9483:TSEN54
gene id: 9483:TSEN54
uniprot id: F7INL6
names: Similarity
messages: Belongs to the SEN54 family.

9483:UNC5D
gene id: 9483:UNC5D
uniprot id: A0A2R8MK76
uniprot id: A0A8I3WKF9
uniprot id: F7IHE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9483:LOC100411313
gene id: 9483:LOC100411313
uniprot id: U3CJ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9483:KRT18
gene id: 9483:KRT18
uniprot id: F6RWB1
names: Similarity
messages: Belongs to the intermediate filament family.

9483:OLFR600
gene id: 9483:OLFR600
uniprot id: B0VXA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PCNA
gene id: 9483:PCNA
uniprot id: U3CWY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9483:GJA8
gene id: 9483:GJA8
uniprot id: A0A654IC84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:LEO1
gene id: 9483:LEO1
uniprot id: F7CCM6
names: Similarity
messages: Belongs to the LEO1 family.

9483:EDNRA
gene id: 9483:EDNRA
uniprot id: F6YN68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9483:VTI1B
gene id: 9483:VTI1B
uniprot id: F7AQT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9483:MSTN
gene id: 9483:MSTN
uniprot id: F6Y9D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted

9483:SRP14
gene id: 9483:SRP14
uniprot id: A0A8I3XD27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

9483:CSRNP2
gene id: 9483:CSRNP2
uniprot id: F7EDZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9483:CD244
gene id: 9483:CD244
uniprot id: U3DBJ2
names: Subcellular Location Annotation
messages: Membrane

9483:LOC100403816
gene id: 9483:LOC100403816
uniprot id: F7IA43
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:IL17B
gene id: 9483:IL17B
uniprot id: A0A5F4WDJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9483:LOC100895074
gene id: 9483:LOC100895074
uniprot id: A0A8I3WPI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:TAF15
gene id: 9483:TAF15
uniprot id: F7GUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9483:SLC9A2
gene id: 9483:SLC9A2
uniprot id: F6SCS6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9483:LGI2
gene id: 9483:LGI2
uniprot id: A0A8J8YCU6
names: Subcellular Location Annotation
messages: Secreted

9483:PPP1R15B
gene id: 9483:PPP1R15B
uniprot id: F7IF39
names: Similarity
messages: Belongs to the PPP1R15 family.

9483:TMEM168
gene id: 9483:TMEM168
uniprot id: U3C6I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane
messages: Nucleus membrane

9483:ADRA1A
gene id: 9483:ADRA1A
uniprot id: A0A8I3X918
uniprot id: A0A8I3XFH9
uniprot id: F6QIG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9483:NSMCE4A
gene id: 9483:NSMCE4A
uniprot id: F7HV64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

9483:EDC3
gene id: 9483:EDC3
uniprot id: F7ERK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9483:ARL4C
gene id: 9483:ARL4C
uniprot id: U3FEV8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9483:TGFB2
gene id: 9483:TGFB2
uniprot id: F7G0A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9483:FAM131A
gene id: 9483:FAM131A
uniprot id: F7H4H4
names: Similarity
messages: Belongs to the FAM131 family.

9483:TOR1AIP1
gene id: 9483:TOR1AIP1
uniprot id: A0A5F4VZ85
uniprot id: U3CW96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9483:IL1B
gene id: 9483:IL1B
uniprot id: F6RH14
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9483:SLC35B4
gene id: 9483:SLC35B4
uniprot id: U3D595
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9483:TRIM26
gene id: 9483:TRIM26
uniprot id: F7IQQ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:TOP2B
gene id: 9483:TOP2B
uniprot id: U3BD56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9483:ARPIN
gene id: 9483:ARPIN
uniprot id: U3FN27
names: Similarity
messages: Belongs to the Arpin family.

9483:ALKBH2
gene id: 9483:ALKBH2
uniprot id: F7GQA0
names: Similarity
messages: Belongs to the alkB family.

9483:FURIN
gene id: 9483:FURIN
uniprot id: U3FS81
names: Similarity
messages: Belongs to the peptidase S8 family.

9483:APLP2
gene id: 9483:APLP2
uniprot id: F7D967
uniprot id: F7I340
uniprot id: U3FVA2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:TFDP2
gene id: 9483:TFDP2
uniprot id: A0A8I3WXA2
uniprot id: U3FFN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9483:RPAIN
gene id: 9483:RPAIN
uniprot id: A0A2R8M5T4
uniprot id: F7GVG1
uniprot id: U3ETR1
names: Subcellular Location Annotation
messages: Nucleus

9483:SESN2
gene id: 9483:SESN2
uniprot id: A0A2R8P1V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9483:PDIA3
gene id: 9483:PDIA3
uniprot id: B0KWG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9483:DEFB128
gene id: 9483:DEFB128
uniprot id: A0A8I3W5R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:FABP7
gene id: 9483:FABP7
uniprot id: U3EM14
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:C14H2orf68
gene id: 9483:C14H2orf68
uniprot id: F7DPH6
names: Similarity
messages: Belongs to the UPF0561 family.

9483:NSMCE2
gene id: 9483:NSMCE2
uniprot id: F7HZF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

9483:MAOB
gene id: 9483:MAOB
uniprot id: F7IRJ7
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9483:AGTRAP
gene id: 9483:AGTRAP
uniprot id: U3CLC5
uniprot id: U3FGS3
names: Subcellular Location Annotation
messages: Membrane

9483:TLR9
gene id: 9483:TLR9
uniprot id: F7HZH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9483:GCLM
gene id: 9483:GCLM
uniprot id: Q2I825
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

9483:LOC100400759
gene id: 9483:LOC100400759
uniprot id: A0A2R8MD14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9483:LOC100393317
gene id: 9483:LOC100393317
uniprot id: F7CCF9
names: Similarity
messages: Belongs to the CLCR family.

9483:OLFR561
gene id: 9483:OLFR561
uniprot id: B0VX91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CBFB
gene id: 9483:CBFB
uniprot id: F7BRE0
uniprot id: U3FT28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

9483:FUCA2
gene id: 9483:FUCA2
uniprot id: A0A8I3WDS3
uniprot id: A0A8I3WY39
uniprot id: A0A8I3XDK9
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9483:PGLYRP1
gene id: 9483:PGLYRP1
uniprot id: F6V9G7
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9483:SERPINA11
gene id: 9483:SERPINA11
uniprot id: F7I7B1
names: Similarity
messages: Belongs to the serpin family.

9483:RPL28
gene id: 9483:RPL28
uniprot id: F6VGW5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

9483:IL1R1
gene id: 9483:IL1R1
uniprot id: U3DT41
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9483:UBLCP1
gene id: 9483:UBLCP1
uniprot id: U3FI55
names: Subcellular Location Annotation
messages: Nucleus

9483:MEP1B
gene id: 9483:MEP1B
uniprot id: F7I1Y3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CYP4F11
gene id: 9483:CYP4F11
uniprot id: A0A1P8NQK8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:PRPF4
gene id: 9483:PRPF4
uniprot id: U3C117
names: Subcellular Location Annotation
messages: Nucleus speckle

9483:TIGD4
gene id: 9483:TIGD4
uniprot id: F7HQK9
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100401074
gene id: 9483:LOC100401074
uniprot id: A0A5F4VXW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:PITHD1
gene id: 9483:PITHD1
uniprot id: F7I905
names: Similarity
messages: Belongs to the PITHD1 family.

9483:AMPD3
gene id: 9483:AMPD3
uniprot id: F7H1G4
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9483:AQP11
gene id: 9483:AQP11
uniprot id: A0A2R8MJH3
uniprot id: A0A2R8MP89
uniprot id: F7ELM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

9483:IZUMO2
gene id: 9483:IZUMO2
uniprot id: F6Y8E8
names: Similarity
messages: Belongs to the Izumo family.

9483:SLC39A14
gene id: 9483:SLC39A14
uniprot id: A0A8I3WME3
names: Subcellular Location Annotation
messages: Membrane

9483:MYBL1
gene id: 9483:MYBL1
uniprot id: F7HNE8
uniprot id: F7ISE4
names: Subcellular Location Annotation
messages: Nucleus

9483:PSMD7
gene id: 9483:PSMD7
uniprot id: F7E772
names: Similarity
messages: Belongs to the peptidase M67A family.

9483:AQP9
gene id: 9483:AQP9
uniprot id: A0A8I3WZ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:MINDY1
gene id: 9483:MINDY1
uniprot id: F7C0Z2
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9483:DDX41
gene id: 9483:DDX41
uniprot id: U3F2W6
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

9483:AQP3
gene id: 9483:AQP3
uniprot id: F7CWZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9483:RNASET2
gene id: 9483:RNASET2
uniprot id: U3DHH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Lysosome lumen

9483:LOC100410496
gene id: 9483:LOC100410496
uniprot id: F7I9S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9483:FNBP1L
gene id: 9483:FNBP1L
uniprot id: F7G804
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9483:SDHAF4
gene id: 9483:SDHAF4
uniprot id: U3FCZ6
names: Similarity
messages: Belongs to the SDHAF4 family.

9483:CKAP5
gene id: 9483:CKAP5
uniprot id: U3EY20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

9483:PLCB2
gene id: 9483:PLCB2
uniprot id: A0A5F4WH25
uniprot id: F7I4D1
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9483:WASF3
gene id: 9483:WASF3
uniprot id: F7GRX8
uniprot id: F7GRZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9483:DTWD2
gene id: 9483:DTWD2
uniprot id: A0A2R8M4C7
names: Similarity
messages: Belongs to the TDD superfamily. DTWD2 family.

9483:MGAT5
gene id: 9483:MGAT5
uniprot id: U3BBB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9483:TGFBR2
gene id: 9483:TGFBR2
uniprot id: A0A2R8MMC4
uniprot id: F6ZQQ5
uniprot id: U3B8Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

9483:METTL15
gene id: 9483:METTL15
uniprot id: A0A8I3WZN5
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9483:PSMB10
gene id: 9483:PSMB10
uniprot id: U3DF12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9483:LOC100389518
gene id: 9483:LOC100389518
uniprot id: A0A2R8N9P5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9483:LOC100405000
gene id: 9483:LOC100405000
uniprot id: F6RXN0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9483:ADCY9
gene id: 9483:ADCY9
uniprot id: F6RS83
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9483:OLFM3
gene id: 9483:OLFM3
uniprot id: A0A2R8MJD5
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9483:LOC100411683
gene id: 9483:LOC100411683
uniprot id: B0VXB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PICALM
gene id: 9483:PICALM
uniprot id: A0A2R8N784
uniprot id: F7IBR4
uniprot id: U3BSF3
uniprot id: U3CPA6
uniprot id: U3DBE5
uniprot id: U3FFE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9483:LOC100386265
gene id: 9483:LOC100386265
uniprot id: A0A8I4A6I7
names: Similarity
messages: Belongs to the histone H3 family.

9483:AK2
gene id: 9483:AK2
uniprot id: U3BWM8
uniprot id: U3DKZ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9483:SLC66A3
gene id: 9483:SLC66A3
uniprot id: U3FIZ5
names: Subcellular Location Annotation
messages: Membrane

9483:BANF2
gene id: 9483:BANF2
uniprot id: A0A8I3WH01
names: Subcellular Location Annotation
messages: Nucleus

9483:HSPA9
gene id: 9483:HSPA9
uniprot id: U3D3A7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9483:BCLAF1
gene id: 9483:BCLAF1
uniprot id: U3B5H4
uniprot id: U3CYS9
uniprot id: U3F318
uniprot id: U3F882
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCLAF1/THRAP3 family.
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Nucleus

9483:POLR1E
gene id: 9483:POLR1E
uniprot id: U3CEZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9483:DCTN6
gene id: 9483:DCTN6
uniprot id: F7HWQ5
uniprot id: U3EUQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: cytoskeleton

9483:EYA1
gene id: 9483:EYA1
uniprot id: F7IGE4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9483:PITPNM1
gene id: 9483:PITPNM1
uniprot id: U3CSB1
uniprot id: U3FWY1
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9483:INPP5K
gene id: 9483:INPP5K
uniprot id: U3D8K9
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9483:CRCP
gene id: 9483:CRCP
uniprot id: F6TNU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9483:PSMG1
gene id: 9483:PSMG1
uniprot id: B0KW86
uniprot id: U3C6S6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity).
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Degraded by the proteasome upon completion of 20S proteasome maturation.
messages: Endoplasmic reticulum
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits (By similarity).
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9483:OGN
gene id: 9483:OGN
uniprot id: F7INR0
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9483:HARBI1
gene id: 9483:HARBI1
uniprot id: F6TKC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9483:ZSCAN2
gene id: 9483:ZSCAN2
uniprot id: A0A8I3WID1
uniprot id: U3FGU6
names: Subcellular Location Annotation
messages: Nucleus

9483:MS4A2
gene id: 9483:MS4A2
uniprot id: F6RHF4
names: Similarity
messages: Belongs to the MS4A family.

9483:TRIM3
gene id: 9483:TRIM3
uniprot id: F6X294
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9483:SMPDL3A
gene id: 9483:SMPDL3A
uniprot id: F7AAZ3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9483:NUP62
gene id: 9483:NUP62
uniprot id: F7IJB9
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

9483:NRTN
gene id: 9483:NRTN
uniprot id: F7ICQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9483:PTPRT
gene id: 9483:PTPRT
uniprot id: U3BNL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9483:SOD2
gene id: 9483:SOD2
uniprot id: Q8HXP0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-98 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
messages: Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.

9483:CDC26
gene id: 9483:CDC26
uniprot id: F7GVM0
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9483:MRPS31
gene id: 9483:MRPS31
uniprot id: F7DHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9483:METTL3
gene id: 9483:METTL3
uniprot id: U3CYA0
names: Similarity
messages: Belongs to the MT-A70-like family.

9483:SLC30A1
gene id: 9483:SLC30A1
uniprot id: U3CFK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9483:HMGCS1
gene id: 9483:HMGCS1
uniprot id: F6UT64
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9483:RPL5
gene id: 9483:RPL5
uniprot id: F7BQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9483:EIF4EBP1
gene id: 9483:EIF4EBP1
uniprot id: F6Y074
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9483:PRPF19
gene id: 9483:PRPF19
uniprot id: U3EI55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

9483:LOC100414558
gene id: 9483:LOC100414558
uniprot id: B0VXC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ZZZ3
gene id: 9483:ZZZ3
uniprot id: A0A8I3WAU6
uniprot id: F6PXI2
names: Subcellular Location Annotation
messages: Nucleus

9483:SLC41A2
gene id: 9483:SLC41A2
uniprot id: U3CH12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9483:CCNB1
gene id: 9483:CCNB1
uniprot id: F7I0H4
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

9483:TLCD3A
gene id: 9483:TLCD3A
uniprot id: F7IEA1
names: Subcellular Location Annotation
messages: Membrane

9483:OPN1SW
gene id: 9483:OPN1SW
uniprot id: F7GQA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: perinuclear region
messages: photoreceptor outer segment

9483:LPAR1
gene id: 9483:LPAR1
uniprot id: F6YCY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9483:TRAPPC13
gene id: 9483:TRAPPC13
uniprot id: F7I5K4
uniprot id: U3D2J8
uniprot id: U3DQW9
uniprot id: U3FIZ7
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9483:CPA6
gene id: 9483:CPA6
uniprot id: A0A5F4WBP8
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:TMEM14A
gene id: 9483:TMEM14A
uniprot id: U3DCF1
names: Similarity
messages: Belongs to the TMEM14 family.

9483:SERPINB3
gene id: 9483:SERPINB3
uniprot id: B0CMA6
names: Similarity
messages: Belongs to the serpin family.

9483:NNT
gene id: 9483:NNT
uniprot id: U3EPB3
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9483:PHKB
gene id: 9483:PHKB
uniprot id: F7ABD1
uniprot id: U3BJS0
uniprot id: U3E3H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9483:MNF1
gene id: 9483:MNF1
uniprot id: F6ZAL9
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9483:WNT5A
gene id: 9483:WNT5A
uniprot id: F7I9H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:ERH
gene id: 9483:ERH
uniprot id: F7ELJ3
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9483:GNB3
gene id: 9483:GNB3
uniprot id: F6VBL9
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9483:SMAD7
gene id: 9483:SMAD7
uniprot id: U3D430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9483:SSR1
gene id: 9483:SSR1
uniprot id: A0A2R8M539
uniprot id: F7HEV2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9483:CNOT10
gene id: 9483:CNOT10
uniprot id: A0A8I3WV29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

9483:CERS3
gene id: 9483:CERS3
uniprot id: F7I7W6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9483:EFNB3
gene id: 9483:EFNB3
uniprot id: U3E7W2
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SEM1
gene id: 9483:SEM1
uniprot id: F7C1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

9483:NHS
gene id: 9483:NHS
uniprot id: F7IAQ3
names: Similarity
messages: Belongs to the NHS family.

9483:HAT1
gene id: 9483:HAT1
uniprot id: A0A8I4A0E4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9483:SLC35E3
gene id: 9483:SLC35E3
uniprot id: F7AVQ7
names: Subcellular Location Annotation
messages: Membrane

9483:CD8A
gene id: 9483:CD8A
uniprot id: Q3LRP5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:EML1
gene id: 9483:EML1
uniprot id: A0A8J8YH14
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9483:JPH4
gene id: 9483:JPH4
uniprot id: U3CU54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9483:OCM2
gene id: 9483:OCM2
uniprot id: F7B9H4
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9483:NRP2
gene id: 9483:NRP2
uniprot id: U3D540
uniprot id: U3DFE5
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MDFI
gene id: 9483:MDFI
uniprot id: A0A8I3WUV7
names: Similarity
messages: Belongs to the MDFI family.

9483:CRK
gene id: 9483:CRK
uniprot id: F7DT53
names: Similarity
messages: Belongs to the CRK family.

9483:B4GALT3
gene id: 9483:B4GALT3
uniprot id: U3D0P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9483:IER2
gene id: 9483:IER2
uniprot id: F7IPF6
names: Similarity
messages: Belongs to the IER family.

9483:CAMK4
gene id: 9483:CAMK4
uniprot id: F7I122
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:TCF25
gene id: 9483:TCF25
uniprot id: F6R706
uniprot id: U3FVD4
names: Similarity
messages: Belongs to the TCF25 family.

9483:PRKAR1B
gene id: 9483:PRKAR1B
uniprot id: U3ERD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9483:RPLP0
gene id: 9483:RPLP0
uniprot id: F6WAG2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9483:CWF19L1
gene id: 9483:CWF19L1
uniprot id: F7IRP5
names: Similarity
messages: Belongs to the CWF19 family.

9483:CNEP1R1
gene id: 9483:CNEP1R1
uniprot id: A0A8I3WNI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9483:GPM6A
gene id: 9483:GPM6A
uniprot id: F7EFH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9483:WFDC5
gene id: 9483:WFDC5
uniprot id: A4K2U0
names: Function
names: Subcellular Location Annotation
messages: Putative acid-stable proteinase inhibitor.
messages: Secreted

9483:CHRNB2
gene id: 9483:CHRNB2
uniprot id: F7HLC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:VPS13B
gene id: 9483:VPS13B
uniprot id: F7CGZ2
uniprot id: U3F2K7
names: Similarity
messages: Belongs to the VPS13 family.

9483:LOC103793369
gene id: 9483:LOC103793369
uniprot id: A0A7R8C3E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:PEX5
gene id: 9483:PEX5
uniprot id: U3CWR8
uniprot id: U3DKH6
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9483:RNASE12
gene id: 9483:RNASE12
uniprot id: W0UVB8
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9483:TM9SF4
gene id: 9483:TM9SF4
uniprot id: A0A8I3WG80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9483:GSTO2
gene id: 9483:GSTO2
uniprot id: A0A2R8MSP9
uniprot id: A0A7G3HPU4
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9483:EIF1AD
gene id: 9483:EIF1AD
uniprot id: F7EAC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9483:FGFBP1
gene id: 9483:FGFBP1
uniprot id: F7IHM9
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9483:VIM
gene id: 9483:VIM
uniprot id: F7BQY8
names: Similarity
messages: Belongs to the intermediate filament family.

9483:KIF5C
gene id: 9483:KIF5C
uniprot id: U3EUR0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:FCER1G
gene id: 9483:FCER1G
uniprot id: F7I6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9483:INSIG2
gene id: 9483:INSIG2
uniprot id: A0A5F4VWK9
uniprot id: B0CMA4
uniprot id: U3CHF3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with RNF139. Interacts with RNF145.
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane
messages: Oxidized at Cys-215 in differentiated myotubes, preventing ubiquitination at the same site, and resulting in protein stabilization.
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139.
messages: Phosphorylation at Ser-151 by PCK1 reduces binding to oxysterol, disrupting the interaction between INSIG2 and SCAP, thereby promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes.
messages: Polyubiquitinated by AMFR/gp78 at Cys-215 in some tissues such as adipose tissues, undifferentiated myoblasts and liver, leading to its degradation. In differentiated myotubes, Cys-215 oxidation prevents ubiquitination at the same site, resulting in protein stabilization.
messages: The KxHxx motif mediates association with the coatomer complex.

9483:MNAT1
gene id: 9483:MNAT1
uniprot id: F7I1L8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9483:LOC100385683
gene id: 9483:LOC100385683
uniprot id: A0A2R8P0B6
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9483:SCAMP1
gene id: 9483:SCAMP1
uniprot id: F6TX27
uniprot id: F6U6N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9483:FOXO4
gene id: 9483:FOXO4
uniprot id: U3E3C7
names: Subcellular Location Annotation
messages: Nucleus

9483:NTNG1
gene id: 9483:NTNG1
uniprot id: U3EJD3
uniprot id: U3EV01
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MEF2B
gene id: 9483:MEF2B
uniprot id: U3F2R9
names: Subcellular Location Annotation
messages: Nucleus

9483:HAGH
gene id: 9483:HAGH
uniprot id: Q28333
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A mitochondrial longer isoform in the N-terminus has been proven to exist in orthologs.
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cloning artifact.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.
messages: Testis.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

9483:ENPP1
gene id: 9483:ENPP1
uniprot id: F7HLD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9483:DNTT
gene id: 9483:DNTT
uniprot id: F6RGZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

9483:DEFB134
gene id: 9483:DEFB134
uniprot id: A0A8I3WYR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:NDUFB3
gene id: 9483:NDUFB3
uniprot id: F7HNF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9483:CFAP206
gene id: 9483:CFAP206
uniprot id: A0A8I3VYY0
uniprot id: A0A8I3WGX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme

9483:MUL1
gene id: 9483:MUL1
uniprot id: U3F761
names: Subcellular Location Annotation
messages: Membrane

9483:FYN
gene id: 9483:FYN
uniprot id: F7IB43
uniprot id: U3BSY6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:NME1
gene id: 9483:NME1
uniprot id: F6VUS6
names: Similarity
messages: Belongs to the NDK family.

9483:CASP10
gene id: 9483:CASP10
uniprot id: U3CWK6
names: Similarity
messages: Belongs to the peptidase C14A family.

9483:ISOC2
gene id: 9483:ISOC2
uniprot id: U3BJN1
names: Similarity
messages: Belongs to the isochorismatase family.

9483:ORMDL1
gene id: 9483:ORMDL1
uniprot id: F7FQP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9483:HOXB8
gene id: 9483:HOXB8
uniprot id: A0A2R8N4V1
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100398205
gene id: 9483:LOC100398205
uniprot id: A0A2R8MUI6
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:PNLIPRP3
gene id: 9483:PNLIPRP3
uniprot id: A0A5F4WD72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9483:CCN1
gene id: 9483:CCN1
uniprot id: F7I1R4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:SEC61A1
gene id: 9483:SEC61A1
uniprot id: F7F6Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:RNF13
gene id: 9483:RNF13
uniprot id: F7HBJ4
names: Subcellular Location Annotation
messages: Membrane

9483:PROKR1
gene id: 9483:PROKR1
uniprot id: F7ISJ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:NEUROD2
gene id: 9483:NEUROD2
uniprot id: F7ILB4
names: Subcellular Location Annotation
messages: Nucleus

9483:IDS
gene id: 9483:IDS
uniprot id: F7EJG2
names: Similarity
messages: Belongs to the sulfatase family.

9483:PIANP
gene id: 9483:PIANP
uniprot id: A0A2R8MRS9
names: Subcellular Location Annotation
messages: Membrane

9483:SDC4
gene id: 9483:SDC4
uniprot id: A4K2U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9483:PLLP
gene id: 9483:PLLP
uniprot id: F7H4F3
names: Subcellular Location Annotation
messages: Membrane

9483:HMOX2
gene id: 9483:HMOX2
uniprot id: F7IJ83
names: Similarity
messages: Belongs to the heme oxygenase family.

9483:HACD3
gene id: 9483:HACD3
uniprot id: A0A8I3W6C9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:MED31
gene id: 9483:MED31
uniprot id: F7I0Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9483:SLC10A5
gene id: 9483:SLC10A5
uniprot id: F7HA47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9483:SNCB
gene id: 9483:SNCB
uniprot id: U3AQC0
names: Similarity
messages: Belongs to the synuclein family.

9483:CNIH3
gene id: 9483:CNIH3
uniprot id: F7HXG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9483:BNIP1
gene id: 9483:BNIP1
uniprot id: F7HD41
names: Subcellular Location Annotation
messages: Membrane

9483:LGI3
gene id: 9483:LGI3
uniprot id: U3F159
names: Subcellular Location Annotation
messages: Secreted

9483:TPM1
gene id: 9483:TPM1
uniprot id: A0A8J8XPA2
uniprot id: A0A8J8YJA3
uniprot id: F6YS84
uniprot id: U3FTU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9483:IFT20
gene id: 9483:IFT20
uniprot id: A0A2R8MRU5
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9483:IL5
gene id: 9483:IL5
uniprot id: Q0Z974
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9483:SPA17
gene id: 9483:SPA17
uniprot id: Q9XT29
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9483:AVL9
gene id: 9483:AVL9
uniprot id: A0A8J8YF10
uniprot id: U3D6Q3
names: Subcellular Location Annotation
messages: Recycling endosome

9483:SRPX
gene id: 9483:SRPX
uniprot id: U3BB10
uniprot id: U3CBQ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CLDN11
gene id: 9483:CLDN11
uniprot id: F6Y431
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:LHCGR
gene id: 9483:LHCGR
uniprot id: O02721
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Sulfated.

9483:NKAIN2
gene id: 9483:NKAIN2
uniprot id: U3C7Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9483:CLPS
gene id: 9483:CLPS
uniprot id: F7HYJ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9483:SLC25A25
gene id: 9483:SLC25A25
uniprot id: A0A5K1TZ61
uniprot id: F6YJ93
uniprot id: F6YJA1
uniprot id: U3E298
uniprot id: U3FRM1
uniprot id: U3FVU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:NEMF
gene id: 9483:NEMF
uniprot id: U3CHM6
names: Similarity
messages: Belongs to the NEMF family.

9483:CCNL2
gene id: 9483:CCNL2
uniprot id: F7FXM5
names: Similarity
messages: Belongs to the cyclin family.

9483:SLC25A39
gene id: 9483:SLC25A39
uniprot id: F6VZN0
uniprot id: U3DW85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9483:NDP
gene id: 9483:NDP
uniprot id: U3EC42
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:GTPBP3
gene id: 9483:GTPBP3
uniprot id: F6YWZ5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9483:SFXN1
gene id: 9483:SFXN1
uniprot id: F7F6B4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9483:TRIM4
gene id: 9483:TRIM4
uniprot id: F6UD69
uniprot id: F7CQC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:NUF2
gene id: 9483:NUF2
uniprot id: F6PHA6
names: Similarity
messages: Belongs to the NUF2 family.

9483:LPAR6
gene id: 9483:LPAR6
uniprot id: U3BLR3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:SLC44A2
gene id: 9483:SLC44A2
uniprot id: U3EU51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9483:RGS7BP
gene id: 9483:RGS7BP
uniprot id: F6XC06
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9483:COPS4
gene id: 9483:COPS4
uniprot id: U3FN66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9483:DOP1A
gene id: 9483:DOP1A
uniprot id: U3F9R1
names: Similarity
messages: Belongs to the dopey family.

9483:PTOV1
gene id: 9483:PTOV1
uniprot id: F6T3A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
messages: Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: May interact with CREBBP. Interacts with FLOT1.
messages: Nucleus
messages: perinuclear region

9483:PSIP1
gene id: 9483:PSIP1
uniprot id: F7IFC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9483:LOC100393797
gene id: 9483:LOC100393797
uniprot id: F7IJU8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9483:RIOK1
gene id: 9483:RIOK1
uniprot id: F7G1T7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9483:LOC100401354
gene id: 9483:LOC100401354
uniprot id: F6ZYH3
names: Similarity
messages: Belongs to the complex I LYR family.

9483:ADGRG1
gene id: 9483:ADGRG1
uniprot id: U3C7R1
uniprot id: U3EUN1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9483:AR
gene id: 9483:AR
uniprot id: F7GJ39
names: Similarity
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.

9483:TMOD4
gene id: 9483:TMOD4
uniprot id: B0KWB6
names: Subcellular Location Annotation
messages: cytoskeleton

9483:TNFSF12
gene id: 9483:TNFSF12
uniprot id: F7FJI7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:PDHA1
gene id: 9483:PDHA1
uniprot id: U3FGT0
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9483:TFCP2L1
gene id: 9483:TFCP2L1
uniprot id: F7G0J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9483:HASPIN
gene id: 9483:HASPIN
uniprot id: F7GU79
names: Subcellular Location Annotation
messages: Chromosome

9483:UNC13B
gene id: 9483:UNC13B
uniprot id: U3CPW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-13 family.
messages: Cytoplasm
messages: Membrane

9483:NUP58
gene id: 9483:NUP58
uniprot id: U3EP89
names: Subcellular Location Annotation
messages: nuclear pore complex

9483:GALR1
gene id: 9483:GALR1
uniprot id: A0A8I3WUP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:GLYCTK
gene id: 9483:GLYCTK
uniprot id: F7IB83
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9483:ORMDL3
gene id: 9483:ORMDL3
uniprot id: F7H4F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9483:LOC100389781
gene id: 9483:LOC100389781
uniprot id: U3DFP9
names: Function
names: Subunit
messages: Interacts with CD4. Interacts with ALDH16A1.
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9483:LOC100414863
gene id: 9483:LOC100414863
uniprot id: F7FBY9
names: Similarity
messages: Belongs to the GAGE family.

9483:DTYMK
gene id: 9483:DTYMK
uniprot id: F7ED91
names: Similarity
messages: Belongs to the thymidylate kinase family.

9483:VWC2L
gene id: 9483:VWC2L
uniprot id: F6TJC5
names: Subcellular Location Annotation
messages: Synapse

9483:LOC100407125
gene id: 9483:LOC100407125
uniprot id: F6U3I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9483:IL2RA
gene id: 9483:IL2RA
uniprot id: Q19LH5
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9483:XCR1
gene id: 9483:XCR1
uniprot id: F7HJW0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:DUSP1
gene id: 9483:DUSP1
uniprot id: U3FNS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9483:CPPED1
gene id: 9483:CPPED1
uniprot id: F7HL73
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9483:GORASP2
gene id: 9483:GORASP2
uniprot id: F6Z4V2
names: Similarity
messages: Belongs to the GORASP family.

9483:KCNMB1
gene id: 9483:KCNMB1
uniprot id: F6R0K0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9483:TGIF2
gene id: 9483:TGIF2
uniprot id: F7IBT3
names: Subcellular Location Annotation
messages: Nucleus

9483:GDF2
gene id: 9483:GDF2
uniprot id: F6UYA9
names: Similarity
messages: Belongs to the TGF-beta family.

9483:EPHA1
gene id: 9483:EPHA1
uniprot id: F7I7A7
names: Subcellular Location Annotation
messages: Membrane

9483:EAF2
gene id: 9483:EAF2
uniprot id: A0A8J8YCI6
names: Similarity
messages: Belongs to the EAF family.

9483:UMPS
gene id: 9483:UMPS
uniprot id: U3E3B4
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9483:EVL
gene id: 9483:EVL
uniprot id: A0A8J8YCD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9483:ENY2
gene id: 9483:ENY2
uniprot id: U3FW45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9483:UNC5A
gene id: 9483:UNC5A
uniprot id: F6ZXV4
uniprot id: U3FSB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9483:HSPA4L
gene id: 9483:HSPA4L
uniprot id: U3B6H3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9483:TMEM230
gene id: 9483:TMEM230
uniprot id: F6UFQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9483:HSD17B3
gene id: 9483:HSD17B3
uniprot id: A0A8I3W2T7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:SKA2
gene id: 9483:SKA2
uniprot id: U3DQH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

9483:SUSD4
gene id: 9483:SUSD4
uniprot id: U3DA72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SESN3
gene id: 9483:SESN3
uniprot id: F6T2D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9483:DKK2
gene id: 9483:DKK2
uniprot id: A0A5F4WB29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9483:GDPD1
gene id: 9483:GDPD1
uniprot id: A0A5F4WCD7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9483:SSBP3
gene id: 9483:SSBP3
uniprot id: F7HIR6
uniprot id: F7IAZ3
uniprot id: U3FUU1
names: Subcellular Location Annotation
messages: Nucleus

9483:FGF9
gene id: 9483:FGF9
uniprot id: F7I3P1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:RPS27L
gene id: 9483:RPS27L
uniprot id: F7HWT8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:FOXP3
gene id: 9483:FOXP3
uniprot id: C7EPD6
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100400370
gene id: 9483:LOC100400370
uniprot id: A0A2R8MU46
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9483:SGTB
gene id: 9483:SGTB
uniprot id: F7I0S4
names: Similarity
messages: Belongs to the SGT family.

9483:SUCLG2
gene id: 9483:SUCLG2
uniprot id: U3EK93
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9483:PPM1G
gene id: 9483:PPM1G
uniprot id: F7BFT9
names: Similarity
messages: Belongs to the PP2C family.

9483:GLRA4
gene id: 9483:GLRA4
uniprot id: F6QEB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9483:TNKS2
gene id: 9483:TNKS2
uniprot id: U3C2N9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:LOC100388732
gene id: 9483:LOC100388732
uniprot id: B0VXB5
uniprot id: Q9GJS7
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
messages: Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).
messages: Red blood cells.

9483:ADSL
gene id: 9483:ADSL
uniprot id: U3EF93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

9483:HDAC10
gene id: 9483:HDAC10
uniprot id: U3FQ71
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.

9483:BICD1
gene id: 9483:BICD1
uniprot id: A0A8I3WHB3
uniprot id: F6Q1B3
uniprot id: F6QBM4
names: Similarity
messages: Belongs to the BicD family.

9483:XKR5
gene id: 9483:XKR5
uniprot id: F6PU51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9483:LOC100390933
gene id: 9483:LOC100390933
uniprot id: F7B755
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9483:HS3ST5
gene id: 9483:HS3ST5
uniprot id: A0A8I4A0Y7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9483:TENT5C
gene id: 9483:TENT5C
uniprot id: U3BX57
names: Similarity
messages: Belongs to the TENT family.

9483:MAB21L1
gene id: 9483:MAB21L1
uniprot id: F7DWX9
names: Similarity
messages: Belongs to the mab-21 family.

9483:RARS2
gene id: 9483:RARS2
uniprot id: F6Z0R1
uniprot id: U3BS49
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9483:PRIM2
gene id: 9483:PRIM2
uniprot id: U3BC63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.

9483:LOC100413569
gene id: 9483:LOC100413569
uniprot id: A0A8I3XB20
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:SEPTIN2
gene id: 9483:SEPTIN2
uniprot id: U3FNX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9483:MORF4L1
gene id: 9483:MORF4L1
uniprot id: A0A5F4VST9
uniprot id: U3F3Z8
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100390201
gene id: 9483:LOC100390201
uniprot id: A0A2R8MXF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:GRP
gene id: 9483:GRP
uniprot id: F7DIJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9483:GRIA3
gene id: 9483:GRIA3
uniprot id: F7IP00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9483:SMG7
gene id: 9483:SMG7
uniprot id: U3BG63
uniprot id: U3BZ42
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

9483:CLN8
gene id: 9483:CLN8
uniprot id: F7I8I0
names: Subcellular Location Annotation
messages: Membrane

9483:GHRH
gene id: 9483:GHRH
uniprot id: A0A8I3W2I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9483:MYH1
gene id: 9483:MYH1
uniprot id: F7FKN4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:GPR34
gene id: 9483:GPR34
uniprot id: Q6XCG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor.

9483:NEMP1
gene id: 9483:NEMP1
uniprot id: A0A2R8MN53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9483:HMGA1
gene id: 9483:HMGA1
uniprot id: F7HUN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9483:NGRN
gene id: 9483:NGRN
uniprot id: F6Z313
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9483:CFLAR
gene id: 9483:CFLAR
uniprot id: F7IMN8
names: Similarity
messages: Belongs to the peptidase C14A family.

9483:CIAO2A
gene id: 9483:CIAO2A
uniprot id: A0A8I3WYR8
uniprot id: F7IHH5
names: Similarity
messages: Belongs to the MIP18 family.

9483:SLU7
gene id: 9483:SLU7
uniprot id: U3DZ06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9483:TXLNA
gene id: 9483:TXLNA
uniprot id: F7EWF4
names: Similarity
messages: Belongs to the taxilin family.

9483:TSPAN11
gene id: 9483:TSPAN11
uniprot id: U3DFF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:SGCE
gene id: 9483:SGCE
uniprot id: A0A5K1U701
uniprot id: F6SLC1
uniprot id: U3D1I1
uniprot id: U3ET27
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

9483:GNB2
gene id: 9483:GNB2
uniprot id: U3F085
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9483:SF3B6
gene id: 9483:SF3B6
uniprot id: U3EW04
names: Subcellular Location Annotation
messages: Nucleus

9483:NAA38
gene id: 9483:NAA38
uniprot id: F7DEN2
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

9483:TRMT11
gene id: 9483:TRMT11
uniprot id: U3FI61
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

9483:VANGL1
gene id: 9483:VANGL1
uniprot id: U3D5G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9483:CCS
gene id: 9483:CCS
uniprot id: D2KTC2
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9483:GNA12
gene id: 9483:GNA12
uniprot id: F7HMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9483:SMUG1
gene id: 9483:SMUG1
uniprot id: F7I3E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9483:DDAH1
gene id: 9483:DDAH1
uniprot id: F7B3R1
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9483:PIGK
gene id: 9483:PIGK
uniprot id: U3BHU8
names: Similarity
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.

9483:DRD5
gene id: 9483:DRD5
uniprot id: F6UEN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:FGF14
gene id: 9483:FGF14
uniprot id: A0A2R8PC64
uniprot id: U3FT30
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:CDH19
gene id: 9483:CDH19
uniprot id: F7IA45
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:PCSK1
gene id: 9483:PCSK1
uniprot id: U3F9M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9483:LOC100395489
gene id: 9483:LOC100395489
uniprot id: A0A8I3WPU1
names: Similarity
messages: Belongs to the pro/parathymosin family.

9483:CARMIL3
gene id: 9483:CARMIL3
uniprot id: F7BFA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9483:TMBIM6
gene id: 9483:TMBIM6
uniprot id: A0A2R8MGV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9483:SUPV3L1
gene id: 9483:SUPV3L1
uniprot id: F7FZQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9483:MBOAT2
gene id: 9483:MBOAT2
uniprot id: U3C8F4
names: Subcellular Location Annotation
messages: Membrane

9483:LIMS1
gene id: 9483:LIMS1
uniprot id: F7BUC0
uniprot id: U3B8D6
uniprot id: U3E3I9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9483:CLDN14
gene id: 9483:CLDN14
uniprot id: F7C3D9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:MRPL18
gene id: 9483:MRPL18
uniprot id: F6T3Q3
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9483:SAMD8
gene id: 9483:SAMD8
uniprot id: U3EKZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9483:LOC100406470
gene id: 9483:LOC100406470
uniprot id: H9KXU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ADGRL2
gene id: 9483:ADGRL2
uniprot id: U3FSP2
names: Subcellular Location Annotation
messages: Membrane

9483:TMEM242
gene id: 9483:TMEM242
uniprot id: F7G9P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9483:GABRA5
gene id: 9483:GABRA5
uniprot id: U3C1H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:MEF2A
gene id: 9483:MEF2A
uniprot id: F7HSJ6
uniprot id: U3DEP8
uniprot id: U3EXX2
uniprot id: U3F6J9
names: Subcellular Location Annotation
messages: Nucleus

9483:SNRNP27
gene id: 9483:SNRNP27
uniprot id: F7F836
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9483:VAT1L
gene id: 9483:VAT1L
uniprot id: U3FTD7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9483:UPF3A
gene id: 9483:UPF3A
uniprot id: F7IFT2
names: Similarity
messages: Belongs to the RENT3 family.

9483:GCSH
gene id: 9483:GCSH
uniprot id: U3CM87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9483:LOC103796754
gene id: 9483:LOC103796754
uniprot id: A0A8I3W2H5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

9483:TRPT1
gene id: 9483:TRPT1
uniprot id: U3CEU2
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

9483:LEAP2
gene id: 9483:LEAP2
uniprot id: B0KWP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9483:FKRP
gene id: 9483:FKRP
uniprot id: F6TG30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9483:METTL26
gene id: 9483:METTL26
uniprot id: F6T1P9
uniprot id: F7C369
names: Similarity
messages: Belongs to the UPF0585 family.

9483:LOC100411835
gene id: 9483:LOC100411835
uniprot id: A0A8I4A167
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9483:PDE7A
gene id: 9483:PDE7A
uniprot id: F7IHC1
uniprot id: F7IJN4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:CAMK2D
gene id: 9483:CAMK2D
uniprot id: A0A2R8M8I7
uniprot id: A0A2R8MP59
uniprot id: A0A2R8PG23
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9483:SLC25A26
gene id: 9483:SLC25A26
uniprot id: F6UCJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:ABL1
gene id: 9483:ABL1
uniprot id: U3BH45
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:SLC45A3
gene id: 9483:SLC45A3
uniprot id: A0A2R8MSZ7
names: Subcellular Location Annotation
messages: Membrane

9483:ARTN
gene id: 9483:ARTN
uniprot id: F6PVA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9483:RPS26
gene id: 9483:RPS26
uniprot id: A0A2R8MZE0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9483:PARP2
gene id: 9483:PARP2
uniprot id: F7FIN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9483:NDUFC1
gene id: 9483:NDUFC1
uniprot id: F7IC73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:MRPS25
gene id: 9483:MRPS25
uniprot id: F7HYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9483:DTNB
gene id: 9483:DTNB
uniprot id: F7GZQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9483:THUMPD2
gene id: 9483:THUMPD2
uniprot id: A0A5F4W7R1
uniprot id: F7G5B3
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9483:SLITRK2
gene id: 9483:SLITRK2
uniprot id: F7IN27
names: Similarity
messages: Belongs to the SLITRK family.

9483:STMN2
gene id: 9483:STMN2
uniprot id: U3EIE6
names: Similarity
messages: Belongs to the stathmin family.

9483:RRM1
gene id: 9483:RRM1
uniprot id: F6ZKF5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9483:HBM
gene id: 9483:HBM
uniprot id: B0VX77
names: Similarity
messages: Belongs to the globin family.

9483:MYOC
gene id: 9483:MYOC
uniprot id: A0A8I3XF71
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SPATS2L
gene id: 9483:SPATS2L
uniprot id: A0A8I3WA21
uniprot id: U3DH00
uniprot id: U3ENF9
names: Similarity
messages: Belongs to the SPATS2 family.

9483:MARF1
gene id: 9483:MARF1
uniprot id: U3F7E5
names: Subcellular Location Annotation
messages: Peroxisome

9483:NR2F2
gene id: 9483:NR2F2
uniprot id: F7ICX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9483:HSDL2
gene id: 9483:HSDL2
uniprot id: U3FND2
names: Subcellular Location Annotation
messages: Peroxisome

9483:SCO1
gene id: 9483:SCO1
uniprot id: A0A8J8Y5X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

9483:NOL12
gene id: 9483:NOL12
uniprot id: U3D4W1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

9483:XRCC5
gene id: 9483:XRCC5
uniprot id: U3E6P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

9483:PTPN2
gene id: 9483:PTPN2
uniprot id: U3DFJ3
uniprot id: U3FTG6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9483:POMGNT1
gene id: 9483:POMGNT1
uniprot id: U3BTL9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9483:WRNIP1
gene id: 9483:WRNIP1
uniprot id: F7D6S4
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

9483:SQLE
gene id: 9483:SQLE
uniprot id: F7HNP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9483:MRPL30
gene id: 9483:MRPL30
uniprot id: A0A8J8XZK6
uniprot id: U3D6P9
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9483:VPS26C
gene id: 9483:VPS26C
uniprot id: F7ALR6
uniprot id: F7ALS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9483:SHKBP1
gene id: 9483:SHKBP1
uniprot id: F7G6M1
names: Similarity
messages: Belongs to the KCTD3 family.

9483:LOC100414961
gene id: 9483:LOC100414961
uniprot id: A0A2R8MYK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:TMEM106A
gene id: 9483:TMEM106A
uniprot id: F7I1J6
names: Similarity
messages: Belongs to the TMEM106 family.

9483:MOCS3
gene id: 9483:MOCS3
uniprot id: F7GUM3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

9483:OR6N2
gene id: 9483:OR6N2
uniprot id: F7HXL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:ISCU
gene id: 9483:ISCU
uniprot id: U3DV20
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex.

9483:ATP1A3
gene id: 9483:ATP1A3
uniprot id: A0A8I4A1P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9483:CPT2
gene id: 9483:CPT2
uniprot id: F7IPZ3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9483:CMPK2
gene id: 9483:CMPK2
uniprot id: A0A8I3WJ17
names: Similarity
messages: Belongs to the thymidylate kinase family.

9483:SLC26A1
gene id: 9483:SLC26A1
uniprot id: F7EMH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate.

9483:NKX2-8
gene id: 9483:NKX2-8
uniprot id: A0A2R8MHW5
names: Subcellular Location Annotation
messages: Nucleus

9483:BBS7
gene id: 9483:BBS7
uniprot id: U3EBP5
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9483:CCT5
gene id: 9483:CCT5
uniprot id: F6Y1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9483:COPS6
gene id: 9483:COPS6
uniprot id: F6XZK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

9483:ELP6
gene id: 9483:ELP6
uniprot id: A0A8J8YT58
names: Similarity
messages: Belongs to the ELP6 family.

9483:KDM1A
gene id: 9483:KDM1A
uniprot id: F7HZ54
uniprot id: U3BZN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

9483:LOC100391740
gene id: 9483:LOC100391740
uniprot id: B0VX98
names: Subcellular Location Annotation
messages: Membrane

9483:RGS2
gene id: 9483:RGS2
uniprot id: F7HJN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: nucleolus

9483:OR2T11
gene id: 9483:OR2T11
uniprot id: F7HDZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:FLI1
gene id: 9483:FLI1
uniprot id: U3BDK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:SLC7A14
gene id: 9483:SLC7A14
uniprot id: F6W919
names: Subcellular Location Annotation
messages: Membrane

9483:LOC100396744
gene id: 9483:LOC100396744
uniprot id: U3CM30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:EYA2
gene id: 9483:EYA2
uniprot id: F7HWD0
uniprot id: U3ECE7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9483:HOXB13
gene id: 9483:HOXB13
uniprot id: F7BWB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9483:GASK1B
gene id: 9483:GASK1B
uniprot id: A0A5K1U419
names: Similarity
messages: Belongs to the GASK family.

9483:FA2H
gene id: 9483:FA2H
uniprot id: F7I985
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:SLCO3A1
gene id: 9483:SLCO3A1
uniprot id: F7IEX0
uniprot id: U3DDR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9483:TMEM170B
gene id: 9483:TMEM170B
uniprot id: U3F5M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9483:BMP7
gene id: 9483:BMP7
uniprot id: U3CV29
names: Similarity
messages: Belongs to the TGF-beta family.

9483:AMD1
gene id: 9483:AMD1
uniprot id: U3DMU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9483:RTRAF
gene id: 9483:RTRAF
uniprot id: U3DVX0
uniprot id: U3EBH0
names: Similarity
messages: Belongs to the RTRAF family.

9483:CCL22
gene id: 9483:CCL22
uniprot id: A0A8I3WKT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:CPVL
gene id: 9483:CPVL
uniprot id: F7GPF2
names: Similarity
messages: Belongs to the peptidase S10 family.

9483:PKD2
gene id: 9483:PKD2
uniprot id: A0A5F4W9Q9
uniprot id: U3F411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

9483:SS18
gene id: 9483:SS18
uniprot id: U3CMU6
uniprot id: U3FL36
names: Similarity
messages: Belongs to the SS18 family.

9483:SMARCAD1
gene id: 9483:SMARCAD1
uniprot id: A0A5K1UF91
names: Subcellular Location Annotation
messages: Chromosome

9483:SLC13A4
gene id: 9483:SLC13A4
uniprot id: U3E7C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9483:NKIRAS1
gene id: 9483:NKIRAS1
uniprot id: F7H5N4
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9483:SNX32
gene id: 9483:SNX32
uniprot id: F7F0Y1
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9483:KIF2A
gene id: 9483:KIF2A
uniprot id: A0A2R8MFK6
uniprot id: U3BC72
uniprot id: U3DRA9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:SULT1B1
gene id: 9483:SULT1B1
uniprot id: A0A7G3QNV8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9483:MOB2
gene id: 9483:MOB2
uniprot id: U3CXE9
names: Similarity
messages: Belongs to the MOB1/phocein family.

9483:GPSM2
gene id: 9483:GPSM2
uniprot id: U3D953
names: Similarity
messages: Belongs to the GPSM family.

9483:HMCES
gene id: 9483:HMCES
uniprot id: F7H7D8
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9483:PTGES3
gene id: 9483:PTGES3
uniprot id: A0A2R8MSN2
uniprot id: F7CND0
uniprot id: U3BK01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9483:INTS7
gene id: 9483:INTS7
uniprot id: U3AS40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9483:BTG3
gene id: 9483:BTG3
uniprot id: F7H6J9
names: Similarity
messages: Belongs to the BTG family.

9483:CCNQ
gene id: 9483:CCNQ
uniprot id: A0A8J8XV73
uniprot id: F7GVF7
names: Similarity
messages: Belongs to the cyclin family. Cyclin-like FAM58 subfamily.

9483:CDK14
gene id: 9483:CDK14
uniprot id: A0A2R8MEH5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:CORT
gene id: 9483:CORT
uniprot id: F7I1I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9483:DMRTA2
gene id: 9483:DMRTA2
uniprot id: A0A2R8MD45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9483:PFKFB2
gene id: 9483:PFKFB2
uniprot id: A0A8I3X071
uniprot id: F6VUU1
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9483:PPIB
gene id: 9483:PPIB
uniprot id: F7ISM3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:DNAJC10
gene id: 9483:DNAJC10
uniprot id: A0A5F4VYX5
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.
messages: Endoplasmic reticulum lumen

9483:GALNT4
gene id: 9483:GALNT4
uniprot id: U3BW57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:B4GALNT2
gene id: 9483:B4GALNT2
uniprot id: F6ZYQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

9483:NPL
gene id: 9483:NPL
uniprot id: U3D488
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9483:PREPL
gene id: 9483:PREPL
uniprot id: F7HE24
uniprot id: U3BKQ0
names: Similarity
messages: Belongs to the peptidase S9A family.

9483:OSBPL1A
gene id: 9483:OSBPL1A
uniprot id: U3FP94
names: Similarity
messages: Belongs to the OSBP family.

9483:FOXI1
gene id: 9483:FOXI1
uniprot id: A0A8I3X8U8
names: Subcellular Location Annotation
messages: Nucleus

9483:PRICKLE2
gene id: 9483:PRICKLE2
uniprot id: U3EPY0
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9483:FAM149A
gene id: 9483:FAM149A
uniprot id: U3BSE2
names: Similarity
messages: Belongs to the FAM149 family.

9483:DYNC1I1
gene id: 9483:DYNC1I1
uniprot id: F6S1D1
uniprot id: F6SCA4
uniprot id: U3CMA6
uniprot id: U3D6B8
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9483:MECOM
gene id: 9483:MECOM
uniprot id: F6SYP4
uniprot id: U3DP30
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100404555
gene id: 9483:LOC100404555
uniprot id: F7ID46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:RPS3A
gene id: 9483:RPS3A
uniprot id: F7FTX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9483:TEFM
gene id: 9483:TEFM
uniprot id: F7IE95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEFM family.
messages: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
messages: mitochondrion nucleoid

9483:TET2
gene id: 9483:TET2
uniprot id: F7B2Z8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9483:PHTF1
gene id: 9483:PHTF1
uniprot id: U3FJ49
names: Subcellular Location Annotation
messages: Membrane

9483:B2M
gene id: 9483:B2M
uniprot id: P63061
uniprot id: U3FI69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.
messages: Secreted

9483:LOC100386021
gene id: 9483:LOC100386021
uniprot id: F7HAW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9483:PDXP
gene id: 9483:PDXP
uniprot id: U3E5L2
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

9483:LAMTOR2
gene id: 9483:LAMTOR2
uniprot id: F7IBS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9483:OR10S1
gene id: 9483:OR10S1
uniprot id: F7IT56
names: Subcellular Location Annotation
messages: Membrane

9483:REN
gene id: 9483:REN
uniprot id: Q9TSZ1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.
messages: Interacts with ATP6AP2.
messages: Membrane
messages: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
messages: Secreted

9483:RABGGTA
gene id: 9483:RABGGTA
uniprot id: F7FA20
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9483:KIFC1
gene id: 9483:KIFC1
uniprot id: F7IR24
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:FAM13B
gene id: 9483:FAM13B
uniprot id: F6XUV0
names: Similarity
messages: Belongs to the FAM13 family.

9483:SCG2
gene id: 9483:SCG2
uniprot id: U3FS88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Interacts with Secretogranin III/SCG3.
messages: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
messages: Secreted

9483:ORAI3
gene id: 9483:ORAI3
uniprot id: F7I315
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9483:CNGA4
gene id: 9483:CNGA4
uniprot id: F7I9D4
names: Subcellular Location Annotation
messages: Membrane

9483:CCT7
gene id: 9483:CCT7
uniprot id: F6TEX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9483:B3GALNT2
gene id: 9483:B3GALNT2
uniprot id: U3D6G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:CHST3
gene id: 9483:CHST3
uniprot id: F6UUA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9483:UROC1
gene id: 9483:UROC1
uniprot id: F6S143
names: Similarity
messages: Belongs to the urocanase family.

9483:RRS1
gene id: 9483:RRS1
uniprot id: U3FNM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9483:OPN3
gene id: 9483:OPN3
uniprot id: F7IH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:OTULIN
gene id: 9483:OTULIN
uniprot id: A0A8J8Y147
uniprot id: U3AV46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9483:SENP8
gene id: 9483:SENP8
uniprot id: F6WYT0
names: Similarity
messages: Belongs to the peptidase C48 family.

9483:MYADML2
gene id: 9483:MYADML2
uniprot id: A0A2R8MAB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9483:LOC100408457
gene id: 9483:LOC100408457
uniprot id: A8CYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:LOC100389983
gene id: 9483:LOC100389983
uniprot id: F7INI1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:FOXN2
gene id: 9483:FOXN2
uniprot id: U3EET7
names: Subcellular Location Annotation
messages: Nucleus

9483:MYF6
gene id: 9483:MYF6
uniprot id: A0A8I3X9W2
names: Subcellular Location Annotation
messages: Nucleus

9483:TLCD5
gene id: 9483:TLCD5
uniprot id: F7IGM9
names: Subcellular Location Annotation
messages: Membrane

9483:MON2
gene id: 9483:MON2
uniprot id: U3DXG9
names: Similarity
messages: Belongs to the MON2 family.

9483:ETV6
gene id: 9483:ETV6
uniprot id: U3FNJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:DIPK2B
gene id: 9483:DIPK2B
uniprot id: F7ISG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9483:NME4
gene id: 9483:NME4
uniprot id: F6S5S0
names: Similarity
messages: Belongs to the NDK family.

9483:ADAM17
gene id: 9483:ADAM17
uniprot id: U3CYN9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:HOXB1
gene id: 9483:HOXB1
uniprot id: F6X2V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9483:EIF4E
gene id: 9483:EIF4E
uniprot id: U3BQJ7
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9483:NMI
gene id: 9483:NMI
uniprot id: F7HL49
uniprot id: U3BI76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9483:SLC30A5
gene id: 9483:SLC30A5
uniprot id: U3EDJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9483:MRPS24
gene id: 9483:MRPS24
uniprot id: U3CV92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9483:GREM2
gene id: 9483:GREM2
uniprot id: F7IL92
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:APMAP
gene id: 9483:APMAP
uniprot id: F6S5S8
names: Similarity
messages: Belongs to the strictosidine synthase family.

9483:GABARAPL2
gene id: 9483:GABARAPL2
uniprot id: F7HV98
names: Similarity
messages: Belongs to the ATG8 family.

9483:FAM98C
gene id: 9483:FAM98C
uniprot id: F6YIR8
names: Similarity
messages: Belongs to the FAM98 family.

9483:CDA
gene id: 9483:CDA
uniprot id: A0A2R8MEI9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

9483:PCSK2
gene id: 9483:PCSK2
uniprot id: U3CJ12
uniprot id: U3FAE0
names: Similarity
messages: Belongs to the peptidase S8 family.

9483:LOC108589366
gene id: 9483:LOC108589366
uniprot id: A0A8I3X6J8
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9483:TIMM9
gene id: 9483:TIMM9
uniprot id: F7F0A5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9483:CITED1
gene id: 9483:CITED1
uniprot id: A0A8I3WMD9
uniprot id: F7CIL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9483:ENTPD7
gene id: 9483:ENTPD7
uniprot id: F7IHC4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9483:LOXL1
gene id: 9483:LOXL1
uniprot id: F6S0D4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9483:PDZK1IP1
gene id: 9483:PDZK1IP1
uniprot id: F7DUI4
names: Subcellular Location Annotation
messages: Membrane

9483:GALNT1
gene id: 9483:GALNT1
uniprot id: U3BYF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:SLC25A45
gene id: 9483:SLC25A45
uniprot id: A0A5F4VVU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:GRIA4
gene id: 9483:GRIA4
uniprot id: A0A2R8P4U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9483:TTI2
gene id: 9483:TTI2
uniprot id: F7HQT3
names: Similarity
messages: Belongs to the TTI2 family.

9483:NEXMIF
gene id: 9483:NEXMIF
uniprot id: F7H8J4
names: Subcellular Location Annotation
messages: Nucleus

9483:HEATR1
gene id: 9483:HEATR1
uniprot id: U3CG93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9483:CREM
gene id: 9483:CREM
uniprot id: U3DB32
names: Subcellular Location Annotation
messages: Nucleus

9483:GNMT
gene id: 9483:GNMT
uniprot id: F7I607
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9483:POGLUT3
gene id: 9483:POGLUT3
uniprot id: F7H5J1
names: Similarity
messages: Belongs to the KDELC family.

9483:NME2
gene id: 9483:NME2
uniprot id: F6YGJ2
names: Similarity
messages: Belongs to the NDK family.

9483:FLCN
gene id: 9483:FLCN
uniprot id: U3DLI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9483:GPR4
gene id: 9483:GPR4
uniprot id: A0A2R8NAC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LEF1
gene id: 9483:LEF1
uniprot id: F7G9Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9483:PRTFDC1
gene id: 9483:PRTFDC1
uniprot id: U3EZ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9483:SGK1
gene id: 9483:SGK1
uniprot id: F7I0Y6
uniprot id: U3DA47
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:ARPC2
gene id: 9483:ARPC2
uniprot id: U3CJ54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9483:ITGA6
gene id: 9483:ITGA6
uniprot id: U3FDN1
uniprot id: U3FHX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9483:MAS1
gene id: 9483:MAS1
uniprot id: U3CF76
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:MTNR1A
gene id: 9483:MTNR1A
uniprot id: F6VX53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9483:CCL24
gene id: 9483:CCL24
uniprot id: A0A8I3WWJ4
names: Subcellular Location Annotation
messages: Secreted

9483:FMC1
gene id: 9483:FMC1
uniprot id: U3FMF8
names: Similarity
messages: Belongs to the FMC1 family.

9483:ELOVL1
gene id: 9483:ELOVL1
uniprot id: U3D550
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9483:GLUD1
gene id: 9483:GLUD1
uniprot id: U3C0I9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

9483:HSD17B1
gene id: 9483:HSD17B1
uniprot id: Q9GME2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Favors the reduction of estrogens and androgens. Uses preferentially NADH.

9483:CUTC
gene id: 9483:CUTC
uniprot id: U3EID7
names: Similarity
messages: Belongs to the CutC family.

9483:CDCA5
gene id: 9483:CDCA5
uniprot id: F7BP81
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9483:ANAPC13
gene id: 9483:ANAPC13
uniprot id: F7I106
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9483:FEZ1
gene id: 9483:FEZ1
uniprot id: A0A2R8M9E2
names: Similarity
messages: Belongs to the zygin family.

9483:TFB2M
gene id: 9483:TFB2M
uniprot id: A0A8I4A234
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CLTC
gene id: 9483:CLTC
uniprot id: U3D6K0
uniprot id: U3F8X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9483:NDUFB4
gene id: 9483:NDUFB4
uniprot id: F7HJN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:SENP1
gene id: 9483:SENP1
uniprot id: U3FPX9
names: Similarity
messages: Belongs to the peptidase C48 family.

9483:ASB8
gene id: 9483:ASB8
uniprot id: A0A2R8MBP3
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9483:MND1
gene id: 9483:MND1
uniprot id: F7HA07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

9483:TMEM167B
gene id: 9483:TMEM167B
uniprot id: F6UZC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:PTPN18
gene id: 9483:PTPN18
uniprot id: U3BL66
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

9483:RBM8A
gene id: 9483:RBM8A
uniprot id: F7DRZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9483:CAVIN2
gene id: 9483:CAVIN2
uniprot id: F7F4U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9483:GLMP
gene id: 9483:GLMP
uniprot id: A0A8I3XF97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9483:ATOSB
gene id: 9483:ATOSB
uniprot id: F6UDZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9483:FBXO48
gene id: 9483:FBXO48
uniprot id: F7GBR8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9483:VAMP2
gene id: 9483:VAMP2
uniprot id: A0A2R8P2U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9483:MGAT2
gene id: 9483:MGAT2
uniprot id: U3DIB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

9483:TGFBR1
gene id: 9483:TGFBR1
uniprot id: F7H653
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9483:LOC100408493
gene id: 9483:LOC100408493
uniprot id: F6WV13
names: Similarity
messages: Belongs to the LCE family.

9483:PARL
gene id: 9483:PARL
uniprot id: U3BKB5
uniprot id: U3C4X5
names: Subcellular Location Annotation
messages: Membrane

9483:LOC100406761
gene id: 9483:LOC100406761
uniprot id: A0A8I4A2X5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9483:NCBP1
gene id: 9483:NCBP1
uniprot id: A0A2R8MCM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9483:COQ6
gene id: 9483:COQ6
uniprot id: U3BRU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

9483:PSMB7
gene id: 9483:PSMB7
uniprot id: F7DRQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9483:LPXN
gene id: 9483:LPXN
uniprot id: A0A2R8MHV6
uniprot id: U3FPD0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).
messages: focal adhesion
messages: perinuclear region
messages: podosome

9483:NME7
gene id: 9483:NME7
uniprot id: U3E823
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9483:SLC24A2
gene id: 9483:SLC24A2
uniprot id: U3DDA8
uniprot id: U3E340
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9483:SRP68
gene id: 9483:SRP68
uniprot id: U3D7E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9483:HMGN5
gene id: 9483:HMGN5
uniprot id: A0A5F4WAP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9483:HMGN1
gene id: 9483:HMGN1
uniprot id: F7II06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9483:MRPL14
gene id: 9483:MRPL14
uniprot id: U3ECB1
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9483:SNX13
gene id: 9483:SNX13
uniprot id: F6Z6T9
uniprot id: U3FK03
names: Similarity
messages: Belongs to the sorting nexin family.

9483:HLF
gene id: 9483:HLF
uniprot id: A0A8I3WL88
uniprot id: F7FH72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9483:YPEL4
gene id: 9483:YPEL4
uniprot id: F7CLM8
names: Similarity
messages: Belongs to the yippee family.

9483:LOC100894898
gene id: 9483:LOC100894898
uniprot id: A0A2R8MPE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9483:SPTBN2
gene id: 9483:SPTBN2
uniprot id: U3DCT7
names: Similarity
messages: Belongs to the spectrin family.

9483:GSX2
gene id: 9483:GSX2
uniprot id: F6UMR1
names: Subcellular Location Annotation
messages: Nucleus

9483:APOM
gene id: 9483:APOM
uniprot id: A0A5F4W6R8
uniprot id: F7HY96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9483:NADSYN1
gene id: 9483:NADSYN1
uniprot id: U3D6C7
names: Similarity
names: Subunit
messages: Homohexamer.
messages: In the C-terminal section; belongs to the NAD synthetase family.

9483:MITF
gene id: 9483:MITF
uniprot id: A0A5K1UW48
uniprot id: F6S413
uniprot id: F7FA74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9483:FUT1
gene id: 9483:FUT1
uniprot id: U3E6W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a.
messages: Golgi stack membrane
messages: Membrane

9483:MIXL1
gene id: 9483:MIXL1
uniprot id: F7I8Q6
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100410615
gene id: 9483:LOC100410615
uniprot id: F7H5T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PCYT1A
gene id: 9483:PCYT1A
uniprot id: U3DKF2
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9483:SOSTDC1
gene id: 9483:SOSTDC1
uniprot id: F6USQ7
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:DDIT4L
gene id: 9483:DDIT4L
uniprot id: F6UJJ8
names: Similarity
messages: Belongs to the DDIT4 family.

9483:NXPH3
gene id: 9483:NXPH3
uniprot id: F7CES0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9483:FOXS1
gene id: 9483:FOXS1
uniprot id: F7ELQ3
names: Subcellular Location Annotation
messages: Nucleus

9483:UCHL1
gene id: 9483:UCHL1
uniprot id: U3FKC1
names: Similarity
messages: Belongs to the peptidase C12 family.

9483:OSBPL6
gene id: 9483:OSBPL6
uniprot id: F7IH05
names: Similarity
messages: Belongs to the OSBP family.

9483:GSKIP
gene id: 9483:GSKIP
uniprot id: U3CU76
names: Similarity
messages: Belongs to the GSKIP family.

9483:FAM8A1
gene id: 9483:FAM8A1
uniprot id: U3BGC6
names: Subcellular Location Annotation
messages: Membrane

9483:ERBB2
gene id: 9483:ERBB2
uniprot id: F7CBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9483:MAP3K14
gene id: 9483:MAP3K14
uniprot id: A0A8I4A3R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9483:CXCR4
gene id: 9483:CXCR4
uniprot id: Q8HZU1
uniprot id: U3FG72
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
messages: O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.
messages: Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation.
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).
messages: Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.
messages: Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S.

9483:ADTRP
gene id: 9483:ADTRP
uniprot id: F7DN37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9483:FEN1
gene id: 9483:FEN1
uniprot id: F7GXF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Mitochondrion
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9483:ASXL1
gene id: 9483:ASXL1
uniprot id: U3CD57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9483:FMO2
gene id: 9483:FMO2
uniprot id: A0A221I0G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9483:IL33
gene id: 9483:IL33
uniprot id: A0A2R8PF76
uniprot id: F6PUA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9483:RGS3
gene id: 9483:RGS3
uniprot id: F6RBS6
names: Subcellular Location Annotation
messages: Cytoplasm

9483:DTX3L
gene id: 9483:DTX3L
uniprot id: U3CUK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9483:BDH1
gene id: 9483:BDH1
uniprot id: U3C2M8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:CASTOR1
gene id: 9483:CASTOR1
uniprot id: F6TTG3
uniprot id: U3E167
names: Similarity
messages: Belongs to the GATS family.

9483:KCNK2
gene id: 9483:KCNK2
uniprot id: A0A8I3WU10
uniprot id: F6UI26
uniprot id: U3EGJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9483:DARS2
gene id: 9483:DARS2
uniprot id: F7HYM1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9483:ADRA1D
gene id: 9483:ADRA1D
uniprot id: F7CTX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9483:TSPO2
gene id: 9483:TSPO2
uniprot id: F6R8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9483:SLC35A2
gene id: 9483:SLC35A2
uniprot id: A0A8I3X9V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:ENTPD8
gene id: 9483:ENTPD8
uniprot id: A0A2R8PDR7
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9483:CAJA-DRA
gene id: 9483:CAJA-DRA
uniprot id: U3E867
names: Similarity
messages: Belongs to the MHC class II family.

