: G7P7U0
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9541:BACE1
gene id: 9541:BACE1
uniprot id: A0A2K5UWX5
uniprot id: A0A8J8YG33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: Secreted
messages: trans-Golgi network

9541:NEXMIF
gene id: 9541:NEXMIF
uniprot id: A0A2K5TUA9
names: Subcellular Location Annotation
messages: Nucleus

9541:ARL8B
gene id: 9541:ARL8B
uniprot id: A0A7N9CGD0
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: axon
messages: spindle

9541:SLC41A3
gene id: 9541:SLC41A3
uniprot id: A0A2K5WAS0
uniprot id: A0A8J8XXE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9541:B3GALT1
gene id: 9541:B3GALT1
uniprot id: A0A8J8Y920
uniprot id: G7PKQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:NPAS4
gene id: 9541:NPAS4
uniprot id: A0A8J8YIW1
uniprot id: G7PP95
names: Subcellular Location Annotation
messages: Nucleus

9541:CCNY
gene id: 9541:CCNY
uniprot id: A0A2K5TS85
uniprot id: A0A7N9CXY4
uniprot id: Q95LK3
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9541:NCOA2
gene id: 9541:NCOA2
uniprot id: A0A2K5UID3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9541:NDUFAF3
gene id: 9541:NDUFAF3
uniprot id: A0A8J8Y929
uniprot id: G7NXV0
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9541:IDH1
gene id: 9541:IDH1
uniprot id: A0A2K5WJA5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Homodimer.

9541:RNF185
gene id: 9541:RNF185
uniprot id: A0A8J8XQP9
uniprot id: G7PF83
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9541:KIF22
gene id: 9541:KIF22
uniprot id: A0A7N9CVD8
uniprot id: Q4R838
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:ITGAV
gene id: 9541:ITGAV
uniprot id: A0A2K5WCD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9541:AP4B1
gene id: 9541:AP4B1
uniprot id: A0A7N9DG61
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9541:AP2B1
gene id: 9541:AP2B1
uniprot id: A0A2K5V588
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9541:NAA40
gene id: 9541:NAA40
uniprot id: A0A7N9CM48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

9541:OPHN1
gene id: 9541:OPHN1
uniprot id: A0A2K5WWB2
uniprot id: A0A7N9IB65
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynapse
messages: Presynapse
messages: dendrite

9541:RPL36AL
gene id: 9541:RPL36AL
uniprot id: G7Q2K4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9541:KCNA2
gene id: 9541:KCNA2
uniprot id: G7NW44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: lamellipodium membrane
messages: paranodal septate junction
messages: synaptosome

9541:ATP4B
gene id: 9541:ATP4B
uniprot id: A0A8J8XPL0
uniprot id: G7PVS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9541:LOC101866007
gene id: 9541:LOC101866007
uniprot id: A0A2K5VDA9
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9541:GAD1
gene id: 9541:GAD1
uniprot id: A0A2K5VV10
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9541:TMEM233
gene id: 9541:TMEM233
uniprot id: A0A7N9D303
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:NAGA
gene id: 9541:NAGA
uniprot id: A0A2K5U017
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9541:C1H1orf74
gene id: 9541:C1H1orf74
uniprot id: A0A2K5UNI5
names: Similarity
messages: Belongs to the UPF0739 family.

9541:POLR1F
gene id: 9541:POLR1F
uniprot id: A0A2K5VT47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9541:PKNOX2
gene id: 9541:PKNOX2
uniprot id: A0A2K5WSL6
uniprot id: A0A8J8XRF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9541:LOC102124067
gene id: 9541:LOC102124067
uniprot id: A0A8J8XNC4
uniprot id: G7PQY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:GALNT6
gene id: 9541:GALNT6
uniprot id: A0A2K5UX37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:UBLCP1
gene id: 9541:UBLCP1
uniprot id: A0A8J8XGL9
uniprot id: G7P6S1
names: Subcellular Location Annotation
messages: Nucleus

9541:TIMM8A
gene id: 9541:TIMM8A
uniprot id: A0A2K5X878
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9541:ST6GALNAC6
gene id: 9541:ST6GALNAC6
uniprot id: G8F557
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:FGF21
gene id: 9541:FGF21
uniprot id: A0A2K5UYN8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:C15H9orf78
gene id: 9541:C15H9orf78
uniprot id: A0A2K5VWM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLS1 family.
messages: Nucleus

9541:LOC102127670
gene id: 9541:LOC102127670
uniprot id: A0A2K5UN17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:KIF20B
gene id: 9541:KIF20B
uniprot id: A0A2K5X3T5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:FAM174C
gene id: 9541:FAM174C
uniprot id: A0A2K5VFT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9541:LOC102127570
gene id: 9541:LOC102127570
uniprot id: A0A2K5WKI9
names: Similarity
messages: Belongs to the intermediate filament family.

9541:EFNA3
gene id: 9541:EFNA3
uniprot id: A0A2K5VZR7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:NKIRAS2
gene id: 9541:NKIRAS2
uniprot id: A0A8J8XI33
uniprot id: G7PUT9
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9541:WASF1
gene id: 9541:WASF1
uniprot id: A0A2K5TYW2
uniprot id: G8F546
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9541:NEMF
gene id: 9541:NEMF
uniprot id: A0A2K5UCQ5
names: Similarity
messages: Belongs to the NEMF family.

9541:ZNF322
gene id: 9541:ZNF322
uniprot id: Q4R7X8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Interacts with POU5F1.
messages: Nucleus
messages: Significantly enhances POU5F1/OCT4-SOX2-KLF4-MYC (OSKM) mediated reprogramming of mouse embryonic fibroblasts into induced pluripotent stem cells, and can also substitute for SOX2 in this process.
messages: Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation.

9541:GTPBP4
gene id: 9541:GTPBP4
uniprot id: Q4R5E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9541:HOXC5
gene id: 9541:HOXC5
uniprot id: A0A7N9CSP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9541:NOP16
gene id: 9541:NOP16
uniprot id: A0A2K5VCR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9541:NQO1
gene id: 9541:NQO1
uniprot id: A0A2K5TZM3
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9541:LOC102144646
gene id: 9541:LOC102144646
uniprot id: A0A8J8XP23
uniprot id: G7PVB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9541:RAP2B
gene id: 9541:RAP2B
uniprot id: A0A2K5UCT0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9541:LOC102123567
gene id: 9541:LOC102123567
uniprot id: A0A2K5V0A2
names: Similarity
messages: Belongs to the LEO1 family.

9541:GPBP1
gene id: 9541:GPBP1
uniprot id: A0A2K5TL91
uniprot id: A0A8J8YGF1
uniprot id: G7P7J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9541:ART1
gene id: 9541:ART1
uniprot id: A0A2K5WCR3
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9541:TGIF1
gene id: 9541:TGIF1
uniprot id: A0A2K5W8Q8
names: Subcellular Location Annotation
messages: Nucleus

9541:KIF2C
gene id: 9541:KIF2C
uniprot id: A0A2K5VIH2
uniprot id: Q95LP1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
messages: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment.
messages: Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.
messages: Nucleus
messages: Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
messages: The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
messages: Ubiquitinated.
messages: centromere
messages: cytoskeleton
messages: kinetochore

9541:SLC6A4
gene id: 9541:SLC6A4
uniprot id: A7KAX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Synapse
messages: focal adhesion
messages: neuron projection

9541:TRPV6
gene id: 9541:TRPV6
uniprot id: A0A2K5WXF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:ARF5
gene id: 9541:ARF5
uniprot id: I7G7I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9541:NDRG2
gene id: 9541:NDRG2
uniprot id: A0A2K5V3C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

9541:SET
gene id: 9541:SET
uniprot id: A0A2K5U0M4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9541:LDB1
gene id: 9541:LDB1
uniprot id: A0A2K5WUY6
names: Similarity
messages: Belongs to the LDB family.

9541:SUSD6
gene id: 9541:SUSD6
uniprot id: A0A8J8YKY7
uniprot id: G7PAR2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TMEM198
gene id: 9541:TMEM198
uniprot id: I7GF23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9541:DPPA5
gene id: 9541:DPPA5
uniprot id: A0A8J8YQ00
uniprot id: G7P3F8
names: Similarity
messages: Belongs to the KHDC1 family.

9541:CDH7
gene id: 9541:CDH7
uniprot id: A0A8J8YM50
uniprot id: G7PW74
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:LOC102124877
gene id: 9541:LOC102124877
uniprot id: A0A8J8XYA7
uniprot id: G7P9K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:MATN2
gene id: 9541:MATN2
uniprot id: A0A2K5W0B0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:AKT2
gene id: 9541:AKT2
uniprot id: A0A2K5WA57
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9541:SLC6A20
gene id: 9541:SLC6A20
uniprot id: A0A7N9D6L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9541:LOC102124177
gene id: 9541:LOC102124177
uniprot id: A0A2K5U6K9
names: Similarity
messages: Belongs to the SSX family.

9541:TRMT112
gene id: 9541:TRMT112
uniprot id: A0A2K5VLA0
names: Similarity
messages: Belongs to the TRM112 family.

9541:GALK2
gene id: 9541:GALK2
uniprot id: A0A2K5X7L4
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9541:BUD31
gene id: 9541:BUD31
uniprot id: A0A8J8XTI5
uniprot id: G7P0A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9541:TRPC5
gene id: 9541:TRPC5
uniprot id: A0A8J8XXH1
uniprot id: G7Q3H5
names: Subcellular Location Annotation
messages: Membrane

9541:CELF1
gene id: 9541:CELF1
uniprot id: G7PQ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9541:THOC2
gene id: 9541:THOC2
uniprot id: A0A2K5W0N2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

9541:WLS
gene id: 9541:WLS
uniprot id: A0A2K5UNV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9541:SLC25A39
gene id: 9541:SLC25A39
uniprot id: A0A2K5TKD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9541:WEE2
gene id: 9541:WEE2
uniprot id: A0A2K5WPE1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

9541:ALDH1B1
gene id: 9541:ALDH1B1
uniprot id: A0A2K5UHE5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:TOMT
gene id: 9541:TOMT
uniprot id: A0A2K5WTM6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9541:PDK2
gene id: 9541:PDK2
uniprot id: A0A8J8Y3L1
uniprot id: Q4R567
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9541:EXOC1
gene id: 9541:EXOC1
uniprot id: A0A2K5WZS8
uniprot id: A0A2K5WZT6
uniprot id: A0A2K5X0E3
uniprot id: A0A7N9CER2
names: Similarity
messages: Belongs to the SEC3 family.

9541:RAB19
gene id: 9541:RAB19
uniprot id: A0A2K5WAF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

9541:LOC102129793
gene id: 9541:LOC102129793
uniprot id: A0A2K5W0U2
uniprot id: A0A2K5W142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted
messages: acrosome

9541:NRM
gene id: 9541:NRM
uniprot id: A0A2K5X7A8
uniprot id: A0A7N9IHG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9541:SLC14A2
gene id: 9541:SLC14A2
uniprot id: A0A2K5V7Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9541:SSBP3
gene id: 9541:SSBP3
uniprot id: A0A7N9CAU5
uniprot id: A0A7N9CM22
names: Subcellular Location Annotation
messages: Nucleus

9541:GOLT1A
gene id: 9541:GOLT1A
uniprot id: A0A2K5V0D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9541:TMED4
gene id: 9541:TMED4
uniprot id: A0A7N9D1Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:SMG7
gene id: 9541:SMG7
uniprot id: A0A2K5UXC6
uniprot id: A0A8J8YR72
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

9541:COG7
gene id: 9541:COG7
uniprot id: A0A8J8XHI7
uniprot id: G7Q0Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:USP48
gene id: 9541:USP48
uniprot id: A0A2K5X372
uniprot id: A0A2K5X3E9
uniprot id: A0A2K5X3Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

9541:PKIB
gene id: 9541:PKIB
uniprot id: I7GE53
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9541:TNMD
gene id: 9541:TNMD
uniprot id: A0A8J8YP78
uniprot id: G7Q376
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9541:GPR65
gene id: 9541:GPR65
uniprot id: A0A2K5UMR2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:HSPB8
gene id: 9541:HSPB8
uniprot id: A0A2K5UDI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9541:LIMK1
gene id: 9541:LIMK1
uniprot id: G8F3C7
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9541:ERG28
gene id: 9541:ERG28
uniprot id: A0A2K5X8J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:EHF
gene id: 9541:EHF
uniprot id: A0A2K5UMJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:RAD21
gene id: 9541:RAD21
uniprot id: A0A2K5V3E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9541:TXN
gene id: 9541:TXN
uniprot id: A0A7N9CH45
names: Similarity
messages: Belongs to the thioredoxin family.

9541:SLC9A1
gene id: 9541:SLC9A1
uniprot id: A0A2K5WJH0
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9541:TSPAN15
gene id: 9541:TSPAN15
uniprot id: A0A2K5VGL3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:LYZL4
gene id: 9541:LYZL4
uniprot id: A0A8J8XZG4
uniprot id: G7NY74
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

9541:ATAD2B
gene id: 9541:ATAD2B
uniprot id: A0A2K5WQJ1
names: Similarity
messages: Belongs to the AAA ATPase family.

9541:LOC102125111
gene id: 9541:LOC102125111
uniprot id: A0A7N9D5L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:CSTF1
gene id: 9541:CSTF1
uniprot id: A0A8J8YE71
uniprot id: Q4R7X3
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102143668
gene id: 9541:LOC102143668
uniprot id: A0A2K5V7C3
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9541:GPR182
gene id: 9541:GPR182
uniprot id: G7PIU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:COQ5
gene id: 9541:COQ5
uniprot id: A0A2K5WL38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9541:ACTR6
gene id: 9541:ACTR6
uniprot id: G7PJA1
names: Similarity
messages: Belongs to the actin family.

9541:LAMTOR3
gene id: 9541:LAMTOR3
uniprot id: A0A2K5WHQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9541:MOG
gene id: 9541:MOG
uniprot id: Q29ZP0
uniprot id: Q29ZP1
uniprot id: Q29ZP6
uniprot id: Q29ZP7
uniprot id: Q9BGS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion (By similarity).
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9541:NEK7
gene id: 9541:NEK7
uniprot id: A0A8J8YPW1
uniprot id: G7NWH7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:TPST2
gene id: 9541:TPST2
uniprot id: G7PHG0
uniprot id: Q4R863
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane
messages: Homodimer. Can also form heterodimers with TPST1.
messages: N-glycosylated.
messages: Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding cleft.

9541:GLYCTK
gene id: 9541:GLYCTK
uniprot id: A0A2K5V6G9
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9541:EXOC5
gene id: 9541:EXOC5
uniprot id: A0A2K5TMF7
names: Similarity
messages: Belongs to the SEC10 family.

9541:BMP4
gene id: 9541:BMP4
uniprot id: A0A7N9I9M4
names: Similarity
messages: Belongs to the TGF-beta family.

9541:HYI
gene id: 9541:HYI
uniprot id: A0A2K5VFE9
uniprot id: A0A2K5VFF2
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

9541:UGT3A2
gene id: 9541:UGT3A2
uniprot id: A0A7G0UDE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9541:TXLNG
gene id: 9541:TXLNG
uniprot id: G7Q2B0
names: Similarity
messages: Belongs to the taxilin family.

9541:LOC102144405
gene id: 9541:LOC102144405
uniprot id: A0A2K5V8Y3
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9541:LZTFL1
gene id: 9541:LZTFL1
uniprot id: A0A2K5WC78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9541:PAGE1
gene id: 9541:PAGE1
uniprot id: A0A2K5VVI5
names: Similarity
messages: Belongs to the GAGE family.

9541:CD9
gene id: 9541:CD9
uniprot id: A0A2K5WGW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

9541:GABRB1
gene id: 9541:GABRB1
uniprot id: A0A8J8YGX5
uniprot id: G7P5I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:CSRNP2
gene id: 9541:CSRNP2
uniprot id: A0A8J8XPS8
uniprot id: G7PIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9541:LOXL3
gene id: 9541:LOXL3
uniprot id: A0A2K5X388
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9541:LOC107126435
gene id: 9541:LOC107126435
uniprot id: A0A8J8Y118
uniprot id: G7Q164
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9541:LOC102136805
gene id: 9541:LOC102136805
uniprot id: A0A2K5V6C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:NUDT7
gene id: 9541:NUDT7
uniprot id: A0A2K5UA83
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

9541:SLC19A2
gene id: 9541:SLC19A2
uniprot id: A0A2K5WZ82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9541:PAX5
gene id: 9541:PAX5
uniprot id: A0A2K5VLQ1
uniprot id: A0A2K5VM65
names: Subcellular Location Annotation
messages: Nucleus

9541:MOSPD1
gene id: 9541:MOSPD1
uniprot id: A0A2K5X4W1
names: Subcellular Location Annotation
messages: Membrane

9541:MBOAT2
gene id: 9541:MBOAT2
uniprot id: A0A2K5WBM1
names: Subcellular Location Annotation
messages: Membrane

9541:SLC7A4
gene id: 9541:SLC7A4
uniprot id: A0A2K5TND9
names: Subcellular Location Annotation
messages: Membrane

9541:ZNF24
gene id: 9541:ZNF24
uniprot id: A0A2K5URW2
names: Subcellular Location Annotation
messages: Nucleus

9541:CHAC1
gene id: 9541:CHAC1
uniprot id: A0A2K5VHG6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9541:ELP3
gene id: 9541:ELP3
uniprot id: A0A2K5UAP6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9541:PA2G4
gene id: 9541:PA2G4
uniprot id: I7GJ62
names: Similarity
messages: Belongs to the peptidase M24 family.

9541:ASIC2
gene id: 9541:ASIC2
uniprot id: A0A2K5UDU9
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102120517
gene id: 9541:LOC102120517
uniprot id: A0A7N9D9L4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

9541:HMGN2
gene id: 9541:HMGN2
uniprot id: A0A8J8YAJ5
uniprot id: G7NXM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9541:SNAP91
gene id: 9541:SNAP91
uniprot id: A0A2K5VVQ7
uniprot id: A0A2K5VVV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9541:CDC25C
gene id: 9541:CDC25C
uniprot id: A0A2K5V9Q2
uniprot id: Q4R6H0
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9541:KCNK10
gene id: 9541:KCNK10
uniprot id: A0A2K5W234
uniprot id: A0A8J8YKE1
uniprot id: G7PB47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9541:LOC102117828
gene id: 9541:LOC102117828
uniprot id: G7PCH4
uniprot id: Q4R5B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
messages: Mitochondrion inner membrane

9541:G6PD
gene id: 9541:G6PD
uniprot id: A0A7N9CPQ8
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

9541:CRYGB
gene id: 9541:CRYGB
uniprot id: A0A2K5VQC7
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:KPNA4
gene id: 9541:KPNA4
uniprot id: A0A2K5WX73
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9541:HNF4A
gene id: 9541:HNF4A
uniprot id: A0A2K5VA24
uniprot id: A0A2K5VA29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9541:TMEM225
gene id: 9541:TMEM225
uniprot id: A0A8J8XYG3
uniprot id: G7PPD7
names: Subcellular Location Annotation
messages: Membrane

9541:SNRPB
gene id: 9541:SNRPB
uniprot id: A0A2K5WP22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9541:ENO3
gene id: 9541:ENO3
uniprot id: A0A2K5URN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9541:SNX3
gene id: 9541:SNX3
uniprot id: A0A2K5X3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

9541:LGR5
gene id: 9541:LGR5
uniprot id: A0A2K5WIL2
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102138266
gene id: 9541:LOC102138266
uniprot id: A0A2K5VZK6
names: Similarity
messages: Belongs to the PP2C family.

9541:ECI1
gene id: 9541:ECI1
uniprot id: A0A2K5TTJ3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9541:RPS10
gene id: 9541:RPS10
uniprot id: I7G299
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9541:NRN1
gene id: 9541:NRN1
uniprot id: A0A7N9CHF2
names: Similarity
messages: Belongs to the neuritin family.

9541:PACSIN2
gene id: 9541:PACSIN2
uniprot id: A0A2K5WWB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9541:SAG
gene id: 9541:SAG
uniprot id: A0A2K5VU20
names: Similarity
messages: Belongs to the arrestin family.

9541:LOC102123393
gene id: 9541:LOC102123393
uniprot id: Q25MM9
uniprot id: Q4R4I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).
messages: Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG (By similarity). Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2 (but not TERF1) with its C-terminus. Interacts with SLX4/BTBD12. Interacts with TERF2; the interaction is direct (By similarity).
messages: Belongs to the RAP1 family.
messages: Chromosome
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: telomere

9541:STAG3
gene id: 9541:STAG3
uniprot id: A0A2K5TS71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9541:AP2M1
gene id: 9541:AP2M1
uniprot id: A0A7N9CQ19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9541:TLE3
gene id: 9541:TLE3
uniprot id: A0A2K5WD15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9541:RRM1
gene id: 9541:RRM1
uniprot id: A0A8J8YCP7
uniprot id: G7PQZ6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9541:PCOLCE2
gene id: 9541:PCOLCE2
uniprot id: A0A8J8Y7D8
uniprot id: G7P007
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:LOC102118714
gene id: 9541:LOC102118714
uniprot id: A0A2K5UIT1
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9541:TNFAIP1
gene id: 9541:TNFAIP1
uniprot id: A0A8J8YQH9
uniprot id: G7PTW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

9541:CERS3
gene id: 9541:CERS3
uniprot id: A0A2K5VI72
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9541:UTS2
gene id: 9541:UTS2
uniprot id: A0A2K5WRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9541:MYF5
gene id: 9541:MYF5
uniprot id: A0A8J8XGL2
uniprot id: G7PIK2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9541:LOC102143906
gene id: 9541:LOC102143906
uniprot id: A0A2K5WSH4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:ZC3H14
gene id: 9541:ZC3H14
uniprot id: Q4R6F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZC3H14 family.
messages: Interacts with HOOK2. Interacts with ZFC3H1 in a RNase-sensitive manner.
messages: Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
messages: Nucleus speckle

9541:RBM15
gene id: 9541:RBM15
uniprot id: A0A2K5UN70
names: Similarity
messages: Belongs to the RRM Spen family.

9541:MED28
gene id: 9541:MED28
uniprot id: A0A2K5WQA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9541:LIN7A
gene id: 9541:LIN7A
uniprot id: A0A2K5X044
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9541:MST1R
gene id: 9541:MST1R
uniprot id: A0A2K5VT07
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:XPOT
gene id: 9541:XPOT
uniprot id: A0A2K5V425
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9541:LOC107127356
gene id: 9541:LOC107127356
uniprot id: G7PQ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:AQP3
gene id: 9541:AQP3
uniprot id: A0A2K5VFM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9541:USP13
gene id: 9541:USP13
uniprot id: A0A2K5U6N7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:ADGRG7
gene id: 9541:ADGRG7
uniprot id: A0A2K5X8Z4
uniprot id: A0A2K5X9E2
names: Subcellular Location Annotation
messages: Membrane

9541:SETDB1
gene id: 9541:SETDB1
uniprot id: A0A2K5VZX6
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9541:NAV3
gene id: 9541:NAV3
uniprot id: A0A2K5VM19
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9541:SLCO6A1
gene id: 9541:SLCO6A1
uniprot id: A0A2K5WXZ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:FITM2
gene id: 9541:FITM2
uniprot id: A0A2K5VMP8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:SMAD4
gene id: 9541:SMAD4
uniprot id: A0A8J8XZF7
uniprot id: G7PWS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9541:SLC17A4
gene id: 9541:SLC17A4
uniprot id: A0A2K5U213
names: Subcellular Location Annotation
messages: Membrane

9541:ASRGL1
gene id: 9541:ASRGL1
uniprot id: G7PPU6
uniprot id: Q4R7U8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.
messages: Cytoplasm
messages: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9541:MRTO4
gene id: 9541:MRTO4
uniprot id: A0A2K5V748
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9541:TAF9
gene id: 9541:TAF9
uniprot id: A0A2K5VD20
uniprot id: A0A8J8Y5T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9541:POP5
gene id: 9541:POP5
uniprot id: A0A2K5WQZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9541:HSPD1
gene id: 9541:HSPD1
uniprot id: I7G496
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9541:ACP2
gene id: 9541:ACP2
uniprot id: Q4R5N9
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family.
messages: Lysosome lumen
messages: Lysosome membrane
messages: The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen (By similarity).

9541:POLR2B
gene id: 9541:POLR2B
uniprot id: A0A2K5VZA8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9541:MTMR2
gene id: 9541:MTMR2
uniprot id: A0A7N9IAS5
uniprot id: A0A8J8XPP1
uniprot id: G7PNI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9541:TAFA1
gene id: 9541:TAFA1
uniprot id: I7GMV7
names: Similarity
messages: Belongs to the TAFA family.

9541:LSM14A
gene id: 9541:LSM14A
uniprot id: A0A2K5UDC8
names: Similarity
messages: Belongs to the LSM14 family.

9541:LOC102144707
gene id: 9541:LOC102144707
uniprot id: A0A2K5VS16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9541:CDCA7
gene id: 9541:CDCA7
uniprot id: A0A2K5TND4
uniprot id: A0A2K5TND6
uniprot id: A0A8J8XQ54
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:PPDPF
gene id: 9541:PPDPF
uniprot id: A0A2K5X4I8
names: Similarity
messages: Belongs to the PPDPF family.

9541:STAR
gene id: 9541:STAR
uniprot id: A0A2K5UU11
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9541:HMBS
gene id: 9541:HMBS
uniprot id: G7PP48
names: Similarity
messages: Belongs to the HMBS family.

9541:MED11
gene id: 9541:MED11
uniprot id: A0A2K5VQT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9541:DNAJB12
gene id: 9541:DNAJB12
uniprot id: A0A2K5VFF1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:NONO
gene id: 9541:NONO
uniprot id: A0A2K5WWT3
names: Subcellular Location Annotation
messages: Nucleus speckle

9541:TMEM35B
gene id: 9541:TMEM35B
uniprot id: A0A2K5WKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9541:ELF3
gene id: 9541:ELF3
uniprot id: A0A8J8YH53
uniprot id: G7NWE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:FGGY
gene id: 9541:FGGY
uniprot id: A0A2K5WK13
names: Similarity
messages: Belongs to the FGGY kinase family.

