937775:METLIM RS03485
gene id: 937775:METLIM_RS03485
uniprot id: H1YWA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

937775:METLIM RS06525
gene id: 937775:METLIM_RS06525
uniprot id: H1Z1T8
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

937775:METLIM RS08240
gene id: 937775:METLIM_RS08240
uniprot id: H1Z464
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS05015
gene id: 937775:METLIM_RS05015
uniprot id: H1YZ85
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

937775:METLIM RS02535
gene id: 937775:METLIM_RS02535
uniprot id: H1Z2B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

937775:METLIM RS08280
gene id: 937775:METLIM_RS08280
uniprot id: H1Z472
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS14670
gene id: 937775:METLIM_RS14670
uniprot id: H1YY47
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

937775:METLIM RS09390
gene id: 937775:METLIM_RS09390
uniprot id: H1YXX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

937775:METLIM RS04880
gene id: 937775:METLIM_RS04880
uniprot id: H1YYI6
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS13660
gene id: 937775:METLIM_RS13660
uniprot id: H1YWP6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

937775:METLIM RS03590
gene id: 937775:METLIM_RS03590
uniprot id: H1YWC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

937775:METLIM RS13935
gene id: 937775:METLIM_RS13935
uniprot id: H1YWU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

937775:METLIM RS03480
gene id: 937775:METLIM_RS03480
uniprot id: H1YWA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS07945
gene id: 937775:METLIM_RS07945
uniprot id: H1Z406
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS13945
gene id: 937775:METLIM_RS13945
uniprot id: H1YWU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

937775:METLIM RS04660
gene id: 937775:METLIM_RS04660
uniprot id: H1YYF0
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

937775:METLIM RS13430
gene id: 937775:METLIM_RS13430
uniprot id: H1Z4J5
names: Similarity
messages: Belongs to the MtxX family.

937775:METLIM RS04260
gene id: 937775:METLIM_RS04260
uniprot id: H1YXK0
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS03345
gene id: 937775:METLIM_RS03345
uniprot id: H1Z3K2
names: Similarity
messages: Belongs to the peptidase S49 family.

937775:METLIM RS00435
gene id: 937775:METLIM_RS00435
uniprot id: H1YZ10
names: Similarity
messages: Belongs to the P(II) protein family.

937775:METLIM RS12855
gene id: 937775:METLIM_RS12855
uniprot id: H1Z483
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

937775:METLIM RS03730
gene id: 937775:METLIM_RS03730
uniprot id: H1YWE4
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

937775:METLIM RS03870
gene id: 937775:METLIM_RS03870
uniprot id: H1YWX1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

937775:METLIM RS11360
gene id: 937775:METLIM_RS11360
uniprot id: H1Z1I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

937775:METLIM RS06100
gene id: 937775:METLIM_RS06100
uniprot id: H1Z0Q6
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS07950
gene id: 937775:METLIM_RS07950
uniprot id: H1Z407
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

937775:METLIM RS05695
gene id: 937775:METLIM_RS05695
uniprot id: H1Z031
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS02530
gene id: 937775:METLIM_RS02530
uniprot id: H1Z2B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

937775:METLIM RS13720
gene id: 937775:METLIM_RS13720
uniprot id: H1YWQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

937775:METLIM RS05080
gene id: 937775:METLIM_RS05080
uniprot id: H1YZ96
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS04390
gene id: 937775:METLIM_RS04390
uniprot id: H1YXM6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS05780
gene id: 937775:METLIM_RS05780
uniprot id: H1Z0J7
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS15150
gene id: 937775:METLIM_RS15150
uniprot id: H1YZM2
names: Subcellular Location Annotation
messages: Cytoplasm

937775:METLIM RS04440
gene id: 937775:METLIM_RS04440
uniprot id: H1YXN6
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS05020
gene id: 937775:METLIM_RS05020
uniprot id: H1YZ86
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

937775:METLIM RS02260
gene id: 937775:METLIM_RS02260
uniprot id: H1Z1S1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

937775:METLIM RS11440
gene id: 937775:METLIM_RS11440
uniprot id: H1Z208
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

937775:METLIM RS13645
gene id: 937775:METLIM_RS13645
uniprot id: H1YWP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

937775:METLIM RS12865
gene id: 937775:METLIM_RS12865
uniprot id: H1Z485
names: Cofactor
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.

937775:METLIM RS04165
gene id: 937775:METLIM_RS04165
uniprot id: H1YX28
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

937775:METLIM RS10270
gene id: 937775:METLIM_RS10270
uniprot id: H1Z040
names: Similarity
messages: Belongs to the TrpF family.