9483:GNAQ
gene id: 9483:GNAQ
uniprot id: F7IC22
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9483:HOXB7
gene id: 9483:HOXB7
uniprot id: F7AVK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9483:LRP6
gene id: 9483:LRP6
uniprot id: A0A8I4A282
uniprot id: U3DLY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:POLR3G
gene id: 9483:POLR3G
uniprot id: F6YUR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

9483:FAM174C
gene id: 9483:FAM174C
uniprot id: U3FFU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9483:AQP4
gene id: 9483:AQP4
uniprot id: F7I6W3
uniprot id: U3E3H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:SMU1
gene id: 9483:SMU1
uniprot id: F7HXH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9483:LOC100410631
gene id: 9483:LOC100410631
uniprot id: F7I360
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9483:SLC4A8
gene id: 9483:SLC4A8
uniprot id: F7EQN7
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9483:TATDN3
gene id: 9483:TATDN3
uniprot id: F7IRW0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9483:TUSC3
gene id: 9483:TUSC3
uniprot id: F6T1G7
uniprot id: F7C9S5
uniprot id: U3BNG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:FGD2
gene id: 9483:FGD2
uniprot id: F7HHG0
uniprot id: F7HHJ2
names: Subcellular Location Annotation
messages: cytoskeleton

9483:GTF3C5
gene id: 9483:GTF3C5
uniprot id: U3ESU6
names: Subcellular Location Annotation
messages: Nucleus

9483:WARS1
gene id: 9483:WARS1
uniprot id: A0A8J8YCI7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9483:RUNX1
gene id: 9483:RUNX1
uniprot id: U3FHT7
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9483:ACTC1
gene id: 9483:ACTC1
uniprot id: A0A8I4A3C0
names: Similarity
messages: Belongs to the actin family.

9483:LOC103788988
gene id: 9483:LOC103788988
uniprot id: A0A8I3VYN9
names: Similarity
messages: Belongs to the LCE family.

9483:PELI1
gene id: 9483:PELI1
uniprot id: U3F2B6
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9483:MTERF3
gene id: 9483:MTERF3
uniprot id: U3EUI8
names: Similarity
messages: Belongs to the mTERF family.

9483:SLC37A4
gene id: 9483:SLC37A4
uniprot id: U3DRQ5
uniprot id: U3E234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9483:DEFB124
gene id: 9483:DEFB124
uniprot id: A0A5F4W2I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:STX11
gene id: 9483:STX11
uniprot id: A0A8J8Y9W3
names: Similarity
messages: Belongs to the syntaxin family.

9483:GABARAPL1
gene id: 9483:GABARAPL1
uniprot id: F7HVH6
names: Similarity
messages: Belongs to the ATG8 family.

9483:ARL3
gene id: 9483:ARL3
uniprot id: F6SUZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9483:BOK
gene id: 9483:BOK
uniprot id: U3CXP7
names: Similarity
messages: Belongs to the Bcl-2 family.

9483:C1S
gene id: 9483:C1S
uniprot id: U3BUP2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOC108587672
gene id: 9483:LOC108587672
uniprot id: F7I0E1
names: Similarity
messages: Belongs to the NAC-beta family.

9483:LOC103788005
gene id: 9483:LOC103788005
uniprot id: A0A8I3WH84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9483:HFE
gene id: 9483:HFE
uniprot id: F7GRH8
names: Similarity
messages: Belongs to the MHC class I family.

9483:BTC
gene id: 9483:BTC
uniprot id: A0A5F4VVZ7
uniprot id: A0A8I3WV70
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PWP2
gene id: 9483:PWP2
uniprot id: A0A5F4W2D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9483:NT5E
gene id: 9483:NT5E
uniprot id: U3CHA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9483:COG8
gene id: 9483:COG8
uniprot id: U3DHB4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

9483:ABI3
gene id: 9483:ABI3
uniprot id: F6VGL5
names: Similarity
messages: Belongs to the ABI family.

9483:MED11
gene id: 9483:MED11
uniprot id: F6UN01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:NUP85
gene id: 9483:NUP85
uniprot id: F7IG61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9483:GINS3
gene id: 9483:GINS3
uniprot id: F6T6J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9483:SCD5
gene id: 9483:SCD5
uniprot id: F7HMC4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9483:PPP6C
gene id: 9483:PPP6C
uniprot id: U3EMC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9483:TAF2
gene id: 9483:TAF2
uniprot id: A0A8I3WW93
uniprot id: U3F1J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

9483:FOXA1
gene id: 9483:FOXA1
uniprot id: U3BW21
names: Subcellular Location Annotation
messages: Nucleus

9483:ACSL1
gene id: 9483:ACSL1
uniprot id: F7C1E6
uniprot id: Q9GLP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9483:MED28
gene id: 9483:MED28
uniprot id: U3DSH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9483:ELAC1
gene id: 9483:ELAC1
uniprot id: U3DIH8
names: Subunit
messages: Homodimer.

9483:RAX
gene id: 9483:RAX
uniprot id: F7DZ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9483:CHST6
gene id: 9483:CHST6
uniprot id: F7ITB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9483:LOC108592192
gene id: 9483:LOC108592192
uniprot id: F7H244
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9483:ACTR2
gene id: 9483:ACTR2
uniprot id: F7EI23
uniprot id: U3EIC6
names: Similarity
messages: Belongs to the actin family.

9483:GJB2
gene id: 9483:GJB2
uniprot id: F7HZW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:KHDC3L
gene id: 9483:KHDC3L
uniprot id: U3DJS3
names: Similarity
messages: Belongs to the KHDC1 family.

9483:LOC100390575
gene id: 9483:LOC100390575
uniprot id: A0A2R8MCW0
names: Similarity
messages: Belongs to the PRR23 family.

9483:KCTD20
gene id: 9483:KCTD20
uniprot id: F7IJE3
names: Subcellular Location Annotation
messages: Cytoplasm

9483:CDK10
gene id: 9483:CDK10
uniprot id: F7C8F5
uniprot id: U3CHA2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:LOC100406834
gene id: 9483:LOC100406834
uniprot id: H9KXU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SLC25A23
gene id: 9483:SLC25A23
uniprot id: U3DCE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:MOGAT1
gene id: 9483:MOGAT1
uniprot id: F7ID79
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TMA16
gene id: 9483:TMA16
uniprot id: U3CI81
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9483:ANXA3
gene id: 9483:ANXA3
uniprot id: F7H4N2
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9483:C4H6orf58
gene id: 9483:C4H6orf58
uniprot id: A0A8I3W6B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

9483:LSM3
gene id: 9483:LSM3
uniprot id: F7ICR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9483:HSD17B7
gene id: 9483:HSD17B7
uniprot id: U3EMT5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9483:GOLT1A
gene id: 9483:GOLT1A
uniprot id: F7IRX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9483:LOC100411198
gene id: 9483:LOC100411198
uniprot id: Q9N2D2
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Expressed in adult, not neonate-specific as in other organisms.
messages: Hydrolyzes a variety of proteins.
messages: Inhibited by pepstatin.
messages: Monomer.

9483:PIK3R2
gene id: 9483:PIK3R2
uniprot id: F6ZCI2
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9483:ARF5
gene id: 9483:ARF5
uniprot id: F7HBX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9483:CEPT1
gene id: 9483:CEPT1
uniprot id: F7G2A6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9483:LOC100389231
gene id: 9483:LOC100389231
uniprot id: A0A8I3WIG8
uniprot id: F7IA32
names: Similarity
messages: Belongs to the MIF family.

9483:LOC100387786
gene id: 9483:LOC100387786
uniprot id: F7FTC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9483:ABCF3
gene id: 9483:ABCF3
uniprot id: F7D4K0
names: Subunit
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

9483:FAIM2
gene id: 9483:FAIM2
uniprot id: F7GY56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9483:EPS8
gene id: 9483:EPS8
uniprot id: U3CNU6
names: Similarity
messages: Belongs to the EPS8 family.

9483:ACSL6
gene id: 9483:ACSL6
uniprot id: U3D011
uniprot id: U3DNT5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

9483:PSMD13
gene id: 9483:PSMD13
uniprot id: U3C564
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9483:PNP
gene id: 9483:PNP
uniprot id: F7IC61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9483:SRF
gene id: 9483:SRF
uniprot id: F7HCP4
names: Subcellular Location Annotation
messages: Nucleus

9483:NUDT5
gene id: 9483:NUDT5
uniprot id: U3DDE9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9483:RAB4A
gene id: 9483:RAB4A
uniprot id: A0A5F4VSH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9483:LOC100390461
gene id: 9483:LOC100390461
uniprot id: F6X0G4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:LOC100410089
gene id: 9483:LOC100410089
uniprot id: A0A2R8M6K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:CHCHD4
gene id: 9483:CHCHD4
uniprot id: U3EA41
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

9483:ACHE
gene id: 9483:ACHE
uniprot id: U3EB48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9483:TXNL4A
gene id: 9483:TXNL4A
uniprot id: A0A8I4A2K8
uniprot id: U3CQA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9483:RBM46
gene id: 9483:RBM46
uniprot id: F7CWB1
names: Subcellular Location Annotation
messages: Cytoplasm

9483:GCNT3
gene id: 9483:GCNT3
uniprot id: F7FUY3
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9483:APPL1
gene id: 9483:APPL1
uniprot id: F7FXM1
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9483:RPS28
gene id: 9483:RPS28
uniprot id: F6WXM1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

9483:CCL7
gene id: 9483:CCL7
uniprot id: A0A5F4WJQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:CCNG2
gene id: 9483:CCNG2
uniprot id: F6VUX7
names: Similarity
messages: Belongs to the cyclin family.

9483:NFRKB
gene id: 9483:NFRKB
uniprot id: A0A8I3W1H0
names: Subcellular Location Annotation
messages: Nucleus

9483:SEC24D
gene id: 9483:SEC24D
uniprot id: U3CPH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9483:EEF2
gene id: 9483:EEF2
uniprot id: A0SXL6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Binds to 80S ribosomes. Actively translating ribosomes show mutually exclusive binding of eIF5a (EIF5A or EIF5A2) and EEF2/eEF2. Interacts with SERBP1; interaction sequesters EEF2/eEF2 at the A-site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation (By similarity). Interacts with HABP4; interaction takes place at the A-site of hibernating ribosomes and promotes ribosome stabilization (By similarity). Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9. Interacts with RBPMS2 (By similarity).
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm
messages: Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine (By similarity).
messages: ISGylated.
messages: Nucleus
messages: Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
messages: Proteolytically processed at two sites following phosphorylation by CSK.
messages: SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage.

9483:RPL6
gene id: 9483:RPL6
uniprot id: A0A8I3WR85
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9483:HCFC2
gene id: 9483:HCFC2
uniprot id: F7HUQ6
names: Subcellular Location Annotation
messages: Nucleus

9483:BAK1
gene id: 9483:BAK1
uniprot id: F7ICC2
names: Similarity
messages: Belongs to the Bcl-2 family.

9483:PTGDR
gene id: 9483:PTGDR
uniprot id: A0A2R8NFM2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:MAPK6
gene id: 9483:MAPK6
uniprot id: U3DTN7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9483:GREM1
gene id: 9483:GREM1
uniprot id: F6R9I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9483:PLAC8L1
gene id: 9483:PLAC8L1
uniprot id: F7DT58
names: Similarity
messages: Belongs to the cornifelin family.

9483:PLK2
gene id: 9483:PLK2
uniprot id: F7HJL7
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9483:GTF2H3
gene id: 9483:GTF2H3
uniprot id: U3CMZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9483:SPRYD3
gene id: 9483:SPRYD3
uniprot id: U3CLM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:LOC100399393
gene id: 9483:LOC100399393
uniprot id: F7IRG6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9483:ARL2BP
gene id: 9483:ARL2BP
uniprot id: F7C9D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9483:LOC100404838
gene id: 9483:LOC100404838
uniprot id: A0A2R8PER2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:PCBD2
gene id: 9483:PCBD2
uniprot id: F7HYZ8
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9483:TMEM161A
gene id: 9483:TMEM161A
uniprot id: U3FUY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9483:PTDSS2
gene id: 9483:PTDSS2
uniprot id: F7IDD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:SQSTM1
gene id: 9483:SQSTM1
uniprot id: F7G7S9
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9483:SPTY2D1
gene id: 9483:SPTY2D1
uniprot id: F6RDJ0
names: Similarity
messages: Belongs to the SPT2 family.

9483:SH3BP5L
gene id: 9483:SH3BP5L
uniprot id: F7IK25
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9483:KCNH3
gene id: 9483:KCNH3
uniprot id: F7IQF7
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9483:EPHA4
gene id: 9483:EPHA4
uniprot id: U3EIW0
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9483:SCAMP2
gene id: 9483:SCAMP2
uniprot id: F6UFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9483:PXMP4
gene id: 9483:PXMP4
uniprot id: A0A8I3X939
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9483:TNF
gene id: 9483:TNF
uniprot id: Q19LH4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity).
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9483:SLC18B1
gene id: 9483:SLC18B1
uniprot id: A0A8I3W283
names: Subcellular Location Annotation
messages: Membrane

9483:ANXA2
gene id: 9483:ANXA2
uniprot id: A0A8I4A3A1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

9483:RDH12
gene id: 9483:RDH12
uniprot id: U3DUP1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:NFE2L1
gene id: 9483:NFE2L1
uniprot id: U3FVE9
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9483:CD40
gene id: 9483:CD40
uniprot id: Q3LRP1
uniprot id: U3C9Y9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).
messages: Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).

9483:PARP15
gene id: 9483:PARP15
uniprot id: F7IL00
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:CLIC1
gene id: 9483:CLIC1
uniprot id: F7IM19
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9483:LIPG
gene id: 9483:LIPG
uniprot id: F6V0B4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:JPT1
gene id: 9483:JPT1
uniprot id: U3B1Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9483:GABRA1
gene id: 9483:GABRA1
uniprot id: F7GM19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:PDE4D
gene id: 9483:PDE4D
uniprot id: F6VBV7
uniprot id: F7AQU4
uniprot id: F7B975
uniprot id: U3BNV5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:CDC20
gene id: 9483:CDC20
uniprot id: F7G9N7
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9483:FBN1
gene id: 9483:FBN1
uniprot id: F7ALZ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:NDFIP1
gene id: 9483:NDFIP1
uniprot id: U3FXR9
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9483:LOC100411007
gene id: 9483:LOC100411007
uniprot id: U3FPJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9483:MTM1
gene id: 9483:MTM1
uniprot id: U3BTU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9483:GFUS
gene id: 9483:GFUS
uniprot id: U3C1T5
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9483:RPAP2
gene id: 9483:RPAP2
uniprot id: A0A8I3W2L5
uniprot id: F7EDE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

9483:AADACL3
gene id: 9483:AADACL3
uniprot id: F6X991
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9483:GATAD1
gene id: 9483:GATAD1
uniprot id: F7AXR7
names: Subcellular Location Annotation
messages: Nucleus

9483:GRB10
gene id: 9483:GRB10
uniprot id: A0A2R8N0W5
uniprot id: A0A5K1VG16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9483:CORO1A
gene id: 9483:CORO1A
uniprot id: U3FGQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

9483:NR3C1
gene id: 9483:NR3C1
uniprot id: A0A6D5HP83
uniprot id: Q6XLJ0
uniprot id: U3EM87
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required.
messages: Cytoplasm
messages: Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1 and TGFB1I1. Interacts with NCOA1. Interacts with NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1. Interacts with CLOCK, CRY1 and CRY2 in a ligand-dependent fashion. Interacts with CIART. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. Interacts with GRIP1. Interacts with NR4A3 (via nuclear receptor DNA-binding domain), represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE). Directly interacts with PNRC2 to attract and form a complex with UPF1 and DCP1A; the interaction leads to rapid mRNA degradation. Interacts with GSK3B. Interacts with FNIP1 and FNIP2. Interacts (via C-terminus) with HNRNPU (via C-terminus). Interacts with MCM3AP (By similarity). Interacts (via domain NR LBD) with HSP90AA1 and HSP90AB1 (By similarity). In the absence of hormonal ligand, interacts with TACC1 (By similarity). Interacts (via NR LBD domain) with ZNF764 (via KRAB domain); the interaction regula…
messages: Increased proteasome-mediated degradation in response to glucocorticoids.
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Phosphorylation at Ser-211 increases transcriptional activity. Phosphorylation at Ser-203, Ser-226 and Ser-404 decreases signaling capacity. Phosphorylation at Ser-404 may protect from glucocorticoid-induced apoptosis. Phosphorylation at Ser-203 and Ser-211 is not required in regulation of chromosome segregation. May be dephosphorylated by PPP5C, attenuates NR3C1 action.
messages: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.
messages: Sumoylation at Lys-277 and Lys-293 negatively regulates its transcriptional activity. Sumoylation at Lys-703 positively regulates its transcriptional activity in the presence of RWDD3. Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-703 is critical for the stimulatory effect of RWDD3 on its transcriptional activity. Heat shock increases sumoylation in a RWDD3-dependent manner.
messages: Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
messages: Within the infant and adult hippocampal formation, highest expression observed in the DG granule cell layer with moderate levels in the DG hilus, the CA2-CA4 pyramidal cell layer and the proximal part of the CA1 pyramidal cell layer. Moderate to high expression levels found in the presubiculum and in its' superficial layers. Weak but specific expression detected throughout the entire corticle mantle. In the amygdala, moderate levels were detected in the lateral, central and medial nuclei. Moderate expression levels were present in the PVNh alongside the third ventricle.
messages: centrosome
messages: spindle

9483:LALBA
gene id: 9483:LALBA
uniprot id: F7I977
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9483:LOC100400731
gene id: 9483:LOC100400731
uniprot id: A0A5F4WDC2
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9483:RPF2
gene id: 9483:RPF2
uniprot id: U3DYQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

9483:ADGRF5
gene id: 9483:ADGRF5
uniprot id: U3DDZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9483:DHODH
gene id: 9483:DHODH
uniprot id: F7GU02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9483:GPR137C
gene id: 9483:GPR137C
uniprot id: F6UCN2
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9483:SCAMP3
gene id: 9483:SCAMP3
uniprot id: F7GGH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9483:DUSP13
gene id: 9483:DUSP13
uniprot id: A0A5F4WAP2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9483:CHRNE
gene id: 9483:CHRNE
uniprot id: F6QPL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:ATG3
gene id: 9483:ATG3
uniprot id: U3BCW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG3 family.
messages: Cytoplasm

9483:LOC100415579
gene id: 9483:LOC100415579
uniprot id: F6V6V9
names: Similarity
messages: Belongs to the GAGE family.

9483:HABP4
gene id: 9483:HABP4
uniprot id: A0A5F4WJU0
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

9483:HHIP
gene id: 9483:HHIP
uniprot id: F6UZU3
uniprot id: U3FQI0
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:RSPO1
gene id: 9483:RSPO1
uniprot id: F7H9I5
names: Similarity
messages: Belongs to the R-spondin family.

9483:BTBD3
gene id: 9483:BTBD3
uniprot id: F7ASZ0
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity).
messages: Nucleus
messages: Strongly expressed in the primary visual cortex.
messages: cytosol

9483:PGLS
gene id: 9483:PGLS
uniprot id: F6ZGY9
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

9483:NBN
gene id: 9483:NBN
uniprot id: U3EK58
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
messages: Component of the MRN complex.
messages: Nucleus
messages: telomere

9483:GIMD1
gene id: 9483:GIMD1
uniprot id: F7IRN2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9483:GNGT2
gene id: 9483:GNGT2
uniprot id: F6UVS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:SNX17
gene id: 9483:SNX17
uniprot id: F7IBA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9483:NUP35
gene id: 9483:NUP35
uniprot id: U3EEJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9483:HSPB1
gene id: 9483:HSPB1
uniprot id: F7I2I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9483:PPP2CB
gene id: 9483:PPP2CB
uniprot id: F6XZ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9483:GPX8
gene id: 9483:GPX8
uniprot id: F7ISV1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9483:RPL19
gene id: 9483:RPL19
uniprot id: F7EZL4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9483:TMEM218
gene id: 9483:TMEM218
uniprot id: F6X530
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9483:DNM3
gene id: 9483:DNM3
uniprot id: F7HY82
uniprot id: U3EHX9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9483:ENTPD4
gene id: 9483:ENTPD4
uniprot id: A0A8J8XFF4
uniprot id: F6YYY9
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9483:CLCA4
gene id: 9483:CLCA4
uniprot id: F7CCL6
names: Similarity
messages: Belongs to the CLCR family.

9483:TMEM161B
gene id: 9483:TMEM161B
uniprot id: U3FR05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9483:CD14
gene id: 9483:CD14
uniprot id: F7B9N7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

9483:ZRANB2
gene id: 9483:ZRANB2
uniprot id: U3E0L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9483:BAMBI
gene id: 9483:BAMBI
uniprot id: F7GN88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9483:NSRP1
gene id: 9483:NSRP1
uniprot id: A0A8I3W236
uniprot id: F6YHK4
names: Similarity
messages: Belongs to the NSRP1 family.

9483:ROMO1
gene id: 9483:ROMO1
uniprot id: B0KWM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9483:ATOH7
gene id: 9483:ATOH7
uniprot id: A0A2R8NEN1
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

9483:PHOSPHO2
gene id: 9483:PHOSPHO2
uniprot id: F7HDN3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9483:CD3E
gene id: 9483:CD3E
uniprot id: Q3LRP4
names: Subcellular Location Annotation
messages: Membrane

9483:ELAPOR2
gene id: 9483:ELAPOR2
uniprot id: A0A8I3W3Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9483:CLDN10
gene id: 9483:CLDN10
uniprot id: U3DXA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:SEC61B
gene id: 9483:SEC61B
uniprot id: F7GQT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9483:LOC100396215
gene id: 9483:LOC100396215
uniprot id: F7IT65
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:KRT3
gene id: 9483:KRT3
uniprot id: L7N0W8
names: Similarity
messages: Belongs to the intermediate filament family.

9483:PARP9
gene id: 9483:PARP9
uniprot id: F7IBF8
uniprot id: U3DWP6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:PMCH
gene id: 9483:PMCH
uniprot id: U3E078
names: Similarity
messages: Belongs to the melanin-concentrating hormone family.

9483:RP2
gene id: 9483:RP2
uniprot id: F6ZU00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9483:CERS2
gene id: 9483:CERS2
uniprot id: U3F4E2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9483:CCDC85A
gene id: 9483:CCDC85A
uniprot id: A0A8I3W9K1
uniprot id: A0A8I3WLT9
uniprot id: F7I9W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9483:MTX2
gene id: 9483:MTX2
uniprot id: A0A5F4WBC3
uniprot id: U3ECU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:TAF1D
gene id: 9483:TAF1D
uniprot id: U3DRE0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9483:MYOG
gene id: 9483:MYOG
uniprot id: F7IP79
names: Subcellular Location Annotation
messages: Nucleus

9483:AMACR
gene id: 9483:AMACR
uniprot id: F7I3Q5
names: Similarity
messages: Belongs to the CoA-transferase III family.

9483:MPP2
gene id: 9483:MPP2
uniprot id: F6TFU1
names: Similarity
messages: Belongs to the MAGUK family.

9483:MAT1A
gene id: 9483:MAT1A
uniprot id: F7DH88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9483:LOC100402272
gene id: 9483:LOC100402272
uniprot id: A0A8I3WVE3
names: Similarity
messages: Belongs to the cystatin family.

9483:RPL3
gene id: 9483:RPL3
uniprot id: H9KX67
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9483:PPP6R1
gene id: 9483:PPP6R1
uniprot id: U3F4F5
names: Similarity
messages: Belongs to the SAPS family.

9483:EFNA1
gene id: 9483:EFNA1
uniprot id: F7AMD6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CTBS
gene id: 9483:CTBS
uniprot id: U3CS40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Lysosome

9483:PFN2
gene id: 9483:PFN2
uniprot id: U3BGM3
uniprot id: U3CT70
names: Similarity
messages: Belongs to the profilin family.

9483:ACOD1
gene id: 9483:ACOD1
uniprot id: F7FT06
names: Similarity
messages: Belongs to the PrpD family.

9483:VPS51
gene id: 9483:VPS51
uniprot id: F7CJS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Recycling endosome
messages: trans-Golgi network

9483:NACC2
gene id: 9483:NACC2
uniprot id: F6SRF1
names: Subcellular Location Annotation
messages: Nucleus

9483:TMEM50A
gene id: 9483:TMEM50A
uniprot id: F7IKB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9483:IL18
gene id: 9483:IL18
uniprot id: U3CWC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted

9483:ELL2
gene id: 9483:ELL2
uniprot id: A0A8I3WES2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9483:TXLNB
gene id: 9483:TXLNB
uniprot id: U3DG24
names: Similarity
messages: Belongs to the taxilin family.

9483:HSD17B11
gene id: 9483:HSD17B11
uniprot id: U3DLT9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:LOC100390849
gene id: 9483:LOC100390849
uniprot id: U3B2I5
names: Similarity
messages: Belongs to the GroES chaperonin family.

9483:SAR1B
gene id: 9483:SAR1B
uniprot id: F7IHI6
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9483:LOC100409753
gene id: 9483:LOC100409753
uniprot id: A0A2R8M4T8
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:OAT
gene id: 9483:OAT
uniprot id: U3FT89
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9483:DDX3Y
gene id: 9483:DDX3Y
uniprot id: B8YDY8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9483:LIX1L
gene id: 9483:LIX1L
uniprot id: U3B1X1
names: Similarity
messages: Belongs to the LIX1 family.

9483:AFG3L2
gene id: 9483:AFG3L2
uniprot id: F7I3C6
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9483:LONP2
gene id: 9483:LONP2
uniprot id: A0A5F4VY50
uniprot id: A0A5F4W7F5
uniprot id: U3CTR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
messages: Belongs to the peptidase S16 family.
messages: Interacts with PEX5. Interacts with TYSND1.
messages: Peroxisome matrix

9483:CALHM5
gene id: 9483:CALHM5
uniprot id: F7IPZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9483:CHMP1A
gene id: 9483:CHMP1A
uniprot id: A0A8I3XAU1
names: Similarity
messages: Belongs to the SNF7 family.

9483:SKP1
gene id: 9483:SKP1
uniprot id: U3CKA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.
messages: The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.

9483:ANKRD13C
gene id: 9483:ANKRD13C
uniprot id: U3F703
names: Subcellular Location Annotation
messages: Membrane

9483:LOC100409067
gene id: 9483:LOC100409067
uniprot id: A0A8I4A5K5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:DEGS1
gene id: 9483:DEGS1
uniprot id: F7IN61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:BEX4
gene id: 9483:BEX4
uniprot id: F7H6P0
names: Similarity
messages: Belongs to the BEX family.

9483:ARSI
gene id: 9483:ARSI
uniprot id: A0A2R8NEX2
names: Similarity
messages: Belongs to the sulfatase family.

9483:TNFSF10
gene id: 9483:TNFSF10
uniprot id: F7E747
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9483:ELP4
gene id: 9483:ELP4
uniprot id: F7IDJ9
uniprot id: U3C5B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

9483:AHSA1
gene id: 9483:AHSA1
uniprot id: A0A2R8N8T2
names: Similarity
messages: Belongs to the AHA1 family.

9483:SERF1A
gene id: 9483:SERF1A
uniprot id: F6SEZ1
names: Similarity
messages: Belongs to the SERF family.

9483:CDX4
gene id: 9483:CDX4
uniprot id: H9KWU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9483:B3GALNT1
gene id: 9483:B3GALNT1
uniprot id: F6XVE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:ANP32E
gene id: 9483:ANP32E
uniprot id: F7HKP3
uniprot id: F7IR97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9483:IQCD
gene id: 9483:IQCD
uniprot id: F7DQE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9483:L3MBTL3
gene id: 9483:L3MBTL3
uniprot id: F7I9N0
uniprot id: U3D1Y4
names: Subcellular Location Annotation
messages: Nucleus

9483:SLC35D1
gene id: 9483:SLC35D1
uniprot id: F7HHN3
names: Subcellular Location Annotation
messages: Membrane

9483:GNS
gene id: 9483:GNS
uniprot id: F7ENH2
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9483:SPADH
gene id: 9483:SPADH
uniprot id: A0A5F4W1L2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:NAF1
gene id: 9483:NAF1
uniprot id: A0A8I3WD50
uniprot id: U3FIR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

9483:ST3GAL3
gene id: 9483:ST3GAL3
uniprot id: U3FXU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:HIGD2A
gene id: 9483:HIGD2A
uniprot id: F7IAW2
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9483:KIF3B
gene id: 9483:KIF3B
uniprot id: F7IBN6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:MGAT1
gene id: 9483:MGAT1
uniprot id: F7I3E4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9483:KDELR3
gene id: 9483:KDELR3
uniprot id: U3CH29
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:LOC100391517
gene id: 9483:LOC100391517
uniprot id: F7DXB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

9483:RBX1
gene id: 9483:RBX1
uniprot id: F7IAL6
names: Similarity
messages: Belongs to the RING-box family.

9483:VPS29
gene id: 9483:VPS29
uniprot id: F7HLW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9483:EEF1A1
gene id: 9483:EEF1A1
uniprot id: A0A8I3VX86
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9483:NPRL3
gene id: 9483:NPRL3
uniprot id: B0VX74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

9483:PDCD11
gene id: 9483:PDCD11
uniprot id: A0A5F4VWX1
uniprot id: F6R7C7
names: Subcellular Location Annotation
messages: nucleolus

9483:SLC30A6
gene id: 9483:SLC30A6
uniprot id: A0A8I3WIB8
uniprot id: F7ICS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9483:CSNK1G1
gene id: 9483:CSNK1G1
uniprot id: A0A2R8MI70
uniprot id: A0A2R8MT47
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9483:LOC100390879
gene id: 9483:LOC100390879
uniprot id: F7F510
uniprot id: U3CAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9483:RPS11
gene id: 9483:RPS11
uniprot id: F7EY42
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9483:DCK
gene id: 9483:DCK
uniprot id: U3DGS6
names: Similarity
messages: Belongs to the DCK/DGK family.

9483:NIPA2
gene id: 9483:NIPA2
uniprot id: F7DQD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9483:NEFM
gene id: 9483:NEFM
uniprot id: A0A8I3WVA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon

9483:LOC100894890
gene id: 9483:LOC100894890
uniprot id: A0A8I3WJ75
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9483:MRS2
gene id: 9483:MRS2
uniprot id: U3EQV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

9483:CCDC25
gene id: 9483:CCDC25
uniprot id: A0A5F4W7J6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9483:LOC100410892
gene id: 9483:LOC100410892
uniprot id: B0KWQ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM1 family.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
messages: Cytoplasm
messages: Nucleus
messages: The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.

9483:PDK3
gene id: 9483:PDK3
uniprot id: U3DT63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9483:SEMA3E
gene id: 9483:SEMA3E
uniprot id: F7F565
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PIWIL1
gene id: 9483:PIWIL1
uniprot id: F7GRR2
names: Similarity
messages: Belongs to the argonaute family.

9483:MAPK1
gene id: 9483:MAPK1
uniprot id: F7AKA7
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola
messages: focal adhesion

9483:LOC100895825
gene id: 9483:LOC100895825
uniprot id: F7H5R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:POGLUT2
gene id: 9483:POGLUT2
uniprot id: F6ZGF8
names: Similarity
messages: Belongs to the KDELC family.

9483:CLCF1
gene id: 9483:CLCF1
uniprot id: A0A2R8MWL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9483:OR4C11
gene id: 9483:OR4C11
uniprot id: A0A8I3WNC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC100397481
gene id: 9483:LOC100397481
uniprot id: A0A2R8MZU2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

9483:TMEM41A
gene id: 9483:TMEM41A
uniprot id: A0A2R8PDW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9483:MAP3K8
gene id: 9483:MAP3K8
uniprot id: F7FA86
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9483:HCN3
gene id: 9483:HCN3
uniprot id: F7ELT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9483:SGCB
gene id: 9483:SGCB
uniprot id: F7IFJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

9483:SRPRB
gene id: 9483:SRPRB
uniprot id: A0A2R8PDK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:NOG
gene id: 9483:NOG
uniprot id: U3FU84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9483:CKM
gene id: 9483:CKM
uniprot id: U3BQ10
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9483:PDE5A
gene id: 9483:PDE5A
uniprot id: A0A2R8M2M9
uniprot id: A0A8I3X5J8
uniprot id: F7HKP9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:HMX3
gene id: 9483:HMX3
uniprot id: A0A8I3XF10
names: Subcellular Location Annotation
messages: Nucleus

9483:PAXBP1
gene id: 9483:PAXBP1
uniprot id: B0VXG1
names: Similarity
messages: Belongs to the GCF family.

9483:SIVA1
gene id: 9483:SIVA1
uniprot id: U3FLH3
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

9483:C13H18orf32
gene id: 9483:C13H18orf32
uniprot id: F7I248
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: Lipid droplet
messages: May activate the NF-kappa-B signaling pathway.

9483:SYK
gene id: 9483:SYK
uniprot id: U3BGC5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9483:CTNNA2
gene id: 9483:CTNNA2
uniprot id: A0A2R8MPZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9483:CALHM2
gene id: 9483:CALHM2
uniprot id: F6QN32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9483:CRBN
gene id: 9483:CRBN
uniprot id: U3FF41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9483:SLC30A9
gene id: 9483:SLC30A9
uniprot id: F7FLK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

9483:CXCL12
gene id: 9483:CXCL12
uniprot id: A0A8I3WCR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:PTGFR
gene id: 9483:PTGFR
uniprot id: A0A2R8MHU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:MCHR2
gene id: 9483:MCHR2
uniprot id: F7I268
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC103794843
gene id: 9483:LOC103794843
uniprot id: F7AHH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:MAPKAPK3
gene id: 9483:MAPKAPK3
uniprot id: U3CZ05
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:GNA13
gene id: 9483:GNA13
uniprot id: U3EV79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9483:TENT5B
gene id: 9483:TENT5B
uniprot id: U3D7K2
names: Similarity
messages: Belongs to the TENT family.

9483:ATPAF2
gene id: 9483:ATPAF2
uniprot id: U3D1C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9483:TTC19
gene id: 9483:TTC19
uniprot id: U3CQJ1
names: Similarity
messages: Belongs to the TTC19 family.

9483:HLCS
gene id: 9483:HLCS
uniprot id: U3BVA4
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9483:LOC103787296
gene id: 9483:LOC103787296
uniprot id: A0A1K0GY26
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.

9483:CIAPIN1
gene id: 9483:CIAPIN1
uniprot id: U3FXU7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9483:HSPA4
gene id: 9483:HSPA4
uniprot id: F7HTM4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9483:DPY19L4
gene id: 9483:DPY19L4
uniprot id: A0A8I3VVX1
uniprot id: F7GYW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9483:COX6A2
gene id: 9483:COX6A2
uniprot id: F6VFX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:ITFG1
gene id: 9483:ITFG1
uniprot id: U3DWU5
names: Similarity
messages: Belongs to the TIP family.

9483:ALPL
gene id: 9483:ALPL
uniprot id: D0ECS6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9483:PRIM1
gene id: 9483:PRIM1
uniprot id: F6Y809
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9483:SNAP23
gene id: 9483:SNAP23
uniprot id: H9KVX9
uniprot id: U3EQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9483:DYNLT4
gene id: 9483:DYNLT4
uniprot id: A0A5F4W1Y7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9483:MARCHF4
gene id: 9483:MARCHF4
uniprot id: U3DXK9
names: Subcellular Location Annotation
messages: Membrane

9483:EPGN
gene id: 9483:EPGN
uniprot id: F7G1N3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:KARS1
gene id: 9483:KARS1
uniprot id: F7I4R7
uniprot id: U3D440
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9483:SAP18
gene id: 9483:SAP18
uniprot id: F7IS86
names: Similarity
messages: Belongs to the SAP18 family.

9483:SEC31A
gene id: 9483:SEC31A
uniprot id: U3DIC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

9483:OR10A3
gene id: 9483:OR10A3
uniprot id: A0A2R8MD97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:NELFE
gene id: 9483:NELFE
uniprot id: U3BMY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

9483:ZNF622
gene id: 9483:ZNF622
uniprot id: U3FS90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9483:LOC100400584
gene id: 9483:LOC100400584
uniprot id: A0A5F4W1M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PRDM2
gene id: 9483:PRDM2
uniprot id: A0A2R8ML28
uniprot id: F7AGI5
names: Subcellular Location Annotation
messages: Nucleus

9483:PPBP
gene id: 9483:PPBP
uniprot id: F6WJ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:CDK5RAP3
gene id: 9483:CDK5RAP3
uniprot id: F6UTR5
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9483:SDE2
gene id: 9483:SDE2
uniprot id: F7IKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

9483:CPLANE2
gene id: 9483:CPLANE2
uniprot id: F7E9N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9483:ACOT8
gene id: 9483:ACOT8
uniprot id: F7I0J8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9483:SCML4
gene id: 9483:SCML4
uniprot id: A0A8I3WF15
names: Similarity
messages: Belongs to the SCM family.

9483:LOC100389598
gene id: 9483:LOC100389598
uniprot id: A0A8I3W4N9
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9483:TAAR5
gene id: 9483:TAAR5
uniprot id: D2X5Q7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:CA5B
gene id: 9483:CA5B
uniprot id: F7A852
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9483:VEPH1
gene id: 9483:VEPH1
uniprot id: U3B398
names: Similarity
messages: Belongs to the MELT/VEPH family.

9483:CD38
gene id: 9483:CD38
uniprot id: U3CHI9
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9483:RAD51D
gene id: 9483:RAD51D
uniprot id: A0A2R8MX66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

9483:MAP2K1
gene id: 9483:MAP2K1
uniprot id: U3CZR8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:YARS2
gene id: 9483:YARS2
uniprot id: F6T7V7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9483:CENPI
gene id: 9483:CENPI
uniprot id: F7IAQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

9483:RASGRP2
gene id: 9483:RASGRP2
uniprot id: F7HIU6
names: Similarity
messages: Belongs to the RASGRP family.

9483:KCNMB2
gene id: 9483:KCNMB2
uniprot id: F6PZE6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9483:PCK1
gene id: 9483:PCK1
uniprot id: A0A2R8MHZ1
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Monomer.

9483:ROM1
gene id: 9483:ROM1
uniprot id: F7IB94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9483:CCNH
gene id: 9483:CCNH
uniprot id: A0A2R8MAZ6
uniprot id: A0A8J8Y8G9
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9483:MAP4K3
gene id: 9483:MAP4K3
uniprot id: F6XUW1
uniprot id: U3BDA4
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9483:RPS5
gene id: 9483:RPS5
uniprot id: F6T2T8
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9483:GJB6
gene id: 9483:GJB6
uniprot id: F7IEX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:ATP6V0D1
gene id: 9483:ATP6V0D1
uniprot id: F7HR82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9483:APOE
gene id: 9483:APOE
uniprot id: U3FTG7
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9483:TRIM38
gene id: 9483:TRIM38
uniprot id: F7GAP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:RABGGTB
gene id: 9483:RABGGTB
uniprot id: F7H322
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9483:YIPF5
gene id: 9483:YIPF5
uniprot id: F7DBS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9483:F3
gene id: 9483:F3
uniprot id: U3BFC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

9483:SMAD5
gene id: 9483:SMAD5
uniprot id: U3FCQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9483:STAG3
gene id: 9483:STAG3
uniprot id: F6WTL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9483:NDC80
gene id: 9483:NDC80
uniprot id: A0A5F4W8P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9483:TM4SF5
gene id: 9483:TM4SF5
uniprot id: F6YBC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9483:UCK2
gene id: 9483:UCK2
uniprot id: F7IAY5
names: Similarity
messages: Belongs to the uridine kinase family.

9483:CPT1A
gene id: 9483:CPT1A
uniprot id: U3DBW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:MEOX2
gene id: 9483:MEOX2
uniprot id: F6YFS8
names: Subcellular Location Annotation
messages: Nucleus

9483:ZDHHC6
gene id: 9483:ZDHHC6
uniprot id: U3CJD2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:GMPR2
gene id: 9483:GMPR2
uniprot id: F6SDX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9483:GPRIN1
gene id: 9483:GPRIN1
uniprot id: F7CTE5
names: Function
messages: May be involved in neurite outgrowth.

9483:GOLM2
gene id: 9483:GOLM2
uniprot id: F6W961
uniprot id: U3BZS1
uniprot id: U3E483
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9483:CD5L
gene id: 9483:CD5L
uniprot id: F7HDX2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SAA1
gene id: 9483:SAA1
uniprot id: U3DW52
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9483:MAPK13
gene id: 9483:MAPK13
uniprot id: U3BML8
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

9483:DLL3
gene id: 9483:DLL3
uniprot id: F7INL2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:NIPBL
gene id: 9483:NIPBL
uniprot id: U3D5P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9483:PDP1
gene id: 9483:PDP1
uniprot id: F7E6B2
names: Similarity
messages: Belongs to the PP2C family.

9483:CMTM6
gene id: 9483:CMTM6
uniprot id: F6RXA3
names: Subcellular Location Annotation
messages: Membrane

9483:TOLLIP
gene id: 9483:TOLLIP
uniprot id: F6PGK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9483:DIDO1
gene id: 9483:DIDO1
uniprot id: U3C3N8
names: Subcellular Location Annotation
messages: Nucleus

9483:ACMSD
gene id: 9483:ACMSD
uniprot id: F6RC97
uniprot id: F6RCM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

9483:MED1
gene id: 9483:MED1
uniprot id: U3EHB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9483:SULT1E1
gene id: 9483:SULT1E1
uniprot id: A0A7G3QSE2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9483:ZC3HC1
gene id: 9483:ZC3HC1
uniprot id: F6T351
names: Subcellular Location Annotation
messages: Nucleus

9483:TGM7
gene id: 9483:TGM7
uniprot id: F7ICD6
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9483:ARPC4
gene id: 9483:ARPC4
uniprot id: A0A5F4W208
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection

9483:DCTN2
gene id: 9483:DCTN2
uniprot id: U3FJH5
names: Similarity
messages: Belongs to the dynactin subunit 2 family.

9483:PSEN1
gene id: 9483:PSEN1
uniprot id: U3D8G5
uniprot id: U3E9M1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9483:GALNT3
gene id: 9483:GALNT3
uniprot id: F7I6A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:LOC100385358
gene id: 9483:LOC100385358
uniprot id: U3FGA5
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9483:CARNMT1
gene id: 9483:CARNMT1
uniprot id: F6VKA5
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

9483:NIM1K
gene id: 9483:NIM1K
uniprot id: F7HK05
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:NMT1
gene id: 9483:NMT1
uniprot id: U3FB93
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9483:CFAP126
gene id: 9483:CFAP126
uniprot id: F7IFB9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9483:HMBOX1
gene id: 9483:HMBOX1
uniprot id: F6W5X9
uniprot id: F6WQ92
uniprot id: U3BNX7
uniprot id: U3DHA5
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100390645
gene id: 9483:LOC100390645
uniprot id: F7IA43
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:GJB3
gene id: 9483:GJB3
uniprot id: F6VAQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:B3GNT3
gene id: 9483:B3GNT3
uniprot id: A0A2R8M6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:TUFM
gene id: 9483:TUFM
uniprot id: F7IMS0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9483:HDAC3
gene id: 9483:HDAC3
uniprot id: F6RM17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9483:TCN1
gene id: 9483:TCN1
uniprot id: F7GX30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9483:DDX59
gene id: 9483:DDX59
uniprot id: U3EVA9
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

9483:UNC119
gene id: 9483:UNC119
uniprot id: F7IB75
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9483:STX5
gene id: 9483:STX5
uniprot id: F7AH00
names: Similarity
messages: Belongs to the syntaxin family.

9483:LOC108591413
gene id: 9483:LOC108591413
uniprot id: F7GWA8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:EXOC1
gene id: 9483:EXOC1
uniprot id: A0A2R8MK81
uniprot id: F6TDJ1
uniprot id: U3BV40
uniprot id: U3DVK3
uniprot id: U3FIW4
names: Similarity
messages: Belongs to the SEC3 family.

9483:TGFB3
gene id: 9483:TGFB3
uniprot id: F7IQT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

9483:FAM13A
gene id: 9483:FAM13A
uniprot id: F7EXT0
uniprot id: F7FR29
uniprot id: F7G2B1
uniprot id: U3FMN3
names: Similarity
messages: Belongs to the FAM13 family.

9483:MRPL54
gene id: 9483:MRPL54
uniprot id: F7GZG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9483:LOC100412773
gene id: 9483:LOC100412773
uniprot id: A0A8I3X205
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CLDN6
gene id: 9483:CLDN6
uniprot id: U3E0Z7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:LOC100415168
gene id: 9483:LOC100415168
uniprot id: A0A2R8MPB4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:LHFPL2
gene id: 9483:LHFPL2
uniprot id: A0A8I3WQE4
names: Subcellular Location Annotation
messages: Membrane

9483:BASP1
gene id: 9483:BASP1
uniprot id: F6PRD3
names: Similarity
messages: Belongs to the BASP1 family.

9483:TRIP12
gene id: 9483:TRIP12
uniprot id: A0A8J8XHJ3
uniprot id: F7EIN3
uniprot id: U3EA63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9483:LOC100896161
gene id: 9483:LOC100896161
uniprot id: F6VEW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:IL6ST
gene id: 9483:IL6ST
uniprot id: Q0GKF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9483:LARS1
gene id: 9483:LARS1
uniprot id: U3D7F0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9483:POSTN
gene id: 9483:POSTN
uniprot id: A0A2R8PHI4
uniprot id: A0A8I4A2J5
uniprot id: F6R2K3
uniprot id: F6R2K9
uniprot id: F6RBY2
uniprot id: U3BT91
uniprot id: U3DGX9
names: Subcellular Location Annotation
messages: extracellular matrix

9483:MOK
gene id: 9483:MOK
uniprot id: A0A8I3WSD1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:GINS1
gene id: 9483:GINS1
uniprot id: U3EFA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9483:SLC30A4
gene id: 9483:SLC30A4
uniprot id: F7EZU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9483:EZH1
gene id: 9483:EZH1
uniprot id: U3EHI2
names: Subcellular Location Annotation
messages: Nucleus

9483:MAP7
gene id: 9483:MAP7
uniprot id: F7GZT3
uniprot id: F7GZV8
names: Similarity
messages: Belongs to the MAP7 family.

9483:GJA5
gene id: 9483:GJA5
uniprot id: A0A654IC83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:HNRNPH2
gene id: 9483:HNRNPH2
uniprot id: U3EAJ2
names: Subcellular Location Annotation
messages: nucleoplasm

9483:B3GNT2
gene id: 9483:B3GNT2
uniprot id: F7DAC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:NAP1L4
gene id: 9483:NAP1L4
uniprot id: A0A5F4VVM7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:DPT
gene id: 9483:DPT
uniprot id: U3E618
names: Similarity
messages: Belongs to the dermatopontin family.

9483:FBLN7
gene id: 9483:FBLN7
uniprot id: U3DR50
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:S100Z
gene id: 9483:S100Z
uniprot id: A0A8I3WFT9
names: Similarity
messages: Belongs to the S-100 family.

9483:PRDX6
gene id: 9483:PRDX6
uniprot id: F7ICM8
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9483:CCT2
gene id: 9483:CCT2
uniprot id: A0A8I3WI23
uniprot id: U3FVV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9483:TSPAN9
gene id: 9483:TSPAN9
uniprot id: A0A8I3WP60
uniprot id: U3EI08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:GOSR1
gene id: 9483:GOSR1
uniprot id: A0A8I3VZ75
uniprot id: F6WJ38
uniprot id: U3DM31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9483:MPP1
gene id: 9483:MPP1
uniprot id: B0KWU3
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

9483:FAM166C
gene id: 9483:FAM166C
uniprot id: U3BNZ1
names: Similarity
messages: Belongs to the CIMIP2 family.

9483:METTL14
gene id: 9483:METTL14
uniprot id: A0A2R8NAC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.

9483:TMEM176B
gene id: 9483:TMEM176B
uniprot id: U3CDT7
names: Similarity
messages: Belongs to the TMEM176 family.

9483:ARRDC3
gene id: 9483:ARRDC3
uniprot id: A0A2R8MNN7
names: Similarity
messages: Belongs to the arrestin family.

9483:SLC7A11
gene id: 9483:SLC7A11
uniprot id: U3ENJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9483:SELP
gene id: 9483:SELP
uniprot id: A0A2R8MF93
uniprot id: A0A8I3WN67
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CXCL13
gene id: 9483:CXCL13
uniprot id: A0A5F4WD53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:DMC1
gene id: 9483:DMC1
uniprot id: F6RJX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

9483:SORCS3
gene id: 9483:SORCS3
uniprot id: F6YYH9
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9483:TPRA1
gene id: 9483:TPRA1
uniprot id: F6Y3P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9483:FOXB2
gene id: 9483:FOXB2
uniprot id: A0A2R8MU65
names: Subcellular Location Annotation
messages: Nucleus

9483:CEP63
gene id: 9483:CEP63
uniprot id: F7I115
uniprot id: U3DNZ7
names: Similarity
messages: Belongs to the CEP63 family.

9483:MOS
gene id: 9483:MOS
uniprot id: F7INI9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:PDGFRL
gene id: 9483:PDGFRL
uniprot id: U3BFP6
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

9483:TNFSF9
gene id: 9483:TNFSF9
uniprot id: F7CLT9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:CALB1
gene id: 9483:CALB1
uniprot id: U3CTY1
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

9483:PAX4
gene id: 9483:PAX4
uniprot id: B0VXF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the paired homeobox family.
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

9483:PHGDH
gene id: 9483:PHGDH
uniprot id: U3DVF2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9483:NCDN
gene id: 9483:NCDN
uniprot id: U3BUT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

9483:CUL2
gene id: 9483:CUL2
uniprot id: F6SU62
names: Similarity
messages: Belongs to the cullin family.

9483:TRAPPC1
gene id: 9483:TRAPPC1
uniprot id: F7I3W8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9483:D2HGDH
gene id: 9483:D2HGDH
uniprot id: F7F4Q6
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9483:FOXR2
gene id: 9483:FOXR2
uniprot id: A0A2R8M5S6
names: Subcellular Location Annotation
messages: Nucleus

9483:BAP1
gene id: 9483:BAP1
uniprot id: F7GM69
names: Similarity
messages: Belongs to the peptidase C12 family.

9483:SYNDIG1L
gene id: 9483:SYNDIG1L
uniprot id: F7HKE0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9483:CTPS1
gene id: 9483:CTPS1
uniprot id: F6SKL8
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9483:IDNK
gene id: 9483:IDNK
uniprot id: F7F3U9
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

9483:AP1S2
gene id: 9483:AP1S2
uniprot id: A0A2R8PC25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9483:DNAJC2
gene id: 9483:DNAJC2
uniprot id: U3F6A2
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: Nucleus
messages: cytosol

9483:SRXN1
gene id: 9483:SRXN1
uniprot id: F7I4C5
names: Similarity
messages: Belongs to the sulfiredoxin family.

9483:ADGRL3
gene id: 9483:ADGRL3
uniprot id: A0A2R8MM16
uniprot id: F7IQX7
uniprot id: F7IQX8
names: Subcellular Location Annotation
messages: Membrane

9483:YPEL3
gene id: 9483:YPEL3
uniprot id: A0A2R8MGE5
names: Similarity
messages: Belongs to the yippee family.

9483:ACTR6
gene id: 9483:ACTR6
uniprot id: U3EAM1
names: Similarity
messages: Belongs to the actin family.

9483:SLC20A2
gene id: 9483:SLC20A2
uniprot id: F7I4B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

9483:SDHAF1
gene id: 9483:SDHAF1
uniprot id: A0A2R8M6Q6
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9483:APOO
gene id: 9483:APOO
uniprot id: F7I3C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9483:HINT1
gene id: 9483:HINT1
uniprot id: A0A2R8M646
names: Similarity
messages: Belongs to the HINT family.

9483:COX18
gene id: 9483:COX18
uniprot id: U3BCA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9483:SEPTIN9
gene id: 9483:SEPTIN9
uniprot id: A0A8I3W584
uniprot id: F7GEF9
uniprot id: F7HJ35
uniprot id: F7HJ38
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9483:NOP16
gene id: 9483:NOP16
uniprot id: F7I665
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9483:LIX1
gene id: 9483:LIX1
uniprot id: F7I554
names: Similarity
messages: Belongs to the LIX1 family.

9483:CCL11
gene id: 9483:CCL11
uniprot id: F7I909
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:ENDOG
gene id: 9483:ENDOG
uniprot id: B0KWD9
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9483:TOR4A
gene id: 9483:TOR4A
uniprot id: F7FEP2
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9483:ITK
gene id: 9483:ITK
uniprot id: F7IG16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9483:MRPL42
gene id: 9483:MRPL42
uniprot id: U3FJI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9483:COQ3
gene id: 9483:COQ3
uniprot id: F7IL54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

9483:PDF
gene id: 9483:PDF
uniprot id: U3EZZ0
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

9483:ARRDC2
gene id: 9483:ARRDC2
uniprot id: F7BF58
uniprot id: F7BF67
names: Similarity
messages: Belongs to the arrestin family.

9483:EMP3
gene id: 9483:EMP3
uniprot id: F6PYE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9483:MRPL44
gene id: 9483:MRPL44
uniprot id: U3DQE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

9483:SYNGR1
gene id: 9483:SYNGR1
uniprot id: A0A2R8P6T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9483:ACTBL2
gene id: 9483:ACTBL2
uniprot id: A0A8I3WN26
names: Similarity
messages: Belongs to the actin family.

9483:SOX2
gene id: 9483:SOX2
uniprot id: F7H274
names: Subcellular Location Annotation
messages: Nucleus

9483:HSF2
gene id: 9483:HSF2
uniprot id: U3D7P6
uniprot id: U3D7X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9483:LOC100389040
gene id: 9483:LOC100389040
uniprot id: U3FDP9
names: Similarity
messages: Belongs to the copine family.

9483:CDH12
gene id: 9483:CDH12
uniprot id: U3EPZ9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:BCL2L1
gene id: 9483:BCL2L1
uniprot id: F7IT36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9483:WFDC12
gene id: 9483:WFDC12
uniprot id: A4K2U1
names: Function
names: Subcellular Location Annotation
messages: Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity).
messages: Secreted

9483:NECTIN3
gene id: 9483:NECTIN3
uniprot id: U3B0A4
names: Similarity
messages: Belongs to the nectin family.

9483:FAM98A
gene id: 9483:FAM98A
uniprot id: U3EAA8
names: Similarity
messages: Belongs to the FAM98 family.

9483:PRRX1
gene id: 9483:PRRX1
uniprot id: F7GR75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9483:RNASEH2B
gene id: 9483:RNASEH2B
uniprot id: U3ERP0
uniprot id: U3FQM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

9483:H1-2
gene id: 9483:H1-2
uniprot id: U3EBN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9483:CTH
gene id: 9483:CTH
uniprot id: F7H0R1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9483:LPAR5
gene id: 9483:LPAR5
uniprot id: F6XUY5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:FLVCR1
gene id: 9483:FLVCR1
uniprot id: F6W512
names: Subcellular Location Annotation
messages: Membrane

9483:LOC100408124
gene id: 9483:LOC100408124
uniprot id: A0A8I3W279
names: Similarity
messages: Belongs to the LCE family.

9483:CPEB1
gene id: 9483:CPEB1
uniprot id: F7HRU4
uniprot id: U3FM09
names: Similarity
messages: Belongs to the RRM CPEB family.

9483:NDUFAF4
gene id: 9483:NDUFAF4
uniprot id: F7IGP2
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9483:MED9
gene id: 9483:MED9
uniprot id: F7C678
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:MRPL27
gene id: 9483:MRPL27
uniprot id: F7IG40
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9483:LOC100397154
gene id: 9483:LOC100397154
uniprot id: F6XRI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

9483:MX1
gene id: 9483:MX1
uniprot id: U3EGN4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9483:SPOCK3
gene id: 9483:SPOCK3
uniprot id: F7HYW9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:HSDL1
gene id: 9483:HSDL1
uniprot id: U3ARF3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:FUT4
gene id: 9483:FUT4
uniprot id: A0A8I3WR33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9483:OXTR
gene id: 9483:OXTR
uniprot id: F7ILY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9483:MAGT1
gene id: 9483:MAGT1
uniprot id: F7HX46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:ACAA2
gene id: 9483:ACAA2
uniprot id: U3FQH9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9483:MDGA2
gene id: 9483:MDGA2
uniprot id: U3DEF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:SLC25A18
gene id: 9483:SLC25A18
uniprot id: U3DR59
uniprot id: U3E4V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:KDELR1
gene id: 9483:KDELR1
uniprot id: U3BKM7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:GMDS
gene id: 9483:GMDS
uniprot id: A0A2R8PJ06
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9483:MRPS21
gene id: 9483:MRPS21
uniprot id: F7HBX1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9483:CADM3
gene id: 9483:CADM3
uniprot id: F7D5S0
uniprot id: U3DTG8
names: Similarity
messages: Belongs to the nectin family.

9483:SERINC3
gene id: 9483:SERINC3
uniprot id: F7DZ63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9483:FUNDC1
gene id: 9483:FUNDC1
uniprot id: U3DRL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9483:UBE2T
gene id: 9483:UBE2T
uniprot id: U3EFD1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:SKIC2
gene id: 9483:SKIC2
uniprot id: U3F5H6
names: Subcellular Location Annotation
messages: Cytoplasm

9483:GJA1
gene id: 9483:GJA1
uniprot id: F6S7E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:CHD8
gene id: 9483:CHD8
uniprot id: A0A5K1TW24
uniprot id: A0A8J8XI99
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

9483:AGK
gene id: 9483:AGK
uniprot id: U3CSI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9483:SMIM18
gene id: 9483:SMIM18
uniprot id: U3FM97
names: Subcellular Location Annotation
messages: Membrane

9483:CAJA-DPA1
gene id: 9483:CAJA-DPA1
uniprot id: A0A2R8MUF5
names: Similarity
messages: Belongs to the MHC class II family.

9483:AQP2
gene id: 9483:AQP2
uniprot id: F7H018
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:LOC100406481
gene id: 9483:LOC100406481
uniprot id: F7CVP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9483:PLP2
gene id: 9483:PLP2
uniprot id: F6WQM2
names: Subcellular Location Annotation
messages: Membrane

9483:MASP1
gene id: 9483:MASP1
uniprot id: F6R2R9
uniprot id: U3EHF2
uniprot id: U3FSL2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:EPHB1
gene id: 9483:EPHB1
uniprot id: U3EWE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9483:GAL
gene id: 9483:GAL
uniprot id: U3FCX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

9483:INTS10
gene id: 9483:INTS10
uniprot id: A0A2R8PHP2
uniprot id: A0A5F4W2V6
uniprot id: U3EAM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9483:BCKDHA
gene id: 9483:BCKDHA
uniprot id: U3DKQ5
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.

9483:IP6K1
gene id: 9483:IP6K1
uniprot id: U3EJP7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9483:CSMD1
gene id: 9483:CSMD1
uniprot id: U3D3K9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:NFYA
gene id: 9483:NFYA
uniprot id: F6PHK9
uniprot id: U3EB25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9483:HSCB
gene id: 9483:HSCB
uniprot id: A0A2R8M6R9
uniprot id: A0A8I3WPU2
names: Similarity
messages: Belongs to the HscB family.

9483:SSBP1
gene id: 9483:SSBP1
uniprot id: A0A2R8MT72
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9483:PEA15
gene id: 9483:PEA15
uniprot id: F7ICU5
names: Subcellular Location Annotation
messages: Cytoplasm

9483:INSIG1
gene id: 9483:INSIG1
uniprot id: F6XME3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9483:UQCRQ
gene id: 9483:UQCRQ
uniprot id: F7FA82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9483:UGP2
gene id: 9483:UGP2
uniprot id: A0A8I3WLC0
uniprot id: F6QUM6
uniprot id: U3BG80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9483:NEK6
gene id: 9483:NEK6
uniprot id: A0A8I3ZZ25
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:CCT4
gene id: 9483:CCT4
uniprot id: F7EYY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9483:KCNQ5
gene id: 9483:KCNQ5
uniprot id: U3DD98
uniprot id: U3DLN2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:DZIP3
gene id: 9483:DZIP3
uniprot id: F7HI26
names: Subcellular Location Annotation
messages: Cytoplasm

9483:APOA4
gene id: 9483:APOA4
uniprot id: B0KWR0
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9483:EBP
gene id: 9483:EBP
uniprot id: F7CM26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:CORO1C
gene id: 9483:CORO1C
uniprot id: U3BZ09
names: Similarity
messages: Belongs to the WD repeat coronin family.

9483:OTX1
gene id: 9483:OTX1
uniprot id: F7GZ10
names: Subcellular Location Annotation
messages: Nucleus

9483:PDCD4
gene id: 9483:PDCD4
uniprot id: U3BXK1
names: Similarity
messages: Belongs to the PDCD4 family.

9483:PPAN
gene id: 9483:PPAN
uniprot id: F7HMT1
names: Subcellular Location Annotation
messages: nucleolus

9483:MAPK9
gene id: 9483:MAPK9
uniprot id: A0A2R8MHE7
uniprot id: U3CSF4
uniprot id: U3E7L6
uniprot id: U3EWQ9
uniprot id: U3F1Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9483:HSD17B12
gene id: 9483:HSD17B12
uniprot id: F7DYP3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:ACTR3
gene id: 9483:ACTR3
uniprot id: F7GST1
names: Similarity
messages: Belongs to the actin family.

9483:ARK2N
gene id: 9483:ARK2N
uniprot id: A0A8I4A5C2
uniprot id: U3EJW0
names: Subcellular Location Annotation
messages: Nucleus

9483:BLCAP
gene id: 9483:BLCAP
uniprot id: F6XV20
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

9483:HOGA1
gene id: 9483:HOGA1
uniprot id: F7B5W8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9483:LPCAT4
gene id: 9483:LPCAT4
uniprot id: U3D5S4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9483:ZSCAN29
gene id: 9483:ZSCAN29
uniprot id: U3DM54
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9483:RTN4IP1
gene id: 9483:RTN4IP1
uniprot id: F7IQ43
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9483:ZDHHC12
gene id: 9483:ZDHHC12
uniprot id: U3C6Y4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:TRIM2
gene id: 9483:TRIM2
uniprot id: U3DM64
uniprot id: U3F3S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9483:PEPD
gene id: 9483:PEPD
uniprot id: F6V2W6
uniprot id: F6XAG3
names: Similarity
messages: Belongs to the peptidase M24B family.

9483:B3GNT6
gene id: 9483:B3GNT6
uniprot id: A0A2R8M8Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:LOC100409166
gene id: 9483:LOC100409166
uniprot id: F7I5Q9
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9483:MYC
gene id: 9483:MYC
uniprot id: P49032
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity).
messages: Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-328 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
messages: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.
messages: nucleolus
messages: nucleoplasm

9483:TRIM63
gene id: 9483:TRIM63
uniprot id: F7IA12
names: Subcellular Location Annotation
messages: Cytoplasm

9483:FMO1
gene id: 9483:FMO1
uniprot id: A0A221I096
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:A4GNT
gene id: 9483:A4GNT
uniprot id: F6Y451
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9483:PF4
gene id: 9483:PF4
uniprot id: F6WJ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:TMEM267
gene id: 9483:TMEM267
uniprot id: U3FKE8
names: Subcellular Location Annotation
messages: Membrane

9483:SLC15A2
gene id: 9483:SLC15A2
uniprot id: F6YUC3
uniprot id: F7CVE6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9483:FAM187A
gene id: 9483:FAM187A
uniprot id: A0A5F4WC65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9483:CADM2
gene id: 9483:CADM2
uniprot id: U3CI28
names: Similarity
messages: Belongs to the nectin family.

9483:KREMEN1
gene id: 9483:KREMEN1
uniprot id: U3DHG7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

9483:RARA
gene id: 9483:RARA
uniprot id: F6VKD1
uniprot id: F6WEA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9483:DUSP9
gene id: 9483:DUSP9
uniprot id: A0A8J8XJC0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9483:GRIK1
gene id: 9483:GRIK1
uniprot id: A0A2R8MNS3
uniprot id: A0A2R8MRR1
uniprot id: A0A2R8MVG0
uniprot id: A0A2R8P6H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9483:TRAPPC6A
gene id: 9483:TRAPPC6A
uniprot id: U3EM73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9483:RNASE1
gene id: 9483:RNASE1
uniprot id: F7GJ91
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9483:ILKAP
gene id: 9483:ILKAP
uniprot id: U3FLN4
names: Similarity
messages: Belongs to the PP2C family.

9483:PNLIP
gene id: 9483:PNLIP
uniprot id: F7FR78
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:ADGRL4
gene id: 9483:ADGRL4
uniprot id: F7BJ41
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:GRPR
gene id: 9483:GRPR
uniprot id: F6Z8A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:FAM216B
gene id: 9483:FAM216B
uniprot id: A0A8I3WHX3
names: Similarity
messages: Belongs to the FAM216 family.

9483:ZSCAN16
gene id: 9483:ZSCAN16
uniprot id: F7IFE6
names: Subcellular Location Annotation
messages: Nucleus

9483:HEPHL1
gene id: 9483:HEPHL1
uniprot id: F6RM70
names: Similarity
messages: Belongs to the multicopper oxidase family.

9483:NUCB2
gene id: 9483:NUCB2
uniprot id: F7IH71
names: Similarity
messages: Belongs to the nucleobindin family.

9483:RAD54L2
gene id: 9483:RAD54L2
uniprot id: U3BCU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9483:RFX3
gene id: 9483:RFX3
uniprot id: F7ESI7
names: Subcellular Location Annotation
messages: Nucleus

9483:PITX2
gene id: 9483:PITX2
uniprot id: F6Q5G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9483:C3AR1
gene id: 9483:C3AR1
uniprot id: F7IQB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9483:CYP1A1
gene id: 9483:CYP1A1
uniprot id: F7DIB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9483:EIF1B
gene id: 9483:EIF1B
uniprot id: F7G7W3
names: Similarity
messages: Belongs to the SUI1 family.

9483:TMEM35B
gene id: 9483:TMEM35B
uniprot id: U3CP76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9483:CEP44
gene id: 9483:CEP44
uniprot id: A0A5F4WK08
uniprot id: U3EKX5
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9483:MMP16
gene id: 9483:MMP16
uniprot id: A0A2R8M760
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9483:SUPT3H
gene id: 9483:SUPT3H
uniprot id: U3D6N9
names: Subcellular Location Annotation
messages: Nucleus

9483:MCM6
gene id: 9483:MCM6
uniprot id: U3DPS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9483:MIS12
gene id: 9483:MIS12
uniprot id: F7EAN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9483:SPACA4
gene id: 9483:SPACA4
uniprot id: A0A5F4W347
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9483:DDX55
gene id: 9483:DDX55
uniprot id: F7IR35
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9483:SUCLG1
gene id: 9483:SUCLG1
uniprot id: U3BBP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9483:DAP3
gene id: 9483:DAP3
uniprot id: U3EF11
uniprot id: U3EKP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

9483:PNRC2
gene id: 9483:PNRC2
uniprot id: U3FSE8
names: Subcellular Location Annotation
messages: Nucleus

9483:TULP3
gene id: 9483:TULP3
uniprot id: U3E157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9483:CDK7
gene id: 9483:CDK7
uniprot id: F7IRE4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9483:SSU72
gene id: 9483:SSU72
uniprot id: F7ETE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9483:AGTR2
gene id: 9483:AGTR2
uniprot id: F6Q2S1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

9483:GNPNAT1
gene id: 9483:GNPNAT1
uniprot id: F7CEE3
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9483:BRS3
gene id: 9483:BRS3
uniprot id: F7EPZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9483:DLL1
gene id: 9483:DLL1
uniprot id: U3F3S0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9483:SLC1A4
gene id: 9483:SLC1A4
uniprot id: F7FQH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9483:WNT8B
gene id: 9483:WNT8B
uniprot id: A0A2R8M5J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:MLF1
gene id: 9483:MLF1
uniprot id: U3CVU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9483:TTC9
gene id: 9483:TTC9
uniprot id: F7G5Z7
names: Similarity
messages: Belongs to the TTC9 family.

9483:MALSU1
gene id: 9483:MALSU1
uniprot id: F7I240
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9483:BYSL
gene id: 9483:BYSL
uniprot id: F6XKE7
names: Similarity
messages: Belongs to the bystin family.

9483:LOC108591274
gene id: 9483:LOC108591274
uniprot id: F7FDP2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9483:LOC100390666
gene id: 9483:LOC100390666
uniprot id: F7I248
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: Lipid droplet
messages: May activate the NF-kappa-B signaling pathway.

9483:DTD2
gene id: 9483:DTD2
uniprot id: F7CPR7
names: Similarity
messages: Belongs to the DTD family.

9483:CBFA2T2
gene id: 9483:CBFA2T2
uniprot id: U3C6N7
names: Similarity
messages: Belongs to the CBFA2T family.