9541:STT3A
gene id: 9541:STT3A
uniprot id: A0A8J8XKB3
uniprot id: G7PPM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9541:HTR2C
gene id: 9541:HTR2C
uniprot id: A0A2K5UBW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PMP22
gene id: 9541:PMP22
uniprot id: A0A2K5VV49
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

9541:SPSB3
gene id: 9541:SPSB3
uniprot id: A0A2K5UYN2
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9541:FOXP1
gene id: 9541:FOXP1
uniprot id: A0A2K5X233
names: Subcellular Location Annotation
messages: Nucleus

9541:ACVR2A
gene id: 9541:ACVR2A
uniprot id: A0A7N9IF81
uniprot id: A0A8J8XY46
uniprot id: G7PKJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9541:PCNX1
gene id: 9541:PCNX1
uniprot id: A0A7N9IBD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9541:NIPAL1
gene id: 9541:NIPAL1
uniprot id: A0A2K5WBH5
uniprot id: A0A8J8XE03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9541:CKM
gene id: 9541:CKM
uniprot id: A0A2K5WCT8
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9541:LOC102139144
gene id: 9541:LOC102139144
uniprot id: G7P2Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:RPS6
gene id: 9541:RPS6
uniprot id: Q4R4K6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
messages: Component of the small ribosomal subunit.
messages: Cytoplasm
messages: Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.
messages: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.
messages: Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.

9541:DCP2
gene id: 9541:DCP2
uniprot id: A0A2K5WXJ7
uniprot id: A0A2K5WXS4
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9541:FAM53C
gene id: 9541:FAM53C
uniprot id: A0A8J8XQE5
uniprot id: G7P8E1
names: Similarity
messages: Belongs to the FAM53 family.

9541:COPS5
gene id: 9541:COPS5
uniprot id: A0A8J8YCP6
uniprot id: G7PBZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9541:RCAN2
gene id: 9541:RCAN2
uniprot id: A0A2K5WDW4
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9541:ADCY8
gene id: 9541:ADCY8
uniprot id: A0A2K5TT43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9541:RPL6
gene id: 9541:RPL6
uniprot id: A0A2K5U0H8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9541:ELL
gene id: 9541:ELL
uniprot id: A0A2K5VPN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9541:RPS15
gene id: 9541:RPS15
uniprot id: A0A2K5UXU9
uniprot id: A0A7N9ICI6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Component of the small ribosomal subunit.

9541:LOC102138871
gene id: 9541:LOC102138871
uniprot id: A0A2K5UJS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9541:CCL18
gene id: 9541:CCL18
uniprot id: A0A2K5TKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:TPRA1
gene id: 9541:TPRA1
uniprot id: A0A8J8XCA6
uniprot id: G7PJ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9541:CLEC12B
gene id: 9541:CLEC12B
uniprot id: A0A2K5TTK1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:ACOT8
gene id: 9541:ACOT8
uniprot id: A0A2K5UY94
uniprot id: A0A2K5UYC4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9541:TLCD3A
gene id: 9541:TLCD3A
uniprot id: A0A2K5TJW7
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102137365
gene id: 9541:LOC102137365
uniprot id: A0A2K5UF51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:SLC1A6
gene id: 9541:SLC1A6
uniprot id: A0A2K5W7Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9541:CACNA1S
gene id: 9541:CACNA1S
uniprot id: A0A8J8XWF9
uniprot id: G7NWG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9541:FAM221A
gene id: 9541:FAM221A
uniprot id: A0A2K5WRE7
names: Similarity
messages: Belongs to the FAM221 family.

9541:CPLX1
gene id: 9541:CPLX1
uniprot id: Q4R4N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complexin/synaphin family.
messages: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
messages: Perikaryon
messages: Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).
messages: Presynapse
messages: cytosol

9541:ERG
gene id: 9541:ERG
uniprot id: A0A2K5UZM9
uniprot id: A0A2K5UZU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:PLD3
gene id: 9541:PLD3
uniprot id: A0A8J8XQT5
uniprot id: G7PXL5
names: Similarity
messages: Belongs to the phospholipase D family.

9541:IGF1
gene id: 9541:IGF1
uniprot id: A0A2K5URR6
uniprot id: A0A2K5URS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9541:LANCL2
gene id: 9541:LANCL2
uniprot id: A0A7N9D691
names: Similarity
messages: Belongs to the LanC-like protein family.

9541:NAA10
gene id: 9541:NAA10
uniprot id: A0A2K5VKW9
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9541:XPO4
gene id: 9541:XPO4
uniprot id: A0A2K5UQZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

9541:DAO
gene id: 9541:DAO
uniprot id: A0A2K5UAL0
uniprot id: A0A7N9I9P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9541:PHTF1
gene id: 9541:PHTF1
uniprot id: A0A2K5UPZ5
names: Subcellular Location Annotation
messages: Membrane

9541:TMEM9B
gene id: 9541:TMEM9B
uniprot id: A0A7N9CG06
uniprot id: A0A7N9D7R0
names: Similarity
messages: Belongs to the TMEM9 family.

9541:MED24
gene id: 9541:MED24
uniprot id: A0A2K5W2X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9541:CENPS
gene id: 9541:CENPS
uniprot id: A0A7N9D2J9
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

9541:TMEM88
gene id: 9541:TMEM88
uniprot id: A0A8J8Y4M8
uniprot id: G7PTJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9541:LOC102132836
gene id: 9541:LOC102132836
uniprot id: A0A7N9CSE3
names: Similarity
messages: Belongs to the pro/parathymosin family.

9541:RPS19
gene id: 9541:RPS19
uniprot id: Q25PV7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

9541:TSC22D3
gene id: 9541:TSC22D3
uniprot id: A0A2K5U6V2
uniprot id: A0A8J8Y7S0
uniprot id: G7Q3E9
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9541:TRIM38
gene id: 9541:TRIM38
uniprot id: A0A8J8XDM0
uniprot id: G7P2K9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:FIGN
gene id: 9541:FIGN
uniprot id: A0A2K5WYQ8
uniprot id: A0A8J8XP02
names: Similarity
messages: Belongs to the AAA ATPase family.

9541:ERO1A
gene id: 9541:ERO1A
uniprot id: A0A2K5UA33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9541:LOC107126403
gene id: 9541:LOC107126403
uniprot id: A0A2K5X0X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9541:GTF2H5
gene id: 9541:GTF2H5
uniprot id: A0A8J8XJD9
uniprot id: G7P4W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9541:SYNPR
gene id: 9541:SYNPR
uniprot id: A0A2K5X4L0
uniprot id: A0A2K5X4L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9541:LOC101925870
gene id: 9541:LOC101925870
uniprot id: A0A2K5W5W4
uniprot id: A0A8J8YP37
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9541:ERBIN
gene id: 9541:ERBIN
uniprot id: A0A2K5V407
uniprot id: A0A2K5V423
uniprot id: A0A2K5V490
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9541:TGFB3
gene id: 9541:TGFB3
uniprot id: A0A8J8YEN9
uniprot id: G7PB17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9541:GALR2
gene id: 9541:GALR2
uniprot id: A0A2K5WWW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9541:LOC101925320
gene id: 9541:LOC101925320
uniprot id: Q4R8D3
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9541:FLI1
gene id: 9541:FLI1
uniprot id: A0A2K5X1A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9541:STX19
gene id: 9541:STX19
uniprot id: A0A2K5UDG1
names: Similarity
messages: Belongs to the syntaxin family.

9541:CLDN9
gene id: 9541:CLDN9
uniprot id: A0A2K5UCC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:EYA1
gene id: 9541:EYA1
uniprot id: A0A8J8Y0Y3
uniprot id: G7PC08
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9541:SGCE
gene id: 9541:SGCE
uniprot id: I7G8Y1
uniprot id: Q4R5B1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Golgi apparatus
messages: N-glycosylated.
messages: Ubiquitinated, leading to its degradation by the proteasome.
messages: cytoskeleton
messages: dendrite
messages: sarcolemma

9541:AQP10
gene id: 9541:AQP10
uniprot id: A0A2K5UBW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9541:MRPS5
gene id: 9541:MRPS5
uniprot id: A0A2K5VG54
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9541:HSD17B13
gene id: 9541:HSD17B13
uniprot id: A0A8J8YIB5
uniprot id: G7P5V3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:ELMO3
gene id: 9541:ELMO3
uniprot id: A0A2K5WQB0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9541:TGFBI
gene id: 9541:TGFBI
uniprot id: A0A7N9CID1
names: Subcellular Location Annotation
messages: extracellular matrix

9541:HAUS3
gene id: 9541:HAUS3
uniprot id: A0A2K5U6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9541:ALKBH6
gene id: 9541:ALKBH6
uniprot id: A0A2K5W013
names: Similarity
messages: Belongs to the alkB family.

9541:MYOZ1
gene id: 9541:MYOZ1
uniprot id: A0A2K5WTD3
names: Similarity
messages: Belongs to the myozenin family.

9541:PYGB
gene id: 9541:PYGB
uniprot id: A0A2K5TPE2
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9541:STMN3
gene id: 9541:STMN3
uniprot id: Q4R4N5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the stathmin family.
messages: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.
messages: Golgi apparatus
messages: Interacts with STAT3. Interacts with CLU (secreted form); this interaction may act as an important modulator during neuronal differentiation (By similarity).
messages: N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).
messages: axon
messages: cytosol
messages: growth cone

9541:FAM124B
gene id: 9541:FAM124B
uniprot id: A0A2K5UWB2
names: Similarity
messages: Belongs to the FAM124 family.

9541:LOC102123765
gene id: 9541:LOC102123765
uniprot id: A0A8J8XHR3
uniprot id: G7PWP2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9541:ZDHHC20
gene id: 9541:ZDHHC20
uniprot id: A0A7N9IEJ6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:PSENEN
gene id: 9541:PSENEN
uniprot id: A0A2K5U3R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9541:S100A8
gene id: 9541:S100A8
uniprot id: A0A2K5X560
names: Similarity
messages: Belongs to the S-100 family.

9541:LHFPL6
gene id: 9541:LHFPL6
uniprot id: I7GNY1
names: Subcellular Location Annotation
messages: Membrane

9541:SNX13
gene id: 9541:SNX13
uniprot id: A0A2K5X2F3
names: Similarity
messages: Belongs to the sorting nexin family.

9541:GML
gene id: 9541:GML
uniprot id: A0A2K5TTQ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:MED7
gene id: 9541:MED7
uniprot id: A0A8J8YMB4
uniprot id: G7P6Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9541:TMEM144
gene id: 9541:TMEM144
uniprot id: A0A8J8XHB4
uniprot id: G7P6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9541:SAE1
gene id: 9541:SAE1
uniprot id: I7GJM9
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9541:HLF
gene id: 9541:HLF
uniprot id: A0A2K5V5N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9541:SF3B3
gene id: 9541:SF3B3
uniprot id: A0A8J8XTN4
uniprot id: G7Q1L4
names: Subcellular Location Annotation
messages: Nucleus

9541:UBE2G2
gene id: 9541:UBE2G2
uniprot id: A0A7N9DD68
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:LYG2
gene id: 9541:LYG2
uniprot id: A0A2K5UUM1
uniprot id: G8F441
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9541:STOML1
gene id: 9541:STOML1
uniprot id: A0A2K5WUA5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9541:TFEC
gene id: 9541:TFEC
uniprot id: A0A2K5VA00
uniprot id: A0A7N9CGQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9541:ANO3
gene id: 9541:ANO3
uniprot id: A0A2K5V2S6
uniprot id: A0A2K5V2T9
uniprot id: A0A7N9DAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9541:PCLAF
gene id: 9541:PCLAF
uniprot id: A0A2K5X752
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

9541:LOC102115550
gene id: 9541:LOC102115550
uniprot id: A0A2K5VA77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

9541:NTN4
gene id: 9541:NTN4
uniprot id: A0A2K5TJR4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TBCB
gene id: 9541:TBCB
uniprot id: I7GAX3
names: Similarity
messages: Belongs to the TBCB family.

9541:PAQR7
gene id: 9541:PAQR7
uniprot id: A0A8J8Y7E0
uniprot id: G7NVX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:SLC26A7
gene id: 9541:SLC26A7
uniprot id: A0A2K5U9Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9541:CXCR3
gene id: 9541:CXCR3
uniprot id: A0A2K5UV19
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

9541:ADA
gene id: 9541:ADA
uniprot id: A0A2K5VY31
uniprot id: A0A7N9DHL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasmic vesicle lumen

9541:MRPS7
gene id: 9541:MRPS7
uniprot id: A0A8J8Y331
uniprot id: G7PVD9
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9541:KRT7
gene id: 9541:KRT7
uniprot id: A0A2K5V4I5
names: Similarity
messages: Belongs to the intermediate filament family.

9541:ERP29
gene id: 9541:ERP29
uniprot id: A0A2K5UDP8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: Melanosome

9541:SNX5
gene id: 9541:SNX5
uniprot id: A0A2K5WXX6
uniprot id: A0A7N9C732
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9541:GSK3B
gene id: 9541:GSK3B
uniprot id: A0A2K5U1X8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9541:CDK2AP2
gene id: 9541:CDK2AP2
uniprot id: A0A2K5V6H8
uniprot id: A0A7N9CEQ4
uniprot id: G8F6F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9541:BZW2
gene id: 9541:BZW2
uniprot id: A0A2K5X1J4
uniprot id: G7P0T4
names: Similarity
messages: Belongs to the BZW family.

9541:SULT2A1
gene id: 9541:SULT2A1
uniprot id: P52842
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Homodimer.
messages: Predominanly expressed in liver. Detected also in adrenal gland and in jejunum.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:31100221). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).
messages: cytosol

9541:MOV10
gene id: 9541:MOV10
uniprot id: A0A2K5TYR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9541:RRH
gene id: 9541:RRH
uniprot id: A0A8J8XE25
uniprot id: G7P633
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9541:SLC35A4
gene id: 9541:SLC35A4
uniprot id: G7P8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:RANBP10
gene id: 9541:RANBP10
uniprot id: A0A2K5VBP7
names: Similarity
messages: Belongs to the RANBP9/10 family.

9541:LOC102146388
gene id: 9541:LOC102146388
uniprot id: G7PZ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ANXA4
gene id: 9541:ANXA4
uniprot id: A0A2K5TSU0
uniprot id: A0A8J8XPJ1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

9541:DCAF11
gene id: 9541:DCAF11
uniprot id: A0A2K5UGW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9541:MKS1
gene id: 9541:MKS1
uniprot id: A0A8J8Y989
uniprot id: G7PUF5
names: Subcellular Location Annotation
messages: cilium basal body

9541:SLC1A3
gene id: 9541:SLC1A3
uniprot id: A0A2K5ULK0
uniprot id: A0A8J8Y7D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9541:OLFM3
gene id: 9541:OLFM3
uniprot id: A0A8J8XLY7
uniprot id: G7NV38
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9541:RPS27A
gene id: 9541:RPS27A
uniprot id: Q4R580
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

9541:SKIV2L
gene id: 9541:SKIV2L
uniprot id: A0A2K5WFV6
names: Subcellular Location Annotation
messages: Cytoplasm

9541:CCL1
gene id: 9541:CCL1
uniprot id: A0A8J8Y905
uniprot id: G7PU26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:CUL2
gene id: 9541:CUL2
uniprot id: A0A2K5VN06
names: Similarity
messages: Belongs to the cullin family.

9541:CA5A
gene id: 9541:CA5A
uniprot id: A0A7N9CDB0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9541:CYSLTR2
gene id: 9541:CYSLTR2
uniprot id: A0A7N9CNM6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:TOE1
gene id: 9541:TOE1
uniprot id: A0A2K5VZM3
names: Similarity
messages: Belongs to the CAF1 family.

9541:VAPA
gene id: 9541:VAPA
uniprot id: A0A2K5VVK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:DPH6
gene id: 9541:DPH6
uniprot id: A0A8J8Y4G7
uniprot id: G7PAQ2
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9541:B3GALT2
gene id: 9541:B3GALT2
uniprot id: A0A2K5UPM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:IL21
gene id: 9541:IL21
uniprot id: A0A2K5UL71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9541:TAS2R39
gene id: 9541:TAS2R39
uniprot id: A0A7N9CZT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:RRP12
gene id: 9541:RRP12
uniprot id: A0A2K5WXV4
names: Similarity
messages: Belongs to the RRP12 family.

9541:LOC102127089
gene id: 9541:LOC102127089
uniprot id: G7P2B4
names: Similarity
messages: Belongs to the CFAP144 family.

9541:TMEM258
gene id: 9541:TMEM258
uniprot id: A0A2K5UGV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9541:KDM3A
gene id: 9541:KDM3A
uniprot id: A0A2K5WSI1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9541:EMC2
gene id: 9541:EMC2
uniprot id: G7PCI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

9541:MRPS33
gene id: 9541:MRPS33
uniprot id: A0A8J8YM69
uniprot id: G7P1E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9541:HMGCR
gene id: 9541:HMGCR
uniprot id: A0A2K5U695
uniprot id: A0A7N9CZC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

9541:ABHD2
gene id: 9541:ABHD2
uniprot id: G7P9E4
uniprot id: Q4R2Y9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acylglycerol lipase activity is activated upon binding to progesterone.
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
messages: Cell membrane
messages: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). May also play a role in smooth muscle cells migration (By similarity).

9541:CCDC90B
gene id: 9541:CCDC90B
uniprot id: A0A2K5WFP1
uniprot id: A0A2K5WFQ9
names: Similarity
messages: Belongs to the CCDC90 family.

9541:TRIM45
gene id: 9541:TRIM45
uniprot id: A0A2K5X306
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9541:FOLR1
gene id: 9541:FOLR1
uniprot id: A0A2K5U044
names: Similarity
messages: Belongs to the folate receptor family.

9541:NSUN2
gene id: 9541:NSUN2
uniprot id: A0A2K5VSK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9541:DOK6
gene id: 9541:DOK6
uniprot id: A0A7N9CHL0
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9541:FAM3A
gene id: 9541:FAM3A
uniprot id: A0A2K5VW74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9541:SLC11A2
gene id: 9541:SLC11A2
uniprot id: Q9MZV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9541:WDR48
gene id: 9541:WDR48
uniprot id: A0A2K5VW67
uniprot id: A0A2K5VWB3
uniprot id: G7NYJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Late endosome

9541:VPS54
gene id: 9541:VPS54
uniprot id: A0A2K5W0T5
uniprot id: A0A8J8Y6W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

9541:PFN3
gene id: 9541:PFN3
uniprot id: A0A2K5UGF2
names: Similarity
messages: Belongs to the profilin family.

9541:SLC29A1
gene id: 9541:SLC29A1
uniprot id: A0A2K5WL78
uniprot id: G7P406
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9541:CDK5
gene id: 9541:CDK5
uniprot id: A0A2K5TYL9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:PHGDH
gene id: 9541:PHGDH
uniprot id: A0A158SIP3
uniprot id: Q60HD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
messages: Homotetramer.

9541:TUBGCP4
gene id: 9541:TUBGCP4
uniprot id: A0A2K5TQ93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9541:CLDN8
gene id: 9541:CLDN8
uniprot id: G7P1L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:LOC102130191
gene id: 9541:LOC102130191
uniprot id: A0A2K5W618
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9541:ACAT2
gene id: 9541:ACAT2
uniprot id: A0A2K5V9T2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9541:ZIC3
gene id: 9541:ZIC3
uniprot id: A0A2K5UKM4
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9541:PLD1
gene id: 9541:PLD1
uniprot id: A0A2K5W7U5
names: Similarity
messages: Belongs to the phospholipase D family.

9541:OLFM2
gene id: 9541:OLFM2
uniprot id: A0A2K5U0Y2
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9541:CCL26
gene id: 9541:CCL26
uniprot id: A0A2K5UWH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:CHL1
gene id: 9541:CHL1
uniprot id: A0A2K5U5I6
uniprot id: A0A2K5U5L5
uniprot id: A0A2K5U5M5
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9541:MFAP5
gene id: 9541:MFAP5
uniprot id: A0A7N9ICY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

9541:SMC4
gene id: 9541:SMC4
uniprot id: A0A2K5WAA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Chromosome
messages: Nucleus

9541:SMPX
gene id: 9541:SMPX
uniprot id: A0A8J8YPK5
uniprot id: G7Q2C8
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

9541:LOC102120872
gene id: 9541:LOC102120872
uniprot id: A0A2K5WIV2
names: Similarity
messages: Belongs to the intermediate filament family.

9541:ANXA1
gene id: 9541:ANXA1
uniprot id: A0A2K5W030
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9541:ADD1
gene id: 9541:ADD1
uniprot id: A0A2K5U2Z1
uniprot id: A0A2K5U319
uniprot id: A0A2K5U342
uniprot id: A0A7N9CQE1
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9541:RNASE4
gene id: 9541:RNASE4
uniprot id: G7P9M0
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:SNX33
gene id: 9541:SNX33
uniprot id: A0A2K5TY56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9541:LOC102134759
gene id: 9541:LOC102134759
uniprot id: A0A2K5X2I4
names: Similarity
messages: Belongs to the intermediate filament family.

9541:LOC102122852
gene id: 9541:LOC102122852
uniprot id: A0A8J8YAJ5
uniprot id: G7NXM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9541:TPPP3
gene id: 9541:TPPP3
uniprot id: A0A2K5USV3
names: Similarity
messages: Belongs to the TPPP family.

9541:JAGN1
gene id: 9541:JAGN1
uniprot id: A0A2K5WLU3
uniprot id: G8F652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:WNT16
gene id: 9541:WNT16
uniprot id: A0A2K5UVE2
uniprot id: A0A8J8YBR9
uniprot id: G7P0J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:PANX3
gene id: 9541:PANX3
uniprot id: A0A2K5VA54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9541:MRPL50
gene id: 9541:MRPL50
uniprot id: A0A7N9D744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9541:RARB
gene id: 9541:RARB
uniprot id: A0A2K5WS97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9541:LOC107129593
gene id: 9541:LOC107129593
uniprot id: A0A8U0WQ25
uniprot id: G8F3V0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:CLDN4
gene id: 9541:CLDN4
uniprot id: A0A2K5UJH5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:MTNR1A
gene id: 9541:MTNR1A
uniprot id: C9WTA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9541:AK1
gene id: 9541:AK1
uniprot id: A0A2K5V0D6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

9541:ERH
gene id: 9541:ERH
uniprot id: A0A2K5U2F3
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9541:CD44
gene id: 9541:CD44
uniprot id: A0A2K5VIV5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

9541:NARF
gene id: 9541:NARF
uniprot id: A0A2K5W8L6
uniprot id: A0A2K5W8M3
names: Similarity
messages: Belongs to the NARF family.

9541:UXT
gene id: 9541:UXT
uniprot id: A0A2K5TZQ7
names: Similarity
messages: Belongs to the UXT family.

9541:YWHAB
gene id: 9541:YWHAB
uniprot id: A0A158SIP8
uniprot id: Q4R572
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2. Interacts with YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT. Interacts with MYO1C. Interacts with SIRT2 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B. Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (By similarity). Interacts with SLITRK1. Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form); this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (By similarity). Interacts with MARK2 and MARK3 (By similarity). Interacts with TESK1; the interaction is dependent on the phosphorylation of TESK1 'Ser-437' and inhibits TESK1 kinase activity (By similarity). Interacts with MEFV (By similarity). Interacts with HDAC4 (By similarity). Interacts with ADAM22 (via C-terminus) (By similarity).
messages: Inferred by similarity.
messages: Isoform Short contains a N-acetylmethionine at position 1.
messages: Melanosome
messages: The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.

9541:RAB27A
gene id: 9541:RAB27A
uniprot id: A0A8J8XYX3
uniprot id: G7PBI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9541:OSBPL11
gene id: 9541:OSBPL11
uniprot id: A0A2K5VPP6
names: Similarity
messages: Belongs to the OSBP family.

9541:CRKL
gene id: 9541:CRKL
uniprot id: A0A8J8YEB0
uniprot id: G7PHA6
names: Similarity
messages: Belongs to the CRK family.

9541:UBP1
gene id: 9541:UBP1
uniprot id: A0A2K5U1K2
uniprot id: A0A2K5U1L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9541:LOC102130495
gene id: 9541:LOC102130495
uniprot id: A0A8J8XAW2
uniprot id: G7P5Z7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:SPC25
gene id: 9541:SPC25
uniprot id: A0A8J8YF95
uniprot id: G7PKR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9541:SPNS1
gene id: 9541:SPNS1
uniprot id: G7Q0T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9541:UBE2F
gene id: 9541:UBE2F
uniprot id: A0A2K5VBA5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:DNM1L
gene id: 9541:DNM1L
uniprot id: A0A2K5UCX1
uniprot id: A0A2K5UCX6
uniprot id: A0A2K5UD34
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9541:SLC26A6
gene id: 9541:SLC26A6
uniprot id: A0A2K5WID5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9541:SEMA3D
gene id: 9541:SEMA3D
uniprot id: A0A2K5VQE5
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102143300
gene id: 9541:LOC102143300
uniprot id: A0A2K5VH37
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

9541:BTBD10
gene id: 9541:BTBD10
uniprot id: A0A2K5TQ72
uniprot id: G7PQP3
names: Subcellular Location Annotation
messages: Cytoplasm

9541:SURF4
gene id: 9541:SURF4
uniprot id: A0A7N9CUS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:BTG4
gene id: 9541:BTG4
uniprot id: A0A7N9D0K2
names: Similarity
messages: Belongs to the BTG family.

9541:FBXO32
gene id: 9541:FBXO32
uniprot id: A0A2K5X1L4
names: Subcellular Location Annotation
messages: Nucleus

9541:SERPINB1
gene id: 9541:SERPINB1
uniprot id: A0A2K5TTD0
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9541:FBLN5
gene id: 9541:FBLN5
uniprot id: A0A2K5VLE1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TAF11
gene id: 9541:TAF11
uniprot id: A0A2K5VAH3
names: Similarity
messages: Belongs to the TAF11 family.

9541:SLC25A35
gene id: 9541:SLC25A35
uniprot id: A0A7N9CM21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:FURIN
gene id: 9541:FURIN
uniprot id: A0A2K5U5X5
names: Similarity
messages: Belongs to the peptidase S8 family.