9483:BCAR1
gene id: 9483:BCAR1
uniprot id: U3BL20
uniprot id: U3DHP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9483:GNG13
gene id: 9483:GNG13
uniprot id: A0A8I3X7B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:STT3A
gene id: 9483:STT3A
uniprot id: U3CCA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9483:PTS
gene id: 9483:PTS
uniprot id: F7I609
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9483:LOC100406466
gene id: 9483:LOC100406466
uniprot id: A0A7R8C353
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:GRIK2
gene id: 9483:GRIK2
uniprot id: F7IBF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9483:RPL24
gene id: 9483:RPL24
uniprot id: F6PN21
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9483:SVOP
gene id: 9483:SVOP
uniprot id: U3DJI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9483:IRAK4
gene id: 9483:IRAK4
uniprot id: F6ZUT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9483:JPT2
gene id: 9483:JPT2
uniprot id: U3FN87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9483:TAF8
gene id: 9483:TAF8
uniprot id: F6WY31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

9483:GPX5
gene id: 9483:GPX5
uniprot id: F7I3U2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9483:RAB3IL1
gene id: 9483:RAB3IL1
uniprot id: U3FS07
names: Similarity
messages: Belongs to the SEC2 family.

9483:LSM1
gene id: 9483:LSM1
uniprot id: F7B4D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9483:NGLY1
gene id: 9483:NGLY1
uniprot id: F6PRJ8
uniprot id: F6TYG1
uniprot id: F7AI61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

9483:ACTA1
gene id: 9483:ACTA1
uniprot id: F7FWZ0
names: Similarity
messages: Belongs to the actin family.

9483:SPI1
gene id: 9483:SPI1
uniprot id: U3D003
uniprot id: U3DY02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:SLC34A2
gene id: 9483:SLC34A2
uniprot id: F7F9F9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9483:UBE2R2
gene id: 9483:UBE2R2
uniprot id: F7E9R9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:KIF13A
gene id: 9483:KIF13A
uniprot id: A0A2R8MWV9
uniprot id: A0A2R8PC29
uniprot id: F6RG27
uniprot id: F6S2B2
uniprot id: U3EYE7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:NSG2
gene id: 9483:NSG2
uniprot id: U3CYN4
names: Similarity
messages: Belongs to the NSG family.

9483:CPN1
gene id: 9483:CPN1
uniprot id: F7ICG5
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:SSTR3
gene id: 9483:SSTR3
uniprot id: U3EF39
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:ACTR1B
gene id: 9483:ACTR1B
uniprot id: U3FEU3
names: Similarity
messages: Belongs to the actin family.

9483:NAT9
gene id: 9483:NAT9
uniprot id: U3ECW1
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

9483:WNT10B
gene id: 9483:WNT10B
uniprot id: F7IIN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:CYP7B1
gene id: 9483:CYP7B1
uniprot id: F6UDE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9483:HSPB3
gene id: 9483:HSPB3
uniprot id: F7HVA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9483:MAP1LC3A
gene id: 9483:MAP1LC3A
uniprot id: F6QPF6
names: Similarity
messages: Belongs to the ATG8 family.

9483:ATP2C2
gene id: 9483:ATP2C2
uniprot id: A0A5F4VXF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:BMP2
gene id: 9483:BMP2
uniprot id: F7G4N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9483:SPINK4
gene id: 9483:SPINK4
uniprot id: F7I1Z5
names: Subcellular Location Annotation
messages: Secreted

9483:CHD7
gene id: 9483:CHD7
uniprot id: U3EHJ9
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9483:TMED7
gene id: 9483:TMED7
uniprot id: U3EUI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9483:TAS2R1
gene id: 9483:TAS2R1
uniprot id: A0A1C9ZNM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9483:PEMT
gene id: 9483:PEMT
uniprot id: U3F8M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9483:ARSK
gene id: 9483:ARSK
uniprot id: F7GPX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome

9483:CEBPG
gene id: 9483:CEBPG
uniprot id: F7GML5
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

9483:UBE4A
gene id: 9483:UBE4A
uniprot id: U3AVF7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

9483:GPBP1L1
gene id: 9483:GPBP1L1
uniprot id: U3E0X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9483:THNSL2
gene id: 9483:THNSL2
uniprot id: F6T1U5
uniprot id: U3AZV5
names: Similarity
messages: Belongs to the threonine synthase family.

9483:IRF6
gene id: 9483:IRF6
uniprot id: F7E8C9
names: Subcellular Location Annotation
messages: Nucleus

9483:BPNT2
gene id: 9483:BPNT2
uniprot id: A0A5F4WL61
uniprot id: F6Y5S8
uniprot id: U3FL10
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily.
messages: Contains N-linked glycan resistant to endoglycosydase H.
messages: Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4.
messages: Golgi apparatus
messages: Strongly inhibited by lithium.
messages: trans-Golgi network membrane

9483:AP3M2
gene id: 9483:AP3M2
uniprot id: F7DPW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9483:RPP14
gene id: 9483:RPP14
uniprot id: F6RR62
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9483:KIF5B
gene id: 9483:KIF5B
uniprot id: F6YJP5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:LOC100413217
gene id: 9483:LOC100413217
uniprot id: F7FGL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:GSTA4
gene id: 9483:GSTA4
uniprot id: F7GQS8
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9483:CKS2
gene id: 9483:CKS2
uniprot id: F7HV56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9483:SNRPF
gene id: 9483:SNRPF
uniprot id: F6UZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9483:HAX1
gene id: 9483:HAX1
uniprot id: U3CV43
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

9483:ACTA2
gene id: 9483:ACTA2
uniprot id: A0A8I3XF03
names: Similarity
messages: Belongs to the actin family.

9483:SLC25A12
gene id: 9483:SLC25A12
uniprot id: F7BXR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:AIMP2
gene id: 9483:AIMP2
uniprot id: F7C5F2
uniprot id: U3FIK2
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9483:AP4S1
gene id: 9483:AP4S1
uniprot id: A0A2R8M2V0
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9483:BABAM2
gene id: 9483:BABAM2
uniprot id: F7BJZ6
uniprot id: U3FDV6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9483:KRT13
gene id: 9483:KRT13
uniprot id: F7AP91
names: Similarity
messages: Belongs to the intermediate filament family.

9483:GAPVD1
gene id: 9483:GAPVD1
uniprot id: U3DGI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9483:OR2T10
gene id: 9483:OR2T10
uniprot id: F7IFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:OR2T27
gene id: 9483:OR2T27
uniprot id: F7I327
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:OLFM2
gene id: 9483:OLFM2
uniprot id: A0A2R8PDX8
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9483:PEX2
gene id: 9483:PEX2
uniprot id: F6U7X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9483:CHST4
gene id: 9483:CHST4
uniprot id: F7HV48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9483:SYT17
gene id: 9483:SYT17
uniprot id: F7HH86
uniprot id: U3ETE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9483:SRD5A3
gene id: 9483:SRD5A3
uniprot id: F6SQM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9483:ITM2C
gene id: 9483:ITM2C
uniprot id: F7A817
uniprot id: U3CUY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9483:TMSB10
gene id: 9483:TMSB10
uniprot id: F7FGR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9483:C3H4orf47
gene id: 9483:C3H4orf47
uniprot id: U3ECH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP96 family.
messages: centrosome

9483:C9H12orf43
gene id: 9483:C9H12orf43
uniprot id: U3EC11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

9483:GJA9
gene id: 9483:GJA9
uniprot id: F7CMI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:SLC9A8
gene id: 9483:SLC9A8
uniprot id: F6PN51
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9483:AIF1
gene id: 9483:AIF1
uniprot id: U3D2H7
names: Subcellular Location Annotation
messages: ruffle membrane

9483:CORIN
gene id: 9483:CORIN
uniprot id: A0A2R8P1C2
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:APPL2
gene id: 9483:APPL2
uniprot id: U3BC20
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9483:PLA2G2A
gene id: 9483:PLA2G2A
uniprot id: U3BS74
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9483:SERPINF1
gene id: 9483:SERPINF1
uniprot id: F6WRV2
names: Similarity
messages: Belongs to the serpin family.

9483:DPPA5
gene id: 9483:DPPA5
uniprot id: F7G9E9
names: Similarity
messages: Belongs to the KHDC1 family.

9483:MAP7D2
gene id: 9483:MAP7D2
uniprot id: F7HHJ6
uniprot id: U3BW88
names: Similarity
messages: Belongs to the MAP7 family.

9483:CYP2C8
gene id: 9483:CYP2C8
uniprot id: A0P8Q9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:TAGLN2
gene id: 9483:TAGLN2
uniprot id: U3EHG7
names: Similarity
messages: Belongs to the calponin family.

9483:GPR68
gene id: 9483:GPR68
uniprot id: F7IGI0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:LOC100414113
gene id: 9483:LOC100414113
uniprot id: A0A8I3WN60
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:EFTUD2
gene id: 9483:EFTUD2
uniprot id: F7I888
names: Subcellular Location Annotation
messages: Nucleus

9483:PHF19
gene id: 9483:PHF19
uniprot id: F6ZWU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9483:AGPAT4
gene id: 9483:AGPAT4
uniprot id: U3DG12
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9483:DLX2
gene id: 9483:DLX2
uniprot id: F6WHW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9483:LOC103788996
gene id: 9483:LOC103788996
uniprot id: F7G1P7
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9483:SCAMP4
gene id: 9483:SCAMP4
uniprot id: U3DGC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9483:SUMO3
gene id: 9483:SUMO3
uniprot id: U3EFP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9483:NAPG
gene id: 9483:NAPG
uniprot id: U3D967
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9483:MFSD6
gene id: 9483:MFSD6
uniprot id: F7IHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9483:PPAT
gene id: 9483:PPAT
uniprot id: U3AS03
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9483:PABIR2
gene id: 9483:PABIR2
uniprot id: A0A8I3W0X8
uniprot id: A0A8J8Y7Y1
names: Similarity
messages: Belongs to the FAM122 family.

9483:METTL4
gene id: 9483:METTL4
uniprot id: U3F057
names: Similarity
messages: Belongs to the MT-A70-like family.

9483:MAPRE3
gene id: 9483:MAPRE3
uniprot id: U3CWD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9483:FAM221A
gene id: 9483:FAM221A
uniprot id: U3AYF1
names: Similarity
messages: Belongs to the FAM221 family.

9483:NUPR1
gene id: 9483:NUPR1
uniprot id: U3FHX8
names: Similarity
messages: Belongs to the NUPR family.

9483:LOC108590303
gene id: 9483:LOC108590303
uniprot id: F6S7T1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9483:PPP3CB
gene id: 9483:PPP3CB
uniprot id: A0A2R8MN08
uniprot id: F7GI92
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9483:GDF9
gene id: 9483:GDF9
uniprot id: F7FNW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9483:TARDBP
gene id: 9483:TARDBP
uniprot id: F7CL81
names: Subcellular Location Annotation
messages: Nucleus

9483:TLR8
gene id: 9483:TLR8
uniprot id: F6RY00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9483:GDI2
gene id: 9483:GDI2
uniprot id: U3C6M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9483:LOC100388968
gene id: 9483:LOC100388968
uniprot id: F7HAR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CYP26B1
gene id: 9483:CYP26B1
uniprot id: F7GVB0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:SLC43A2
gene id: 9483:SLC43A2
uniprot id: F7GZB3
names: Subcellular Location Annotation
messages: Membrane

9483:LHX1
gene id: 9483:LHX1
uniprot id: F6UGX4
names: Subcellular Location Annotation
messages: Nucleus

9483:RNPEP
gene id: 9483:RNPEP
uniprot id: U3E9J7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9483:AGXT
gene id: 9483:AGXT
uniprot id: P31029
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the transamination between L-serine and pyruvate and weakly contributes to gluconeogenesis from the L-serine metabolism.
messages: Catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification.
messages: Homodimer.
messages: Mitochondrion matrix
messages: Peroxisome
messages: The intracellular compartmentalization of AGTX in mammalian hepatocytes is species dependent. In human and rabbit, AGTX is peroxisomal. In new world monkeys (marmoset) and rodents (rat and mouse), it is distributed approximately evenly between peroxisomes and mitochondria. In carnivores, like cat, the great majority of the enzyme is mitochondrial with only a small proportion being peroxisomal.

9483:ZNF263
gene id: 9483:ZNF263
uniprot id: F7EWU1
names: Subcellular Location Annotation
messages: Nucleus

9483:HPGD
gene id: 9483:HPGD
uniprot id: U3D0A5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:CRABP1
gene id: 9483:CRABP1
uniprot id: F7HB22
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:AOX1
gene id: 9483:AOX1
uniprot id: M1ZMR7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9483:LOC100411672
gene id: 9483:LOC100411672
uniprot id: A0A2R8MVQ0
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

9483:ACVR2A
gene id: 9483:ACVR2A
uniprot id: A0A5F4W6S4
uniprot id: F7AZW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9483:CHL1
gene id: 9483:CHL1
uniprot id: F6WU91
uniprot id: F6XG19
uniprot id: U3CMW1
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9483:CFAP299
gene id: 9483:CFAP299
uniprot id: F7HER8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

9483:ALDH4A1
gene id: 9483:ALDH4A1
uniprot id: F6ZZR3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:ANG
gene id: 9483:ANG
uniprot id: F7GKZ5
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9483:CD59
gene id: 9483:CD59
uniprot id: F6SUS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:TRHR
gene id: 9483:TRHR
uniprot id: F7HI57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9483:RDH5
gene id: 9483:RDH5
uniprot id: F7IBF6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:PPM1K
gene id: 9483:PPM1K
uniprot id: A0A8I3XBQ6
uniprot id: F7HI43
names: Similarity
messages: Belongs to the PP2C family.

9483:GBP5
gene id: 9483:GBP5
uniprot id: F7E8X1
uniprot id: U3CSZ8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9483:LTN1
gene id: 9483:LTN1
uniprot id: A0A2R8PEB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

9483:CA11
gene id: 9483:CA11
uniprot id: U3ARJ9
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9483:SEC11C
gene id: 9483:SEC11C
uniprot id: U3BJG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:KCND3
gene id: 9483:KCND3
uniprot id: U3C4J9
uniprot id: U3F539
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9483:SLC15A1
gene id: 9483:SLC15A1
uniprot id: F7IDU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9483:DYNC1I2
gene id: 9483:DYNC1I2
uniprot id: F6X617
uniprot id: F6XTS7
uniprot id: F6YXR6
uniprot id: U3E2W1
uniprot id: U3EU34
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9483:CMC4
gene id: 9483:CMC4
uniprot id: F6WXF4
names: Similarity
messages: Belongs to the CMC4 family.

9483:NETO1
gene id: 9483:NETO1
uniprot id: F7IEJ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MVB12A
gene id: 9483:MVB12A
uniprot id: U3CK21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9483:MOB3A
gene id: 9483:MOB3A
uniprot id: U3D0E7
names: Similarity
messages: Belongs to the MOB1/phocein family.

9483:SULF2
gene id: 9483:SULF2
uniprot id: U3D2G4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9483:INPP4B
gene id: 9483:INPP4B
uniprot id: F7IRC6
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9483:AP1S1
gene id: 9483:AP1S1
uniprot id: U3E0K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9483:RPL32
gene id: 9483:RPL32
uniprot id: A0A5F4WEM7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9483:STK4
gene id: 9483:STK4
uniprot id: U3C4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9483:NXPH1
gene id: 9483:NXPH1
uniprot id: U3ERP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9483:LOC100390657
gene id: 9483:LOC100390657
uniprot id: B0VX95
names: Subcellular Location Annotation
messages: Membrane

9483:CD79A
gene id: 9483:CD79A
uniprot id: F7AEC1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:CD68
gene id: 9483:CD68
uniprot id: U3FBS0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9483:PTCH2
gene id: 9483:PTCH2
uniprot id: U3E0M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9483:MEIG1
gene id: 9483:MEIG1
uniprot id: A0A8I3VV56
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9483:AGO4
gene id: 9483:AGO4
uniprot id: U3DZG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9483:ALDOC
gene id: 9483:ALDOC
uniprot id: F7I8Q1
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9483:VLDLR
gene id: 9483:VLDLR
uniprot id: F7HHP9
uniprot id: U3C8C5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CHPF
gene id: 9483:CHPF
uniprot id: B0KWJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9483:POP5
gene id: 9483:POP5
uniprot id: F7ITC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9483:ETNPPL
gene id: 9483:ETNPPL
uniprot id: A0A5F4W855
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9483:COPS7A
gene id: 9483:COPS7A
uniprot id: U3DCD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9483:IL1F10
gene id: 9483:IL1F10
uniprot id: F7CCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9483:DIMT1
gene id: 9483:DIMT1
uniprot id: U3FN76
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9483:GPR101
gene id: 9483:GPR101
uniprot id: F7I257
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:SPSB2
gene id: 9483:SPSB2
uniprot id: F7AY68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9483:SLC12A3
gene id: 9483:SLC12A3
uniprot id: F7IPQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9483:IER5
gene id: 9483:IER5
uniprot id: F7G7P3
names: Similarity
messages: Belongs to the IER family.

9483:FAM199X
gene id: 9483:FAM199X
uniprot id: F7GPT7
names: Similarity
messages: Belongs to the FAM199 family.

9483:CCL21
gene id: 9483:CCL21
uniprot id: F7B701
names: Subcellular Location Annotation
messages: Secreted

9483:DEFB123
gene id: 9483:DEFB123
uniprot id: A0A8I3W278
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:S100A10
gene id: 9483:S100A10
uniprot id: F7FGI3
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9483:TSPYL4
gene id: 9483:TSPYL4
uniprot id: U3FHE0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:GADL1
gene id: 9483:GADL1
uniprot id: U3DGB7
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9483:ERCC3
gene id: 9483:ERCC3
uniprot id: U3CZS4
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9483:LOC100387518
gene id: 9483:LOC100387518
uniprot id: A0A2R8P242
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9483:XPR1
gene id: 9483:XPR1
uniprot id: U3C4S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

9483:LOC100390661
gene id: 9483:LOC100390661
uniprot id: A0A5F4WD95
names: Similarity
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.

9483:ARHGEF6
gene id: 9483:ARHGEF6
uniprot id: U3DIW2
names: Subcellular Location Annotation
messages: lamellipodium

9483:MFN1
gene id: 9483:MFN1
uniprot id: U3FX89
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9483:SLC16A3
gene id: 9483:SLC16A3
uniprot id: F6U4G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9483:PMP22
gene id: 9483:PMP22
uniprot id: F7HND7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

9483:ASB9
gene id: 9483:ASB9
uniprot id: F6S5G6
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:MRPL12
gene id: 9483:MRPL12
uniprot id: F7HX78
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9483:TRAK2
gene id: 9483:TRAK2
uniprot id: U3FJ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9483:AQP7
gene id: 9483:AQP7
uniprot id: U3CSN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:FLOT2
gene id: 9483:FLOT2
uniprot id: U3CGZ2
uniprot id: U3FTR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9483:OTULINL
gene id: 9483:OTULINL
uniprot id: A0A8I3W553
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9483:SF3B1
gene id: 9483:SF3B1
uniprot id: F6R058
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9483:G6PC3
gene id: 9483:G6PC3
uniprot id: F6PJG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9483:CANT1
gene id: 9483:CANT1
uniprot id: F7D6T0
names: Similarity
messages: Belongs to the apyrase family.

9483:LOC100413069
gene id: 9483:LOC100413069
uniprot id: A0A8I3WQR7
names: Similarity
messages: Belongs to the SPAN-X family.

9483:NT5C3A
gene id: 9483:NT5C3A
uniprot id: F7B495
uniprot id: F7GS71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9483:B3GAT1
gene id: 9483:B3GAT1
uniprot id: A0A5K1UD53
uniprot id: U3DLU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:HTR2B
gene id: 9483:HTR2B
uniprot id: F6U6Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9483:LIPT1
gene id: 9483:LIPT1
uniprot id: F6UBC6
names: Similarity
messages: Belongs to the LplA family.

9483:LRP5
gene id: 9483:LRP5
uniprot id: U3D8R2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:FGFBP2
gene id: 9483:FGFBP2
uniprot id: A0A8I3VWG8
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9483:SCN1B
gene id: 9483:SCN1B
uniprot id: F6Y804
names: Subcellular Location Annotation
messages: Membrane

9483:SYNJ1
gene id: 9483:SYNJ1
uniprot id: F6XBI3
uniprot id: F7GAV4
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9483:PLA2G4A
gene id: 9483:PLA2G4A
uniprot id: A0A8J8Y9K6
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9483:ABCE1
gene id: 9483:ABCE1
uniprot id: U3FUZ0
names: Subunit
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

9483:PRDX1
gene id: 9483:PRDX1
uniprot id: F7IHK8
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9483:ALDOA
gene id: 9483:ALDOA
uniprot id: F6ZQC9
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9483:ELOC
gene id: 9483:ELOC
uniprot id: U3DRH8
names: Similarity
messages: Belongs to the SKP1 family.

9483:RAB14
gene id: 9483:RAB14
uniprot id: F7BFK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9483:LOC103787267
gene id: 9483:LOC103787267
uniprot id: B0KWA5
names: Similarity
messages: Belongs to the KHDC1 family.

9483:LOC100394089
gene id: 9483:LOC100394089
uniprot id: F7BE03
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9483:S1PR1
gene id: 9483:S1PR1
uniprot id: F7HBI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:UBN1
gene id: 9483:UBN1
uniprot id: A0A5F4WG95
uniprot id: F7CG91
uniprot id: F7CGB1
uniprot id: U3DNI9
names: Similarity
messages: Belongs to the ubinuclein family.

9483:LOC100395473
gene id: 9483:LOC100395473
uniprot id: H9KWM8
names: Similarity
messages: Belongs to the GAGE family.

9483:RNH1
gene id: 9483:RNH1
uniprot id: F7HNE6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

9483:TFIP11
gene id: 9483:TFIP11
uniprot id: F6YQH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9483:TLR3
gene id: 9483:TLR3
uniprot id: F7I1W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9483:FAM32A
gene id: 9483:FAM32A
uniprot id: U3D055
names: Similarity
messages: Belongs to the FAM32 family.

9483:LAMC1
gene id: 9483:LAMC1
uniprot id: U3CXM9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9483:SUDS3
gene id: 9483:SUDS3
uniprot id: A0A8I4A0J6
names: Subcellular Location Annotation
messages: Nucleus

9483:KCNS2
gene id: 9483:KCNS2
uniprot id: A0A2R8MYD8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:BCCIP
gene id: 9483:BCCIP
uniprot id: F7I620
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

9483:TTR
gene id: 9483:TTR
uniprot id: H1AAP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9483:MOV10
gene id: 9483:MOV10
uniprot id: F6UZ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9483:VRK1
gene id: 9483:VRK1
uniprot id: A0A5F4W549
uniprot id: U3E880
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:LOC100404525
gene id: 9483:LOC100404525
uniprot id: F7FTX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9483:TBX15
gene id: 9483:TBX15
uniprot id: A0A2R8PB87
uniprot id: F7HZ49
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:DNAJB12
gene id: 9483:DNAJB12
uniprot id: F7CSU9
uniprot id: U3DLP5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:POLR3K
gene id: 9483:POLR3K
uniprot id: B0VX71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9483:TMEM182
gene id: 9483:TMEM182
uniprot id: A0A2R8P5M8
uniprot id: A0A5F4WM85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9483:NDUFA3
gene id: 9483:NDUFA3
uniprot id: F6XMD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9483:ABCB9
gene id: 9483:ABCB9
uniprot id: U3E6C0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

9483:ERMN
gene id: 9483:ERMN
uniprot id: A0A8I3WEY0
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9483:SEC62
gene id: 9483:SEC62
uniprot id: F7C318
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:NFIB
gene id: 9483:NFIB
uniprot id: A0A2R8MJS4
uniprot id: F6XMK2
uniprot id: F6YSB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9483:GET1
gene id: 9483:GET1
uniprot id: B0KW89
uniprot id: F7ISC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:KCNN3
gene id: 9483:KCNN3
uniprot id: F7I0V2
names: Subcellular Location Annotation
messages: Membrane

9483:MTRF1
gene id: 9483:MTRF1
uniprot id: F7GQR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9483:DGKE
gene id: 9483:DGKE
uniprot id: U3DBL3
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9483:TAS1R2
gene id: 9483:TAS1R2
uniprot id: F6VWQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:UTP15
gene id: 9483:UTP15
uniprot id: U3ANT8
names: Subcellular Location Annotation
messages: nucleolus

9483:PSMA4
gene id: 9483:PSMA4
uniprot id: U3EX30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:KATNA1
gene id: 9483:KATNA1
uniprot id: F7HIN0
uniprot id: U3FQJ4
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

9483:GTF2F1
gene id: 9483:GTF2F1
uniprot id: U3CYN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

9483:LPL
gene id: 9483:LPL
uniprot id: F7HXL1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9483:DYRK3
gene id: 9483:DYRK3
uniprot id: F7IFK0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9483:C11H11orf58
gene id: 9483:C11H11orf58
uniprot id: F7HVS5
names: Similarity
messages: Belongs to the SMAP family.

9483:MAGOH
gene id: 9483:MAGOH
uniprot id: F7ID78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9483:POLH
gene id: 9483:POLH
uniprot id: F7HZ00
names: Subcellular Location Annotation
messages: Nucleus

9483:PDK1
gene id: 9483:PDK1
uniprot id: U3FE81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9483:ZSCAN25
gene id: 9483:ZSCAN25
uniprot id: F7IRV2
names: Subcellular Location Annotation
messages: Nucleus

9483:USP48
gene id: 9483:USP48
uniprot id: U3BS81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

9483:CTNS
gene id: 9483:CTNS
uniprot id: U3FGV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9483:NSUN4
gene id: 9483:NSUN4
uniprot id: F7HD16
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9483:HYCC2
gene id: 9483:HYCC2
uniprot id: A0A2R8MZ64
uniprot id: A0A8I4A4C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9483:PRKX
gene id: 9483:PRKX
uniprot id: U3BK70
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:LOC103793463
gene id: 9483:LOC103793463
uniprot id: A0A2R8MGA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:TBX5
gene id: 9483:TBX5
uniprot id: F7I9S7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:SLC41A1
gene id: 9483:SLC41A1
uniprot id: F7FY35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9483:LOC100399888
gene id: 9483:LOC100399888
uniprot id: F7GHA7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SRP9
gene id: 9483:SRP9
uniprot id: F7IIG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9483:CNTNAP4
gene id: 9483:CNTNAP4
uniprot id: U3FWU7
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SIAH2
gene id: 9483:SIAH2
uniprot id: F7I4Z0
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9483:TMEM208
gene id: 9483:TMEM208
uniprot id: U3C559
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9483:ARL1
gene id: 9483:ARL1
uniprot id: F6VEE2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9483:SLC26A7
gene id: 9483:SLC26A7
uniprot id: F7G2J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9483:ISY1
gene id: 9483:ISY1
uniprot id: U3D161
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9483:THOC6
gene id: 9483:THOC6
uniprot id: U3C1X1
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9483:GCDH
gene id: 9483:GCDH
uniprot id: F7IF96
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9483:ACTL6B
gene id: 9483:ACTL6B
uniprot id: F7FRF7
names: Similarity
messages: Belongs to the actin family.

9483:MRRF
gene id: 9483:MRRF
uniprot id: A0A2R8M7C8
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9483:LOC100393733
gene id: 9483:LOC100393733
uniprot id: A0A5F4VY33
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9483:ZUP1
gene id: 9483:ZUP1
uniprot id: U3DBX6
uniprot id: U3EEL3
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9483:FAM187B
gene id: 9483:FAM187B
uniprot id: F6SRZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9483:HSBP1
gene id: 9483:HSBP1
uniprot id: A0A2R8PF30
names: Similarity
messages: Belongs to the HSBP1 family.

9483:GPR182
gene id: 9483:GPR182
uniprot id: F6QCH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PRKCB
gene id: 9483:PRKCB
uniprot id: U3EAU9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9483:ACOT13
gene id: 9483:ACOT13
uniprot id: F7IQA2
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9483:DUSP29
gene id: 9483:DUSP29
uniprot id: F7IJ24
uniprot id: U3DS87
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9483:ADPRH
gene id: 9483:ADPRH
uniprot id: F6YNG9
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9483:BEST3
gene id: 9483:BEST3
uniprot id: U3DSN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9483:TMEM192
gene id: 9483:TMEM192
uniprot id: A0A2R8MKT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9483:PRPF38A
gene id: 9483:PRPF38A
uniprot id: U3FEZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9483:TAF6
gene id: 9483:TAF6
uniprot id: F7BUA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9483:TRIM55
gene id: 9483:TRIM55
uniprot id: U3DH77
uniprot id: U3E739
names: Subcellular Location Annotation
messages: Cytoplasm

9483:KCNJ3
gene id: 9483:KCNJ3
uniprot id: F7AN67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9483:HTRA3
gene id: 9483:HTRA3
uniprot id: A0A8I3WX49
uniprot id: F7CCB8
names: Similarity
messages: Belongs to the peptidase S1C family.

9483:SERPINE2
gene id: 9483:SERPINE2
uniprot id: F7I8D6
names: Similarity
messages: Belongs to the serpin family.

9483:ACAD10
gene id: 9483:ACAD10
uniprot id: F6SQR9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9483:PGD
gene id: 9483:PGD
uniprot id: U3CWW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9483:GNPDA2
gene id: 9483:GNPDA2
uniprot id: A0A5F4W7E7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9483:CMTM8
gene id: 9483:CMTM8
uniprot id: U3F7P3
names: Subcellular Location Annotation
messages: Membrane

9483:ADAM22
gene id: 9483:ADAM22
uniprot id: A0A2R8MSI5
uniprot id: A0A8I3W746
uniprot id: A0A8J8XKU3
uniprot id: F7IT50
uniprot id: U3DZK3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:UIMC1
gene id: 9483:UIMC1
uniprot id: U3CM25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

9483:PCK2
gene id: 9483:PCK2
uniprot id: F7CT55
names: Similarity
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Monomer.

9483:HTRA1
gene id: 9483:HTRA1
uniprot id: U3F3W6
names: Similarity
messages: Belongs to the peptidase S1C family.

9483:UNC13D
gene id: 9483:UNC13D
uniprot id: A0A8I4A115
names: Similarity
messages: Belongs to the unc-13 family.

9483:SLCO1C1
gene id: 9483:SLCO1C1
uniprot id: A0A8I3XAJ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:LAP3
gene id: 9483:LAP3
uniprot id: F7IIB5
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9483:CYP1A2
gene id: 9483:CYP1A2
uniprot id: O77810
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.
messages: Microsome membrane

9483:SNAP25
gene id: 9483:SNAP25
uniprot id: U3DAS2
uniprot id: U3DKT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9483:CYB5RL
gene id: 9483:CYB5RL
uniprot id: U3BEP3
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9483:PALMD
gene id: 9483:PALMD
uniprot id: U3EDL0
names: Similarity
messages: Belongs to the paralemmin family.

9483:MCM7
gene id: 9483:MCM7
uniprot id: F7ALH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9483:ARG2
gene id: 9483:ARG2
uniprot id: F7A825
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9483:LOC100393645
gene id: 9483:LOC100393645
uniprot id: F7IEU2
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9483:GNG4
gene id: 9483:GNG4
uniprot id: F6QSV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:PPP4R2
gene id: 9483:PPP4R2
uniprot id: U3D0Z9
names: Similarity
messages: Belongs to the PPP4R2 family.

9483:POPDC3
gene id: 9483:POPDC3
uniprot id: F7GHY4
names: Similarity
messages: Belongs to the popeye family.

9483:ADPRHL1
gene id: 9483:ADPRHL1
uniprot id: F6PXM0
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9483:FMR1
gene id: 9483:FMR1
uniprot id: A0A2R8MBF6
uniprot id: U3CRA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9483:KYNU
gene id: 9483:KYNU
uniprot id: F6YX40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PSMD8
gene id: 9483:PSMD8
uniprot id: U3DPY5
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

9483:LOC108588476
gene id: 9483:LOC108588476
uniprot id: A0A8I3W3L4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:TMSB15A
gene id: 9483:TMSB15A
uniprot id: F7ILT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9483:ZNF446
gene id: 9483:ZNF446
uniprot id: A0A5F4VTG5
names: Subcellular Location Annotation
messages: Nucleus

9483:CXCL14
gene id: 9483:CXCL14
uniprot id: A0A8I3WNC3
names: Subcellular Location Annotation
messages: Secreted

9483:CEP170
gene id: 9483:CEP170
uniprot id: U3BXG4
uniprot id: U3CHE7
uniprot id: U3E724
names: Similarity
messages: Belongs to the CEP170 family.

9483:ATG5
gene id: 9483:ATG5
uniprot id: A0A2R8M348
uniprot id: A0A2R8ML30
uniprot id: A0A8I3WPZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9483:FAM135A
gene id: 9483:FAM135A
uniprot id: A0A2R8MX13
uniprot id: A0A8I3W5F0
uniprot id: F7DGS6
uniprot id: U3C872
names: Similarity
messages: Belongs to the FAM135 family.

9483:PGAP2
gene id: 9483:PGAP2
uniprot id: U3EUI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9483:NPAS3
gene id: 9483:NPAS3
uniprot id: A0A2R8M666
names: Subcellular Location Annotation
messages: Nucleus

9483:DCP1A
gene id: 9483:DCP1A
uniprot id: U3D2Q4
names: Similarity
messages: Belongs to the DCP1 family.

9483:RNF121
gene id: 9483:RNF121
uniprot id: F6WTX2
names: Subcellular Location Annotation
messages: Membrane

9483:MYT1L
gene id: 9483:MYT1L
uniprot id: A0A5F4VSN3
uniprot id: F7CCJ7
uniprot id: F7CCX3
uniprot id: U3F544
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9483:B3GALT5
gene id: 9483:B3GALT5
uniprot id: F6YSH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:CYP2C18
gene id: 9483:CYP2C18
uniprot id: A0A171P0Y7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:TPPP2
gene id: 9483:TPPP2
uniprot id: F7IA21
names: Similarity
messages: Belongs to the TPPP family.

9483:TJP2
gene id: 9483:TJP2
uniprot id: U3CA71
uniprot id: U3CSI5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9483:FLNB
gene id: 9483:FLNB
uniprot id: A0A8J8XD29
uniprot id: A0A8J8Y4Q1
uniprot id: U3DG44
names: Similarity
messages: Belongs to the filamin family.

9483:MRPL43
gene id: 9483:MRPL43
uniprot id: U3E5Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9483:YME1L1
gene id: 9483:YME1L1
uniprot id: U3BKR7
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9483:TAMM41
gene id: 9483:TAMM41
uniprot id: A0A2R8MH54
uniprot id: F7BR22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9483:SERPING1
gene id: 9483:SERPING1
uniprot id: F7B8K7
names: Similarity
messages: Belongs to the serpin family.

9483:FAN1
gene id: 9483:FAN1
uniprot id: U3DBA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

9483:PTAFR
gene id: 9483:PTAFR
uniprot id: F7IRI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9483:SARS1
gene id: 9483:SARS1
uniprot id: A0A2R8NFA7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9483:FIGNL1
gene id: 9483:FIGNL1
uniprot id: F7H702
names: Similarity
messages: Belongs to the AAA ATPase family.

9483:WASF2
gene id: 9483:WASF2
uniprot id: F7BLL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9483:SIN3A
gene id: 9483:SIN3A
uniprot id: F7A408
names: Subcellular Location Annotation
messages: Nucleus

9483:BRMS1
gene id: 9483:BRMS1
uniprot id: F7ISX8
names: Subcellular Location Annotation
messages: Nucleus

9483:LHFPL4
gene id: 9483:LHFPL4
uniprot id: F7IP59
names: Subcellular Location Annotation
messages: Membrane

9483:ANKRD13D
gene id: 9483:ANKRD13D
uniprot id: U3CBJ2
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9483:NXPH2
gene id: 9483:NXPH2
uniprot id: A0A8I3WVL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9483:NR1H4
gene id: 9483:NR1H4
uniprot id: A0A2R8MU47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9483:EIF4EBP3
gene id: 9483:EIF4EBP3
uniprot id: F7CJA3
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9483:NUBP1
gene id: 9483:NUBP1
uniprot id: F7HS53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

9483:LIPA
gene id: 9483:LIPA
uniprot id: F6QJ20
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9483:S1PR2
gene id: 9483:S1PR2
uniprot id: F7H567
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC100415308
gene id: 9483:LOC100415308
uniprot id: J9QRH9
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9483:SPOUT1
gene id: 9483:SPOUT1
uniprot id: B0KWE0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

9483:SERPINH1
gene id: 9483:SERPINH1
uniprot id: F6WJ59
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

9483:TSPAN13
gene id: 9483:TSPAN13
uniprot id: F7HX26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:CPS1
gene id: 9483:CPS1
uniprot id: F7G8E2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PAIP2B
gene id: 9483:PAIP2B
uniprot id: U3FGY1
names: Similarity
messages: Belongs to the PAIP2 family.

9483:ATP1A1
gene id: 9483:ATP1A1
uniprot id: A0A8I4A1I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9483:URAD
gene id: 9483:URAD
uniprot id: F7GNJ9
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9483:MYH10
gene id: 9483:MYH10
uniprot id: F7I9C3
uniprot id: U3D4N5
uniprot id: U3EDP2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:RNASE4
gene id: 9483:RNASE4
uniprot id: A0A2R8MAQ1
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9483:OR13J1
gene id: 9483:OR13J1
uniprot id: A0A5F4WC48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TMEM258
gene id: 9483:TMEM258
uniprot id: F7GXA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9483:RNF152
gene id: 9483:RNF152
uniprot id: F7HAL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

9483:SIM1
gene id: 9483:SIM1
uniprot id: F7HZQ9
names: Subcellular Location Annotation
messages: Nucleus

9483:CLDN3
gene id: 9483:CLDN3
uniprot id: F7BNR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:WSCD1
gene id: 9483:WSCD1
uniprot id: F7I403
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Golgi apparatus membrane
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9483:TMCC3
gene id: 9483:TMCC3
uniprot id: F7ICJ2
names: Similarity
messages: Belongs to the TEX28 family.

9483:CALR
gene id: 9483:CALR
uniprot id: F7I5Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9483:GATA2
gene id: 9483:GATA2
uniprot id: F7HXJ7
names: Subcellular Location Annotation
messages: Nucleus

9483:LIPM
gene id: 9483:LIPM
uniprot id: A0A8I3WDX7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9483:LOC100398424
gene id: 9483:LOC100398424
uniprot id: A0A8I3WLK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:TRAPPC6B
gene id: 9483:TRAPPC6B
uniprot id: U3AR63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9483:FOLR1
gene id: 9483:FOLR1
uniprot id: A0A2R8MPG7
names: Similarity
messages: Belongs to the folate receptor family.

9483:FN3K
gene id: 9483:FN3K
uniprot id: F6U657
names: Similarity
messages: Belongs to the fructosamine kinase family.

9483:LOC100406262
gene id: 9483:LOC100406262
uniprot id: B0VX86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TAC3
gene id: 9483:TAC3
uniprot id: F6QN68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9483:NDRG1
gene id: 9483:NDRG1
uniprot id: U3C0J9
names: Similarity
messages: Belongs to the NDRG family.

9483:NUP50
gene id: 9483:NUP50
uniprot id: F7IC26
names: Subcellular Location Annotation
messages: nuclear pore complex

9483:RRM2
gene id: 9483:RRM2
uniprot id: F7GFM3
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9483:GCAT
gene id: 9483:GCAT
uniprot id: U3ECL4
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9483:B9D2
gene id: 9483:B9D2
uniprot id: F7BH58
names: Subcellular Location Annotation
messages: cilium basal body

9483:OR51B6
gene id: 9483:OR51B6
uniprot id: A0A5F4VVN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:EDEM2
gene id: 9483:EDEM2
uniprot id: F6TUE0
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9483:UBR1
gene id: 9483:UBR1
uniprot id: U3EWC6
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9483:NAA11
gene id: 9483:NAA11
uniprot id: F7DDU0
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9483:ALOX12
gene id: 9483:ALOX12
uniprot id: U3B0U1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PFDN2
gene id: 9483:PFDN2
uniprot id: F7F6X9
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9483:LOC100409982
gene id: 9483:LOC100409982
uniprot id: U3CM30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:PAPOLG
gene id: 9483:PAPOLG
uniprot id: U3FHB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

9483:LOC100409364
gene id: 9483:LOC100409364
uniprot id: F7IF34
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9483:NEURL2
gene id: 9483:NEURL2
uniprot id: F7I9Z1
names: Subcellular Location Annotation
messages: Cytoplasm

9483:GHR
gene id: 9483:GHR
uniprot id: A0A5F4WE18
uniprot id: A0A8I3WN21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

9483:OS9
gene id: 9483:OS9
uniprot id: U3CKK0
uniprot id: U3D7F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9483:FAM83G
gene id: 9483:FAM83G
uniprot id: U3BLH7
names: Similarity
messages: Belongs to the FAM83 family.

9483:IL17F
gene id: 9483:IL17F
uniprot id: A6N6I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-17 family.
messages: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway. Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes.
messages: Homodimer; disulfide-linked (By similarity). Heterodimer with IL17A (IL17A-IL17F) (By similarity). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule. IL17F homodimer forms predominantly complexes with IL17RC homodimer, whereas IL17A-IL17F favors complexes with IL17RA-IL17RC. IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (By similarity).
messages: Secreted

9483:LDHAL6B
gene id: 9483:LDHAL6B
uniprot id: A0A5F4W344
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9483:SPRYD4
gene id: 9483:SPRYD4
uniprot id: F7D4Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:NECAP2
gene id: 9483:NECAP2
uniprot id: F7DFK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9483:MOB1A
gene id: 9483:MOB1A
uniprot id: F7H5V9
names: Similarity
messages: Belongs to the MOB1/phocein family.

9483:DKK1
gene id: 9483:DKK1
uniprot id: F7IQ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9483:BEX5
gene id: 9483:BEX5
uniprot id: F6V5P7
names: Similarity
messages: Belongs to the BEX family.

9483:CFAP69
gene id: 9483:CFAP69
uniprot id: B0VXE6
names: Function
names: Subcellular Location Annotation
messages: Cilium- and flagellum-associated protein (By similarity). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability (By similarity).
messages: cilium
messages: flagellum

9483:TP53I11
gene id: 9483:TP53I11
uniprot id: U3CZ55
names: Subcellular Location Annotation
messages: Membrane

9483:CYBA
gene id: 9483:CYBA
uniprot id: U3EKP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9483:GRM1
gene id: 9483:GRM1
uniprot id: F7E693
uniprot id: F7E6E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9483:LOC100385973
gene id: 9483:LOC100385973
uniprot id: A0A2R8M646
names: Similarity
messages: Belongs to the HINT family.

9483:PTGS2
gene id: 9483:PTGS2
uniprot id: U3DE75
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TNRC6C
gene id: 9483:TNRC6C
uniprot id: U3FAC6
names: Similarity
messages: Belongs to the GW182 family.

9483:SNX11
gene id: 9483:SNX11
uniprot id: U3E8B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9483:LOC100394098
gene id: 9483:LOC100394098
uniprot id: F7HDB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:APEX1
gene id: 9483:APEX1
uniprot id: U3F4F7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9483:OXSR1
gene id: 9483:OXSR1
uniprot id: U3BQ56
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9483:GAREM1
gene id: 9483:GAREM1
uniprot id: U3EBM3
names: Similarity
messages: Belongs to the GAREM family.

9483:LOC103790833
gene id: 9483:LOC103790833
uniprot id: F7C9D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9483:ZSCAN9
gene id: 9483:ZSCAN9
uniprot id: U3CI98
names: Subcellular Location Annotation
messages: Nucleus

9483:TBX3
gene id: 9483:TBX3
uniprot id: F7HRE2
uniprot id: F7I557
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:ZP4
gene id: 9483:ZP4
uniprot id: P79159
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Zona pellucida

9483:TCEANC2
gene id: 9483:TCEANC2
uniprot id: U3FF24
names: Subcellular Location Annotation
messages: Nucleus

9483:STX19
gene id: 9483:STX19
uniprot id: A0A5F4VYQ5
names: Similarity
messages: Belongs to the syntaxin family.

9483:RNASE3
gene id: 9483:RNASE3
uniprot id: F7HVT5
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9483:CDH6
gene id: 9483:CDH6
uniprot id: F7IMY6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:GALNT13
gene id: 9483:GALNT13
uniprot id: U3BX46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:WDR46
gene id: 9483:WDR46
uniprot id: U3D6H3
names: Subcellular Location Annotation
messages: nucleolus

9483:CD9
gene id: 9483:CD9
uniprot id: U3DYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

9483:FUT10
gene id: 9483:FUT10
uniprot id: U3EP63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9483:LOC100412562
gene id: 9483:LOC100412562
uniprot id: A0A7G0X101
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9483:TLR10
gene id: 9483:TLR10
uniprot id: F6X6W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9483:ARL11
gene id: 9483:ARL11
uniprot id: F7HAY2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9483:GDE1
gene id: 9483:GDE1
uniprot id: F7I4Y1
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9483:SLC35C2
gene id: 9483:SLC35C2
uniprot id: U3BE49
names: Subcellular Location Annotation
messages: Membrane

9483:ZDHHC15
gene id: 9483:ZDHHC15
uniprot id: A0A8I3W786
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:HBEGF
gene id: 9483:HBEGF
uniprot id: U3DCM7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:KCNH8
gene id: 9483:KCNH8
uniprot id: F7F3H8
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9483:LOC100395561
gene id: 9483:LOC100395561
uniprot id: F7BIZ6
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9483:NKX2-1
gene id: 9483:NKX2-1
uniprot id: F6R3N0
names: Subcellular Location Annotation
messages: Nucleus

9483:MDFIC
gene id: 9483:MDFIC
uniprot id: F7ICM6
names: Similarity
messages: Belongs to the MDFI family.

9483:ALDH1A3
gene id: 9483:ALDH1A3
uniprot id: A0A8J8YLV6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:GALNTL6
gene id: 9483:GALNTL6
uniprot id: U3BZQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:LSM8
gene id: 9483:LSM8
uniprot id: A0A8I3WM72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9483:IRF1
gene id: 9483:IRF1
uniprot id: B0KWP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9483:CCL20
gene id: 9483:CCL20
uniprot id: U3CWL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:SRPRA
gene id: 9483:SRPRA
uniprot id: U3E4N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:STRN
gene id: 9483:STRN
uniprot id: F7GIV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9483:LOC100396934
gene id: 9483:LOC100396934
uniprot id: F7IIN0
names: Similarity
messages: Belongs to the Bcl-2 family.

9483:TMEM200C
gene id: 9483:TMEM200C
uniprot id: U3D7K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9483:CYRIB
gene id: 9483:CYRIB
uniprot id: U3F8K8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9483:PFKFB3
gene id: 9483:PFKFB3
uniprot id: A0A8I3W439
uniprot id: F6WMF5
uniprot id: F7INK2
uniprot id: F7INK3
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9483:SARAF
gene id: 9483:SARAF
uniprot id: U3E7B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9483:LOC100414136
gene id: 9483:LOC100414136
uniprot id: F6VLK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

9483:MED19
gene id: 9483:MED19
uniprot id: F7EJX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:CPNE8
gene id: 9483:CPNE8
uniprot id: F6RB22
names: Similarity
messages: Belongs to the copine family.

9483:SLC22A4
gene id: 9483:SLC22A4
uniprot id: F7EVG4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9483:TYROBP
gene id: 9483:TYROBP
uniprot id: U3CY64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9483:LYRM4
gene id: 9483:LYRM4
uniprot id: U3DUB0
names: Similarity
messages: Belongs to the complex I LYR family.

9483:HNRNPU
gene id: 9483:HNRNPU
uniprot id: U3EE83
uniprot id: U3F263
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:OR6X1
gene id: 9483:OR6X1
uniprot id: F7GP36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9483:ELOVL3
gene id: 9483:ELOVL3
uniprot id: A0A8I3VZ93
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9483:IL13
gene id: 9483:IL13
uniprot id: B0KWP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-4/IL-13 family.
messages: Interacts with IL13RA2.
messages: Secreted

9483:PYGB
gene id: 9483:PYGB
uniprot id: U3DDL5
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9483:KATNB1
gene id: 9483:KATNB1
uniprot id: U3CR17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9483:BSPRY
gene id: 9483:BSPRY
uniprot id: F6PLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:PHF1
gene id: 9483:PHF1
uniprot id: F7IR10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9483:UTP11
gene id: 9483:UTP11
uniprot id: U3FHA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9483:STON2
gene id: 9483:STON2
uniprot id: A0A2R8N120
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

9483:PKMYT1
gene id: 9483:PKMYT1
uniprot id: U3CWB5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:ME2
gene id: 9483:ME2
uniprot id: U3EUL8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9483:BICD2
gene id: 9483:BICD2
uniprot id: A0A8J8XD79
names: Similarity
messages: Belongs to the BicD family.

9483:YARS1
gene id: 9483:YARS1
uniprot id: F6ZN82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

9483:PLN
gene id: 9483:PLN
uniprot id: F6TR48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

9483:PDGFC
gene id: 9483:PDGFC
uniprot id: A0A8I3W9P2
uniprot id: F7HUW5
uniprot id: U3DUG3
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ELL3
gene id: 9483:ELL3
uniprot id: B0KWG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9483:MTG2
gene id: 9483:MTG2
uniprot id: A0A5F4W3X9
uniprot id: F7HV74
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9483:NDUFB6
gene id: 9483:NDUFB6
uniprot id: U3BMW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:SPRTN
gene id: 9483:SPRTN
uniprot id: U3C485
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9483:LOC100403393
gene id: 9483:LOC100403393
uniprot id: U3CN13
names: Similarity
messages: Belongs to the cytochrome b5 family.

9483:PTGER4
gene id: 9483:PTGER4
uniprot id: F6VDJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9483:RIC8B
gene id: 9483:RIC8B
uniprot id: A0A2R8MZC9
uniprot id: A0A8I3W764
uniprot id: F7H9Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9483:NDUFB5
gene id: 9483:NDUFB5
uniprot id: F7GBY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:MRPL16
gene id: 9483:MRPL16
uniprot id: F6SEU8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9483:MRTO4
gene id: 9483:MRTO4
uniprot id: F6QB78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

9483:SMARCAL1
gene id: 9483:SMARCAL1
uniprot id: A0A5K1TUB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9483:SPSB4
gene id: 9483:SPSB4
uniprot id: F7E873
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9483:SUGP1
gene id: 9483:SUGP1
uniprot id: U3E6Y9
names: Subcellular Location Annotation
messages: Nucleus

9483:MRGPRF
gene id: 9483:MRGPRF
uniprot id: U3ANU3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:SNRPG
gene id: 9483:SNRPG
uniprot id: U3EIA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9483:NUDT21
gene id: 9483:NUDT21
uniprot id: F7I8U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

9483:GJA4
gene id: 9483:GJA4
uniprot id: F7ARL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:FN1
gene id: 9483:FN1
uniprot id: F7HU65
uniprot id: F7HWU2
uniprot id: F7ISE9
uniprot id: U3DSP4
uniprot id: U3EWW1
names: Function
messages: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.

9483:TAF11
gene id: 9483:TAF11
uniprot id: F7A607
uniprot id: F7IMF2
names: Similarity
messages: Belongs to the TAF11 family.

9483:MRPS36
gene id: 9483:MRPS36
uniprot id: F7HY63
names: Subcellular Location Annotation
messages: Mitochondrion

9483:SLC26A4
gene id: 9483:SLC26A4
uniprot id: F6WCD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

9483:ACVR1B
gene id: 9483:ACVR1B
uniprot id: U3C5A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9483:PROM1
gene id: 9483:PROM1
uniprot id: A0A5F4W3J4
uniprot id: A0A5F4W6B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9483:RPE
gene id: 9483:RPE
uniprot id: U3FH05
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9483:ADGRG6
gene id: 9483:ADGRG6
uniprot id: A0A8I3WLK5
uniprot id: F6QI92
uniprot id: F7IP60
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:USP21
gene id: 9483:USP21
uniprot id: F7EUN1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:RBM5
gene id: 9483:RBM5
uniprot id: A0A8I3WFJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9483:KPNA4
gene id: 9483:KPNA4
uniprot id: U3BW75
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9483:NUP88
gene id: 9483:NUP88
uniprot id: U3D2R2
names: Subcellular Location Annotation
messages: nuclear pore complex

9483:SPOP
gene id: 9483:SPOP
uniprot id: F6X846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9483:DPH6
gene id: 9483:DPH6
uniprot id: U3BM61
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9483:ERO1B
gene id: 9483:ERO1B
uniprot id: U3D8Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9483:MRPL58
gene id: 9483:MRPL58
uniprot id: F7HPD3
names: Subcellular Location Annotation
messages: Mitochondrion

9483:ADHFE1
gene id: 9483:ADHFE1
uniprot id: F7H822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9483:LOC100415560
gene id: 9483:LOC100415560
uniprot id: A0A8I3X6R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:GLRA3
gene id: 9483:GLRA3
uniprot id: F7GC00
uniprot id: F7GLH0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9483:BCAP29
gene id: 9483:BCAP29
uniprot id: F6RHI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9483:ZDHHC9
gene id: 9483:ZDHHC9
uniprot id: F7HP76
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:DDX5
gene id: 9483:DDX5
uniprot id: U3CNG4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9483:TFRC
gene id: 9483:TFRC
uniprot id: H9BFK5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

9483:ACTR8
gene id: 9483:ACTR8
uniprot id: U3CEX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9483:H1-5
gene id: 9483:H1-5
uniprot id: A0A2R8MFI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9483:RFC5
gene id: 9483:RFC5
uniprot id: U3BST5
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9483:SNRNP200
gene id: 9483:SNRNP200
uniprot id: F7IBV6
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9483:NDUFS5
gene id: 9483:NDUFS5
uniprot id: F7B8U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9483:CCR4
gene id: 9483:CCR4
uniprot id: F7F2B0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:COPB1
gene id: 9483:COPB1
uniprot id: F7GQX5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9483:CD28
gene id: 9483:CD28
uniprot id: A0A5F4VR83
uniprot id: A5HJL7
names: Subcellular Location Annotation
messages: Membrane

9483:ATG16L2
gene id: 9483:ATG16L2
uniprot id: F7GNX8
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9483:STXBP5
gene id: 9483:STXBP5
uniprot id: F7E5V3
uniprot id: F7GZ23
uniprot id: U3EYR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9483:ING3
gene id: 9483:ING3
uniprot id: U3BH34
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9483:ATP6V1H
gene id: 9483:ATP6V1H
uniprot id: U3BXQ6
uniprot id: U3CFY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9483:RPL38
gene id: 9483:RPL38
uniprot id: A0A5F4W0P3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9483:FAH
gene id: 9483:FAH
uniprot id: U3CEN7
names: Similarity
messages: Belongs to the FAH family.

9483:ATP2B1
gene id: 9483:ATP2B1
uniprot id: A0A8I3W2J7
uniprot id: F7E517
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:UCN
gene id: 9483:UCN
uniprot id: F7CU67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9483:CHST11
gene id: 9483:CHST11
uniprot id: F7F2M8
uniprot id: U3CLY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:PPP2R2A
gene id: 9483:PPP2R2A
uniprot id: U3CQ53
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9483:PKIB
gene id: 9483:PKIB
uniprot id: A0A5F4W598
uniprot id: A0A8I3X2R3
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9483:MPG
gene id: 9483:MPG
uniprot id: F6QTA1
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

9483:SMAD4
gene id: 9483:SMAD4
uniprot id: U3E3A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9483:CSMD3
gene id: 9483:CSMD3
uniprot id: F7IB61
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:C22H19orf53
gene id: 9483:C22H19orf53
uniprot id: F7AA03
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9483:MOXD1
gene id: 9483:MOXD1
uniprot id: B0KWA2
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9483:LTV1
gene id: 9483:LTV1
uniprot id: F7H7Q1
names: Similarity
messages: Belongs to the LTV1 family.

9483:LOC100389230
gene id: 9483:LOC100389230
uniprot id: A0A2R8MBA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9483:IFNL3
gene id: 9483:IFNL3
uniprot id: F7ACE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9483:LOC100388427
gene id: 9483:LOC100388427
uniprot id: F7FGL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:SLC25A53
gene id: 9483:SLC25A53
uniprot id: F7GUE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:REEP3
gene id: 9483:REEP3
uniprot id: F6ZYR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9483:DYNLRB1
gene id: 9483:DYNLRB1
uniprot id: F7IQZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9483:FOXI2
gene id: 9483:FOXI2
uniprot id: F7I4R5
names: Subcellular Location Annotation
messages: Nucleus

9483:EIF5A2
gene id: 9483:EIF5A2
uniprot id: F6YNW2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

9483:GNG12
gene id: 9483:GNG12
uniprot id: F7E106
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:PDE1B
gene id: 9483:PDE1B
uniprot id: A0A8I3WF54
uniprot id: F7ISI9
uniprot id: U3DNA4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:ICAM2
gene id: 9483:ICAM2
uniprot id: F7FBG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9483:PLA1A
gene id: 9483:PLA1A
uniprot id: A0A5F4VSD8
uniprot id: F7A5P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9483:CHIT1
gene id: 9483:CHIT1
uniprot id: F7H9D8
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9483:DDX24
gene id: 9483:DDX24
uniprot id: F6SWG1
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9483:RSL24D1
gene id: 9483:RSL24D1
uniprot id: A0A2R8MGE6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9483:UBE2K
gene id: 9483:UBE2K
uniprot id: F7HJ73
uniprot id: F7HJG5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:IRX6
gene id: 9483:IRX6
uniprot id: F7F8E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9483:SLC5A7
gene id: 9483:SLC5A7
uniprot id: F6ZJ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9483:SLC25A33
gene id: 9483:SLC25A33
uniprot id: U3E5R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:RSAD2
gene id: 9483:RSAD2
uniprot id: U3B8G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9483:ERP29
gene id: 9483:ERP29
uniprot id: F7C9F2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: Melanosome

9483:GGTA1
gene id: 9483:GGTA1
uniprot id: Q8SQ20
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Golgi stack membrane
messages: Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3) (By similarity).
messages: The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).

9483:TGIF1
gene id: 9483:TGIF1
uniprot id: A0A8I3WAA8
uniprot id: F7E4J0
names: Subcellular Location Annotation
messages: Nucleus

9483:SCAND3
gene id: 9483:SCAND3
uniprot id: F7IK96
names: Subcellular Location Annotation
messages: Nucleus

9483:SETDB2
gene id: 9483:SETDB2
uniprot id: U3D7Z6
names: Subcellular Location Annotation
messages: Chromosome

9483:CAPN7
gene id: 9483:CAPN7
uniprot id: F7D1T2
names: Similarity
messages: Belongs to the peptidase C2 family.

9483:TIMM8A
gene id: 9483:TIMM8A
uniprot id: U3D825
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9483:LOC100412910
gene id: 9483:LOC100412910
uniprot id: F7GP74
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9483:APOOL
gene id: 9483:APOOL
uniprot id: U3BZQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9483:LOC100414611
gene id: 9483:LOC100414611
uniprot id: A0A2R8M558
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:PPP6R2
gene id: 9483:PPP6R2
uniprot id: U3DCX6
names: Similarity
messages: Belongs to the SAPS family.

9483:TNP2
gene id: 9483:TNP2
uniprot id: A0A2R8PMU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: nucleolus

9483:NSUN6
gene id: 9483:NSUN6
uniprot id: F7EM71
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9483:DXO
gene id: 9483:DXO
uniprot id: F6XJ66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9483:CHRNB3
gene id: 9483:CHRNB3
uniprot id: F7IIU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:FAM168B
gene id: 9483:FAM168B
uniprot id: F7GKM9
names: Similarity
messages: Belongs to the FAM168 family.

9483:HSD17B2
gene id: 9483:HSD17B2
uniprot id: F6VR90
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:CCKBR
gene id: 9483:CCKBR
uniprot id: A0A2R8NCK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9483:SLC5A9
gene id: 9483:SLC5A9
uniprot id: U3BD27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9483:GIMAP7
gene id: 9483:GIMAP7
uniprot id: A0A8I3WYG6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9483:NDUFB9
gene id: 9483:NDUFB9
uniprot id: F6S3Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:CFL2
gene id: 9483:CFL2
uniprot id: F7DMB4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9483:LOC100402206
gene id: 9483:LOC100402206
uniprot id: A0A2R8PKP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:FAM219B
gene id: 9483:FAM219B
uniprot id: F7AKV0
names: Similarity
messages: Belongs to the FAM219 family.

9483:MRPL47
gene id: 9483:MRPL47
uniprot id: F7GBP5
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9483:NDUFA1
gene id: 9483:NDUFA1
uniprot id: F7HZE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:H1-4
gene id: 9483:H1-4
uniprot id: U3D8R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9483:LOC100406123
gene id: 9483:LOC100406123
uniprot id: F7I7Z9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:CENPO
gene id: 9483:CENPO
uniprot id: A0A2R8MYD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9483:WDR44
gene id: 9483:WDR44
uniprot id: U3E400
names: Subcellular Location Annotation
messages: trans-Golgi network

9483:SYNGR2
gene id: 9483:SYNGR2
uniprot id: F7H8R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9483:WASHC3
gene id: 9483:WASHC3
uniprot id: A0A8I4A1Z1
uniprot id: U3FE08
names: Similarity
messages: Belongs to the CCDC53 family.

9483:CNOT8
gene id: 9483:CNOT8
uniprot id: F7HP79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9483:S100A2
gene id: 9483:S100A2
uniprot id: F6ZM10
names: Similarity
messages: Belongs to the S-100 family.

9483:MTMR9
gene id: 9483:MTMR9
uniprot id: A0A2R8M2R3
uniprot id: A0A5F4WMP3
uniprot id: F7H906
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9483:PIGW
gene id: 9483:PIGW
uniprot id: U3DL47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

9483:ARL5A
gene id: 9483:ARL5A
uniprot id: F7FTL5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9483:TMEM167A
gene id: 9483:TMEM167A
uniprot id: F7CZW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

9483:C9H12orf75
gene id: 9483:C9H12orf75
uniprot id: F7HDD5
names: Similarity
messages: Belongs to the OCC1 family.

9483:DRD1
gene id: 9483:DRD1
uniprot id: F7GPB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9483:LOC100386315
gene id: 9483:LOC100386315
uniprot id: F7I9W2
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9483:USP14
gene id: 9483:USP14
uniprot id: U3DHC9
uniprot id: U3DSU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9483:C7H1orf52
gene id: 9483:C7H1orf52
uniprot id: U3D9T0
names: Similarity
messages: Belongs to the UPF0690 family.

9483:RPL18A
gene id: 9483:RPL18A
uniprot id: A0A5F4WIS8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9483:TLCD1
gene id: 9483:TLCD1
uniprot id: F7EJ17
names: Subcellular Location Annotation
messages: Membrane

9483:DDAH2
gene id: 9483:DDAH2
uniprot id: U3E282
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9483:EDA2R
gene id: 9483:EDA2R
uniprot id: A0A8J8YCF7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PNPLA4
gene id: 9483:PNPLA4
uniprot id: A0A8I3X3T3
uniprot id: F7FNR1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:EIF3J
gene id: 9483:EIF3J
uniprot id: F7A6T5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9483:RPS6KB1
gene id: 9483:RPS6KB1
uniprot id: F7GCV0
uniprot id: F7IIP5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9483:CLP1
gene id: 9483:CLP1
uniprot id: U3BTP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9483:LOC100388510
gene id: 9483:LOC100388510
uniprot id: A0A7G3HQ39
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9483:TM4SF4
gene id: 9483:TM4SF4
uniprot id: A0A8I4A5Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9483:ATIC
gene id: 9483:ATIC
uniprot id: U3CG69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

9483:TBX18
gene id: 9483:TBX18
uniprot id: A0A2R8MFR8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:GFM2
gene id: 9483:GFM2
uniprot id: U3D1H4
uniprot id: U3F9Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9483:UBE2D4
gene id: 9483:UBE2D4
uniprot id: U3E9V5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:TBCB
gene id: 9483:TBCB
uniprot id: F7IEI4
names: Similarity
messages: Belongs to the TBCB family.

9483:MYOZ2
gene id: 9483:MYOZ2
uniprot id: F7IED9
names: Similarity
messages: Belongs to the myozenin family.

9483:MFSD11
gene id: 9483:MFSD11
uniprot id: F6PYN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9483:CCNA2
gene id: 9483:CCNA2
uniprot id: F7ILU7
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9483:SEC63
gene id: 9483:SEC63
uniprot id: A0A8I3WE90
uniprot id: B0KWH2
names: Subcellular Location Annotation
messages: Membrane

9483:SLC6A7
gene id: 9483:SLC6A7
uniprot id: F7GHJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9483:CPEB4
gene id: 9483:CPEB4
uniprot id: F7E421
uniprot id: F7E446
uniprot id: F7E4E6
names: Similarity
messages: Belongs to the RRM CPEB family.

9483:SBDS
gene id: 9483:SBDS
uniprot id: F6QRM2
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9483:TLCD4
gene id: 9483:TLCD4
uniprot id: U3CVH9
names: Subcellular Location Annotation
messages: Membrane

9483:MYO5C
gene id: 9483:MYO5C
uniprot id: U3BDP9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:TNFAIP8L2
gene id: 9483:TNFAIP8L2
uniprot id: B0KWC3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (By similarity). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (By similarity). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity).
messages: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
messages: Cytoplasm
messages: Lysosome
messages: May interact with CASP8; however, such result is unclear since could not reproduce the interaction with CASP8. Interacts with RAC1.
messages: Nucleus
messages: Phosphorylated by TAK1/MAP3K7; this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation.
messages: The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding (By similarity).
messages: Ubiquitinated in a BTRC-depdent manner; leading to degradation mediated through the proteasome pathway.

9483:CCR7
gene id: 9483:CCR7
uniprot id: A0A8I3W856
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:TAS2R41
gene id: 9483:TAS2R41
uniprot id: F7I726
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9483:MKX
gene id: 9483:MKX
uniprot id: F7FZ99
names: Subcellular Location Annotation
messages: Nucleus

9483:PRKAB2
gene id: 9483:PRKAB2
uniprot id: F6YM87
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9483:SCARA5
gene id: 9483:SCARA5
uniprot id: F6UGK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9483:VPS33B
gene id: 9483:VPS33B
uniprot id: F7IRH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9483:MMP26
gene id: 9483:MMP26
uniprot id: F6W5T8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9483:SNRPC
gene id: 9483:SNRPC
uniprot id: U3BKR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

9483:ALDH18A1
gene id: 9483:ALDH18A1
uniprot id: F7HR79
uniprot id: U3B9D8
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9483:SLC7A3
gene id: 9483:SLC7A3
uniprot id: F6S3I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9483:BCAS2
gene id: 9483:BCAS2
uniprot id: F7HWK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

9483:TCP1
gene id: 9483:TCP1
uniprot id: U3CAP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: centrosome

9483:CD93
gene id: 9483:CD93
uniprot id: A0A8I3WL84
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:RORA
gene id: 9483:RORA
uniprot id: U3FGL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9483:CDK5R1
gene id: 9483:CDK5R1
uniprot id: F7DFC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

9483:DNAJA1
gene id: 9483:DNAJA1
uniprot id: F7I6Q8
names: Subcellular Location Annotation
messages: Membrane

9483:BTF3L4
gene id: 9483:BTF3L4
uniprot id: F7I0E1
names: Similarity
messages: Belongs to the NAC-beta family.

9483:TNFSF4
gene id: 9483:TNFSF4
uniprot id: F7IAD3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:MED10
gene id: 9483:MED10
uniprot id: F7DB49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:S100A4
gene id: 9483:S100A4
uniprot id: U3F5Z7
names: Similarity
messages: Belongs to the S-100 family.

9483:TOMM22
gene id: 9483:TOMM22
uniprot id: F6TSD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9483:PLP1
gene id: 9483:PLP1
uniprot id: F7F5H2
uniprot id: U3BKX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9483:DSE
gene id: 9483:DSE
uniprot id: A0A8I3X984
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9483:PENK
gene id: 9483:PENK
uniprot id: F6WU13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9483:SNX21
gene id: 9483:SNX21
uniprot id: F7HVT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Membrane

9483:ODF1
gene id: 9483:ODF1
uniprot id: A0A8I3W4R6
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9483:LOC100398983
gene id: 9483:LOC100398983
uniprot id: U3EG95
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

9483:VPS18
gene id: 9483:VPS18
uniprot id: F7IT14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9483:SEMA3D
gene id: 9483:SEMA3D
uniprot id: F7D0I7
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TGFB1
gene id: 9483:TGFB1
uniprot id: U3D3J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

9483:MPP3
gene id: 9483:MPP3
uniprot id: F6SGV1
names: Similarity
messages: Belongs to the MAGUK family.

9483:RAB3A
gene id: 9483:RAB3A
uniprot id: F6WFR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9483:SCN2A
gene id: 9483:SCN2A
uniprot id: U3FV47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9483:RTF2
gene id: 9483:RTF2
uniprot id: F7I571
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9483:RNFT2
gene id: 9483:RNFT2
uniprot id: A0A8I3WH16
uniprot id: F7IRH7
names: Subcellular Location Annotation
messages: Membrane

9483:SUSD5
gene id: 9483:SUSD5
uniprot id: A0A2R8P1M3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CAND1
gene id: 9483:CAND1
uniprot id: F6XT20
names: Similarity
messages: Belongs to the CAND family.

9483:PDGFRA
gene id: 9483:PDGFRA
uniprot id: F6VUA7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9483:GTF2H4
gene id: 9483:GTF2H4
uniprot id: A0A8J8XII6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9483:DLK2
gene id: 9483:DLK2
uniprot id: F7BVC0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SLC25A40
gene id: 9483:SLC25A40
uniprot id: U3F7R9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9483:DLL4
gene id: 9483:DLL4
uniprot id: A0A2R8PCZ4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9483:DNM2
gene id: 9483:DNM2
uniprot id: F7GCH1
uniprot id: U3EAV4
uniprot id: U3ELC4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9483:HS6ST2
gene id: 9483:HS6ST2
uniprot id: F6S5X6
uniprot id: U3CB80
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:JUN
gene id: 9483:JUN
uniprot id: U3ED65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9483:LOC100395853
gene id: 9483:LOC100395853
uniprot id: A0A8I3X4M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9483:MTHFD2L
gene id: 9483:MTHFD2L
uniprot id: F6ZFR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities.
messages: Mitochondrion inner membrane

9483:PIK3R1
gene id: 9483:PIK3R1
uniprot id: F7IP48
uniprot id: F7IP49
uniprot id: U3ERL3
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9483:SERPINI1
gene id: 9483:SERPINI1
uniprot id: U3EYE3
names: Similarity
messages: Belongs to the serpin family.

9483:TOB2
gene id: 9483:TOB2
uniprot id: F7HNT3
names: Similarity
messages: Belongs to the BTG family.

9483:TSPAN2
gene id: 9483:TSPAN2
uniprot id: A0A2R8MT59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:TRIM33
gene id: 9483:TRIM33
uniprot id: F7I5Z0
uniprot id: F7I621
names: Subcellular Location Annotation
messages: Cytoplasm

9483:SNX4
gene id: 9483:SNX4
uniprot id: U3DS06
names: Similarity
messages: Belongs to the sorting nexin family.

9483:SLC7A10
gene id: 9483:SLC7A10
uniprot id: F6W3J6
names: Subcellular Location Annotation
messages: Membrane

9483:P2RY2
gene id: 9483:P2RY2
uniprot id: F7IT87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PGLYRP2
gene id: 9483:PGLYRP2
uniprot id: F6XHP9
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9483:IMMP2L
gene id: 9483:IMMP2L
uniprot id: U3AWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

9483:FUBP1
gene id: 9483:FUBP1
uniprot id: A0A8I3WEM8
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100400489
gene id: 9483:LOC100400489
uniprot id: A0A5F4W184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:NCBP2
gene id: 9483:NCBP2
uniprot id: F7B893
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9483:PARN
gene id: 9483:PARN
uniprot id: U3D8R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm

9483:IDH3A
gene id: 9483:IDH3A
uniprot id: U3E4Q8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9483:CCNT1
gene id: 9483:CCNT1
uniprot id: F7I6V2
names: Similarity
messages: Belongs to the cyclin family.

9483:VAMP8
gene id: 9483:VAMP8
uniprot id: A0A8I3VZ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9483:MRPS14
gene id: 9483:MRPS14
uniprot id: U3DJ52
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9483:S100A6
gene id: 9483:S100A6
uniprot id: F6W664
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
messages: Nucleus envelope

9483:MGP
gene id: 9483:MGP
uniprot id: F7INT5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9483:FGF23
gene id: 9483:FGF23
uniprot id: A0A8I3WME0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:EZH2
gene id: 9483:EZH2
uniprot id: A0A5K1USM6
uniprot id: U3DM49
names: Subcellular Location Annotation
messages: Nucleus

9483:NLGN1
gene id: 9483:NLGN1
uniprot id: U3FSR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9483:EPHA3
gene id: 9483:EPHA3
uniprot id: U3DED6
names: Subcellular Location Annotation
messages: Membrane

9483:RFC4
gene id: 9483:RFC4
uniprot id: U3CKN0
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9483:ASF1A
gene id: 9483:ASF1A
uniprot id: F6QXV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9483:LOC100395849
gene id: 9483:LOC100395849
uniprot id: B0VXL1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:KIF16B
gene id: 9483:KIF16B
uniprot id: A0A2R8NDI8
uniprot id: F7HM80
uniprot id: U3E809
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:RPL13A
gene id: 9483:RPL13A
uniprot id: F7EY23
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9483:EVA1C
gene id: 9483:EVA1C
uniprot id: B0VXF8
uniprot id: U3DF70
names: Similarity
messages: Belongs to the EVA1 family.

9483:PRDX2
gene id: 9483:PRDX2
uniprot id: U3BQQ2
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9483:UBL4A
gene id: 9483:UBL4A
uniprot id: B0KWT6
uniprot id: U3DZM8
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
messages: Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with BAG6; the interaction is direct and required for UBL4A protein stability. Interacts with USP13; may be indirect via BAG6.
messages: Nucleus
messages: Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT complex and SGTA and therefore may regulate client proteins fate.
messages: cytosol

9483:TMED9
gene id: 9483:TMED9
uniprot id: A0A2R8M2U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:PLPP3
gene id: 9483:PLPP3
uniprot id: U3D0U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9483:WTAP
gene id: 9483:WTAP
uniprot id: U3E922
names: Similarity
messages: Belongs to the fl(2)d family.

9483:DHDDS
gene id: 9483:DHDDS
uniprot id: A0A8I3W458
uniprot id: U3CUJ0
names: Similarity
messages: Belongs to the UPP synthase family.

9483:PTGES
gene id: 9483:PTGES
uniprot id: F7BE45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9483:OLFML2A
gene id: 9483:OLFML2A
uniprot id: F7H8G8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PTCD2
gene id: 9483:PTCD2
uniprot id: F6WCE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

9483:MMP15
gene id: 9483:MMP15
uniprot id: U3CVZ5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9483:DAZAP2
gene id: 9483:DAZAP2
uniprot id: F7FWV5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9483:HAUS1
gene id: 9483:HAUS1
uniprot id: U3FPB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9483:CCDC126
gene id: 9483:CCDC126
uniprot id: F7HKB9
names: Subcellular Location Annotation
messages: Secreted

9483:NMBR
gene id: 9483:NMBR
uniprot id: F7I8P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:KHDRBS2
gene id: 9483:KHDRBS2
uniprot id: F7CWI3
names: Similarity
messages: Belongs to the KHDRBS family.

9483:CNN3
gene id: 9483:CNN3
uniprot id: F7IS17
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9483:PSMB9
gene id: 9483:PSMB9
uniprot id: F7I2S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9483:LOC100894903
gene id: 9483:LOC100894903
uniprot id: A0A8I3WMT9
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9483:AARS1
gene id: 9483:AARS1
uniprot id: U3C7R0
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9483:FAM162B
gene id: 9483:FAM162B
uniprot id: A0A5F4VWJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9483:GABRA2
gene id: 9483:GABRA2
uniprot id: U3DZK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9483:CPSF3
gene id: 9483:CPSF3
uniprot id: F7HIE0
names: Subcellular Location Annotation
messages: Nucleus

9483:TMEM50B
gene id: 9483:TMEM50B
uniprot id: B0VXG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9483:TXNL4B
gene id: 9483:TXNL4B
uniprot id: F7GNU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9483:ASIC3
gene id: 9483:ASIC3
uniprot id: F6ZWY7
names: Subcellular Location Annotation
messages: Membrane

9483:PLXNC1
gene id: 9483:PLXNC1
uniprot id: U3CZ51
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:GRHPR
gene id: 9483:GRHPR
uniprot id: U3D1B0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9483:MAU2
gene id: 9483:MAU2
uniprot id: U3DDI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9483:WDR82
gene id: 9483:WDR82
uniprot id: F7IDG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9483:ATP6V1A
gene id: 9483:ATP6V1A
uniprot id: A0A8J8XGP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Vesicle
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

9483:MRPL36
gene id: 9483:MRPL36
uniprot id: A0A2R8NA09
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9483:SLC39A9
gene id: 9483:SLC39A9
uniprot id: U3DR82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

9483:MAPKAP1
gene id: 9483:MAPKAP1
uniprot id: F7B3S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIN1 family.
messages: Cytoplasmic vesicle

9483:RAB27A
gene id: 9483:RAB27A
uniprot id: F7C0F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9483:PADI1
gene id: 9483:PADI1
uniprot id: F7IT96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9483:CAPZA2
gene id: 9483:CAPZA2
uniprot id: Q2QLG4
uniprot id: U3DUR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity).

9483:GGPS1
gene id: 9483:GGPS1
uniprot id: F7EFP1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9483:LOC100395443
gene id: 9483:LOC100395443
uniprot id: U3EBQ5
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9483:MRGPRX1
gene id: 9483:MRGPRX1
uniprot id: F7H5A0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:NUDC
gene id: 9483:NUDC
uniprot id: U3FM55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9483:DNAL4
gene id: 9483:DNAL4
uniprot id: F6Q578
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9483:HSPB2
gene id: 9483:HSPB2
uniprot id: F6ZR37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9483:CAMK1G
gene id: 9483:CAMK1G
uniprot id: F7G5K6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:MRPS5
gene id: 9483:MRPS5
uniprot id: A0A5F4W268
uniprot id: F7HP99
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9483:CDH9
gene id: 9483:CDH9
uniprot id: U3ECE5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:LOC100410110
gene id: 9483:LOC100410110
uniprot id: F7HAB8
names: Similarity
messages: Belongs to the amidase family.

9483:POLG2
gene id: 9483:POLG2
uniprot id: F7F7L7
names: Subcellular Location Annotation
messages: Mitochondrion

9483:QNG1
gene id: 9483:QNG1
uniprot id: A0A8I3W0E7
uniprot id: F7EBM2
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

9483:FGF4
gene id: 9483:FGF4
uniprot id: F7I9F2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:PMP2
gene id: 9483:PMP2
uniprot id: F6S344
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9483:CHST12
gene id: 9483:CHST12
uniprot id: F7INE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:VSX1
gene id: 9483:VSX1
uniprot id: A0A8I3WX80
names: Subcellular Location Annotation
messages: Nucleus

9483:CFAP144
gene id: 9483:CFAP144
uniprot id: U3BKU9
names: Similarity
messages: Belongs to the CFAP144 family.

9483:ALX1
gene id: 9483:ALX1
uniprot id: A0A8I3WN66
names: Subcellular Location Annotation
messages: Nucleus

9483:NSA2
gene id: 9483:NSA2
uniprot id: F7HWF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9483:UBA5
gene id: 9483:UBA5
uniprot id: U3DWH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9483:VPS45
gene id: 9483:VPS45
uniprot id: U3EPE1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9483:PPM1D
gene id: 9483:PPM1D
uniprot id: F7IIZ4
names: Similarity
messages: Belongs to the PP2C family.

9483:KDR
gene id: 9483:KDR
uniprot id: A0A8J8YCV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9483:SLC50A1
gene id: 9483:SLC50A1
uniprot id: U3CVH4
uniprot id: U3F7F8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9483:OLFR639
gene id: 9483:OLFR639
uniprot id: B0VXC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:HBQ1
gene id: 9483:HBQ1
uniprot id: B0VX79
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.

9483:LOC100387829
gene id: 9483:LOC100387829
uniprot id: A0A2R8P7K0
names: Similarity
messages: Belongs to the MARCKS family.

9483:AMT
gene id: 9483:AMT
uniprot id: U3DTA9
uniprot id: U3F3F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9483:LHPP
gene id: 9483:LHPP
uniprot id: U3D175
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9483:PTGR1
gene id: 9483:PTGR1
uniprot id: F7FJC4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9483:WIF1
gene id: 9483:WIF1
uniprot id: U3D640
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:PAM16
gene id: 9483:PAM16
uniprot id: U3BYV6
names: Similarity
messages: Belongs to the TIM16/PAM16 family.

9483:CCNC
gene id: 9483:CCNC
uniprot id: F7ING0
names: Similarity
messages: Belongs to the cyclin family.

9483:S100A11
gene id: 9483:S100A11
uniprot id: F7DD73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

9483:VPS35L
gene id: 9483:VPS35L
uniprot id: F7IR81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS35L family.
messages: Endosome

9483:PPTC7
gene id: 9483:PPTC7
uniprot id: F7B3T3
names: Similarity
messages: Belongs to the PP2C family.

9483:TRNAU1AP
gene id: 9483:TRNAU1AP
uniprot id: F7HVM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9483:NGF
gene id: 9483:NGF
uniprot id: U3CKT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted

9483:NRN1L
gene id: 9483:NRN1L
uniprot id: F7I5C5
names: Similarity
messages: Belongs to the neuritin family.

9483:VSX2
gene id: 9483:VSX2
uniprot id: F7BVN5
names: Subcellular Location Annotation
messages: Nucleus

9483:PFAS
gene id: 9483:PFAS
uniprot id: F7HZR0
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

9483:MOB1B
gene id: 9483:MOB1B
uniprot id: F7I280
names: Similarity
messages: Belongs to the MOB1/phocein family.

9483:TIGD7
gene id: 9483:TIGD7
uniprot id: U3F721
names: Subcellular Location Annotation
messages: Nucleus

9483:PEX10
gene id: 9483:PEX10
uniprot id: U3FIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9483:YWHAE
gene id: 9483:YWHAE
uniprot id: A0A8I3W8K2
uniprot id: F7GZ27
names: Similarity
messages: Belongs to the 14-3-3 family.

9483:RPS6KA3
gene id: 9483:RPS6KA3
uniprot id: A0A5F4W771
uniprot id: A0A5F4WM03
uniprot id: F7GWP8
uniprot id: U3D5H3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9483:SCFD1
gene id: 9483:SCFD1
uniprot id: F7ISQ5
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9483:GEM
gene id: 9483:GEM
uniprot id: F7EIY8
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9483:HAPLN4
gene id: 9483:HAPLN4
uniprot id: A0A8I3VZB5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CCDC34
gene id: 9483:CCDC34
uniprot id: F7IKF2
names: Subcellular Location Annotation
messages: flagellum

9483:AFM
gene id: 9483:AFM
uniprot id: A0A5F4VV46
names: Subcellular Location Annotation
messages: Secreted

9483:GALNT7
gene id: 9483:GALNT7
uniprot id: F7D606
uniprot id: F7I1I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:TRIM23
gene id: 9483:TRIM23
uniprot id: U3BWI0
names: Subcellular Location Annotation
messages: Cytoplasm

9483:DCPS
gene id: 9483:DCPS
uniprot id: U3B9C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9483:TEX10
gene id: 9483:TEX10
uniprot id: U3C6J2
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9483:GNG3
gene id: 9483:GNG3
uniprot id: F7I3K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:VMA21
gene id: 9483:VMA21
uniprot id: F6S8Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9483:MBTPS1
gene id: 9483:MBTPS1
uniprot id: U3DTU4
names: Similarity
messages: Belongs to the peptidase S8 family.

9483:GABRG3
gene id: 9483:GABRG3
uniprot id: U3DY73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:LOC100396218
gene id: 9483:LOC100396218
uniprot id: F7IPB7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9483:CSTF2
gene id: 9483:CSTF2
uniprot id: F7HWT7
uniprot id: F7HWU0
names: Subcellular Location Annotation
messages: Nucleus

9483:YTHDF3
gene id: 9483:YTHDF3
uniprot id: U3CP42
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9483:HMGN3
gene id: 9483:HMGN3
uniprot id: U3C9L4
uniprot id: U3FJW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9483:DUSP6
gene id: 9483:DUSP6
uniprot id: A0A2R8MQX9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9483:HTT
gene id: 9483:HTT
uniprot id: B7XBM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

9483:HBE1
gene id: 9483:HBE1
uniprot id: B0VXB7
uniprot id: P68026
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.
messages: Red blood cells.
messages: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

9483:CNIH1
gene id: 9483:CNIH1
uniprot id: F7CT80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9483:RFNG
gene id: 9483:RFNG
uniprot id: F6SII8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:RPL39L
gene id: 9483:RPL39L
uniprot id: A0A8I3W7A5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9483:STMN1
gene id: 9483:STMN1
uniprot id: U3DF36
names: Similarity
messages: Belongs to the stathmin family.

9483:CXXC1
gene id: 9483:CXXC1
uniprot id: U3DLM1
names: Subcellular Location Annotation
messages: Nucleus

9483:CHMP4C
gene id: 9483:CHMP4C
uniprot id: F6SNN9
uniprot id: U3FI70
names: Similarity
messages: Belongs to the SNF7 family.

9483:GTF2H1
gene id: 9483:GTF2H1
uniprot id: A0A8I3W2V2
uniprot id: U3DYN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9483:ARV1
gene id: 9483:ARV1
uniprot id: A0A2R8NEP4
uniprot id: F6VUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9483:PRPSAP2
gene id: 9483:PRPSAP2
uniprot id: U3EA77
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9483:DUSP26
gene id: 9483:DUSP26
uniprot id: F7HXW2
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9483:LOC100394558
gene id: 9483:LOC100394558
uniprot id: B0KW94
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated at Tyr-155 by PARP1 in presence of HPF1.
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May play a role during erythropoiesis (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: nucleolus

9483:AGRP
gene id: 9483:AGRP
uniprot id: F7I534
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:CYP11B2
gene id: 9483:CYP11B2
uniprot id: A0A8I3WBU5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:DNAJC16
gene id: 9483:DNAJC16
uniprot id: F6XIZ7
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

9483:EFHC1
gene id: 9483:EFHC1
uniprot id: A0A2R8PDG3
names: Subcellular Location Annotation
messages: cilium axoneme

9483:VAMP3
gene id: 9483:VAMP3
uniprot id: U3F6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9483:BANP
gene id: 9483:BANP
uniprot id: A0A2R8MB62
uniprot id: F7E7Q1
uniprot id: U3D2P4
uniprot id: U3FSZ4
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9483:SERINC5
gene id: 9483:SERINC5
uniprot id: A0A2R8M3X6
uniprot id: U3E2A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9483:CASP14
gene id: 9483:CASP14
uniprot id: F7HWS2
names: Similarity
messages: Belongs to the peptidase C14A family.

9483:MPDU1
gene id: 9483:MPDU1
uniprot id: F7GNS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9483:ECSIT
gene id: 9483:ECSIT
uniprot id: U3C180
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

9483:DPPA2
gene id: 9483:DPPA2
uniprot id: F6YXD7
names: Subcellular Location Annotation
messages: Nucleus

9483:NECAP1
gene id: 9483:NECAP1
uniprot id: U3CAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9483:CFAP107
gene id: 9483:CFAP107
uniprot id: F6WMT0
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9483:PDIA6
gene id: 9483:PDIA6
uniprot id: U3ERB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

9483:RPL10A
gene id: 9483:RPL10A
uniprot id: F6XC43
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9483:ITGB5
gene id: 9483:ITGB5
uniprot id: U3FGD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9483:PAPOLA
gene id: 9483:PAPOLA
uniprot id: F7HE64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

9483:RPLP2
gene id: 9483:RPLP2
uniprot id: F6U184
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9483:SEMA6C
gene id: 9483:SEMA6C
uniprot id: U3E605
uniprot id: U3EH97
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:RHBDL1
gene id: 9483:RHBDL1
uniprot id: F6YAM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9483:INKA2
gene id: 9483:INKA2
uniprot id: F6U9M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9483:TPMT
gene id: 9483:TPMT
uniprot id: F6PNF2
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Monomer.

9483:SERPINC1
gene id: 9483:SERPINC1
uniprot id: F6XBM4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9483:JPH2
gene id: 9483:JPH2
uniprot id: F7EC17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9483:AK5
gene id: 9483:AK5
uniprot id: U3F4C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9483:UFC1
gene id: 9483:UFC1
uniprot id: U3BVZ1
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9483:SGCZ
gene id: 9483:SGCZ
uniprot id: F7BV23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9483:YKT6
gene id: 9483:YKT6
uniprot id: F7HXA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9483:ALKBH1
gene id: 9483:ALKBH1
uniprot id: F7IM93
names: Cofactor
names: Similarity
messages: Belongs to the alkB family.
messages: Binds 1 Fe(2+) ion per subunit.

9483:ELK4
gene id: 9483:ELK4
uniprot id: U3FE22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:HTR2C
gene id: 9483:HTR2C
uniprot id: F6S1A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TRAF2
gene id: 9483:TRAF2
uniprot id: U3B0E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9483:C11H11orf54
gene id: 9483:C11H11orf54
uniprot id: A0A8I4A4N5
uniprot id: F6RKF2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9483:IFI6
gene id: 9483:IFI6
uniprot id: F7IKE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9483:RPS21
gene id: 9483:RPS21
uniprot id: F7IE69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9483:SYT14
gene id: 9483:SYT14
uniprot id: F7GXT6
names: Similarity
messages: Belongs to the synaptotagmin family.

9483:FUCA1
gene id: 9483:FUCA1
uniprot id: F7HZM3
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9483:KCNG1
gene id: 9483:KCNG1
uniprot id: F6RE04
names: Subcellular Location Annotation
messages: Membrane

9483:RRP1B
gene id: 9483:RRP1B
uniprot id: F7IF19
names: Similarity
messages: Belongs to the RRP1 family.

9483:LOC100397855
gene id: 9483:LOC100397855
uniprot id: F7H563
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ZNF687
gene id: 9483:ZNF687
uniprot id: B0KWC0
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9483:TMEM186
gene id: 9483:TMEM186
uniprot id: F7IJG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9483:IFITM5
gene id: 9483:IFITM5
uniprot id: A0A2R8MEJ4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9483:CTSL
gene id: 9483:CTSL
uniprot id: A0A8J8YMX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9483:DHFR
gene id: 9483:DHFR
uniprot id: F7IFS4
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9483:KCNH7
gene id: 9483:KCNH7
uniprot id: A0A2R8MVL6
names: Subcellular Location Annotation
messages: Membrane

9483:TYR
gene id: 9483:TYR
uniprot id: F7GAX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9483:GOLPH3
gene id: 9483:GOLPH3
uniprot id: F7I3I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9483:MRPL50
gene id: 9483:MRPL50
uniprot id: F7I2I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9483:RIC3
gene id: 9483:RIC3
uniprot id: F6TPK5
uniprot id: U3CIL7
names: Similarity
messages: Belongs to the ric-3 family.

9483:YEATS4
gene id: 9483:YEATS4
uniprot id: F7HFQ0
names: Subcellular Location Annotation
messages: Nucleus

9483:EPDR1
gene id: 9483:EPDR1
uniprot id: U3DYH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ependymin family.
messages: Binds anionic lipids and gangliosides at acidic pH.
messages: Lysosome lumen
messages: Secreted

9483:SRD5A1
gene id: 9483:SRD5A1
uniprot id: A0A5F4WHZ2
uniprot id: F6XII1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9483:LDB1
gene id: 9483:LDB1
uniprot id: F7ECI5
uniprot id: U3FLV7
names: Similarity
messages: Belongs to the LDB family.

9483:HOXD1
gene id: 9483:HOXD1
uniprot id: F7EML3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9483:RPS8
gene id: 9483:RPS8
uniprot id: F6PPW3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

9483:DRAM2
gene id: 9483:DRAM2
uniprot id: F7GN83
names: Subcellular Location Annotation
messages: Membrane

9483:NANOS2
gene id: 9483:NANOS2
uniprot id: A0A2R8M6M2
names: Similarity
messages: Belongs to the nanos family.

9483:TSEN34
gene id: 9483:TSEN34
uniprot id: B0VXI7
uniprot id: U3EXA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9483:LOC100387227
gene id: 9483:LOC100387227
uniprot id: A0A509EP45
names: Similarity
messages: Belongs to the MHC class II family.

9483:ZKSCAN5
gene id: 9483:ZKSCAN5
uniprot id: F7IPF4
names: Subcellular Location Annotation
messages: Nucleus

9483:OLFR599
gene id: 9483:OLFR599
uniprot id: B0VXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:IWS1
gene id: 9483:IWS1
uniprot id: F7EW11
uniprot id: U3DIT9
names: Subcellular Location Annotation
messages: Nucleus

9483:IPO4
gene id: 9483:IPO4
uniprot id: U3ESP2
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ABCF2
gene id: 9483:ABCF2
uniprot id: F6YVA2
names: Subunit
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

9483:AUP1
gene id: 9483:AUP1
uniprot id: F7D4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AUP1 family.
messages: Membrane

9483:PCSK7
gene id: 9483:PCSK7
uniprot id: F7ISH0
names: Similarity
messages: Belongs to the peptidase S8 family.

9483:SCUBE2
gene id: 9483:SCUBE2
uniprot id: A0A2R8N1C5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:SSH3
gene id: 9483:SSH3
uniprot id: F7CT12
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9483:CCNO
gene id: 9483:CCNO
uniprot id: F7GQ68
names: Similarity
messages: Belongs to the cyclin family.

9483:CCL3L3
gene id: 9483:CCL3L3
uniprot id: F7HEP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:DGAT1
gene id: 9483:DGAT1
uniprot id: A0A5F4W2M8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9483:ADRB1
gene id: 9483:ADRB1
uniprot id: F7GC16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:DES
gene id: 9483:DES
uniprot id: B0KWJ0
names: Similarity
messages: Belongs to the intermediate filament family.

9483:SRP19
gene id: 9483:SRP19
uniprot id: F6V6L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9483:SLC33A1
gene id: 9483:SLC33A1
uniprot id: F6ZYC7
names: Subcellular Location Annotation
messages: Membrane

9483:ARMCX2
gene id: 9483:ARMCX2
uniprot id: F7GD48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9483:ATP8B2
gene id: 9483:ATP8B2
uniprot id: A0A2R8P539
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:PPFIA3
gene id: 9483:PPFIA3
uniprot id: F7D8Z7
uniprot id: F7D921
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9483:BNIP3L
gene id: 9483:BNIP3L
uniprot id: A0A8I3W950
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9483:UFL1
gene id: 9483:UFL1
uniprot id: F7ILA7
names: Similarity
messages: Belongs to the UFL1 family.

9483:SLC30A3
gene id: 9483:SLC30A3
uniprot id: F6XQY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9483:NTF3
gene id: 9483:NTF3
uniprot id: A0A2R8PFD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9483:MMRN1
gene id: 9483:MMRN1
uniprot id: F7GB72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LXN
gene id: 9483:LXN
uniprot id: F6QAW6
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9483:ORC6
gene id: 9483:ORC6
uniprot id: A0A2R8MFH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9483:SNTG1
gene id: 9483:SNTG1
uniprot id: U3D7X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9483:HYAL2
gene id: 9483:HYAL2
uniprot id: F7HIH6
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9483:LYN
gene id: 9483:LYN
uniprot id: U3D0I6
uniprot id: U3DUJ3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:ATP5PD
gene id: 9483:ATP5PD
uniprot id: U3ECF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9483:A1CF
gene id: 9483:A1CF
uniprot id: F7I3P8
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ARL6
gene id: 9483:ARL6
uniprot id: U3EQH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9483:PLPPR1
gene id: 9483:PLPPR1
uniprot id: F7I2M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9483:LAMTOR3
gene id: 9483:LAMTOR3
uniprot id: F6WBU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9483:TRPM3
gene id: 9483:TRPM3
uniprot id: F7IBI8
uniprot id: F7IDP9
uniprot id: U3CRR3
names: Subcellular Location Annotation
messages: Membrane

9483:PTPRG
gene id: 9483:PTPRG
uniprot id: U3EX09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9483:CDKN3
gene id: 9483:CDKN3
uniprot id: F6X5L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9483:NETO2
gene id: 9483:NETO2
uniprot id: U3F8R6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SMPD2
gene id: 9483:SMPD2
uniprot id: F7I8K1
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9483:MRPL13
gene id: 9483:MRPL13
uniprot id: F7GRV5
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9483:TSPAN33
gene id: 9483:TSPAN33
uniprot id: U3DV06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:GATM
gene id: 9483:GATM
uniprot id: U3CX04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain.

9483:CNPY2
gene id: 9483:CNPY2
uniprot id: F7H125
names: Similarity
messages: Belongs to the canopy family.

9483:SPTLC2
gene id: 9483:SPTLC2
uniprot id: F7IPL5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9483:LACTB2
gene id: 9483:LACTB2
uniprot id: F7I4J0
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9483:WNT7A
gene id: 9483:WNT7A
uniprot id: Q1KYK6
uniprot id: U3CFU1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Wnt family.
messages: Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD5. Interacts with PORCN (By similarity). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (By similarity).
messages: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity).
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells.
messages: extracellular matrix

9483:FAM76B
gene id: 9483:FAM76B
uniprot id: F6Y823
names: Similarity
messages: Belongs to the FAM76 family.

9483:ZDHHC13
gene id: 9483:ZDHHC13
uniprot id: U3DKA5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:CTSV
gene id: 9483:CTSV
uniprot id: A0A2R8M4M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9483:LTBP1
gene id: 9483:LTBP1
uniprot id: U3C3V5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:ATP5MG
gene id: 9483:ATP5MG
uniprot id: F7GSV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9483:PGP
gene id: 9483:PGP
uniprot id: F7GP32
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

9483:DDB2
gene id: 9483:DDB2
uniprot id: F6XWE0
uniprot id: F6XWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

9483:DUSP10
gene id: 9483:DUSP10
uniprot id: F7HX42
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9483:AVP
gene id: 9483:AVP
uniprot id: A0A8I3WIQ5
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9483:DHPS
gene id: 9483:DHPS
uniprot id: F7FZK0
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

9483:ABCG2
gene id: 9483:ABCG2
uniprot id: U3EDG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9483:DEGS2
gene id: 9483:DEGS2
uniprot id: U3CEP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:KATNAL1
gene id: 9483:KATNAL1
uniprot id: U3BZV3
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9483:MAL2
gene id: 9483:MAL2
uniprot id: A0A2R8MA05
names: Subcellular Location Annotation
messages: Membrane

9483:LBX1
gene id: 9483:LBX1
uniprot id: F7FXK8
names: Subcellular Location Annotation
messages: Nucleus

9483:TBX19
gene id: 9483:TBX19
uniprot id: F6VM56
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:MAGI3
gene id: 9483:MAGI3
uniprot id: F7AVA2
uniprot id: U3FRJ0
names: Subcellular Location Annotation
messages: Membrane

9483:SEC61G
gene id: 9483:SEC61G
uniprot id: A0A5F4WGJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:ITGB3BP
gene id: 9483:ITGB3BP
uniprot id: U3BB95
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription coregulator that can have both coactivator and corepressor functions.
messages: centromere
messages: kinetochore

9483:SMPD1
gene id: 9483:SMPD1
uniprot id: F7IQZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

9483:NANOG
gene id: 9483:NANOG
uniprot id: F7I8S8
names: Subcellular Location Annotation
messages: Nucleus

9483:FAM133B
gene id: 9483:FAM133B
uniprot id: U3DPH9
names: Similarity
messages: Belongs to the FAM133 family.

9483:LHX3
gene id: 9483:LHX3
uniprot id: A0A2R8MDX0
uniprot id: F6XKK4
names: Subcellular Location Annotation
messages: Nucleus

9483:FOXL3
gene id: 9483:FOXL3
uniprot id: A0A2R8M6B4
names: Subcellular Location Annotation
messages: Nucleus

9483:MAP6
gene id: 9483:MAP6
uniprot id: F6UHV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

9483:KNG1
gene id: 9483:KNG1
uniprot id: A0A8I4A4X8
names: Subcellular Location Annotation
messages: extracellular space

9483:DUSP2
gene id: 9483:DUSP2
uniprot id: U3EPC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9483:MELK
gene id: 9483:MELK
uniprot id: F6SKD5
uniprot id: F7HM37
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9483:AASS
gene id: 9483:AASS
uniprot id: F7I9Y6
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9483:DHRS7C
gene id: 9483:DHRS7C
uniprot id: F7II92
uniprot id: U3FD97
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:HADHA
gene id: 9483:HADHA
uniprot id: F7HUX7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9483:VEZT
gene id: 9483:VEZT
uniprot id: U3BY21
uniprot id: U3DX34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9483:TMEM198
gene id: 9483:TMEM198
uniprot id: B0KWJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9483:CRYZ
gene id: 9483:CRYZ
uniprot id: F7GNH5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9483:TRIQK
gene id: 9483:TRIQK
uniprot id: F7GTE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:S100A8
gene id: 9483:S100A8
uniprot id: A0A8J8YBA8
names: Similarity
messages: Belongs to the S-100 family.

9483:RNASEH1
gene id: 9483:RNASEH1
uniprot id: F7H3J8
uniprot id: U3CQT2
uniprot id: U3FRY9
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9483:FOXJ3
gene id: 9483:FOXJ3
uniprot id: U3BLV8
names: Subcellular Location Annotation
messages: Nucleus

9483:POLR1D
gene id: 9483:POLR1D
uniprot id: F7DLJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

9483:CTSC
gene id: 9483:CTSC
uniprot id: U3CIA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9483:HPS6
gene id: 9483:HPS6
uniprot id: F7G6I5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9483:TGFBI
gene id: 9483:TGFBI
uniprot id: U3D692
names: Subcellular Location Annotation
messages: extracellular matrix

9483:PRC1
gene id: 9483:PRC1
uniprot id: F7IEP8
uniprot id: U3F2X1
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

9483:GLOD4
gene id: 9483:GLOD4
uniprot id: U3ATV7
names: Similarity
messages: Belongs to the glyoxalase I family.

9483:NONO
gene id: 9483:NONO
uniprot id: U3F519
names: Subcellular Location Annotation
messages: Nucleus speckle

9483:CCT6A
gene id: 9483:CCT6A
uniprot id: F7IN44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9483:BRINP2
gene id: 9483:BRINP2
uniprot id: F7E830
names: Similarity
messages: Belongs to the BRINP family.

9483:MRPS16
gene id: 9483:MRPS16
uniprot id: F7GYM4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9483:TMEM115
gene id: 9483:TMEM115
uniprot id: F7DM07
names: Subcellular Location Annotation
messages: Membrane

9483:AMER2
gene id: 9483:AMER2
uniprot id: F7H2Q2
names: Similarity
messages: Belongs to the Amer family.

9483:TACR2
gene id: 9483:TACR2
uniprot id: A0A2R8MLH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SVBP
gene id: 9483:SVBP
uniprot id: A0A8I3W3E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

9483:SLC44A3
gene id: 9483:SLC44A3
uniprot id: U3D2I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9483:TMOD3
gene id: 9483:TMOD3
uniprot id: F7BX02
names: Subcellular Location Annotation
messages: cytoskeleton

9483:SCUBE3
gene id: 9483:SCUBE3
uniprot id: A0A5F4WJ90
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:CBL
gene id: 9483:CBL
uniprot id: F7CSE3
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9483:DCLRE1A
gene id: 9483:DCLRE1A
uniprot id: U3DB16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9483:HOXC12
gene id: 9483:HOXC12
uniprot id: F7IAK9
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100401239
gene id: 9483:LOC100401239
uniprot id: A0A2R8MVQ0
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

9483:TMEM41B
gene id: 9483:TMEM41B
uniprot id: F6U6D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9483:PCNX4
gene id: 9483:PCNX4
uniprot id: F7HUM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9483:MFF
gene id: 9483:MFF
uniprot id: A0A8I3WRP1
uniprot id: A0A8I3X5X3
uniprot id: F7BAA2
uniprot id: F7I7Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.
messages: synaptic vesicle

9483:NSUN5
gene id: 9483:NSUN5
uniprot id: U3FK60
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9483:AMER3
gene id: 9483:AMER3
uniprot id: U3ERK3
names: Similarity
messages: Belongs to the Amer family.

9483:PAN3
gene id: 9483:PAN3
uniprot id: F7FBS4
uniprot id: U3BH95
uniprot id: U3F559
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

9483:LOC100402270
gene id: 9483:LOC100402270
uniprot id: F7HA83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ME3
gene id: 9483:ME3
uniprot id: A0A2R8MMW3
uniprot id: A0A2R8MQ64
uniprot id: A0A5F4WDJ1
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9483:SLC35F6
gene id: 9483:SLC35F6
uniprot id: U3DSE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9483:TNFSF8
gene id: 9483:TNFSF8
uniprot id: F7HVK4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:BEST1
gene id: 9483:BEST1
uniprot id: F7IFS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9483:P2RX3
gene id: 9483:P2RX3
uniprot id: F6VP75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9483:CDCA7
gene id: 9483:CDCA7
uniprot id: F7IND7
uniprot id: U3BCY5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:RTCB
gene id: 9483:RTCB
uniprot id: U3CZR4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9483:AASDH
gene id: 9483:AASDH
uniprot id: A0A8I3X0Z9
uniprot id: F6QFB5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:NDUFB7
gene id: 9483:NDUFB7
uniprot id: F7HN05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9483:AP2M1
gene id: 9483:AP2M1
uniprot id: F7F7R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9483:ATP6V1C1
gene id: 9483:ATP6V1C1
uniprot id: F7INY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9483:CDK2AP2
gene id: 9483:CDK2AP2
uniprot id: F6ZYF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9483:CRTC3
gene id: 9483:CRTC3
uniprot id: F7D1B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9483:YES1
gene id: 9483:YES1
uniprot id: U3DF65
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:PPM1L
gene id: 9483:PPM1L
uniprot id: U3BGK7
names: Similarity
messages: Belongs to the PP2C family.

9483:HNRNPDL
gene id: 9483:HNRNPDL
uniprot id: F6UJD1
uniprot id: U3CE03
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:IL19
gene id: 9483:IL19
uniprot id: A0A2R8MR56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9483:PPP1CB
gene id: 9483:PPP1CB
uniprot id: U3DD84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9483:ZNF287
gene id: 9483:ZNF287
uniprot id: A0A8I3WZE2
names: Subcellular Location Annotation
messages: Nucleus

9483:RAB39B
gene id: 9483:RAB39B
uniprot id: B0KWV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9483:SLC39A11
gene id: 9483:SLC39A11
uniprot id: A0A5K1V085
uniprot id: F6WNH0
names: Subcellular Location Annotation
messages: Membrane

9483:IL10
gene id: 9483:IL10
uniprot id: A0A7R8GUT3
uniprot id: Q0Z972
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-10 family.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Immune regulatory cytokine.
messages: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
messages: Secreted

9483:CACNG1
gene id: 9483:CACNG1
uniprot id: F6QLS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

9483:S100PBP
gene id: 9483:S100PBP
uniprot id: U3DXQ9
names: Subcellular Location Annotation
messages: Nucleus

9483:NIT2
gene id: 9483:NIT2
uniprot id: U3EDE1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9483:DACT1
gene id: 9483:DACT1
uniprot id: U3B9U5
uniprot id: U3BSZ1
names: Similarity
messages: Belongs to the dapper family.

9483:HSPB8
gene id: 9483:HSPB8
uniprot id: F7ALK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9483:SATB2
gene id: 9483:SATB2
uniprot id: U3CZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9483:IRF5
gene id: 9483:IRF5
uniprot id: F6RYK3
uniprot id: F6SJR4
names: Subcellular Location Annotation
messages: Nucleus

9483:PC
gene id: 9483:PC
uniprot id: U3D6Y3
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

9483:FBP1
gene id: 9483:FBP1
uniprot id: F7DT76
names: Similarity
messages: Belongs to the FBPase class 1 family.

9483:RGS5
gene id: 9483:RGS5
uniprot id: F6TDR7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9483:KIN
gene id: 9483:KIN
uniprot id: F7CBX1
uniprot id: U3CW28
names: Similarity
messages: Belongs to the KIN17 family.

9483:USP4
gene id: 9483:USP4
uniprot id: F6TSE3
uniprot id: F6TSU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9483:PUF60
gene id: 9483:PUF60
uniprot id: A0A8J8XV49
uniprot id: U3CWN2
uniprot id: U3DDS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

9483:LOC108587699
gene id: 9483:LOC108587699
uniprot id: B0VX89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TRIM56
gene id: 9483:TRIM56
uniprot id: F7I5G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9483:UBAC2
gene id: 9483:UBAC2
uniprot id: F7FK29
names: Subcellular Location Annotation
messages: Membrane

9483:TENT5A
gene id: 9483:TENT5A
uniprot id: A0A2R8MMQ7
names: Similarity
messages: Belongs to the TENT family.

9483:PIK3C2A
gene id: 9483:PIK3C2A
uniprot id: U3E5M4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9483:SNTB1
gene id: 9483:SNTB1
uniprot id: U3BJ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9483:LEPROTL1
gene id: 9483:LEPROTL1
uniprot id: U3FN14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9483:TMEM107
gene id: 9483:TMEM107
uniprot id: U3DQS6
names: Subcellular Location Annotation
messages: Membrane

9483:NGDN
gene id: 9483:NGDN
uniprot id: F7I2L1
names: Subcellular Location Annotation
messages: nucleolus

9483:DCN
gene id: 9483:DCN
uniprot id: F7HDP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

9483:LOC103790239
gene id: 9483:LOC103790239
uniprot id: A0A8I3WWI3
names: Similarity
messages: Belongs to the GAGE family.

9483:ATP5F1C
gene id: 9483:ATP5F1C
uniprot id: F7I4L8
uniprot id: F7I4N1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9483:LOC100411291
gene id: 9483:LOC100411291
uniprot id: A0A8I3WFP9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9483:COX6B2
gene id: 9483:COX6B2
uniprot id: A0A8I3WWF5
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9483:LOC100385614
gene id: 9483:LOC100385614
uniprot id: F7HKW4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9483:EHD1
gene id: 9483:EHD1
uniprot id: B0KWK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9483:FABP12
gene id: 9483:FABP12
uniprot id: F6SDK8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:CPSF6
gene id: 9483:CPSF6
uniprot id: F7GPL3
uniprot id: F7GUT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9483:MRPL41
gene id: 9483:MRPL41
uniprot id: U3CV55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9483:ANAPC5
gene id: 9483:ANAPC5
uniprot id: F7IQN6
uniprot id: U3FF52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9483:SLC2A4
gene id: 9483:SLC2A4
uniprot id: U3C130
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9483:INTS3
gene id: 9483:INTS3
uniprot id: F7FD65
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9483:SBF2
gene id: 9483:SBF2
uniprot id: A0A8I4A096
uniprot id: U3EI45
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9483:ACAP1
gene id: 9483:ACAP1
uniprot id: F6VZY8
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9483:MBOAT7
gene id: 9483:MBOAT7
uniprot id: F6XQJ1
names: Subcellular Location Annotation
messages: Membrane

9483:SHOX2
gene id: 9483:SHOX2
uniprot id: A0A8I3WT61
names: Subcellular Location Annotation
messages: Nucleus

9483:PPIL3
gene id: 9483:PPIL3
uniprot id: F7IMM5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:PEX19
gene id: 9483:PEX19
uniprot id: F7HYX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9483:GUF1
gene id: 9483:GUF1
uniprot id: F7IQ52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

9483:ST3GAL5
gene id: 9483:ST3GAL5
uniprot id: F7GY79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:RPS25
gene id: 9483:RPS25
uniprot id: F7AIV0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the small ribosomal subunit.

9483:EMC9
gene id: 9483:EMC9
uniprot id: F6ZHH5
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9483:E2F3
gene id: 9483:E2F3
uniprot id: F7HDR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9483:KRT20
gene id: 9483:KRT20
uniprot id: F7BJQ3
names: Similarity
messages: Belongs to the intermediate filament family.

9483:PMS1
gene id: 9483:PMS1
uniprot id: F7F052
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9483:MED30
gene id: 9483:MED30
uniprot id: U3E850
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9483:PROK2
gene id: 9483:PROK2
uniprot id: A0A2R8N9W0
uniprot id: A0A8I3WA50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9483:LOC100387174
gene id: 9483:LOC100387174
uniprot id: B0CMB1
names: Similarity
messages: Belongs to the serpin family.

9483:SLC13A5
gene id: 9483:SLC13A5
uniprot id: A0A8J8XV24
uniprot id: A0A8J8YKQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9483:LOC100411784
gene id: 9483:LOC100411784
uniprot id: A0A8I3X6E2
names: Similarity
messages: Belongs to the histone H2B family.

9483:RTCA
gene id: 9483:RTCA
uniprot id: A0A8I3X949
uniprot id: F7H6I6
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

9483:EPN2
gene id: 9483:EPN2
uniprot id: U3FWH5
names: Similarity
messages: Belongs to the epsin family.

9483:CHSY1
gene id: 9483:CHSY1
uniprot id: F7HY89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9483:CYB5R3
gene id: 9483:CYB5R3
uniprot id: U3C856
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9483:CEP57L1
gene id: 9483:CEP57L1
uniprot id: U3C9K5
names: Similarity
messages: Belongs to the translokin family.

9483:HMGCLL1
gene id: 9483:HMGCLL1
uniprot id: F7H8Z9
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

9483:WNT10A
gene id: 9483:WNT10A
uniprot id: F7GQE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:OGDH
gene id: 9483:OGDH
uniprot id: F6WZI4
uniprot id: F6XLN9
uniprot id: U3DCU9
uniprot id: U3FNY3
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9483:USP37
gene id: 9483:USP37
uniprot id: F7ES35
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:CCDC65
gene id: 9483:CCDC65
uniprot id: F7IT01
names: Subcellular Location Annotation
messages: flagellum axoneme

9483:VPS4A
gene id: 9483:VPS4A
uniprot id: U3DRT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9483:TM2D3
gene id: 9483:TM2D3
uniprot id: U3D2D9
uniprot id: U3EHM1
names: Subcellular Location Annotation
messages: Membrane

9483:ITPRIPL2
gene id: 9483:ITPRIPL2
uniprot id: U3CUS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9483:CYP3A4
gene id: 9483:CYP3A4
uniprot id: O18993
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

9483:PSMD1
gene id: 9483:PSMD1
uniprot id: U3ENA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9483:SLC43A1
gene id: 9483:SLC43A1
uniprot id: U3C3I7
names: Subcellular Location Annotation
messages: Membrane

9483:PPIF
gene id: 9483:PPIF
uniprot id: A0A5F4WM42
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:XPC
gene id: 9483:XPC
uniprot id: U3DIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

9483:DPH5
gene id: 9483:DPH5
uniprot id: F7ERT2
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9483:KCNC2
gene id: 9483:KCNC2
uniprot id: A0A5F4W2U6
uniprot id: A0A8I4A4L2
uniprot id: F7HVC4
uniprot id: F7HVE1
uniprot id: F7HVE2
uniprot id: F7HVE3
names: Subcellular Location Annotation
messages: Membrane

9483:RGR
gene id: 9483:RGR
uniprot id: U3CHN1
names: Subcellular Location Annotation
messages: Membrane

9483:CTNND2
gene id: 9483:CTNND2
uniprot id: A0A8I3VZA1
names: Similarity
messages: Belongs to the beta-catenin family.

9483:OR1L3
gene id: 9483:OR1L3
uniprot id: F7B0Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:KLRK1
gene id: 9483:KLRK1
uniprot id: A4GHD0
uniprot id: A4GHD1
names: Subcellular Location Annotation
messages: Cell membrane

9483:RETREG3
gene id: 9483:RETREG3
uniprot id: F7HNU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:C8B
gene id: 9483:C8B
uniprot id: F7IA58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:CYP2R1
gene id: 9483:CYP2R1
uniprot id: F7I9Q1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:ATP6AP2
gene id: 9483:ATP6AP2
uniprot id: F7GIK4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9483:KRT19
gene id: 9483:KRT19
uniprot id: U3E6V8
names: Similarity
messages: Belongs to the intermediate filament family.

9483:PRKACB
gene id: 9483:PRKACB
uniprot id: A0A2R8MZJ8
uniprot id: A0A8I3WBJ8
uniprot id: F7FX16
uniprot id: F7IA24
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9483:CPLX4
gene id: 9483:CPLX4
uniprot id: A0A5F4VUD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9483:MZT1
gene id: 9483:MZT1
uniprot id: F7F1E1
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9483:EXTL3
gene id: 9483:EXTL3
uniprot id: A0A2R8PFB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:NDEL1
gene id: 9483:NDEL1
uniprot id: A0A8I3WI93
uniprot id: U3AVW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9483:ATP8A1
gene id: 9483:ATP8A1
uniprot id: F7H2Q6
uniprot id: U3CLS5
uniprot id: U3ECZ6
uniprot id: U3EDG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9483:APH1A
gene id: 9483:APH1A
uniprot id: U3DJW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9483:LYSET
gene id: 9483:LYSET
uniprot id: A0A8I3WHR4
uniprot id: F6VKZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Membrane

9483:SLC25A46
gene id: 9483:SLC25A46
uniprot id: F7I9N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:SLC25A11
gene id: 9483:SLC25A11
uniprot id: F6RKX7
uniprot id: F7EGM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:ARSG
gene id: 9483:ARSG
uniprot id: F7G1L1
names: Similarity
messages: Belongs to the sulfatase family.

9483:TMEM170A
gene id: 9483:TMEM170A
uniprot id: F7ITE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9483:TMEM151A
gene id: 9483:TMEM151A
uniprot id: F7IQK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9483:LOC100386428
gene id: 9483:LOC100386428
uniprot id: A0A5F4WEM7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9483:PFDN4
gene id: 9483:PFDN4
uniprot id: A0A2R8MGV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9483:IRX3
gene id: 9483:IRX3
uniprot id: F7INF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9483:LVRN
gene id: 9483:LVRN
uniprot id: F6XCN7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9483:NDUFS4
gene id: 9483:NDUFS4
uniprot id: U3CCC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9483:DDX3X
gene id: 9483:DDX3X
uniprot id: F7IPC4
uniprot id: U3BPE2
uniprot id: U3F245
names: Similarity
messages: Belongs to the DEAD box helicase family.

9483:MCRIP1
gene id: 9483:MCRIP1
uniprot id: H9KVX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9483:MSRB2
gene id: 9483:MSRB2
uniprot id: U3FFK9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9483:MYO16
gene id: 9483:MYO16
uniprot id: F7ISV5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:TEX261
gene id: 9483:TEX261
uniprot id: F7GTP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9483:BROX
gene id: 9483:BROX
uniprot id: U3F6X8
names: Similarity
messages: Belongs to the BROX family.

9483:PGAM2
gene id: 9483:PGAM2
uniprot id: F7HXH1
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9483:TPRKB
gene id: 9483:TPRKB
uniprot id: U3CI83
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9483:FGF22
gene id: 9483:FGF22
uniprot id: F7G046
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:UTP25
gene id: 9483:UTP25
uniprot id: U3EH16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9483:IFI30
gene id: 9483:IFI30
uniprot id: U3EAL7
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

9483:CDKN1B
gene id: 9483:CDKN1B
uniprot id: F7HH57
names: Similarity
messages: Belongs to the CDI family.

9483:RPIA
gene id: 9483:RPIA
uniprot id: F7EL42
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9483:RPN2
gene id: 9483:RPN2
uniprot id: F7IJ88
uniprot id: U3CRS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9483:TLR1
gene id: 9483:TLR1
uniprot id: F6X7G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9483:NR4A1
gene id: 9483:NR4A1
uniprot id: U3E1S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.
messages: Nucleus
messages: cytosol

9483:FAM151B
gene id: 9483:FAM151B
uniprot id: F7GXZ1
names: Similarity
messages: Belongs to the FAM151 family.

9483:MMP23B
gene id: 9483:MMP23B
uniprot id: F7GLA7
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:NQO1
gene id: 9483:NQO1
uniprot id: A0A2R8MT21
uniprot id: F7EKA7
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9483:HPDL
gene id: 9483:HPDL
uniprot id: F7DDE2
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9483:GNAI1
gene id: 9483:GNAI1
uniprot id: F7IEH0
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9483:LOC100406098
gene id: 9483:LOC100406098
uniprot id: A0A7R8C3F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:MLLT3
gene id: 9483:MLLT3
uniprot id: A0A5F4VXF6
uniprot id: F7C404
names: Subcellular Location Annotation
messages: Nucleus

9483:IRF7
gene id: 9483:IRF7
uniprot id: U3BP84
names: Subcellular Location Annotation
messages: Nucleus

9483:ZC3H15
gene id: 9483:ZC3H15
uniprot id: U3DXN7
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9483:GC
gene id: 9483:GC
uniprot id: F7IP47
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9483:CCKAR
gene id: 9483:CCKAR
uniprot id: A0A8I3XB38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9483:CACNB3
gene id: 9483:CACNB3
uniprot id: A0A2R8MDP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9483:ARPP19
gene id: 9483:ARPP19
uniprot id: F7AF76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9483:CORO7
gene id: 9483:CORO7
uniprot id: U3CIU7
names: Similarity
messages: Belongs to the WD repeat coronin family.

9483:IL23A
gene id: 9483:IL23A
uniprot id: A0A2R8N533
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9483:AMPD1
gene id: 9483:AMPD1
uniprot id: F7I5U7
uniprot id: F7I851
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9483:BORCS8
gene id: 9483:BORCS8
uniprot id: F6QVS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

9483:PLSCR1
gene id: 9483:PLSCR1
uniprot id: U3APV7
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9483:MT2A
gene id: 9483:MT2A
uniprot id: A0A8I3WDW9
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9483:NEMP2
gene id: 9483:NEMP2
uniprot id: F7IFN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9483:RPL26
gene id: 9483:RPL26
uniprot id: F7HQ77
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:OR52E2
gene id: 9483:OR52E2
uniprot id: B0VXA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:MAPRE2
gene id: 9483:MAPRE2
uniprot id: A0A5F4W6S5
uniprot id: F7EAS4
uniprot id: F7EW78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9483:ZRANB1
gene id: 9483:ZRANB1
uniprot id: F7III3
uniprot id: U3FPZ0
names: Similarity
messages: Belongs to the peptidase C64 family.

9483:PDCL
gene id: 9483:PDCL
uniprot id: F7BIF8
names: Similarity
messages: Belongs to the phosducin family.

9483:CNIH4
gene id: 9483:CNIH4
uniprot id: F7IBF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9483:B4GALT6
gene id: 9483:B4GALT6
uniprot id: F7IDV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9483:ACKR1
gene id: 9483:ACKR1
uniprot id: E0XJE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

9483:SEPTIN7
gene id: 9483:SEPTIN7
uniprot id: F7HWN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium axoneme
messages: flagellum
messages: kinetochore
messages: spindle

9483:RSBN1
gene id: 9483:RSBN1
uniprot id: F7HUK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9483:MSX2
gene id: 9483:MSX2
uniprot id: F7I6A5
names: Subcellular Location Annotation
messages: Nucleus

9483:ZDHHC21
gene id: 9483:ZDHHC21
uniprot id: F7HUB7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:PHB1
gene id: 9483:PHB1
uniprot id: F7AH92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9483:SLC25A38
gene id: 9483:SLC25A38
uniprot id: A0A5F4VR98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9483:FAM114A2
gene id: 9483:FAM114A2
uniprot id: U3FMF4
names: Similarity
messages: Belongs to the FAM114 family.

9483:COQ7
gene id: 9483:COQ7
uniprot id: F6XXM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9483:FAR1
gene id: 9483:FAR1
uniprot id: U3E399
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9483:ATOSA
gene id: 9483:ATOSA
uniprot id: U3DKZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9483:PRPF3
gene id: 9483:PRPF3
uniprot id: U3DW67
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9483:LOC100398547
gene id: 9483:LOC100398547
uniprot id: A0A5F4VWY2
names: Similarity
messages: Belongs to the mab-21 family.

9483:PRL
gene id: 9483:PRL
uniprot id: F7ICU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9483:PGA
gene id: 9483:PGA
uniprot id: Q9N2D4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Inhibited by pepstatin.
messages: Secreted
messages: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

9483:DEDD
gene id: 9483:DEDD
uniprot id: F7GWR4
names: Subcellular Location Annotation
messages: nucleolus

9483:LOC100410987
gene id: 9483:LOC100410987
uniprot id: U3FT46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9483:AJUBA
gene id: 9483:AJUBA
uniprot id: F7GZN5
names: Similarity
messages: Belongs to the zyxin/ajuba family.

9483:SMPX
gene id: 9483:SMPX
uniprot id: F7DME5
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

9483:CD44
gene id: 9483:CD44
uniprot id: F6PQY5
uniprot id: F7FML0
uniprot id: F7ICN5
uniprot id: U3DNN5
uniprot id: U3FDP6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

9483:EPHB4
gene id: 9483:EPHB4
uniprot id: U3BYP0
names: Subcellular Location Annotation
messages: Membrane

9483:ELP2
gene id: 9483:ELP2
uniprot id: U3BWB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

9483:LOC100392617
gene id: 9483:LOC100392617
uniprot id: U3DF39
names: Similarity
messages: Belongs to the cytochrome b5 family.

9483:GOT1
gene id: 9483:GOT1
uniprot id: F7GSG3
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9483:SEC23B
gene id: 9483:SEC23B
uniprot id: F7IMB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9483:SCGN
gene id: 9483:SCGN
uniprot id: F6XL01
names: Subcellular Location Annotation
messages: secretory vesicle membrane

9483:GPR17
gene id: 9483:GPR17
uniprot id: A0A5F4VVE1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:TNFRSF10B
gene id: 9483:TNFRSF10B
uniprot id: F7CE02
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

9483:P2RX7
gene id: 9483:P2RX7
uniprot id: F7HRX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9483:SNU13
gene id: 9483:SNU13
uniprot id: H9KVU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9483:BCO1
gene id: 9483:BCO1
uniprot id: A0A8I3WVM0
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

9483:FGF3
gene id: 9483:FGF3
uniprot id: F7HVK7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:PPP1R3C
gene id: 9483:PPP1R3C
uniprot id: F7GL21
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9483:INTS2
gene id: 9483:INTS2
uniprot id: A0A8J8XMZ6
names: Similarity
messages: Belongs to the Integrator subunit 2 family.

9483:EPAS1
gene id: 9483:EPAS1
uniprot id: U3DUV3
names: Subcellular Location Annotation
messages: Nucleus speckle

9483:LBH
gene id: 9483:LBH
uniprot id: F7HVN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9483:COQ10B
gene id: 9483:COQ10B
uniprot id: A0A2R8MIC0
uniprot id: F6PJ77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9483:LOC100411216
gene id: 9483:LOC100411216
uniprot id: A0A5F4WLF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:MICOS10
gene id: 9483:MICOS10
uniprot id: A0A8I3WIY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9483:GABRG2
gene id: 9483:GABRG2
uniprot id: F6WUL1
uniprot id: F6XG46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:FOXN3
gene id: 9483:FOXN3
uniprot id: F7HBY1
uniprot id: F7HH72
uniprot id: U3AX94
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
messages: Nucleus

9483:DPM1
gene id: 9483:DPM1
uniprot id: F6RQC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9483:PDE6G
gene id: 9483:PDE6G
uniprot id: A0A2R8MS48
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9483:SNRPD1
gene id: 9483:SNRPD1
uniprot id: F7I755
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9483:HHIPL1
gene id: 9483:HHIPL1
uniprot id: A0A8J8YNE3
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:RAMAC
gene id: 9483:RAMAC
uniprot id: F7HSF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAM family.
messages: Nucleus

9483:CENPM
gene id: 9483:CENPM
uniprot id: A0A8I3W0D6
uniprot id: U3EJ69
names: Subcellular Location Annotation
messages: Nucleus

9483:CYP2C19
gene id: 9483:CYP2C19
uniprot id: A0A171P0Y8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:GRAMD1A
gene id: 9483:GRAMD1A
uniprot id: U3E5D9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:MEX3B
gene id: 9483:MEX3B
uniprot id: F7I6N7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:NIFK
gene id: 9483:NIFK
uniprot id: F6ZLL0
names: Subcellular Location Annotation
messages: nucleolus

9483:PRF1
gene id: 9483:PRF1
uniprot id: B5LX20
uniprot id: F7HFF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9483:LOC108591802
gene id: 9483:LOC108591802
uniprot id: B0VXF6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:SNX19
gene id: 9483:SNX19
uniprot id: U3DV52
names: Similarity
messages: Belongs to the sorting nexin family.

9483:HOXA2
gene id: 9483:HOXA2
uniprot id: B0VXK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Proboscipedia subfamily.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9483:HSPA5
gene id: 9483:HSPA5
uniprot id: U3FXT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cell surface
messages: Endoplasmic reticulum lumen
messages: Melanosome

9483:LSM12
gene id: 9483:LSM12
uniprot id: F6THZ7
names: Similarity
messages: Belongs to the LSM12 family.

9483:TAPT1
gene id: 9483:TAPT1
uniprot id: F7IG48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

9483:ARL6IP4
gene id: 9483:ARL6IP4
uniprot id: F6Y6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: Nucleus speckle
messages: nucleolus

9483:CD47
gene id: 9483:CD47
uniprot id: U3D367
uniprot id: U3D4H7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:MGMT
gene id: 9483:MGMT
uniprot id: U3B862
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

9483:KCNV1
gene id: 9483:KCNV1
uniprot id: F7ARX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9483:TP53INP1
gene id: 9483:TP53INP1
uniprot id: F7HJR9
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9483:TPM3
gene id: 9483:TPM3
uniprot id: A0A2R8MKU8
uniprot id: F7I9P7
uniprot id: F7IC14
uniprot id: U3DK87
uniprot id: U3EBA3
uniprot id: U3ELS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9483:GNB4
gene id: 9483:GNB4
uniprot id: F7DRF8
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9483:GSC
gene id: 9483:GSC
uniprot id: A0A2R8MTP8
names: Subcellular Location Annotation
messages: Nucleus

9483:BOD1
gene id: 9483:BOD1
uniprot id: A0A8I3VUW2
uniprot id: F7HA61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

9483:SLC16A7
gene id: 9483:SLC16A7
uniprot id: U3F5T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9483:LOC100394573
gene id: 9483:LOC100394573
uniprot id: F7G6P0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:DOK2
gene id: 9483:DOK2
uniprot id: F7CQK8
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9483:CENPT
gene id: 9483:CENPT
uniprot id: U3DEZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

9483:SDHC
gene id: 9483:SDHC
uniprot id: U3BPE5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

9483:FGF7
gene id: 9483:FGF7
uniprot id: F7IBI2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:CCR5
gene id: 9483:CCR5
uniprot id: Q9MZA0
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

9483:FRAT2
gene id: 9483:FRAT2
uniprot id: F7GHD6
names: Similarity
messages: Belongs to the GSK-3-binding protein family.

9483:IGF2
gene id: 9483:IGF2
uniprot id: F6XMS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Secreted

9483:ETHE1
gene id: 9483:ETHE1
uniprot id: U3DFU6
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9483:EIF3K
gene id: 9483:EIF3K
uniprot id: F7BZF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9483:MTF2
gene id: 9483:MTF2
uniprot id: A0A8I3W7H6
uniprot id: F7HGL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9483:DHRS7
gene id: 9483:DHRS7
uniprot id: F7IQ82
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:NR4A2
gene id: 9483:NR4A2
uniprot id: U3FW56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9483:APOA2
gene id: 9483:APOA2
uniprot id: U3CMR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein A2 family.
messages: Secreted

9483:OR52J3
gene id: 9483:OR52J3
uniprot id: B0VXA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:GRK7
gene id: 9483:GRK7
uniprot id: F7DUK2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9483:SRPX2
gene id: 9483:SRPX2
uniprot id: F7CN77
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:HM13
gene id: 9483:HM13
uniprot id: A0A8I3W7T5
uniprot id: F7IKY1
uniprot id: U3DHT5
uniprot id: U3FNG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9483:CDC42SE1
gene id: 9483:CDC42SE1
uniprot id: B0KWB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9483:TPR
gene id: 9483:TPR
uniprot id: F7IHS3
names: Similarity
messages: Belongs to the TPR family.

9483:IFNAR1
gene id: 9483:IFNAR1
uniprot id: U3CXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9483:RPL26L1
gene id: 9483:RPL26L1
uniprot id: A0A8I3W7N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane

9483:RNF135
gene id: 9483:RNF135
uniprot id: A0A8I4A0X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:RIOK2
gene id: 9483:RIOK2
uniprot id: U3D1K8
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9483:HTR4
gene id: 9483:HTR4
uniprot id: A0A5F4W988
uniprot id: U3CW94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

9483:SCPEP1
gene id: 9483:SCPEP1
uniprot id: U3FPI9
names: Similarity
messages: Belongs to the peptidase S10 family.

9483:TGFA
gene id: 9483:TGFA
uniprot id: A0A5F4VXH7
uniprot id: U3E7W0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ELAVL4
gene id: 9483:ELAVL4
uniprot id: A0A8J8Y0W4
uniprot id: F7AGG7
uniprot id: U3EU91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9483:PER2
gene id: 9483:PER2
uniprot id: U3FTY7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:RPS16
gene id: 9483:RPS16
uniprot id: F7HKF5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9483:NLE1
gene id: 9483:NLE1
uniprot id: F7GHQ8
names: Subcellular Location Annotation
messages: nucleolus

9483:PTPRCAP
gene id: 9483:PTPRCAP
uniprot id: F7CSZ1
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CD45/PTPRC.
messages: Membrane

9483:ADH1C
gene id: 9483:ADH1C
uniprot id: A0A5K1V897
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9483:PPP4C
gene id: 9483:PPP4C
uniprot id: F6S3M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9483:DGKA
gene id: 9483:DGKA
uniprot id: U3FIG2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Monomer.

9483:ATP6V0E1
gene id: 9483:ATP6V0E1
uniprot id: F7GC30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9483:CCN3
gene id: 9483:CCN3
uniprot id: F7HZ48
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:PARVG
gene id: 9483:PARVG
uniprot id: F7H433
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: Membrane

9483:SPAG9
gene id: 9483:SPAG9
uniprot id: A0A8J8YPZ1
uniprot id: U3DBD1
uniprot id: U3EVG5
uniprot id: U3F0S0
names: Similarity
messages: Belongs to the JIP scaffold family.

9483:PFDN5
gene id: 9483:PFDN5
uniprot id: F7BBE6
uniprot id: F7BTR0
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9483:SUPT20H
gene id: 9483:SUPT20H
uniprot id: F6XLY6
uniprot id: F7ATN0
names: Similarity
messages: Belongs to the SPT20 family.

9483:AKR1B10
gene id: 9483:AKR1B10
uniprot id: F7IMQ0
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9483:SEPHS1
gene id: 9483:SEPHS1
uniprot id: U3AXP7
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9483:TAF5L
gene id: 9483:TAF5L
uniprot id: U3F810
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9483:ST7
gene id: 9483:ST7
uniprot id: F7HBK2
uniprot id: Q2QLG2
uniprot id: Q2QLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9483:ITGA5
gene id: 9483:ITGA5
uniprot id: A0A8I3ZYS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9483:RCL1
gene id: 9483:RCL1
uniprot id: U3FH01
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

9483:PGS1
gene id: 9483:PGS1
uniprot id: U3EEX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9483:SBK2
gene id: 9483:SBK2
uniprot id: F7IJN5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:ICMT
gene id: 9483:ICMT
uniprot id: F7GN70
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:TRAPPC4
gene id: 9483:TRAPPC4
uniprot id: U3C2I8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9483:HSPB6
gene id: 9483:HSPB6
uniprot id: F7EBV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9483:GPR132
gene id: 9483:GPR132
uniprot id: F6T5G8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:DBX1
gene id: 9483:DBX1
uniprot id: F7FA07
names: Subcellular Location Annotation
messages: Nucleus

9483:ZNF449
gene id: 9483:ZNF449
uniprot id: F7IKZ3
names: Subcellular Location Annotation
messages: Nucleus

9483:RNF141
gene id: 9483:RNF141
uniprot id: F7GRH4
names: Function
messages: May be involved in spermatogenesis.

9483:ADD3
gene id: 9483:ADD3
uniprot id: U3C1U3
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9483:MRPL15
gene id: 9483:MRPL15
uniprot id: F6VPC6
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9483:KCTD13
gene id: 9483:KCTD13
uniprot id: U3DBP3
names: Similarity
messages: Belongs to the BACURD family.

9483:HYOU1
gene id: 9483:HYOU1
uniprot id: U3FHE6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9483:LOC103795964
gene id: 9483:LOC103795964
uniprot id: U3DJ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: Mitochondrion inner membrane

9483:SLC19A2
gene id: 9483:SLC19A2
uniprot id: F7HG40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9483:PNPT1
gene id: 9483:PNPT1
uniprot id: F7GWJ1
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

9483:CHN2
gene id: 9483:CHN2
uniprot id: U3CK98
names: Function
messages: GTPase-activating protein for p21-rac.

9483:PNRC1
gene id: 9483:PNRC1
uniprot id: F7AHG5
names: Subcellular Location Annotation
messages: Nucleus

9483:CDK2
gene id: 9483:CDK2
uniprot id: F7BWH8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:CAMK2N1
gene id: 9483:CAMK2N1
uniprot id: F7GNI1
names: Similarity
messages: Belongs to the CAMK2N family.

9483:DHRS3
gene id: 9483:DHRS3
uniprot id: U3D2B1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:NPY5R
gene id: 9483:NPY5R
uniprot id: U3DXT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

9483:BTF3
gene id: 9483:BTF3
uniprot id: F6WAJ8
names: Similarity
messages: Belongs to the NAC-beta family.

9483:SLC31A1
gene id: 9483:SLC31A1
uniprot id: U3B0D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9483:SF3A2
gene id: 9483:SF3A2
uniprot id: U3E527
names: Similarity
messages: Belongs to the SF3A2 family.