9541:CERCAM
gene id: 9541:CERCAM
uniprot id: A0A2K5TVP7
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9541:TFCP2
gene id: 9541:TFCP2
uniprot id: A0A2K5TXR1
uniprot id: A0A7N9IEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9541:ARMT1
gene id: 9541:ARMT1
uniprot id: A0A2K5VA55
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9541:REEP3
gene id: 9541:REEP3
uniprot id: A0A2K5UQB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9541:FXYD6
gene id: 9541:FXYD6
uniprot id: A0A2K5U219
uniprot id: G7PP24
names: Similarity
messages: Belongs to the FXYD family.

9541:PEX16
gene id: 9541:PEX16
uniprot id: A0A2K5TZ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9541:GPM6A
gene id: 9541:GPM6A
uniprot id: A0A2K5UTC4
uniprot id: A0A8J8XLU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9541:PHAF1
gene id: 9541:PHAF1
uniprot id: A0A8J8YPC1
uniprot id: G7Q1C4
names: Similarity
messages: Belongs to the PHAF1 family.

9541:PIGC
gene id: 9541:PIGC
uniprot id: A0A2K5UID7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9541:CPNE3
gene id: 9541:CPNE3
uniprot id: A0A2K5UVS8
names: Similarity
messages: Belongs to the copine family.

9541:VSNL1
gene id: 9541:VSNL1
uniprot id: Q4R5F7
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the recoverin family.
messages: Probably binds three calcium ions.
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

9541:DARS1
gene id: 9541:DARS1
uniprot id: A0A2K5UEA8
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9541:CPNE5
gene id: 9541:CPNE5
uniprot id: A0A2K5X2P2
names: Similarity
messages: Belongs to the copine family.

9541:TAC3
gene id: 9541:TAC3
uniprot id: A0A7N9CCQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9541:NGFR
gene id: 9541:NGFR
uniprot id: A0A2K5VJS0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:NDST3
gene id: 9541:NDST3
uniprot id: A0A2K5WFH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9541:SLC28A1
gene id: 9541:SLC28A1
uniprot id: A0A2K5TJ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9541:TRMT13
gene id: 9541:TRMT13
uniprot id: A0A8J8Y3H0
uniprot id: G7NV26
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9541:LOC101926276
gene id: 9541:LOC101926276
uniprot id: A0A2K5VBJ9
uniprot id: G8F324
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:ZDHHC9
gene id: 9541:ZDHHC9
uniprot id: A0A8J8XH94
uniprot id: G7Q3N4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:DHX15
gene id: 9541:DHX15
uniprot id: A0A2K5WB33
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9541:AGK
gene id: 9541:AGK
uniprot id: A0A2K5WYW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9541:CAMK2G
gene id: 9541:CAMK2G
uniprot id: I7GJL2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9541:CYP1B1
gene id: 9541:CYP1B1
uniprot id: A0A2K5UT62
uniprot id: A0A7N9D2X8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:KEG98 p01
gene id: 9541:KEG98_p01
uniprot id: C3W4Z7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

9541:TPPP2
gene id: 9541:TPPP2
uniprot id: G7P9N0
uniprot id: Q4R3A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: Probable regulator of microtubule dynamics required for sperm motility (By similarity). In contrast to other members of the family, has no microtubule bundling activity (By similarity).
messages: cytosol
messages: flagellum

9541:MRPS21
gene id: 9541:MRPS21
uniprot id: A0A8J8Y104
uniprot id: G7NTS9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9541:RAPSN
gene id: 9541:RAPSN
uniprot id: A0A2K5WJX9
names: Similarity
messages: Belongs to the RAPsyn family.

9541:BCL7C
gene id: 9541:BCL7C
uniprot id: A0A2K5V193
uniprot id: A0A2K5V1A2
names: Similarity
messages: Belongs to the BCL7 family.

9541:SFRP2
gene id: 9541:SFRP2
uniprot id: A0A2K5WND6
uniprot id: G8F2Z7
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102121157
gene id: 9541:LOC102121157
uniprot id: G7PQ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:NDUFS7
gene id: 9541:NDUFS7
uniprot id: A0A2K5TZV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 20 kDa subunit family.
messages: Mitochondrion inner membrane

9541:LOC102117187
gene id: 9541:LOC102117187
uniprot id: A0A2K5UPR2
uniprot id: G7NTR4
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:SLC25A30
gene id: 9541:SLC25A30
uniprot id: A0A2K5VAR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:LDHB
gene id: 9541:LDHB
uniprot id: G7PCH4
uniprot id: Q4R5B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
messages: Mitochondrion inner membrane

9541:SLC1A4
gene id: 9541:SLC1A4
uniprot id: A0A2K5WCM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9541:PSEN1
gene id: 9541:PSEN1
uniprot id: A0A8J8XDD5
uniprot id: G7PAT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9541:LOC102130617
gene id: 9541:LOC102130617
uniprot id: A0A2K5WX78
uniprot id: A0A8J8XVQ5
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

9541:MAN1B1
gene id: 9541:MAN1B1
uniprot id: A0A2K5W1J4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9541:FOXP2
gene id: 9541:FOXP2
uniprot id: A0A2K5X941
names: Subcellular Location Annotation
messages: Nucleus

9541:GPRC5D
gene id: 9541:GPRC5D
uniprot id: A0A2K5W6I7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:FAXDC2
gene id: 9541:FAXDC2
uniprot id: Q9GKT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Cytoplasm
messages: Membrane
messages: Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression.

9541:TGFBR2
gene id: 9541:TGFBR2
uniprot id: A0A2K5WD61
uniprot id: A0A2K5WD91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

9541:SYNDIG1
gene id: 9541:SYNDIG1
uniprot id: G7PH54
uniprot id: Q4R532
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CD225/Dispanin family.
messages: Cell membrane
messages: Early endosome membrane
messages: Homodimer. Interacts with GRIA1 and GRIA2 (By similarity).
messages: May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.
messages: Postsynaptic density membrane
messages: Synapse
messages: dendrite
messages: dendritic spine

9541:DNAJC24
gene id: 9541:DNAJC24
uniprot id: A0A2K5UDF8
names: Similarity
messages: Belongs to the DPH4 family.

9541:TMEM251
gene id: 9541:TMEM251
uniprot id: A0A2K5VWV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Membrane

9541:GPHB5
gene id: 9541:GPHB5
uniprot id: A0A7N9IDV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9541:SLC44A4
gene id: 9541:SLC44A4
uniprot id: A0A2K5WU73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9541:MMGT1
gene id: 9541:MMGT1
uniprot id: A0A8J8Y4Z9
uniprot id: G7Q1S3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

9541:S100A6
gene id: 9541:S100A6
uniprot id: A0A2K5V4Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
messages: Nucleus envelope

9541:TOM1
gene id: 9541:TOM1
uniprot id: A0A7N9IGN3
uniprot id: G7PFA5
names: Similarity
messages: Belongs to the TOM1 family.

9541:TCEA1
gene id: 9541:TCEA1
uniprot id: A0A2K5VW82
uniprot id: A0A2K5VWA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9541:SLC12A3
gene id: 9541:SLC12A3
uniprot id: A0A8J8XK92
uniprot id: G7Q167
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9541:TDRD3
gene id: 9541:TDRD3
uniprot id: A0A2K5UE00
uniprot id: G8F2W0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:HM13
gene id: 9541:HM13
uniprot id: A0A2K5WN40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9541:HDDC2
gene id: 9541:HDDC2
uniprot id: A0A2K5UAF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

9541:FOXN3
gene id: 9541:FOXN3
uniprot id: A0A7N9CQQ7
uniprot id: A0A7N9D9G0
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
messages: Nucleus

9541:LOC102118330
gene id: 9541:LOC102118330
uniprot id: A0A8J8XQP4
uniprot id: G7P2L5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:KCTD17
gene id: 9541:KCTD17
uniprot id: A0A2K5W7C5
uniprot id: A0A2K5W7E2
uniprot id: A0A2K5W7I0
names: Subcellular Location Annotation
messages: Cell membrane

9541:LOC102136972
gene id: 9541:LOC102136972
uniprot id: A0A2K5WX78
uniprot id: A0A8J8XVQ5
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

9541:C3AR1
gene id: 9541:C3AR1
uniprot id: A0A7N9IBB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9541:MKX
gene id: 9541:MKX
uniprot id: A0A7N9IFI3
names: Subcellular Location Annotation
messages: Nucleus

9541:ANXA7
gene id: 9541:ANXA7
uniprot id: A0A2K5VHK9
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9541:SPTSSA
gene id: 9541:SPTSSA
uniprot id: I7GMV0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:PFDN5
gene id: 9541:PFDN5
uniprot id: G7PHU6
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9541:CPLX3
gene id: 9541:CPLX3
uniprot id: A0A2K5VUC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9541:PPP2R5C
gene id: 9541:PPP2R5C
uniprot id: A0A2K5TZ49
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9541:PPP3CC
gene id: 9541:PPP3CC
uniprot id: A0A2K5UDC3
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9541:EXOC3
gene id: 9541:EXOC3
uniprot id: A0A2K5UMY4
names: Similarity
messages: Belongs to the SEC6 family.

9541:LHX3
gene id: 9541:LHX3
uniprot id: A0A2K5X0E1
uniprot id: A0A2K5X0F0
names: Subcellular Location Annotation
messages: Nucleus

9541:ASB12
gene id: 9541:ASB12
uniprot id: A0A8J8Y3T4
uniprot id: G7Q2W5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:HSF2
gene id: 9541:HSF2
uniprot id: A0A2K5V4N2
uniprot id: A0A2K5V4N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9541:NELL2
gene id: 9541:NELL2
uniprot id: A0A2K5X1B5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:GET1
gene id: 9541:GET1
uniprot id: A0A2K5WT71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:PDCL3
gene id: 9541:PDCL3
uniprot id: A0A2K5TXR2
names: Similarity
messages: Belongs to the phosducin family.

9541:CDH9
gene id: 9541:CDH9
uniprot id: A0A2K5U8N6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:PDCL2
gene id: 9541:PDCL2
uniprot id: A0A2K5U7V0
names: Similarity
messages: Belongs to the phosducin family.

9541:CMC2
gene id: 9541:CMC2
uniprot id: A0A8J8XBQ7
uniprot id: G7PZT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9541:PSMB4
gene id: 9541:PSMB4
uniprot id: A0A2K5V8G9
uniprot id: G8F2D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9541:IMP4
gene id: 9541:IMP4
uniprot id: A0A7N9CN51
names: Subcellular Location Annotation
messages: nucleolus

9541:DNPH1
gene id: 9541:DNPH1
uniprot id: A0A2K5WKE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

9541:MAK16
gene id: 9541:MAK16
uniprot id: A0A2K5UUL8
names: Similarity
messages: Belongs to the MAK16 family.

9541:YPEL5
gene id: 9541:YPEL5
uniprot id: A0A8J8XEH2
uniprot id: I7G2D8
names: Similarity
messages: Belongs to the yippee family.

9541:MGST2
gene id: 9541:MGST2
uniprot id: A0A8J8XAJ7
uniprot id: G7P6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:XCR1
gene id: 9541:XCR1
uniprot id: A0A8J8XJL1
uniprot id: G7NY37
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:NTS
gene id: 9541:NTS
uniprot id: A0A8J8XFV0
uniprot id: G7PIL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9541:TMEM17
gene id: 9541:TMEM17
uniprot id: A0A7N9IHF4
names: Subcellular Location Annotation
messages: Membrane

9541:ARFGEF1
gene id: 9541:ARFGEF1
uniprot id: A0A2K5URX1
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9541:TBX10
gene id: 9541:TBX10
uniprot id: A0A2K5UDB5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:FADS2
gene id: 9541:FADS2
uniprot id: G7PPX1
uniprot id: Q4R749
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity).
messages: Membrane
messages: The protein sequence includes a number of characteristic features of microsomal fatty acid desaturases including the three histidine boxes HXXXH, HXXHH, and QXXHH (these domains may contain the active site and/or be involved in metal ion binding), and the N-terminal cytochrome b5 domain containing the heme-binding motif, HPGG, similar to that of other fatty acid desaturases.

9541:TMSB10
gene id: 9541:TMSB10
uniprot id: A0A2K5VWM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9541:LOC102122713
gene id: 9541:LOC102122713
uniprot id: A0A2K5VJX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9541:SLC66A2
gene id: 9541:SLC66A2
uniprot id: A0A2K5UFX7
names: Subcellular Location Annotation
messages: Membrane

9541:LOC102138382
gene id: 9541:LOC102138382
uniprot id: A0A2K5UNQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:SPTY2D1
gene id: 9541:SPTY2D1
uniprot id: A0A2K5VKW5
names: Similarity
messages: Belongs to the SPT2 family.

9541:ABLIM3
gene id: 9541:ABLIM3
uniprot id: A0A2K5VQ57
names: Subcellular Location Annotation
messages: Cytoplasm

9541:MAT2A
gene id: 9541:MAT2A
uniprot id: Q4R924
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain.

9541:CREB1
gene id: 9541:CREB1
uniprot id: A0A2K5X539
uniprot id: A0A7N9D5Y5
uniprot id: A0A8J8XE04
names: Subcellular Location Annotation
messages: Nucleus

9541:TAFA4
gene id: 9541:TAFA4
uniprot id: A0A7N9D012
uniprot id: Q9N0D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAFA family.
messages: Modulates injury-induced and chemical pain hypersensitivity. Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release.
messages: Secreted

9541:SAR1B
gene id: 9541:SAR1B
uniprot id: A0A2K5W6R3
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9541:RRAGB
gene id: 9541:RRAGB
uniprot id: A0A2K5VWB6
uniprot id: A0A8J8Y3S3
uniprot id: G7Q2V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9541:SUOX
gene id: 9541:SUOX
uniprot id: A0A2K5WYK3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Homodimer.
messages: Mitochondrion intermembrane space

9541:LOC102136892
gene id: 9541:LOC102136892
uniprot id: A0A8J8YF44
uniprot id: G7P6V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:SFN
gene id: 9541:SFN
uniprot id: A0A2K5UH26
names: Similarity
messages: Belongs to the 14-3-3 family.

9541:CCL7
gene id: 9541:CCL7
uniprot id: A0A2K5UYM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:PKM
gene id: 9541:PKM
uniprot id: A0A2K5VNC3
uniprot id: I7GH00
names: Similarity
messages: Belongs to the pyruvate kinase family.

9541:LOC102123184
gene id: 9541:LOC102123184
uniprot id: G7P9M6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:GRAMD1A
gene id: 9541:GRAMD1A
uniprot id: A0A2K5V6W0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:PAQR3
gene id: 9541:PAQR3
uniprot id: A0A2K5X979
uniprot id: A0A2K5X986
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:NDUFB8
gene id: 9541:NDUFB8
uniprot id: A0A2K5TS24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:DDX5
gene id: 9541:DDX5
uniprot id: A0A2K5ULU9
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9541:HIF1A
gene id: 9541:HIF1A
uniprot id: Q4R658
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle

9541:LOC102140409
gene id: 9541:LOC102140409
uniprot id: A0A7N9D912
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:ASF1B
gene id: 9541:ASF1B
uniprot id: A0A2K5VLV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9541:GABRA1
gene id: 9541:GABRA1
uniprot id: G7P6T7
uniprot id: Q4R534
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by benzodiazepines, the neuroanesthetic alphaxalone and pentobarbital (By similarity). Inhibited by the antagonist bicuculline (By similarity).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Glycosylated.
messages: Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity). Interacts with UBQLN1 (By similarity). Interacts with TRAK1 (By similarity). Interacts with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4 (By similarity). Interacts with NLGN2 (By similarity). Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (By similarity).
messages: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (By similarity). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The extracellular domain contributes to synaptic contact formation.

9541:BEX4
gene id: 9541:BEX4
uniprot id: A0A2K5UHM0
names: Similarity
messages: Belongs to the BEX family.

9541:BMP7
gene id: 9541:BMP7
uniprot id: A0A2K5V0V5
names: Similarity
messages: Belongs to the TGF-beta family.

9541:CTNND2
gene id: 9541:CTNND2
uniprot id: A0A2K5VL88
names: Similarity
messages: Belongs to the beta-catenin family.

9541:ECSIT
gene id: 9541:ECSIT
uniprot id: Q4R5Q4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (By similarity). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (By similarity). Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Interacts with NDUFAF1. Interacts with ACAD9. Interacts with TRIM59. Interacts with TMEM70 and TMEM242. Interacts (when ubiquitinated) with NF-kappa-B subunits RELA and NFKB1. Interacts with RIGI, IFIT1 and MAVS; these interactions promote RLR-mediated type I IFN induction. Interacts with SQSTM1; this interaction inhibits TLR4 signaling via functional regulation of the TRAF6-ECSIT complex. Interacts with cereblon/CRBN; this interaction inhibits the ubiquitination of ECSIT (By similarity).
messages: Mitochondrion
messages: Nucleus
messages: Ubiquitinated on Lys-372; leading to translocation in the nucleus together with RELA and NFKB1 and expression of NF-kappa-B-dependent genes.

9541:BANF1
gene id: 9541:BANF1
uniprot id: A0A2K5TPY1
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102143000
gene id: 9541:LOC102143000
uniprot id: A0A8J8Y5C1
uniprot id: G7PMS9
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9541:PELI1
gene id: 9541:PELI1
uniprot id: A0A2K5VC28
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9541:UBL4A
gene id: 9541:UBL4A
uniprot id: A0A7N9CJ55
names: Subcellular Location Annotation
messages: cytosol

9541:OTUB2
gene id: 9541:OTUB2
uniprot id: A0A2K5VJQ2
names: Similarity
messages: Belongs to the peptidase C65 family.

9541:PPEF1
gene id: 9541:PPEF1
uniprot id: A0A8J8Y5I8
uniprot id: Q4R4Y0
names: Similarity
messages: Belongs to the PPP phosphatase family.

9541:LCE3A
gene id: 9541:LCE3A
uniprot id: G8F3F0
names: Similarity
messages: Belongs to the LCE family.

9541:INS
gene id: 9541:INS
uniprot id: P30406
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

9541:GNB4
gene id: 9541:GNB4
uniprot id: A0A2K5WWG1
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9541:CDIPT
gene id: 9541:CDIPT
uniprot id: A0A2K5WDN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9541:SERPINB11
gene id: 9541:SERPINB11
uniprot id: A0A8J8Y381
uniprot id: G7PWX7
names: Similarity
messages: Belongs to the serpin family.

9541:LCMT1
gene id: 9541:LCMT1
uniprot id: A0A7N9CIE3
uniprot id: A0A7N9IAE8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9541:SLCO4C1
gene id: 9541:SLCO4C1
uniprot id: A0A2K5WSL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9541:WNT2B
gene id: 9541:WNT2B
uniprot id: A0A2K5TYW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:TMEM53
gene id: 9541:TMEM53
uniprot id: A0A8J8XIR8
uniprot id: G7NUY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9541:LOC102127018
gene id: 9541:LOC102127018
uniprot id: A0A8J8YF72
uniprot id: G7P653
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9541:TFAP2A
gene id: 9541:TFAP2A
uniprot id: A0A2K5WXI6
uniprot id: A0A2K5WXM2
uniprot id: A0A2K5WY51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9541:SLC25A34
gene id: 9541:SLC25A34
uniprot id: A0A7N9D5N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:MAN2A2
gene id: 9541:MAN2A2
uniprot id: A0A2K5V9X7
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9541:TAGLN2
gene id: 9541:TAGLN2
uniprot id: A0A2K5WZ75
names: Similarity
messages: Belongs to the calponin family.

9541:LPCAT3
gene id: 9541:LPCAT3
uniprot id: A0A8J8Y2P3
uniprot id: G7PJP3
names: Subcellular Location Annotation
messages: Membrane

9541:TMEM230
gene id: 9541:TMEM230
uniprot id: A0A7N9D152
uniprot id: I7GDG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9541:LOC102118946
gene id: 9541:LOC102118946
uniprot id: A0A7N9DA28
uniprot id: Q95K74
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation.
messages: Membrane
messages: O-glycosylation at Thr-140 is essential for recognition by PILRA.

9541:GREM2
gene id: 9541:GREM2
uniprot id: A0A7N9CTP7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9541:TRIM2
gene id: 9541:TRIM2
uniprot id: A0A2K5V5W6
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9541:TPH2
gene id: 9541:TPH2
uniprot id: A0A2K5VAQ7
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9541:ALX4
gene id: 9541:ALX4
uniprot id: A0A2K5TXF7
names: Subcellular Location Annotation
messages: Nucleus

9541:WNT11
gene id: 9541:WNT11
uniprot id: A0A2K5VEE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9541:LOC102122677
gene id: 9541:LOC102122677
uniprot id: A0A7N9D9Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PLA2G1B
gene id: 9541:PLA2G1B
uniprot id: A0A7N9IEX0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9541:NDUFB2
gene id: 9541:NDUFB2
uniprot id: A0A7N9CLV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9541:HEXIM1
gene id: 9541:HEXIM1
uniprot id: A0A8J8YQK1
uniprot id: G7PV17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9541:TMEM184B
gene id: 9541:TMEM184B
uniprot id: A0A7N9D347
uniprot id: A0A8J8YHY8
uniprot id: G7PFF1
names: Subcellular Location Annotation
messages: Membrane

9541:ECH1
gene id: 9541:ECH1
uniprot id: A0A2K5VDI1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9541:CPN1
gene id: 9541:CPN1
uniprot id: A0A2K5UDJ6
names: Similarity
messages: Belongs to the peptidase M14 family.

9541:DLGAP4
gene id: 9541:DLGAP4
uniprot id: A0A2K5V1F4
uniprot id: A0A2K5V1M5
names: Similarity
messages: Belongs to the SAPAP family.

9541:SCPEP1
gene id: 9541:SCPEP1
uniprot id: A0A2K5TR63
uniprot id: A0A8J8XDD6
names: Similarity
messages: Belongs to the peptidase S10 family.

9541:IMMT
gene id: 9541:IMMT
uniprot id: A0A2K5VP54
uniprot id: A0A2K5VPB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9541:MYH3
gene id: 9541:MYH3
uniprot id: A0A2K5UD03
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:BEST1
gene id: 9541:BEST1
uniprot id: Q6UY87
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity).
messages: Phosphorylated by PP2A.
messages: Tetramer or pentamers. May interact with PPP2CB and PPP2R1B (By similarity).

9541:ETFRF1
gene id: 9541:ETFRF1
uniprot id: A0A2K5X1B3
names: Similarity
messages: Belongs to the complex I LYR family.

9541:TAF1D
gene id: 9541:TAF1D
uniprot id: A0A2K5X2F2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9541:CDK2
gene id: 9541:CDK2
uniprot id: A0A2K5VPV1
uniprot id: A0A2K5VPW1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:LOC102125774
gene id: 9541:LOC102125774
uniprot id: G7NUF9
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9541:PARP1
gene id: 9541:PARP1
uniprot id: A0A8J8XL21
uniprot id: G7NTV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

9541:ANAPC13
gene id: 9541:ANAPC13
uniprot id: A0A8J8XQ33
uniprot id: G7NXY2
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9541:LOC102124073
gene id: 9541:LOC102124073
uniprot id: A0A2K5X506
names: Subcellular Location Annotation
messages: extracellular matrix

9541:ATP6V1E2
gene id: 9541:ATP6V1E2
uniprot id: A0A2K5UFX9
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9541:B4GALNT1
gene id: 9541:B4GALNT1
uniprot id: A0A2K5WET1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:EIF2D
gene id: 9541:EIF2D
uniprot id: A0A2K5U4Z6
uniprot id: A0A7N9CWY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

9541:APEX2
gene id: 9541:APEX2
uniprot id: A0A8J8Y0B6
uniprot id: G7Q2U4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9541:BEND6
gene id: 9541:BEND6
uniprot id: A0A2K5UQ79
names: Subcellular Location Annotation
messages: Nucleus

9541:TOB1
gene id: 9541:TOB1
uniprot id: A0A8J8XTF8
uniprot id: G7PUB7
names: Similarity
messages: Belongs to the BTG family.

9541:CLPX
gene id: 9541:CLPX
uniprot id: A0A2K5V120
uniprot id: A0A2K5V141
names: Similarity
messages: Belongs to the ClpX chaperone family.

9541:AVPI1
gene id: 9541:AVPI1
uniprot id: A0A2K5VGI2
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9541:SEC61A1
gene id: 9541:SEC61A1
uniprot id: A0A2K5VHH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:FAM168A
gene id: 9541:FAM168A
uniprot id: A0A2K5U445
uniprot id: A0A8J8XHB5
uniprot id: G7PN71
names: Similarity
messages: Belongs to the FAM168 family.

9541:BEX3
gene id: 9541:BEX3
uniprot id: G7Q3C3
names: Similarity
messages: Belongs to the BEX family.

9541:CNOT6
gene id: 9541:CNOT6
uniprot id: A0A8J8XS73
uniprot id: G7P737
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9541:SLC24A2
gene id: 9541:SLC24A2
uniprot id: A0A2K5UX63
uniprot id: A0A2K5UX84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9541:COG2
gene id: 9541:COG2
uniprot id: A0A2K5U426
uniprot id: A0A7N9CLA2
uniprot id: G8F2E0
names: Similarity
messages: Belongs to the COG2 family.

9541:AURKB
gene id: 9541:AURKB
uniprot id: A0A2K5WL61
uniprot id: G7PTK4
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

9541:MIX23
gene id: 9541:MIX23
uniprot id: A0A2K5ULX4
uniprot id: A0A2K5ULX6
names: Similarity
messages: Belongs to the MIX23 family.

9541:RIMKLA
gene id: 9541:RIMKLA
uniprot id: A0A2K5VKU1
names: Similarity
messages: Belongs to the RimK family.

9541:APOO
gene id: 9541:APOO
uniprot id: A0A2K5X7S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9541:NELL1
gene id: 9541:NELL1
uniprot id: A0A2K5VAV9
uniprot id: A0A2K5VAZ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:RIDA
gene id: 9541:RIDA
uniprot id: A0A8J8YT39
uniprot id: G7PCA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

9541:HSPA2
gene id: 9541:HSPA2
uniprot id: G7PAI9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9541:ELMO2
gene id: 9541:ELMO2
uniprot id: A0A8J8Y2M8
uniprot id: G7PG35
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9541:CCDC124
gene id: 9541:CCDC124
uniprot id: A0A2K5TNQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC124 family.
messages: Midbody

9541:CPLX2
gene id: 9541:CPLX2
uniprot id: A0A2K5WJI6
uniprot id: I7GKG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9541:THBS3
gene id: 9541:THBS3
uniprot id: A0A2K5WN13
uniprot id: A0A2K5WN65
uniprot id: A0A2K5WN70
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ATG9A
gene id: 9541:ATG9A
uniprot id: A0A8J8YEM8
uniprot id: G7PK41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9541:PDZK1IP1
gene id: 9541:PDZK1IP1
uniprot id: A0A2K5TZ39
names: Subcellular Location Annotation
messages: Membrane

9541:PDE6D
gene id: 9541:PDE6D
uniprot id: A0A2K5W427
uniprot id: G7PKA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9541:GRM3
gene id: 9541:GRM3
uniprot id: A0A8J8XYC3
uniprot id: G7P1W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9541:CDH20
gene id: 9541:CDH20
uniprot id: A0A7N9IGY0
uniprot id: G7PWW3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:RPL37
gene id: 9541:RPL37
uniprot id: A0A7N9IBE1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9541:RFTN1
gene id: 9541:RFTN1
uniprot id: A0A2K5VGS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9541:NAA25
gene id: 9541:NAA25
uniprot id: A0A2K5WY54
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

9541:MZT1
gene id: 9541:MZT1
uniprot id: A0A2K5VQF6
uniprot id: A0A979HJT3
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9541:DNASE1L1
gene id: 9541:DNASE1L1
uniprot id: A0A8J8YRE0
uniprot id: G7Q218
names: Similarity
messages: Belongs to the DNase I family.

9541:ARL5B
gene id: 9541:ARL5B
uniprot id: A0A7N9CLT2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9541:LOC102124317
gene id: 9541:LOC102124317
uniprot id: A0A8J8XNH7
uniprot id: G7P2M2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:WDR24
gene id: 9541:WDR24
uniprot id: A0A2K5UV49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR24 family.
messages: Lysosome membrane

9541:VLDLR
gene id: 9541:VLDLR
uniprot id: A0A2K5V335
uniprot id: A0A2K5V352
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:HAL
gene id: 9541:HAL
uniprot id: A0A2K5TSK1
names: Similarity
messages: Belongs to the PAL/histidase family.

9541:ORC5
gene id: 9541:ORC5
uniprot id: A0A2K5U0V5
names: Subcellular Location Annotation
messages: Nucleus

9541:OXSR1
gene id: 9541:OXSR1
uniprot id: A0A2K5U411
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9541:NRP2
gene id: 9541:NRP2
uniprot id: A0A2K5X2N5
uniprot id: A0A2K5X335
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SDF4
gene id: 9541:SDF4
uniprot id: A0A2K5X223
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

9541:LDHC
gene id: 9541:LDHC
uniprot id: A0A2K5WD20
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9541:GMPR
gene id: 9541:GMPR
uniprot id: A0A2K5W3H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9541:TADA3
gene id: 9541:TADA3
uniprot id: A0A8J8XXL9
uniprot id: G7NYU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

9541:KRT12
gene id: 9541:KRT12
uniprot id: A0A8J8XZW2
uniprot id: G7PUQ0
names: Similarity
messages: Belongs to the intermediate filament family.

9541:LOC102135406
gene id: 9541:LOC102135406
uniprot id: A0A2K5VQK1
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

9541:STK38L
gene id: 9541:STK38L
uniprot id: A0A2K5USX8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:FGF4
gene id: 9541:FGF4
uniprot id: A0A7N9D0H1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:SLC5A1
gene id: 9541:SLC5A1
uniprot id: A0A2K5VYS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9541:KRT8
gene id: 9541:KRT8
uniprot id: A0A7N9CB91
names: Similarity
messages: Belongs to the intermediate filament family.

9541:SULT2B1
gene id: 9541:SULT2B1
uniprot id: A0A8J8YDJ6
uniprot id: G7PY24
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:RPAP2
gene id: 9541:RPAP2
uniprot id: A0A2K5UY91
uniprot id: G8F395
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

9541:SIAH1
gene id: 9541:SIAH1
uniprot id: G7Q129
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9541:GSS
gene id: 9541:GSS
uniprot id: A0A8J8XKD1
uniprot id: I7GA31
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9541:AKIRIN2
gene id: 9541:AKIRIN2
uniprot id: A0A2K5UJ23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9541:PGF
gene id: 9541:PGF
uniprot id: A0A2K5VMQ8
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9541:TFAP2D
gene id: 9541:TFAP2D
uniprot id: A0A8J8YE07
uniprot id: G7P4U7
names: Similarity
messages: Belongs to the AP-2 family.

9541:DMAP1
gene id: 9541:DMAP1
uniprot id: G7NUY3
names: Subcellular Location Annotation
messages: Nucleus

9541:PENK
gene id: 9541:PENK
uniprot id: A0A2K5UXG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9541:DGCR6L
gene id: 9541:DGCR6L
uniprot id: A0A2K5W0W4
names: Similarity
messages: Belongs to the gonadal family.

9541:LDLRAD4
gene id: 9541:LDLRAD4
uniprot id: A0A2K5UA62
uniprot id: A0A8J8YC76
uniprot id: G7PWB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PIGV
gene id: 9541:PIGV
uniprot id: A0A2K5WCU5
uniprot id: G8F2H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9541:GPAT4
gene id: 9541:GPAT4
uniprot id: A0A7N9DCX4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9541:LOC102120479
gene id: 9541:LOC102120479
uniprot id: P61252
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins (By similarity).
messages: Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Can form disulfide-bonded heterodimer with CD94 (By similarity). Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (By similarity).
messages: Is not capable of signal transduction by itself, but operates through the adapter protein HCST.
messages: Natural killer cells.

9541:CLGN
gene id: 9541:CLGN
uniprot id: A0A8J8YPA9
uniprot id: G7P6B4
names: Similarity
messages: Belongs to the calreticulin family.

9541:CHRND
gene id: 9541:CHRND
uniprot id: A0A2K5V3B3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:TEX10
gene id: 9541:TEX10
uniprot id: A0A8J8YD58
uniprot id: G7PRU3
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9541:PTH
gene id: 9541:PTH
uniprot id: G7PQP2
uniprot id: Q9XT35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
messages: Secreted

9541:PHTF2
gene id: 9541:PHTF2
uniprot id: A0A2K5V766
uniprot id: A0A2K5V778
names: Subcellular Location Annotation
messages: Membrane

9541:RER1
gene id: 9541:RER1
uniprot id: A0A2K5V184
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9541:NAB2
gene id: 9541:NAB2
uniprot id: A0A2K5X146
uniprot id: A0A7N9CY18
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9541:SEMA4C
gene id: 9541:SEMA4C
uniprot id: A0A2K5VV83
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:POLR3GL
gene id: 9541:POLR3GL
uniprot id: A0A8J8YID9
uniprot id: G7NTQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9541:LOC102131775
gene id: 9541:LOC102131775
uniprot id: A0A2K5WHK5
names: Similarity
messages: Belongs to the TCP11 family.

9541:LOC102132001
gene id: 9541:LOC102132001
uniprot id: G7P2N0
uniprot id: Q4R362
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9541:GDA
gene id: 9541:GDA
uniprot id: A0A2K5V8Q6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9541:GNAI3
gene id: 9541:GNAI3
uniprot id: A0A2K5WIQ6
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9541:HINT2
gene id: 9541:HINT2
uniprot id: A0A2K5TRF4
names: Similarity
messages: Belongs to the HINT family.

9541:BMP2
gene id: 9541:BMP2
uniprot id: A0A8J8YC70
uniprot id: G7PGY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9541:TATDN3
gene id: 9541:TATDN3
uniprot id: A0A2K5TT38
uniprot id: A0A2K5TT59
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9541:BAX
gene id: 9541:BAX
uniprot id: A0A2K5V7Y8
names: Similarity
messages: Belongs to the Bcl-2 family.

9541:F2R
gene id: 9541:F2R
uniprot id: A0A2K5VPA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:NECTIN4
gene id: 9541:NECTIN4
uniprot id: A0A2K5WEQ6
uniprot id: A0A2K5WES1
uniprot id: L0N6D9
names: Similarity
messages: Belongs to the nectin family.

9541:ADRA1A
gene id: 9541:ADRA1A
uniprot id: A0A2K5US01
uniprot id: G7PCY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9541:SSR1
gene id: 9541:SSR1
uniprot id: Q4R4P7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9541:CLCN3
gene id: 9541:CLCN3
uniprot id: A0A2K5WZ25
uniprot id: A0A2K5WZE6
uniprot id: A0A2K5WZE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9541:LOC102131151
gene id: 9541:LOC102131151
uniprot id: A0A2K5UAI4
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9541:SLC35F2
gene id: 9541:SLC35F2
uniprot id: A0A2K5VVI2
uniprot id: A0A7N9CJ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9541:NCALD
gene id: 9541:NCALD
uniprot id: Q4R4N4
names: Function
names: Similarity
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).

9541:DNAAF6
gene id: 9541:DNAAF6
uniprot id: A0A8J8XJR1
uniprot id: G7Q3E5
names: Similarity
messages: Belongs to the PIH1 family.

9541:TIMM17B
gene id: 9541:TIMM17B
uniprot id: A0A2K5UAM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9541:CAST
gene id: 9541:CAST
uniprot id: A0A2K5V7W1
uniprot id: A0A2K5V839
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9541:ARSB
gene id: 9541:ARSB
uniprot id: A0A2K5WDQ3
names: Similarity
messages: Belongs to the sulfatase family.

9541:BRMS1L
gene id: 9541:BRMS1L
uniprot id: A0A2K5WK40
names: Subcellular Location Annotation
messages: Nucleus

9541:DCTPP1
gene id: 9541:DCTPP1
uniprot id: A0A8J8YLF7
uniprot id: G7Q0X6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9541:SLC6A7
gene id: 9541:SLC6A7
uniprot id: A0A2K5WY93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9541:CDH2
gene id: 9541:CDH2
uniprot id: A0A2K5UCE0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:FOXI1
gene id: 9541:FOXI1
uniprot id: A0A2K5UFG3
names: Subcellular Location Annotation
messages: Nucleus

9541:TAS2R7
gene id: 9541:TAS2R7
uniprot id: G7PJU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:DKK4
gene id: 9541:DKK4
uniprot id: A0A2K5TRM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9541:FAM241B
gene id: 9541:FAM241B
uniprot id: A0A2K5V1N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9541:PFDN1
gene id: 9541:PFDN1
uniprot id: A0A2K5VMI8
uniprot id: A0A7N9CDD8
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9541:RNF157
gene id: 9541:RNF157
uniprot id: A0A2K5UAD3
uniprot id: A0A7N9IA45
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9541:GPHA2
gene id: 9541:GPHA2
uniprot id: A0A2K5WDU0
names: Caution
names: Similarity
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PADI1
gene id: 9541:PADI1
uniprot id: A0A8J8YFJ7
uniprot id: G7NUR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9541:SLC7A11
gene id: 9541:SLC7A11
uniprot id: A0A8J8XHH6
uniprot id: G7P6A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9541:UBE2D2
gene id: 9541:UBE2D2
uniprot id: A0A2K5WBG0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9541:INTS10
gene id: 9541:INTS10
uniprot id: A0A2K5X2N7
uniprot id: A0A2K5X373
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9541:STAM
gene id: 9541:STAM
uniprot id: A0A2K5VRQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9541:CCDC126
gene id: 9541:CCDC126
uniprot id: A0A8J8XLQ2
uniprot id: G7P0Q6
uniprot id: I7GKP5
names: Subcellular Location Annotation
messages: Secreted

9541:EDEM2
gene id: 9541:EDEM2
uniprot id: A0A2K5WEL9
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9541:DSG3
gene id: 9541:DSG3
uniprot id: A0A2K5UXA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9541:ACSS3
gene id: 9541:ACSS3
uniprot id: A0A2K5U1S4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:ALKBH7
gene id: 9541:ALKBH7
uniprot id: A0A2K5WQX0
names: Similarity
messages: Belongs to the alkB family.

9541:TAF8
gene id: 9541:TAF8
uniprot id: A0A2K5U5F7
uniprot id: A0A7N9DFF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9541:SEMA3F
gene id: 9541:SEMA3F
uniprot id: A0A2K5TXU6
uniprot id: A0A2K5TXU8
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:APOL2
gene id: 9541:APOL2
uniprot id: A0A7N9CF82
names: Similarity
messages: Belongs to the apolipoprotein L family.

9541:DCTN5
gene id: 9541:DCTN5
uniprot id: A0A2K5VT33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

9541:NSA2
gene id: 9541:NSA2
uniprot id: A0A2K5TRY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9541:MMS19
gene id: 9541:MMS19
uniprot id: A0A2K5VPX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9541:TMOD2
gene id: 9541:TMOD2
uniprot id: A0A2K5VSA0
names: Subcellular Location Annotation
messages: cytoskeleton

9541:HOXC6
gene id: 9541:HOXC6
uniprot id: A0A8J8XH79
uniprot id: G7PHW2
names: Subcellular Location Annotation
messages: Nucleus

9541:TMEM63C
gene id: 9541:TMEM63C
uniprot id: A0A2K5WA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9541:B4GALT4
gene id: 9541:B4GALT4
uniprot id: A0A2K5WCS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9541:ING5
gene id: 9541:ING5
uniprot id: A0A2K5V8Z5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9541:DMC1
gene id: 9541:DMC1
uniprot id: A0A2K5VU11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

9541:SMC5
gene id: 9541:SMC5
uniprot id: G7PSI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9541:MTFR1
gene id: 9541:MTFR1
uniprot id: G7PBX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9541:CDC42SE2
gene id: 9541:CDC42SE2
uniprot id: A0A2K5W700
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9541:C14H11orf49
gene id: 9541:C14H11orf49
uniprot id: A0A2K5WLS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: cytoskeleton

9541:GRM2
gene id: 9541:GRM2
uniprot id: A0A2K5WQG4
uniprot id: A0A8J8Y634
uniprot id: G7NZX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9541:HSF4
gene id: 9541:HSF4
uniprot id: A0A2K5V1D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9541:GINS4
gene id: 9541:GINS4
uniprot id: A0A8J8XEM9
uniprot id: G7PD92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9541:ELAVL3
gene id: 9541:ELAVL3
uniprot id: A0A2K5WBH7
names: Similarity
messages: Belongs to the RRM elav family.

9541:DDX58
gene id: 9541:DDX58
uniprot id: G7PS60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9541:CRX
gene id: 9541:CRX
uniprot id: A0A2K5X2T7
names: Subcellular Location Annotation
messages: Nucleus

9541:SERINC4
gene id: 9541:SERINC4
uniprot id: A0A2K5U2N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9541:GREM1
gene id: 9541:GREM1
uniprot id: A0A7N9DCE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9541:LIPN
gene id: 9541:LIPN
uniprot id: A0A8J8Y3P4
uniprot id: G7PDH4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9541:LOC102123517
gene id: 9541:LOC102123517
uniprot id: A0A2K5W3F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:GUK1
gene id: 9541:GUK1
uniprot id: A0A2K5WYD7
names: Similarity
messages: Belongs to the guanylate kinase family.

9541:LOC101865054
gene id: 9541:LOC101865054
uniprot id: A0A2K5VPJ1
names: Similarity
messages: Belongs to the PHYHIP family.

9541:NTRK3
gene id: 9541:NTRK3
uniprot id: A0A2K5VL93
uniprot id: A0A2K5VLB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9541:DHX9
gene id: 9541:DHX9
uniprot id: A0A2K5WUX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9541:LOC102138308
gene id: 9541:LOC102138308
uniprot id: A0A2K5UID5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:LOC102122149
gene id: 9541:LOC102122149
uniprot id: A0A8J8Y9Z4
uniprot id: G7P524
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9541:TMEM200A
gene id: 9541:TMEM200A
uniprot id: A0A8J8Y2X5
uniprot id: G7P364
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9541:CHRNB4
gene id: 9541:CHRNB4
uniprot id: A0A2K5VK87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:SGCZ
gene id: 9541:SGCZ
uniprot id: A0A2K5WQ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9541:CYP1A1
gene id: 9541:CYP1A1
uniprot id: A0A8J8YNV8
uniprot id: G7P943
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9541:TRIM50
gene id: 9541:TRIM50
uniprot id: A0A2K5UQX6
uniprot id: A0A8J8Y414
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9541:DOLPP1
gene id: 9541:DOLPP1
uniprot id: A0A2K5WQ40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9541:OLFML1
gene id: 9541:OLFML1
uniprot id: A0A8J8XZH5
uniprot id: G7PQT9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:EPHA3
gene id: 9541:EPHA3
uniprot id: A0A2K5UU29
names: Subcellular Location Annotation
messages: Membrane

9541:PPP1R15B
gene id: 9541:PPP1R15B
uniprot id: A0A8J8XZ24
uniprot id: G7NVE1
names: Similarity
messages: Belongs to the PPP1R15 family.

9541:RPS28
gene id: 9541:RPS28
uniprot id: A0A2K5W098
uniprot id: G8F4P1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

9541:PALS1
gene id: 9541:PALS1
uniprot id: A0A2K5UDI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: adherens junction
messages: tight junction

9541:PDE1B
gene id: 9541:PDE1B
uniprot id: G7PHX1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:RPS5
gene id: 9541:RPS5
uniprot id: A0A2K5WE29
uniprot id: A0A8J8XCP0
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9541:TMEM106C
gene id: 9541:TMEM106C
uniprot id: A0A8J8XK76
uniprot id: G7PHP8
names: Similarity
messages: Belongs to the TMEM106 family.

9541:ROM1
gene id: 9541:ROM1
uniprot id: A0A8J8Y7A2
uniprot id: G7PPU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9541:CKS1B
gene id: 9541:CKS1B
uniprot id: A0A7N9DBP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9541:ARMC1
gene id: 9541:ARMC1
uniprot id: A0A8J8XP95
uniprot id: G7PBX8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9541:BICD1
gene id: 9541:BICD1
uniprot id: A0A2K5TK20
uniprot id: A0A7N9CYZ3
names: Similarity
messages: Belongs to the BicD family.

9541:ASB8
gene id: 9541:ASB8
uniprot id: A0A8J8XBK7
uniprot id: G7PHQ2
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9541:LIG4
gene id: 9541:LIG4
uniprot id: A0A7N9CEX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9541:LOC102121007
gene id: 9541:LOC102121007
uniprot id: A0A2K5V5R5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:AZIN1
gene id: 9541:AZIN1
uniprot id: A0A2K5WZB4
uniprot id: I7GIW1
uniprot id: I7GJ97
uniprot id: I7GMJ8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9541:TRNT1
gene id: 9541:TRNT1
uniprot id: A0A2K5VRQ5
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9541:TMEM86A
gene id: 9541:TMEM86A
uniprot id: A0A7N9CDZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9541:LOC102124735
gene id: 9541:LOC102124735
uniprot id: A0A2K5UVV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:CLDND1
gene id: 9541:CLDND1
uniprot id: Q4R4Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9541:OSTC
gene id: 9541:OSTC
uniprot id: A0A2K5WH47
uniprot id: A0A2K5WHC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9541:SESN2
gene id: 9541:SESN2
uniprot id: A0A2K5VDA2
uniprot id: A0A7N9D8A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9541:DESI1
gene id: 9541:DESI1
uniprot id: A0A7N9D5H3
names: Similarity
messages: Belongs to the DeSI family.

9541:CSNK1A1L
gene id: 9541:CSNK1A1L
uniprot id: A0A2K5VAN7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:SPOCK3
gene id: 9541:SPOCK3
uniprot id: A0A2K5X528
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:CD36
gene id: 9541:CD36
uniprot id: A0A8J8XGH3
uniprot id: Q4R6B4
names: Similarity
messages: Belongs to the CD36 family.

9541:ID2
gene id: 9541:ID2
uniprot id: A0A805PDB8
names: Subcellular Location Annotation
messages: Nucleus

9541:FIBIN
gene id: 9541:FIBIN
uniprot id: A0A7N9CYV4
uniprot id: G8F334
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9541:SERPINB10
gene id: 9541:SERPINB10
uniprot id: A0A2K5V9V3
names: Similarity
messages: Belongs to the serpin family.

9541:HIGD2A
gene id: 9541:HIGD2A
uniprot id: A0A8J8Y250
uniprot id: G7P6Y9
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9541:ROMO1
gene id: 9541:ROMO1
uniprot id: A0A2K5WQW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9541:SCRN2
gene id: 9541:SCRN2
uniprot id: A0A2K5U580
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9541:MFSD14A
gene id: 9541:MFSD14A
uniprot id: A0A2K5WYA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9541:ICMT
gene id: 9541:ICMT
uniprot id: A0A2K5UYR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:ZNF496
gene id: 9541:ZNF496
uniprot id: A0A2K5U2R3
names: Subcellular Location Annotation
messages: Nucleus

9541:SERPINC1
gene id: 9541:SERPINC1
uniprot id: A0A2K5UYN7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9541:RPL17
gene id: 9541:RPL17
uniprot id: A0A2K5TPE4
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9541:SIAH3
gene id: 9541:SIAH3
uniprot id: A0A8J8XZY6
uniprot id: G7PW59
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9541:CACNB1
gene id: 9541:CACNB1
uniprot id: A0A2K5TYA2
uniprot id: A0A2K5TYD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Membrane
messages: sarcolemma

9541:CLVS2
gene id: 9541:CLVS2
uniprot id: Q95KF7
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Binding to PtdIns(3,5)P2 is not required for localization.
messages: Early endosome membrane
messages: Forms a complex with clathrin heavy chain and gamma-adaptin.
messages: Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).
messages: The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9541:PLCB4
gene id: 9541:PLCB4
uniprot id: A0A2K5TNY0
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9541:CREB5
gene id: 9541:CREB5
uniprot id: A0A2K5TR28
uniprot id: A0A2K5TR43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

9541:CD68
gene id: 9541:CD68
uniprot id: A0A8J8XNB1
uniprot id: G7PTI2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9541:SNX17
gene id: 9541:SNX17
uniprot id: A0A2K5X0R5
uniprot id: A0A8J8YBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9541:RAB3D
gene id: 9541:RAB3D
uniprot id: A0A2K5TXE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9541:CYP4V2
gene id: 9541:CYP4V2
uniprot id: A0A2K5U594
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:RBCK1
gene id: 9541:RBCK1
uniprot id: A0A2K5VYQ0
names: Similarity
messages: Belongs to the RBR family.

9541:CCDC103
gene id: 9541:CCDC103
uniprot id: A0A2K5TU89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9541:DEFB125
gene id: 9541:DEFB125
uniprot id: A4H241
uniprot id: G7PGQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:TRIM27
gene id: 9541:TRIM27
uniprot id: A0A7N9D5W7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:LOC102131393
gene id: 9541:LOC102131393
uniprot id: A0A2K5X0G8
names: Similarity
messages: Belongs to the IAP family.

9541:C10H20orf27
gene id: 9541:C10H20orf27
uniprot id: A0A2K5UJP1
names: Similarity
messages: Belongs to the ADISSP family.

9541:GABRR1
gene id: 9541:GABRR1
uniprot id: A0A2K5TTB5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:TBCCD1
gene id: 9541:TBCCD1
uniprot id: A0A2K5WF23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9541:ZZZ3
gene id: 9541:ZZZ3
uniprot id: A0A2K5VFG3
names: Subcellular Location Annotation
messages: Nucleus

9541:CEP76
gene id: 9541:CEP76
uniprot id: A0A2K5VU77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

9541:PPDPFL
gene id: 9541:PPDPFL
uniprot id: A0A2K5VPQ9
names: Similarity
messages: Belongs to the PPDPF family.

9541:ADCY4
gene id: 9541:ADCY4
uniprot id: A0A2K5X5W7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9541:TNFSF8
gene id: 9541:TNFSF8
uniprot id: A0A7N9CVX7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9541:AWAT2
gene id: 9541:AWAT2
uniprot id: A0A8J8XDP5
uniprot id: G7Q2Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9541:RALB
gene id: 9541:RALB
uniprot id: Q4R379
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Interacts with EXOC2/Sec5 and EXOC8/Exo84. Interacts (via effector domain) with RALBP1.
messages: Midbody
messages: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity).
messages: Prenylation is essential for membrane localization.
messages: The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of some geranylgeranyltransferase I inhibitors.

9541:ANHX
gene id: 9541:ANHX
uniprot id: A0A7N9CDR5
names: Subcellular Location Annotation
messages: Nucleus

9541:SCML1
gene id: 9541:SCML1
uniprot id: A0A2K5TNJ0
uniprot id: A0A2K5TNJ3
names: Similarity
messages: Belongs to the SCM family.

9541:CDO1
gene id: 9541:CDO1
uniprot id: G7P830
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9541:CUL1
gene id: 9541:CUL1
uniprot id: A0A7N9CNI7
names: Similarity
messages: Belongs to the cullin family.

9541:LOC102138899
gene id: 9541:LOC102138899
uniprot id: G7NWJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:TGM2
gene id: 9541:TGM2
uniprot id: A0A2K5VXI8
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9541:TARBP2
gene id: 9541:TARBP2
uniprot id: A0A2K5UFU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9541:SERP2
gene id: 9541:SERP2
uniprot id: A0A2K5VW72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9541:RBM5
gene id: 9541:RBM5
uniprot id: A0A2K5UWT9
uniprot id: A0A7N9CXB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9541:LOC102130413
gene id: 9541:LOC102130413
uniprot id: A0A2K5UFX5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9541:ALDH1A2
gene id: 9541:ALDH1A2
uniprot id: A0A2K5U4V1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:GALNT5
gene id: 9541:GALNT5
uniprot id: A0A2K5U6X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9541:FMC1
gene id: 9541:FMC1
uniprot id: A0A2K5WU95
names: Similarity
messages: Belongs to the FMC1 family.