9483:LIN54
gene id: 9483:LIN54
uniprot id: A0A5F4W2W1
uniprot id: F7GXH3
uniprot id: F7H2K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9483:TMEM106C
gene id: 9483:TMEM106C
uniprot id: F7DTI0
names: Similarity
messages: Belongs to the TMEM106 family.

9483:MTCH1
gene id: 9483:MTCH1
uniprot id: F7FJW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:SERPINE1
gene id: 9483:SERPINE1
uniprot id: F7I5C2
names: Similarity
messages: Belongs to the serpin family.

9483:MARVELD1
gene id: 9483:MARVELD1
uniprot id: F7A5C4
names: Subcellular Location Annotation
messages: Membrane

9483:ST13
gene id: 9483:ST13
uniprot id: F7HT98
names: Similarity
messages: Belongs to the FAM10 family.

9483:DEUP1
gene id: 9483:DEUP1
uniprot id: F7EP69
names: Similarity
messages: Belongs to the CEP63 family.

9483:LIN9
gene id: 9483:LIN9
uniprot id: F7II53
uniprot id: U3DP36
names: Similarity
messages: Belongs to the lin-9 family.

9483:GFRA1
gene id: 9483:GFRA1
uniprot id: F7DLH5
uniprot id: U3CT67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9483:ORC5
gene id: 9483:ORC5
uniprot id: F7I1U2
names: Subcellular Location Annotation
messages: Nucleus

9483:ABRAXAS1
gene id: 9483:ABRAXAS1
uniprot id: U3D986
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Nucleus

9483:LRRFIP2
gene id: 9483:LRRFIP2
uniprot id: U3B8X9
uniprot id: U3CUM9
names: Similarity
messages: Belongs to the LRRFIP family.

9483:MAT2A
gene id: 9483:MAT2A
uniprot id: F7F996
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9483:RC3H1
gene id: 9483:RC3H1
uniprot id: F6YKI3
names: Subcellular Location Annotation
messages: P-body

9483:RAB9B
gene id: 9483:RAB9B
uniprot id: F7GKL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9483:GPHB5
gene id: 9483:GPHB5
uniprot id: F7HI76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9483:DPP7
gene id: 9483:DPP7
uniprot id: F7EFW5
names: Similarity
messages: Belongs to the peptidase S28 family.

9483:SETDB1
gene id: 9483:SETDB1
uniprot id: U3DWM7
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9483:C11H11orf87
gene id: 9483:C11H11orf87
uniprot id: F7GQ18
names: Subcellular Location Annotation
messages: Membrane

9483:CHSY3
gene id: 9483:CHSY3
uniprot id: F7GS31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9483:CALHM4
gene id: 9483:CALHM4
uniprot id: F7HNE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9483:MYADM
gene id: 9483:MYADM
uniprot id: F6ZUF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

9483:PDE4B
gene id: 9483:PDE4B
uniprot id: F7IJN3
uniprot id: U3DD68
uniprot id: U3FTI7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:HNRNPR
gene id: 9483:HNRNPR
uniprot id: U3FR96
names: Subcellular Location Annotation
messages: Cytoplasm

9483:TAFA1
gene id: 9483:TAFA1
uniprot id: U3CAK2
names: Similarity
messages: Belongs to the TAFA family.

9483:MAL
gene id: 9483:MAL
uniprot id: F7HP25
names: Subcellular Location Annotation
messages: Membrane

9483:SNX10
gene id: 9483:SNX10
uniprot id: A0A8I3WPZ9
uniprot id: F7IN97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9483:FOXC2
gene id: 9483:FOXC2
uniprot id: A0A2R8MRM9
names: Subcellular Location Annotation
messages: Nucleus

9483:AGO1
gene id: 9483:AGO1
uniprot id: U3DP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9483:NCOA2
gene id: 9483:NCOA2
uniprot id: F7C3B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9483:CARMIL1
gene id: 9483:CARMIL1
uniprot id: U3DPX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9483:TDO2
gene id: 9483:TDO2
uniprot id: F7GQ44
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:UCN3
gene id: 9483:UCN3
uniprot id: H9KVL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9483:CCNDBP1
gene id: 9483:CCNDBP1
uniprot id: F7I304
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

9483:ESD
gene id: 9483:ESD
uniprot id: U3DYQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9483:LAMB1
gene id: 9483:LAMB1
uniprot id: U3E535
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9483:ACVRL1
gene id: 9483:ACVRL1
uniprot id: U3FJW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9483:ATP6V1C2
gene id: 9483:ATP6V1C2
uniprot id: U3DCW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9483:CCND2
gene id: 9483:CCND2
uniprot id: F7I947
names: Similarity
messages: Belongs to the cyclin family.

9483:MTCH2
gene id: 9483:MTCH2
uniprot id: F6VE72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:CCDC167
gene id: 9483:CCDC167
uniprot id: U3DSM4
names: Subcellular Location Annotation
messages: Membrane

9483:DOK4
gene id: 9483:DOK4
uniprot id: A0A5F4WCM8
uniprot id: U3DIP2
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9483:ACTG2
gene id: 9483:ACTG2
uniprot id: F6PL61
names: Similarity
messages: Belongs to the actin family.

9483:LOC100394162
gene id: 9483:LOC100394162
uniprot id: F6RZ51
names: Similarity
messages: Belongs to the intermediate filament family.

9483:PLIN2
gene id: 9483:PLIN2
uniprot id: A0A8I3WQ03
names: Similarity
messages: Belongs to the perilipin family.

9483:MYO1E
gene id: 9483:MYO1E
uniprot id: U3BT73
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:PHAX
gene id: 9483:PHAX
uniprot id: F7DJT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

9483:SEC61A2
gene id: 9483:SEC61A2
uniprot id: A0A8I3WE13
uniprot id: H9KXE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:PNN
gene id: 9483:PNN
uniprot id: U3BJN4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

9483:CPD
gene id: 9483:CPD
uniprot id: U3FTT0
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:VWA2
gene id: 9483:VWA2
uniprot id: F7E354
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:DESI2
gene id: 9483:DESI2
uniprot id: U3C837
names: Similarity
messages: Belongs to the DeSI family.

9483:IER3IP1
gene id: 9483:IER3IP1
uniprot id: F7HTN1
names: Similarity
messages: Belongs to the YOS1 family.

9483:LAPTM4A
gene id: 9483:LAPTM4A
uniprot id: U3EDB3
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9483:ZNF500
gene id: 9483:ZNF500
uniprot id: F6Q7P6
names: Subcellular Location Annotation
messages: Nucleus

9483:CDKN2AIPNL
gene id: 9483:CDKN2AIPNL
uniprot id: A0A8I3VY68
names: Similarity
messages: Belongs to the CARF family.

9483:ANAPC16
gene id: 9483:ANAPC16
uniprot id: F6X634
uniprot id: U3CQN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9483:GPX7
gene id: 9483:GPX7
uniprot id: F7I0C6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9483:ID1
gene id: 9483:ID1
uniprot id: U3EVS0
names: Subcellular Location Annotation
messages: Nucleus

9483:USP45
gene id: 9483:USP45
uniprot id: F7I295
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:GSTZ1
gene id: 9483:GSTZ1
uniprot id: A0A7G0XAN9
uniprot id: A0A8I3WCX3
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9483:TRIM35
gene id: 9483:TRIM35
uniprot id: A0A5F4WL92
uniprot id: U3FRK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:STXBP3
gene id: 9483:STXBP3
uniprot id: U3D3M4
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9483:FGB
gene id: 9483:FGB
uniprot id: F7FU68
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9483:METTL1
gene id: 9483:METTL1
uniprot id: U3D6D9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with WDR4.
messages: Nucleus
messages: Phosphorylation at Ser-27 inactivates its catalytic activity but does not affect the interaction with WDR4.

9483:TMEM147
gene id: 9483:TMEM147
uniprot id: F7GQ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM147 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

9483:PTPN12
gene id: 9483:PTPN12
uniprot id: A0A8J8Y1V2
uniprot id: F7IB84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

9483:CETN2
gene id: 9483:CETN2
uniprot id: F6RHT8
names: Similarity
messages: Belongs to the centrin family.

9483:TMPRSS3
gene id: 9483:TMPRSS3
uniprot id: F6WH39
uniprot id: U3C5P2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CMC1
gene id: 9483:CMC1
uniprot id: U3CEM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9483:PPP2R5E
gene id: 9483:PPP2R5E
uniprot id: F7DEZ3
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9483:BRI3
gene id: 9483:BRI3
uniprot id: F6UK70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

9483:POLB
gene id: 9483:POLB
uniprot id: F7IKW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9483:RAB21
gene id: 9483:RAB21
uniprot id: U3DY75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: trans-Golgi network

9483:HNRNPF
gene id: 9483:HNRNPF
uniprot id: U3DCZ9
names: Subcellular Location Annotation
messages: nucleoplasm

9483:UPP1
gene id: 9483:UPP1
uniprot id: F7FUA4
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9483:NATD1
gene id: 9483:NATD1
uniprot id: H9KXF9
names: Similarity
messages: Belongs to the NATD1 family.

9483:VANGL2
gene id: 9483:VANGL2
uniprot id: U3BVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9483:RNGTT
gene id: 9483:RNGTT
uniprot id: A0A5F4VXZ2
uniprot id: F7BIR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9483:PPP2CA
gene id: 9483:PPP2CA
uniprot id: U3DKU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9483:GPR180
gene id: 9483:GPR180
uniprot id: A0A2R8P4S7
names: Subcellular Location Annotation
messages: Membrane

9483:CD53
gene id: 9483:CD53
uniprot id: A0A8I3WAT5
uniprot id: F7HHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:RSPO2
gene id: 9483:RSPO2
uniprot id: U3DVW2
names: Similarity
messages: Belongs to the R-spondin family.

9483:ST6GALNAC3
gene id: 9483:ST6GALNAC3
uniprot id: A0A8I4A5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:ANAPC15
gene id: 9483:ANAPC15
uniprot id: U3C3A1
uniprot id: U3EFC7
names: Similarity
messages: Belongs to the APC15 family.

9483:APTX
gene id: 9483:APTX
uniprot id: A0A8I3WXG5
uniprot id: F7IIK3
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

9483:CNOT7
gene id: 9483:CNOT7
uniprot id: F6QE98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9483:LPAR4
gene id: 9483:LPAR4
uniprot id: A0A2R8PF80
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:TSPAN8
gene id: 9483:TSPAN8
uniprot id: U3BGL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:FAM53A
gene id: 9483:FAM53A
uniprot id: U3DKY1
names: Similarity
messages: Belongs to the FAM53 family.

9483:UBE2B
gene id: 9483:UBE2B
uniprot id: F7HM77
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:KRT36
gene id: 9483:KRT36
uniprot id: F7C5X7
names: Similarity
messages: Belongs to the intermediate filament family.

9483:USP22
gene id: 9483:USP22
uniprot id: U3DA34
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:TIMM50
gene id: 9483:TIMM50
uniprot id: F7ITE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

9483:ATXN1L
gene id: 9483:ATXN1L
uniprot id: F6RTB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9483:LOC103794361
gene id: 9483:LOC103794361
uniprot id: A0A2R8PB71
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9483:IFNGR1
gene id: 9483:IFNGR1
uniprot id: U3FIJ0
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9483:RHOT1
gene id: 9483:RHOT1
uniprot id: A0A8J8XLS4
uniprot id: A0A8J8XUP8
uniprot id: A0A8J8XY62
uniprot id: F7I728
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9483:LMBR1L
gene id: 9483:LMBR1L
uniprot id: U3DXH0
names: Similarity
messages: Belongs to the LIMR family.

9483:CHD1
gene id: 9483:CHD1
uniprot id: U3E1Z5
names: Subcellular Location Annotation
messages: Nucleus

9483:CLCN3
gene id: 9483:CLCN3
uniprot id: U3EFY2
uniprot id: U3EGL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9483:TAF7
gene id: 9483:TAF7
uniprot id: F6SLI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9483:ST6GALNAC6
gene id: 9483:ST6GALNAC6
uniprot id: F7A279
uniprot id: U3DSI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:IFRD2
gene id: 9483:IFRD2
uniprot id: F7IB11
names: Similarity
messages: Belongs to the IFRD family.

9483:LOC100415497
gene id: 9483:LOC100415497
uniprot id: F7EDV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PRDM5
gene id: 9483:PRDM5
uniprot id: A0A2R8MPV1
names: Subcellular Location Annotation
messages: Nucleus

9483:RNASE6
gene id: 9483:RNASE6
uniprot id: F7HRN4
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9483:PDX1
gene id: 9483:PDX1
uniprot id: A0A8I3X1E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9483:TSC22D1
gene id: 9483:TSC22D1
uniprot id: A0A8I3W8C9
uniprot id: A0A8I3W8P6
uniprot id: F6TA11
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9483:HEBP2
gene id: 9483:HEBP2
uniprot id: F7HWX4
names: Similarity
messages: Belongs to the HEBP family.

9483:COR51P3
gene id: 9483:COR51P3
uniprot id: B0VXA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:NCK2
gene id: 9483:NCK2
uniprot id: F7HUY1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9483:RCAN2
gene id: 9483:RCAN2
uniprot id: U3DR93
uniprot id: U3F3B1
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9483:GOLPH3L
gene id: 9483:GOLPH3L
uniprot id: F7H8H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9483:SDC2
gene id: 9483:SDC2
uniprot id: F7IT99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9483:NFE2L2
gene id: 9483:NFE2L2
uniprot id: U3CIU3
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9483:PPP3R1
gene id: 9483:PPP3R1
uniprot id: F7GNF2
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9483:GNAT3
gene id: 9483:GNAT3
uniprot id: F7IEF2
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9483:APOA5
gene id: 9483:APOA5
uniprot id: B0KWQ9
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9483:GOT2
gene id: 9483:GOT2
uniprot id: F7GQT4
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9483:CSK
gene id: 9483:CSK
uniprot id: U3BXQ3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:BRIX1
gene id: 9483:BRIX1
uniprot id: F6YS13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9483:NAA35
gene id: 9483:NAA35
uniprot id: U3CWU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9483:LOC100389034
gene id: 9483:LOC100389034
uniprot id: A0A8I4A4Y0
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9483:PTTG1
gene id: 9483:PTTG1
uniprot id: F7E3V6
uniprot id: U3FLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9483:PHF20
gene id: 9483:PHF20
uniprot id: F6THN4
names: Subcellular Location Annotation
messages: Nucleus

9483:EMC8
gene id: 9483:EMC8
uniprot id: A0A8I3W6A1
uniprot id: F7IA18
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9483:TOE1
gene id: 9483:TOE1
uniprot id: F7IFC9
names: Similarity
messages: Belongs to the CAF1 family.

9483:MAEL
gene id: 9483:MAEL
uniprot id: F7ICG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9483:MMS19
gene id: 9483:MMS19
uniprot id: U3C261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9483:GRM7
gene id: 9483:GRM7
uniprot id: F7IRR1
uniprot id: U3ERT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9483:MRPS15
gene id: 9483:MRPS15
uniprot id: U3F4J6
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9483:SFT2D2
gene id: 9483:SFT2D2
uniprot id: F7I138
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9483:GNRHR
gene id: 9483:GNRHR
uniprot id: A0A2R8M762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PISD
gene id: 9483:PISD
uniprot id: B0KWR7
uniprot id: F7GK51
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9483:UBIAD1
gene id: 9483:UBIAD1
uniprot id: U3EFD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9483:NSUN2
gene id: 9483:NSUN2
uniprot id: F6Y709
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9483:SAA4
gene id: 9483:SAA4
uniprot id: A0A8I3WMR8
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9483:ETF1
gene id: 9483:ETF1
uniprot id: U3FM72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9483:RSRP1
gene id: 9483:RSRP1
uniprot id: U3BF28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSRP family.
messages: Nucleus
messages: Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.

9483:VWC2
gene id: 9483:VWC2
uniprot id: F7CDJ2
names: Subcellular Location Annotation
messages: Synapse

9483:GALNT6
gene id: 9483:GALNT6
uniprot id: F6R4R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:MED26
gene id: 9483:MED26
uniprot id: F7CC97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

9483:TOMM20
gene id: 9483:TOMM20
uniprot id: F6TRU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:LOC100894850
gene id: 9483:LOC100894850
uniprot id: A0A8I3VX86
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9483:FIS1
gene id: 9483:FIS1
uniprot id: F6UJN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

9483:BIRC2
gene id: 9483:BIRC2
uniprot id: U3D8L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9483:RNF8
gene id: 9483:RNF8
uniprot id: F6YTA4
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9483:SMIM7
gene id: 9483:SMIM7
uniprot id: U3DUY0
names: Similarity
messages: Belongs to the SMIM7 family.

9483:CDYL
gene id: 9483:CDYL
uniprot id: U3BH98
names: Subcellular Location Annotation
messages: Nucleus

9483:ACP7
gene id: 9483:ACP7
uniprot id: F7BW71
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9483:LOC100405984
gene id: 9483:LOC100405984
uniprot id: A0A2R8MJ11
uniprot id: A0A5K1UBD5
uniprot id: A0A7G0Y579
uniprot id: A0A7G3HP95
uniprot id: B0KW78
uniprot id: F7CQQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9483:UCP3
gene id: 9483:UCP3
uniprot id: A0A2R8MR09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:TRIM44
gene id: 9483:TRIM44
uniprot id: A0A8I3WIK4
names: Subcellular Location Annotation
messages: Cytoplasm

9483:TMEM177
gene id: 9483:TMEM177
uniprot id: F7I6M8
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

9483:CBR1
gene id: 9483:CBR1
uniprot id: U3BU94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9483:NPRL2
gene id: 9483:NPRL2
uniprot id: F7EGD3
names: Similarity
messages: Belongs to the NPR2 family.

9483:JAK1
gene id: 9483:JAK1
uniprot id: U3BR01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system

9483:EIF5
gene id: 9483:EIF5
uniprot id: A0A5F4WHF4
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9483:NDUFA5
gene id: 9483:NDUFA5
uniprot id: F7GKU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:RSBN1L
gene id: 9483:RSBN1L
uniprot id: F7I6G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9483:TMEM126A
gene id: 9483:TMEM126A
uniprot id: F7II27
uniprot id: U3D466
names: Subcellular Location Annotation
messages: Membrane

9483:ALKBH7
gene id: 9483:ALKBH7
uniprot id: U3CWP8
names: Similarity
messages: Belongs to the alkB family.

9483:POU4F3
gene id: 9483:POU4F3
uniprot id: A0A8I3WMQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9483:SLC6A1
gene id: 9483:SLC6A1
uniprot id: U3ENW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9483:CDH11
gene id: 9483:CDH11
uniprot id: U3ESL0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:FABP1
gene id: 9483:FABP1
uniprot id: F7FL19
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9483:CLK2
gene id: 9483:CLK2
uniprot id: F7H9U4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:RBBP5
gene id: 9483:RBBP5
uniprot id: U3DAP2
uniprot id: U3DM12
names: Subcellular Location Annotation
messages: Nucleus

9483:SLC24A4
gene id: 9483:SLC24A4
uniprot id: F6PIT7
uniprot id: U3D277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9483:RGS4
gene id: 9483:RGS4
uniprot id: F6RJK3
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9483:SLC66A2
gene id: 9483:SLC66A2
uniprot id: U3DGM0
uniprot id: U3DRZ3
names: Subcellular Location Annotation
messages: Membrane

9483:TMEFF2
gene id: 9483:TMEFF2
uniprot id: U3ETB1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SERPINB2
gene id: 9483:SERPINB2
uniprot id: B0CMA9
names: Similarity
messages: Belongs to the serpin family.

9483:MTX3
gene id: 9483:MTX3
uniprot id: A0A8I3X2L5
uniprot id: F7EW54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:NTN4
gene id: 9483:NTN4
uniprot id: F6UDK1
uniprot id: U3CXF1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CCND3
gene id: 9483:CCND3
uniprot id: F6XJP1
names: Similarity
messages: Belongs to the cyclin family.

9483:XPO5
gene id: 9483:XPO5
uniprot id: F6YW59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9483:ERI1
gene id: 9483:ERI1
uniprot id: U3B7N9
names: Subcellular Location Annotation
messages: Cytoplasm

9483:MAK16
gene id: 9483:MAK16
uniprot id: F7IJ04
names: Similarity
messages: Belongs to the MAK16 family.

9483:NOVA1
gene id: 9483:NOVA1
uniprot id: A0A8J8YB89
uniprot id: F7HNQ2
uniprot id: U3E811
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus

9483:CACNG3
gene id: 9483:CACNG3
uniprot id: F7HXI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9483:SEMA3C
gene id: 9483:SEMA3C
uniprot id: F7GWN2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:PCOLCE2
gene id: 9483:PCOLCE2
uniprot id: U3B985
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:CXCL6
gene id: 9483:CXCL6
uniprot id: A0A2R8N9E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:COX11
gene id: 9483:COX11
uniprot id: U3DRV0
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

9483:UQCC
gene id: 9483:UQCC
uniprot id: U3C6V7
names: Similarity
messages: Belongs to the CBP3 family.

9483:VPS37A
gene id: 9483:VPS37A
uniprot id: U3CKF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9483:PYCR2
gene id: 9483:PYCR2
uniprot id: L7N0W5
uniprot id: U3CV44
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9483:RNF170
gene id: 9483:RNF170
uniprot id: U3CM22
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:INSL6
gene id: 9483:INSL6
uniprot id: F7CZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9483:INPP4A
gene id: 9483:INPP4A
uniprot id: F6W0Q3
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9483:SOAT2
gene id: 9483:SOAT2
uniprot id: F6T271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:TERF1
gene id: 9483:TERF1
uniprot id: F7IQX2
uniprot id: F7IQX6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

9483:CPEB3
gene id: 9483:CPEB3
uniprot id: A0A8I3XDC5
names: Similarity
messages: Belongs to the RRM CPEB family.

9483:DDX18
gene id: 9483:DDX18
uniprot id: U3F396
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9483:GSTM3
gene id: 9483:GSTM3
uniprot id: F6TIC3
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9483:TAF12
gene id: 9483:TAF12
uniprot id: A0A2R8MY15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9483:SFRP5
gene id: 9483:SFRP5
uniprot id: F6ZL04
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TMEM131
gene id: 9483:TMEM131
uniprot id: A0A8I3X1T4
uniprot id: F6TUN3
names: Similarity
messages: Belongs to the TMEM131 family.

9483:SRP72
gene id: 9483:SRP72
uniprot id: U3CLM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

9483:SP4
gene id: 9483:SP4
uniprot id: A0A2R8ME16
names: Subcellular Location Annotation
messages: Nucleus

9483:MRPL3
gene id: 9483:MRPL3
uniprot id: A0A2R8PK74
uniprot id: F7IC72
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9483:NDFIP2
gene id: 9483:NDFIP2
uniprot id: A0A5F4VQP6
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9483:QPCT
gene id: 9483:QPCT
uniprot id: A0A8I3X3E4
uniprot id: F6PIC3
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9483:BTAF1
gene id: 9483:BTAF1
uniprot id: A0A2R8MUK8
names: Subcellular Location Annotation
messages: Nucleus

9483:EFNA4
gene id: 9483:EFNA4
uniprot id: F7A539
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:IRF2BP1
gene id: 9483:IRF2BP1
uniprot id: U3CWM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9483:PIK3CB
gene id: 9483:PIK3CB
uniprot id: F7CM33
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9483:NHEJ1
gene id: 9483:NHEJ1
uniprot id: U3EJC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

9483:DUOXA1
gene id: 9483:DUOXA1
uniprot id: U3ARF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9483:PLAT
gene id: 9483:PLAT
uniprot id: F7HV58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:TBCA
gene id: 9483:TBCA
uniprot id: F7HGE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9483:ZCCHC4
gene id: 9483:ZCCHC4
uniprot id: U3C004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9483:LOC108589623
gene id: 9483:LOC108589623
uniprot id: F7FDP2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9483:RABAC1
gene id: 9483:RABAC1
uniprot id: F7I8Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9483:SLC17A6
gene id: 9483:SLC17A6
uniprot id: U3C834
names: Subcellular Location Annotation
messages: Membrane

9483:NDUFV1
gene id: 9483:NDUFV1
uniprot id: U3BG69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9483:PPP3CA
gene id: 9483:PPP3CA
uniprot id: U3B0P1
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9483:TMED10
gene id: 9483:TMED10
uniprot id: U3ED30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:GHSR
gene id: 9483:GHSR
uniprot id: A5A4L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC100397482
gene id: 9483:LOC100397482
uniprot id: U3CM30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:SUGCT
gene id: 9483:SUGCT
uniprot id: U3CGC2
names: Similarity
messages: Belongs to the CoA-transferase III family.

9483:SGPL1
gene id: 9483:SGPL1
uniprot id: U3DE76
names: Similarity
messages: Belongs to the group II decarboxylase family.

9483:NKX2-2
gene id: 9483:NKX2-2
uniprot id: F7I8G9
names: Subcellular Location Annotation
messages: Nucleus

9483:PPIL1
gene id: 9483:PPIL1
uniprot id: A0A8I4A5R6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:SMDT1
gene id: 9483:SMDT1
uniprot id: H9KVS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9483:RFT1
gene id: 9483:RFT1
uniprot id: U3D1L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

9483:MACIR
gene id: 9483:MACIR
uniprot id: F7BMU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9483:OTOP3
gene id: 9483:OTOP3
uniprot id: F7G708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9483:ANKH
gene id: 9483:ANKH
uniprot id: F7D3S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9483:HENMT1
gene id: 9483:HENMT1
uniprot id: U3DYW0
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9483:RWDD3
gene id: 9483:RWDD3
uniprot id: U3E9M5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:HOMER1
gene id: 9483:HOMER1
uniprot id: F6T045
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9483:NRG1
gene id: 9483:NRG1
uniprot id: A0A2R8MUP3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CRYBA4
gene id: 9483:CRYBA4
uniprot id: F7GZ12
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9483:HOXD10
gene id: 9483:HOXD10
uniprot id: F7G643
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9483:NOSTRIN
gene id: 9483:NOSTRIN
uniprot id: A0A8I3W1J0
names: Subcellular Location Annotation
messages: cytoskeleton

9483:COG3
gene id: 9483:COG3
uniprot id: U3FGZ3
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9483:PIGO
gene id: 9483:PIGO
uniprot id: U3F7U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:BARHL2
gene id: 9483:BARHL2
uniprot id: F7CVL1
names: Subcellular Location Annotation
messages: Nucleus

9483:KIFBP
gene id: 9483:KIFBP
uniprot id: F7HIC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

9483:TET3
gene id: 9483:TET3
uniprot id: F7GQB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9483:GTF2F2
gene id: 9483:GTF2F2
uniprot id: U3CFI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9483:DGKG
gene id: 9483:DGKG
uniprot id: A0A8J8XUE2
uniprot id: F7GI17
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9483:ITM2A
gene id: 9483:ITM2A
uniprot id: U3DP04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9483:POLR3A
gene id: 9483:POLR3A
uniprot id: A0A8I3WWW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9483:ARR3
gene id: 9483:ARR3
uniprot id: F7IME6
names: Similarity
messages: Belongs to the arrestin family.

9483:LPGAT1
gene id: 9483:LPGAT1
uniprot id: U3E0V8
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9483:EMG1
gene id: 9483:EMG1
uniprot id: F6YHU5
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9483:SNX9
gene id: 9483:SNX9
uniprot id: U3EQV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9483:RAD21
gene id: 9483:RAD21
uniprot id: F7HYV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9483:SYNM
gene id: 9483:SYNM
uniprot id: U3BFC6
uniprot id: U3C005
names: Similarity
messages: Belongs to the intermediate filament family.

9483:PRLR
gene id: 9483:PRLR
uniprot id: F7BTT9
uniprot id: Q9N0J7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9483:DOCK3
gene id: 9483:DOCK3
uniprot id: U3FQQ1
names: Similarity
messages: Belongs to the DOCK family.

9483:ZDHHC20
gene id: 9483:ZDHHC20
uniprot id: U3F9W8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:CXCR1
gene id: 9483:CXCR1
uniprot id: A0A2R8N9I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC100411174
gene id: 9483:LOC100411174
uniprot id: A0A8I3WKB8
names: Similarity
messages: Belongs to the actin family.

9483:AMDHD1
gene id: 9483:AMDHD1
uniprot id: A0A8I4A0F1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

9483:TRAPPC3
gene id: 9483:TRAPPC3
uniprot id: A0A2R8NCA5
uniprot id: U3EHE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9483:MFAP5
gene id: 9483:MFAP5
uniprot id: U3DPH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

9483:LIFR
gene id: 9483:LIFR
uniprot id: U3C6U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9483:EXOC5
gene id: 9483:EXOC5
uniprot id: F7I3U0
names: Similarity
messages: Belongs to the SEC10 family.

9483:RPS23
gene id: 9483:RPS23
uniprot id: F7H6F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Rough endoplasmic reticulum

9483:EIF2B4
gene id: 9483:EIF2B4
uniprot id: F7E415
uniprot id: U3D8F9
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9483:GPAM
gene id: 9483:GPAM
uniprot id: A0A8I3W879
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9483:CACUL1
gene id: 9483:CACUL1
uniprot id: F7GMU9
names: Similarity
messages: Belongs to the cullin family.

9483:MAP2K5
gene id: 9483:MAP2K5
uniprot id: A0A8I3W005
uniprot id: F7EJV6
uniprot id: F7GFU7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:TBL1X
gene id: 9483:TBL1X
uniprot id: A0A5F4W3X1
names: Similarity
messages: Belongs to the WD repeat EBI family.

9483:SPPL2A
gene id: 9483:SPPL2A
uniprot id: A0A8I3W3L8
uniprot id: A0A8I3WJM1
uniprot id: U3DW22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9483:FAM120B
gene id: 9483:FAM120B
uniprot id: A0A8I3W7S6
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9483:GIPC2
gene id: 9483:GIPC2
uniprot id: F7CET3
names: Similarity
messages: Belongs to the GIPC family.

9483:MAPK7
gene id: 9483:MAPK7
uniprot id: U3BIE1
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9483:PTPRM
gene id: 9483:PTPRM
uniprot id: U3DG90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9483:MANBAL
gene id: 9483:MANBAL
uniprot id: U3CSW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9483:NOL11
gene id: 9483:NOL11
uniprot id: F7GSB7
names: Subcellular Location Annotation
messages: nucleolus

9483:GPRC5C
gene id: 9483:GPRC5C
uniprot id: F7GH50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:TFPI
gene id: 9483:TFPI
uniprot id: U3E227
names: Subcellular Location Annotation
messages: Secreted

9483:DAD1
gene id: 9483:DAD1
uniprot id: U3CZS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9483:RPS20
gene id: 9483:RPS20
uniprot id: U3ECY8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9483:RAB38
gene id: 9483:RAB38
uniprot id: F7FQR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9483:UNC119B
gene id: 9483:UNC119B
uniprot id: F7IL48
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9483:ESRRB
gene id: 9483:ESRRB
uniprot id: F7IDY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9483:SCGB1A1
gene id: 9483:SCGB1A1
uniprot id: F7I6D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9483:DDA1
gene id: 9483:DDA1
uniprot id: A0A8I3WNF3
names: Similarity
messages: Belongs to the DDA1 family.

9483:IL1A
gene id: 9483:IL1A
uniprot id: F6VT34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Secreted

9483:EEF1AKMT1
gene id: 9483:EEF1AKMT1
uniprot id: F7I5P1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9483:RPF1
gene id: 9483:RPF1
uniprot id: F7CAZ0
names: Subcellular Location Annotation
messages: nucleolus

9483:LOC108590593
gene id: 9483:LOC108590593
uniprot id: F7H244
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9483:NAA25
gene id: 9483:NAA25
uniprot id: F7IPZ6
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

9483:CCNJ
gene id: 9483:CCNJ
uniprot id: F6YW04
uniprot id: F7I9P2
names: Similarity
messages: Belongs to the cyclin family.

9483:TMEM38A
gene id: 9483:TMEM38A
uniprot id: U3DTE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9483:SERINC1
gene id: 9483:SERINC1
uniprot id: U3E8Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9483:YOD1
gene id: 9483:YOD1
uniprot id: F7CPY9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9483:DNASE1L1
gene id: 9483:DNASE1L1
uniprot id: B0KWW7
names: Similarity
messages: Belongs to the DNase I family.

9483:EFNA3
gene id: 9483:EFNA3
uniprot id: F6ZM25
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:LOC100410976
gene id: 9483:LOC100410976
uniprot id: B0VXB4
names: Similarity
messages: Belongs to the globin family.

9483:CSTB
gene id: 9483:CSTB
uniprot id: U3EM28
names: Similarity
messages: Belongs to the cystatin family.

9483:NFIA
gene id: 9483:NFIA
uniprot id: A0A2R8M331
uniprot id: A0A8I3WQB5
uniprot id: F7I562
uniprot id: U3CME0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9483:MEGF10
gene id: 9483:MEGF10
uniprot id: F7H7X5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:DENND10
gene id: 9483:DENND10
uniprot id: U3CI95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

9483:MYO1D
gene id: 9483:MYO1D
uniprot id: F7IG85
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:CCL28
gene id: 9483:CCL28
uniprot id: A0A8I3WF05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:PPEF1
gene id: 9483:PPEF1
uniprot id: A0A5F4VSH6
names: Similarity
messages: Belongs to the PPP phosphatase family.

9483:MIPEP
gene id: 9483:MIPEP
uniprot id: F7IG38
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9483:TMBIM4
gene id: 9483:TMBIM4
uniprot id: U3DZ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9483:INSL3
gene id: 9483:INSL3
uniprot id: O97937
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Highest expression in the Leydig cells of the testis.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).

9483:ACTR3B
gene id: 9483:ACTR3B
uniprot id: U3FMY2
names: Similarity
messages: Belongs to the actin family.

9483:LPCAT3
gene id: 9483:LPCAT3
uniprot id: U3BQ17
names: Subcellular Location Annotation
messages: Membrane

9483:CERCAM
gene id: 9483:CERCAM
uniprot id: F6UXA1
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9483:IL21
gene id: 9483:IL21
uniprot id: F7I3A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9483:IL2
gene id: 9483:IL2
uniprot id: Q0PIT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9483:CYP27A1
gene id: 9483:CYP27A1
uniprot id: A0A7G0X095
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:LOC100399426
gene id: 9483:LOC100399426
uniprot id: F7G6P0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:SLC2A8
gene id: 9483:SLC2A8
uniprot id: F6SK66
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9483:SMC3
gene id: 9483:SMC3
uniprot id: U3DCF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

9483:NRG3
gene id: 9483:NRG3
uniprot id: A0A2R8MMV8
uniprot id: A0A2R8MX98
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PSPC1
gene id: 9483:PSPC1
uniprot id: F7I3U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSPC family.
messages: Cytoplasm
messages: Nucleus matrix
messages: Nucleus speckle
messages: nucleolus

9483:HS2ST1
gene id: 9483:HS2ST1
uniprot id: U3BYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:CLTB
gene id: 9483:CLTB
uniprot id: F7ID71
uniprot id: F7ID77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9483:LOC100404679
gene id: 9483:LOC100404679
uniprot id: A0A2R8MU93
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.

9483:ST6GALNAC2
gene id: 9483:ST6GALNAC2
uniprot id: F7H4E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:ST8SIA4
gene id: 9483:ST8SIA4
uniprot id: U3BGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:MOGS
gene id: 9483:MOGS
uniprot id: F7E1L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9483:CASP2
gene id: 9483:CASP2
uniprot id: F7I2T9
names: Similarity
messages: Belongs to the peptidase C14A family.

9483:PIERCE2
gene id: 9483:PIERCE2
uniprot id: U3CVN2
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9483:IDI1
gene id: 9483:IDI1
uniprot id: U3BH55
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9483:LOC100392213
gene id: 9483:LOC100392213
uniprot id: A0A5F4W2J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9483:KIT
gene id: 9483:KIT
uniprot id: Q76II0
uniprot id: U3CN62
uniprot id: U3EUB3
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3CD. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).
messages: Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.
messages: Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Activity is down-regulated by PRKCA-mediated phosphorylation on serine residues (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).
messages: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation.

9483:EPHX1
gene id: 9483:EPHX1
uniprot id: F7IDL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9483:PTPN14
gene id: 9483:PTPN14
uniprot id: A0A5F4VSV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9483:TMTC3
gene id: 9483:TMTC3
uniprot id: U3EIN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9483:ZNF18
gene id: 9483:ZNF18
uniprot id: A0A2R8MCE1
uniprot id: F7HMB1
uniprot id: U3CC84
names: Subcellular Location Annotation
messages: Nucleus

9483:IK
gene id: 9483:IK
uniprot id: U3F464
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9483:STK10
gene id: 9483:STK10
uniprot id: F7HI69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane

9483:SPACA5
gene id: 9483:SPACA5
uniprot id: F7ALE5
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9483:KAT8
gene id: 9483:KAT8
uniprot id: F7HL51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9483:ATP5PF
gene id: 9483:ATP5PF
uniprot id: A0A2R8PKJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9483:SMAD1
gene id: 9483:SMAD1
uniprot id: U3D284
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9483:SFTPC
gene id: 9483:SFTPC
uniprot id: U3EVB1
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: surface film

9483:TBPL1
gene id: 9483:TBPL1
uniprot id: U3DHA7
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9483:SPAG7
gene id: 9483:SPAG7
uniprot id: F7I1A9
names: Subcellular Location Annotation
messages: Nucleus

9483:TMEM9
gene id: 9483:TMEM9
uniprot id: A0A8I3WNP0
names: Similarity
messages: Belongs to the TMEM9 family.

9483:OPRD1
gene id: 9483:OPRD1
uniprot id: F7IJ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TRMT112
gene id: 9483:TRMT112
uniprot id: F6Q6G2
names: Similarity
messages: Belongs to the TRM112 family.

9483:CA4
gene id: 9483:CA4
uniprot id: U3DPM7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9483:SGCG
gene id: 9483:SGCG
uniprot id: F7HWH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9483:ATG13
gene id: 9483:ATG13
uniprot id: F6YCQ9
uniprot id: U3CX99
uniprot id: U3DRN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9483:ATP5MC3
gene id: 9483:ATP5MC3
uniprot id: F7HAG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9483:CCT3
gene id: 9483:CCT3
uniprot id: F7HMY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9483:EIF4H
gene id: 9483:EIF4H
uniprot id: U3BSU7
names: Function
names: Subcellular Location Annotation
messages: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
messages: perinuclear region

9483:UBE2D2
gene id: 9483:UBE2D2
uniprot id: U3DVQ8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:LOC100415625
gene id: 9483:LOC100415625
uniprot id: A0A5F4WEM7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9483:FAM13C
gene id: 9483:FAM13C
uniprot id: U3DM92
names: Similarity
messages: Belongs to the FAM13 family.

9483:ADGRA3
gene id: 9483:ADGRA3
uniprot id: U3E886
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9483:CYP27B1
gene id: 9483:CYP27B1
uniprot id: F7HIZ6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:SF3B3
gene id: 9483:SF3B3
uniprot id: U3CQS7
names: Subcellular Location Annotation
messages: Nucleus

9483:PLK1
gene id: 9483:PLK1
uniprot id: F7I711
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

9483:HNRNPH1
gene id: 9483:HNRNPH1
uniprot id: A0A2R8MX49
uniprot id: F7ECV0
names: Subcellular Location Annotation
messages: nucleoplasm

9483:ZER1
gene id: 9483:ZER1
uniprot id: F6VZQ0
uniprot id: U3DDU9
names: Similarity
messages: Belongs to the zyg-11 family.

9483:LRRC42
gene id: 9483:LRRC42
uniprot id: F7IF62
uniprot id: F7IMX3
names: Similarity
messages: Belongs to the LRRC42 family.

9483:MED13
gene id: 9483:MED13
uniprot id: F7HQC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:ATP1B1
gene id: 9483:ATP1B1
uniprot id: F6THS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9483:PPIC
gene id: 9483:PPIC
uniprot id: F7IA22
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:RAP2A
gene id: 9483:RAP2A
uniprot id: F6UKW7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9483:POLD3
gene id: 9483:POLD3
uniprot id: F7AUU9
names: Subcellular Location Annotation
messages: Nucleus

9483:MC4R
gene id: 9483:MC4R
uniprot id: A8QXP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9483:ADGRF4
gene id: 9483:ADGRF4
uniprot id: F6TPG4
names: Subcellular Location Annotation
messages: Membrane

9483:DYNLT1
gene id: 9483:DYNLT1
uniprot id: F7F2V6
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9483:CELF6
gene id: 9483:CELF6
uniprot id: F6ZUM6
uniprot id: F7ILA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

9483:TMEM39A
gene id: 9483:TMEM39A
uniprot id: F6ZMT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9483:LOC100405643
gene id: 9483:LOC100405643
uniprot id: F6RXN0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9483:IFNW1
gene id: 9483:IFNW1
uniprot id: A0A7R8C4X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:C4BPB
gene id: 9483:C4BPB
uniprot id: F7BUT1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PSKH1
gene id: 9483:PSKH1
uniprot id: F7I5C9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:HCAR1
gene id: 9483:HCAR1
uniprot id: A0A5F4WJ68
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:TSPAN3
gene id: 9483:TSPAN3
uniprot id: U3BKC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:CYB5R4
gene id: 9483:CYB5R4
uniprot id: U3BKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9483:PKNOX2
gene id: 9483:PKNOX2
uniprot id: F6Z692
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9483:PPIP5K2
gene id: 9483:PPIP5K2
uniprot id: U3BTR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9483:NEDD8
gene id: 9483:NEDD8
uniprot id: F6S338
names: Similarity
messages: Belongs to the ubiquitin family.

9483:GCNT4
gene id: 9483:GCNT4
uniprot id: A0A8J8XJ19
uniprot id: F7IM95
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9483:GGT5
gene id: 9483:GGT5
uniprot id: A0A5K1U0E0
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

9483:XRN2
gene id: 9483:XRN2
uniprot id: F6UP03
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9483:SUCNR1
gene id: 9483:SUCNR1
uniprot id: A0A5F4W8U5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:CDV3
gene id: 9483:CDV3
uniprot id: U3B7B9
names: Similarity
messages: Belongs to the CDV3 family.

9483:TMED3
gene id: 9483:TMED3
uniprot id: U3C3B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9483:DYNLRB2
gene id: 9483:DYNLRB2
uniprot id: F6WT84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9483:MCRIP2
gene id: 9483:MCRIP2
uniprot id: F7BDC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9483:HINT2
gene id: 9483:HINT2
uniprot id: F7EQY7
names: Similarity
messages: Belongs to the HINT family.

9483:TPD52L1
gene id: 9483:TPD52L1
uniprot id: F7H5P4
uniprot id: F7HG13
uniprot id: U3DXF7
names: Similarity
messages: Belongs to the TPD52 family.

9483:AKR1B1
gene id: 9483:AKR1B1
uniprot id: F7HNF2
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9483:AATF
gene id: 9483:AATF
uniprot id: F6V458
names: Similarity
messages: Belongs to the AATF family.

9483:LRRC8A
gene id: 9483:LRRC8A
uniprot id: B0KWE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9483:NEO1
gene id: 9483:NEO1
uniprot id: A0A8I3WAW4
uniprot id: A0A8J8XLN2
uniprot id: A0A8J8Y231
uniprot id: A0A8J8Y270
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9483:OXT
gene id: 9483:OXT
uniprot id: G0ZNF4
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9483:NT5C2
gene id: 9483:NT5C2
uniprot id: U3BF11
uniprot id: U3FJG1
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9483:TRNT1
gene id: 9483:TRNT1
uniprot id: U3EM02
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9483:UPF1
gene id: 9483:UPF1
uniprot id: F7HDF7
uniprot id: U3D5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

9483:ATP23
gene id: 9483:ATP23
uniprot id: F7AHH1
names: Similarity
messages: Belongs to the peptidase M76 family.

9483:PRKAB1
gene id: 9483:PRKAB1
uniprot id: F7BMG6
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9483:CDC37L1
gene id: 9483:CDC37L1
uniprot id: U3BUQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9483:NIF3L1
gene id: 9483:NIF3L1
uniprot id: F6Z8K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

9483:RPS18
gene id: 9483:RPS18
uniprot id: F7I089
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.

9483:COQ5
gene id: 9483:COQ5
uniprot id: U3FTS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9483:CASK
gene id: 9483:CASK
uniprot id: A0A2R8MUH7
uniprot id: A0A2R8P5U8
uniprot id: A0A8J8YHG2
uniprot id: U3BRM7
uniprot id: U3CM89
uniprot id: U3DET2
uniprot id: U3EY01
names: Similarity
messages: Belongs to the MAGUK family.

9483:IL18R1
gene id: 9483:IL18R1
uniprot id: F7EMB0
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9483:ADGRG5
gene id: 9483:ADGRG5
uniprot id: A0A8I4A5T1
names: Subcellular Location Annotation
messages: Membrane

9483:PGM2L1
gene id: 9483:PGM2L1
uniprot id: F6UD41
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9483:ADAMTS5
gene id: 9483:ADAMTS5
uniprot id: F6VXD6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:UGCG
gene id: 9483:UGCG
uniprot id: U3ENT4
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9483:PSMA5
gene id: 9483:PSMA5
uniprot id: F7C3R5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:UBE2D3
gene id: 9483:UBE2D3
uniprot id: A0A2R8PG33
uniprot id: F6Z536
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:NUTF2
gene id: 9483:NUTF2
uniprot id: F7IRG6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9483:COPB2
gene id: 9483:COPB2
uniprot id: F6YR44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

9483:CXCL2
gene id: 9483:CXCL2
uniprot id: A0A5F4VXZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:GPD1
gene id: 9483:GPD1
uniprot id: U3D420
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9483:PTPN11
gene id: 9483:PTPN11
uniprot id: F7ICW6
uniprot id: U3C430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9483:GALNT17
gene id: 9483:GALNT17
uniprot id: F7FHV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:SNAPIN
gene id: 9483:SNAPIN
uniprot id: F6RYC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9483:LYVE1
gene id: 9483:LYVE1
uniprot id: A0A5F4W3K1
uniprot id: F7H6X6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:YJU2B
gene id: 9483:YJU2B
uniprot id: F6Z9F1
names: Similarity
messages: Belongs to the CWC16 family.

9483:RPA1
gene id: 9483:RPA1
uniprot id: A0A8I3VV06
uniprot id: U3DXL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

9483:VGLL1
gene id: 9483:VGLL1
uniprot id: F7F2W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9483:CSTA
gene id: 9483:CSTA
uniprot id: F7GIC1
names: Similarity
messages: Belongs to the cystatin family.

9483:SGTA
gene id: 9483:SGTA
uniprot id: U3ELV4
names: Similarity
messages: Belongs to the SGT family.

9483:GSG1L2
gene id: 9483:GSG1L2
uniprot id: F7IFZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9483:CYP20A1
gene id: 9483:CYP20A1
uniprot id: U3ELF2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:TOMM5
gene id: 9483:TOMM5
uniprot id: F6TDI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:TMEM86A
gene id: 9483:TMEM86A
uniprot id: U3FEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9483:TBC1D7
gene id: 9483:TBC1D7
uniprot id: A0A2R8M8P0
uniprot id: F6PP80
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9483:CAMLG
gene id: 9483:CAMLG
uniprot id: F7HWS9
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9483:ASH2L
gene id: 9483:ASH2L
uniprot id: F6RGV9
uniprot id: U3E6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:AGAP2
gene id: 9483:AGAP2
uniprot id: F6PYY5
uniprot id: F6PZU7
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9483:SLC26A3
gene id: 9483:SLC26A3
uniprot id: F7BSM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane

9483:SCP2
gene id: 9483:SCP2
uniprot id: F7EZA5
uniprot id: U3ATI5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion

9483:NEFL
gene id: 9483:NEFL
uniprot id: F6UX82
names: Similarity
messages: Belongs to the intermediate filament family.

9483:MPV17L2
gene id: 9483:MPV17L2
uniprot id: F6X2A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9483:SIKE1
gene id: 9483:SIKE1
uniprot id: U3EVM9
names: Similarity
messages: Belongs to the SIKE family.

9483:NPY2R
gene id: 9483:NPY2R
uniprot id: F7HQL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ST6GAL1
gene id: 9483:ST6GAL1
uniprot id: F7I274
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:GAD2
gene id: 9483:GAD2
uniprot id: F7I4W5
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9483:WNT2B
gene id: 9483:WNT2B
uniprot id: A0A2R8MND7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:AP3S2
gene id: 9483:AP3S2
uniprot id: U3FIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9483:SMARCA5
gene id: 9483:SMARCA5
uniprot id: U3FB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9483:RAD23A
gene id: 9483:RAD23A
uniprot id: F7ISE1
uniprot id: F7ISF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9483:WNT3A
gene id: 9483:WNT3A
uniprot id: A0A5F4W3S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:OGFRL1
gene id: 9483:OGFRL1
uniprot id: F7HBA9
uniprot id: U3EEX7
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

9483:ATP6V1E2
gene id: 9483:ATP6V1E2
uniprot id: A0A2R8MGJ7
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9483:PPP1R14C
gene id: 9483:PPP1R14C
uniprot id: F6S3F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Inhibitor of PPP1CA.
messages: Membrane

9483:RC3H2
gene id: 9483:RC3H2
uniprot id: F7BIJ6
names: Subcellular Location Annotation
messages: P-body

9483:PAGE4
gene id: 9483:PAGE4
uniprot id: U3CV35
names: Similarity
messages: Belongs to the GAGE family.

9483:SYNE3
gene id: 9483:SYNE3
uniprot id: U3C818
names: Similarity
messages: Belongs to the nesprin family.

9483:CLDN1
gene id: 9483:CLDN1
uniprot id: U3BKB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:AMOTL2
gene id: 9483:AMOTL2
uniprot id: U3E3V5
names: Similarity
messages: Belongs to the angiomotin family.

9483:CEBPE
gene id: 9483:CEBPE
uniprot id: A0A2R8PMY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9483:GPX4
gene id: 9483:GPX4
uniprot id: Q32QL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutathione peroxidase family.
messages: Cytoplasm
messages: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).
messages: Expressed in testis. Also expressed in liver, lung, kidney and spinal cord.
messages: Mitochondrion
messages: Monomer. Has a tendency to form higher mass oligomers.

9483:KDSR
gene id: 9483:KDSR
uniprot id: A0A5F4W9Q5
uniprot id: F7H8H1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:TIMM10
gene id: 9483:TIMM10
uniprot id: F6XGD1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9483:SLC7A6
gene id: 9483:SLC7A6
uniprot id: U3FHB9
names: Subcellular Location Annotation
messages: Membrane

9483:GABRB1
gene id: 9483:GABRB1
uniprot id: U3DHM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:LOC100385283
gene id: 9483:LOC100385283
uniprot id: A0A8I3W1K5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:RDH11
gene id: 9483:RDH11
uniprot id: U3D6T3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:RPL34
gene id: 9483:RPL34
uniprot id: F7HLG2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9483:OSGEP
gene id: 9483:OSGEP
uniprot id: F7IEF6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

9483:LBX2
gene id: 9483:LBX2
uniprot id: A0A2R8M7T5
names: Subcellular Location Annotation
messages: Nucleus

9483:PPP1R14D
gene id: 9483:PPP1R14D
uniprot id: F7ISZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9483:CBX8
gene id: 9483:CBX8
uniprot id: F7F3P9
names: Subcellular Location Annotation
messages: Nucleus

9483:ITGB8
gene id: 9483:ITGB8
uniprot id: A0A8I3WN73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9483:LMBR1
gene id: 9483:LMBR1
uniprot id: A0A2R8P8A6
uniprot id: U3ECC1
names: Similarity
messages: Belongs to the LIMR family.

9483:MEF2C
gene id: 9483:MEF2C
uniprot id: A0A2R8MTX5
uniprot id: F6YQS7
uniprot id: F7E2K3
uniprot id: U3EHQ5
names: Subcellular Location Annotation
messages: Nucleus

9483:IGF2BP1
gene id: 9483:IGF2BP1
uniprot id: F6X5X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9483:UTP6
gene id: 9483:UTP6
uniprot id: A0A8I3WP38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

9483:RAB32
gene id: 9483:RAB32
uniprot id: F6YNF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9483:EIF2S2
gene id: 9483:EIF2S2
uniprot id: F6SFK4
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9483:S100B
gene id: 9483:S100B
uniprot id: F7HBN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9483:MED7
gene id: 9483:MED7
uniprot id: F7FJ65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9483:EFNA5
gene id: 9483:EFNA5
uniprot id: A0A2R8MDR2
uniprot id: U3CAF9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:TMPRSS13
gene id: 9483:TMPRSS13
uniprot id: F7H942
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:EFNB2
gene id: 9483:EFNB2
uniprot id: F7ENK8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:GIPR
gene id: 9483:GIPR
uniprot id: F6Y4K4
names: Subcellular Location Annotation
messages: Membrane

9483:GADD45A
gene id: 9483:GADD45A
uniprot id: A0A8I3WE50
uniprot id: F7E1K0
names: Similarity
messages: Belongs to the GADD45 family.

9483:TSPAN12
gene id: 9483:TSPAN12
uniprot id: U3F063
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:MRAP
gene id: 9483:MRAP
uniprot id: A0A8I3WIB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:DCTN1
gene id: 9483:DCTN1
uniprot id: A0A5F4W4E2
uniprot id: F7H677
uniprot id: U3B3Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: Cytoplasm
messages: cell cortex
messages: cytoskeleton

9483:AZIN1
gene id: 9483:AZIN1
uniprot id: F6RSV2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9483:NR2C2
gene id: 9483:NR2C2
uniprot id: A0A2R8NC69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9483:RNF4
gene id: 9483:RNF4
uniprot id: F7HV40
names: Subcellular Location Annotation
messages: Nucleus

9483:CRELD1
gene id: 9483:CRELD1
uniprot id: U3CMD9
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOC100897022
gene id: 9483:LOC100897022
uniprot id: U3FCQ0
names: Similarity
messages: Belongs to the pro/parathymosin family.

9483:SELENBP1
gene id: 9483:SELENBP1
uniprot id: F6VWU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9483:RBM47
gene id: 9483:RBM47
uniprot id: U3BG53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Cytoplasm
messages: Nucleus

9483:DNAAF4
gene id: 9483:DNAAF4
uniprot id: F6WBM2
uniprot id: U3E2B1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Dynein axonemal particle
messages: neuron projection

9483:PPIL2
gene id: 9483:PPIL2
uniprot id: U3FA41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9483:NDUFAB1
gene id: 9483:NDUFAB1
uniprot id: U3AQ14
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9483:OVOL1
gene id: 9483:OVOL1
uniprot id: F7F0J6
names: Subcellular Location Annotation
messages: Nucleus

9483:APOA1
gene id: 9483:APOA1
uniprot id: B0KWR1
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9483:SMC4
gene id: 9483:SMC4
uniprot id: A0A8I3ZZA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Chromosome
messages: Nucleus

9483:DDX47
gene id: 9483:DDX47
uniprot id: U3D605
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9483:RBBP4
gene id: 9483:RBBP4
uniprot id: U3BF00
names: Subcellular Location Annotation
messages: Nucleus

9483:NTMT1
gene id: 9483:NTMT1
uniprot id: A0A8I4A1R7
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9483:HPSE
gene id: 9483:HPSE
uniprot id: A0A2R8MKT5
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9483:GOLM1
gene id: 9483:GOLM1
uniprot id: U3CE44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9483:CSRNP3
gene id: 9483:CSRNP3
uniprot id: F6PRX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9483:ALDH9A1
gene id: 9483:ALDH9A1
uniprot id: U3CQG4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:L3HYPDH
gene id: 9483:L3HYPDH
uniprot id: F7IKN7
names: Similarity
messages: Belongs to the proline racemase family.

9483:KIF11
gene id: 9483:KIF11
uniprot id: A0A8I3WQI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle pole

9483:CNDP2
gene id: 9483:CNDP2
uniprot id: F7HVP6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9483:TLCD3B
gene id: 9483:TLCD3B
uniprot id: U3ERZ3
names: Subcellular Location Annotation
messages: Membrane

9483:RAMP1
gene id: 9483:RAMP1
uniprot id: F6PYH1
names: Similarity
messages: Belongs to the RAMP family.

9483:DYDC1
gene id: 9483:DYDC1
uniprot id: F7HBD3
names: Similarity
messages: Belongs to the dpy-30 family.

9483:CDH8
gene id: 9483:CDH8
uniprot id: U3E3K3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:UBE2G1
gene id: 9483:UBE2G1
uniprot id: F6RX83
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:C1H9orf78
gene id: 9483:C1H9orf78
uniprot id: F7CRF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLS1 family.
messages: Nucleus

9483:CXCL8
gene id: 9483:CXCL8
uniprot id: A0A8I4A1B7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

9483:ING4
gene id: 9483:ING4
uniprot id: F7I4B8
uniprot id: U3BM82
uniprot id: U3CQ34
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9483:POLR3F
gene id: 9483:POLR3F
uniprot id: A0A8I3XE62
uniprot id: F7GCJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9483:POPDC2
gene id: 9483:POPDC2
uniprot id: A0A2R8MF15
uniprot id: U3FG09
names: Similarity
messages: Belongs to the popeye family.

9483:PTMA
gene id: 9483:PTMA
uniprot id: A0A8I3WRE3
uniprot id: U3FCQ0
names: Similarity
messages: Belongs to the pro/parathymosin family.

9483:TMX2
gene id: 9483:TMX2
uniprot id: F7H9V7
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9483:PFN4
gene id: 9483:PFN4
uniprot id: F7IBR9
names: Similarity
messages: Belongs to the profilin family.

9483:RPL8
gene id: 9483:RPL8
uniprot id: F7GNR1
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9483:LOC100390342
gene id: 9483:LOC100390342
uniprot id: A0A8I3X0Z4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:BMPR1A
gene id: 9483:BMPR1A
uniprot id: A0A5K1U8C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9483:UBE3D
gene id: 9483:UBE3D
uniprot id: U3FPY6
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

9483:PRDM1
gene id: 9483:PRDM1
uniprot id: A0A2R8MN23
uniprot id: A0A5F4WJ23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9483:DAPK3
gene id: 9483:DAPK3
uniprot id: U3EE09
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:TRIM36
gene id: 9483:TRIM36
uniprot id: F7GT52
names: Subcellular Location Annotation
names: Subunit
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: cytoskeleton

9483:VAX1
gene id: 9483:VAX1
uniprot id: A0A2R8N321
names: Subcellular Location Annotation
messages: Nucleus

9483:BECN1
gene id: 9483:BECN1
uniprot id: A0A8I3WGG4
uniprot id: U3BN92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

9483:WDR83OS
gene id: 9483:WDR83OS
uniprot id: F7EUK6
names: Similarity
messages: Belongs to the Asterix family.

9483:UTP18
gene id: 9483:UTP18
uniprot id: A0A8J8XTK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

9483:EMC3
gene id: 9483:EMC3
uniprot id: F7I2L0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9483:MMUT
gene id: 9483:MMUT
uniprot id: A0A2R8MCH4
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

9483:TMTC4
gene id: 9483:TMTC4
uniprot id: A0A8I3VYA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9483:IL7R
gene id: 9483:IL7R
uniprot id: A5HJM1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.

9483:TMEM9B
gene id: 9483:TMEM9B
uniprot id: F6RAC2
names: Similarity
messages: Belongs to the TMEM9 family.

9483:KIZ
gene id: 9483:KIZ
uniprot id: U3B928
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

9483:TIGD1
gene id: 9483:TIGD1
uniprot id: F6SUC8
names: Subcellular Location Annotation
messages: Nucleus

9483:TAF1B
gene id: 9483:TAF1B
uniprot id: F7D4T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

9483:PCMT1
gene id: 9483:PCMT1
uniprot id: A0A8J8XFP4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9483:GPR37L1
gene id: 9483:GPR37L1
uniprot id: F7D1B0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:WDR48
gene id: 9483:WDR48
uniprot id: F7GA04
uniprot id: F7GRJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Late endosome

9483:MRPS18A
gene id: 9483:MRPS18A
uniprot id: U3CCR0
names: Subcellular Location Annotation
messages: Mitochondrion

9483:PDLIM3
gene id: 9483:PDLIM3
uniprot id: A0A8I3WPM0
uniprot id: F7IKP8
names: Subcellular Location Annotation
messages: Z line

9483:COA5
gene id: 9483:COA5
uniprot id: A0A8I4A0R0
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9483:LMNB1
gene id: 9483:LMNB1
uniprot id: F7EH81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9483:SSBP2
gene id: 9483:SSBP2
uniprot id: A0A8I3W1R4
uniprot id: F7FQL7
uniprot id: U3DVE1
uniprot id: U3EGN9
names: Subcellular Location Annotation
messages: Nucleus

9483:HSBP1L1
gene id: 9483:HSBP1L1
uniprot id: F7H0N8
names: Similarity
messages: Belongs to the HSBP1 family.

9483:STIM2
gene id: 9483:STIM2
uniprot id: A0A5F4WLF5
uniprot id: F7EAG6
uniprot id: F7EAI3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:TADA1
gene id: 9483:TADA1
uniprot id: U3EKL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9483:TBC1D31
gene id: 9483:TBC1D31
uniprot id: A0A5K1UFN6
uniprot id: F7BFT0
names: Function
names: Subcellular Location Annotation
messages: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
messages: centriolar satellite
messages: cilium basal body

9483:ALG5
gene id: 9483:ALG5
uniprot id: A0A8I3WIV8
uniprot id: A0A8I3WLK3
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9483:STRIP1
gene id: 9483:STRIP1
uniprot id: F7FY24
names: Similarity
messages: Belongs to the STRIP family.

9483:UGT8
gene id: 9483:UGT8
uniprot id: F7F597
uniprot id: U3CT46
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9483:VIP
gene id: 9483:VIP
uniprot id: F7ID94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9483:PDE6D
gene id: 9483:PDE6D
uniprot id: A0A2R8MZS4
uniprot id: U3F978
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9483:SPEM2
gene id: 9483:SPEM2
uniprot id: F6VSK4
names: Subcellular Location Annotation
messages: Membrane

9483:ACTRT2
gene id: 9483:ACTRT2
uniprot id: A0A2R8P9Q1
names: Similarity
messages: Belongs to the actin family.

9483:CDC45
gene id: 9483:CDC45
uniprot id: F7IIN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9483:LOC100398394
gene id: 9483:LOC100398394
uniprot id: F6Q3N9
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9483:BMP10
gene id: 9483:BMP10
uniprot id: F7IKG6
names: Similarity
messages: Belongs to the TGF-beta family.

9483:SLC13A3
gene id: 9483:SLC13A3
uniprot id: U3F1K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9483:RACK1
gene id: 9483:RACK1
uniprot id: F7ICV3
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

9483:CDCA8
gene id: 9483:CDCA8
uniprot id: F7H9W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9483:GNB5
gene id: 9483:GNB5
uniprot id: U3D678
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9483:LOC100401791
gene id: 9483:LOC100401791
uniprot id: A0A8I3VXS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:HIGD1A
gene id: 9483:HIGD1A
uniprot id: A0A8I3WK81
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9483:LOC100401281
gene id: 9483:LOC100401281
uniprot id: F7A3K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9483:GJB5
gene id: 9483:GJB5
uniprot id: F7I2A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:GPHN
gene id: 9483:GPHN
uniprot id: A0A8I3WEH8
uniprot id: A0A8I3WIT4
uniprot id: U3CGY7
uniprot id: U3FKH4
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9483:MAN1A2
gene id: 9483:MAN1A2
uniprot id: U3FXH5
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9483:PLPBP
gene id: 9483:PLPBP
uniprot id: F7I3A2
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9483:PLEKHA8
gene id: 9483:PLEKHA8
uniprot id: A0A8I4A4K9
uniprot id: U3DPZ8
names: Subcellular Location Annotation
messages: trans-Golgi network membrane

9483:ASPN
gene id: 9483:ASPN
uniprot id: F7ILC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9483:GPR158
gene id: 9483:GPR158
uniprot id: F7HR18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:CELSR2
gene id: 9483:CELSR2
uniprot id: U3FXU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

9483:LOC100410514
gene id: 9483:LOC100410514
uniprot id: A0A8I3W3G2
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9483:LOC100407794
gene id: 9483:LOC100407794
uniprot id: A0A2R8NDJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9483:TRAPPC2L
gene id: 9483:TRAPPC2L
uniprot id: U3FMB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9483:TEF
gene id: 9483:TEF
uniprot id: F7HNV2
uniprot id: F7I370
uniprot id: U3FVL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9483:ODC1
gene id: 9483:ODC1
uniprot id: F7GMF7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9483:SND1
gene id: 9483:SND1
uniprot id: U3BQS3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9483:SLC6A14
gene id: 9483:SLC6A14
uniprot id: F7BP63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9483:PHYKPL
gene id: 9483:PHYKPL
uniprot id: U3BHS3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9483:USO1
gene id: 9483:USO1
uniprot id: A0A2R8MUA2
uniprot id: U3ETI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

9483:EML4
gene id: 9483:EML4
uniprot id: F7E9Y2
uniprot id: F7GPN0
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9483:LOC100406157
gene id: 9483:LOC100406157
uniprot id: U3FTR3
names: Subcellular Location Annotation
messages: Membrane

9483:EVX1
gene id: 9483:EVX1
uniprot id: B0VXL0
names: Subcellular Location Annotation
messages: Nucleus

9483:PRKCD
gene id: 9483:PRKCD
uniprot id: F6ZHC0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

9483:PPFIA1
gene id: 9483:PPFIA1
uniprot id: A0A8I3X0S7
uniprot id: U3BNY6
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9483:DOK6
gene id: 9483:DOK6
uniprot id: F7ILS8
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9483:PSMA3
gene id: 9483:PSMA3
uniprot id: F7IS34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:C14H2orf49
gene id: 9483:C14H2orf49
uniprot id: F7IST7
uniprot id: U3D1E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9483:MCU
gene id: 9483:MCU
uniprot id: F6WI22
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9483:ACVR1C
gene id: 9483:ACVR1C
uniprot id: F7H6A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9483:RRAGD
gene id: 9483:RRAGD
uniprot id: F6VSE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9483:SOX11
gene id: 9483:SOX11
uniprot id: A0A2R8MWJ4
names: Subcellular Location Annotation
messages: Nucleus

9483:FAM241B
gene id: 9483:FAM241B
uniprot id: F6XHS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9483:OR5D18
gene id: 9483:OR5D18
uniprot id: A0A2R8MSW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:YWHAG
gene id: 9483:YWHAG
uniprot id: F7DNK1
names: Similarity
messages: Belongs to the 14-3-3 family.

9483:C9H12orf57
gene id: 9483:C9H12orf57
uniprot id: U3BEU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

9483:DEFB126
gene id: 9483:DEFB126
uniprot id: A0A8I3WMU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:IPO7
gene id: 9483:IPO7
uniprot id: F6PKJ8
names: Subcellular Location Annotation
messages: Cytoplasm

9483:STAMBP
gene id: 9483:STAMBP
uniprot id: U3D897
names: Similarity
messages: Belongs to the peptidase M67C family.

9483:NT5DC1
gene id: 9483:NT5DC1
uniprot id: A0A2R8N7M8
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

9483:DHX15
gene id: 9483:DHX15
uniprot id: F7HGM8
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9483:THNSL1
gene id: 9483:THNSL1
uniprot id: F7HKB5
names: Similarity
messages: Belongs to the threonine synthase family.

9483:ATP5MC1
gene id: 9483:ATP5MC1
uniprot id: A0A5F4VT63
uniprot id: A0A8I3VYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9483:ARHGEF3
gene id: 9483:ARHGEF3
uniprot id: A0A5K1VRD5
uniprot id: F7FYU0
uniprot id: F7GL31
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9483:SAP130
gene id: 9483:SAP130
uniprot id: A0A8I3WIR2
uniprot id: F7E211
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9483:RDH14
gene id: 9483:RDH14
uniprot id: F7AE01
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:EXO5
gene id: 9483:EXO5
uniprot id: F6TP17
names: Similarity
messages: Belongs to the EXO5 family.

9483:CLCN6
gene id: 9483:CLCN6
uniprot id: F6YJI7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SMIM8
gene id: 9483:SMIM8
uniprot id: A0A8I3X399
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9483:STEAP2
gene id: 9483:STEAP2
uniprot id: B0VXE5
uniprot id: U3D7S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9483:DENND6A
gene id: 9483:DENND6A
uniprot id: U3BSL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

9483:GNAI2
gene id: 9483:GNAI2
uniprot id: F6ZZK3
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9483:RDH10
gene id: 9483:RDH10
uniprot id: U3DMT3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:TMEM263
gene id: 9483:TMEM263
uniprot id: F7GTZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9483:IL36RN
gene id: 9483:IL36RN
uniprot id: F6VYZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9483:LOC100407433
gene id: 9483:LOC100407433
uniprot id: F6RAS1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:TCTN1
gene id: 9483:TCTN1
uniprot id: U3F6Q5
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9483:EVX2
gene id: 9483:EVX2
uniprot id: A0A8I3W8Y3
names: Subcellular Location Annotation
messages: Nucleus

9483:GJB1
gene id: 9483:GJB1
uniprot id: F6RE67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:STK3
gene id: 9483:STK3
uniprot id: U3DWY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9483:IGF1
gene id: 9483:IGF1
uniprot id: A0A2R8PMZ8
uniprot id: U3D2G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9483:ABCA4
gene id: 9483:ABCA4
uniprot id: F6R1N0
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

9483:LOC100392652
gene id: 9483:LOC100392652
uniprot id: F7FFB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SLC28A3
gene id: 9483:SLC28A3
uniprot id: F6TSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9483:TNFAIP1
gene id: 9483:TNFAIP1
uniprot id: F7I5U0
names: Similarity
messages: Belongs to the BACURD family.