9541:LOC102137744
gene id: 9541:LOC102137744
uniprot id: A0A8J8XQP4
uniprot id: G7P2L5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:NR3C1
gene id: 9541:NR3C1
uniprot id: A0A8J8XPH3
uniprot id: G7P8J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

9541:B3GNT5
gene id: 9541:B3GNT5
uniprot id: A0A2K5UET4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:BTC
gene id: 9541:BTC
uniprot id: A0A2K5X5E5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SYT1
gene id: 9541:SYT1
uniprot id: A0A2K5WAC0
uniprot id: Q60HC0
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity).
messages: Cytoplasm
messages: Glycosylated.
messages: Homotetramer (Probable). Heterodimer; heterodimerizes with SYT2 in presence of calcium (By similarity). Interacts with SCAMP5 (By similarity). Interacts with STON2 (By similarity). Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity). Interacts with SV2A, SV2B and SV2C (By similarity). Interacts with RIMS1 (By similarity). Interacts with PRRT2 (By similarity). Interacts with DNAJC5 in a phosphorylation-dependent manner (By similarity). Interacts (via N-terminus) with RAB3A (By similarity). Interacts with SYT12 (By similarity). Interacts with calmodulin (By similarity).
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
messages: The second C2 domain mediates interaction with SV2A and probably with STN2.
messages: chromaffin granule membrane
messages: secretory vesicle membrane
messages: synaptic vesicle membrane

9541:KCNK9
gene id: 9541:KCNK9
uniprot id: A0A7N9DCV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9541:EIF2S1
gene id: 9541:EIF2S1
uniprot id: A0A8J8XGJ1
uniprot id: G7PAK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9541:GJB3
gene id: 9541:GJB3
uniprot id: G7NTG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:PPP3CA
gene id: 9541:PPP3CA
uniprot id: A0A2K5WC95
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9541:DMTF1
gene id: 9541:DMTF1
uniprot id: A0A2K5TWT6
uniprot id: A0A8J8YSC6
uniprot id: G7P1W2
names: Subcellular Location Annotation
messages: Nucleus

9541:YWHAE
gene id: 9541:YWHAE
uniprot id: Q4R4J3
names: Similarity
messages: Belongs to the 14-3-3 family.

9541:TMEM45B
gene id: 9541:TMEM45B
uniprot id: A0A2K5W1T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9541:MRPS25
gene id: 9541:MRPS25
uniprot id: A0A8J8XC86
uniprot id: G7PIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9541:NETO2
gene id: 9541:NETO2
uniprot id: A0A2K5X8V7
uniprot id: A0A2K5X9A8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:GABRB2
gene id: 9541:GABRB2
uniprot id: A0A2K5X1S8
uniprot id: A0A8J8YKT6
uniprot id: G7P6T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:AREG
gene id: 9541:AREG
uniprot id: A0A2K5U4V6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102139903
gene id: 9541:LOC102139903
uniprot id: A0A2K5UPN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:RIPPLY1
gene id: 9541:RIPPLY1
uniprot id: A0A7N9CJ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9541:CAND1
gene id: 9541:CAND1
uniprot id: A0A8J8Y752
uniprot id: G7PHZ3
names: Similarity
messages: Belongs to the CAND family.

9541:CIAPIN1
gene id: 9541:CIAPIN1
uniprot id: A0A2K5X645
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9541:SH3GL2
gene id: 9541:SH3GL2
uniprot id: A0A2K5VIB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9541:PPP1CB
gene id: 9541:PPP1CB
uniprot id: A0A7N9CGK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9541:VPS25
gene id: 9541:VPS25
uniprot id: A0A2K5V8X3
names: Similarity
messages: Belongs to the VPS25 family.

9541:LOC107127349
gene id: 9541:LOC107127349
uniprot id: A0A7N9D771
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9541:TPM2
gene id: 9541:TPM2
uniprot id: A0A2K5TXJ1
uniprot id: A0A2K5TXK7
uniprot id: G7PS00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9541:TAT
gene id: 9541:TAT
uniprot id: A0A8J8XI10
uniprot id: G7Q1K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9541:SMIM5
gene id: 9541:SMIM5
uniprot id: A0A7N9CHX2
names: Subcellular Location Annotation
messages: Membrane

9541:SSRP1
gene id: 9541:SSRP1
uniprot id: A0A8J8XSE2
uniprot id: G7PQ43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9541:LAMTOR2
gene id: 9541:LAMTOR2
uniprot id: A0A8J8YRM5
uniprot id: G7NV75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9541:KCNMA1
gene id: 9541:KCNMA1
uniprot id: A0A2K5VSL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Membrane

9541:IRAK1BP1
gene id: 9541:IRAK1BP1
uniprot id: A0A2K5V741
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9541:SUMO1
gene id: 9541:SUMO1
uniprot id: I7G9I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9541:CYP7B1
gene id: 9541:CYP7B1
uniprot id: A0A2K5UFH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9541:GPBP1L1
gene id: 9541:GPBP1L1
uniprot id: A0A2K5TSE3
uniprot id: G8F2B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9541:RAB3GAP2
gene id: 9541:RAB3GAP2
uniprot id: A0A8J8Y6F7
uniprot id: G7NTY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

9541:C1GALT1
gene id: 9541:C1GALT1
uniprot id: A0A2K5UWB6
uniprot id: A0A7N9CVW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Membrane

9541:KIF21B
gene id: 9541:KIF21B
uniprot id: A0A2K5WZ21
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:BNIP1
gene id: 9541:BNIP1
uniprot id: A0A2K5W4J6
names: Subcellular Location Annotation
messages: Membrane

9541:ETS1
gene id: 9541:ETS1
uniprot id: A0A2K5TYL4
uniprot id: A0A2K5TYT0
uniprot id: A0A8J8YQS4
uniprot id: G7PPN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus
messages: Transcription factor.

9541:ATP5MF
gene id: 9541:ATP5MF
uniprot id: Q2PFS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9541:NSUN5
gene id: 9541:NSUN5
uniprot id: A0A2K5WIR5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9541:ALDH6A1
gene id: 9541:ALDH6A1
uniprot id: A0A2K5X140
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

9541:C1D
gene id: 9541:C1D
uniprot id: A0A8J8XV92
uniprot id: G7NZK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9541:GPR180
gene id: 9541:GPR180
uniprot id: A0A2K5VJ87
names: Subcellular Location Annotation
messages: Membrane

9541:LRRC7
gene id: 9541:LRRC7
uniprot id: A0A2K5UWW0
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9541:RNASE11
gene id: 9541:RNASE11
uniprot id: G7P9L6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:PPFIA4
gene id: 9541:PPFIA4
uniprot id: A0A2K5U522
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9541:LDB3
gene id: 9541:LDB3
uniprot id: A0A2K5ULR2
names: Subcellular Location Annotation
messages: Z line

9541:ANXA2
gene id: 9541:ANXA2
uniprot id: A0A2K5UQS9
uniprot id: A0A8J8YR13
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

9541:LOC102125550
gene id: 9541:LOC102125550
uniprot id: A0A2K5UEA5
names: Similarity
messages: Belongs to the NDK family.

9541:FAM3B
gene id: 9541:FAM3B
uniprot id: A0A2K5X116
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9541:TMEM150A
gene id: 9541:TMEM150A
uniprot id: A0A8J8YQX1
uniprot id: G7PMM5
names: Subcellular Location Annotation
messages: Membrane

9541:MRPS12
gene id: 9541:MRPS12
uniprot id: A0A8J8XQN7
uniprot id: G7PXI2
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9541:RNFT1
gene id: 9541:RNFT1
uniprot id: A0A2K5VR77
names: Subcellular Location Annotation
messages: Membrane

9541:EPHB1
gene id: 9541:EPHB1
uniprot id: A0A8J8XCA7
uniprot id: G7NXX9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9541:PTGER4
gene id: 9541:PTGER4
uniprot id: Q95J39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9541:FAM91A1
gene id: 9541:FAM91A1
uniprot id: A0A2K5X6H4
names: Similarity
messages: Belongs to the FAM91 family.

9541:NPM1
gene id: 9541:NPM1
uniprot id: A0A2K5VGS6
names: Similarity
messages: Belongs to the nucleoplasmin family.

9541:KCNS3
gene id: 9541:KCNS3
uniprot id: A0A2K5UDN3
uniprot id: G8F573
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:TP63
gene id: 9541:TP63
uniprot id: A0A2K5VC97
uniprot id: A0A2K5VCF3
uniprot id: A0A8J8YGJ4
uniprot id: G7NYP4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Nucleus

9541:RXRB
gene id: 9541:RXRB
uniprot id: A0A2K5WBN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9541:MAP1LC3A
gene id: 9541:MAP1LC3A
uniprot id: I7GLL6
names: Similarity
messages: Belongs to the ATG8 family.

9541:SUPT3H
gene id: 9541:SUPT3H
uniprot id: A0A2K5UI13
names: Subcellular Location Annotation
messages: Nucleus

9541:BTAF1
gene id: 9541:BTAF1
uniprot id: A0A2K5VR83
uniprot id: A0A2K5VRB0
names: Subcellular Location Annotation
messages: Nucleus

9541:ACTC1
gene id: 9541:ACTC1
uniprot id: A0A8J8YL82
uniprot id: G7PAP7
names: Similarity
messages: Belongs to the actin family.

9541:GAPVD1
gene id: 9541:GAPVD1
uniprot id: A0A2K5WA01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9541:ELOVL5
gene id: 9541:ELOVL5
uniprot id: A0A2K5TLG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:PDP1
gene id: 9541:PDP1
uniprot id: A0A7N9CIZ6
uniprot id: A0A7N9D9J9
names: Similarity
messages: Belongs to the PP2C family.

9541:HTR1F
gene id: 9541:HTR1F
uniprot id: A0A8J8YEW1
uniprot id: G7NZ54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

9541:KCNV2
gene id: 9541:KCNV2
uniprot id: A0A2K5WVN7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:SLC25A53
gene id: 9541:SLC25A53
uniprot id: A0A7N9CVE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9541:SNRNP27
gene id: 9541:SNRNP27
uniprot id: A0A7N9DFU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9541:SCOC
gene id: 9541:SCOC
uniprot id: A0A7N9CUY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

9541:RCL1
gene id: 9541:RCL1
uniprot id: A0A8J8Y2J1
uniprot id: G7PSF4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

9541:KIF5A
gene id: 9541:KIF5A
uniprot id: A0A2K5WRA2
uniprot id: A0A8J8YRW8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:LDAF1
gene id: 9541:LDAF1
uniprot id: A0A2K5UTW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9541:CRY1
gene id: 9541:CRY1
uniprot id: A0A8J8XQ28
uniprot id: G7PI44
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

9541:G0S2
gene id: 9541:G0S2
uniprot id: A0A2K5UJD9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.
messages: Mitochondrion
messages: Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.

9541:FASTKD5
gene id: 9541:FASTKD5
uniprot id: Q95KD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAST kinase family.
messages: Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2. Associates with the 12S mitochondrial rRNA (12S mt-rRNA).
messages: Plays an important role in the processing of non-canonical mitochondrial mRNA precursors.
messages: mitochondrion nucleoid

9541:CBWD1
gene id: 9541:CBWD1
uniprot id: A0A2K5VPK4
uniprot id: A0A7N9CTQ2
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9541:HPSE2
gene id: 9541:HPSE2
uniprot id: A0A2K5W315
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9541:POLR3C
gene id: 9541:POLR3C
uniprot id: A0A8J8YM60
uniprot id: G7NX80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9541:HINT1
gene id: 9541:HINT1
uniprot id: A0A2K5TM01
names: Similarity
messages: Belongs to the HINT family.

9541:SF3B6
gene id: 9541:SF3B6
uniprot id: A0A2K5W230
names: Subcellular Location Annotation
messages: Nucleus

9541:TACR1
gene id: 9541:TACR1
uniprot id: A0A2K5VH04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9541:KCNH5
gene id: 9541:KCNH5
uniprot id: A0A8J8XZ53
uniprot id: G7PAH7
names: Subcellular Location Annotation
messages: Membrane

9541:SLC25A32
gene id: 9541:SLC25A32
uniprot id: Q95J75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis.
messages: Mitochondrion inner membrane

9541:MTHFS
gene id: 9541:MTHFS
uniprot id: A0A2K5V823
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

9541:IPO13
gene id: 9541:IPO13
uniprot id: A0A8J8Y1H8
uniprot id: G7NUX7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9541:ETNPPL
gene id: 9541:ETNPPL
uniprot id: A0A2K5UWR7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9541:ASAH2
gene id: 9541:ASAH2
uniprot id: A0A2K5WEH4
names: Similarity
messages: Belongs to the neutral ceramidase family.

9541:PROKR2
gene id: 9541:PROKR2
uniprot id: A0A2K5TRW4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:DERL2
gene id: 9541:DERL2
uniprot id: A0A8J8XH18
uniprot id: G7PTB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PIK3CB
gene id: 9541:PIK3CB
uniprot id: A0A2K5U222
uniprot id: A0A8J8XJE7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9541:EMC6
gene id: 9541:EMC6
uniprot id: A0A2K5UKN3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:SHMT1
gene id: 9541:SHMT1
uniprot id: A0A2K5WHN6
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9541:PTK2B
gene id: 9541:PTK2B
uniprot id: A0A2K5WCP6
uniprot id: A0A2K5WCQ3
uniprot id: A0A8J8Y222
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

9541:IVD
gene id: 9541:IVD
uniprot id: G8F3Q0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9541:EXO5
gene id: 9541:EXO5
uniprot id: A0A8J8YFL1
uniprot id: G7NUD7
names: Similarity
messages: Belongs to the EXO5 family.

9541:EXOSC5
gene id: 9541:EXOSC5
uniprot id: A0A2K5X5R2
names: Subcellular Location Annotation
messages: Cytoplasm

9541:ASB9
gene id: 9541:ASB9
uniprot id: A0A2K5V5D5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:GRB7
gene id: 9541:GRB7
uniprot id: A0A2K5U3C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9541:CLDN6
gene id: 9541:CLDN6
uniprot id: G7Q0B0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:SLC25A5
gene id: 9541:SLC25A5
uniprot id: A0A7N9CAS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9541:PSKH1
gene id: 9541:PSKH1
uniprot id: A0A8J8YA10
uniprot id: G7Q1F3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:RBMX
gene id: 9541:RBMX
uniprot id: Q4R7F0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Arg-185 is dimethylated, probably to asymmetric dimethylarginine.
messages: Homomultimer. Found in the supraspliceosome complex. Identified in the spliceosome C complex. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, NCOA5 and PPP1CA. Interacts with CLK2, KHDRBS2, KHDRBS3, SAFB/SAFB1, TRA2B and YTHDC1. Interacts with ERAP1; the interaction is RNA-independent (By similarity). Interacts with PPIA/CYPA (By similarity).
messages: Nucleus
messages: O-glycosylated.
messages: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity).
messages: The RRM domain is necessary for RNA-binding, but not for splice site selection, indicating that its splicing activity does not require direct binding to RNA.

9541:LOC102133005
gene id: 9541:LOC102133005
uniprot id: A0A2K5X1Z1
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

9541:RIN2
gene id: 9541:RIN2
uniprot id: A0A2K5W721
uniprot id: A0A2K5W777
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9541:NCOA1
gene id: 9541:NCOA1
uniprot id: A0A2K5WUB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9541:ALG13
gene id: 9541:ALG13
uniprot id: A0A2K5VHX9
uniprot id: A0A2K5VHZ5
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

9541:FOXRED1
gene id: 9541:FOXRED1
uniprot id: Q4R510
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with components of the mitochondrial respiratory chain complex I.
messages: Mitochondrion inner membrane
messages: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.

9541:TMEM38B
gene id: 9541:TMEM38B
uniprot id: A0A2K5X7D5
uniprot id: A0A7N9CP35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9541:GABRG2
gene id: 9541:GABRG2
uniprot id: A0A2K5TLM2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:PRDX1
gene id: 9541:PRDX1
uniprot id: A0A2K5UML5
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9541:DYNLRB1
gene id: 9541:DYNLRB1
uniprot id: A0A2K5U3W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9541:SMIM24
gene id: 9541:SMIM24
uniprot id: A0A2K5U1N4
names: Subcellular Location Annotation
messages: Membrane

9541:AIF1L
gene id: 9541:AIF1L
uniprot id: A0A2K5X8V1
names: Subcellular Location Annotation
messages: ruffle membrane

9541:SLC12A5
gene id: 9541:SLC12A5
uniprot id: A0A2K5U2D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9541:CASP8
gene id: 9541:CASP8
uniprot id: A0A2K5WHB0
names: Similarity
messages: Belongs to the peptidase C14A family.

9541:PHACTR2
gene id: 9541:PHACTR2
uniprot id: A0A2K5UGH5
uniprot id: A0A2K5UGL9
uniprot id: A0A2K5UGM6
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9541:RBBP7
gene id: 9541:RBBP7
uniprot id: A0A8J8Y4H5
uniprot id: G7Q2B1
names: Subcellular Location Annotation
messages: Nucleus

9541:INTS7
gene id: 9541:INTS7
uniprot id: A0A2K5WG24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9541:TLE5
gene id: 9541:TLE5
uniprot id: I7GPM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9541:KCNJ8
gene id: 9541:KCNJ8
uniprot id: A0A2K5WG71
uniprot id: G8F4D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9541:SETD7
gene id: 9541:SETD7
uniprot id: A0A2K5TYA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9541:FUT8
gene id: 9541:FUT8
uniprot id: A0A2K5TRW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9541:CCNL2
gene id: 9541:CCNL2
uniprot id: I7GHV1
names: Similarity
messages: Belongs to the cyclin family.

9541:UGDH
gene id: 9541:UGDH
uniprot id: A0A2K5WLS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9541:PPP4R2
gene id: 9541:PPP4R2
uniprot id: A0A2K5VZ74
names: Similarity
messages: Belongs to the PPP4R2 family.

9541:DBT
gene id: 9541:DBT
uniprot id: A0A2K5VT48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9541:SLC17A9
gene id: 9541:SLC17A9
uniprot id: A0A2K5VMG7
names: Subcellular Location Annotation
messages: Membrane

9541:STC2
gene id: 9541:STC2
uniprot id: A0A2K5TR46
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9541:SERINC1
gene id: 9541:SERINC1
uniprot id: A0A8J8Y6V0
uniprot id: G7P394
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9541:DNASE1L2
gene id: 9541:DNASE1L2
uniprot id: A0A2K5V1N6
names: Similarity
messages: Belongs to the DNase I family.

9541:GALT
gene id: 9541:GALT
uniprot id: A0A8J8Y7V6
uniprot id: G7PS28
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9541:THOC7
gene id: 9541:THOC7
uniprot id: A0A2K5V3K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

9541:PDE11A
gene id: 9541:PDE11A
uniprot id: A0A8J8YBB3
uniprot id: G7PKX5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9541:LOC102138242
gene id: 9541:LOC102138242
uniprot id: A0A2K5UD58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:DPYSL5
gene id: 9541:DPYSL5
uniprot id: A0A2K5UN44
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9541:ZKSCAN4
gene id: 9541:ZKSCAN4
uniprot id: A0A2K5UP95
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102140088
gene id: 9541:LOC102140088
uniprot id: A0A2K5V684
names: Similarity
messages: Belongs to the strictosidine synthase family.

9541:ADK
gene id: 9541:ADK
uniprot id: A0A2K5VIG9
uniprot id: A0A7N9D865
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9541:FKTN
gene id: 9541:FKTN
uniprot id: A0A7N9D6T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9541:EREG
gene id: 9541:EREG
uniprot id: A0A2K5UAU1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:TMED2
gene id: 9541:TMED2
uniprot id: A0A2K5TLN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9541:GNG12
gene id: 9541:GNG12
uniprot id: A0A2K5VFG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9541:PFDN2
gene id: 9541:PFDN2
uniprot id: A0A2K5V9W8
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9541:LCA5L
gene id: 9541:LCA5L
uniprot id: A0A8J8YMB0
uniprot id: G7P0Z6
names: Similarity
messages: Belongs to the LCA5 family.

9541:FAM187A
gene id: 9541:FAM187A
uniprot id: A0A8J8YDG6
uniprot id: G7PV11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9541:GPR119
gene id: 9541:GPR119
uniprot id: A0A8J8XTZ9
uniprot id: G7Q3P2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:GDPD1
gene id: 9541:GDPD1
uniprot id: G7PUH0
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9541:CHST4
gene id: 9541:CHST4
uniprot id: A0A7N9CXJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9541:AS3MT
gene id: 9541:AS3MT
uniprot id: A0A7N9D6B9
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

9541:RFX3
gene id: 9541:RFX3
uniprot id: A0A2K5X7D6
uniprot id: A0A2K5X7I3
names: Subcellular Location Annotation
messages: Nucleus

9541:H1-6
gene id: 9541:H1-6
uniprot id: G7P2M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9541:TBC1D23
gene id: 9541:TBC1D23
uniprot id: A0A2K5UTW2
uniprot id: A0A2K5UTY6
uniprot id: A0A2K5UU06
uniprot id: A0A8J8XGF9
names: Subcellular Location Annotation
messages: trans-Golgi network

9541:EWSR1
gene id: 9541:EWSR1
uniprot id: A0A2K5WSC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9541:SSU72
gene id: 9541:SSU72
uniprot id: A0A2K5X3K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9541:FABP4
gene id: 9541:FABP4
uniprot id: A0A8J8YKQ0
uniprot id: G7PC40
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:ITK
gene id: 9541:ITK
uniprot id: A0A2K5X9J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9541:TMED6
gene id: 9541:TMED6
uniprot id: A0A8J8XY41
uniprot id: G7Q1I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:ZC3HC1
gene id: 9541:ZC3HC1
uniprot id: A0A2K5UPS7
names: Subcellular Location Annotation
messages: Nucleus

9541:P2RY4
gene id: 9541:P2RY4
uniprot id: A0A2K5UD43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SUSD4
gene id: 9541:SUSD4
uniprot id: A0A2K5VIA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102119400
gene id: 9541:LOC102119400
uniprot id: A0A2K5X463
uniprot id: Q95LR9
names: Subcellular Location Annotation
messages: Secreted

9541:SSR4
gene id: 9541:SSR4
uniprot id: A0A8J8XAD8
uniprot id: G7Q200
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9541:GPX5
gene id: 9541:GPX5
uniprot id: A0A2K5WDB5
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9541:HMGN3
gene id: 9541:HMGN3
uniprot id: A0A2K5V4W9
uniprot id: A0A2K5V4Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9541:KRT82
gene id: 9541:KRT82
uniprot id: A0A2K5X5C3
names: Similarity
messages: Belongs to the intermediate filament family.

9541:P2RX1
gene id: 9541:P2RX1
uniprot id: A0A2K5WNC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9541:SEC23A
gene id: 9541:SEC23A
uniprot id: A0A2K5UC61
uniprot id: A0A8J8Y3C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9541:TGFB2
gene id: 9541:TGFB2
uniprot id: A0A2K5TZI7
uniprot id: A0A7N9D1Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9541:PPP3R1
gene id: 9541:PPP3R1
uniprot id: A0A7N9D4V0
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9541:ABI2
gene id: 9541:ABI2
uniprot id: A0A2K5UVD3
uniprot id: A0A7N9CIX9
uniprot id: A0A7N9D0E3
uniprot id: A0A7N9DC51
uniprot id: A0A7N9IF93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9541:QRFPR
gene id: 9541:QRFPR
uniprot id: A0A2K5X3X2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:CRYGS
gene id: 9541:CRYGS
uniprot id: A0A2K5TLY3
uniprot id: A0A8J8XT43
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9541:LRP4
gene id: 9541:LRP4
uniprot id: A0A2K5WC84
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:PFDN6
gene id: 9541:PFDN6
uniprot id: A0A8J8YMI4
uniprot id: G7P2S7
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9541:CWC15
gene id: 9541:CWC15
uniprot id: A0A2K5VJY0
names: Similarity
messages: Belongs to the CWC15 family.

9541:GABRG3
gene id: 9541:GABRG3
uniprot id: A0A2K5WT79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:TCP11L1
gene id: 9541:TCP11L1
uniprot id: A0A2K5WU60
names: Similarity
messages: Belongs to the TCP11 family.

9541:SLC5A12
gene id: 9541:SLC5A12
uniprot id: A0A2K5W4K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9541:GRIA4
gene id: 9541:GRIA4
uniprot id: A0A2K5TWT7
uniprot id: A0A2K5TWV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9541:LEPR
gene id: 9541:LEPR
uniprot id: A0A2K5U8P7
uniprot id: A0A2K5U8T0
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9541:ANAPC4
gene id: 9541:ANAPC4
uniprot id: A0A2K5WKI1
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

9541:POU1F1
gene id: 9541:POU1F1
uniprot id: A0A2K5UUK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9541:PPM1L
gene id: 9541:PPM1L
uniprot id: A0A8J8YJJ4
uniprot id: G7NZI0
names: Similarity
messages: Belongs to the PP2C family.

9541:GAPDH
gene id: 9541:GAPDH
uniprot id: A0A0A7KUP9
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

9541:HIGD1B
gene id: 9541:HIGD1B
uniprot id: A0A7N9DBW9
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9541:EPAS1
gene id: 9541:EPAS1
uniprot id: A0A2K5WDY2
names: Subcellular Location Annotation
messages: Nucleus speckle

9541:CCNH
gene id: 9541:CCNH
uniprot id: A0A2K5UEC9
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9541:SLC9A9
gene id: 9541:SLC9A9
uniprot id: A0A8J8YKJ7
uniprot id: G7P004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9541:SLC35B3
gene id: 9541:SLC35B3
uniprot id: A0A2K5X8B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9541:KCTD7
gene id: 9541:KCTD7
uniprot id: A0A2K5X953
names: Subcellular Location Annotation
messages: Cell membrane

9541:IL36RN
gene id: 9541:IL36RN
uniprot id: A0A2K5UWR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9541:ACTR2
gene id: 9541:ACTR2
uniprot id: A0A2K5VKV4
uniprot id: A0A2K5VL34
names: Similarity
messages: Belongs to the actin family.

9541:CDC42SE1
gene id: 9541:CDC42SE1
uniprot id: A0A2K5TSF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9541:CDK7
gene id: 9541:CDK7
uniprot id: A0A2K5TTM9
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9541:NXPH3
gene id: 9541:NXPH3
uniprot id: G7PU90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9541:GABRA3
gene id: 9541:GABRA3
uniprot id: A0A8J8YAB1
uniprot id: G7Q1Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:MEF2D
gene id: 9541:MEF2D
uniprot id: A0A2K5US28
uniprot id: A0A2K5USA9
names: Subcellular Location Annotation
messages: Nucleus

9541:TECRL
gene id: 9541:TECRL
uniprot id: A0A2K5WN39
uniprot id: A0A8J8Y262
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9541:TMEM91
gene id: 9541:TMEM91
uniprot id: A0A2K5UZP0
uniprot id: A0A7N9C7K4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9541:PKP1
gene id: 9541:PKP1
uniprot id: A0A2K5WB38
names: Similarity
messages: Belongs to the beta-catenin family.

9541:CFLAR
gene id: 9541:CFLAR
uniprot id: A0A2K5W001
names: Similarity
messages: Belongs to the peptidase C14A family.

9541:TFB1M
gene id: 9541:TFB1M
uniprot id: A0A8J8Y2R5
uniprot id: G7P4X1
uniprot id: Q2PG46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM (By similarity).
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9541:LYVE1
gene id: 9541:LYVE1
uniprot id: A0A2K5UWG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:FAR2
gene id: 9541:FAR2
uniprot id: A0A7N9I9D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9541:RECQL
gene id: 9541:RECQL
uniprot id: A0A2K5UWF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9541:HOMER1
gene id: 9541:HOMER1
uniprot id: A0A2K5U708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9541:SUN3
gene id: 9541:SUN3
uniprot id: Q95LV7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed to form a spermatogenesis-specific LINC complex with SYNE1 during sperm head formation possibly implicating a SUN domain-based heterotrimer with SPAG4/SUN4 associating with SYNE1.
messages: The short coiled coil domain is proposed to be not involved in load-bearing and force transmission from the cytoskeleton but in mere nucleus anchorage instead.

9541:TRAPPC13
gene id: 9541:TRAPPC13
uniprot id: A0A2K5X667
uniprot id: A0A2K5X6A3
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9541:GABRA4
gene id: 9541:GABRA4
uniprot id: A0A8J8XR95
uniprot id: G7P5I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9541:USP2
gene id: 9541:USP2
uniprot id: A0A2K5U4E6
uniprot id: A0A8J8XDN1
uniprot id: G7PPB3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9541:LOC102140578
gene id: 9541:LOC102140578
uniprot id: A0A2K5X4Q6
names: Similarity
messages: Belongs to the intermediate filament family.

9541:MDGA2
gene id: 9541:MDGA2
uniprot id: A0A2K5V1X5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:CCNC
gene id: 9541:CCNC
uniprot id: A0A2K5USI3
uniprot id: A0A2K5USJ7
names: Similarity
messages: Belongs to the cyclin family.

9541:DERL3
gene id: 9541:DERL3
uniprot id: A0A2K5U6I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9541:SCFD1
gene id: 9541:SCFD1
uniprot id: A0A2K5X101
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9541:ZNF532
gene id: 9541:ZNF532
uniprot id: A0A2K5UK98
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:RPS7
gene id: 9541:RPS7
uniprot id: A0A2K5W178
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: centrosome

9541:CDH8
gene id: 9541:CDH8
uniprot id: G7Q1A7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:COPS7B
gene id: 9541:COPS7B
uniprot id: A0A2K5WYS7
uniprot id: A0A7N9CBY3
uniprot id: A0A7N9D9U6
uniprot id: A0A8J8XMR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9541:ANXA11
gene id: 9541:ANXA11
uniprot id: A0A2K5VTK4
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9541:NECAP2
gene id: 9541:NECAP2
uniprot id: A0A2K5U244
uniprot id: A0A2K5U268
uniprot id: A0A2K5U270
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9541:RAB9A
gene id: 9541:RAB9A
uniprot id: A0A8J8Y101
uniprot id: G7Q287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9541:SLC13A5
gene id: 9541:SLC13A5
uniprot id: A0A8J8Y478
uniprot id: G7PTE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9541:TOM1L1
gene id: 9541:TOM1L1
uniprot id: A0A8J8YAH0
uniprot id: G7PUC6
names: Similarity
messages: Belongs to the TOM1 family.

9541:SLC17A2
gene id: 9541:SLC17A2
uniprot id: A0A2K5W5L8
uniprot id: A0A8J8YQC8
uniprot id: G7P2K8
names: Subcellular Location Annotation
messages: Membrane

9541:AKR1A1
gene id: 9541:AKR1A1
uniprot id: A0A2K5W354
uniprot id: A0A2K5W359
uniprot id: G8F2B0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Cell membrane
messages: Membrane
messages: Monomer.
messages: cytosol

9541:LAP3
gene id: 9541:LAP3
uniprot id: A0A2K5X7V5
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9541:RABEP2
gene id: 9541:RABEP2
uniprot id: Q4R6D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

9541:PPP4R3C
gene id: 9541:PPP4R3C
uniprot id: G7Q2E9
names: Similarity
messages: Belongs to the SMEK family.

9541:ARMCX1
gene id: 9541:ARMCX1
uniprot id: A0A8J8XJD7
uniprot id: G7Q398
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9541:NETO1
gene id: 9541:NETO1
uniprot id: A0A8J8XHI9
uniprot id: Q2PFY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:IFIH1
gene id: 9541:IFIH1
uniprot id: A0A2K5WCB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9541:SLC48A1
gene id: 9541:SLC48A1
uniprot id: A0A2K5WP10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

9541:FAM168B
gene id: 9541:FAM168B
uniprot id: A0A2K5WWF8
uniprot id: A0A7N9CS80
names: Similarity
messages: Belongs to the FAM168 family.

9541:KCNK16
gene id: 9541:KCNK16
uniprot id: A0A2K5W678
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9541:PTX3
gene id: 9541:PTX3
uniprot id: A0A2K5WEN7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:DAZAP2
gene id: 9541:DAZAP2
uniprot id: A0A2K5U9I9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9541:ZBED9
gene id: 9541:ZBED9
uniprot id: A0A2K5VS64
names: Subcellular Location Annotation
messages: Nucleus

9541:S100B
gene id: 9541:S100B
uniprot id: A0A8J8YNZ8
uniprot id: G7PWM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9541:TUBE1
gene id: 9541:TUBE1
uniprot id: A0A8J8Y2S7
uniprot id: G7P3M6
names: Similarity
messages: Belongs to the tubulin family.

9541:LOC102117303
gene id: 9541:LOC102117303
uniprot id: A0A7N9CI04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9541:MUSTN1
gene id: 9541:MUSTN1
uniprot id: A0A2K5WL93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9541:CCNA1
gene id: 9541:CCNA1
uniprot id: A0A2K5VBK9
uniprot id: Q4R337
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9541:SDHAF3
gene id: 9541:SDHAF3
uniprot id: A0A2K5UQN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9541:MCTP1
gene id: 9541:MCTP1
uniprot id: A0A2K5X4T4
uniprot id: A0A2K5X4Y1
names: Subcellular Location Annotation
messages: Membrane

9541:ZDHHC23
gene id: 9541:ZDHHC23
uniprot id: A0A2K5U1H6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:KCNH7
gene id: 9541:KCNH7
uniprot id: A0A2K5URQ5
names: Subcellular Location Annotation
messages: Membrane

9541:ACP7
gene id: 9541:ACP7
uniprot id: A0A2K5WEP7
uniprot id: A0A8J8XKK7
uniprot id: G7PXI5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9541:TMSB15A
gene id: 9541:TMSB15A
uniprot id: A0A8J8XD17
uniprot id: G7Q3A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9541:CHURC1
gene id: 9541:CHURC1
uniprot id: A0A2K5WSH3
names: Similarity
messages: Belongs to the Churchill family.

9541:DUSP26
gene id: 9541:DUSP26
uniprot id: A0A2K5VVD9
uniprot id: A0A2K5VVF9
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9541:MAP2
gene id: 9541:MAP2
uniprot id: A0A2K5W6F5
uniprot id: A0A2K5W6L6
uniprot id: A0A7N9DEN1
uniprot id: G7PLB5
names: Subcellular Location Annotation
messages: cytoskeleton

9541:GAB2
gene id: 9541:GAB2
uniprot id: A0A2K5WAB8
names: Similarity
messages: Belongs to the GAB family.

9541:FSCN3
gene id: 9541:FSCN3
uniprot id: A0A2K5W420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9541:GRIN3A
gene id: 9541:GRIN3A
uniprot id: A0A2K5VQ27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9541:ATP6V0E1
gene id: 9541:ATP6V0E1
uniprot id: A0A8J8XJT8
uniprot id: G7P6X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:SENP8
gene id: 9541:SENP8
uniprot id: A0A8J8YN89
uniprot id: G7P914
names: Similarity
messages: Belongs to the peptidase C48 family.

9541:LOC101866922
gene id: 9541:LOC101866922
uniprot id: A0A2K5UU73
names: Function
names: Subcellular Location Annotation
messages: Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Secreted

9541:NDFIP2
gene id: 9541:NDFIP2
uniprot id: A0A2K5WAN9
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9541:PIERCE1
gene id: 9541:PIERCE1
uniprot id: A0A2K5VCQ0
uniprot id: G8F5E5
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9541:NTMT2
gene id: 9541:NTMT2
uniprot id: A0A8J8Y5J0
uniprot id: G7P656
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9541:RNASE10
gene id: 9541:RNASE10
uniprot id: A0A7N9CQW9
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9541:PRPF19
gene id: 9541:PRPF19
uniprot id: A0A2K5W3D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9541:TLR7
gene id: 9541:TLR7
uniprot id: B3Y652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9541:TRMT6
gene id: 9541:TRMT6
uniprot id: A0A8J8XZJ3
uniprot id: G7PGX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9541:CCT3
gene id: 9541:CCT3
uniprot id: A0A8J8YRI3
uniprot id: Q25QN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
messages: Cytoplasm

9541:GHR
gene id: 9541:GHR
uniprot id: A0A2K5WH01
uniprot id: A0A7N9D090
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

9541:CCDC47
gene id: 9541:CCDC47
uniprot id: A0A2K5WED9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC47 family.
messages: Rough endoplasmic reticulum membrane

9541:HOXC9
gene id: 9541:HOXC9
uniprot id: A0A2K5VZ58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9541:MOB3A
gene id: 9541:MOB3A
uniprot id: A0A2K5W9A1
names: Similarity
messages: Belongs to the MOB1/phocein family.

9541:LCLAT1
gene id: 9541:LCLAT1
uniprot id: A0A2K5W176
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9541:DKKL1
gene id: 9541:DKKL1
uniprot id: A0A2K5WPQ3
uniprot id: G7PY70
names: Subcellular Location Annotation
messages: Secreted

9541:DHRS3
gene id: 9541:DHRS3
uniprot id: A0A8J8Y406
uniprot id: G7NU67
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:TBX20
gene id: 9541:TBX20
uniprot id: A0A8J8Y975
uniprot id: G7P0F2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:LOC102126517
gene id: 9541:LOC102126517
uniprot id: A0A7N9D902
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9541:CRISP1
gene id: 9541:CRISP1
uniprot id: A0A2K5U1H1
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:HTR1E
gene id: 9541:HTR1E
uniprot id: A0A8J8YCP3
uniprot id: G7P3J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SH3BGRL
gene id: 9541:SH3BGRL
uniprot id: G7Q351
uniprot id: Q4R7R5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.
messages: Belongs to the SH3BGR family.
messages: Cell membrane
messages: Monomer. Interacts with PFN1/Profilin-1. Interacts with ERBB2. Interacts with ATG12. Interacts with BECN1. Interacts with translating ribosomes.
messages: The SH3-binding domain is buried in the tertiary structure, and it therefore unclear whether it directly mediates protein-binding.
messages: cytosol

9541:IL25
gene id: 9541:IL25
uniprot id: A0A2K5TY65
uniprot id: G7P9V9
names: Similarity
messages: Belongs to the IL-17 family.

9541:RAB8A
gene id: 9541:RAB8A
uniprot id: Q4R5P1
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus
messages: Interacts (GTP-bound form) with MICALL1; regulates RAB8A association with recycling endosomes (By similarity). Interacts with MICALL2; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts (GTP-bound form) with MICAL1, MICALCL, MICAL3 and EHBP1L1; two molecules of RAB8A can bind to one molecule of the effector protein; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible (By similarity). Interacts (GTP-bound form) with EHBP1 (By similarity). Interacts with EHD1 (By similarity). Interacts with MAP4K2 and SYTL4 (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with RABIF, RIMS2, RPH3A and RPH3A (By similarity). Interacts with OPTN (By similarity). Interacts with RAB3IP (By similarity). Interacts with MYO5B (By similarity). Interacts with CIMAP3 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with OCRL (By similarity). Interacts with AHI1 (By similarity). Interacts with DCDC1 (By similarity). Interacts with LRRK2; interaction facilitates phosphorylation of Thr-72 (By similarity). Interacts with RAB31P, GDI1, GDI2, CHM, CHML, RABGGTA, RABGGTB, TBC1D15 and INPP5B; these interactions are dependent on Thr-72 not being phosphorylated (By similarity). Interacts with RILPL1 and RILPL2; these interactions are dependent on the phosphorylation of Thr-72 by LRRK2 (By similarity). Interacts with DZIP1; prevents inhibition by the GDP-dissociation inhibitor GDI2 (By similarity).
messages: Midbody
messages: Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
messages: Recycling endosome membrane
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase (By similarity). Activated in response to insulin (By similarity).
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi (By similarity). Together with MYO5B and RAB11A participates in epithelial cell polarization. Also involved in membrane trafficking to the cilium and ciliogenesis (By similarity). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (By similarity).
messages: centriole
messages: cilium
messages: cilium basal body
messages: phagosome membrane

9541:METTL4
gene id: 9541:METTL4
uniprot id: G7PWG2
names: Similarity
messages: Belongs to the MT-A70-like family.

9541:DAPK2
gene id: 9541:DAPK2
uniprot id: A0A2K5ULA9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:LOC102124448
gene id: 9541:LOC102124448
uniprot id: A0A2K5W923
names: Similarity
messages: Belongs to the GAGE family.

9541:MYO1B
gene id: 9541:MYO1B
uniprot id: A0A2K5VJ33
uniprot id: A0A2K5VJ37
uniprot id: A0A8J8XWY6
uniprot id: G7PL24
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:APPL1
gene id: 9541:APPL1
uniprot id: A0A2K5UAJ3
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9541:PTPRB
gene id: 9541:PTPRB
uniprot id: A0A2K5U774
uniprot id: A0A2K5U787
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9541:FBXO34
gene id: 9541:FBXO34
uniprot id: A0A2K5UEC7
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9541:SEPTIN3
gene id: 9541:SEPTIN3
uniprot id: A0A2K5X3R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:SLCO1B3
gene id: 9541:SLCO1B3
uniprot id: L7TAY6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:FGF12
gene id: 9541:FGF12
uniprot id: A0A2K5TKY5
uniprot id: A0A2K5TKY9
uniprot id: A0A8J8XQD2
uniprot id: G7NYQ4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:LOC102123375
gene id: 9541:LOC102123375
uniprot id: A0A2K5WUC1
uniprot id: A0A2K5WUC7
names: Similarity
messages: Belongs to the Luc7 family.

9541:EXT1
gene id: 9541:EXT1
uniprot id: A0A2K5TXF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:SUPT5H
gene id: 9541:SUPT5H
uniprot id: A0A2K5WQ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus

9541:PRORP
gene id: 9541:PRORP
uniprot id: Q4R366
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPR family. P subfamily.
messages: Binds 2 Mg(2+) or Mg(2+) ions per subunit.
messages: Catalytic component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3.
messages: Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends.
messages: Degraded by LONP1 following mitochondrial unfolded protein response, probably leading to inhibit translation in mitochondrion.
messages: Displays a distorted and non-productive active site that probably switches to a fully productive state only upon association with TRMT10C/MRPP1, HSD17B10/MRPP2 and pre-tRNA substrate.
messages: Mitochondrion

9541:FAM110B
gene id: 9541:FAM110B
uniprot id: A0A8J8XF66
uniprot id: G7PBW3
names: Similarity
messages: Belongs to the FAM110 family.

9541:TIMELESS
gene id: 9541:TIMELESS
uniprot id: A0A2K5UPM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

9541:SETDB2
gene id: 9541:SETDB2
uniprot id: A0A2K5V3M8
names: Subcellular Location Annotation
messages: Chromosome

9541:KLHL3
gene id: 9541:KLHL3
uniprot id: A0A2K5WGW0
uniprot id: A0A7N9D103
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KLHL3 family.
messages: cytoskeleton
messages: cytosol

9541:AMER1
gene id: 9541:AMER1
uniprot id: G7Q2W4
names: Similarity
messages: Belongs to the Amer family.

9541:OAZ1
gene id: 9541:OAZ1
uniprot id: A0A7N9CEE9
names: Similarity
messages: Belongs to the ODC antizyme family.

9541:LOC102132250
gene id: 9541:LOC102132250
uniprot id: A0A2K5WJZ0
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9541:LOC102118065
gene id: 9541:LOC102118065
uniprot id: A0A2K5UJS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9541:HMX2
gene id: 9541:HMX2
uniprot id: A0A7N9CFD7
names: Subcellular Location Annotation
messages: Nucleus

9541:EMP3
gene id: 9541:EMP3
uniprot id: A0A2K5V5C5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9541:GPR17
gene id: 9541:GPR17
uniprot id: A0A2K5W356
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:UNC5B
gene id: 9541:UNC5B
uniprot id: A0A2K5VIX7
uniprot id: A0A2K5VJ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9541:SYCP3
gene id: 9541:SYCP3
uniprot id: Q4R764
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XLR/SYCP3 family.
messages: Chromosome
messages: Component of the lateral elements of synaptonemal complexes (By similarity). Homotetramer; the tetrameric helix bundles assemble end to end into long homopolimeric fibers that exhibit a transversal striation with a periodicity of about 20 nm (in vitro) (By similarity). Interacts with SYCP2 (By similarity). Forms a complex with EWSR1, PRDM9, REC8 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity).
messages: Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.
messages: Composed of a long central coiled coil domain. The N-terminal and C-terminal regions interact with DNA.
messages: Nucleus
messages: Phosphorylated.
messages: centromere

9541:ENTPD7
gene id: 9541:ENTPD7
uniprot id: A0A2K5X1J8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9541:ERMN
gene id: 9541:ERMN
uniprot id: A0A8J8YRE1
uniprot id: G7PKL9
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9541:FLVCR2
gene id: 9541:FLVCR2
uniprot id: A0A2K5X507
uniprot id: A0A7N9CV21
uniprot id: A0A7N9IDF1
names: Subcellular Location Annotation
messages: Membrane

9541:RNF111
gene id: 9541:RNF111
uniprot id: A0A8J8XF14
uniprot id: G7PBK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

9541:HMGCS2
gene id: 9541:HMGCS2
uniprot id: A0A2K5VHJ3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9541:GTF2H4
gene id: 9541:GTF2H4
uniprot id: A0A2K5UIY7
uniprot id: A0A8J8YN01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9541:MAGOHB
gene id: 9541:MAGOHB
uniprot id: A0A2K5V0C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9541:CDC14A
gene id: 9541:CDC14A
uniprot id: A0A2K5X9F1
uniprot id: G7NV31
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9541:SLC5A6
gene id: 9541:SLC5A6
uniprot id: A0A2K5UVT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9541:TSPAN3
gene id: 9541:TSPAN3
uniprot id: A0A2K5UZ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:RPL21
gene id: 9541:RPL21
uniprot id: A0A2K5UG77
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9541:AMIGO2
gene id: 9541:AMIGO2
uniprot id: A0A8J8XCC5
uniprot id: G7PHN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9541:RGN
gene id: 9541:RGN
uniprot id: A0A8J8Y0M3
uniprot id: G7Q2K7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm
messages: Monomer.

9541:VPS45
gene id: 9541:VPS45
uniprot id: G7NTS3
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9541:GCNT4
gene id: 9541:GCNT4
uniprot id: A0A2K5UCK1
uniprot id: G7P7R4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9541:EIF1
gene id: 9541:EIF1
uniprot id: A0A2K5WRG3
uniprot id: A0A8J8XC80
names: Similarity
messages: Belongs to the SUI1 family.

9541:SST
gene id: 9541:SST
uniprot id: A0A8J8Y0N9
uniprot id: G7NYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9541:BCKDK
gene id: 9541:BCKDK
uniprot id: A0A8J8YQ84
uniprot id: Q95LS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9541:GNAT3
gene id: 9541:GNAT3
uniprot id: A0A2K5U8X8
uniprot id: A0A8J8XRP4
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9541:SEC24A
gene id: 9541:SEC24A
uniprot id: A0A2K5W3V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9541:PLPP5
gene id: 9541:PLPP5
uniprot id: A0A2K5WD95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9541:SPIN3
gene id: 9541:SPIN3
uniprot id: G8F4G1
names: Similarity
messages: Belongs to the SPIN/STSY family.

9541:LOC101926003
gene id: 9541:LOC101926003
uniprot id: A0A7N9D8L8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

9541:MALSU1
gene id: 9541:MALSU1
uniprot id: A0A2K5VHP6
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9541:ATG4A
gene id: 9541:ATG4A
uniprot id: A0A2K5X4I7
uniprot id: A0A2K5X4K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9541:LOC102124401
gene id: 9541:LOC102124401
uniprot id: A0A2K5VIW7
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

9541:SLC39A8
gene id: 9541:SLC39A8
uniprot id: A0A7N9IBY7
names: Subcellular Location Annotation
messages: Membrane

9541:KCTD14
gene id: 9541:KCTD14
uniprot id: A0A8J8Y5I7
uniprot id: G7PNB4
names: Subcellular Location Annotation
messages: Cell membrane

9541:PI4KB
gene id: 9541:PI4KB
uniprot id: A0A2K5UC81
uniprot id: A0A2K5UC84
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9541:COQ8B
gene id: 9541:COQ8B
uniprot id: A0A2K5WMA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane

9541:KEG98 p08
gene id: 9541:KEG98_p08
uniprot id: C3W4Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9541:YIPF6
gene id: 9541:YIPF6
uniprot id: A0A8J8XVC8
uniprot id: G7Q2X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:LOC102120931
gene id: 9541:LOC102120931
uniprot id: A0A8J8Y0H3
uniprot id: G7PCD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9541:GOSR1
gene id: 9541:GOSR1
uniprot id: A0A7N9DD30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9541:ALX1
gene id: 9541:ALX1
uniprot id: A0A8J8YN78
uniprot id: G7PIK8
names: Subcellular Location Annotation
messages: Nucleus

9541:EMP1
gene id: 9541:EMP1
uniprot id: A0A2K5VF24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9541:TRIM15
gene id: 9541:TRIM15
uniprot id: A0A2K5UBH5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:TSC22D1
gene id: 9541:TSC22D1
uniprot id: Q4R4H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TSC-22/Dip/Bun family.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterodimer with TSC22D4/THG1 (By similarity). Interacts with histone H1-2 (By similarity). Interacts with GNL3 (By similarity).
messages: Forms a heterodimer with TSC22D4/THG1.
messages: Forms homodimers (By similarity). Forms heterodimers (By similarity). Component of a complex composed of TSC22D1 (via N-terminus), TGFBR1 and TGFBR2; the interaction between TSC22D1 and TGFBR1 is inhibited by SMAD7 and promoted by TGFB1 (By similarity). Interacts with SMAD7; the interaction requires TGF-beta and the interaction is inhibited by TGFBR1 (By similarity). Interacts with TPT1/fortilin; interaction results in the destabilization of TSC22D1 protein and prevents TSC22D1-mediated apoptosis (By similarity). Interacts with SMAD4 (via N-terminus) (By similarity). Interacts with ACVRL1/ALK1, ACVR1/ALK2, BMPR1A/ALK3, ACVR1B/ALK4, BMPR1B/ALK6, ACVR2A/ACTRII, and BMPR2 (By similarity). Interacts with SMAD6 (By similarity). Interacts with TFE3; the interaction is enhanced in the presence of TGF-beta (By similarity).
messages: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells.
messages: Mitochondrion
messages: Nucleus
messages: Positively regulates cell death in response to TGFB3 during mammary gland involution.
messages: Transcriptional repressor (By similarity). Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). Acts to promote CASP3-mediated apoptosis (By similarity). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (By similarity). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (By similarity). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (By similarity).

9541:SRRT
gene id: 9541:SRRT
uniprot id: A0A2K5VDU6
uniprot id: G8F583
names: Similarity
messages: Belongs to the ARS2 family.

9541:FAM110A
gene id: 9541:FAM110A
uniprot id: A0A2K5UP52
names: Similarity
messages: Belongs to the FAM110 family.

9541:FUCA2
gene id: 9541:FUCA2
uniprot id: A0A7N9CHN9
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9541:GIPC1
gene id: 9541:GIPC1
uniprot id: G7PZL8
names: Similarity
messages: Belongs to the GIPC family.

9541:ACSM1
gene id: 9541:ACSM1
uniprot id: G7Q0M8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:ATP6V1C1
gene id: 9541:ATP6V1C1
uniprot id: G7PCG4
uniprot id: Q4R5H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9541:NUP58
gene id: 9541:NUP58
uniprot id: Q4R7P1
names: Subcellular Location Annotation
messages: nuclear pore complex

9541:STIM1
gene id: 9541:STIM1
uniprot id: A0A2K5X2B5
uniprot id: A0A2K5X2B6
uniprot id: A0A8J8Y995
uniprot id: G7PQZ7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:KCNV1
gene id: 9541:KCNV1
uniprot id: G7PCI9
uniprot id: Q9GKU7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Cell membrane
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

9541:PHB2
gene id: 9541:PHB2
uniprot id: A0A2K5W040
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9541:TMEM150C
gene id: 9541:TMEM150C
uniprot id: A0A2K5ULK2
uniprot id: A0A2K5ULQ0
uniprot id: A0A7N9CHJ6
names: Subcellular Location Annotation
messages: Membrane

9541:OTUB1
gene id: 9541:OTUB1
uniprot id: A0A2K5U6T3
names: Similarity
messages: Belongs to the peptidase C65 family.