9483:PALS2
gene id: 9483:PALS2
uniprot id: F6ZVZ4
uniprot id: U3DTF2
names: Similarity
messages: Belongs to the MAGUK family.

9483:LOC100403489
gene id: 9483:LOC100403489
uniprot id: A0A8I3XA83
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:LOC103787206
gene id: 9483:LOC103787206
uniprot id: U3DJ48
names: Similarity
messages: Belongs to the pleiotrophin family.

9483:PIGP
gene id: 9483:PIGP
uniprot id: F6WQP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

9483:SLC27A2
gene id: 9483:SLC27A2
uniprot id: F7ISY6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:TUBD1
gene id: 9483:TUBD1
uniprot id: U3CA49
uniprot id: U3FMD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9483:ALKBH6
gene id: 9483:ALKBH6
uniprot id: U3FY57
names: Similarity
messages: Belongs to the alkB family.

9483:FAM241A
gene id: 9483:FAM241A
uniprot id: F7H5J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9483:OSBPL2
gene id: 9483:OSBPL2
uniprot id: F7IE45
names: Similarity
messages: Belongs to the OSBP family.

9483:SLC25A37
gene id: 9483:SLC25A37
uniprot id: U3C4C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:LOC100409675
gene id: 9483:LOC100409675
uniprot id: A0A8I4A3H8
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9483:MS4A1
gene id: 9483:MS4A1
uniprot id: Q3LRP2
names: Similarity
messages: Belongs to the MS4A family.

9483:ITGA8
gene id: 9483:ITGA8
uniprot id: F7ALM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9483:CWC25
gene id: 9483:CWC25
uniprot id: U3EAP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9483:GAR1
gene id: 9483:GAR1
uniprot id: U3B6I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9483:CDC42BPA
gene id: 9483:CDC42BPA
uniprot id: U3EZV2
uniprot id: U3F4D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9483:STX7
gene id: 9483:STX7
uniprot id: B0KWA3
names: Similarity
messages: Belongs to the syntaxin family.

9483:CERS6
gene id: 9483:CERS6
uniprot id: F7I442
uniprot id: F7I6G2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9483:ETFDH
gene id: 9483:ETFDH
uniprot id: A0A5F4WDT9
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9483:VOPP1
gene id: 9483:VOPP1
uniprot id: U3BC45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Endosome membrane
messages: Interacts with WWOX (via WW domain).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9483:CTPS2
gene id: 9483:CTPS2
uniprot id: A0A5F4W4V1
uniprot id: A0A5F4WL23
uniprot id: F7CKK2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9483:LSM2
gene id: 9483:LSM2
uniprot id: F7C2X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9483:TFCP2
gene id: 9483:TFCP2
uniprot id: U3EZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9483:ZKSCAN1
gene id: 9483:ZKSCAN1
uniprot id: F6W5I1
names: Subcellular Location Annotation
messages: Nucleus

9483:GALT
gene id: 9483:GALT
uniprot id: F6VPS6
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9483:ZDHHC22
gene id: 9483:ZDHHC22
uniprot id: F6Y2X5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:NAGK
gene id: 9483:NAGK
uniprot id: A0A8I3WTA6
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9483:MARK4
gene id: 9483:MARK4
uniprot id: U3BWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9483:TNFAIP3
gene id: 9483:TNFAIP3
uniprot id: F7I413
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:SKAP2
gene id: 9483:SKAP2
uniprot id: A0A8I3WDR4
names: Similarity
messages: Belongs to the SKAP family.

9483:TWF1
gene id: 9483:TWF1
uniprot id: A0A8J8XM35
uniprot id: A0A8J8XXN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9483:TNS3
gene id: 9483:TNS3
uniprot id: U3C992
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9483:GINS2
gene id: 9483:GINS2
uniprot id: F7IEQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9483:THOC7
gene id: 9483:THOC7
uniprot id: A0A5F4W1V2
uniprot id: U3EI93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

9483:SLC9A1
gene id: 9483:SLC9A1
uniprot id: F6ZMV1
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9483:EIF4EBP2
gene id: 9483:EIF4EBP2
uniprot id: F7I0B2
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9483:LOC100399796
gene id: 9483:LOC100399796
uniprot id: A0A2R8MMI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9483:UBE2F
gene id: 9483:UBE2F
uniprot id: F7E5F0
uniprot id: F7IDH7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:LOC100404354
gene id: 9483:LOC100404354
uniprot id: A0A8I3WBI1
uniprot id: F7INF4
names: Similarity
messages: Belongs to the multicopper oxidase family.

9483:MYSM1
gene id: 9483:MYSM1
uniprot id: U3D192
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.
messages: Nucleus

9483:SNRPD3
gene id: 9483:SNRPD3
uniprot id: F7HY39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9483:ANAPC10
gene id: 9483:ANAPC10
uniprot id: F6YKH3
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9483:AQR
gene id: 9483:AQR
uniprot id: U3EN21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWF11 family.
messages: Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.
messages: Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
messages: Nucleus

9483:EXOC8
gene id: 9483:EXOC8
uniprot id: U3AW65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9483:FBXO46
gene id: 9483:FBXO46
uniprot id: U3FLG3
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9483:RNPC3
gene id: 9483:RNPC3
uniprot id: F7CKT0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

9483:CHAF1A
gene id: 9483:CHAF1A
uniprot id: U3BQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHAF1A family.
messages: Nucleus

9483:ZSCAN31
gene id: 9483:ZSCAN31
uniprot id: F7HWM1
names: Subcellular Location Annotation
messages: Nucleus

9483:PDE7B
gene id: 9483:PDE7B
uniprot id: A0A2R8MIN9
uniprot id: F7DVY7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:CNR1
gene id: 9483:CNR1
uniprot id: F7CF55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.
messages: Interacts (via C-terminus) with CNRIP1.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

9483:APOC1
gene id: 9483:APOC1
uniprot id: A0A8I3WXK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C1 family.
messages: Secreted

9483:SLC7A8
gene id: 9483:SLC7A8
uniprot id: A0A8I3W8P1
names: Subcellular Location Annotation
messages: Membrane

9483:SGSH
gene id: 9483:SGSH
uniprot id: F7DJR5
names: Similarity
messages: Belongs to the sulfatase family.

9483:FGD6
gene id: 9483:FGD6
uniprot id: U3DL37
names: Subcellular Location Annotation
messages: cytoskeleton

9483:TUBGCP4
gene id: 9483:TUBGCP4
uniprot id: A0A8I4A2B3
uniprot id: F7HYF3
uniprot id: U3BHN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9483:STRADB
gene id: 9483:STRADB
uniprot id: A0A2R8ME70
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9483:PARP11
gene id: 9483:PARP11
uniprot id: F7IBI0
uniprot id: U3C7G5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:GSK3B
gene id: 9483:GSK3B
uniprot id: A0A2R8M2M3
uniprot id: A0A2R8M2U0
uniprot id: F6V0J0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9483:RDH8
gene id: 9483:RDH8
uniprot id: F7IKQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

9483:CSNK2A2
gene id: 9483:CSNK2A2
uniprot id: F6R0E2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:HMOX1
gene id: 9483:HMOX1
uniprot id: U3B7F4
names: Similarity
messages: Belongs to the heme oxygenase family.

9483:LOC100406879
gene id: 9483:LOC100406879
uniprot id: A0A8I4A3R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:YPEL5
gene id: 9483:YPEL5
uniprot id: F7HRG9
names: Similarity
messages: Belongs to the yippee family.

9483:TRAF6
gene id: 9483:TRAF6
uniprot id: F7ES31
uniprot id: U3DER5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9483:P2RY13
gene id: 9483:P2RY13
uniprot id: F6XPZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TBC1D23
gene id: 9483:TBC1D23
uniprot id: F7B3B4
uniprot id: U3BR58
names: Subcellular Location Annotation
messages: trans-Golgi network

9483:UBE2D1
gene id: 9483:UBE2D1
uniprot id: A0A2R8MUS0
uniprot id: F6QMS1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:RGS14
gene id: 9483:RGS14
uniprot id: U3BVC0
names: Subcellular Location Annotation
messages: dendrite

9483:MAP3K9
gene id: 9483:MAP3K9
uniprot id: F7GPM0
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9483:DNAAF6
gene id: 9483:DNAAF6
uniprot id: F7GS79
names: Similarity
messages: Belongs to the PIH1 family.

9483:COPG2
gene id: 9483:COPG2
uniprot id: U3CBT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9483:CC2D1B
gene id: 9483:CC2D1B
uniprot id: U3BD00
uniprot id: U3D670
names: Similarity
messages: Belongs to the CC2D1 family.

9483:CACFD1
gene id: 9483:CACFD1
uniprot id: F7H4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

9483:MTHFD1
gene id: 9483:MTHFD1
uniprot id: U3FKL3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9483:NEK8
gene id: 9483:NEK8
uniprot id: A0A8I3WJ52
uniprot id: F7D996
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9483:DEFB108B
gene id: 9483:DEFB108B
uniprot id: F6RM81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:CPNE9
gene id: 9483:CPNE9
uniprot id: F7I7P4
names: Similarity
messages: Belongs to the copine family.

9483:PJVK
gene id: 9483:PJVK
uniprot id: F7IH02
names: Similarity
messages: Belongs to the gasdermin family.

9483:ISL2
gene id: 9483:ISL2
uniprot id: F7DL07
names: Subcellular Location Annotation
messages: Nucleus

9483:CFB
gene id: 9483:CFB
uniprot id: F7AP80
uniprot id: U3FAF5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:EMC6
gene id: 9483:EMC6
uniprot id: F6X896
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:SMG1
gene id: 9483:SMG1
uniprot id: F6S837
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9483:CCDC172
gene id: 9483:CCDC172
uniprot id: F7GTK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

9483:RAB39A
gene id: 9483:RAB39A
uniprot id: F7G8P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9483:SLC2A2
gene id: 9483:SLC2A2
uniprot id: F7AN96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9483:CKS1B
gene id: 9483:CKS1B
uniprot id: F7IM94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9483:FSCN1
gene id: 9483:FSCN1
uniprot id: U3EU72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9483:FAM161A
gene id: 9483:FAM161A
uniprot id: A0A8J8Y4H3
uniprot id: F6YP42
names: Similarity
messages: Belongs to the FAM161 family.

9483:ASZ1
gene id: 9483:ASZ1
uniprot id: Q2QLG0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

9483:RPS13
gene id: 9483:RPS13
uniprot id: F7IH12
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9483:DKK4
gene id: 9483:DKK4
uniprot id: F7IIK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9483:CASD1
gene id: 9483:CASD1
uniprot id: A0A8I4A1B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

9483:ESX1
gene id: 9483:ESX1
uniprot id: F7GUU9
names: Subcellular Location Annotation
messages: Nucleus

9483:TMEM237
gene id: 9483:TMEM237
uniprot id: U3DWS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9483:SLC25A20
gene id: 9483:SLC25A20
uniprot id: F6ZL48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:PSMC3
gene id: 9483:PSMC3
uniprot id: U3E6L1
names: Similarity
messages: Belongs to the AAA ATPase family.

9483:TRIM21
gene id: 9483:TRIM21
uniprot id: F7ALH2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:PABPC1
gene id: 9483:PABPC1
uniprot id: F7I5L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9483:HP
gene id: 9483:HP
uniprot id: U3D531
names: Caution
names: Function
names: Similarity
names: Subunit
messages: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta chains; disulfide-linked (By similarity). The hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers (By similarity). Interacts with CD163 (By similarity). Interacts with ERGIC3.

9483:PON3
gene id: 9483:PON3
uniprot id: U3DKS0
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9483:SHROOM3
gene id: 9483:SHROOM3
uniprot id: A0A8I3WDK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9483:CDH24
gene id: 9483:CDH24
uniprot id: F7DFL0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:UPF2
gene id: 9483:UPF2
uniprot id: F7INJ8
names: Subcellular Location Annotation
messages: Cytoplasm

9483:REEP5
gene id: 9483:REEP5
uniprot id: U3FI78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9483:EPHA5
gene id: 9483:EPHA5
uniprot id: A0A5F4W3L2
uniprot id: F7ITC6
uniprot id: U3ENY5
uniprot id: U3EYB4
names: Subcellular Location Annotation
messages: Membrane

9483:SFXN4
gene id: 9483:SFXN4
uniprot id: F7H4D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9483:SEMA7A
gene id: 9483:SEMA7A
uniprot id: U3NLN1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CNTF
gene id: 9483:CNTF
uniprot id: U3EDL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9483:RRAD
gene id: 9483:RRAD
uniprot id: F6VQZ9
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9483:AUH
gene id: 9483:AUH
uniprot id: F7ISC3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9483:NUDT2
gene id: 9483:NUDT2
uniprot id: F7E8D9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9483:PPP2R5D
gene id: 9483:PPP2R5D
uniprot id: A0A2R8MHR3
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9483:CLRN2
gene id: 9483:CLRN2
uniprot id: F7IQE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9483:ECHDC1
gene id: 9483:ECHDC1
uniprot id: A0A2R8MQZ9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9483:XPO1
gene id: 9483:XPO1
uniprot id: A0A8I3WWM2
uniprot id: U3DD16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9483:RAP2B
gene id: 9483:RAP2B
uniprot id: F7IBL9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9483:GTF2B
gene id: 9483:GTF2B
uniprot id: A0A8I3ZYT9
uniprot id: U3EF86
names: Similarity
messages: Belongs to the TFIIB family.

9483:KCNG3
gene id: 9483:KCNG3
uniprot id: F7FFQ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:IL20
gene id: 9483:IL20
uniprot id: F6WZC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9483:BMX
gene id: 9483:BMX
uniprot id: F7A015
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9483:PMM2
gene id: 9483:PMM2
uniprot id: A0A8I3WEB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9483:TAFA2
gene id: 9483:TAFA2
uniprot id: F7DMM8
names: Similarity
messages: Belongs to the TAFA family.

9483:HSPH1
gene id: 9483:HSPH1
uniprot id: F7HN07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9483:IKBKB
gene id: 9483:IKBKB
uniprot id: F7IBM5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:TEKT2
gene id: 9483:TEKT2
uniprot id: F7G6Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9483:CDC42EP2
gene id: 9483:CDC42EP2
uniprot id: F7I5F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9483:LDLR
gene id: 9483:LDLR
uniprot id: U3DIM9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:PRPH2
gene id: 9483:PRPH2
uniprot id: F7HZ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9483:SPTLC3
gene id: 9483:SPTLC3
uniprot id: F7ARU6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9483:SLC25A32
gene id: 9483:SLC25A32
uniprot id: F7I546
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:SLBP
gene id: 9483:SLBP
uniprot id: U3DWT0
names: Similarity
messages: Belongs to the SLBP family.

9483:CALCB
gene id: 9483:CALCB
uniprot id: U3BRR6
names: Similarity
messages: Belongs to the calcitonin family.

9483:HSPD1
gene id: 9483:HSPD1
uniprot id: U3D4H6
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9483:BMP4
gene id: 9483:BMP4
uniprot id: A0A5F4VXA0
names: Similarity
messages: Belongs to the TGF-beta family.

9483:TTC9C
gene id: 9483:TTC9C
uniprot id: F7I606
names: Similarity
messages: Belongs to the TTC9 family.

9483:GOLGA5
gene id: 9483:GOLGA5
uniprot id: U3AUC3
uniprot id: U3ENU1
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.

9483:WNT2
gene id: 9483:WNT2
uniprot id: Q2QLG1
uniprot id: U3E233
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

9483:LOC100390960
gene id: 9483:LOC100390960
uniprot id: F7I4P8
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9483:ERLEC1
gene id: 9483:ERLEC1
uniprot id: A0A2R8M3S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum lumen
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

9483:RAB5IF
gene id: 9483:RAB5IF
uniprot id: A0A5F4WDB7
uniprot id: F7IE30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:NPM1
gene id: 9483:NPM1
uniprot id: F7FL37
names: Similarity
messages: Belongs to the nucleoplasmin family.

9483:LOC100401345
gene id: 9483:LOC100401345
uniprot id: A0A8I3WUH7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:GCK
gene id: 9483:GCK
uniprot id: A0A8I4A2C9
names: Similarity
messages: Belongs to the hexokinase family.

9483:XRN1
gene id: 9483:XRN1
uniprot id: F7GUR3
uniprot id: U3CD29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9483:GPER1
gene id: 9483:GPER1
uniprot id: F7G601
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ABAT
gene id: 9483:ABAT
uniprot id: U3CEZ2
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9483:IGFBP5
gene id: 9483:IGFBP5
uniprot id: F7HYX2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:EXOSC2
gene id: 9483:EXOSC2
uniprot id: A0A5F4VWK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9483:BCL7A
gene id: 9483:BCL7A
uniprot id: F6W7A2
uniprot id: U3C447
names: Similarity
messages: Belongs to the BCL7 family.

9483:KCNJ2
gene id: 9483:KCNJ2
uniprot id: F6W2Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

9483:ESYT1
gene id: 9483:ESYT1
uniprot id: F6RL52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:HACD4
gene id: 9483:HACD4
uniprot id: A0A8I3WTI7
uniprot id: F6WUZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:BBS5
gene id: 9483:BBS5
uniprot id: F7EG67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9483:GJC2
gene id: 9483:GJC2
uniprot id: F7H2L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:TACR1
gene id: 9483:TACR1
uniprot id: F7HYI8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9483:PRKCG
gene id: 9483:PRKCG
uniprot id: F7CPU6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane

9483:TMEM98
gene id: 9483:TMEM98
uniprot id: F6ZJ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9483:SLC6A4
gene id: 9483:SLC6A4
uniprot id: F7BZJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Synapse
messages: focal adhesion
messages: neuron projection

9483:ROGDI
gene id: 9483:ROGDI
uniprot id: U3BVX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Presynapse
messages: Vesicle
messages: synaptic vesicle

9483:ELOF1
gene id: 9483:ELOF1
uniprot id: F7ABX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9483:FIP1L1
gene id: 9483:FIP1L1
uniprot id: F6XL63
uniprot id: F7HU37
uniprot id: F7HU47
uniprot id: U3CCA9
uniprot id: U3D9W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9483:F9
gene id: 9483:F9
uniprot id: A0A8I3W9Z9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:IL18RAP
gene id: 9483:IL18RAP
uniprot id: F6X906
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9483:TUT4
gene id: 9483:TUT4
uniprot id: U3CNC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

9483:ACTR10
gene id: 9483:ACTR10
uniprot id: F7I3K4
names: Similarity
messages: Belongs to the actin family.

9483:ITPK1
gene id: 9483:ITPK1
uniprot id: U3E1V5
names: Similarity
messages: Belongs to the ITPK1 family.

9483:NOP58
gene id: 9483:NOP58
uniprot id: F7IB06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus
messages: nucleoplasm

9483:STX17
gene id: 9483:STX17
uniprot id: U3BX97
names: Similarity
messages: Belongs to the syntaxin family.

9483:LRWD1
gene id: 9483:LRWD1
uniprot id: U3EMU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRWD1 family.
messages: centrosome
messages: kinetochore
messages: telomere

9483:ART1
gene id: 9483:ART1
uniprot id: U3DQM6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9483:SSX4B
gene id: 9483:SSX4B
uniprot id: A0A2R8M6L0
names: Similarity
messages: Belongs to the SSX family.

9483:CPOX
gene id: 9483:CPOX
uniprot id: U3CYT7
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

9483:TBK1
gene id: 9483:TBK1
uniprot id: A0A8I3WD22
uniprot id: U3D758
names: Subcellular Location Annotation
messages: Cytoplasm

9483:CYP8B1
gene id: 9483:CYP8B1
uniprot id: A0A7G0Y586
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9483:GPRIN3
gene id: 9483:GPRIN3
uniprot id: U3FMS2
names: Function
messages: May be involved in neurite outgrowth.

9483:SEPTIN10
gene id: 9483:SEPTIN10
uniprot id: U3F240
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9483:SPCS2
gene id: 9483:SPCS2
uniprot id: F7IAN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:PIH1D1
gene id: 9483:PIH1D1
uniprot id: U3CVS6
names: Similarity
messages: Belongs to the PIH1 family.

9483:MED17
gene id: 9483:MED17
uniprot id: U3DKL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:SPIC
gene id: 9483:SPIC
uniprot id: F7HYR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:PFKFB4
gene id: 9483:PFKFB4
uniprot id: U3EVT9
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9483:DCLK1
gene id: 9483:DCLK1
uniprot id: A0A5F4WN18
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9483:CCL2
gene id: 9483:CCL2
uniprot id: A0A5F4WHC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:CDC42SE2
gene id: 9483:CDC42SE2
uniprot id: F7IIP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9483:DIS3
gene id: 9483:DIS3
uniprot id: F7CVL7
uniprot id: U3D226
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9483:ELOVL7
gene id: 9483:ELOVL7
uniprot id: F6VQ90
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9483:CYP2J2
gene id: 9483:CYP2J2
uniprot id: A0A1P8NQJ2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:SUPT4H1
gene id: 9483:SUPT4H1
uniprot id: H9KXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9483:TIMM17B
gene id: 9483:TIMM17B
uniprot id: F6Y398
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

9483:RHBDD1
gene id: 9483:RHBDD1
uniprot id: F7HNU5
names: Subcellular Location Annotation
messages: Membrane

9483:MRPL9
gene id: 9483:MRPL9
uniprot id: B0KWD3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

9483:GPR15
gene id: 9483:GPR15
uniprot id: F7GUM7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:MS4A5
gene id: 9483:MS4A5
uniprot id: F7BSN1
names: Similarity
messages: Belongs to the MS4A family.

9483:RLN3
gene id: 9483:RLN3
uniprot id: F7I420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9483:B3GALT4
gene id: 9483:B3GALT4
uniprot id: U3DX13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:LEPROT
gene id: 9483:LEPROT
uniprot id: A0A5F4VXX7
uniprot id: F7IAD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9483:GADD45GIP1
gene id: 9483:GADD45GIP1
uniprot id: U3DS82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

9483:NDUFS1
gene id: 9483:NDUFS1
uniprot id: A0A8I3WKW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

9483:ZDHHC5
gene id: 9483:ZDHHC5
uniprot id: F6XIT1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:ATXN2
gene id: 9483:ATXN2
uniprot id: F6SS84
names: Similarity
messages: Belongs to the ataxin-2 family.

9483:SH3GL3
gene id: 9483:SH3GL3
uniprot id: U3CYS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9483:SDHAF3
gene id: 9483:SDHAF3
uniprot id: A0A2R8M3V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9483:TFPI2
gene id: 9483:TFPI2
uniprot id: U3ENJ1
names: Subcellular Location Annotation
messages: Secreted

9483:TRDMT1
gene id: 9483:TRDMT1
uniprot id: F6URL6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9483:CNKSR3
gene id: 9483:CNKSR3
uniprot id: U3BPL9
names: Similarity
messages: Belongs to the CNKSR family.

9483:SLC2A1
gene id: 9483:SLC2A1
uniprot id: F6PYB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Membrane
messages: Photoreceptor inner segment

9483:CDC42EP1
gene id: 9483:CDC42EP1
uniprot id: F7B9V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9483:RHBDL2
gene id: 9483:RHBDL2
uniprot id: F7C7A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9483:NCAPG
gene id: 9483:NCAPG
uniprot id: F7GVY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9483:HMGB2
gene id: 9483:HMGB2
uniprot id: F7HD57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9483:CPSF7
gene id: 9483:CPSF7
uniprot id: F7HI00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9483:PITX3
gene id: 9483:PITX3
uniprot id: F7GQI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9483:HMBS
gene id: 9483:HMBS
uniprot id: U3FF00
names: Similarity
messages: Belongs to the HMBS family.

9483:PSMB5
gene id: 9483:PSMB5
uniprot id: A0A8J8XYY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9483:KCNK13
gene id: 9483:KCNK13
uniprot id: A0A5F4WKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9483:DHDH
gene id: 9483:DHDH
uniprot id: F7FPG8
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9483:THOC2
gene id: 9483:THOC2
uniprot id: B0KWH8
uniprot id: F7ESC3
uniprot id: U3CR12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A (By similarity).
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus
messages: Nucleus speckle
messages: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role for proper neuronal development.

9483:TNFSF14
gene id: 9483:TNFSF14
uniprot id: A0A8I3WAJ4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:LDAF1
gene id: 9483:LDAF1
uniprot id: F7I8L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9483:ZIC3
gene id: 9483:ZIC3
uniprot id: U3ER80
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9483:SCD
gene id: 9483:SCD
uniprot id: U3DJ56
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9483:MLEC
gene id: 9483:MLEC
uniprot id: F7IL56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:MYMK
gene id: 9483:MYMK
uniprot id: A0A8I4A636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9483:NAPB
gene id: 9483:NAPB
uniprot id: U3FUU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9483:GFM1
gene id: 9483:GFM1
uniprot id: U3E9C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9483:ZMPSTE24
gene id: 9483:ZMPSTE24
uniprot id: U3DGC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9483:CCNYL1
gene id: 9483:CCNYL1
uniprot id: F7HYI9
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9483:GK5
gene id: 9483:GK5
uniprot id: F7F132
names: Similarity
messages: Belongs to the FGGY kinase family.

9483:SPTBN1
gene id: 9483:SPTBN1
uniprot id: F7H0A9
uniprot id: U3CSG0
names: Similarity
messages: Belongs to the spectrin family.

9483:TMEM17
gene id: 9483:TMEM17
uniprot id: F7DAD8
names: Subcellular Location Annotation
messages: Membrane

9483:CD163
gene id: 9483:CD163
uniprot id: A0A8I3W566
uniprot id: U3DT72
uniprot id: U3F8N3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CCL5
gene id: 9483:CCL5
uniprot id: A0A5F4W4J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:MCOLN3
gene id: 9483:MCOLN3
uniprot id: F6RG56
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily.
messages: Channel activity is activated by PtdIns(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) (PubMed:29019979). Inhibited by lumenal H(+) and Na(+). The channel pore shows dynamic behavior and undergoes spontaneous, Ca(2+)-dependent modulation when conducting Ca(2+).
messages: Early endosome membrane
messages: Homotetramer (PubMed:29019979). Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific. May heterooligomerize with TRPV5 to form a functional distinct ion channel (By similarity). Interacts with GABARAPL2 (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: N-glycosylated.
messages: Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events (PubMed:29019979). Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (By similarity). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (By similarity).
messages: The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen.
messages: autophagosome membrane
messages: stereocilium membrane

9483:MRPL11
gene id: 9483:MRPL11
uniprot id: F7I4I1
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9483:CHEK1
gene id: 9483:CHEK1
uniprot id: A0A8I3W5B3
uniprot id: F7GZH4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9483:WNT6
gene id: 9483:WNT6
uniprot id: A0A5F4VXK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:CYP2D19
gene id: 9483:CYP2D19
uniprot id: A0A171P0Z0
uniprot id: O18992
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
messages: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes.

9483:LYRM1
gene id: 9483:LYRM1
uniprot id: F6RTD1
names: Similarity
messages: Belongs to the complex I LYR family.

9483:CYBASC3
gene id: 9483:CYBASC3
uniprot id: F7H7P9
names: Subcellular Location Annotation
messages: Membrane

9483:CCL19
gene id: 9483:CCL19
uniprot id: F7BQ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:MMD
gene id: 9483:MMD
uniprot id: A0A2R8MEW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9483:PAH
gene id: 9483:PAH
uniprot id: A0A8I4A1R1
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9483:SNRPA1
gene id: 9483:SNRPA1
uniprot id: F7IJG0
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9483:FGF6
gene id: 9483:FGF6
uniprot id: F7I4D7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:KRT222
gene id: 9483:KRT222
uniprot id: U3EVW2
names: Similarity
messages: Belongs to the intermediate filament family.

9483:DYNC1LI1
gene id: 9483:DYNC1LI1
uniprot id: U3DNE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9483:MCUB
gene id: 9483:MCUB
uniprot id: F7I7H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:RNMT
gene id: 9483:RNMT
uniprot id: U3EIZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9483:ARSJ
gene id: 9483:ARSJ
uniprot id: A0A8I3WK19
names: Similarity
messages: Belongs to the sulfatase family.

9483:CES4A
gene id: 9483:CES4A
uniprot id: F7A7N6
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9483:TMEM256
gene id: 9483:TMEM256
uniprot id: F6V825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9483:PPOX
gene id: 9483:PPOX
uniprot id: F7GX92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9483:IL6R
gene id: 9483:IL6R
uniprot id: Q0PIT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Membrane

9483:TOP2A
gene id: 9483:TOP2A
uniprot id: F6T9B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9483:PHKG1
gene id: 9483:PHKG1
uniprot id: U3CUK8
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9483:PCID2
gene id: 9483:PCID2
uniprot id: F6QNT5
names: Similarity
messages: Belongs to the CSN12 family.

9483:MDM1
gene id: 9483:MDM1
uniprot id: U3BUY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9483:FAM167A
gene id: 9483:FAM167A
uniprot id: F6U0Y2
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9483:CPT1B
gene id: 9483:CPT1B
uniprot id: U3EYN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:MAN1A1
gene id: 9483:MAN1A1
uniprot id: F6QEE1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9483:HBS1L
gene id: 9483:HBS1L
uniprot id: A0A5F4VQZ5
uniprot id: F7HXM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm

9483:SLC35D2
gene id: 9483:SLC35D2
uniprot id: F7GT05
uniprot id: F7IKP5
names: Subcellular Location Annotation
messages: Membrane

9483:DIPK2A
gene id: 9483:DIPK2A
uniprot id: U3CMQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9483:NDUFAF1
gene id: 9483:NDUFAF1
uniprot id: F7HZT7
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9483:GJD2
gene id: 9483:GJD2
uniprot id: F7H014
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:IZUMO4
gene id: 9483:IZUMO4
uniprot id: F7H3X4
uniprot id: U3EHC0
names: Similarity
messages: Belongs to the Izumo family.

9483:ZPR1
gene id: 9483:ZPR1
uniprot id: B0KWQ8
names: Similarity
messages: Belongs to the ZPR1 family.

9483:TMEM35A
gene id: 9483:TMEM35A
uniprot id: F7HTX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9483:BET1
gene id: 9483:BET1
uniprot id: A0A8I3X9Z6
uniprot id: U3BHD7
names: Subcellular Location Annotation
messages: Membrane

9483:HSD17B6
gene id: 9483:HSD17B6
uniprot id: F6TYQ7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:UNC45B
gene id: 9483:UNC45B
uniprot id: U3CNZ8
names: Subcellular Location Annotation
messages: A band
messages: Z line
messages: perinuclear region

9483:GPATCH1
gene id: 9483:GPATCH1
uniprot id: F6ZI94
names: Similarity
messages: Belongs to the GPATCH1 family.

9483:MGA
gene id: 9483:MGA
uniprot id: F7INH6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:MRPL19
gene id: 9483:MRPL19
uniprot id: U3B9S5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9483:GTF2H5
gene id: 9483:GTF2H5
uniprot id: F7HBD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9483:LIN28B
gene id: 9483:LIN28B
uniprot id: A0A2R8M7B5
names: Similarity
messages: Belongs to the lin-28 family.

9483:ARMC1
gene id: 9483:ARMC1
uniprot id: F7CGM3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9483:OLFR564
gene id: 9483:OLFR564
uniprot id: B0VX92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PLPP4
gene id: 9483:PLPP4
uniprot id: U3EQ67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9483:TRMO
gene id: 9483:TRMO
uniprot id: F7GKW7
uniprot id: F7GL28
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9483:LOC100405332
gene id: 9483:LOC100405332
uniprot id: F6UCC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9483:NDUFA8
gene id: 9483:NDUFA8
uniprot id: F7CDP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9483:PAM
gene id: 9483:PAM
uniprot id: A0A8J8XJX7
uniprot id: F7IJS3
uniprot id: U3F7L2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 2 Cu(2+) ions per subunit.
messages: Binds one Zn(2+) ion per subunit.
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9483:YIPF4
gene id: 9483:YIPF4
uniprot id: U3C455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:RAB33B
gene id: 9483:RAB33B
uniprot id: F7I2X6
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

9483:DIPK1A
gene id: 9483:DIPK1A
uniprot id: A0A8I3WV24
uniprot id: F7FIM1
names: Similarity
messages: Belongs to the DIPK family.

9483:LIAS
gene id: 9483:LIAS
uniprot id: F6ZHY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9483:UBE2L3
gene id: 9483:UBE2L3
uniprot id: F7I7Z9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:SLC12A5
gene id: 9483:SLC12A5
uniprot id: A0A8J8XPH1
uniprot id: U3CZY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9483:KRT17
gene id: 9483:KRT17
uniprot id: F7ANB4
names: Similarity
messages: Belongs to the intermediate filament family.

9483:CACNB4
gene id: 9483:CACNB4
uniprot id: F7GGT8
uniprot id: U3D4S4
uniprot id: U3EX85
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9483:ATP5PB
gene id: 9483:ATP5PB
uniprot id: F7GCT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9483:CD109
gene id: 9483:CD109
uniprot id: A0A2R8P684
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

9483:PGK2
gene id: 9483:PGK2
uniprot id: F7FGX4
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9483:CERS5
gene id: 9483:CERS5
uniprot id: F7F1C1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9483:PROKR2
gene id: 9483:PROKR2
uniprot id: A0A8I3WBY1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:SNX7
gene id: 9483:SNX7
uniprot id: A0A8J8YIN2
names: Similarity
messages: Belongs to the sorting nexin family.

9483:MRPS26
gene id: 9483:MRPS26
uniprot id: U3CMR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9483:PPP4R3B
gene id: 9483:PPP4R3B
uniprot id: U3DMP4
names: Similarity
messages: Belongs to the SMEK family.

9483:RPS9
gene id: 9483:RPS9
uniprot id: B0VXI8
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9483:ZHX2
gene id: 9483:ZHX2
uniprot id: F7I6W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9483:LBR
gene id: 9483:LBR
uniprot id: A0A8I3W699
uniprot id: A0A8I3WE83
uniprot id: U3BM96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9483:ENTREP3
gene id: 9483:ENTREP3
uniprot id: U3DCX5
uniprot id: U3E4E0
names: Similarity
messages: Belongs to the ENTREP family.

9483:HOMER2
gene id: 9483:HOMER2
uniprot id: F7IP78
uniprot id: U3D810
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9483:UTP23
gene id: 9483:UTP23
uniprot id: F7HWG8
names: Subcellular Location Annotation
messages: nucleolus

9483:DDX56
gene id: 9483:DDX56
uniprot id: F7IAV9
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9483:NR0B2
gene id: 9483:NR0B2
uniprot id: F7H657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9483:KCNJ16
gene id: 9483:KCNJ16
uniprot id: F7IRC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9483:RBM17
gene id: 9483:RBM17
uniprot id: F7INM9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9483:CRHBP
gene id: 9483:CRHBP
uniprot id: U3C1E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9483:FABP4
gene id: 9483:FABP4
uniprot id: F6SD36
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:SLC29A2
gene id: 9483:SLC29A2
uniprot id: U3D679
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9483:RASGRP3
gene id: 9483:RASGRP3
uniprot id: U3FQ81
names: Similarity
messages: Belongs to the RASGRP family.

9483:PMM1
gene id: 9483:PMM1
uniprot id: U3DRA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9483:GDF10
gene id: 9483:GDF10
uniprot id: F6UYX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9483:WARS2
gene id: 9483:WARS2
uniprot id: F7EFP4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9483:FAM131C
gene id: 9483:FAM131C
uniprot id: U3FI24
names: Similarity
messages: Belongs to the FAM131 family.

9483:RPL27
gene id: 9483:RPL27
uniprot id: F7I424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

9483:ENO2
gene id: 9483:ENO2
uniprot id: F6QLJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9483:ATP11A
gene id: 9483:ATP11A
uniprot id: A0A2R8N6S8
uniprot id: A0A8I3VWN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9483:CSE1L
gene id: 9483:CSE1L
uniprot id: F6Y7A9
uniprot id: F7BAH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9483:DLG1
gene id: 9483:DLG1
uniprot id: F6UVX1
uniprot id: F7IK82
uniprot id: U3E5S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9483:STAR
gene id: 9483:STAR
uniprot id: F7ALD0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9483:GMPPA
gene id: 9483:GMPPA
uniprot id: B0KWJ2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9483:NMNAT3
gene id: 9483:NMNAT3
uniprot id: A0A2R8MMF5
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9483:GBX2
gene id: 9483:GBX2
uniprot id: A0A2R8NEK0
names: Subcellular Location Annotation
messages: Nucleus

9483:PHETA2
gene id: 9483:PHETA2
uniprot id: H9KVS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9483:SCAND1
gene id: 9483:SCAND1
uniprot id: U3CYJ8
names: Subcellular Location Annotation
messages: Nucleus

9483:EMX2
gene id: 9483:EMX2
uniprot id: F7E5H5
names: Subcellular Location Annotation
messages: Nucleus

9483:TMPO
gene id: 9483:TMPO
uniprot id: F6YNR4
uniprot id: F7CUJ3
uniprot id: U3EN66
names: Similarity
messages: Belongs to the LEM family.

9483:PPP1R35
gene id: 9483:PPP1R35
uniprot id: F6VQG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP1R35 family.
messages: centriole

9483:MFAP1
gene id: 9483:MFAP1
uniprot id: B0KWG5
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9483:AP4E1
gene id: 9483:AP4E1
uniprot id: U3E0Y1
names: Function
names: Similarity
names: Subunit
messages: Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

9483:STMN4
gene id: 9483:STMN4
uniprot id: A0A8I3WA26
uniprot id: F6QV67
uniprot id: U3FXQ2
names: Similarity
messages: Belongs to the stathmin family.

9483:SLC26A2
gene id: 9483:SLC26A2
uniprot id: F7H3N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.

9483:TMEM45B
gene id: 9483:TMEM45B
uniprot id: U3D5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9483:ADAMTS3
gene id: 9483:ADAMTS3
uniprot id: F7IQZ2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:FUT9
gene id: 9483:FUT9
uniprot id: F7I511
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9483:CTBP2
gene id: 9483:CTBP2
uniprot id: F7I3J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9483:NPLOC4
gene id: 9483:NPLOC4
uniprot id: A0A8I3XDR6
uniprot id: U3CGX0
names: Similarity
messages: Belongs to the NPL4 family.

9483:TIMM17A
gene id: 9483:TIMM17A
uniprot id: F7IHY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9483:CCK
gene id: 9483:CCK
uniprot id: U3DR24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9483:PDK4
gene id: 9483:PDK4
uniprot id: F7GY25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9483:ITPKB
gene id: 9483:ITPKB
uniprot id: U3FPY5
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9483:LOC100896017
gene id: 9483:LOC100896017
uniprot id: A0A5F4WIS5
names: Similarity
messages: Belongs to the LCE family.

9483:SRC
gene id: 9483:SRC
uniprot id: A0A5F4W7Z4
uniprot id: F6W7M1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:CLNS1A
gene id: 9483:CLNS1A
uniprot id: A0A2R8MJB4
uniprot id: U3FEP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9483:CYB561
gene id: 9483:CYB561
uniprot id: A0A8I3X570
uniprot id: A0A8J8XKZ9
uniprot id: U3C0Q0
names: Subcellular Location Annotation
messages: Membrane

9483:PGAP3
gene id: 9483:PGAP3
uniprot id: F6Y4P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Membrane

9483:PRAME
gene id: 9483:PRAME
uniprot id: F7CS78
names: Similarity
messages: Belongs to the PRAME family.

9483:YPEL2
gene id: 9483:YPEL2
uniprot id: U3CVF8
names: Similarity
messages: Belongs to the yippee family.

9483:LOC108591261
gene id: 9483:LOC108591261
uniprot id: F7H244
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9483:GUCY1B1
gene id: 9483:GUCY1B1
uniprot id: U3FX94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9483:DDIT4
gene id: 9483:DDIT4
uniprot id: F6X5P2
names: Similarity
messages: Belongs to the DDIT4 family.

9483:XYLB
gene id: 9483:XYLB
uniprot id: F7GVM7
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9483:TRIM28
gene id: 9483:TRIM28
uniprot id: U3E3Y4
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ARL8B
gene id: 9483:ARL8B
uniprot id: F7I8E9
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: axon
messages: spindle

9483:GFOD2
gene id: 9483:GFOD2
uniprot id: U3F7H2
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9483:CD34
gene id: 9483:CD34
uniprot id: Q76II1
names: Subcellular Location Annotation
messages: Membrane

9483:GPC4
gene id: 9483:GPC4
uniprot id: U3DQ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9483:STRIP2
gene id: 9483:STRIP2
uniprot id: F6QYE5
names: Similarity
messages: Belongs to the STRIP family.

9483:EIF2AK3
gene id: 9483:EIF2AK3
uniprot id: F7GGK0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9483:IFRD1
gene id: 9483:IFRD1
uniprot id: F7IPH5
names: Similarity
messages: Belongs to the IFRD family.

9483:CLDN8
gene id: 9483:CLDN8
uniprot id: U3DEN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:VPS33A
gene id: 9483:VPS33A
uniprot id: A0A8I3VXI5
uniprot id: U3D5U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9483:AFF4
gene id: 9483:AFF4
uniprot id: B0KWQ0
names: Similarity
messages: Belongs to the AF4 family.

9483:LOC103792017
gene id: 9483:LOC103792017
uniprot id: A0A6G6XDN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9483:NRN1
gene id: 9483:NRN1
uniprot id: U3EMR7
names: Similarity
messages: Belongs to the neuritin family.

9483:FGGY
gene id: 9483:FGGY
uniprot id: U3F890
names: Similarity
messages: Belongs to the FGGY kinase family.

9483:GADD45G
gene id: 9483:GADD45G
uniprot id: F7HV04
names: Similarity
messages: Belongs to the GADD45 family.

9483:MED6
gene id: 9483:MED6
uniprot id: F7FFB0
uniprot id: U3EBM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9483:MCTS2
gene id: 9483:MCTS2
uniprot id: U3ECM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9483:HAO2
gene id: 9483:HAO2
uniprot id: F7AA83
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9483:HK2
gene id: 9483:HK2
uniprot id: F7HCY2
names: Similarity
messages: Belongs to the hexokinase family.

9483:HEXIM1
gene id: 9483:HEXIM1
uniprot id: F7F2K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9483:VAMP4
gene id: 9483:VAMP4
uniprot id: F6W2F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9483:PLA2G2F
gene id: 9483:PLA2G2F
uniprot id: F7DRN8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9483:ACLY
gene id: 9483:ACLY
uniprot id: F7DBY4
uniprot id: F7DSU4
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9483:DBX2
gene id: 9483:DBX2
uniprot id: U3CRZ0
names: Subcellular Location Annotation
messages: Nucleus

9483:TNNT2
gene id: 9483:TNNT2
uniprot id: F7HC37
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9483:NDUFAF3
gene id: 9483:NDUFAF3
uniprot id: F6VFE1
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

9483:DNASE2B
gene id: 9483:DNASE2B
uniprot id: F6WHU9
names: Similarity
messages: Belongs to the DNase II family.

9483:TFB1M
gene id: 9483:TFB1M
uniprot id: U3FDQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9483:FAM149B1
gene id: 9483:FAM149B1
uniprot id: F7HP81
names: Similarity
messages: Belongs to the FAM149 family.

9483:XKRX
gene id: 9483:XKRX
uniprot id: A0A5K1UT75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9483:ATP5IF1
gene id: 9483:ATP5IF1
uniprot id: F7IA10
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9483:BAAT
gene id: 9483:BAAT
uniprot id: A0A5F4W1S3
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9483:TARBP2
gene id: 9483:TARBP2
uniprot id: U3BZA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9483:TIMM10B
gene id: 9483:TIMM10B
uniprot id: F7AVF7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9483:POLR2G
gene id: 9483:POLR2G
uniprot id: U3DX33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9483:NDUFV2
gene id: 9483:NDUFV2
uniprot id: U3DYH6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9483:LOC100399525
gene id: 9483:LOC100399525
uniprot id: F7HZW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:KCNK9
gene id: 9483:KCNK9
uniprot id: F6TNM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9483:GPM6B
gene id: 9483:GPM6B
uniprot id: A0A2R8MIT5
uniprot id: A0A5F4WJL7
uniprot id: A0A5F4WK22
uniprot id: F6RKY6
uniprot id: F7I5V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9483:SCG5
gene id: 9483:SCG5
uniprot id: F7GV17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9483:DARS1
gene id: 9483:DARS1
uniprot id: F6ZUR7
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9483:CLRN3
gene id: 9483:CLRN3
uniprot id: F7I2G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9483:CMC2
gene id: 9483:CMC2
uniprot id: F6Z6C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9483:SERPINB12
gene id: 9483:SERPINB12
uniprot id: F7GMI6
names: Similarity
messages: Belongs to the serpin family.

9483:AMIGO3
gene id: 9483:AMIGO3
uniprot id: U3EPB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9483:ZDHHC24
gene id: 9483:ZDHHC24
uniprot id: U3EQW3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:TPST1
gene id: 9483:TPST1
uniprot id: F6PPZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9483:FTHL17
gene id: 9483:FTHL17
uniprot id: F7IIS6
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9483:MGST2
gene id: 9483:MGST2
uniprot id: U3D6F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:FMO4
gene id: 9483:FMO4
uniprot id: F7I9S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane

9483:CHMP7
gene id: 9483:CHMP7
uniprot id: U3DPV1
names: Similarity
messages: Belongs to the SNF7 family.

9483:SCNM1
gene id: 9483:SCNM1
uniprot id: B0KWB5
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: nucleoplasm

9483:UBE2E3
gene id: 9483:UBE2E3
uniprot id: F7CXA3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:PARG
gene id: 9483:PARG
uniprot id: F7DP34
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9483:MYO1B
gene id: 9483:MYO1B
uniprot id: A0A2R8MBT4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:CNNM1
gene id: 9483:CNNM1
uniprot id: A0A8I3WRG8
uniprot id: A0A8I3XE90
uniprot id: F7I103
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9483:CX3CR1
gene id: 9483:CX3CR1
uniprot id: F7I7I1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9483:HOATZ
gene id: 9483:HOATZ
uniprot id: A0A8I3W111
uniprot id: F6QYF5
names: Similarity
messages: Belongs to the HOATZ family.

9483:AKAP9
gene id: 9483:AKAP9
uniprot id: U3FQ11
names: Subcellular Location Annotation
messages: centrosome

9483:LOC100415269
gene id: 9483:LOC100415269
uniprot id: B0VXC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CA7
gene id: 9483:CA7
uniprot id: F7B798
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9483:EXOSC3
gene id: 9483:EXOSC3
uniprot id: U3FVL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm
messages: nucleolus

9483:GNG10
gene id: 9483:GNG10
uniprot id: F7ESA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:CYP3A5
gene id: 9483:CYP3A5
uniprot id: B1NL97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9483:ATP6V1B1
gene id: 9483:ATP6V1B1
uniprot id: F7B6Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9483:CUL3
gene id: 9483:CUL3
uniprot id: F7GYK0
names: Similarity
messages: Belongs to the cullin family.

9483:LOC108591240
gene id: 9483:LOC108591240
uniprot id: F7HQ77
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:PTX3
gene id: 9483:PTX3
uniprot id: U3FG41
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TMEM8B
gene id: 9483:TMEM8B
uniprot id: U3CJE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9483:ST6GALNAC4
gene id: 9483:ST6GALNAC4
uniprot id: F6ZK00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:LOC100405375
gene id: 9483:LOC100405375
uniprot id: F7FGR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9483:MID2
gene id: 9483:MID2
uniprot id: U3B1I8
uniprot id: U3EWX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Nucleus
messages: cytoskeleton

9483:TIGD2
gene id: 9483:TIGD2
uniprot id: U3AZP8
names: Subcellular Location Annotation
messages: Nucleus

9483:OSTC
gene id: 9483:OSTC
uniprot id: F7HL75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9483:DHRS11
gene id: 9483:DHRS11
uniprot id: U3CDC2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:SEH1L
gene id: 9483:SEH1L
uniprot id: F7EUR5
uniprot id: U3CY94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9483:ALG9
gene id: 9483:ALG9
uniprot id: U3DKC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:BEND6
gene id: 9483:BEND6
uniprot id: F6THU7
names: Subcellular Location Annotation
messages: Nucleus

9483:MRFAP1
gene id: 9483:MRFAP1
uniprot id: F6QM18
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9483:TMEM126B
gene id: 9483:TMEM126B
uniprot id: F7HZV3
names: Subcellular Location Annotation
messages: Membrane

9483:FGF20
gene id: 9483:FGF20
uniprot id: A0A7U3JW33
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:EXOSC1
gene id: 9483:EXOSC1
uniprot id: F6WV46
names: Subcellular Location Annotation
messages: Cytoplasm

9483:IFNB1
gene id: 9483:IFNB1
uniprot id: A0A7R8C316
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:CDC42EP3
gene id: 9483:CDC42EP3
uniprot id: U3BCL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9483:LOC100385441
gene id: 9483:LOC100385441
uniprot id: A0A2R8MBM5
uniprot id: U3F7H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:CHRM2
gene id: 9483:CHRM2
uniprot id: F7APE0
uniprot id: U3EXJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9483:LHX5
gene id: 9483:LHX5
uniprot id: F7I4X9
names: Subcellular Location Annotation
messages: Nucleus

9483:B4GALT1
gene id: 9483:B4GALT1
uniprot id: F7I1Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9483:LOC100895949
gene id: 9483:LOC100895949
uniprot id: A0A2R8PJM6
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9483:LOC100410611
gene id: 9483:LOC100410611
uniprot id: Q6WN28
uniprot id: U3FQP9
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9483:LOC100398645
gene id: 9483:LOC100398645
uniprot id: A0A8I3X648
names: Similarity
messages: Belongs to the actin family.

9483:EXTL2
gene id: 9483:EXTL2
uniprot id: F7G1W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:GTF2E2
gene id: 9483:GTF2E2
uniprot id: U3B951
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9483:PIP4P1
gene id: 9483:PIP4P1
uniprot id: F7I551
uniprot id: U3FEW4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9483:CADM1
gene id: 9483:CADM1
uniprot id: A0A2R8PKZ8
uniprot id: U3EZB7
names: Similarity
messages: Belongs to the nectin family.

9483:AKIRIN1
gene id: 9483:AKIRIN1
uniprot id: F7B8Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9483:PARP6
gene id: 9483:PARP6
uniprot id: U3E0E5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:CPA1
gene id: 9483:CPA1
uniprot id: F6WX16
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:CYP19A1
gene id: 9483:CYP19A1
uniprot id: F7HXX8
uniprot id: Q95M61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
messages: Membrane

9483:PTAR1
gene id: 9483:PTAR1
uniprot id: A0A2R8MTV6
uniprot id: A0A8I3ZYE6
uniprot id: A0A8J8XIP4
uniprot id: F7HUT4
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9483:FAM162A
gene id: 9483:FAM162A
uniprot id: F6VDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9483:DNER
gene id: 9483:DNER
uniprot id: F7G2V2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SSR4
gene id: 9483:SSR4
uniprot id: F7FX02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9483:LHFPL6
gene id: 9483:LHFPL6
uniprot id: U3EXN1
names: Subcellular Location Annotation
messages: Membrane

9483:PON2
gene id: 9483:PON2
uniprot id: F7D0R7
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9483:CPLX3
gene id: 9483:CPLX3
uniprot id: F6WRU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9483:SERPINB1
gene id: 9483:SERPINB1
uniprot id: F7ISC2
names: Similarity
messages: Belongs to the serpin family.

9483:ASB7
gene id: 9483:ASB7
uniprot id: U3EV99
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:ZC3H12C
gene id: 9483:ZC3H12C
uniprot id: A0A8I3WP39
names: Similarity
messages: Belongs to the ZC3H12 family.

9483:GNAO1
gene id: 9483:GNAO1
uniprot id: A0A2R8P4V7
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9483:GSTP1
gene id: 9483:GSTP1
uniprot id: U3EHV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

9483:SCG3
gene id: 9483:SCG3
uniprot id: A0A8I3XBG4
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: secretory vesicle membrane

9483:MST1
gene id: 9483:MST1
uniprot id: F6S5L7
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CD36
gene id: 9483:CD36
uniprot id: U3BY47
names: Similarity
messages: Belongs to the CD36 family.

9483:STING1
gene id: 9483:STING1
uniprot id: F7HWC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9483:RPL23
gene id: 9483:RPL23
uniprot id: A0A2R8PA32
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.

9483:SLC35A1
gene id: 9483:SLC35A1
uniprot id: U3BSW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:GRIA1
gene id: 9483:GRIA1
uniprot id: F7HTC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9483:MEPCE
gene id: 9483:MEPCE
uniprot id: U3E6A8
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9483:CSTPP1
gene id: 9483:CSTPP1
uniprot id: U3FM37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: cytoskeleton

9483:CLPX
gene id: 9483:CLPX
uniprot id: U3DAL1
names: Similarity
messages: Belongs to the ClpX chaperone family.

9483:IL9
gene id: 9483:IL9
uniprot id: F7HMS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

9483:SLC5A1
gene id: 9483:SLC5A1
uniprot id: B0KWS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9483:SLC17A9
gene id: 9483:SLC17A9
uniprot id: A0A8I3WJT7
names: Subcellular Location Annotation
messages: Membrane

9483:LOC100393688
gene id: 9483:LOC100393688
uniprot id: B0KWF4
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9483:PIAS3
gene id: 9483:PIAS3
uniprot id: U3FA04
names: Similarity
messages: Belongs to the PIAS family.

9483:GIMAP1
gene id: 9483:GIMAP1
uniprot id: F6Q1Z7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9483:SPARCL1
gene id: 9483:SPARCL1
uniprot id: U3F1M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9483:CD40LG
gene id: 9483:CD40LG
uniprot id: Q9BDN3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9483:ILDR1
gene id: 9483:ILDR1
uniprot id: F7GPP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9483:THEMIS
gene id: 9483:THEMIS
uniprot id: A0A8I3WY64
names: Similarity
messages: Belongs to the themis family.

9483:HNRNPK
gene id: 9483:HNRNPK
uniprot id: F7IK44
uniprot id: U3CKT0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9483:UTS2R
gene id: 9483:UTS2R
uniprot id: A0A2R8MIZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

9483:CLDN9
gene id: 9483:CLDN9
uniprot id: F7CV25
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:RECQL4
gene id: 9483:RECQL4
uniprot id: F7GFQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9483:CDC42EP5
gene id: 9483:CDC42EP5
uniprot id: B0VXJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9483:DEFA4
gene id: 9483:DEFA4
uniprot id: F6PJC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9483:GPRC5A
gene id: 9483:GPRC5A
uniprot id: F7IJ74
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:PPP1R14B
gene id: 9483:PPP1R14B
uniprot id: F6Q451
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9483:TRIM14
gene id: 9483:TRIM14
uniprot id: F7H1L9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:SLFN11
gene id: 9483:SLFN11
uniprot id: F7E9W8
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

9483:ATG9A
gene id: 9483:ATG9A
uniprot id: F6RC33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9483:SEMA4F
gene id: 9483:SEMA4F
uniprot id: F7I7T5
uniprot id: F7IA44
uniprot id: U3BXV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOC100389168
gene id: 9483:LOC100389168
uniprot id: A0A8I3X340
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:RFTN2
gene id: 9483:RFTN2
uniprot id: F6PHM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9483:RAB3D
gene id: 9483:RAB3D
uniprot id: F7I8G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9483:PARP12
gene id: 9483:PARP12
uniprot id: F7F9E2
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:CLDN20
gene id: 9483:CLDN20
uniprot id: A0A5F4W442
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:SAR1A
gene id: 9483:SAR1A
uniprot id: F6WCH0
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9483:POLR1A
gene id: 9483:POLR1A
uniprot id: F7H346
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9483:ID3
gene id: 9483:ID3
uniprot id: F7IIH1
names: Subcellular Location Annotation
messages: Nucleus

9483:LGI1
gene id: 9483:LGI1
uniprot id: A0A2R8MNW8
uniprot id: F7A305
names: Subcellular Location Annotation
messages: Secreted

9483:NDUFS2
gene id: 9483:NDUFS2
uniprot id: F7D5V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 49 kDa subunit family.
messages: Mitochondrion inner membrane

9483:CALHM6
gene id: 9483:CALHM6
uniprot id: F7IPY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9483:LETM1
gene id: 9483:LETM1
uniprot id: F7DVP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:SLC16A2
gene id: 9483:SLC16A2
uniprot id: A0A8I3WZ05
names: Subcellular Location Annotation
messages: Membrane

9483:IFI27L2
gene id: 9483:IFI27L2
uniprot id: F7I565
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9483:EVA1B
gene id: 9483:EVA1B
uniprot id: F7GUT3
names: Similarity
messages: Belongs to the EVA1 family.

9483:LGSN
gene id: 9483:LGSN
uniprot id: A0A5F4W1T8
uniprot id: F7DFP2
names: Similarity
messages: Belongs to the glutamine synthetase family.

9483:DCTN5
gene id: 9483:DCTN5
uniprot id: U3CVW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

9483:PDCL3
gene id: 9483:PDCL3
uniprot id: F7G7I6
names: Similarity
messages: Belongs to the phosducin family.

9483:LOC100387657
gene id: 9483:LOC100387657
uniprot id: F7GLL2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9483:MAP2K4
gene id: 9483:MAP2K4
uniprot id: A0A2R8MIZ6
uniprot id: A0A8I3WWX8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:SAMM50
gene id: 9483:SAMM50
uniprot id: U3DML6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9483:VPS52
gene id: 9483:VPS52
uniprot id: F7IGV6
names: Similarity
messages: Belongs to the VPS52 family.

9483:KIF2C
gene id: 9483:KIF2C
uniprot id: F6PQV2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:PAFAH1B1
gene id: 9483:PAFAH1B1
uniprot id: F7HWL4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: centrosome
messages: cytoskeleton
messages: spindle

9483:LRTOMT
gene id: 9483:LRTOMT
uniprot id: F6UJ98
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9483:NTMT2
gene id: 9483:NTMT2
uniprot id: F7FX50
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9483:ADH4
gene id: 9483:ADH4
uniprot id: A0A2R8MBZ6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9483:COMTD1
gene id: 9483:COMTD1
uniprot id: F6X318
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9483:FNTA
gene id: 9483:FNTA
uniprot id: F7H177
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9483:VPS26A
gene id: 9483:VPS26A
uniprot id: F7GXC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

9483:SSTR1
gene id: 9483:SSTR1
uniprot id: U3EYR3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:PSMB4
gene id: 9483:PSMB4
uniprot id: B0KWC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9483:RPS27
gene id: 9483:RPS27
uniprot id: B0VXF6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:COX8C
gene id: 9483:COX8C
uniprot id: A0A8I3WL11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9483:SNX2
gene id: 9483:SNX2
uniprot id: F7IH18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9483:TM6SF1
gene id: 9483:TM6SF1
uniprot id: U3CXX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

9483:SLC27A1
gene id: 9483:SLC27A1
uniprot id: F7B110
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:METTL6
gene id: 9483:METTL6
uniprot id: U3CI44
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9483:LOC100406557
gene id: 9483:LOC100406557
uniprot id: A0A8I3WMT9
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9483:TM4SF1
gene id: 9483:TM4SF1
uniprot id: F6S9T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9483:SIGMAR1
gene id: 9483:SIGMAR1
uniprot id: F6YPR0
uniprot id: U3DT67
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle
messages: growth cone

9483:AMZ2
gene id: 9483:AMZ2
uniprot id: F7FPH4
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

9483:TMEM70
gene id: 9483:TMEM70
uniprot id: F7C1U3
names: Similarity
messages: Belongs to the TMEM70 family.

9483:RND3
gene id: 9483:RND3
uniprot id: F7HJC5
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9483:LOC100403511
gene id: 9483:LOC100403511
uniprot id: F6Y4Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9483:PSMD11
gene id: 9483:PSMD11
uniprot id: F7HPV3
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9483:CHMP5
gene id: 9483:CHMP5
uniprot id: F7I3H4
names: Similarity
messages: Belongs to the SNF7 family.

9483:MFSD4A
gene id: 9483:MFSD4A
uniprot id: U3B6V7
names: Subcellular Location Annotation
messages: Membrane

9483:RNF34
gene id: 9483:RNF34
uniprot id: F7IKY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: cytosol

9483:HYI
gene id: 9483:HYI
uniprot id: F7GQR5
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

9483:TACC2
gene id: 9483:TACC2
uniprot id: U3EDY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

9483:TMEM199
gene id: 9483:TMEM199
uniprot id: F7HX53
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:TMEM33
gene id: 9483:TMEM33
uniprot id: F7F832
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9483:ARHGEF12
gene id: 9483:ARHGEF12
uniprot id: A0A5F4VTL2
uniprot id: U3D1J4
uniprot id: U3EDT1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9483:TRPC3
gene id: 9483:TRPC3
uniprot id: U3FM83
names: Subcellular Location Annotation
messages: Membrane

9483:IL6
gene id: 9483:IL6
uniprot id: Q0Z973
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9483:APH1B
gene id: 9483:APH1B
uniprot id: U3BNX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9483:PFN1
gene id: 9483:PFN1
uniprot id: F6PID5
names: Similarity
messages: Belongs to the profilin family.

9483:EFEMP2
gene id: 9483:EFEMP2
uniprot id: U3CJ36
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:COG1
gene id: 9483:COG1
uniprot id: F6XYA7
names: Similarity
messages: Belongs to the COG1 family.

9483:PPARG
gene id: 9483:PPARG
uniprot id: F6T9U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9483:NAE1
gene id: 9483:NAE1
uniprot id: U3F0P7
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

9483:GSTO1
gene id: 9483:GSTO1
uniprot id: U3DX59
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9483:GRID2
gene id: 9483:GRID2
uniprot id: F7E4U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9483:ZGPAT
gene id: 9483:ZGPAT
uniprot id: F7B996
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CHD4/Mi-2; the interaction is direct.
messages: Nucleus

9483:LOC100402350
gene id: 9483:LOC100402350
uniprot id: F7GGF4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PROZ
gene id: 9483:PROZ
uniprot id: F7H321
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MS4A7
gene id: 9483:MS4A7
uniprot id: F6V8V9
names: Similarity
messages: Belongs to the MS4A family.

9483:CFAP300
gene id: 9483:CFAP300
uniprot id: A0A2R8PIC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9483:ZWILCH
gene id: 9483:ZWILCH
uniprot id: A0A8J8XJB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
messages: kinetochore

9483:ITGB1
gene id: 9483:ITGB1
uniprot id: U3BF89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9483:CRKL
gene id: 9483:CRKL
uniprot id: F7HYH0
names: Similarity
messages: Belongs to the CRK family.

9483:UST
gene id: 9483:UST
uniprot id: U3DQZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:PRSS12
gene id: 9483:PRSS12
uniprot id: F7ERX9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

9483:DDX1
gene id: 9483:DDX1
uniprot id: U3D3H9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasmic granule
messages: Nucleus
messages: RNA helicase.
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.

9483:CKMT2
gene id: 9483:CKMT2
uniprot id: F7G223
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9483:SAE1
gene id: 9483:SAE1
uniprot id: F6QHC3
uniprot id: U3C0S2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9483:AKR1C1
gene id: 9483:AKR1C1
uniprot id: U3FQT3
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9483:HEATR5B
gene id: 9483:HEATR5B
uniprot id: F7CXW2
names: Similarity
messages: Belongs to the HEATR5 family.

9483:EID1
gene id: 9483:EID1
uniprot id: F7GI85
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100408081
gene id: 9483:LOC100408081
uniprot id: A0A2R8MGA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:UBP1
gene id: 9483:UBP1
uniprot id: A0A2R8M7A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9483:PAX6
gene id: 9483:PAX6
uniprot id: F6QG77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the paired homeobox family.
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

9483:FSD1L
gene id: 9483:FSD1L
uniprot id: U3D2E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:PPP1R21
gene id: 9483:PPP1R21
uniprot id: F7FNC9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9483:NELFCD
gene id: 9483:NELFCD
uniprot id: F7HUP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

9483:INHA
gene id: 9483:INHA
uniprot id: B0KWJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9483:AASDHPPT
gene id: 9483:AASDHPPT
uniprot id: U3FNY9
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

9483:CAVIN1
gene id: 9483:CAVIN1
uniprot id: F6U9J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9483:HADH
gene id: 9483:HADH
uniprot id: U3ERY1
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9483:CHAC2
gene id: 9483:CHAC2
uniprot id: A0A5F4WMD6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9483:NSFL1C
gene id: 9483:NSFL1C
uniprot id: U3CGN9
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9483:SLC25A15
gene id: 9483:SLC25A15
uniprot id: U3CT12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:EDC4
gene id: 9483:EDC4
uniprot id: A0A5K1UHY1
uniprot id: U3E1X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9483:UBALD1
gene id: 9483:UBALD1
uniprot id: A0A2R8MPE1
names: Similarity
messages: Belongs to the UBALD family.

9483:ARGLU1
gene id: 9483:ARGLU1
uniprot id: F7FFN5
names: Similarity
messages: Belongs to the UPF0430 family.

9483:MMS22L
gene id: 9483:MMS22L
uniprot id: A0A8I3X025
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Nucleus

9483:SPACA3
gene id: 9483:SPACA3
uniprot id: F7I955
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9483:SUB1
gene id: 9483:SUB1
uniprot id: F7I1C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9483:CDH2
gene id: 9483:CDH2
uniprot id: B0KW95
uniprot id: F7HZT3
uniprot id: U3FY48
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
messages: Cell junction
messages: Cell membrane
messages: Cell surface
messages: Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa N-terminal soluble fragment and a 45 kDa membrane-bound C-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa (By similarity). Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).
messages: Homodimer (via extracellular region). Can also form heterodimers with other cadherins (via extracellular region). Dimerization occurs in trans, i.e. with a cadherin chain from another cell (By similarity). Interacts with CDCP1 (By similarity). Interacts with PCDH8; this complex may also include TAOK2 (By similarity). The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. May interact with OBSCN (via protein kinase domain 2) (By similarity). Interacts with FBXO45 (By similarity).
messages: Membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1.
messages: adherens junction
messages: desmosome
messages: sarcolemma

9483:PTGR2
gene id: 9483:PTGR2
uniprot id: A0A8I3WNV1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9483:TPM2
gene id: 9483:TPM2
uniprot id: U3CKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9483:ACTL8
gene id: 9483:ACTL8
uniprot id: F7HR35
names: Similarity
messages: Belongs to the actin family.

9483:FBXO32
gene id: 9483:FBXO32
uniprot id: U3ERG3
names: Subcellular Location Annotation
messages: Nucleus

9483:NAA10
gene id: 9483:NAA10
uniprot id: B0KWW1
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9483:EPC2
gene id: 9483:EPC2
uniprot id: A0A5F4VS20
uniprot id: F7IQD8
uniprot id: U3CP32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9483:CSNK1D
gene id: 9483:CSNK1D
uniprot id: F6PU42
uniprot id: F6QGM4
uniprot id: F6QSB7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:CLCA1
gene id: 9483:CLCA1
uniprot id: F7CTH0
names: Similarity
messages: Belongs to the CLCR family.

9483:GH1
gene id: 9483:GH1
uniprot id: A0AAU6
uniprot id: Q9GMB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity).
messages: Secreted

9483:ITGA3
gene id: 9483:ITGA3
uniprot id: F6S164
uniprot id: F7GGD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9483:LOC100894532
gene id: 9483:LOC100894532
uniprot id: B0VXC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:MCEE
gene id: 9483:MCEE
uniprot id: A0A5F4W3C0
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9483:IRF3
gene id: 9483:IRF3
uniprot id: F7HB60
names: Subcellular Location Annotation
messages: Nucleus

9483:WSCD2
gene id: 9483:WSCD2
uniprot id: U3CR93
names: Function
names: Similarity
messages: Belongs to the WSCD family.
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9483:LGI4
gene id: 9483:LGI4
uniprot id: U3BGF6
names: Subcellular Location Annotation
messages: Secreted

9483:TMED1
gene id: 9483:TMED1
uniprot id: F7D6C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9483:CHMP3
gene id: 9483:CHMP3
uniprot id: F7GN92
names: Similarity
messages: Belongs to the SNF7 family.

9483:ASB15
gene id: 9483:ASB15
uniprot id: A0A8I3W2Y7
uniprot id: U3DDH4
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:COR52P3
gene id: 9483:COR52P3
uniprot id: B0VXD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:MTMR12
gene id: 9483:MTMR12
uniprot id: A0A8I3XAX9
uniprot id: U3EEE5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9483:SEMA6D
gene id: 9483:SEMA6D
uniprot id: F7H9T7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOC100894628
gene id: 9483:LOC100894628
uniprot id: F7IQR5
names: Similarity
messages: Belongs to the UQCC4 family.

9483:TRIM17
gene id: 9483:TRIM17
uniprot id: F7AML3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:CRYBB2
gene id: 9483:CRYBB2
uniprot id: U3F629
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9483:RPL30
gene id: 9483:RPL30
uniprot id: F6WQV8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9483:LOC103788995
gene id: 9483:LOC103788995
uniprot id: F7H071
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9483:GCHFR
gene id: 9483:GCHFR
uniprot id: F7IKX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9483:TPPP
gene id: 9483:TPPP
uniprot id: U3C144
names: Similarity
messages: Belongs to the TPPP family.

9483:PYCR1
gene id: 9483:PYCR1
uniprot id: A0A8I3X6M6
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9483:YTHDF1
gene id: 9483:YTHDF1
uniprot id: F7GJA0
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9483:FAM174A
gene id: 9483:FAM174A
uniprot id: F7IRI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9483:CMTM3
gene id: 9483:CMTM3
uniprot id: A0A8J8XIN1
names: Subcellular Location Annotation
messages: Membrane

9483:KITLG
gene id: 9483:KITLG
uniprot id: F7G0W2
uniprot id: F7G0Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

9483:DR1
gene id: 9483:DR1
uniprot id: A0A2R8MT44
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9483:FOXP1
gene id: 9483:FOXP1
uniprot id: A0A8I3W5Y5
uniprot id: U3FVN3
names: Subcellular Location Annotation
messages: Nucleus

9483:ERGIC3
gene id: 9483:ERGIC3
uniprot id: B0KWM1
uniprot id: F7EQK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9483:RNF185
gene id: 9483:RNF185
uniprot id: F7HCL9
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9483:CAJA-E
gene id: 9483:CAJA-E
uniprot id: A0FJB5
names: Similarity
messages: Belongs to the MHC class I family.

9483:TRIM68
gene id: 9483:TRIM68
uniprot id: U3EE72
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:NOP14
gene id: 9483:NOP14
uniprot id: F7IE93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9483:ATXN3
gene id: 9483:ATXN3
uniprot id: F6SV02
names: Subcellular Location Annotation
messages: Nucleus

9483:TSPYL1
gene id: 9483:TSPYL1
uniprot id: U3BLB6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:GPR108
gene id: 9483:GPR108
uniprot id: U3EP34
names: Subcellular Location Annotation
messages: Membrane

9483:CZIB
gene id: 9483:CZIB
uniprot id: F7IHX7
names: Similarity
messages: Belongs to the UPF0587 family.

9483:MGME1
gene id: 9483:MGME1
uniprot id: F7II48
uniprot id: U3F3A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGME1 family.
messages: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.
messages: Mitochondrion

9483:MPC1
gene id: 9483:MPC1
uniprot id: A0A8I3XDU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9483:CCDC181
gene id: 9483:CCDC181
uniprot id: U3DQV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

9483:FPGS
gene id: 9483:FPGS
uniprot id: F6QU94
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

9483:ABITRAM
gene id: 9483:ABITRAM
uniprot id: U3FJK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9483:PDSS2
gene id: 9483:PDSS2
uniprot id: A0A2R8P504
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9483:RETREG1
gene id: 9483:RETREG1
uniprot id: F7ECF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:STRA6
gene id: 9483:STRA6
uniprot id: F7BJF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:NFIL3
gene id: 9483:NFIL3
uniprot id: F7II13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9483:FAM3A
gene id: 9483:FAM3A
uniprot id: B0KWT8
uniprot id: U3E9S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9483:CACNA2D3
gene id: 9483:CACNA2D3
uniprot id: F7IIU4
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9483:HEBP1
gene id: 9483:HEBP1
uniprot id: F7IJ77
names: Similarity
messages: Belongs to the HEBP family.

9483:LOC108589342
gene id: 9483:LOC108589342
uniprot id: A0A8I3WMQ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:MANBA
gene id: 9483:MANBA
uniprot id: A0A5F4W139
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9483:RO60
gene id: 9483:RO60
uniprot id: F6ZHA8
uniprot id: U3FLM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9483:MPPED2
gene id: 9483:MPPED2
uniprot id: U3BEC4
names: Similarity
messages: Belongs to the UPF0046 family.

9483:MYOD1
gene id: 9483:MYOD1
uniprot id: U3FGJ7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9483:AZIN2
gene id: 9483:AZIN2
uniprot id: F7I7B9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9483:LCAT
gene id: 9483:LCAT
uniprot id: A0A8I3WUV1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9483:ORC2
gene id: 9483:ORC2
uniprot id: U3CG13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9483:CEBPZ
gene id: 9483:CEBPZ
uniprot id: U3F1A1
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9483:LOC100409740
gene id: 9483:LOC100409740
uniprot id: A0A8I4A680
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:ZMYND10
gene id: 9483:ZMYND10
uniprot id: F7GCB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite

9483:WWOX
gene id: 9483:WWOX
uniprot id: U3FE30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Lysosome
messages: Mitochondrion

9483:TMEM38B
gene id: 9483:TMEM38B
uniprot id: F7HYQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9483:PSENEN
gene id: 9483:PSENEN
uniprot id: F7DH46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9483:S100A16
gene id: 9483:S100A16
uniprot id: F7AMA4
names: Similarity
messages: Belongs to the S-100 family.

9483:TRAM1
gene id: 9483:TRAM1
uniprot id: F7INC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9483:ADH7
gene id: 9483:ADH7
uniprot id: A0A5K1TXR1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9483:GIMAP4
gene id: 9483:GIMAP4
uniprot id: F6XVX4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9483:KAT6B
gene id: 9483:KAT6B
uniprot id: A0A5F4W2A5
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

9483:RBFOX3
gene id: 9483:RBFOX3
uniprot id: F7I9Y0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9483:SGF29
gene id: 9483:SGF29
uniprot id: U3FNH1
names: Subcellular Location Annotation
messages: Nucleus

9483:NPHS2
gene id: 9483:NPHS2
uniprot id: F7G7A4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9483:ACAT2
gene id: 9483:ACAT2
uniprot id: F7H488
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9483:TMEM200A
gene id: 9483:TMEM200A
uniprot id: F7HRG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9483:MAN2A2
gene id: 9483:MAN2A2
uniprot id: F7A987
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9483:ATL3
gene id: 9483:ATL3
uniprot id: F7CPC5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9483:SDHB
gene id: 9483:SDHB
uniprot id: F7IQK8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9483:CAP1
gene id: 9483:CAP1
uniprot id: F7I0Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9483:FASLG
gene id: 9483:FASLG
uniprot id: F7I0V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9483:PAX3
gene id: 9483:PAX3
uniprot id: F7BBQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the paired homeobox family.
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

9483:PCBD1
gene id: 9483:PCBD1
uniprot id: A0A2R8MHV7
uniprot id: F7GPT5
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9483:NTF4
gene id: 9483:NTF4
uniprot id: F7HA42
names: Similarity
messages: Belongs to the NGF-beta family.

9483:DERL1
gene id: 9483:DERL1
uniprot id: F6U3W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9483:CRPPA
gene id: 9483:CRPPA
uniprot id: A0A2R8P6J5
uniprot id: A0A8I3W7B7
uniprot id: A0A8I3WGM6
uniprot id: A0A8I3WNV3
uniprot id: F6YEP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Homodimer.
messages: cytosol

9483:FOXO1
gene id: 9483:FOXO1
uniprot id: U3FDL3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:DDX6
gene id: 9483:DDX6
uniprot id: F7A1X2
names: Similarity
messages: Belongs to the DEAD box helicase family.

9483:FDFT1
gene id: 9483:FDFT1
uniprot id: F6TRY2
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9483:UBE2A
gene id: 9483:UBE2A
uniprot id: F6SPE3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:PGAP1
gene id: 9483:PGAP1
uniprot id: U3CFJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9483:AFF1
gene id: 9483:AFF1
uniprot id: U3E6U6
uniprot id: U3FG32
names: Similarity
messages: Belongs to the AF4 family.

9483:INIP
gene id: 9483:INIP
uniprot id: F7H151
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9483:PSMC6
gene id: 9483:PSMC6
uniprot id: F6X828
names: Similarity
messages: Belongs to the AAA ATPase family.

9483:PLK4
gene id: 9483:PLK4
uniprot id: F7E1H1
uniprot id: U3D9B8
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: centriole

9483:SF3B4
gene id: 9483:SF3B4
uniprot id: F7GK55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9483:CNFN
gene id: 9483:CNFN
uniprot id: F7FLV5
names: Similarity
messages: Belongs to the cornifelin family.

9483:NODAL
gene id: 9483:NODAL
uniprot id: F7I2K8
names: Similarity
messages: Belongs to the TGF-beta family.

9483:AGA
gene id: 9483:AGA
uniprot id: U3CEY9
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9483:TOP1
gene id: 9483:TOP1
uniprot id: F6STR2
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9483:HECTD1
gene id: 9483:HECTD1
uniprot id: F7HZ46
uniprot id: U3BSJ6
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

9483:MPI
gene id: 9483:MPI
uniprot id: U3CWX3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9483:GALNT5
gene id: 9483:GALNT5
uniprot id: A0A5F4WAB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:RPL27A
gene id: 9483:RPL27A
uniprot id: F6S6U2
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9483:TNFRSF1A
gene id: 9483:TNFRSF1A
uniprot id: F6UYQ7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CSAD
gene id: 9483:CSAD
uniprot id: A0A8I4A5Y3
names: Similarity
messages: Belongs to the group II decarboxylase family.

9483:TMEM150C
gene id: 9483:TMEM150C
uniprot id: F7BRN5
names: Subcellular Location Annotation
messages: Membrane

9483:RPRD1A
gene id: 9483:RPRD1A
uniprot id: F7GW04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

9483:RICTOR
gene id: 9483:RICTOR
uniprot id: F7HVJ0
uniprot id: U3DS95
names: Similarity
messages: Belongs to the RICTOR family.

9483:THYN1
gene id: 9483:THYN1
uniprot id: F7CZ83
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9483:TUBA4A
gene id: 9483:TUBA4A
uniprot id: F7HZP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9483:RPS19
gene id: 9483:RPS19
uniprot id: F7DXF3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

9483:SEC23A
gene id: 9483:SEC23A
uniprot id: U3CYE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9483:NPY
gene id: 9483:NPY
uniprot id: F7HVB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9483:FOXP2
gene id: 9483:FOXP2
uniprot id: F7IF16
names: Subcellular Location Annotation
messages: Nucleus

9483:FZD7
gene id: 9483:FZD7
uniprot id: F7I3D1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:C1D
gene id: 9483:C1D
uniprot id: F7HJF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9483:AMER1
gene id: 9483:AMER1
uniprot id: F7GVN4
names: Similarity
messages: Belongs to the Amer family.

9483:FADS3
gene id: 9483:FADS3
uniprot id: U3B9H6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:GABRA4
gene id: 9483:GABRA4
uniprot id: A0A8I3WPF1
uniprot id: F7IFW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:LOC100410248
gene id: 9483:LOC100410248
uniprot id: B0VXB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:IREB2
gene id: 9483:IREB2
uniprot id: F6T5R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

9483:NLGN3
gene id: 9483:NLGN3
uniprot id: F7DYQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9483:SPC24
gene id: 9483:SPC24
uniprot id: F7HYV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9483:RUSF1
gene id: 9483:RUSF1
uniprot id: U3E5E9
names: Similarity
messages: Belongs to the RUS1 family.

9483:EMP1
gene id: 9483:EMP1
uniprot id: F7ILG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9483:FGF5
gene id: 9483:FGF5
uniprot id: F7DBG3
uniprot id: F7G2W7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:CUL4B
gene id: 9483:CUL4B
uniprot id: A0A8I3WVL3
uniprot id: A0A8I3ZYC6
names: Similarity
messages: Belongs to the cullin family.

9483:SETD7
gene id: 9483:SETD7
uniprot id: U3AWL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9483:LOC100407409
gene id: 9483:LOC100407409
uniprot id: A0A2R8M558
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:LOC100406994
gene id: 9483:LOC100406994
uniprot id: A0A5F4VRT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CLUAP1
gene id: 9483:CLUAP1
uniprot id: A0A8J8XFW6
uniprot id: F7HDE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9483:EIF4A1
gene id: 9483:EIF4A1
uniprot id: U3DYJ0
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9483:LOC100399755
gene id: 9483:LOC100399755
uniprot id: Q95MG6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Phosphorylated on the C-terminal cytoplasmic tail.
messages: Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9483:ERG
gene id: 9483:ERG
uniprot id: A0A2R8M9X4
uniprot id: A0A2R8PEF7
uniprot id: F7F2B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:MED18
gene id: 9483:MED18
uniprot id: F7HVT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:H1F0
gene id: 9483:H1F0
uniprot id: F7IAQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9483:OR2T4
gene id: 9483:OR2T4
uniprot id: F6TMH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ACER2
gene id: 9483:ACER2
uniprot id: F7IBP9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:LOC100390297
gene id: 9483:LOC100390297
uniprot id: B0VX93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:KCTD10
gene id: 9483:KCTD10
uniprot id: A0A5K1UDP4
uniprot id: U3E2C8
names: Similarity
messages: Belongs to the BACURD family.

9483:APOBEC3G
gene id: 9483:APOBEC3G
uniprot id: C0KTR7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm
messages: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.
messages: Homodimer.
messages: Nucleus
messages: P-body
messages: The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.

9483:XRCC6
gene id: 9483:XRCC6
uniprot id: U3FBT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

9483:E2F7
gene id: 9483:E2F7
uniprot id: A0A2R8M8J5
uniprot id: F7E4B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9483:PRM2
gene id: 9483:PRM2
uniprot id: Q28337
uniprot id: U3B7U7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protamine P2 family.
messages: Chromosome
messages: Interacts with TDRP.
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Proteolytic processing into mature chains is required for histone eviction during spermatogenesis. Transition proteins (TNP1 and TNP2) are required for processing.
messages: Testis.

9483:TAGLN
gene id: 9483:TAGLN
uniprot id: F7I1Q9
names: Similarity
messages: Belongs to the calponin family.

9483:NGFR
gene id: 9483:NGFR
uniprot id: F7C0A9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:RTN3
gene id: 9483:RTN3
uniprot id: F6WF07
uniprot id: U3EY57
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:GLE1
gene id: 9483:GLE1
uniprot id: F7AHA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

9483:IMPA2
gene id: 9483:IMPA2
uniprot id: U3DAH9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9483:UGGT1
gene id: 9483:UGGT1
uniprot id: U3DBX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9483:PYGL
gene id: 9483:PYGL
uniprot id: U3CPB0
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9483:PGAM1
gene id: 9483:PGAM1
uniprot id: F6Y5Q5
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9483:YWHAZ
gene id: 9483:YWHAZ
uniprot id: U3E3R3
names: Similarity
messages: Belongs to the 14-3-3 family.

9483:NUP98
gene id: 9483:NUP98
uniprot id: F6Z5L4
uniprot id: U3EEI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

9483:PSMA2
gene id: 9483:PSMA2
uniprot id: F7IE60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:SH2D1A
gene id: 9483:SH2D1A
uniprot id: A0A8I3X5W5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9483:MB
gene id: 9483:MB
uniprot id: F6PMG4
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9483:SF3A1
gene id: 9483:SF3A1
uniprot id: U3FGV5
names: Subcellular Location Annotation
messages: Nucleus

9483:GNA15
gene id: 9483:GNA15
uniprot id: F7I539
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9483:BOLA1
gene id: 9483:BOLA1
uniprot id: F7CF23
names: Similarity
messages: Belongs to the BolA/IbaG family.

9483:ITGAX
gene id: 9483:ITGAX
uniprot id: A6N6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9483:OTUB2
gene id: 9483:OTUB2
uniprot id: A0A2R8MS46
names: Similarity
messages: Belongs to the peptidase C65 family.

9483:HOXD8
gene id: 9483:HOXD8
uniprot id: U3E6J0
names: Subcellular Location Annotation
messages: Nucleus

9483:TRPC1
gene id: 9483:TRPC1
uniprot id: U3D194
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9483:MEIS2
gene id: 9483:MEIS2
uniprot id: A0A2R8PDQ0
uniprot id: F7EAH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9483:LOC100407742
gene id: 9483:LOC100407742
uniprot id: U3ELW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9483:ESCO1
gene id: 9483:ESCO1
uniprot id: A0A8J8Y947
names: Subcellular Location Annotation
messages: Nucleus

9483:MICOS13
gene id: 9483:MICOS13
uniprot id: U3C9P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9483:DCC
gene id: 9483:DCC
uniprot id: F7H4V7
uniprot id: U3F0X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9483:AP1S3
gene id: 9483:AP1S3
uniprot id: A0A2R8M4W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Membrane
messages: clathrin-coated pit

9483:FSHB
gene id: 9483:FSHB
uniprot id: F7IQC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9483:OOEP
gene id: 9483:OOEP
uniprot id: B0KWA6
names: Similarity
messages: Belongs to the KHDC1 family.

9483:SYBU
gene id: 9483:SYBU
uniprot id: A0A5F4W3A6
uniprot id: F7H9H4
uniprot id: F7IMS6
names: Subcellular Location Annotation
messages: Membrane

9483:CACYBP
gene id: 9483:CACYBP
uniprot id: U3B8Y1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9483:LOC103794241
gene id: 9483:LOC103794241
uniprot id: A0A5F4WF65
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

9483:CREBL2
gene id: 9483:CREBL2
uniprot id: A0A2R8PH20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9483:IL1RAP
gene id: 9483:IL1RAP
uniprot id: F6QTT3
uniprot id: F7IE70
uniprot id: U3BCW8
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9483:RHCE
gene id: 9483:RHCE
uniprot id: F7I3R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9483:PNKD
gene id: 9483:PNKD
uniprot id: F6YQM1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9483:EEF1B2
gene id: 9483:EEF1B2
uniprot id: F7GY27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9483:LOC100399107
gene id: 9483:LOC100399107
uniprot id: A0A8I3W5H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9483:ARPC3
gene id: 9483:ARPC3
uniprot id: F7IHC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9483:TMEM184B
gene id: 9483:TMEM184B
uniprot id: U3BZH9
uniprot id: U3EME4
names: Subcellular Location Annotation
messages: Membrane

9483:LOC103794898
gene id: 9483:LOC103794898
uniprot id: F7FTX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9483:CASQ1
gene id: 9483:CASQ1
uniprot id: A0A8I3WPH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9483:KPNB1
gene id: 9483:KPNB1
uniprot id: F7IN96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

9483:SLC11A1
gene id: 9483:SLC11A1
uniprot id: U3DZC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9483:GRK6
gene id: 9483:GRK6
uniprot id: F6QAF7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9483:EFS
gene id: 9483:EFS
uniprot id: U3DRH1
names: Similarity
messages: Belongs to the CAS family.

9483:CA9
gene id: 9483:CA9
uniprot id: F7I0J5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9483:POT1
gene id: 9483:POT1
uniprot id: F7FJ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9483:TFAP2B
gene id: 9483:TFAP2B
uniprot id: U3EVG1
names: Similarity
messages: Belongs to the AP-2 family.

9483:ADCYAP1
gene id: 9483:ADCYAP1
uniprot id: U3CGG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9483:SBNO1
gene id: 9483:SBNO1
uniprot id: F6Y413
uniprot id: U3BXS3
names: Similarity
messages: Belongs to the SBNO family.

9483:TSPAN31
gene id: 9483:TSPAN31
uniprot id: F7GXR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:H2AFV
gene id: 9483:H2AFV
uniprot id: A0A2R8P821
uniprot id: U3DUR7
uniprot id: U3EEU6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:MAF1
gene id: 9483:MAF1
uniprot id: U3DXM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

9483:ATP5F1E
gene id: 9483:ATP5F1E
uniprot id: F7GPK5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9483:ATF7IP
gene id: 9483:ATF7IP
uniprot id: F7ILH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9483:TM9SF1
gene id: 9483:TM9SF1
uniprot id: F6PMW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9483:KHDRBS1
gene id: 9483:KHDRBS1
uniprot id: U3DMI6
names: Similarity
messages: Belongs to the KHDRBS family.

9483:ADAT2
gene id: 9483:ADAT2
uniprot id: U3F1L5
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9483:ENKD1
gene id: 9483:ENKD1
uniprot id: F7HVV8
names: Subcellular Location Annotation
messages: cilium axoneme

9483:COQ4
gene id: 9483:COQ4
uniprot id: F6WM74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9483:MAPK8
gene id: 9483:MAPK8
uniprot id: A0A5K1UJA7
uniprot id: U3FKG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9483:ANXA7
gene id: 9483:ANXA7
uniprot id: F7DW50
uniprot id: F7EAB2
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9483:PARPBP
gene id: 9483:PARPBP
uniprot id: F7INL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9483:PGC
gene id: 9483:PGC
uniprot id: Q9N2D3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.
messages: Inhibited by pepstatin.
messages: Secreted

9483:LOC103789626
gene id: 9483:LOC103789626
uniprot id: F7GPI1
names: Similarity
messages: Belongs to the NOP10 family.

9483:DGCR2
gene id: 9483:DGCR2
uniprot id: U3F7U6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LITAF
gene id: 9483:LITAF
uniprot id: U3BJG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9483:NNMT
gene id: 9483:NNMT
uniprot id: F6T2K2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

9483:PSMB1
gene id: 9483:PSMB1
uniprot id: U3DT66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9483:TSNAX
gene id: 9483:TSNAX
uniprot id: F6TPC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9483:GPC6
gene id: 9483:GPC6
uniprot id: F7HKQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9483:PRSS36
gene id: 9483:PRSS36
uniprot id: F7I9U8
names: Function
names: Subcellular Location Annotation
messages: Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1.
messages: extracellular matrix

9483:DGAT2L6
gene id: 9483:DGAT2L6
uniprot id: F7IHM8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SDC1
gene id: 9483:SDC1
uniprot id: F7I933
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9483:RDH13
gene id: 9483:RDH13
uniprot id: A0A8I3VUZ7
uniprot id: U3D6L7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:TLE1
gene id: 9483:TLE1
uniprot id: A0A2R8N1C0
uniprot id: U3D0L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9483:HS3ST3A1
gene id: 9483:HS3ST3A1
uniprot id: F7IHW7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9483:DNAJA2
gene id: 9483:DNAJA2
uniprot id: F7HVJ2
names: Subcellular Location Annotation
messages: Membrane

9483:TOR1B
gene id: 9483:TOR1B
uniprot id: U3C1X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9483:BTBD10
gene id: 9483:BTBD10
uniprot id: A0A5F4WI75
uniprot id: A0A8I3VXR4
uniprot id: F6VL30
uniprot id: F7G7T7
names: Subcellular Location Annotation
messages: Cytoplasm

9483:SCOC
gene id: 9483:SCOC
uniprot id: F7GB77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

9483:ANP32B
gene id: 9483:ANP32B
uniprot id: F7ETK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9483:TAF6L
gene id: 9483:TAF6L
uniprot id: F7IFE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9483:ABI2
gene id: 9483:ABI2
uniprot id: F7EFN7
uniprot id: U3E8A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9483:CLTA
gene id: 9483:CLTA
uniprot id: F7CXQ1
uniprot id: F7DG30
uniprot id: F7E533
uniprot id: U3EBK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9483:DNAJC22
gene id: 9483:DNAJC22
uniprot id: F7ISX1
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9483:GK
gene id: 9483:GK
uniprot id: A0A5K1VG34
uniprot id: F7A4R7
uniprot id: U3D3V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9483:CDC123
gene id: 9483:CDC123
uniprot id: U3E0T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9483:NAAA
gene id: 9483:NAAA
uniprot id: A0A8I3W3F5
uniprot id: A0A8I3WJW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9483:LOC100408964
gene id: 9483:LOC100408964
uniprot id: A0A8I3XA00
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9483:PHAF1
gene id: 9483:PHAF1
uniprot id: F6UKG3
names: Similarity
messages: Belongs to the PHAF1 family.

9483:CUTA
gene id: 9483:CUTA
uniprot id: F7INQ1
uniprot id: U3D5W8
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9483:TICAM1
gene id: 9483:TICAM1
uniprot id: U3F0S9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.
messages: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
messages: Mitochondrion
messages: The N-terminal region is essential for activation of the IFNB promoter activity.
messages: autophagosome
messages: cytosol

9483:CD82
gene id: 9483:CD82
uniprot id: U3CCW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:GRM5
gene id: 9483:GRM5
uniprot id: U3F1K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9483:ALDH1A2
gene id: 9483:ALDH1A2
uniprot id: U3DC38
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:IMPDH1
gene id: 9483:IMPDH1
uniprot id: F7EBY6
uniprot id: F7EC54
uniprot id: U3FWE8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9483:RPP30
gene id: 9483:RPP30
uniprot id: U3FPZ8
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9483:MEIS1
gene id: 9483:MEIS1
uniprot id: F7HDM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9483:UBE2M
gene id: 9483:UBE2M
uniprot id: F7CFP7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:DCBLD2
gene id: 9483:DCBLD2
uniprot id: A0A5K1VHP5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:RAPGEF2
gene id: 9483:RAPGEF2
uniprot id: A0A2R8PKE4
uniprot id: U3DM90
names: Similarity
messages: Belongs to the RAPGEF2 family.

9483:LOC100401402
gene id: 9483:LOC100401402
uniprot id: U3FH16
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9483:GATAD2A
gene id: 9483:GATAD2A
uniprot id: A0A2R8MVD8
uniprot id: U3DIW8
names: Subcellular Location Annotation
messages: Nucleus

9483:HACL1
gene id: 9483:HACL1
uniprot id: U3BZ78
names: Similarity
messages: Belongs to the TPP enzyme family.

9483:ESS2
gene id: 9483:ESS2
uniprot id: U3CKQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9483:MRPS18C
gene id: 9483:MRPS18C
uniprot id: A0A8J8Y463
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

9483:ACTR1A
gene id: 9483:ACTR1A
uniprot id: U3CBW6
names: Similarity
messages: Belongs to the actin family.

9483:LYRM7
gene id: 9483:LYRM7
uniprot id: F7IQS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9483:PHTF2
gene id: 9483:PHTF2
uniprot id: F7I8N8
names: Subcellular Location Annotation
messages: Membrane

9483:HPSE2
gene id: 9483:HPSE2
uniprot id: U3BP05
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9483:DPYSL5
gene id: 9483:DPYSL5
uniprot id: F7I2B9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9483:LOC103792196
gene id: 9483:LOC103792196
uniprot id: A0A2R8MUI6
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:CLDN19
gene id: 9483:CLDN19
uniprot id: A0A2R8N099
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:BRINP3
gene id: 9483:BRINP3
uniprot id: F7I8S2
names: Similarity
messages: Belongs to the BRINP family.

9483:CELF1
gene id: 9483:CELF1
uniprot id: F6SMS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9483:PAQR3
gene id: 9483:PAQR3
uniprot id: F7GGE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9483:OR5I1
gene id: 9483:OR5I1
uniprot id: F7H5R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CENPN
gene id: 9483:CENPN
uniprot id: F6Z6E6
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9483:ETFA
gene id: 9483:ETFA
uniprot id: F7EF24
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9483:GSDME
gene id: 9483:GSDME
uniprot id: F7IGG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9483:STAT1
gene id: 9483:STAT1
uniprot id: A0A2R8P3H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9483:IMMP1L
gene id: 9483:IMMP1L
uniprot id: F7I6I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9483:TGFB1I1
gene id: 9483:TGFB1I1
uniprot id: A0A8I3WX24
uniprot id: F6WK60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.
messages: Nucleus matrix
messages: The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
messages: cytoskeleton
messages: focal adhesion

9483:OGDHL
gene id: 9483:OGDHL
uniprot id: A0A5K1VL13
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9483:CDADC1
gene id: 9483:CDADC1
uniprot id: U3E343
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9483:PIAS4
gene id: 9483:PIAS4
uniprot id: F7HES4
names: Similarity
messages: Belongs to the PIAS family.

9483:NCOA1
gene id: 9483:NCOA1
uniprot id: U3FP54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9483:ERRFI1
gene id: 9483:ERRFI1
uniprot id: F7H303
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9483:BARHL1
gene id: 9483:BARHL1
uniprot id: F6U1C3
names: Subcellular Location Annotation
messages: Nucleus

9483:FGF18
gene id: 9483:FGF18
uniprot id: A0A5F4WKI8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:LOC100396019
gene id: 9483:LOC100396019
uniprot id: A0A8I3X6D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:LOC103789858
gene id: 9483:LOC103789858
uniprot id: A0A5F4WFE7
names: Similarity
messages: Belongs to the STEEP1 family.

9483:XPOT
gene id: 9483:XPOT
uniprot id: U3EBE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9483:ANTXR2
gene id: 9483:ANTXR2
uniprot id: U3CH90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9483:ATE1
gene id: 9483:ATE1
uniprot id: F7IL39
uniprot id: F7INE2
uniprot id: U3BHG0
uniprot id: U3C0E3
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9483:CYP26A1
gene id: 9483:CYP26A1
uniprot id: F7A7M2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:HAPLN1
gene id: 9483:HAPLN1
uniprot id: F7GR30
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TELO2
gene id: 9483:TELO2
uniprot id: F6RHQ8
names: Similarity
messages: Belongs to the TEL2 family.

9483:PES1
gene id: 9483:PES1
uniprot id: U3AUB5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

9483:POP7
gene id: 9483:POP7
uniprot id: F7DTG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9483:SH3BGRL2
gene id: 9483:SH3BGRL2
uniprot id: F7DLV5
uniprot id: U3BEF5
names: Similarity
messages: Belongs to the SH3BGR family.

9483:ALG6
gene id: 9483:ALG6
uniprot id: U3BC09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:AURKA
gene id: 9483:AURKA
uniprot id: A0A8I3WN83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9483:P3H1
gene id: 9483:P3H1
uniprot id: F7IRA2
names: Similarity
messages: Belongs to the leprecan family.

9483:HNF4G
gene id: 9483:HNF4G
uniprot id: A0A8I3WG28
uniprot id: F6WNW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9483:MPPE1
gene id: 9483:MPPE1
uniprot id: U3ERB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9483:IL13RA1
gene id: 9483:IL13RA1
uniprot id: F7GLB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.
messages: Membrane

9483:IQCG
gene id: 9483:IQCG
uniprot id: F7CEK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

9483:LMNA
gene id: 9483:LMNA
uniprot id: U3FTJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9483:METAP1
gene id: 9483:METAP1
uniprot id: U3CAY5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9483:TATDN1
gene id: 9483:TATDN1
uniprot id: U3CPY9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9483:PIGV
gene id: 9483:PIGV
uniprot id: U3DAR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9483:DNAJC27
gene id: 9483:DNAJC27
uniprot id: F7ISW3
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9483:PAICS
gene id: 9483:PAICS
uniprot id: F6U4J5
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9483:CACNB2
gene id: 9483:CACNB2
uniprot id: U3CR85
uniprot id: U3CVV9
uniprot id: U3D197
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

9483:RMI1
gene id: 9483:RMI1
uniprot id: F6R6A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9483:PARVA
gene id: 9483:PARVA
uniprot id: A0A2R8MVK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: Membrane

9483:MPC2
gene id: 9483:MPC2
uniprot id: F7ICP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9483:CCR1
gene id: 9483:CCR1
uniprot id: Q9MYJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:NAA40
gene id: 9483:NAA40
uniprot id: F6TZV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

9483:PM20D2
gene id: 9483:PM20D2
uniprot id: F6XUF6
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.

9483:LOC103792211
gene id: 9483:LOC103792211
uniprot id: A0A8I3W029
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:SIX1
gene id: 9483:SIX1
uniprot id: U3E127
names: Subcellular Location Annotation
messages: Nucleus

9483:HMGN4
gene id: 9483:HMGN4
uniprot id: F7G9N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9483:LPAR2
gene id: 9483:LPAR2
uniprot id: U3DEU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:MARCKS
gene id: 9483:MARCKS
uniprot id: F7HYZ1
names: Similarity
messages: Belongs to the MARCKS family.

9483:DBT
gene id: 9483:DBT
uniprot id: U3CGC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9483:POLR2C
gene id: 9483:POLR2C
uniprot id: F6ZTF7
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9483:CETN1
gene id: 9483:CETN1
uniprot id: A0A8I3W2T6
names: Similarity
messages: Belongs to the centrin family.

9483:ZP3
gene id: 9483:ZP3
uniprot id: F7I9N9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9483:TTYH2
gene id: 9483:TTYH2
uniprot id: F7GUD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9483:HOXB5
gene id: 9483:HOXB5
uniprot id: F6ZUY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9483:CA14
gene id: 9483:CA14
uniprot id: F7IC13
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9483:MAN2B1
gene id: 9483:MAN2B1
uniprot id: U3ESG9
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9483:KCNF1
gene id: 9483:KCNF1
uniprot id: F7H006
names: Subcellular Location Annotation
messages: Membrane

9483:PGF
gene id: 9483:PGF
uniprot id: F7ITA1
uniprot id: U3BDP8
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9483:IL15
gene id: 9483:IL15
uniprot id: A0A2R8P5W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9483:DSCC1
gene id: 9483:DSCC1
uniprot id: F6YTT6
names: Similarity
messages: Belongs to the DCC1 family.

9483:DPP4
gene id: 9483:DPP4
uniprot id: F7IHU4
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9483:PCSK9
gene id: 9483:PCSK9
uniprot id: A8T688
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Cell surface
messages: Cleavage by furin and PCSK5 generates a truncated inactive protein that is unable to induce LDLR degradation.
messages: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Endosome
messages: Golgi apparatus
messages: Its proteolytic activity is autoinhibited by the non-covalent binding of the propeptide to the catalytic domain. Inhibited by EGTA (By similarity).
messages: Lysosome
messages: Monomer. Can self-associate to form dimers and higher multimers which may have increased LDLR degrading activity. The precursor protein but not the mature protein may form multimers. Interacts with APOB, VLDLR, LRP8/APOER2 and BACE1. The full-length immature form (pro-PCSK9) interacts with SCNN1A, SCNN1B and SCNN1G. The pro-PCSK9 form (via C-terminal domain) interacts with LDLR. Interacts (via the C-terminal domain) with ANXA2 (via repeat Annexin 1); the interaction inhibits the degradation of LDLR.
messages: Phosphorylation protects the propeptide against proteolysis.
messages: Secreted
messages: The C-terminal domain (CRD) is essential for the LDLR-binding and degrading activities.
messages: The catalytic domain is responsible for mediating its self-association.
messages: Undergoes autocatalytic cleavage in the endoplasmic reticulum to release the propeptide from the N-terminus and the cleavage of the propeptide is strictly required for its maturation and activation. The cleaved propeptide however remains associated with the catalytic domain through non-covalent interactions, preventing potential substrates from accessing its active site. As a result, it is secreted from cells as a propeptide-containing, enzymatically inactive protein (By similarity).

9483:MIX23
gene id: 9483:MIX23
uniprot id: F7GIH3
names: Similarity
messages: Belongs to the MIX23 family.

9483:CCNI
gene id: 9483:CCNI
uniprot id: U3F3I8
names: Similarity
messages: Belongs to the cyclin family.

9483:TECRL
gene id: 9483:TECRL
uniprot id: A0A5F4W8X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9483:FGF12
gene id: 9483:FGF12
uniprot id: A0A2R8NAI2
uniprot id: U3C9Y3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:ABCD3
gene id: 9483:ABCD3
uniprot id: A0A5F4W933
uniprot id: U3FKC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.
messages: Peroxisome membrane

9483:DPYSL3
gene id: 9483:DPYSL3
uniprot id: U3B2M3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9483:SLC7A1
gene id: 9483:SLC7A1
uniprot id: U3D7B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9483:VPS72
gene id: 9483:VPS72
uniprot id: U3BS67
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9483:IMPACT
gene id: 9483:IMPACT
uniprot id: U3DNP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

9483:TMEM134
gene id: 9483:TMEM134
uniprot id: F6YEZ0
uniprot id: F6YF44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

9483:ATP6V0A1
gene id: 9483:ATP6V0A1
uniprot id: U3CN61
uniprot id: U3FPA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9483:RPN1
gene id: 9483:RPN1
uniprot id: F7FXJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9483:PBX1
gene id: 9483:PBX1
uniprot id: F7IPP8
uniprot id: U3CS37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9483:MOSPD3
gene id: 9483:MOSPD3
uniprot id: F6XID8
names: Subcellular Location Annotation
messages: Membrane

9483:MT4
gene id: 9483:MT4
uniprot id: F7ISN0
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9483:GTF2E1
gene id: 9483:GTF2E1
uniprot id: U3EL39
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

9483:PRND
gene id: 9483:PRND
uniprot id: A0A2R8MKM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9483:TIMP3
gene id: 9483:TIMP3
uniprot id: B0KWT4
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9483:HPX
gene id: 9483:HPX
uniprot id: F7I2I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

9483:ZDHHC4
gene id: 9483:ZDHHC4
uniprot id: F6Z4M3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:GPHA2
gene id: 9483:GPHA2
uniprot id: U3DGG9
names: Caution
names: Similarity
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:NKIRAS2
gene id: 9483:NKIRAS2
uniprot id: F7GUH1
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9483:PPP2R2B
gene id: 9483:PPP2R2B
uniprot id: A0A8J8XP81
uniprot id: U3E8G8
uniprot id: U3ETB8
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9483:NFE2L3
gene id: 9483:NFE2L3
uniprot id: A0A8I3WK70
uniprot id: F7I4F2
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9483:COQ10A
gene id: 9483:COQ10A
uniprot id: F7EC97
uniprot id: F7EQA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9483:IPMK
gene id: 9483:IPMK
uniprot id: F6SSU3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9483:OTUB1
gene id: 9483:OTUB1
uniprot id: F6QN11
names: Similarity
messages: Belongs to the peptidase C65 family.

9483:ASB4
gene id: 9483:ASB4
uniprot id: F7GMS4
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:ANO10
gene id: 9483:ANO10
uniprot id: A0A5F4W8J9
uniprot id: A0A5F4WEL5
uniprot id: U3DKS8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SLC5A8
gene id: 9483:SLC5A8
uniprot id: A0A5F4WFU2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9483:TTC4
gene id: 9483:TTC4
uniprot id: U3DS20
names: Similarity
messages: Belongs to the TTC4 family.

9483:PAPSS2
gene id: 9483:PAPSS2
uniprot id: F7F717
uniprot id: F7FL78
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9483:PPIE
gene id: 9483:PPIE
uniprot id: U3FEP0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

9483:PPP1R12B
gene id: 9483:PPP1R12B
uniprot id: U3CCN1
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9483:NEK9
gene id: 9483:NEK9
uniprot id: F7I9E1
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9483:NXF1
gene id: 9483:NXF1
uniprot id: U3DVC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9483:TCTA
gene id: 9483:TCTA
uniprot id: A0A8I3X618
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9483:CNTNAP5
gene id: 9483:CNTNAP5
uniprot id: A0A8J8XTB1
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:VEGFD
gene id: 9483:VEGFD
uniprot id: F6VG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9483:COQ9
gene id: 9483:COQ9
uniprot id: F6YBA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9483:SOAT1
gene id: 9483:SOAT1
uniprot id: F7FD82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:WLS
gene id: 9483:WLS
uniprot id: U3FL96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9483:NEU1
gene id: 9483:NEU1
uniprot id: F6YMA5
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9483:IKBKE
gene id: 9483:IKBKE
uniprot id: F7IAT5
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ATG101
gene id: 9483:ATG101
uniprot id: F6SXY0
names: Similarity
messages: Belongs to the ATG101 family.

9483:HS3ST3B1
gene id: 9483:HS3ST3B1
uniprot id: A0A2R8PMI3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9483:ACSL5
gene id: 9483:ACSL5
uniprot id: A0A8I4A221
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9483:INTS12
gene id: 9483:INTS12
uniprot id: F7HYK4
names: Similarity
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

9483:ATP6V1D
gene id: 9483:ATP6V1D
uniprot id: U3D2W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9483:GLYATL3
gene id: 9483:GLYATL3
uniprot id: A0A8I4A4R1
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9483:SLAIN2
gene id: 9483:SLAIN2
uniprot id: A0A2R8M343
uniprot id: U3BI85
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9483:OSBPL11
gene id: 9483:OSBPL11
uniprot id: F6U8U2
names: Similarity
messages: Belongs to the OSBP family.

9483:SCRN3
gene id: 9483:SCRN3
uniprot id: F7HV39
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9483:SMC1A
gene id: 9483:SMC1A
uniprot id: F7IDJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9483:MCOLN2
gene id: 9483:MCOLN2
uniprot id: F6TMD9
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9483:MAGOHB
gene id: 9483:MAGOHB
uniprot id: F7I061
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9483:CSF2
gene id: 9483:CSF2
uniprot id: B0KWQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9483:TMEM129
gene id: 9483:TMEM129
uniprot id: F7GUY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9483:NFKB1
gene id: 9483:NFKB1
uniprot id: F6V7I0
uniprot id: U3FK78
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:FLVCR2
gene id: 9483:FLVCR2
uniprot id: F7HXI9
uniprot id: F7HXJ4
names: Subcellular Location Annotation
messages: Membrane

9483:PLAUR
gene id: 9483:PLAUR
uniprot id: F6QVF1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:ADORA3
gene id: 9483:ADORA3
uniprot id: U3DWN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9483:LOC100404734
gene id: 9483:LOC100404734
uniprot id: A0A8I3WI83
names: Similarity
messages: Belongs to the cystatin family.

9483:LZIC
gene id: 9483:LZIC
uniprot id: F7BV86
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9483:SUV39H2
gene id: 9483:SUV39H2
uniprot id: F7AGB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

9483:COQ8A
gene id: 9483:COQ8A
uniprot id: F7GNJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane

9483:DMRT3
gene id: 9483:DMRT3
uniprot id: A0A5F4VV30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9483:FAM167B
gene id: 9483:FAM167B
uniprot id: F6QAE5
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9483:ESYT3
gene id: 9483:ESYT3
uniprot id: U3B9Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:CDC25A
gene id: 9483:CDC25A
uniprot id: F6UZN3
uniprot id: F6UZV6
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9483:SCARB2
gene id: 9483:SCARB2
uniprot id: U3F7N9
names: Similarity
messages: Belongs to the CD36 family.

9483:GSS
gene id: 9483:GSS
uniprot id: Q1HGK4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9483:PITX1
gene id: 9483:PITX1
uniprot id: F7HTS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9483:LOC108593219
gene id: 9483:LOC108593219
uniprot id: U3EIA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9483:CSTF1
gene id: 9483:CSTF1
uniprot id: F7GJ78
names: Subcellular Location Annotation
messages: Nucleus

9483:TRIM39
gene id: 9483:TRIM39
uniprot id: U3CT43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:XIAP
gene id: 9483:XIAP
uniprot id: B0KWH9
names: Similarity
messages: Belongs to the IAP family.

9483:SYS1
gene id: 9483:SYS1
uniprot id: U3ECS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9483:CALHM1
gene id: 9483:CALHM1
uniprot id: F6QMY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9483:LOC100395465
gene id: 9483:LOC100395465
uniprot id: B0KWS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9483:NIPSNAP1
gene id: 9483:NIPSNAP1
uniprot id: F7IGZ2
names: Similarity
messages: Belongs to the NipSnap family.

9483:MRPL1
gene id: 9483:MRPL1
uniprot id: U3D3C9
names: Subcellular Location Annotation
messages: Mitochondrion

9483:PTPN1
gene id: 9483:PTPN1
uniprot id: F6SC52
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9483:CDKL1
gene id: 9483:CDKL1
uniprot id: F7GM77
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:SLC25A43
gene id: 9483:SLC25A43
uniprot id: A0A8J8YHB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:VPS35
gene id: 9483:VPS35
uniprot id: F7H0E8
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9483:HPS3
gene id: 9483:HPS3
uniprot id: U3E815
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9483:ACER3
gene id: 9483:ACER3
uniprot id: F6XIB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9483:ESR2
gene id: 9483:ESR2
uniprot id: Q95ME9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9483:GH1P6
gene id: 9483:GH1P6
uniprot id: Q8MI74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9483:ING2
gene id: 9483:ING2
uniprot id: F6V9W3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9483:TMEM14C
gene id: 9483:TMEM14C
uniprot id: U3BQG5
names: Similarity
messages: Belongs to the TMEM14 family.

9483:LOC103794477
gene id: 9483:LOC103794477
uniprot id: F6VGW5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

9483:EDA
gene id: 9483:EDA
uniprot id: A0A0U5J5L9
uniprot id: A0A2R8N1B1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:LOC100395855
gene id: 9483:LOC100395855
uniprot id: F7DWR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9483:CCR2
gene id: 9483:CCR2
uniprot id: F7DT70
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:ATP2B4
gene id: 9483:ATP2B4
uniprot id: A0A8I3WUW2
uniprot id: U3CQA9
uniprot id: U3D6X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:LOC100400179
gene id: 9483:LOC100400179
uniprot id: F7HC29
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:RPL14
gene id: 9483:RPL14
uniprot id: F6PLX7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9483:OSBPL8
gene id: 9483:OSBPL8
uniprot id: F7ADF6
names: Similarity
messages: Belongs to the OSBP family.

9483:PSME2
gene id: 9483:PSME2
uniprot id: U3CVT8
names: Similarity
messages: Belongs to the PA28 family.

9483:FPR3
gene id: 9483:FPR3
uniprot id: A0A2R8N2M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9483:LOC108589472
gene id: 9483:LOC108589472
uniprot id: B0VXF6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:CFDP1
gene id: 9483:CFDP1
uniprot id: F7IQY8
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

9483:AHCY
gene id: 9483:AHCY
uniprot id: U3ED98
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9483:CCT8
gene id: 9483:CCT8
uniprot id: A0A8I3WX76
uniprot id: U3BFL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

9483:EIF3F
gene id: 9483:EIF3F
uniprot id: F6PQN1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9483:COX4I2
gene id: 9483:COX4I2
uniprot id: F7IT30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9483:ERCC4
gene id: 9483:ERCC4
uniprot id: F7HLG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9483:LCORL
gene id: 9483:LCORL
uniprot id: A0A8I3X4R7
names: Subcellular Location Annotation
messages: Nucleus

9483:RNPS1
gene id: 9483:RNPS1
uniprot id: F7CTQ3
uniprot id: F7CTS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
messages: Nucleus speckle

9483:ANP32A
gene id: 9483:ANP32A
uniprot id: F7C9V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Multifunctional protein that is involved in the regulation of many processes.
messages: Nucleus

9483:TMEM97
gene id: 9483:TMEM97
uniprot id: F7IFA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM97/sigma-2 receptor family.
messages: Endoplasmic reticulum membrane
messages: Interacts with NPC1.
messages: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

9483:SGK3
gene id: 9483:SGK3
uniprot id: F7I8H6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9483:LOC100402677
gene id: 9483:LOC100402677
uniprot id: A0A2R8N908
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:LYNX1
gene id: 9483:LYNX1
uniprot id: F7H437
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:EDN1
gene id: 9483:EDN1
uniprot id: F7H803
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9483:MYG1
gene id: 9483:MYG1
uniprot id: F6ZS88
names: Similarity
messages: Belongs to the MYG1 family.

9483:RBM48
gene id: 9483:RBM48
uniprot id: U3DXH7
names: Function
names: Similarity
names: Subunit
messages: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: Belongs to the RBM48 family.
messages: Component of the minor spliceosome. Within this complex, interacts with ARMC7 and PRPF8/PRP8.

9483:TUBB6
gene id: 9483:TUBB6
uniprot id: F7BBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9483:RAD52
gene id: 9483:RAD52
uniprot id: U3D250
names: Similarity
messages: Belongs to the RAD52 family.

9483:LDHD
gene id: 9483:LDHD
uniprot id: F7HV82
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9483:CYP26C1
gene id: 9483:CYP26C1
uniprot id: F7C6P2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:ASB5
gene id: 9483:ASB5
uniprot id: A0A8I3X0U2
uniprot id: U3DCC2
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:GABRR3
gene id: 9483:GABRR3
uniprot id: F7H4P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:SEC11A
gene id: 9483:SEC11A
uniprot id: A0A8J8YEM9
uniprot id: U3F5P8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:CLPP
gene id: 9483:CLPP
uniprot id: U3DUU6
names: Similarity
messages: Belongs to the peptidase S14 family.

9483:TRAF5
gene id: 9483:TRAF5
uniprot id: U3DJM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9483:LOC100403703
gene id: 9483:LOC100403703
uniprot id: U3E603
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: cytosol

9483:TMEM19
gene id: 9483:TMEM19
uniprot id: A0A8I4A1H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9483:AMBP
gene id: 9483:AMBP
uniprot id: F6R1P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9483:VPS11
gene id: 9483:VPS11
uniprot id: U3C3H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9483:RASSF5
gene id: 9483:RASSF5
uniprot id: F7IMG6
names: Subcellular Location Annotation
messages: cytoskeleton

9483:TBXAS1
gene id: 9483:TBXAS1
uniprot id: U3DSB5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:TNFRSF19
gene id: 9483:TNFRSF19
uniprot id: F7I198
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CAST
gene id: 9483:CAST
uniprot id: A0A5F4W7D5
uniprot id: F7GIP0
uniprot id: F7GLR8
uniprot id: F7GQ91
uniprot id: F7GQ96
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9483:LOC100401098
gene id: 9483:LOC100401098
uniprot id: F7HBV1
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9483:LAPTM5
gene id: 9483:LAPTM5
uniprot id: F7I1A8
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9483:SESN1
gene id: 9483:SESN1
uniprot id: F7HTE0
uniprot id: U3BTQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9483:NOL10
gene id: 9483:NOL10
uniprot id: U3DJD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9483:FGF1
gene id: 9483:FGF1
uniprot id: B0KW92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9483:YWHAH
gene id: 9483:YWHAH
uniprot id: B0KWS1
names: Similarity
messages: Belongs to the 14-3-3 family.

9483:TPRG1L
gene id: 9483:TPRG1L
uniprot id: U3DY61
names: Similarity
messages: Belongs to the TPRG1 family.

9483:CALCRL
gene id: 9483:CALCRL
uniprot id: F6YRQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9483:SMG5
gene id: 9483:SMG5
uniprot id: F7ID90
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

9483:CYP2E1
gene id: 9483:CYP2E1
uniprot id: Q6LEM3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Membrane
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9483:KPNA6
gene id: 9483:KPNA6
uniprot id: F7FPD9
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9483:FXYD6
gene id: 9483:FXYD6
uniprot id: F7FL84
names: Similarity
messages: Belongs to the FXYD family.

9483:RBM3
gene id: 9483:RBM3
uniprot id: U3EBH3
names: Subcellular Location Annotation
messages: Cytoplasm

9483:SERPINB10
gene id: 9483:SERPINB10
uniprot id: B0CMB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity).

9483:ARF1
gene id: 9483:ARF1
uniprot id: F6W8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9483:MTAP
gene id: 9483:MTAP
uniprot id: F7I6R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9483:SSR3
gene id: 9483:SSR3
uniprot id: F7IFI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9483:STARD13
gene id: 9483:STARD13
uniprot id: A0A8I3WG93
uniprot id: F6ZB18
uniprot id: U3D8C2
names: Subcellular Location Annotation
messages: Cytoplasm

9483:PRKRIP1
gene id: 9483:PRKRIP1
uniprot id: F7I545
names: Similarity
messages: Belongs to the PRKRIP1 family.

9483:CUZD1
gene id: 9483:CUZD1
uniprot id: F6X244
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:BLOC1S6
gene id: 9483:BLOC1S6
uniprot id: A0A2R8MPZ9
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9483:ZNF706
gene id: 9483:ZNF706
uniprot id: F7HSE6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:DNM1L
gene id: 9483:DNM1L
uniprot id: A0A2R8MVS5
uniprot id: F6SIE1
uniprot id: F6TQ78
uniprot id: F6U0L1
uniprot id: U3BXM6
uniprot id: U3FH93
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9483:CTNNAL1
gene id: 9483:CTNNAL1
uniprot id: F7I0U2
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9483:USP15
gene id: 9483:USP15
uniprot id: F7F8G3
uniprot id: F7FM26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9483:UBXN1
gene id: 9483:UBXN1
uniprot id: F7IK28
names: Subcellular Location Annotation
messages: Cytoplasm

9483:CDK5RAP2
gene id: 9483:CDK5RAP2
uniprot id: F6ZC98
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: centrosome

9483:SUPT6H
gene id: 9483:SUPT6H
uniprot id: U3D391
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9483:LIF
gene id: 9483:LIF
uniprot id: F7GQ12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

9483:MTX1
gene id: 9483:MTX1
uniprot id: U3D2E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:RELT
gene id: 9483:RELT
uniprot id: F7I7U0
names: Similarity
messages: Belongs to the RELT family.

9483:TNFRSF11B
gene id: 9483:TNFRSF11B
uniprot id: F7HTR5
names: Caution
names: Function
names: Subunit
messages: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CLDN18
gene id: 9483:CLDN18
uniprot id: A0A2R8M8V8
uniprot id: F6WTG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9483:LOC100406056
gene id: 9483:LOC100406056
uniprot id: A0A5F4VVT1
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9483:UBE3A
gene id: 9483:UBE3A
uniprot id: A0A2R8N2Q5
uniprot id: U3EB97
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9483:PSME4
gene id: 9483:PSME4
uniprot id: A0A8I3VY39
uniprot id: F7A030
uniprot id: U3BKW6
names: Similarity
messages: Belongs to the BLM10 family.

9483:CATSPERE
gene id: 9483:CATSPERE
uniprot id: F7HLX8
names: Similarity
messages: Belongs to the CATSPERD family.

9483:SCARF1
gene id: 9483:SCARF1
uniprot id: U3CRP6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SLC39A4
gene id: 9483:SLC39A4
uniprot id: A0A2R8MGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9483:RER1
gene id: 9483:RER1
uniprot id: U3DIV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9483:USP20
gene id: 9483:USP20
uniprot id: U3CPF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9483:ALDH8A1
gene id: 9483:ALDH8A1
uniprot id: F7HZS8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:COPS8
gene id: 9483:COPS8
uniprot id: F6TJS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9483:LOXL2
gene id: 9483:LOXL2
uniprot id: U3D6J6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9483:AHCYL1
gene id: 9483:AHCYL1
uniprot id: U3DDT1
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9483:EMC4
gene id: 9483:EMC4
uniprot id: F7EN63
uniprot id: F7EN65
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:BTG2
gene id: 9483:BTG2
uniprot id: F7H971
names: Similarity
messages: Belongs to the BTG family.

9483:SERPINB7
gene id: 9483:SERPINB7
uniprot id: B0CMA8
names: Similarity
messages: Belongs to the serpin family.

9483:NKX6-1
gene id: 9483:NKX6-1
uniprot id: F7GWX6
names: Subcellular Location Annotation
messages: Nucleus

9483:MADD
gene id: 9483:MADD
uniprot id: F7E459
uniprot id: F7GT09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9483:PARK7
gene id: 9483:PARK7
uniprot id: F7H340
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9483:TNFSF13B
gene id: 9483:TNFSF13B
uniprot id: F7FUZ6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:LOC100413404
gene id: 9483:LOC100413404
uniprot id: A0A6G6XEG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9483:GNGT1
gene id: 9483:GNGT1
uniprot id: F6WMN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:CAPZA1
gene id: 9483:CAPZA1
uniprot id: A0A2R8MC54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9483:CYB5R1
gene id: 9483:CYB5R1
uniprot id: F7I687
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9483:MON1A
gene id: 9483:MON1A
uniprot id: F7HTY3
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9483:NHERF1
gene id: 9483:NHERF1
uniprot id: F7FEW8
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

9483:NEK7
gene id: 9483:NEK7
uniprot id: U3FJS7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:LOC100400246
gene id: 9483:LOC100400246
uniprot id: F7I8N6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:LOC100394153
gene id: 9483:LOC100394153
uniprot id: A0A8I4A5V8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9483:TOP3B
gene id: 9483:TOP3B
uniprot id: F7ADD1
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9483:LTA
gene id: 9483:LTA
uniprot id: A0A0U5JA93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9483:GPAT3
gene id: 9483:GPAT3
uniprot id: U3D170
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9483:CRYL1
gene id: 9483:CRYL1
uniprot id: F7HM70
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9483:STMN3
gene id: 9483:STMN3
uniprot id: U3DU69
names: Similarity
messages: Belongs to the stathmin family.

9483:HAL
gene id: 9483:HAL
uniprot id: F6YL38
names: Similarity
messages: Belongs to the PAL/histidase family.

9483:IMPG1
gene id: 9483:IMPG1
uniprot id: F6SRM0
names: Subcellular Location Annotation
messages: interphotoreceptor matrix

9483:EIF3H
gene id: 9483:EIF3H
uniprot id: U3CCN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9483:ATG4D
gene id: 9483:ATG4D
uniprot id: F7D851
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9483:RBKS
gene id: 9483:RBKS
uniprot id: F7H3K8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9483:USP49
gene id: 9483:USP49
uniprot id: B0KWN4
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:SPG21
gene id: 9483:SPG21
uniprot id: U3DFP9
names: Function
names: Subunit
messages: Interacts with CD4. Interacts with ALDH16A1.
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9483:NPY1R
gene id: 9483:NPY1R
uniprot id: F7I5Y1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:ZFPM2
gene id: 9483:ZFPM2
uniprot id: A0A5F4VRF0
uniprot id: A0A8I3WFX5
names: Subcellular Location Annotation
messages: Nucleus

9483:FUT2
gene id: 9483:FUT2
uniprot id: F7HA38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a.
messages: Golgi stack membrane
messages: Membrane

9483:PIK3C3
gene id: 9483:PIK3C3
uniprot id: U3DFJ6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9483:S100A1
gene id: 9483:S100A1
uniprot id: U3D200
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Mitochondrion

9483:GPR39
gene id: 9483:GPR39
uniprot id: U3DHX8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:KCND2
gene id: 9483:KCND2
uniprot id: U3CD42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9483:PIP4P2
gene id: 9483:PIP4P2
uniprot id: A0A5F4WMQ6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9483:ARMCX3
gene id: 9483:ARMCX3
uniprot id: F7GD88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9483:AGO2
gene id: 9483:AGO2
uniprot id: A0A8I3XET5
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity.
messages: Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1. Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA-and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA. Interacts with TRIM71. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with FMR1. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
messages: The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).

9483:SENP6
gene id: 9483:SENP6
uniprot id: U3DNX7
uniprot id: U3F906
names: Similarity
messages: Belongs to the peptidase C48 family.

9483:PDP2
gene id: 9483:PDP2
uniprot id: F6WMA3
names: Similarity
messages: Belongs to the PP2C family.

9483:IL4R
gene id: 9483:IL4R
uniprot id: Q0PIT7
names: Function
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

9483:LOC100414193
gene id: 9483:LOC100414193
uniprot id: B0VXC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC103796238
gene id: 9483:LOC103796238
uniprot id: A0A8I3WLV8
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9483:PDCD5
gene id: 9483:PDCD5
uniprot id: F6YB48
names: Similarity
messages: Belongs to the PDCD5 family.

9483:UFM1
gene id: 9483:UFM1
uniprot id: U3DH81
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9483:IL2RG
gene id: 9483:IL2RG
uniprot id: A5HJL6
names: Subcellular Location Annotation
messages: Membrane

9483:MEOX1
gene id: 9483:MEOX1
uniprot id: A0A8I3WWZ6
names: Subcellular Location Annotation
messages: Nucleus

9483:CGA
gene id: 9483:CGA
uniprot id: A0A5K1VJ21
uniprot id: P51499
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9483:PIM2
gene id: 9483:PIM2
uniprot id: F7C4B8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9483:NUDT18
gene id: 9483:NUDT18
uniprot id: F6ZVD3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9483:RPRD1B
gene id: 9483:RPRD1B
uniprot id: F7IJC6
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9483:HESX1
gene id: 9483:HESX1
uniprot id: F7E187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

9483:RRP7A
gene id: 9483:RRP7A
uniprot id: U3BYA6
names: Similarity
messages: Belongs to the RRP7 family.

9483:FICD
gene id: 9483:FICD
uniprot id: U3D3E3
names: Similarity
messages: Belongs to the fic family.

9483:ZAR1L
gene id: 9483:ZAR1L
uniprot id: F7BC83
names: Similarity
names: Subunit
messages: Belongs to the ZAR1 family.
messages: Interacts with YBX2.

9483:TMPRSS2
gene id: 9483:TMPRSS2
uniprot id: F7H6E7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ACTL6A
gene id: 9483:ACTL6A
uniprot id: U3C2I1
names: Similarity
messages: Belongs to the actin family.

9483:MMACHC
gene id: 9483:MMACHC
uniprot id: U3E275
names: Similarity
messages: Belongs to the MMACHC family.

9483:LOC100393374
gene id: 9483:LOC100393374
uniprot id: F7BEV5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9483:GINS4
gene id: 9483:GINS4
uniprot id: U3DIB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9483:MRPS9
gene id: 9483:MRPS9
uniprot id: U3DD41
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9483:SMC2
gene id: 9483:SMC2
uniprot id: U3BGS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

9483:LOC100395175
gene id: 9483:LOC100395175
uniprot id: F7IDZ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:CLIC4
gene id: 9483:CLIC4
uniprot id: F7EXF2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9483:MEGF11
gene id: 9483:MEGF11
uniprot id: F6VXR6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:APLP1
gene id: 9483:APLP1
uniprot id: A0A5K1UW72
uniprot id: F7DJJ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:MRPS33
gene id: 9483:MRPS33
uniprot id: F6QIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9483:SLC43A3
gene id: 9483:SLC43A3
uniprot id: F7C5I5
names: Subcellular Location Annotation
messages: Membrane

9483:VDAC2
gene id: 9483:VDAC2
uniprot id: U3BRF6
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9483:ATP6V1B2
gene id: 9483:ATP6V1B2
uniprot id: A0A2R8MBE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9483:PRPF4B
gene id: 9483:PRPF4B
uniprot id: F7GNQ7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

9483:MIF
gene id: 9483:MIF
uniprot id: H9KWP1
names: Similarity
messages: Belongs to the MIF family.

9483:USP1
gene id: 9483:USP1
uniprot id: F7HWE7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:LOC100386370
gene id: 9483:LOC100386370
uniprot id: F7HAW6
names: Subcellular Location Annotation
messages: Membrane

9483:SMIM19
gene id: 9483:SMIM19
uniprot id: F7FD34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9483:GLIPR1
gene id: 9483:GLIPR1
uniprot id: U3CWN0
names: Similarity
messages: Belongs to the CRISP family.

9483:ADGRG3
gene id: 9483:ADGRG3
uniprot id: F6QY45
names: Subcellular Location Annotation
messages: Membrane

9483:SLC25A1
gene id: 9483:SLC25A1
uniprot id: U3EX65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:PPP4R3C
gene id: 9483:PPP4R3C
uniprot id: F7BFK1
names: Similarity
messages: Belongs to the SMEK family.

9483:LOC100415550
gene id: 9483:LOC100415550
uniprot id: A0A8I3W2Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9483:VIPR2
gene id: 9483:VIPR2
uniprot id: F6XPH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9483:RRAGC
gene id: 9483:RRAGC
uniprot id: F6WBJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9483:GNG11
gene id: 9483:GNG11
uniprot id: F6X977
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:USB1
gene id: 9483:USB1
uniprot id: F6TF64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9483:CDK2AP1
gene id: 9483:CDK2AP1
uniprot id: A0A8I3W4M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9483:NDUFS3
gene id: 9483:NDUFS3
uniprot id: F6VZL4
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

9483:LOC100390706
gene id: 9483:LOC100390706
uniprot id: A0A8I3VWL0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:EFEMP1
gene id: 9483:EFEMP1
uniprot id: F7B2A3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:BOLA2B
gene id: 9483:BOLA2B
uniprot id: F7D8D9
names: Similarity
messages: Belongs to the BolA/IbaG family.

9483:MCPH1
gene id: 9483:MCPH1
uniprot id: A0A8I3W9V5
uniprot id: A0A8I3WU68
uniprot id: U3EH78
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

9483:ARPC1A
gene id: 9483:ARPC1A
uniprot id: U3FEQ0
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9483:ACTL9
gene id: 9483:ACTL9
uniprot id: F7FGP2
names: Similarity
messages: Belongs to the actin family.

9483:LOC100412636
gene id: 9483:LOC100412636
uniprot id: A0A5F4WMT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:IRGQ
gene id: 9483:IRGQ
uniprot id: U3CLC6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9483:STRN3
gene id: 9483:STRN3
uniprot id: F7I8F1
uniprot id: U3FCL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9483:STRADA
gene id: 9483:STRADA
uniprot id: A0A2R8PI98
uniprot id: F6TYM5
uniprot id: U3CSP5
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9483:C2H5orf63
gene id: 9483:C2H5orf63
uniprot id: F7E4F2
names: Similarity
messages: Belongs to the glutaredoxin family.

9483:TNFSF15
gene id: 9483:TNFSF15
uniprot id: A0A0U5J7D7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:DERL2
gene id: 9483:DERL2
uniprot id: U3CUW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:LOC100390305
gene id: 9483:LOC100390305
uniprot id: A0A2R8MA88
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9483:MTMR3
gene id: 9483:MTMR3
uniprot id: U3FL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9483:PVALB
gene id: 9483:PVALB
uniprot id: F6ZWB4
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9483:CHST14
gene id: 9483:CHST14
uniprot id: F7FE82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:DOK5
gene id: 9483:DOK5
uniprot id: F7BN10
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9483:POLR2F
gene id: 9483:POLR2F
uniprot id: F7HWV2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9483:FER
gene id: 9483:FER
uniprot id: A0A8I3WXR3
uniprot id: U3C8J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9483:SLITRK3
gene id: 9483:SLITRK3
uniprot id: F7IJP7
names: Similarity
messages: Belongs to the SLITRK family.

9483:CORO6
gene id: 9483:CORO6
uniprot id: F7CGH9
uniprot id: U3EM49
names: Similarity
messages: Belongs to the WD repeat coronin family.

9483:NXPE3
gene id: 9483:NXPE3
uniprot id: U3DW86
names: Similarity
messages: Belongs to the NXPE family.

9483:C6H2orf88
gene id: 9483:C6H2orf88
uniprot id: F7HZ56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9483:LOC100412476
gene id: 9483:LOC100412476
uniprot id: O77570
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9483:STX16
gene id: 9483:STX16
uniprot id: U3DL97
uniprot id: U3FTM0
names: Similarity
messages: Belongs to the syntaxin family.

9483:GPR137B
gene id: 9483:GPR137B
uniprot id: F6TJ23
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9483:CCDC93
gene id: 9483:CCDC93
uniprot id: B0CMA3
names: Similarity
messages: Belongs to the CCDC93 family.

9483:TXNIP
gene id: 9483:TXNIP
uniprot id: F7GFR5
names: Similarity
messages: Belongs to the arrestin family.

9483:HSD17B10
gene id: 9483:HSD17B10
uniprot id: U3D1B8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:MYO10
gene id: 9483:MYO10
uniprot id: A0A8I4A4S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

9483:TERF2IP
gene id: 9483:TERF2IP
uniprot id: F7IEA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9483:SLC10A3
gene id: 9483:SLC10A3
uniprot id: B0KWT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9483:HCCS
gene id: 9483:HCCS
uniprot id: F6XSM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9483:RRAGB
gene id: 9483:RRAGB
uniprot id: F7BFD1
uniprot id: F7BGE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9483:LOC100401718
gene id: 9483:LOC100401718
uniprot id: F7AI40
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9483:SIX2
gene id: 9483:SIX2
uniprot id: F6Z031
names: Subcellular Location Annotation
messages: Nucleus

9483:PSMC1
gene id: 9483:PSMC1
uniprot id: F7DZ95
names: Similarity
messages: Belongs to the AAA ATPase family.

9483:TLR7
gene id: 9483:TLR7
uniprot id: F6S8L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9483:PPP2R2C
gene id: 9483:PPP2R2C
uniprot id: A0A2R8MBU1
uniprot id: F7HRR7
uniprot id: U3EWR4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9483:ST6GALNAC5
gene id: 9483:ST6GALNAC5
uniprot id: U3CCQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:SNCA
gene id: 9483:SNCA
uniprot id: F7GY62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

9483:DHX9
gene id: 9483:DHX9
uniprot id: U3CWY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9483:LOC100395495
gene id: 9483:LOC100395495
uniprot id: F7DWQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Odorant receptor.