9541:PCYT1B
gene id: 9541:PCYT1B
uniprot id: A0A2K5U167
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9541:IRAK4
gene id: 9541:IRAK4
uniprot id: A0A2K5V3Y9
uniprot id: A0A2K5V433
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9541:AGTR2
gene id: 9541:AGTR2
uniprot id: A0A8J8XX36
uniprot id: G7Q3I3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

9541:YME1L1
gene id: 9541:YME1L1
uniprot id: Q4R4Z4
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9541:KCTD18
gene id: 9541:KCTD18
uniprot id: A0A8J8XEL6
uniprot id: G7PL53
names: Subcellular Location Annotation
messages: Cell membrane

9541:ALKAL1
gene id: 9541:ALKAL1
uniprot id: A0A8J8XRI4
uniprot id: G7PBU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9541:LOC102127963
gene id: 9541:LOC102127963
uniprot id: A0A2K5UIM1
names: Similarity
messages: Belongs to the intermediate filament family.

9541:TOMM7
gene id: 9541:TOMM7
uniprot id: A0A7N9D4I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9541:DPM3
gene id: 9541:DPM3
uniprot id: G7NV63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

9541:MBOAT1
gene id: 9541:MBOAT1
uniprot id: A0A2K5U0Q0
names: Subcellular Location Annotation
messages: Membrane

9541:CXCL12
gene id: 9541:CXCL12
uniprot id: A0A2K5WXU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:CTLA4
gene id: 9541:CTLA4
uniprot id: A0A2K5W1Z9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9541:LOC102124330
gene id: 9541:LOC102124330
uniprot id: A0A2K5W6D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9541:CNKSR2
gene id: 9541:CNKSR2
uniprot id: A0A2K5WKI3
uniprot id: A0A2K5WKN7
uniprot id: A0A2K5WKU7
names: Similarity
messages: Belongs to the CNKSR family.

9541:LOC102139204
gene id: 9541:LOC102139204
uniprot id: A0A2K5V4R6
uniprot id: G8F302
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antimicrobial protein that is an integral component of the innate immune system (By similarity). Binds to bacterial lipopolysaccharides (LPS) (By similarity). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (By similarity). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (By similarity). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro).
messages: Belongs to the cathelicidin family.
messages: Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).
messages: Monomer, homodimer or homotrimer (in vitro) (By similarity). Oligomerizes as tetra- or hexamer in solution (in vitro).
messages: Secreted
messages: Vesicle

9541:MCIDAS
gene id: 9541:MCIDAS
uniprot id: A0A7N9DC94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9541:C4H6orf89
gene id: 9541:C4H6orf89
uniprot id: A0A7N9CFN8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9541:OPALIN
gene id: 9541:OPALIN
uniprot id: A0A2K5VDN3
uniprot id: A0A7N9D3J9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9541:NOVA1
gene id: 9541:NOVA1
uniprot id: A0A2K5U3P4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus

9541:ST8SIA2
gene id: 9541:ST8SIA2
uniprot id: A0A2K5U7F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:LOC102147063
gene id: 9541:LOC102147063
uniprot id: A0A2K5U042
names: Similarity
messages: Belongs to the folate receptor family.

9541:LOC102115085
gene id: 9541:LOC102115085
uniprot id: A0A2K5UAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:GABRA2
gene id: 9541:GABRA2
uniprot id: A0A2K5WF04
uniprot id: A0A2K5WF28
uniprot id: A0A7N9DDH1
uniprot id: G8F2J4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9541:MOB3C
gene id: 9541:MOB3C
uniprot id: A0A2K5UZ90
names: Similarity
messages: Belongs to the MOB1/phocein family.

9541:TMEM50A
gene id: 9541:TMEM50A
uniprot id: A0A2K5TLA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9541:STIM2
gene id: 9541:STIM2
uniprot id: A0A2K5X1T5
uniprot id: A0A2K5X1T8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:LOC102131808
gene id: 9541:LOC102131808
uniprot id: A0A8J8YQ24
uniprot id: G7PP05
names: Similarity
messages: Belongs to the NXPE family.

9541:ACSS1
gene id: 9541:ACSS1
uniprot id: A0A2K5W7L5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:ILDR1
gene id: 9541:ILDR1
uniprot id: A0A8J8Y1N8
uniprot id: G7NXR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9541:CALHM1
gene id: 9541:CALHM1
uniprot id: G7PDW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9541:PNPT1
gene id: 9541:PNPT1
uniprot id: A0A2K5TWJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm

9541:SLC8A3
gene id: 9541:SLC8A3
uniprot id: A0A2K5U1S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9541:FGF13
gene id: 9541:FGF13
uniprot id: A0A2K5UQV6
uniprot id: A0A2K5UQV7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9541:LOC102115444
gene id: 9541:LOC102115444
uniprot id: A0A2K5WBL4
names: Similarity
messages: Belongs to the synaptotagmin family.

9541:REEP2
gene id: 9541:REEP2
uniprot id: A0A2K5W174
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:MYO5C
gene id: 9541:MYO5C
uniprot id: A0A2K5U346
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9541:LOC102136134
gene id: 9541:LOC102136134
uniprot id: A0A2K5U5A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:SVOPL
gene id: 9541:SVOPL
uniprot id: A0A2K5TNH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9541:ELOF1
gene id: 9541:ELOF1
uniprot id: A0A2K5VJK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9541:EPHB3
gene id: 9541:EPHB3
uniprot id: A0A2K5W4J4
names: Subcellular Location Annotation
messages: Membrane

9541:DNMT3A
gene id: 9541:DNMT3A
uniprot id: A0A2K5UUG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

9541:LIPI
gene id: 9541:LIPI
uniprot id: A0A2K5TZA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9541:AP5M1
gene id: 9541:AP5M1
uniprot id: Q4R6Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.
messages: Belongs to the adaptor complexes medium subunit family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.
messages: cytosol

9541:EIF4E2
gene id: 9541:EIF4E2
uniprot id: A0A2K5U0X6
uniprot id: A0A2K5U110
uniprot id: G7PKB1
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9541:SLC25A4
gene id: 9541:SLC25A4
uniprot id: A0A2K5V3Q3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9541:GTSF1
gene id: 9541:GTSF1
uniprot id: Q4R8M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0224 (FAM112) family.
messages: Cytoplasm
messages: Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.

9541:CHCHD7
gene id: 9541:CHCHD7
uniprot id: Q8SPI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHCHD7 family.
messages: Mitochondrion intermembrane space
messages: Monomer.

9541:KIF3C
gene id: 9541:KIF3C
uniprot id: A0A8J8XNX6
uniprot id: G7PLS9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:CCNT2
gene id: 9541:CCNT2
uniprot id: A0A2K5TJJ9
uniprot id: A0A8J8XC66
uniprot id: G7PN36
names: Similarity
messages: Belongs to the cyclin family.

9541:ALDH3B1
gene id: 9541:ALDH3B1
uniprot id: A0A7N9CJD7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:FUT7
gene id: 9541:FUT7
uniprot id: A0A2K5UWX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9541:TEC
gene id: 9541:TEC
uniprot id: A0A2K5TW50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9541:CYFIP2
gene id: 9541:CYFIP2
uniprot id: A0A2K5WQ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9541:SMC2
gene id: 9541:SMC2
uniprot id: A0A8J8XL17
uniprot id: G7PRT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

9541:MYOZ2
gene id: 9541:MYOZ2
uniprot id: A0A2K5X6N6
names: Similarity
messages: Belongs to the myozenin family.

9541:ESRRG
gene id: 9541:ESRRG
uniprot id: A0A2K5UC83
uniprot id: A0A7N9D2N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9541:LOC102137006
gene id: 9541:LOC102137006
uniprot id: G8F3D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:SAP130
gene id: 9541:SAP130
uniprot id: A0A2K5U1X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9541:SLC46A3
gene id: 9541:SLC46A3
uniprot id: A0A2K5UNL8
names: Subcellular Location Annotation
messages: Membrane

9541:HS3ST5
gene id: 9541:HS3ST5
uniprot id: A0A2K5VC73
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9541:HNRNPA1
gene id: 9541:HNRNPA1
uniprot id: A0A2K5UWM9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9541:PRPF3
gene id: 9541:PRPF3
uniprot id: A0A2K5WYM8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9541:ARL9
gene id: 9541:ARL9
uniprot id: A0A2K5X4B6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9541:SLC39A6
gene id: 9541:SLC39A6
uniprot id: A0A2K5WH46
names: Subcellular Location Annotation
messages: Membrane

9541:TMEM205
gene id: 9541:TMEM205
uniprot id: A0A8J8XMN7
uniprot id: G7PZE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9541:LOC102124928
gene id: 9541:LOC102124928
uniprot id: G7P1K8
uniprot id: Q4W7G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9541:LRRC8E
gene id: 9541:LRRC8E
uniprot id: A0A2K5WKZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9541:GNAT2
gene id: 9541:GNAT2
uniprot id: A0A8J8XJM5
uniprot id: G7NW35
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9541:TMEM87A
gene id: 9541:TMEM87A
uniprot id: A0A2K5WC65
uniprot id: A0A8J8XB06
names: Subcellular Location Annotation
messages: Membrane

9541:GPD1
gene id: 9541:GPD1
uniprot id: A0A8J8YJY8
uniprot id: G7PIA0
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9541:ATP5MK
gene id: 9541:ATP5MK
uniprot id: A0A2K5WIY4
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

9541:LHX5
gene id: 9541:LHX5
uniprot id: A0A2K5W2A3
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC102127506
gene id: 9541:LOC102127506
uniprot id: A0A8J8XD68
uniprot id: G7Q1V3
names: Similarity
messages: Belongs to the SPAN-X family.

9541:TSPAN14
gene id: 9541:TSPAN14
uniprot id: A0A2K5X647
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:SEC13
gene id: 9541:SEC13
uniprot id: A0A2K5W5M8
uniprot id: A0A8J8XDY5
uniprot id: G7NYT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane

9541:CLDN7
gene id: 9541:CLDN7
uniprot id: A0A2K5WU76
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:PRDM14
gene id: 9541:PRDM14
uniprot id: A0A8J8YSJ2
uniprot id: G7PC03
names: Subcellular Location Annotation
messages: Nucleus

9541:CHD1
gene id: 9541:CHD1
uniprot id: A0A2K5UW80
uniprot id: A0A8J8XLE1
uniprot id: G7P802
names: Subcellular Location Annotation
messages: Nucleus

9541:ZSCAN32
gene id: 9541:ZSCAN32
uniprot id: A0A2K5TTN5
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:LOC102136612
gene id: 9541:LOC102136612
uniprot id: A0A2K5UE17
names: Similarity
messages: Belongs to the histone H2B family.

9541:CD3E
gene id: 9541:CD3E
uniprot id: A0A2K5TR65
uniprot id: A0A2K5TR92
uniprot id: Q95LI5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Membrane
messages: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
messages: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6. Interacts with NCK1. Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation.

9541:EXTL1
gene id: 9541:EXTL1
uniprot id: A0A2K5UWW7
uniprot id: A0A2K5UX31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:SLC45A2
gene id: 9541:SLC45A2
uniprot id: A0A2K5WDB3
names: Subcellular Location Annotation
messages: Membrane

9541:METAP2
gene id: 9541:METAP2
uniprot id: A0A2K5WZJ5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9541:EMC3
gene id: 9541:EMC3
uniprot id: A0A2K5TWC4
uniprot id: G8F3B3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9541:AGAP3
gene id: 9541:AGAP3
uniprot id: A0A2K5WI02
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9541:CNOT9
gene id: 9541:CNOT9
uniprot id: A0A2K5TLK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9541:SPARC
gene id: 9541:SPARC
uniprot id: A0A8J8XD95
uniprot id: G7P8R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

9541:CLUAP1
gene id: 9541:CLUAP1
uniprot id: A0A2K5W5E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9541:OGN
gene id: 9541:OGN
uniprot id: A0A8J8XM09
uniprot id: G7PSP7
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9541:CYP19A1
gene id: 9541:CYP19A1
uniprot id: A0A8J8YF18
uniprot id: Q95LY0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9541:SDHC
gene id: 9541:SDHC
uniprot id: A0A2K5VYJ1
uniprot id: A0A2K5VYL2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9541:TAFA3
gene id: 9541:TAFA3
uniprot id: A0A2K5UW67
names: Similarity
messages: Belongs to the TAFA family.

9541:CHMP5
gene id: 9541:CHMP5
uniprot id: A0A8J8XNK1
uniprot id: G7PS50
names: Similarity
messages: Belongs to the SNF7 family.

9541:TSPAN13
gene id: 9541:TSPAN13
uniprot id: A0A2K5WB15
names: Subcellular Location Annotation
messages: Membrane

9541:LIMS1
gene id: 9541:LIMS1
uniprot id: A0A8J8XB79
uniprot id: G7PMX1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9541:GBA2
gene id: 9541:GBA2
uniprot id: A0A8J8XAR2
uniprot id: G7PRZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

9541:RABAC1
gene id: 9541:RABAC1
uniprot id: A0A8J8Y7H0
uniprot id: G7PXQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9541:ASB14
gene id: 9541:ASB14
uniprot id: A0A2K5W3I0
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:CSTF3
gene id: 9541:CSTF3
uniprot id: A0A2K5UN07
names: Subcellular Location Annotation
messages: Nucleus

9541:CDH12
gene id: 9541:CDH12
uniprot id: A0A8J8YBU9
uniprot id: G7P7A5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9541:BBS5
gene id: 9541:BBS5
uniprot id: G7PKR7
uniprot id: Q4R649
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Cytoplasm
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10 (By similarity). Binds to phosphoinositides (By similarity). Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO (By similarity). Interacts with PKD1 (By similarity). Interacts with DLEC1 (By similarity).
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium basal body
messages: cilium membrane

9541:POU2F2
gene id: 9541:POU2F2
uniprot id: A0A2K5UQU5
uniprot id: A0A7N9D5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

9541:TBPL2
gene id: 9541:TBPL2
uniprot id: A0A2K5UUP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9541:ATP6V1G3
gene id: 9541:ATP6V1G3
uniprot id: G7NWH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9541:MC2R
gene id: 9541:MC2R
uniprot id: G7PWB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

9541:ALDH3A2
gene id: 9541:ALDH3A2
uniprot id: A0A2K5UZP3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:BVES
gene id: 9541:BVES
uniprot id: A0A8J8Y1C4
uniprot id: G7P446
names: Similarity
messages: Belongs to the popeye family.

9541:CTSH
gene id: 9541:CTSH
uniprot id: A0A2K5TRN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9541:SH3BGRL2
gene id: 9541:SH3BGRL2
uniprot id: A0A7N9CI10
names: Similarity
messages: Belongs to the SH3BGR family.

9541:ZDHHC17
gene id: 9541:ZDHHC17
uniprot id: A0A2K5VZT6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9541:CD74
gene id: 9541:CD74
uniprot id: A0A2K5U6J1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:DTYMK
gene id: 9541:DTYMK
uniprot id: A0A2K5TJ98
names: Similarity
messages: Belongs to the thymidylate kinase family.

9541:LOC102121807
gene id: 9541:LOC102121807
uniprot id: A0A2K5UGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:KIF16B
gene id: 9541:KIF16B
uniprot id: A0A2K5U453
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:IFT57
gene id: 9541:IFT57
uniprot id: A0A2K5X5U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9541:MB21D2
gene id: 9541:MB21D2
uniprot id: A0A2K5V0U2
names: Similarity
messages: Belongs to the mab-21 family.

9541:FABP3
gene id: 9541:FABP3
uniprot id: A0A8J8XTZ6
uniprot id: G7NWW7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:ACLY
gene id: 9541:ACLY
uniprot id: A0A2K5TWJ2
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9541:SYS1
gene id: 9541:SYS1
uniprot id: A0A2K5WIH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9541:SLC15A5
gene id: 9541:SLC15A5
uniprot id: A0A2K5X7S5
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

9541:BET1
gene id: 9541:BET1
uniprot id: A0A2K5UYH9
names: Subcellular Location Annotation
messages: Membrane

9541:NDUFS4
gene id: 9541:NDUFS4
uniprot id: A0A8J8XSU5
uniprot id: G7P7H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9541:SS18L2
gene id: 9541:SS18L2
uniprot id: A0A2K5WL77
names: Similarity
messages: Belongs to the SS18 family.

9541:TSHZ2
gene id: 9541:TSHZ2
uniprot id: A0A8J8XNW7
uniprot id: G7PFZ9
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

9541:GJA5
gene id: 9541:GJA5
uniprot id: A0A8J8YEV8
uniprot id: G7NTQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9541:TDRD5
gene id: 9541:TDRD5
uniprot id: A0A2K5VUJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.

9541:LOC102133588
gene id: 9541:LOC102133588
uniprot id: A0A7N9D0H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:GIMAP7
gene id: 9541:GIMAP7
uniprot id: G7P202
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9541:GLS2
gene id: 9541:GLS2
uniprot id: A0A2K5VU75
names: Similarity
messages: Belongs to the glutaminase family.

9541:CTNND1
gene id: 9541:CTNND1
uniprot id: A0A2K5UZM3
uniprot id: A0A2K5UZP1
uniprot id: G7PQ26
names: Similarity
messages: Belongs to the beta-catenin family.

9541:LMBR1L
gene id: 9541:LMBR1L
uniprot id: G7PHS1
uniprot id: Q4R7X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: Dimer (By similarity). Can also form higher oligomers (By similarity). Interacts with LCN1; this interaction mediates the endocytosis of LCN1 (By similarity). Interacts with UBAC2, FAF2, VCP, AMFR, ZNRF3, CTNNB1, LRP6, GSK3A, GSK3B, FZD6, DVL2 and RNF43 (By similarity). Interaction with LGB and SCGB1A1 is controversial (By similarity).
messages: Endoplasmic reticulum membrane
messages: Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (By similarity).

9541:CNRIP1
gene id: 9541:CNRIP1
uniprot id: A0A8J8Y8T3
uniprot id: G7PMC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9541:SLC7A2
gene id: 9541:SLC7A2
uniprot id: A0A2K5URE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9541:ZNF687
gene id: 9541:ZNF687
uniprot id: A0A2K5WG95
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:EBF1
gene id: 9541:EBF1
uniprot id: A0A2K5WH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9541:MIER3
gene id: 9541:MIER3
uniprot id: Q4R3R9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor.

9541:DNAH6
gene id: 9541:DNAH6
uniprot id: A0A2K5WM92
names: Similarity
messages: Belongs to the dynein heavy chain family.

9541:SLC30A8
gene id: 9541:SLC30A8
uniprot id: A0A2K5W7C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9541:ST3GAL2
gene id: 9541:ST3GAL2
uniprot id: A0A8J8XZS4
uniprot id: G7Q1L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:GNA13
gene id: 9541:GNA13
uniprot id: A0A2K5TVH0
uniprot id: A0A7N9CMF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9541:FXYD5
gene id: 9541:FXYD5
uniprot id: A0A8J8XKS7
uniprot id: G7PX84
names: Similarity
messages: Belongs to the FXYD family.

9541:C20H16orf87
gene id: 9541:C20H16orf87
uniprot id: A0A7N9CKG3
names: Similarity
messages: Belongs to the UPF0547 family.

9541:DGAT2
gene id: 9541:DGAT2
uniprot id: A0A2K5VCG5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:PTTG1
gene id: 9541:PTTG1
uniprot id: A0A2K5WQ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9541:BMP10
gene id: 9541:BMP10
uniprot id: A0A2K5WNW7
names: Similarity
messages: Belongs to the TGF-beta family.

9541:EMC1
gene id: 9541:EMC1
uniprot id: A0A2K5X7F9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:USB1
gene id: 9541:USB1
uniprot id: A0A2K5WCV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9541:POLR3G
gene id: 9541:POLR3G
uniprot id: A0A7N9DIF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9541:PSMA3
gene id: 9541:PSMA3
uniprot id: A0A2K5W6A0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9541:LIPA
gene id: 9541:LIPA
uniprot id: A0A2K5VBG9
uniprot id: Q4R4S5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol.
messages: Glycosylation is not essential for catalytic activity.
messages: Lysosome
messages: Monomer.

9541:HOPX
gene id: 9541:HOPX
uniprot id: I7GIM6
names: Subcellular Location Annotation
messages: Nucleus

9541:DPY30
gene id: 9541:DPY30
uniprot id: A0A2K5VRJ2
names: Similarity
messages: Belongs to the dpy-30 family.

9541:SFT2D1
gene id: 9541:SFT2D1
uniprot id: A0A8J8XND2
uniprot id: G7P487
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9541:CANX
gene id: 9541:CANX
uniprot id: A0A2K5UYZ9
names: Similarity
messages: Belongs to the calreticulin family.

9541:ZNF446
gene id: 9541:ZNF446
uniprot id: A0A2K5UI12
names: Subcellular Location Annotation
messages: Nucleus

9541:LOC107129555
gene id: 9541:LOC107129555
uniprot id: A0A2K5UG77
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9541:EPGN
gene id: 9541:EPGN
uniprot id: A0A8J8YCK1
uniprot id: G7P5K4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:SH3GL3
gene id: 9541:SH3GL3
uniprot id: A0A2K5WLY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9541:LOC102144964
gene id: 9541:LOC102144964
uniprot id: A0A8J8XVN4
uniprot id: G7NTR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:KCNJ12
gene id: 9541:KCNJ12
uniprot id: A0A7N9D225
uniprot id: A0A8J8XCB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

9541:VRK1
gene id: 9541:VRK1
uniprot id: A0A2K5UBQ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9541:INSL6
gene id: 9541:INSL6
uniprot id: A0A8J8YHS2
uniprot id: G7PSF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9541:MRPL15
gene id: 9541:MRPL15
uniprot id: A0A8J8XH12
uniprot id: G7PBU7
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9541:MMP1
gene id: 9541:MMP1
uniprot id: A0A8J8XTD3
uniprot id: G7PNK5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9541:GLRA2
gene id: 9541:GLRA2
uniprot id: A0A7N9IDE3
uniprot id: A0A8J8YHI7
uniprot id: G7Q291
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9541:EEF1G
gene id: 9541:EEF1G
uniprot id: Q4R7H5
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9541:PALMD
gene id: 9541:PALMD
uniprot id: A0A2K5U7C7
names: Similarity
messages: Belongs to the paralemmin family.

9541:RPN1
gene id: 9541:RPN1
uniprot id: Q4R4T0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with TMEM35A/NACHO (By similarity).
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: Melanosome
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

9541:NPTX1
gene id: 9541:NPTX1
uniprot id: A0A7N9ICP5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LOC102131960
gene id: 9541:LOC102131960
uniprot id: A0A2K5V1Z8
names: Similarity
messages: Belongs to the intermediate filament family.

9541:RPL31
gene id: 9541:RPL31
uniprot id: A0A8J8YQZ0
uniprot id: G7NZE1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9541:CAP1
gene id: 9541:CAP1
uniprot id: A0A2K5W2A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9541:LOC102115611
gene id: 9541:LOC102115611
uniprot id: A0A2K5X5H2
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9541:AAR2
gene id: 9541:AAR2
uniprot id: A0A7N9CY04
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9541:BANF2
gene id: 9541:BANF2
uniprot id: A0A2K5U180
names: Subcellular Location Annotation
messages: Nucleus

9541:HVCN1
gene id: 9541:HVCN1
uniprot id: A0A2K5VVC4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9541:SLC39A9
gene id: 9541:SLC39A9
uniprot id: A0A2K5URI7
uniprot id: A0A2K5URK1
uniprot id: A0A8J8XNJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

9541:SLC35D1
gene id: 9541:SLC35D1
uniprot id: A0A2K5UJZ6
names: Subcellular Location Annotation
messages: Membrane

9541:SCAMP1
gene id: 9541:SCAMP1
uniprot id: A0A2K5WJX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9541:PALS2
gene id: 9541:PALS2
uniprot id: Q4R814
names: Similarity
messages: Belongs to the MAGUK family.

9541:PSMG1
gene id: 9541:PSMG1
uniprot id: A0A2K5UTC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9541:LOC102124806
gene id: 9541:LOC102124806
uniprot id: A0A2K5V886
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

9541:BCLAF3
gene id: 9541:BCLAF3
uniprot id: A0A8J8XDS4
uniprot id: G7Q2C2
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9541:TNP1
gene id: 9541:TNP1
uniprot id: G7PLE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Chromosome
messages: Nucleus

9541:FLT1
gene id: 9541:FLT1
uniprot id: A0A2K5VAF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9541:TBX22
gene id: 9541:TBX22
uniprot id: A0A8J8XP92
uniprot id: G7Q341
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9541:LOC102130791
gene id: 9541:LOC102130791
uniprot id: A0A2K5UP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:PADI6
gene id: 9541:PADI6
uniprot id: A0A8J8XPE7
uniprot id: G7NUR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9541:MICOS13
gene id: 9541:MICOS13
uniprot id: G7PYT4
uniprot id: Q2ACH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, MICOS13/MIC13, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9541:PNMA2
gene id: 9541:PNMA2
uniprot id: Q9GMU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNMA family.
messages: nucleolus

9541:CHST10
gene id: 9541:CHST10
uniprot id: A0A8J8XHX9
uniprot id: G7PMT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9541:TMEM178B
gene id: 9541:TMEM178B
uniprot id: A0A2K5VJF5
names: Similarity
messages: Belongs to the TMEM178 family.

9541:SLC2A11
gene id: 9541:SLC2A11
uniprot id: A0A2K5VQK6
names: Subcellular Location Annotation
messages: Cell membrane

9541:APEX1
gene id: 9541:APEX1
uniprot id: G8F5P8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9541:VPS52
gene id: 9541:VPS52
uniprot id: A0A7N9D492
names: Similarity
messages: Belongs to the VPS52 family.