9483:TFEC
gene id: 9483:TFEC
uniprot id: A0A2R8MDP8
uniprot id: A0A2R8MPG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9483:LOC100398433
gene id: 9483:LOC100398433
uniprot id: F7IHC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9483:KCNK16
gene id: 9483:KCNK16
uniprot id: F7HMK7
uniprot id: F7HTD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9483:ATG12
gene id: 9483:ATG12
uniprot id: U3ER96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9483:ASTL
gene id: 9483:ASTL
uniprot id: F7IPR9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:RHAG
gene id: 9483:RHAG
uniprot id: F6TSA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9483:RAB27B
gene id: 9483:RAB27B
uniprot id: U3D1S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9483:POP4
gene id: 9483:POP4
uniprot id: A0A2R8MIN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9483:PLAU
gene id: 9483:PLAU
uniprot id: U3D503
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ADAM19
gene id: 9483:ADAM19
uniprot id: U3FXS6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:LOC108594116
gene id: 9483:LOC108594116
uniprot id: F7IHV9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:RCAN1
gene id: 9483:RCAN1
uniprot id: F7ICJ9
uniprot id: F7ICK3
names: Similarity
messages: Belongs to the RCAN family.

9483:COMT
gene id: 9483:COMT
uniprot id: U3CQ46
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
messages: Cell membrane

9483:NMNAT2
gene id: 9483:NMNAT2
uniprot id: U3CKG7
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9483:INPP1
gene id: 9483:INPP1
uniprot id: F7ISD4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9483:LCA5
gene id: 9483:LCA5
uniprot id: F7E2G3
names: Similarity
messages: Belongs to the LCA5 family.

9483:IGF2BP3
gene id: 9483:IGF2BP3
uniprot id: F7HZQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9483:DUSP16
gene id: 9483:DUSP16
uniprot id: F7IJ42
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9483:C5H17orf62
gene id: 9483:C5H17orf62
uniprot id: A0A2R8N184
uniprot id: F6SWT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:FOXJ2
gene id: 9483:FOXJ2
uniprot id: U3FLZ1
names: Subcellular Location Annotation
messages: Nucleus

9483:TDRD7
gene id: 9483:TDRD7
uniprot id: F7HUL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

9483:GPNMB
gene id: 9483:GPNMB
uniprot id: F7I265
names: Similarity
messages: Belongs to the PMEL/NMB family.

9483:LOC100413757
gene id: 9483:LOC100413757
uniprot id: F7DXF3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

9483:ATAD1
gene id: 9483:ATAD1
uniprot id: U3FN99
names: Similarity
messages: Belongs to the AAA ATPase family.

9483:LOC100395124
gene id: 9483:LOC100395124
uniprot id: F6R1Q9
names: Similarity
messages: Belongs to the intermediate filament family.

9483:TFR2
gene id: 9483:TFR2
uniprot id: F7H9B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9483:CD3D
gene id: 9483:CD3D
uniprot id: F7FPX1
names: Subcellular Location Annotation
messages: Membrane

9483:PRKN
gene id: 9483:PRKN
uniprot id: U3FQA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. Parkin subfamily.
messages: Forms an E3 ubiquitin ligase complex.
messages: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
messages: Mitochondrion
messages: cytosol

9483:HARS2
gene id: 9483:HARS2
uniprot id: F7I7A3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9483:KCNJ6
gene id: 9483:KCNJ6
uniprot id: F7BNG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9483:OSBPL7
gene id: 9483:OSBPL7
uniprot id: F7I772
uniprot id: U3BMZ8
names: Similarity
messages: Belongs to the OSBP family.

9483:TMEM59
gene id: 9483:TMEM59
uniprot id: F7I1M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:ITM2B
gene id: 9483:ITM2B
uniprot id: U3EHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9483:MDH2
gene id: 9483:MDH2
uniprot id: F6RTH7
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

9483:ZDHHC7
gene id: 9483:ZDHHC7
uniprot id: A0A5F4VXT5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:GLDN
gene id: 9483:GLDN
uniprot id: F7I4Y9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TSSK2
gene id: 9483:TSSK2
uniprot id: A0A2R8M342
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:NCEH1
gene id: 9483:NCEH1
uniprot id: U3EYY4
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9483:RPL18
gene id: 9483:RPL18
uniprot id: F6QKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Rough endoplasmic reticulum

9483:RPL17
gene id: 9483:RPL17
uniprot id: F6Q3N9
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9483:PLSCR5
gene id: 9483:PLSCR5
uniprot id: F7IQL8
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9483:FRK
gene id: 9483:FRK
uniprot id: F7HTW0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:PDE6H
gene id: 9483:PDE6H
uniprot id: A0A2R8N3S8
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9483:BORCS5
gene id: 9483:BORCS5
uniprot id: U3DRV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9483:MTHFR
gene id: 9483:MTHFR
uniprot id: U3CLG5
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

9483:LMOD3
gene id: 9483:LMOD3
uniprot id: F7GMF9
names: Subcellular Location Annotation
messages: cytoskeleton

9483:EIF2S1
gene id: 9483:EIF2S1
uniprot id: F7ANJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9483:GLI1
gene id: 9483:GLI1
uniprot id: F7AEX2
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9483:PTER
gene id: 9483:PTER
uniprot id: F7C4K6
uniprot id: F7CJ79
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ATP6V1G2
gene id: 9483:ATP6V1G2
uniprot id: F7IEI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9483:YTHDF2
gene id: 9483:YTHDF2
uniprot id: F6SGT3
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9483:CCNT2
gene id: 9483:CCNT2
uniprot id: F6PJF3
uniprot id: F6TT41
names: Similarity
messages: Belongs to the cyclin family.

9483:PRKAR2A
gene id: 9483:PRKAR2A
uniprot id: F7IC18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9483:CDKN1A
gene id: 9483:CDKN1A
uniprot id: U3E394
names: Similarity
messages: Belongs to the CDI family.

9483:PAX9
gene id: 9483:PAX9
uniprot id: A0A8P2DCF2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

9483:RPA3
gene id: 9483:RPA3
uniprot id: F6ZI81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9483:TOMM40
gene id: 9483:TOMM40
uniprot id: U3BA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:CAP2
gene id: 9483:CAP2
uniprot id: F6ULQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9483:TOR2A
gene id: 9483:TOR2A
uniprot id: A0A2R8MYK2
uniprot id: U3BYS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9483:CHRM5
gene id: 9483:CHRM5
uniprot id: F7FDZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9483:PIR
gene id: 9483:PIR
uniprot id: A0A8I4A1C7
uniprot id: F6TNI5
names: Similarity
messages: Belongs to the pirin family.

9483:LUC7L
gene id: 9483:LUC7L
uniprot id: B0VX80
names: Similarity
messages: Belongs to the Luc7 family.

9483:STARD5
gene id: 9483:STARD5
uniprot id: U3BTT1
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9483:PRKAR2B
gene id: 9483:PRKAR2B
uniprot id: F7ADV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9483:SMARCD3
gene id: 9483:SMARCD3
uniprot id: U3CD19
uniprot id: U3EBF1
names: Similarity
messages: Belongs to the SMARCD family.

9483:CENPK
gene id: 9483:CENPK
uniprot id: A0A8I3W2N6
uniprot id: A0A8J8XEV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9483:PGK1
gene id: 9483:PGK1
uniprot id: F7GSF5
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9483:RBPJ
gene id: 9483:RBPJ
uniprot id: A0A2R8MI49
uniprot id: U3CH38
uniprot id: U3E6R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9483:NTS
gene id: 9483:NTS
uniprot id: F6T798
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9483:PMPCB
gene id: 9483:PMPCB
uniprot id: F7FDX7
names: Similarity
messages: Belongs to the peptidase M16 family.

9483:ELOVL6
gene id: 9483:ELOVL6
uniprot id: A0A2R8MBN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:MYH8
gene id: 9483:MYH8
uniprot id: F7HJA3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:KDELR2
gene id: 9483:KDELR2
uniprot id: A0A5F4W9W6
uniprot id: F7BPN6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CLTRN
gene id: 9483:CLTRN
uniprot id: F7C8H8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:RPL23A
gene id: 9483:RPL23A
uniprot id: F7EJ37
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9483:NDUFC2
gene id: 9483:NDUFC2
uniprot id: F7FET4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9483:FRZB
gene id: 9483:FRZB
uniprot id: A0A5F4WMX9
names: Caution
names: Function
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9483:LOC108587827
gene id: 9483:LOC108587827
uniprot id: A0A8I3W8R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9483:PATL1
gene id: 9483:PATL1
uniprot id: F7IC02
names: Similarity
messages: Belongs to the PAT1 family.

9483:LSM4
gene id: 9483:LSM4
uniprot id: F7HQY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9483:VPS37D
gene id: 9483:VPS37D
uniprot id: F6XCL3
uniprot id: U3DXY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9483:LOC100402586
gene id: 9483:LOC100402586
uniprot id: A0A5F4WJB8
names: Similarity
messages: Belongs to the intermediate filament family.

9483:DDC
gene id: 9483:DDC
uniprot id: A0A2R8MA76
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9483:PPP1R10
gene id: 9483:PPP1R10
uniprot id: F7C1C2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9483:LOC100406067
gene id: 9483:LOC100406067
uniprot id: F7FGM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:CREB5
gene id: 9483:CREB5
uniprot id: F7HFJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

9483:RBCK1
gene id: 9483:RBCK1
uniprot id: U3DDR1
names: Similarity
messages: Belongs to the RBR family.

9483:OCLN
gene id: 9483:OCLN
uniprot id: U3EJL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

9483:TSC22D3
gene id: 9483:TSC22D3
uniprot id: F6R6E0
uniprot id: F7H3M4
uniprot id: F7I9B7
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9483:OLFML3
gene id: 9483:OLFML3
uniprot id: F7I8J0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:YAE1
gene id: 9483:YAE1
uniprot id: F7IGN5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:EPHA6
gene id: 9483:EPHA6
uniprot id: F7GTW3
names: Subcellular Location Annotation
messages: Membrane

9483:NOVA2
gene id: 9483:NOVA2
uniprot id: U3DQR7
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus

9483:AURKAIP1
gene id: 9483:AURKAIP1
uniprot id: F7GKP5
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.

9483:EMSY
gene id: 9483:EMSY
uniprot id: F6QX26
uniprot id: F7APR2
uniprot id: F7AQS1
uniprot id: F7H8N3
names: Subcellular Location Annotation
messages: Nucleus

9483:TMEM234
gene id: 9483:TMEM234
uniprot id: U3EK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

9483:TCP11L1
gene id: 9483:TCP11L1
uniprot id: F6ZT02
names: Similarity
messages: Belongs to the TCP11 family.

9483:EIF1AX
gene id: 9483:EIF1AX
uniprot id: U3BE20
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.

9483:CAV1
gene id: 9483:CAV1
uniprot id: Q2QLG6
uniprot id: U3DG28
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: Membrane raft
messages: Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response.
messages: caveola

9483:IFT43
gene id: 9483:IFT43
uniprot id: F7IQR4
names: Similarity
messages: Belongs to the IFT43 family.

9483:PPP1R3B
gene id: 9483:PPP1R3B
uniprot id: F7FFM0
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9483:MFNG
gene id: 9483:MFNG
uniprot id: U3ECV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:TMEM106B
gene id: 9483:TMEM106B
uniprot id: U3EI86
names: Similarity
messages: Belongs to the TMEM106 family.

9483:WFIKKN2
gene id: 9483:WFIKKN2
uniprot id: A0A5F4VT19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WFIKKN family.
messages: Secreted

9483:SLC28A2
gene id: 9483:SLC28A2
uniprot id: A0A8I3ZZF4
uniprot id: F7GNR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9483:BMP6
gene id: 9483:BMP6
uniprot id: F7FSA8
names: Similarity
messages: Belongs to the TGF-beta family.

9483:ACTN2
gene id: 9483:ACTN2
uniprot id: U3EFF9
names: Similarity
messages: Belongs to the alpha-actinin family.

9483:CD2
gene id: 9483:CD2
uniprot id: A5HJL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:ENPEP
gene id: 9483:ENPEP
uniprot id: F7EVP4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9483:CD164
gene id: 9483:CD164
uniprot id: F7HWM0
uniprot id: U3BR40
uniprot id: U3F455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9483:AK3
gene id: 9483:AK3
uniprot id: U3BDI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9483:PHACTR2
gene id: 9483:PHACTR2
uniprot id: A0A2R8MAG7
uniprot id: A0A2R8PK56
uniprot id: F7HI08
uniprot id: U3DFP6
uniprot id: U3DHU4
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9483:MINAR2
gene id: 9483:MINAR2
uniprot id: F7GS61
names: Similarity
messages: Belongs to the MINAR family.

9483:MAPK4
gene id: 9483:MAPK4
uniprot id: U3ETP2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9483:TM4SF19
gene id: 9483:TM4SF19
uniprot id: F6UJ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9483:ADPRM
gene id: 9483:ADPRM
uniprot id: A0A8I3WDL9
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9483:FHIP1B
gene id: 9483:FHIP1B
uniprot id: U3C4A7
uniprot id: U3CPP9
names: Similarity
messages: Belongs to the FHIP family.

9483:AKAP8
gene id: 9483:AKAP8
uniprot id: F7DAJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKAP95 family.
messages: Nucleus matrix

9483:ARHGDIB
gene id: 9483:ARHGDIB
uniprot id: F7INT7
names: Similarity
messages: Belongs to the Rho GDI family.

9483:PALS1
gene id: 9483:PALS1
uniprot id: A0A8J8XEW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: adherens junction
messages: tight junction

9483:ZNF202
gene id: 9483:ZNF202
uniprot id: F7I290
names: Subcellular Location Annotation
messages: Nucleus

9483:RELL1
gene id: 9483:RELL1
uniprot id: F7FUT1
names: Similarity
messages: Belongs to the RELT family.

9483:VAMP1
gene id: 9483:VAMP1
uniprot id: F6YI66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9483:ATP6V0C
gene id: 9483:ATP6V0C
uniprot id: F7GH31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9483:SGSM1
gene id: 9483:SGSM1
uniprot id: F7HLL0
uniprot id: U3DVM6
names: Similarity
messages: Belongs to the RUTBC family.

9483:IFNG
gene id: 9483:IFNG
uniprot id: B9VS86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9483:LANCL1
gene id: 9483:LANCL1
uniprot id: F7EEA2
names: Similarity
messages: Belongs to the LanC-like protein family.

9483:ACP1
gene id: 9483:ACP1
uniprot id: U3CJJ6
uniprot id: U3F3I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9483:JUNB
gene id: 9483:JUNB
uniprot id: A0A8I4A422
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9483:DNAJC25
gene id: 9483:DNAJC25
uniprot id: F7ESD8
names: Similarity
messages: Belongs to the DNAJC25 family.

9483:FSHR
gene id: 9483:FSHR
uniprot id: C7C615
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

9483:HYAL3
gene id: 9483:HYAL3
uniprot id: A0A2R8M733
uniprot id: F7I8M5
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9483:HOXA7
gene id: 9483:HOXA7
uniprot id: B0VXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9483:ATP2A2
gene id: 9483:ATP2A2
uniprot id: A0A5F4WMB1
uniprot id: A0A8I3VZY4
uniprot id: U3FYJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9483:RIMKLA
gene id: 9483:RIMKLA
uniprot id: F7I0K3
names: Similarity
messages: Belongs to the RimK family.

9483:STAM2
gene id: 9483:STAM2
uniprot id: U3ET33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9483:TPP2
gene id: 9483:TPP2
uniprot id: A0A2R8MEJ0
uniprot id: F7BYW8
names: Similarity
messages: Belongs to the peptidase S8 family.

9483:TBCCD1
gene id: 9483:TBCCD1
uniprot id: U3BAK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9483:MFAP2
gene id: 9483:MFAP2
uniprot id: F7I4B1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:PHYHIPL
gene id: 9483:PHYHIPL
uniprot id: A0A2R8MLX1
names: Similarity
messages: Belongs to the PHYHIP family.

9483:HSP90B1
gene id: 9483:HSP90B1
uniprot id: U3CJF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9483:B3GAT3
gene id: 9483:B3GAT3
uniprot id: F7IBB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:ASB1
gene id: 9483:ASB1
uniprot id: A0A2R8MZZ2
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:SLC16A13
gene id: 9483:SLC16A13
uniprot id: F7HT83
names: Subcellular Location Annotation
messages: Membrane

9483:DAO
gene id: 9483:DAO
uniprot id: F7B5E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9483:SEPSECS
gene id: 9483:SEPSECS
uniprot id: F7GM93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9483:RBBP7
gene id: 9483:RBBP7
uniprot id: A0A2R8N0V5
names: Subcellular Location Annotation
messages: Nucleus

9483:AGL
gene id: 9483:AGL
uniprot id: A0A8I3WN62
uniprot id: U3DB08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

9483:OSBPL9
gene id: 9483:OSBPL9
uniprot id: U3DSA3
names: Similarity
messages: Belongs to the OSBP family.

9483:USP10
gene id: 9483:USP10
uniprot id: F6PHS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:RTBDN
gene id: 9483:RTBDN
uniprot id: U3EWX7
names: Similarity
messages: Belongs to the folate receptor family.

9483:BANF1
gene id: 9483:BANF1
uniprot id: U3DBV0
names: Subcellular Location Annotation
messages: Nucleus

9483:LTB4R
gene id: 9483:LTB4R
uniprot id: A0A5F4W1Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9483:SNRPD2
gene id: 9483:SNRPD2
uniprot id: U3E603
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: cytosol

9483:VCL
gene id: 9483:VCL
uniprot id: A0A5K1UWX2
uniprot id: U3B7Z2
uniprot id: U3FGU8
uniprot id: U3FL37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: podosome

9483:RMND1
gene id: 9483:RMND1
uniprot id: A0A8I3WST0
uniprot id: F7FN68
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9483:TCAF1
gene id: 9483:TCAF1
uniprot id: F7FXG5
names: Similarity
messages: Belongs to the TCAF family.

9483:PSMC3IP
gene id: 9483:PSMC3IP
uniprot id: F7ISJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9483:GNRH1
gene id: 9483:GNRH1
uniprot id: U3CDM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

9483:LOC100393949
gene id: 9483:LOC100393949
uniprot id: F7IT04
names: Similarity
messages: Belongs to the PRORSD1 family.

9483:SUFU
gene id: 9483:SUFU
uniprot id: F6U4B5
uniprot id: U3FX06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9483:LOC100407762
gene id: 9483:LOC100407762
uniprot id: A0A8I3W090
names: Similarity
messages: Belongs to the LCE family.

9483:LOC103796642
gene id: 9483:LOC103796642
uniprot id: A0A5F4VU17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9483:LOC100403294
gene id: 9483:LOC100403294
uniprot id: F7IFP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:EIF4ENIF1
gene id: 9483:EIF4ENIF1
uniprot id: B0KWR5
names: Subcellular Location Annotation
messages: Cytoplasm

9483:GLRA2
gene id: 9483:GLRA2
uniprot id: U3CG39
uniprot id: U3FXG3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9483:POMT2
gene id: 9483:POMT2
uniprot id: A0A8I3W598
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9483:GAD1
gene id: 9483:GAD1
uniprot id: U3DTP3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9483:NIT1
gene id: 9483:NIT1
uniprot id: U3BSW4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9483:ATF1
gene id: 9483:ATF1
uniprot id: A0A2R8P9U0
names: Subcellular Location Annotation
messages: Nucleus

9483:C4BPA
gene id: 9483:C4BPA
uniprot id: F7IKA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:DPY30
gene id: 9483:DPY30
uniprot id: F7IR99
names: Similarity
messages: Belongs to the dpy-30 family.

9483:MPHOSPH10
gene id: 9483:MPHOSPH10
uniprot id: U3DY58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9483:GLRA1
gene id: 9483:GLRA1
uniprot id: F6ZNX7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

9483:DOCK4
gene id: 9483:DOCK4
uniprot id: U3CZS7
uniprot id: U3F8D9
names: Similarity
messages: Belongs to the DOCK family.

9483:PPFIBP2
gene id: 9483:PPFIBP2
uniprot id: A0A5F4W4S2
uniprot id: U3EQ27
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9483:NUDCD1
gene id: 9483:NUDCD1
uniprot id: U3DVM1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:C2H5orf24
gene id: 9483:C2H5orf24
uniprot id: F7DCU5
uniprot id: F7HZ39
names: Similarity
messages: Belongs to the UPF0461 family.

9483:LOC100389093
gene id: 9483:LOC100389093
uniprot id: B0VXB5
uniprot id: Q9GJS7
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
messages: Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).
messages: Red blood cells.

9483:CDC42
gene id: 9483:CDC42
uniprot id: F7HMJ4
uniprot id: U3DLZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

9483:SLC39A1
gene id: 9483:SLC39A1
uniprot id: U3BBV7
names: Subcellular Location Annotation
messages: Membrane

9483:XPA
gene id: 9483:XPA
uniprot id: U3DQN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9483:MSR1
gene id: 9483:MSR1
uniprot id: F6QM72
names: Subcellular Location Annotation
messages: Membrane

9483:SLC35A3
gene id: 9483:SLC35A3
uniprot id: A0A8I3WA46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:RASGRP1
gene id: 9483:RASGRP1
uniprot id: F7FFF2
names: Similarity
messages: Belongs to the RASGRP family.

9483:HAPSTR1
gene id: 9483:HAPSTR1
uniprot id: F7IJL5
names: Subcellular Location Annotation
messages: Nucleus

9483:ETS1
gene id: 9483:ETS1
uniprot id: F7C4P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9483:ST8SIA3
gene id: 9483:ST8SIA3
uniprot id: F7I126
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:PRKCH
gene id: 9483:PRKCH
uniprot id: F7HD36
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9483:TM9SF2
gene id: 9483:TM9SF2
uniprot id: U3EFD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9483:LOC100407094
gene id: 9483:LOC100407094
uniprot id: A0A5F4WMU4
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9483:GUCY1A1
gene id: 9483:GUCY1A1
uniprot id: F7IRP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9483:LNPEP
gene id: 9483:LNPEP
uniprot id: A0A8I3W2L7
uniprot id: F7HKT3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9483:STX1B
gene id: 9483:STX1B
uniprot id: U3F4G9
names: Similarity
messages: Belongs to the syntaxin family.

9483:SLC35B3
gene id: 9483:SLC35B3
uniprot id: A0A8I3W6G3
uniprot id: A0A8I3W9C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9483:NTSR2
gene id: 9483:NTSR2
uniprot id: F6S1P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TMEM88B
gene id: 9483:TMEM88B
uniprot id: F7GWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9483:CSNK1G3
gene id: 9483:CSNK1G3
uniprot id: A0A8J8XS38
uniprot id: F7DPL9
uniprot id: U3AVV3
uniprot id: U3E6K8
uniprot id: U3F5Z4
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9483:IFIH1
gene id: 9483:IFIH1
uniprot id: F7IN54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9483:LCMT1
gene id: 9483:LCMT1
uniprot id: U3B7Q5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9483:GDI1
gene id: 9483:GDI1
uniprot id: U3CX66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9483:ANKRD34C
gene id: 9483:ANKRD34C
uniprot id: U3FA74
names: Similarity
messages: Belongs to the ANKRD34 family.

9483:STC2
gene id: 9483:STC2
uniprot id: F7E3T2
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9483:SLC30A7
gene id: 9483:SLC30A7
uniprot id: F7DID4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Homooligomer.
messages: Membrane
messages: trans-Golgi network membrane

9483:UBE2I
gene id: 9483:UBE2I
uniprot id: A0A2R8PFF1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:OOSP2
gene id: 9483:OOSP2
uniprot id: A0A2R8MBX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9483:XPNPEP2
gene id: 9483:XPNPEP2
uniprot id: F7CGS9
names: Similarity
messages: Belongs to the peptidase M24B family.

9483:NMD3
gene id: 9483:NMD3
uniprot id: F7BFU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9483:GNPTAB
gene id: 9483:GNPTAB
uniprot id: U3E781
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

9483:E2F4
gene id: 9483:E2F4
uniprot id: F7BSL2
uniprot id: U3DRH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9483:SLC25A21
gene id: 9483:SLC25A21
uniprot id: U3BRH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:TP63
gene id: 9483:TP63
uniprot id: A0A2R8P0K0
uniprot id: F7I720
uniprot id: F7I9D3
uniprot id: U3E412
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Nucleus

9483:CCDC43
gene id: 9483:CCDC43
uniprot id: F7HU86
names: Similarity
messages: Belongs to the CCDC43 family.

9483:HOMEZ
gene id: 9483:HOMEZ
uniprot id: F7IG63
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100398638
gene id: 9483:LOC100398638
uniprot id: F7F3A7
names: Similarity
messages: Belongs to the PRR20 family.

9483:EPHA7
gene id: 9483:EPHA7
uniprot id: F6XPG2
uniprot id: U3DW98
names: Subcellular Location Annotation
messages: Membrane

9483:RPL21
gene id: 9483:RPL21
uniprot id: A0A2R8MC53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9483:NR1H3
gene id: 9483:NR1H3
uniprot id: U3FGX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9483:GPR87
gene id: 9483:GPR87
uniprot id: A0A2R8MD25
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:YWHAB
gene id: 9483:YWHAB
uniprot id: U3F717
names: Similarity
messages: Belongs to the 14-3-3 family.

9483:CAPZB
gene id: 9483:CAPZB
uniprot id: F7H329
uniprot id: F7H3P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton
messages: sarcomere

9483:DUS4L
gene id: 9483:DUS4L
uniprot id: F6RTL3
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9483:C12H10orf53
gene id: 9483:C12H10orf53
uniprot id: F7H8W0
names: Similarity
messages: Belongs to the UPF0728 family.

9483:DEDD2
gene id: 9483:DEDD2
uniprot id: U3D5N1
names: Subcellular Location Annotation
messages: nucleolus

9483:ADORA2A
gene id: 9483:ADORA2A
uniprot id: A0A8I3X4X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9483:CBX5
gene id: 9483:CBX5
uniprot id: F7IG39
names: Subcellular Location Annotation
messages: Nucleus

9483:PML
gene id: 9483:PML
uniprot id: F6SXY7
uniprot id: F6TV43
names: Subcellular Location Annotation
messages: Cytoplasm

9483:NR5A2
gene id: 9483:NR5A2
uniprot id: A0A2R8MHR1
uniprot id: F7I1I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9483:P3H2
gene id: 9483:P3H2
uniprot id: F7HVC6
names: Similarity
messages: Belongs to the leprecan family.

9483:TXN
gene id: 9483:TXN
uniprot id: Q9BDJ3
uniprot id: U3CTN3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioredoxin family.
messages: Cytoplasm
messages: Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (By similarity).
messages: In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity).
messages: Nucleus
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
messages: Secreted

9483:TBL1XR1
gene id: 9483:TBL1XR1
uniprot id: U3FNT4
names: Similarity
messages: Belongs to the WD repeat EBI family.

9483:NPC2
gene id: 9483:NPC2
uniprot id: F7HX33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9483:LOC100400142
gene id: 9483:LOC100400142
uniprot id: F7FN63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9483:RAP1GDS1
gene id: 9483:RAP1GDS1
uniprot id: A0A5K1VHP6
uniprot id: U3FS21
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion

9483:GSK3A
gene id: 9483:GSK3A
uniprot id: F7HP16
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9483:SLC27A5
gene id: 9483:SLC27A5
uniprot id: A0A8I3WP13
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:LMCD1
gene id: 9483:LMCD1
uniprot id: A0A8I3WRW8
uniprot id: U3C7A7
names: Function
names: Subunit
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.

9483:ZNF24
gene id: 9483:ZNF24
uniprot id: F7HFP7
names: Subcellular Location Annotation
messages: Nucleus

9483:PIPOX
gene id: 9483:PIPOX
uniprot id: F7GSN9
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9483:FABP2
gene id: 9483:FABP2
uniprot id: F7HKK2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:ARMT1
gene id: 9483:ARMT1
uniprot id: U3F6H0
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

9483:CLPTM1
gene id: 9483:CLPTM1
uniprot id: U3FUB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9483:ANKZF1
gene id: 9483:ANKZF1
uniprot id: A0A5F4WEP3
uniprot id: F6QSL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

9483:GAP43
gene id: 9483:GAP43
uniprot id: A0A8I4A0D1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9483:PUS7L
gene id: 9483:PUS7L
uniprot id: A0A8I3WK96
uniprot id: F6S2V2
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9483:LSM6
gene id: 9483:LSM6
uniprot id: U3EDF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9483:ERO1A
gene id: 9483:ERO1A
uniprot id: U3EXB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9483:MFSD8
gene id: 9483:MFSD8
uniprot id: F6V932
uniprot id: U3FT36
names: Subcellular Location Annotation
messages: Membrane

9483:PLA2G5
gene id: 9483:PLA2G5
uniprot id: A0A8I3W0F9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9483:OLA1
gene id: 9483:OLA1
uniprot id: U3DTY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

9483:LOC100386748
gene id: 9483:LOC100386748
uniprot id: F7HYF5
names: Similarity
messages: Belongs to the GAGE family.

9483:NKX2-5
gene id: 9483:NKX2-5
uniprot id: A0A8I3X2B3
names: Subcellular Location Annotation
messages: Nucleus

9483:HAUS3
gene id: 9483:HAUS3
uniprot id: U3ESN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9483:ZNF215
gene id: 9483:ZNF215
uniprot id: F6YZN4
names: Subcellular Location Annotation
messages: Nucleus

9483:UBA3
gene id: 9483:UBA3
uniprot id: F6QVE0
uniprot id: F6R524
uniprot id: U3DEY7
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9483:RECQL5
gene id: 9483:RECQL5
uniprot id: U3FTT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9483:CNMD
gene id: 9483:CNMD
uniprot id: F7HB30
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9483:IL17C
gene id: 9483:IL17C
uniprot id: A0A8I3WCW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9483:GJA3
gene id: 9483:GJA3
uniprot id: A0A2R8P4Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:TBRG1
gene id: 9483:TBRG1
uniprot id: U3F8Y8
names: Subcellular Location Annotation
messages: Nucleus

9483:RNF146
gene id: 9483:RNF146
uniprot id: F7HB59
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9483:KCNE3
gene id: 9483:KCNE3
uniprot id: A0A2R8MJA3
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9483:HOXA1
gene id: 9483:HOXA1
uniprot id: B0VXK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9483:CD63
gene id: 9483:CD63
uniprot id: U3CZ61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9483:PLD5
gene id: 9483:PLD5
uniprot id: A0A5F4WFM5
uniprot id: U3CMZ1
names: Similarity
messages: Belongs to the phospholipase D family.

9483:SLC25A24
gene id: 9483:SLC25A24
uniprot id: U3F990
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:ERFL
gene id: 9483:ERFL
uniprot id: F7GS67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:DONSON
gene id: 9483:DONSON
uniprot id: U3DX17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

9483:SLC25A27
gene id: 9483:SLC25A27
uniprot id: A0A8I4A4E2
uniprot id: U3EW66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:LOC100385257
gene id: 9483:LOC100385257
uniprot id: U3D2S2
names: Similarity
messages: Belongs to the peptidase C14A family.

9483:FES
gene id: 9483:FES
uniprot id: F7IBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9483:AKAP8L
gene id: 9483:AKAP8L
uniprot id: U3CVL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKAP95 family.
messages: Nucleus matrix

9483:NKAIN1
gene id: 9483:NKAIN1
uniprot id: U3EGE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9483:ANXA1
gene id: 9483:ANXA1
uniprot id: F7IL52
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9483:TARS1
gene id: 9483:TARS1
uniprot id: U3FHJ0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9483:LHX9
gene id: 9483:LHX9
uniprot id: F7I3D2
names: Subcellular Location Annotation
messages: Nucleus

9483:DYNLL1
gene id: 9483:DYNLL1
uniprot id: F6UCC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9483:OCEL1
gene id: 9483:OCEL1
uniprot id: F7IEP3
names: Similarity
messages: Belongs to the ELL/occludin family.

9483:NEUROD1
gene id: 9483:NEUROD1
uniprot id: F6SAJ7
names: Subcellular Location Annotation
messages: Nucleus

9483:TP53
gene id: 9483:TP53
uniprot id: F7GNX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9483:OXSM
gene id: 9483:OXSM
uniprot id: U3EWR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9483:LOC100414020
gene id: 9483:LOC100414020
uniprot id: A0A5F4W5M3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

9483:ELP3
gene id: 9483:ELP3
uniprot id: F6Z4B9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9483:RPL35A
gene id: 9483:RPL35A
uniprot id: A0A8I3W0W2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9483:RIN2
gene id: 9483:RIN2
uniprot id: A0A8I3WPG1
uniprot id: A0A8I4A235
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9483:PELO
gene id: 9483:PELO
uniprot id: U3C932
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
messages: Cytoplasm

9483:LOC100400493
gene id: 9483:LOC100400493
uniprot id: F7IFF1
names: Subcellular Location Annotation
messages: Nucleus

9483:CHRDL2
gene id: 9483:CHRDL2
uniprot id: A0A8I4A384
names: Subcellular Location Annotation
messages: Secreted

9483:FAS
gene id: 9483:FAS
uniprot id: A8WEX9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

9483:TMEM150A
gene id: 9483:TMEM150A
uniprot id: F7FKV8
names: Subcellular Location Annotation
messages: Membrane

9483:BTD
gene id: 9483:BTD
uniprot id: F7ED31
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9483:DPAGT1
gene id: 9483:DPAGT1
uniprot id: F6VZ52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:STAM
gene id: 9483:STAM
uniprot id: F7E7C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9483:NBL1
gene id: 9483:NBL1
uniprot id: A0A8I3W5B0
uniprot id: F7HWY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9483:NEUROD6
gene id: 9483:NEUROD6
uniprot id: F6W8P8
names: Subcellular Location Annotation
messages: Nucleus

9483:CRH
gene id: 9483:CRH
uniprot id: F7I0T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9483:TIMP1
gene id: 9483:TIMP1
uniprot id: U3CUE7
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9483:NAP1L1
gene id: 9483:NAP1L1
uniprot id: A0A5F4WE21
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:CLSTN2
gene id: 9483:CLSTN2
uniprot id: F7GNK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

9483:LCLAT1
gene id: 9483:LCLAT1
uniprot id: A0A2R8MKZ9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9483:OGT
gene id: 9483:OGT
uniprot id: F7G0L9
uniprot id: U3EFN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9483:CROT
gene id: 9483:CROT
uniprot id: F7ENF8
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9483:DCP2
gene id: 9483:DCP2
uniprot id: A0A8J8Y249
uniprot id: U3C2I7
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9483:ADAMTS6
gene id: 9483:ADAMTS6
uniprot id: F7B3K4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:PLOD2
gene id: 9483:PLOD2
uniprot id: U3CUC8
uniprot id: U3E4Z2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9483:SMARCD1
gene id: 9483:SMARCD1
uniprot id: F7FTP4
uniprot id: F7G3A0
names: Similarity
messages: Belongs to the SMARCD family.

9483:UPK1B
gene id: 9483:UPK1B
uniprot id: F7BN59
names: Subcellular Location Annotation
messages: Membrane

9483:SPON1
gene id: 9483:SPON1
uniprot id: F7G1Q5
names: Subcellular Location Annotation
messages: extracellular matrix

9483:SELE
gene id: 9483:SELE
uniprot id: F7F2X2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:STXBP1
gene id: 9483:STXBP1
uniprot id: F6SYW8
uniprot id: F7IMD1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9483:BMP8A
gene id: 9483:BMP8A
uniprot id: F7IM63
names: Similarity
messages: Belongs to the TGF-beta family.

9483:SMC1B
gene id: 9483:SMC1B
uniprot id: F6RQV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9483:UCP1
gene id: 9483:UCP1
uniprot id: F7HVY5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

9483:TGM3
gene id: 9483:TGM3
uniprot id: F7IIF1
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9483:BCOR
gene id: 9483:BCOR
uniprot id: A0A8J8XZ08
names: Similarity
messages: Belongs to the BCOR family.

9483:TMEM135
gene id: 9483:TMEM135
uniprot id: U3EST0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane

9483:CLGN
gene id: 9483:CLGN
uniprot id: A0A5F4VT31
names: Similarity
messages: Belongs to the calreticulin family.

9483:PRCP
gene id: 9483:PRCP
uniprot id: A0A8I3X9G7
names: Similarity
messages: Belongs to the peptidase S28 family.

9483:SCGB2A1
gene id: 9483:SCGB2A1
uniprot id: F7HX07
names: Subcellular Location Annotation
messages: Secreted

9483:ANXA8L1
gene id: 9483:ANXA8L1
uniprot id: A0A2R8NCV0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9483:AHR
gene id: 9483:AHR
uniprot id: F6X3Y4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:PLRG1
gene id: 9483:PLRG1
uniprot id: U3DWJ5
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9483:TSPAN5
gene id: 9483:TSPAN5
uniprot id: F6X7Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:F2R
gene id: 9483:F2R
uniprot id: U3F0Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:JOSD2
gene id: 9483:JOSD2
uniprot id: U3DD69
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOX
gene id: 9483:LOX
uniprot id: A0A2R8MXE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9483:TAF10
gene id: 9483:TAF10
uniprot id: F7AXR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

9483:RBL2
gene id: 9483:RBL2
uniprot id: U3FTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9483:C6H2orf76
gene id: 9483:C6H2orf76
uniprot id: F7EYC0
names: Similarity
messages: Belongs to the UPF0538 family.

9483:GAMT
gene id: 9483:GAMT
uniprot id: U3D5X2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.
messages: Monomer.

9483:SNX1
gene id: 9483:SNX1
uniprot id: F7I414
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9483:VXN
gene id: 9483:VXN
uniprot id: U3E0B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vexin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus

9483:ADGRB3
gene id: 9483:ADGRB3
uniprot id: U3DYQ3
names: Subcellular Location Annotation
messages: Membrane

9483:PLPPR2
gene id: 9483:PLPPR2
uniprot id: U3EB96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9483:PRKAR1A
gene id: 9483:PRKAR1A
uniprot id: U3F3H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9483:DCTPP1
gene id: 9483:DCTPP1
uniprot id: U3E7J8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9483:TBX21
gene id: 9483:TBX21
uniprot id: A0A2R8MZJ4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:ATL1
gene id: 9483:ATL1
uniprot id: U3EKI1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9483:PARP1
gene id: 9483:PARP1
uniprot id: U3DZQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

9483:OLFR651
gene id: 9483:OLFR651
uniprot id: B0VXD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SF3A3
gene id: 9483:SF3A3
uniprot id: F6YRE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

9483:LOC100388165
gene id: 9483:LOC100388165
uniprot id: F7I4U5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:SNX30
gene id: 9483:SNX30
uniprot id: U3F1I2
names: Similarity
messages: Belongs to the sorting nexin family.

9483:TMEM54
gene id: 9483:TMEM54
uniprot id: F7BVY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9483:FAM151A
gene id: 9483:FAM151A
uniprot id: F6UFE2
names: Similarity
messages: Belongs to the FAM151 family.

9483:NOX1
gene id: 9483:NOX1
uniprot id: U3BPB7
names: Subcellular Location Annotation
messages: Membrane

9483:MCMBP
gene id: 9483:MCMBP
uniprot id: U3E9M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

9483:TFAP2A
gene id: 9483:TFAP2A
uniprot id: A0A8I3W3Z2
uniprot id: F7G4A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9483:RPL36A
gene id: 9483:RPL36A
uniprot id: F7IHF9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9483:PIERCE1
gene id: 9483:PIERCE1
uniprot id: U3FKY6
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9483:SFMBT1
gene id: 9483:SFMBT1
uniprot id: F7BZT4
names: Subcellular Location Annotation
messages: Nucleus

9483:STX6
gene id: 9483:STX6
uniprot id: F6ZQT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

9483:LOC100385521
gene id: 9483:LOC100385521
uniprot id: A0A5F4WK63
names: Similarity
messages: Belongs to the gonadal family.

9483:PPFIA2
gene id: 9483:PPFIA2
uniprot id: U3CJ29
uniprot id: U3EZ11
uniprot id: U3F7N7
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9483:DICER1
gene id: 9483:DICER1
uniprot id: F6W4T4
names: Function
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

9483:NUDT3
gene id: 9483:NUDT3
uniprot id: F6UJG1
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9483:GRPEL2
gene id: 9483:GRPEL2
uniprot id: U3BNI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9483:LOC100385103
gene id: 9483:LOC100385103
uniprot id: F6R8W5
uniprot id: F7GYJ8
uniprot id: U3B2I5
names: Similarity
messages: Belongs to the GroES chaperonin family.
messages: Belongs to the MOB1/phocein family.

9483:JAKMIP2
gene id: 9483:JAKMIP2
uniprot id: U3CMM4
names: Similarity
messages: Belongs to the JAKMIP family.

9483:RIMKLB
gene id: 9483:RIMKLB
uniprot id: F6ZQC0
names: Similarity
messages: Belongs to the RimK family.

9483:MTHFS
gene id: 9483:MTHFS
uniprot id: U3CWB8
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

9483:MTMR4
gene id: 9483:MTMR4
uniprot id: U3DNI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9483:VTI1A
gene id: 9483:VTI1A
uniprot id: A0A2R8MZ66
uniprot id: F7IIA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9483:PPP2R3C
gene id: 9483:PPP2R3C
uniprot id: F7EHK2
names: Subcellular Location Annotation
messages: Nucleus

9483:RCE1
gene id: 9483:RCE1
uniprot id: U3EM47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:CREG1
gene id: 9483:CREG1
uniprot id: U3FJ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9483:PKIA
gene id: 9483:PKIA
uniprot id: A0A8I3WG41
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9483:LMLN
gene id: 9483:LMLN
uniprot id: A0A8J8XWA4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

9483:LOC100401782
gene id: 9483:LOC100401782
uniprot id: F7DMR1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:EEF1G
gene id: 9483:EEF1G
uniprot id: U3FNE8
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9483:RET
gene id: 9483:RET
uniprot id: F7I536
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

9483:MRPL33
gene id: 9483:MRPL33
uniprot id: U3CMP0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9483:ETV3
gene id: 9483:ETV3
uniprot id: F7EJE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:NDUFA2
gene id: 9483:NDUFA2
uniprot id: A0A2R8N2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:RNF114
gene id: 9483:RNF114
uniprot id: F6U6P9
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
messages: Nucleus

9483:RALY
gene id: 9483:RALY
uniprot id: F6ZUD9
uniprot id: U3EXQ5
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9483:PBX3
gene id: 9483:PBX3
uniprot id: F6YSM0
uniprot id: F6ZJS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9483:SLC9A9
gene id: 9483:SLC9A9
uniprot id: U3BWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9483:F2RL3
gene id: 9483:F2RL3
uniprot id: F7IPB8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:SMYD2
gene id: 9483:SMYD2
uniprot id: U3FFG0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
messages: cytosol

9483:CALCA
gene id: 9483:CALCA
uniprot id: U3EPP1
names: Similarity
messages: Belongs to the calcitonin family.

9483:LOC100407286
gene id: 9483:LOC100407286
uniprot id: U3E4E5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:BUD31
gene id: 9483:BUD31
uniprot id: F7I7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9483:OR10G3
gene id: 9483:OR10G3
uniprot id: F7G5T7
names: Subcellular Location Annotation
messages: Membrane

9483:SHBG
gene id: 9483:SHBG
uniprot id: F7E805
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:BRINP1
gene id: 9483:BRINP1
uniprot id: F6YUW3
names: Similarity
messages: Belongs to the BRINP family.

9483:CAT
gene id: 9483:CAT
uniprot id: Q2I6W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
messages: Homotetramer. Interacts (via microbody targeting signal) with PEX5, monomeric form interacts with PEX5, leading to its translocation into peroxisomes.
messages: Peroxisome

9483:EIF1
gene id: 9483:EIF1
uniprot id: A0A2R8M2V6
names: Similarity
messages: Belongs to the SUI1 family.

9483:SST
gene id: 9483:SST
uniprot id: F7IIT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9483:POU4F2
gene id: 9483:POU4F2
uniprot id: F6W7V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9483:ADAMTS1
gene id: 9483:ADAMTS1
uniprot id: F6X3H6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:CDK4
gene id: 9483:CDK4
uniprot id: F7DPY6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:PTN
gene id: 9483:PTN
uniprot id: U3F5N5
names: Similarity
messages: Belongs to the pleiotrophin family.

9483:PNPLA7
gene id: 9483:PNPLA7
uniprot id: U3FPM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:AMFR
gene id: 9483:AMFR
uniprot id: U3DJU5
names: Subcellular Location Annotation
messages: Membrane

9483:MRAP2
gene id: 9483:MRAP2
uniprot id: F7HEG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:LOC100385449
gene id: 9483:LOC100385449
uniprot id: H9KXI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9483:HTR7
gene id: 9483:HTR7
uniprot id: U3E1W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:FZD2
gene id: 9483:FZD2
uniprot id: A0A2R8MXI9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:TSR1
gene id: 9483:TSR1
uniprot id: U3EBS8
names: Subcellular Location Annotation
messages: nucleolus

9483:KCNH5
gene id: 9483:KCNH5
uniprot id: A0A8I3WZX1
names: Subcellular Location Annotation
messages: Membrane

9483:TAS2R8
gene id: 9483:TAS2R8
uniprot id: A0A8I3WVY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9483:HTR1D
gene id: 9483:HTR1D
uniprot id: F6V9Y1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9483:DLX1
gene id: 9483:DLX1
uniprot id: A0A2R8N712
names: Subcellular Location Annotation
messages: Nucleus

9483:RETN
gene id: 9483:RETN
uniprot id: A0A8I3W9M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9483:KCNK10
gene id: 9483:KCNK10
uniprot id: F7IJI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9483:LOC108593825
gene id: 9483:LOC108593825
uniprot id: A0A8I3WKX0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:LDLRAD3
gene id: 9483:LDLRAD3
uniprot id: U3C0H8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TK1
gene id: 9483:TK1
uniprot id: U3DTW2
names: Similarity
messages: Belongs to the thymidine kinase family.

9483:SLC4A4
gene id: 9483:SLC4A4
uniprot id: U3CFQ7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9483:DDR2
gene id: 9483:DDR2
uniprot id: U3DLY1
names: Subcellular Location Annotation
messages: Membrane

9483:MRE11
gene id: 9483:MRE11
uniprot id: U3CS03
uniprot id: U3E822
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9483:SH3GLB1
gene id: 9483:SH3GLB1
uniprot id: F7AEZ1
uniprot id: F7BKI7
uniprot id: U3CI10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9483:FAM110A
gene id: 9483:FAM110A
uniprot id: F7I204
names: Similarity
messages: Belongs to the FAM110 family.

9483:LOC100385852
gene id: 9483:LOC100385852
uniprot id: B0VXD3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:E2F2
gene id: 9483:E2F2
uniprot id: F7IIE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9483:GAS8
gene id: 9483:GAS8
uniprot id: F6RWJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum
messages: flagellum axoneme

9483:ITGB3
gene id: 9483:ITGB3
uniprot id: U3B9A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9483:MRPL24
gene id: 9483:MRPL24
uniprot id: F7IIC7
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:CRIPT
gene id: 9483:CRIPT
uniprot id: F6UYR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

9483:S1PR5
gene id: 9483:S1PR5
uniprot id: F6QIC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CPO
gene id: 9483:CPO
uniprot id: F7IIG5
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:SDAD1
gene id: 9483:SDAD1
uniprot id: U3D3A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9483:HMGB3
gene id: 9483:HMGB3
uniprot id: F6RM23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9483:SLC27A4
gene id: 9483:SLC27A4
uniprot id: U3C442
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:SH3YL1
gene id: 9483:SH3YL1
uniprot id: U3AVX4
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9483:UCKL1
gene id: 9483:UCKL1
uniprot id: F6TEI4
uniprot id: F6VUW7
uniprot id: U3DT03
names: Similarity
messages: Belongs to the uridine kinase family.

9483:MRPL22
gene id: 9483:MRPL22
uniprot id: U3BBJ6
uniprot id: U3CDI0
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9483:GOSR2
gene id: 9483:GOSR2
uniprot id: U3DCE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9483:CYLD
gene id: 9483:CYLD
uniprot id: U3BXL9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9483:LOC100412398
gene id: 9483:LOC100412398
uniprot id: B0VXC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:RARS1
gene id: 9483:RARS1
uniprot id: A0A8I3WXP7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9483:GLCE
gene id: 9483:GLCE
uniprot id: A0A2R8MWH6
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9483:MAP2K6
gene id: 9483:MAP2K6
uniprot id: U3FRL0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:ARPC5L
gene id: 9483:ARPC5L
uniprot id: U3DAD1
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9483:B3GNT5
gene id: 9483:B3GNT5
uniprot id: F7IAI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:TMA7
gene id: 9483:TMA7
uniprot id: A0A8I3WZZ0
names: Similarity
messages: Belongs to the TMA7 family.

9483:ACKR3
gene id: 9483:ACKR3
uniprot id: F7HZX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:DDX50
gene id: 9483:DDX50
uniprot id: F7I8W5
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9483:LOC100410178
gene id: 9483:LOC100410178
uniprot id: A0A2R8MSK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC100398454
gene id: 9483:LOC100398454
uniprot id: F7I4P0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9483:NPAS4
gene id: 9483:NPAS4
uniprot id: F6WSP4
names: Subcellular Location Annotation
messages: Nucleus

9483:HSPA14
gene id: 9483:HSPA14
uniprot id: U3BDK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9483:ARID5B
gene id: 9483:ARID5B
uniprot id: A0A5F4VT45
uniprot id: U3DDH1
names: Similarity
messages: Belongs to the ARID5B family.

9483:MTRFR
gene id: 9483:MTRFR
uniprot id: F6Y5X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9483:PSMA1
gene id: 9483:PSMA1
uniprot id: F7GW13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:TUBB1
gene id: 9483:TUBB1
uniprot id: A0A8I3W422
uniprot id: F7I1T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9483:MTMR1
gene id: 9483:MTMR1
uniprot id: A0A5F4VTC2
uniprot id: A0A8I4A3H4
uniprot id: F6S6Y4
uniprot id: F7I3L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9483:WDR12
gene id: 9483:WDR12
uniprot id: U3B9L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9483:IRAK2
gene id: 9483:IRAK2
uniprot id: U3F779
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9483:NDST1
gene id: 9483:NDST1
uniprot id: F7HGK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9483:NIPSNAP3A
gene id: 9483:NIPSNAP3A
uniprot id: F7C559
names: Similarity
messages: Belongs to the NipSnap family.

9483:OPTN
gene id: 9483:OPTN
uniprot id: A0A5K1UNZ7
uniprot id: F7I7M0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Recycling endosome
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9483:HMGCR
gene id: 9483:HMGCR
uniprot id: F7IAE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

9483:SERF2
gene id: 9483:SERF2
uniprot id: A0A5F4VW37
names: Similarity
messages: Belongs to the SERF family.

9483:LOC100399827
gene id: 9483:LOC100399827
uniprot id: F7DH04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SMPD3
gene id: 9483:SMPD3
uniprot id: F6ZLI1
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9483:LOC100391380
gene id: 9483:LOC100391380
uniprot id: F7HAR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:MYORG
gene id: 9483:MYORG
uniprot id: U3CW44
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9483:BZW2
gene id: 9483:BZW2
uniprot id: U3DY16
names: Similarity
messages: Belongs to the BZW family.

9483:LOC100400561
gene id: 9483:LOC100400561
uniprot id: F7I4G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PLK3
gene id: 9483:PLK3
uniprot id: U3D713
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9483:CXCL10
gene id: 9483:CXCL10
uniprot id: A0A2R8MWC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:OR4D5
gene id: 9483:OR4D5
uniprot id: F7IT60
names: Subcellular Location Annotation
messages: Membrane

9483:NAA60
gene id: 9483:NAA60
uniprot id: F7D7P8
names: Subcellular Location Annotation
messages: Nucleus

9483:CDC37
gene id: 9483:CDC37
uniprot id: F7GXW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9483:TINAGL1
gene id: 9483:TINAGL1
uniprot id: F7HD12
names: Similarity
messages: Belongs to the peptidase C1 family.

9483:TBX10
gene id: 9483:TBX10
uniprot id: U3EAC5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:GBE1
gene id: 9483:GBE1
uniprot id: F7GS69
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

9483:ADISSP
gene id: 9483:ADISSP
uniprot id: F7FSS4
names: Similarity
messages: Belongs to the ADISSP family.

9483:AK4
gene id: 9483:AK4
uniprot id: F7GT48
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9483:MYOZ1
gene id: 9483:MYOZ1
uniprot id: F7I6S9
names: Similarity
messages: Belongs to the myozenin family.

9483:STK11IP
gene id: 9483:STK11IP
uniprot id: B0KWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

9483:PGM2
gene id: 9483:PGM2
uniprot id: U3FIK5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9483:AMIGO1
gene id: 9483:AMIGO1
uniprot id: F7ILS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9483:GCG
gene id: 9483:GCG
uniprot id: F7ID40
names: Similarity
messages: Belongs to the glucagon family.

9483:SEPTIN11
gene id: 9483:SEPTIN11
uniprot id: U3EPD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9483:LOC100414177
gene id: 9483:LOC100414177
uniprot id: F6R067
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:STK17A
gene id: 9483:STK17A
uniprot id: U3B905
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:ABI1
gene id: 9483:ABI1
uniprot id: F7I891
uniprot id: U3CMW2
uniprot id: U3CY87
uniprot id: U3EDP8
uniprot id: U3ELE5
uniprot id: U3EP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9483:PPP1R2
gene id: 9483:PPP1R2
uniprot id: F6ZFQ3
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9483:ZNF394
gene id: 9483:ZNF394
uniprot id: U3BRZ8
names: Subcellular Location Annotation
messages: Nucleus

9483:MPP7
gene id: 9483:MPP7
uniprot id: F7GFG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9483:COG2
gene id: 9483:COG2
uniprot id: U3FQL4
names: Similarity
messages: Belongs to the COG2 family.

9483:LOC100386936
gene id: 9483:LOC100386936
uniprot id: F6TU06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9483:TSSK6
gene id: 9483:TSSK6
uniprot id: H9KXW8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:GLRX
gene id: 9483:GLRX
uniprot id: F7HFZ7
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9483:RGMB
gene id: 9483:RGMB
uniprot id: U3DJI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9483:KDM5B
gene id: 9483:KDM5B
uniprot id: F7HNX8
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

9483:ADD1
gene id: 9483:ADD1
uniprot id: A0A8J8XYQ9
uniprot id: U3E195
uniprot id: U3F0E8
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9483:SLC16A9
gene id: 9483:SLC16A9
uniprot id: F6SCZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane

9483:TBR1
gene id: 9483:TBR1
uniprot id: A0A8I3W3Z3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:LOC100397654
gene id: 9483:LOC100397654
uniprot id: U3DMU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9483:CYP3A90
gene id: 9483:CYP3A90
uniprot id: B1NL96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9483:RPL37
gene id: 9483:RPL37
uniprot id: F6YVB8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9483:LOC100390127
gene id: 9483:LOC100390127
uniprot id: F7DXQ1
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9483:NCSTN
gene id: 9483:NCSTN
uniprot id: U3CT98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9483:PCYOX1L
gene id: 9483:PCYOX1L
uniprot id: U3EWX0
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9483:TAS2R38
gene id: 9483:TAS2R38
uniprot id: F7BJT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

9483:NUP155
gene id: 9483:NUP155
uniprot id: U3FK31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.
messages: nuclear pore complex

9483:TYW3
gene id: 9483:TYW3
uniprot id: U3FUS8
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9483:KIAA1191
gene id: 9483:KIAA1191
uniprot id: F7HYZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9483:LOC103795827
gene id: 9483:LOC103795827
uniprot id: F7FEM2
uniprot id: U3BWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:MIS18A
gene id: 9483:MIS18A
uniprot id: F6VMZ4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9483:VPS25
gene id: 9483:VPS25
uniprot id: U3CTP5
names: Similarity
messages: Belongs to the VPS25 family.

9483:RPL36
gene id: 9483:RPL36
uniprot id: F7IRR7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9483:GNAL
gene id: 9483:GNAL
uniprot id: F7I640
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9483:ASB11
gene id: 9483:ASB11
uniprot id: F6R7Q4
uniprot id: F6RIQ7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:LTB
gene id: 9483:LTB
uniprot id: F7I2U6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:FRG1
gene id: 9483:FRG1
uniprot id: F6QHV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9483:RRH
gene id: 9483:RRH
uniprot id: F6RXG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:SLC25A42
gene id: 9483:SLC25A42
uniprot id: F6R5T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:SERPINA6
gene id: 9483:SERPINA6
uniprot id: F7IEE1
names: Similarity
messages: Belongs to the serpin family.

9483:DOHH
gene id: 9483:DOHH
uniprot id: F7HA65
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

9483:PLAA
gene id: 9483:PLAA
uniprot id: U3CVU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9483:LOC100404859
gene id: 9483:LOC100404859
uniprot id: A0A2R8MBJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9483:SLC27A6
gene id: 9483:SLC27A6
uniprot id: F7H7P5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:PIGU
gene id: 9483:PIGU
uniprot id: A0A8J8YIQ4
uniprot id: U3EYS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:MTMR2
gene id: 9483:MTMR2
uniprot id: A0A8J8YGY6
uniprot id: U3CLW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9483:SPG7
gene id: 9483:SPG7
uniprot id: A0A2R8MB22
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9483:SMIM5
gene id: 9483:SMIM5
uniprot id: F7IM97
names: Subcellular Location Annotation
messages: Membrane

9483:RAB9A
gene id: 9483:RAB9A
uniprot id: F6QQX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9483:SLC46A3
gene id: 9483:SLC46A3
uniprot id: F7H3K0
names: Subcellular Location Annotation
messages: Membrane

9483:CRYBB1
gene id: 9483:CRYBB1
uniprot id: F7GNU3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9483:RLN2
gene id: 9483:RLN2
uniprot id: A0A2R8MSJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

9483:PTCD3
gene id: 9483:PTCD3
uniprot id: A0A8I3W350
uniprot id: F7DQG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9483:HNMT
gene id: 9483:HNMT
uniprot id: A0A2R8MUE3
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9483:IAH1
gene id: 9483:IAH1
uniprot id: F7GM17
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9483:MESD
gene id: 9483:MESD
uniprot id: A0A2R8N0D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9483:TRAF3
gene id: 9483:TRAF3
uniprot id: F7IEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9483:ASB13
gene id: 9483:ASB13
uniprot id: U3ENW7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:TAS2R4
gene id: 9483:TAS2R4
uniprot id: A0A1C9ZVV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: cilium membrane

9483:TRIM41
gene id: 9483:TRIM41
uniprot id: F7HTG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:LOC100409895
gene id: 9483:LOC100409895
uniprot id: A0A5F4VUR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TDP2
gene id: 9483:TDP2
uniprot id: F7HX74
names: Subcellular Location Annotation
messages: PML body

9483:IRAK1BP1
gene id: 9483:IRAK1BP1
uniprot id: U3CNT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9483:PSD3
gene id: 9483:PSD3
uniprot id: A0A2R8MM89
uniprot id: A0A2R8P673
uniprot id: F7I2E7
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9483:LRRC8C
gene id: 9483:LRRC8C
uniprot id: F7GH23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9483:EIF2D
gene id: 9483:EIF2D
uniprot id: F7IPX2
names: Similarity
messages: Belongs to the eIF2D family.

9483:RRAGA
gene id: 9483:RRAGA
uniprot id: U3FLU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9483:CHST10
gene id: 9483:CHST10
uniprot id: F6WIW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:SDR9C7
gene id: 9483:SDR9C7
uniprot id: F6PH06
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:MON1B
gene id: 9483:MON1B
uniprot id: F6VWD1
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9483:LOC100414342
gene id: 9483:LOC100414342
uniprot id: F7I4U5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:WDFY1
gene id: 9483:WDFY1
uniprot id: F7IMJ5
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9483:FKTN
gene id: 9483:FKTN
uniprot id: A0A8I3W7G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9483:LEP
gene id: 9483:LEP
uniprot id: F7HGW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

9483:LOC100412918
gene id: 9483:LOC100412918
uniprot id: A0A2R8ME03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:CHST9
gene id: 9483:CHST9
uniprot id: F7CJ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:ORAI2
gene id: 9483:ORAI2
uniprot id: U3FX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9483:MRPL40
gene id: 9483:MRPL40
uniprot id: U3C174
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9483:PARP8
gene id: 9483:PARP8
uniprot id: U3CCZ6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:METTL8
gene id: 9483:METTL8
uniprot id: F6W273
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9483:P4HB
gene id: 9483:P4HB
uniprot id: A0A8I3WKE0
uniprot id: U3EQL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9483:ATP6V0B
gene id: 9483:ATP6V0B
uniprot id: A0A8J8XU00
uniprot id: U3E3T0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9483:LOC100409993
gene id: 9483:LOC100409993
uniprot id: A0A8I3X651
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:ABCB7
gene id: 9483:ABCB7
uniprot id: U3DYY2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

9483:CPA3
gene id: 9483:CPA3
uniprot id: F7HXH8
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:GABRR2
gene id: 9483:GABRR2
uniprot id: A0A5F4WEQ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:STOM
gene id: 9483:STOM
uniprot id: U3ER07
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9483:OST4
gene id: 9483:OST4
uniprot id: A0A2R8M6K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:SENP5
gene id: 9483:SENP5
uniprot id: F6UAA3
uniprot id: U3CRE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9483:NTAQ1
gene id: 9483:NTAQ1
uniprot id: U3B6I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9483:CCDC124
gene id: 9483:CCDC124
uniprot id: F6URD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC124 family.
messages: Midbody

9483:ACE2
gene id: 9483:ACE2
uniprot id: F7CNJ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9483:PPP3CC
gene id: 9483:PPP3CC
uniprot id: F6ZW86
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9483:HOXD13
gene id: 9483:HOXD13
uniprot id: F7GPP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9483:TIMM23B
gene id: 9483:TIMM23B
uniprot id: F7GXV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9483:PDIK1L
gene id: 9483:PDIK1L
uniprot id: F7I2V6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:POLR1H
gene id: 9483:POLR1H
uniprot id: F7G0Q7
uniprot id: X5IYV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

9483:MTMR6
gene id: 9483:MTMR6
uniprot id: F7GSA1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9483:LOC103792189
gene id: 9483:LOC103792189
uniprot id: A0A2R8MUI6
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:RSPRY1
gene id: 9483:RSPRY1
uniprot id: F6YSF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:SDR16C5
gene id: 9483:SDR16C5
uniprot id: F6W9K3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:GABARAP
gene id: 9483:GABARAP
uniprot id: F7ANW4
names: Similarity
messages: Belongs to the ATG8 family.

9483:TMEM47
gene id: 9483:TMEM47
uniprot id: U3E0Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9483:CDIP1
gene id: 9483:CDIP1
uniprot id: U3E6P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9483:TWSG1
gene id: 9483:TWSG1
uniprot id: U3FRT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

9483:CDK6
gene id: 9483:CDK6
uniprot id: F6YF92
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:SLC8A1
gene id: 9483:SLC8A1
uniprot id: F7HA33
uniprot id: U3BXM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9483:TOMM40L
gene id: 9483:TOMM40L
uniprot id: F7F8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:DYNLT5
gene id: 9483:DYNLT5
uniprot id: F7I7T4
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9483:MPHOSPH8
gene id: 9483:MPHOSPH8
uniprot id: F7IFM1
names: Subcellular Location Annotation
messages: Nucleus

9483:HRH4
gene id: 9483:HRH4
uniprot id: F7IT43
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:CYP11B1
gene id: 9483:CYP11B1
uniprot id: A0A8I3W6Q9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:NAP1L2
gene id: 9483:NAP1L2
uniprot id: U3D3N0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:PREB
gene id: 9483:PREB
uniprot id: U3EK40
uniprot id: U3FN18
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9483:TTC39C
gene id: 9483:TTC39C
uniprot id: F6TC78
names: Similarity
messages: Belongs to the TTC39 family.

9483:ARAF
gene id: 9483:ARAF
uniprot id: A0A5K1VS71
uniprot id: U3ETY3
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9483:IPO11
gene id: 9483:IPO11
uniprot id: A0A8I3W4U3
names: Subcellular Location Annotation
messages: Cytoplasm

9483:NOP10
gene id: 9483:NOP10
uniprot id: F7GPI1
names: Similarity
messages: Belongs to the NOP10 family.

9483:ANXA10
gene id: 9483:ANXA10
uniprot id: F7IS42
names: Similarity
messages: Belongs to the annexin family.

9483:STX12
gene id: 9483:STX12
uniprot id: U3EHM2
names: Similarity
messages: Belongs to the syntaxin family.

9483:SERINC4
gene id: 9483:SERINC4
uniprot id: F6XD46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9483:RIPK2
gene id: 9483:RIPK2
uniprot id: A0A8I3WJB6
uniprot id: F7HDX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments.

9483:HDHD3
gene id: 9483:HDHD3
uniprot id: F7DX60
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9483:TMEM205
gene id: 9483:TMEM205
uniprot id: F7IAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9483:ALDH3A1
gene id: 9483:ALDH3A1
uniprot id: F6YGX5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:IFI35
gene id: 9483:IFI35
uniprot id: U3EE92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9483:ATP5PO
gene id: 9483:ATP5PO
uniprot id: B0VXH3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3 (By similarity).
messages: Belongs to the ATPase delta chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

9483:PRKG1
gene id: 9483:PRKG1
uniprot id: A0A2R8P3E2
uniprot id: U3DWF4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9483:CYP17A1
gene id: 9483:CYP17A1
uniprot id: Q5IFI0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:LARP7
gene id: 9483:LARP7
uniprot id: A0A5K1U6J8
uniprot id: U3EBY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LARP7 family.
messages: nucleoplasm

9483:ZIC1
gene id: 9483:ZIC1
uniprot id: F7IQP6
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9483:POLR3GL
gene id: 9483:POLR3GL
uniprot id: F7EJW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9483:CHN1
gene id: 9483:CHN1
uniprot id: U3FJE7
names: Function
messages: GTPase-activating protein for p21-rac.

9483:CNOT9
gene id: 9483:CNOT9
uniprot id: U3DJB7
uniprot id: U3E3W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9483:FAM174B
gene id: 9483:FAM174B
uniprot id: A0A8I3W409
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9483:SLC29A3
gene id: 9483:SLC29A3
uniprot id: F6ZJ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9483:ZNF75D
gene id: 9483:ZNF75D
uniprot id: F7III9
names: Subcellular Location Annotation
messages: Nucleus

9483:NOSIP
gene id: 9483:NOSIP
uniprot id: F7HBU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

9483:NR1I3
gene id: 9483:NR1I3
uniprot id: A0A2R8NDY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9483:SPAST
gene id: 9483:SPAST
uniprot id: A0A8I3WWX5
uniprot id: U3E3W7
uniprot id: U3ERW9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

9483:LIPK
gene id: 9483:LIPK
uniprot id: F7HHI7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9483:STOML3
gene id: 9483:STOML3
uniprot id: U3E9Z8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9483:SLC16A6
gene id: 9483:SLC16A6
uniprot id: U3E6Q4
names: Subcellular Location Annotation
messages: Membrane

9483:SORD
gene id: 9483:SORD
uniprot id: U3FKU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 1 or 2 Zn(2+) ions per subunit.
messages: Homotetramer.
messages: Mitochondrion membrane
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
messages: flagellum

9483:FBXL5
gene id: 9483:FBXL5
uniprot id: U3ER22
names: Subcellular Location Annotation
messages: perinuclear region

9483:MEFV
gene id: 9483:MEFV
uniprot id: A0A8I3WT58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:SYT16
gene id: 9483:SYT16
uniprot id: F7B0F6
names: Similarity
messages: Belongs to the synaptotagmin family.

9483:LOC100407633
gene id: 9483:LOC100407633
uniprot id: F7IFS4
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9483:HDAC5
gene id: 9483:HDAC5
uniprot id: U3CRZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9483:PEX3
gene id: 9483:PEX3
uniprot id: U3EA46
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9483:POLR2B
gene id: 9483:POLR2B
uniprot id: U3EIW2
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9483:CSTF3
gene id: 9483:CSTF3
uniprot id: F7BUE9
names: Subcellular Location Annotation
messages: Nucleus

9483:NNAT
gene id: 9483:NNAT
uniprot id: A0A2R8NBJ7
names: Similarity
messages: Belongs to the neuronatin family.

9483:PARD6B
gene id: 9483:PARD6B
uniprot id: F6RQ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9483:RPS29
gene id: 9483:RPS29
uniprot id: F7D3P5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9483:FARS2
gene id: 9483:FARS2
uniprot id: U3D2M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

9483:GGA3
gene id: 9483:GGA3
uniprot id: F7HBR1
uniprot id: F7HPW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9483:LOC100406483
gene id: 9483:LOC100406483
uniprot id: U3CIR1
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9483:CHRDL1
gene id: 9483:CHRDL1
uniprot id: F6ZC35
uniprot id: U3F7K0
names: Subcellular Location Annotation
messages: Secreted

9483:TMOD2
gene id: 9483:TMOD2
uniprot id: U3CC20
names: Subcellular Location Annotation
messages: cytoskeleton

9483:CPNE2
gene id: 9483:CPNE2
uniprot id: U3FSA6
names: Similarity
messages: Belongs to the copine family.