9541:FAM174B
gene id: 9541:FAM174B
uniprot id: A0A2K5U0X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9541:TMEM33
gene id: 9541:TMEM33
uniprot id: A0A8J8XUW8
uniprot id: G7P5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9541:LSM5
gene id: 9541:LSM5
uniprot id: A0A7N9D8I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9541:SLC17A5
gene id: 9541:SLC17A5
uniprot id: A0A2K5VPS7
names: Subcellular Location Annotation
messages: Membrane

9541:SF3B5
gene id: 9541:SF3B5
uniprot id: A0A2K5UMW7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9541:HOXB1
gene id: 9541:HOXB1
uniprot id: A0A7N9D9U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9541:UBA3
gene id: 9541:UBA3
uniprot id: A0A2K5WLF3
uniprot id: A0A2K5WLL1
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9541:PROK2
gene id: 9541:PROK2
uniprot id: A0A2K5WC32
uniprot id: A0A2K5WC77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9541:EFNB1
gene id: 9541:EFNB1
uniprot id: A0A7N9CAH0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:EFNA5
gene id: 9541:EFNA5
uniprot id: A0A2K5X7N8
uniprot id: A0A8J8XVD8
uniprot id: G7P813
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:VPS53
gene id: 9541:VPS53
uniprot id: A0A2K5U0Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9541:PSMA5
gene id: 9541:PSMA5
uniprot id: A0A8J8XD69
uniprot id: G7NV55
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9541:TRIM9
gene id: 9541:TRIM9
uniprot id: A0A2K5V3V0
uniprot id: A0A7N9IEF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

9541:FOXR1
gene id: 9541:FOXR1
uniprot id: A0A2K5WV77
names: Subcellular Location Annotation
messages: Nucleus

9541:FGR
gene id: 9541:FGR
uniprot id: A0A2K5WJL3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9541:FAM13A
gene id: 9541:FAM13A
uniprot id: A0A2K5V740
uniprot id: A0A2K5V751
uniprot id: A0A2K5V776
names: Similarity
messages: Belongs to the FAM13 family.

9541:PELO
gene id: 9541:PELO
uniprot id: A0A2K5X8U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
messages: Cytoplasm

9541:RETREG1
gene id: 9541:RETREG1
uniprot id: A0A2K5UGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:NREP
gene id: 9541:NREP
uniprot id: Q4R541
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction. Interacts with FLNA.
messages: May have roles in neural function and cellular differentiation. Ectopic expression promotes axonal regeneration, induces differentiation of fibroblast into myofibroblast, induces myofibroblast ameboid migration, augments motility of gliomas, and increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation.
messages: Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.

9541:PLPBP
gene id: 9541:PLPBP
uniprot id: G7PD65
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9541:PPP2R5B
gene id: 9541:PPP2R5B
uniprot id: A0A2K5VWY4
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9541:DPP4
gene id: 9541:DPP4
uniprot id: A0A2K5VXJ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9541:KBTBD8
gene id: 9541:KBTBD8
uniprot id: A0A2K5WA77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9541:CDR2
gene id: 9541:CDR2
uniprot id: A0A2K5WHW2
names: Similarity
messages: Belongs to the CDR2 family.

9541:RPP14
gene id: 9541:RPP14
uniprot id: A0A2K5WD56
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9541:HSD3B7
gene id: 9541:HSD3B7
uniprot id: A0A2K5UGL1
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9541:GADD45G
gene id: 9541:GADD45G
uniprot id: A0A2K5X2X3
names: Similarity
messages: Belongs to the GADD45 family.

9541:GOT1
gene id: 9541:GOT1
uniprot id: A0A805Q1X1
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9541:GCG
gene id: 9541:GCG
uniprot id: A0A2K5WWG8
names: Similarity
messages: Belongs to the glucagon family.

9541:CCDC65
gene id: 9541:CCDC65
uniprot id: A0A2K5X8W7
names: Subcellular Location Annotation
messages: flagellum axoneme

9541:SLC41A2
gene id: 9541:SLC41A2
uniprot id: A0A2K5TL38
uniprot id: Q4R335
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Acts as a plasma-membrane magnesium transporter. Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+).
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Membrane

9541:GFRA1
gene id: 9541:GFRA1
uniprot id: A0A2K5TWP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9541:DDX49
gene id: 9541:DDX49
uniprot id: A0A2K5VP37
names: Similarity
messages: Belongs to the DEAD box helicase family.

9541:INHA
gene id: 9541:INHA
uniprot id: A0A2K5U0P0
uniprot id: G7PK56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9541:AGXT
gene id: 9541:AGXT
uniprot id: A0A2K5VWZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Peroxisome

9541:AZGP1
gene id: 9541:AZGP1
uniprot id: A0A2K5TU41
names: Similarity
messages: Belongs to the MHC class I family.

9541:ARHGAP26
gene id: 9541:ARHGAP26
uniprot id: A0A7N9CJZ9
uniprot id: A0A7N9IDB1
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9541:MID1
gene id: 9541:MID1
uniprot id: A0A8J8YI77
uniprot id: G7Q274
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

9541:OCIAD1
gene id: 9541:OCIAD1
uniprot id: A0A2K5VJ58
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9541:ARPC2
gene id: 9541:ARPC2
uniprot id: A0A2K5UPF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9541:BLOC1S6
gene id: 9541:BLOC1S6
uniprot id: A0A2K5U4D3
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9541:FUNDC1
gene id: 9541:FUNDC1
uniprot id: A0A2K5VGS0
uniprot id: G8F3H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9541:C18H18orf21
gene id: 9541:C18H18orf21
uniprot id: A0A2K5WZR5
uniprot id: A0A2K5X0B3
names: Similarity
messages: Belongs to the UPF0711 family.

9541:TMEM208
gene id: 9541:TMEM208
uniprot id: A0A2K5W1G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9541:ZNF75D
gene id: 9541:ZNF75D
uniprot id: A0A2K5X9F7
names: Subcellular Location Annotation
messages: Nucleus

9541:TAS2R4
gene id: 9541:TAS2R4
uniprot id: A0A7N9IHD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: cilium membrane

9541:LOC102135548
gene id: 9541:LOC102135548
uniprot id: A0A7N9C9R4
names: Subcellular Location Annotation
messages: Cytoplasm

9541:DDAH1
gene id: 9541:DDAH1
uniprot id: A0A2K5TPG8
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9541:XCL1
gene id: 9541:XCL1
uniprot id: A0A2K5WQG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9541:ARL4D
gene id: 9541:ARL4D
uniprot id: A0A2K5UN88
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9541:S100A16
gene id: 9541:S100A16
uniprot id: A0A8J8XDV7
uniprot id: G7NUG9
names: Similarity
messages: Belongs to the S-100 family.

9541:PGAP1
gene id: 9541:PGAP1
uniprot id: A0A2K5UNM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9541:C6H5orf22
gene id: 9541:C6H5orf22
uniprot id: A0A2K5UT40
names: Similarity
messages: Belongs to the UPF0489 family.

9541:CPNE9
gene id: 9541:CPNE9
uniprot id: A0A2K5VBD9
names: Similarity
messages: Belongs to the copine family.

9541:NPPA
gene id: 9541:NPPA
uniprot id: A0A2K5VBM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9541:CARTPT
gene id: 9541:CARTPT
uniprot id: A0A8J8YQB8
uniprot id: G7P7P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9541:LYRM7
gene id: 9541:LYRM7
uniprot id: A0A2K5V8X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9541:SLC16A9
gene id: 9541:SLC16A9
uniprot id: A0A8J8YS42
uniprot id: G7PDF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane

9541:PKIG
gene id: 9541:PKIG
uniprot id: A0A8J8XTY9
uniprot id: G7PGB4
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9541:PTGS1
gene id: 9541:PTGS1
uniprot id: A0A2K5WTA5
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ELSPBP1
gene id: 9541:ELSPBP1
uniprot id: A0A2K5UBA0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:AICDA
gene id: 9541:AICDA
uniprot id: A0A2K5WJH5
names: Subcellular Location Annotation
messages: Cytoplasm

9541:TSR2
gene id: 9541:TSR2
uniprot id: A0A7N9CWW3
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

9541:SNX25
gene id: 9541:SNX25
uniprot id: A0A2K5WIU5
names: Similarity
messages: Belongs to the sorting nexin family.

9541:GPR146
gene id: 9541:GPR146
uniprot id: Q8HXF4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9541:IGF1R
gene id: 9541:IGF1R
uniprot id: A0A2K5W796
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9541:SLC16A6
gene id: 9541:SLC16A6
uniprot id: A0A8J8XB19
uniprot id: G7PV86
names: Subcellular Location Annotation
messages: Membrane

9541:MBTPS2
gene id: 9541:MBTPS2
uniprot id: A0A7N9D5H2
uniprot id: A0A8J8XRU4
uniprot id: G7Q2C9
names: Similarity
messages: Belongs to the peptidase M50A family.

9541:EIF3E
gene id: 9541:EIF3E
uniprot id: Q4R6G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2 (By similarity). Interacts with IFIT1 and IFIT2 (By similarity). Interacts with BZW2/5MP1 (By similarity).
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: PML body

9541:EGFR
gene id: 9541:EGFR
uniprot id: A0A2K5WK39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9541:SLC16A4
gene id: 9541:SLC16A4
uniprot id: A0A2K5WWK4
uniprot id: A0A2K5WWT1
names: Subcellular Location Annotation
messages: Membrane

9541:GUCY1A1
gene id: 9541:GUCY1A1
uniprot id: A0A2K5UZU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9541:SIX1
gene id: 9541:SIX1
uniprot id: A0A2K5V3Q4
names: Subcellular Location Annotation
messages: Nucleus

9541:GPER1
gene id: 9541:GPER1
uniprot id: A0A2K5WYF2
uniprot id: A0A8J8YA21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:MDH1B
gene id: 9541:MDH1B
uniprot id: A0A2K5VAL2
uniprot id: A0A7N9CNW0
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9541:AK2
gene id: 9541:AK2
uniprot id: A0A2K5WQR9
uniprot id: A0A7N9CVL8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9541:LOC102121032
gene id: 9541:LOC102121032
uniprot id: G7PRS7
names: Subcellular Location Annotation
messages: Membrane

9541:ACSF2
gene id: 9541:ACSF2
uniprot id: A0A2K5VZB6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9541:RNF152
gene id: 9541:RNF152
uniprot id: A0A8J8YFA8
uniprot id: G7PWW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

9541:MCHR2
gene id: 9541:MCHR2
uniprot id: A0A2K5X035
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CCSER1
gene id: 9541:CCSER1
uniprot id: A0A2K5V547
names: Similarity
messages: Belongs to the CCSER family.

9541:LDLRAD3
gene id: 9541:LDLRAD3
uniprot id: A0A7N9C7V6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:EDC3
gene id: 9541:EDC3
uniprot id: A0A2K5VDI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9541:SMIM22
gene id: 9541:SMIM22
uniprot id: A0A8J8YC88
uniprot id: G7Q0F0
names: Subcellular Location Annotation
messages: Membrane

9541:PBX3
gene id: 9541:PBX3
uniprot id: A0A2K5UKT8
uniprot id: A0A2K5UKW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9541:WDR83OS
gene id: 9541:WDR83OS
uniprot id: A0A2K5X8Q3
names: Similarity
messages: Belongs to the Asterix family.

9541:RNF112
gene id: 9541:RNF112
uniprot id: A0A2K5U3J2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9541:KIF5B
gene id: 9541:KIF5B
uniprot id: A0A8J8XFK3
uniprot id: G7PEP7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9541:CHMP4C
gene id: 9541:CHMP4C
uniprot id: A0A2K5UK16
names: Similarity
messages: Belongs to the SNF7 family.

9541:LOC102138312
gene id: 9541:LOC102138312
uniprot id: A0A8J8XBQ0
uniprot id: G7PRZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9541:DTX3
gene id: 9541:DTX3
uniprot id: A0A2K5TM11
uniprot id: A0A2K5TM17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9541:CLPS
gene id: 9541:CLPS
uniprot id: G7P3A9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9541:MTOR
gene id: 9541:MTOR
uniprot id: A0A2K5WYX7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9541:TMEM50B
gene id: 9541:TMEM50B
uniprot id: G8F4V1
uniprot id: Q4R670
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9541:CAMK2D
gene id: 9541:CAMK2D
uniprot id: G7P650
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9541:INTS9
gene id: 9541:INTS9
uniprot id: A0A2K5VH01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

9541:LOC102146578
gene id: 9541:LOC102146578
uniprot id: A0A2K5UX20
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9541:TICAM1
gene id: 9541:TICAM1
uniprot id: B3Y696
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.
messages: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
messages: Mitochondrion
messages: The N-terminal region is essential for activation of the IFNB promoter activity.
messages: autophagosome
messages: cytosol

9541:CACNG2
gene id: 9541:CACNG2
uniprot id: A0A2K5WFY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

9541:HDAC11
gene id: 9541:HDAC11
uniprot id: Q9GKU5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family.
messages: Interacts with HDAC6.
messages: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).

9541:ITGB8
gene id: 9541:ITGB8
uniprot id: A0A8J8YB37
uniprot id: G7P0S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9541:MED23
gene id: 9541:MED23
uniprot id: A0A2K5UEW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

9541:EIF2B4
gene id: 9541:EIF2B4
uniprot id: A0A7N9CP23
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9541:CRABP2
gene id: 9541:CRABP2
uniprot id: A0A8J8XJ89
uniprot id: G7NV96
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:CENPN
gene id: 9541:CENPN
uniprot id: A0A8J8XL27
uniprot id: G7PZT4
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9541:PPP2R5E
gene id: 9541:PPP2R5E
uniprot id: A0A2K5TKQ9
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9541:DES
gene id: 9541:DES
uniprot id: B3Y602
names: Similarity
messages: Belongs to the intermediate filament family.

9541:SPCS1
gene id: 9541:SPCS1
uniprot id: A0A2K5TLE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9541:POPDC3
gene id: 9541:POPDC3
uniprot id: A0A8J8Y1R0
uniprot id: G7P447
names: Similarity
messages: Belongs to the popeye family.

9541:WFIKKN2
gene id: 9541:WFIKKN2
uniprot id: A0A2K5VVF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WFIKKN family.
messages: Secreted

9541:DDR1
gene id: 9541:DDR1
uniprot id: A0A2K5V739
names: Subcellular Location Annotation
messages: Membrane

9541:PPIC
gene id: 9541:PPIC
uniprot id: A0A2K5V6K3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9541:LOC102128376
gene id: 9541:LOC102128376
uniprot id: A0A2K5VWQ5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 2 Zn(2+) ions per subunit.

9541:KNG1
gene id: 9541:KNG1
uniprot id: A0A2K5WUB5
names: Subcellular Location Annotation
messages: extracellular space

9541:ST8SIA1
gene id: 9541:ST8SIA1
uniprot id: A0A2K5W1P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9541:MDH1
gene id: 9541:MDH1
uniprot id: I7GHA1
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9541:FOLH1B
gene id: 9541:FOLH1B
uniprot id: A0A2K5VNZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9541:RPGRIP1L
gene id: 9541:RPGRIP1L
uniprot id: A0A2K5VF28
names: Similarity
messages: Belongs to the RPGRIP1 family.

9541:ATP7A
gene id: 9541:ATP7A
uniprot id: A0A2K5X0T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9541:LOC102137780
gene id: 9541:LOC102137780
uniprot id: A0A2K5VHL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9541:LOC102143686
gene id: 9541:LOC102143686
uniprot id: A0A7N9CJD3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9541:STX17
gene id: 9541:STX17
uniprot id: A0A8J8XDT2
uniprot id: I7GBM2
names: Similarity
messages: Belongs to the syntaxin family.

9541:CHRM2
gene id: 9541:CHRM2
uniprot id: A0A8J8XET9
uniprot id: G7P0W8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9541:CCL5
gene id: 9541:CCL5
uniprot id: G7PU47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9541:LOC102118955
gene id: 9541:LOC102118955
uniprot id: A0A2K5WVY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

9541:RAP1B
gene id: 9541:RAP1B
uniprot id: Q4R9D4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell junction
messages: Cell membrane
messages: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).
messages: Heterodimer with RAP1GAP (By similarity). Interacts with EPAC2 (By similarity). Interacts with SGSM1 (By similarity). Interacts with SGSM2 (By similarity). Interacts with SGSM3 (By similarity). Interacts with KRIT1 (By similarity). Interacts with RAP1GDS1 (By similarity).
messages: cytosol

9541:KEG98 p10
gene id: 9541:KEG98_p10
uniprot id: C3W4Y8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9541:ZSCAN20
gene id: 9541:ZSCAN20
uniprot id: A0A2K5TS95
uniprot id: A0A2K5TSB1
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9541:SEPTIN4
gene id: 9541:SEPTIN4
uniprot id: A0A2K5WM76
uniprot id: A0A2K5WN04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9541:NPY2R
gene id: 9541:NPY2R
uniprot id: A0A2K5UGU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CCNI
gene id: 9541:CCNI
uniprot id: A0A7N9CZQ9
names: Similarity
messages: Belongs to the cyclin family.

9541:HYAL1
gene id: 9541:HYAL1
uniprot id: A0A2K5W786
uniprot id: G7NXS8
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9541:BAAT
gene id: 9541:BAAT
uniprot id: A0A2K5U9Z4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9541:BOLA1
gene id: 9541:BOLA1
uniprot id: G7NTR8
names: Similarity
messages: Belongs to the BolA/IbaG family.

9541:CPS1
gene id: 9541:CPS1
uniprot id: A0A2K5VK62
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:ANKS1B
gene id: 9541:ANKS1B
uniprot id: I7G3R7
uniprot id: Q4R4X1
names: Subcellular Location Annotation
messages: Cytoplasm

9541:PSMD3
gene id: 9541:PSMD3
uniprot id: A0A2K5TLI1
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9541:GNMT
gene id: 9541:GNMT
uniprot id: A0A2K5VR98
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9541:TNFRSF21
gene id: 9541:TNFRSF21
uniprot id: A0A2K5VIJ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9541:LYRM4
gene id: 9541:LYRM4
uniprot id: A0A7N9CNF5
names: Similarity
messages: Belongs to the complex I LYR family.

9541:S1PR1
gene id: 9541:S1PR1
uniprot id: A0A7N9I9K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9541:CNOT10
gene id: 9541:CNOT10
uniprot id: A0A2K5WX48
uniprot id: A0A8J8XNM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9541:PCYOX1
gene id: 9541:PCYOX1
uniprot id: A0A2K5WQJ3
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9541:HSD17B3
gene id: 9541:HSD17B3
uniprot id: A0A2K5TM58
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9541:LOC102123072
gene id: 9541:LOC102123072
uniprot id: A0A2K5UJS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9541:SLC4A7
gene id: 9541:SLC4A7
uniprot id: A0A2K5UB14
uniprot id: A0A2K5UB60
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9541:TOMM40L
gene id: 9541:TOMM40L
uniprot id: A0A8J8XG92
uniprot id: I7GJP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9541:CBLIF
gene id: 9541:CBLIF
uniprot id: A0A2K5WX57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9541:ASB15
gene id: 9541:ASB15
uniprot id: A0A2K5TQ56
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9541:CRABP1
gene id: 9541:CRABP1
uniprot id: A0A7N9D888
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9541:PRKACG
gene id: 9541:PRKACG
uniprot id: A0A2K5UPW7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9541:CMKLR1
gene id: 9541:CMKLR1
uniprot id: A0A2K5UG47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9541:ALDH8A1
gene id: 9541:ALDH8A1
uniprot id: A0A2K5TPT0
uniprot id: A0A2K5TPT1
uniprot id: A0A2K5TPV0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9541:SDHAF2
gene id: 9541:SDHAF2
uniprot id: A0A2K5WLA7
uniprot id: Q9GMX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9541:NUBP1
gene id: 9541:NUBP1
uniprot id: A0A2K5X7I4
uniprot id: A0A2K5X7Y1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9541:PSMA7
gene id: 9541:PSMA7
uniprot id: A0A2K5X9B7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9541:TAS2R3
gene id: 9541:TAS2R3
uniprot id: A0A7N9DBR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9541:PHYHIPL
gene id: 9541:PHYHIPL
uniprot id: A0A2K5WMU6
names: Similarity
messages: Belongs to the PHYHIP family.

9541:TOB2
gene id: 9541:TOB2
uniprot id: A0A8J8XZH4
uniprot id: G7PFN2
names: Similarity
messages: Belongs to the BTG family.

9541:LOC102130747
gene id: 9541:LOC102130747
uniprot id: A0A8J8XYD0
uniprot id: G7Q275
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9541:NT5C3B
gene id: 9541:NT5C3B
uniprot id: A0A2K5U762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9541:CD151
gene id: 9541:CD151
uniprot id: A0A2K5WB08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:LDB2
gene id: 9541:LDB2
uniprot id: A0A8J8Y9Y1
uniprot id: Q4R522
names: Similarity
messages: Belongs to the LDB family.

9541:NME5
gene id: 9541:NME5
uniprot id: A0A2K5WL60
names: Similarity
messages: Belongs to the NDK family.

9541:MSX2
gene id: 9541:MSX2
uniprot id: A0A7N9D9E7
names: Subcellular Location Annotation
messages: Nucleus

9541:FAM210A
gene id: 9541:FAM210A
uniprot id: A0A7N9CLE0
names: Similarity
messages: Belongs to the FAM210 family.

9541:EFNA1
gene id: 9541:EFNA1
uniprot id: A0A2K5WTZ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:NRDC
gene id: 9541:NRDC
uniprot id: A0A7N9DC69
names: Similarity
messages: Belongs to the peptidase M16 family.

9541:UROS
gene id: 9541:UROS
uniprot id: A0A2K5VG84
uniprot id: A0A7N9C9Y7
uniprot id: A0A7N9D060
uniprot id: A0A7N9D6H7
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9541:AGBL3
gene id: 9541:AGBL3
uniprot id: A0A2K5UME5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9541:POLR3F
gene id: 9541:POLR3F
uniprot id: A0A2K5TYI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9541:TSPAN18
gene id: 9541:TSPAN18
uniprot id: A0A7N9C837
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9541:GLRB
gene id: 9541:GLRB
uniprot id: A0A8J8XHE4
uniprot id: G7P6H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9541:STEEP1
gene id: 9541:STEEP1
uniprot id: A0A8J8XSK9
uniprot id: G7Q3K3
names: Similarity
messages: Belongs to the STEEP1 family.

9541:CHAF1B
gene id: 9541:CHAF1B
uniprot id: A0A2K5TRB7
uniprot id: A0A8J8Y6S7
uniprot id: G7P111
names: Subcellular Location Annotation
messages: Nucleus

9541:CA5B
gene id: 9541:CA5B
uniprot id: A0A2K5WNP4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9541:GTF2E2
gene id: 9541:GTF2E2
uniprot id: A0A8J8XTQ5
uniprot id: G7PD55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9541:DLX5
gene id: 9541:DLX5
uniprot id: A0A8J8XWF5
uniprot id: G7P1B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9541:SELL
gene id: 9541:SELL
uniprot id: A0A7N9DE02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:MCCC2
gene id: 9541:MCCC2
uniprot id: A0A2K5U7P9
names: Similarity
messages: Belongs to the AccD/PCCB family.

9541:MMD
gene id: 9541:MMD
uniprot id: A0A8J8XAH4
uniprot id: G7PUD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9541:TMOD4
gene id: 9541:TMOD4
uniprot id: A0A2K5WG56
names: Subcellular Location Annotation
messages: cytoskeleton

9541:LOC102118091
gene id: 9541:LOC102118091
uniprot id: A0A2K5UJK7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9541:ZNF277
gene id: 9541:ZNF277
uniprot id: A0A2K5U610
names: Similarity
messages: Belongs to the ZNF277 family.

9541:CFL1
gene id: 9541:CFL1
uniprot id: Q4R5C0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin-binding proteins ADF family.
messages: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (By similarity). Important for normal progress through mitosis and normal cytokinesis (By similarity). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
messages: Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (By similarity). It is a major component of intranuclear and cytoplasmic actin rods (By similarity). Interacts with the subcortical maternal complex (SCMC) via interaction with TLE6 and NLRP5 (By similarity). Interacts with C9orf72 (By similarity).
messages: Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2 (By similarity).
messages: Nucleus matrix
messages: axon
messages: cytoskeleton
messages: growth cone
messages: lamellipodium
messages: lamellipodium membrane
messages: ruffle membrane

9541:TM7SF2
gene id: 9541:TM7SF2
uniprot id: I7GPM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9541:MUSK
gene id: 9541:MUSK
uniprot id: A0A2K5USF6
uniprot id: A0A2K5USG2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9541:UCHL1
gene id: 9541:UCHL1
uniprot id: I7GJN1
names: Similarity
messages: Belongs to the peptidase C12 family.

9541:CALHM6
gene id: 9541:CALHM6
uniprot id: A0A8J8Y2T0
uniprot id: G7P3L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9541:SLC16A13
gene id: 9541:SLC16A13
uniprot id: A0A2K5UEG7
names: Subcellular Location Annotation
messages: Membrane

9541:IL1R1
gene id: 9541:IL1R1
uniprot id: A0A7N9CMI5
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9541:SULF2
gene id: 9541:SULF2
uniprot id: A0A2K5VBR2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9541:AVL9
gene id: 9541:AVL9
uniprot id: A0A2K5USR4
names: Subcellular Location Annotation
messages: Recycling endosome

9541:TEAD2
gene id: 9541:TEAD2
uniprot id: A0A2K5V9V8
uniprot id: A0A2K5V9X5
names: Subcellular Location Annotation
messages: Nucleus

9541:CLDN22
gene id: 9541:CLDN22
uniprot id: A0A2K5UF63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9541:MMACHC
gene id: 9541:MMACHC
uniprot id: A0A2K5U3Q3
names: Similarity
messages: Belongs to the MMACHC family.

9541:EML6
gene id: 9541:EML6
uniprot id: A0A2K5VMM7
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

9541:RPL38
gene id: 9541:RPL38
uniprot id: A0A8J8XP23
uniprot id: G7PVB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9541:ALPL
gene id: 9541:ALPL
uniprot id: A0A2K5U1L9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9541:PPOX
gene id: 9541:PPOX
uniprot id: A0A8J8XJT1
uniprot id: G7NXA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9541:LBR
gene id: 9541:LBR
uniprot id: A0A2K5TKM6
uniprot id: A0A8J8XAI0
uniprot id: G7NTV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9541:DCC
gene id: 9541:DCC
uniprot id: A0A2K5V8I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9541:DOK4
gene id: 9541:DOK4
uniprot id: A0A8J8XQP8
uniprot id: G7Q182
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9541:PIWIL3
gene id: 9541:PIWIL3
uniprot id: G7PHF0
names: Similarity
messages: Belongs to the argonaute family.