937775:METLIM RS06990
gene id: 937775:METLIM_RS06990
uniprot id: H1Z2H0
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

937775:METLIM RS13060
gene id: 937775:METLIM_RS13060
uniprot id: H1Z4C4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

937775:METLIM RS04840
gene id: 937775:METLIM_RS04840
uniprot id: H1YYI1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

937775:METLIM RS07905
gene id: 937775:METLIM_RS07905
uniprot id: H1Z3S8
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

937775:METLIM RS06660
gene id: 937775:METLIM_RS06660
uniprot id: H1Z1W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

937775:METLIM RS12795
gene id: 937775:METLIM_RS12795
uniprot id: H1Z3Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

937775:METLIM RS11145
gene id: 937775:METLIM_RS11145
uniprot id: H1Z1E7
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS04720
gene id: 937775:METLIM_RS04720
uniprot id: H1YYG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

937775:METLIM RS08720
gene id: 937775:METLIM_RS08720
uniprot id: H1YX37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

937775:METLIM RS12745
gene id: 937775:METLIM_RS12745
uniprot id: H1Z3Y7
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

937775:METLIM RS01565
gene id: 937775:METLIM_RS01565
uniprot id: H1Z0Y9
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

937775:METLIM RS13730
gene id: 937775:METLIM_RS13730
uniprot id: H1YWR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS04815
gene id: 937775:METLIM_RS04815
uniprot id: H1YYH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

937775:METLIM RS01040
gene id: 937775:METLIM_RS01040
uniprot id: H1YZV1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

937775:METLIM RS05445
gene id: 937775:METLIM_RS05445
uniprot id: H1YZY3
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

937775:METLIM RS15070
gene id: 937775:METLIM_RS15070
uniprot id: H1YYY7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

937775:METLIM RS09395
gene id: 937775:METLIM_RS09395
uniprot id: H1YXX2
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

937775:METLIM RS00610
gene id: 937775:METLIM_RS00610
uniprot id: H1YZ43
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

937775:METLIM RS08670
gene id: 937775:METLIM_RS08670
uniprot id: H1YWM7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

937775:METLIM RS02420
gene id: 937775:METLIM_RS02420
uniprot id: H1Z297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

937775:METLIM RS06610
gene id: 937775:METLIM_RS06610
uniprot id: H1Z1V4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

937775:METLIM RS12455
gene id: 937775:METLIM_RS12455
uniprot id: H1Z3E0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS06240
gene id: 937775:METLIM_RS06240
uniprot id: H1Z174
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

937775:METLIM RS00755
gene id: 937775:METLIM_RS00755
uniprot id: H1YZ71
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

937775:METLIM RS03490
gene id: 937775:METLIM_RS03490
uniprot id: H1YWA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

937775:METLIM RS00260
gene id: 937775:METLIM_RS00260
uniprot id: H1YYA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

937775:METLIM RS13735
gene id: 937775:METLIM_RS13735
uniprot id: H1YWR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

937775:METLIM RS02355
gene id: 937775:METLIM_RS02355
uniprot id: H1Z286
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS13445
gene id: 937775:METLIM_RS13445
uniprot id: H1Z4J8
names: Similarity
messages: Belongs to the UPF0146 family.

937775:METLIM RS06940
gene id: 937775:METLIM_RS06940
uniprot id: H1Z2G0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

937775:METLIM RS07130
gene id: 937775:METLIM_RS07130
uniprot id: H1Z2J8
names: Similarity
messages: Belongs to the peptidase M3 family.

937775:METLIM RS03415
gene id: 937775:METLIM_RS03415
uniprot id: H1YW89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

937775:METLIM RS08615
gene id: 937775:METLIM_RS08615
uniprot id: H1YWL6
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

937775:METLIM RS12970
gene id: 937775:METLIM_RS12970
uniprot id: H1Z4A6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

937775:METLIM RS11305
gene id: 937775:METLIM_RS11305
uniprot id: H1Z1H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

937775:METLIM RS03725
gene id: 937775:METLIM_RS03725
uniprot id: H1YWE3
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

937775:METLIM RS10025
gene id: 937775:METLIM_RS10025
uniprot id: H1YZI0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

937775:METLIM RS11285
gene id: 937775:METLIM_RS11285
uniprot id: H1Z1H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

937775:METLIM RS11470
gene id: 937775:METLIM_RS11470
uniprot id: H1Z215
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

937775:METLIM RS04110
gene id: 937775:METLIM_RS04110
uniprot id: H1YX17
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS02625
gene id: 937775:METLIM_RS02625
uniprot id: H1Z2D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

937775:METLIM RS12550
gene id: 937775:METLIM_RS12550
uniprot id: H1Z3V2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

937775:METLIM RS04685
gene id: 937775:METLIM_RS04685
uniprot id: H1YYF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

937775:METLIM RS13860
gene id: 937775:METLIM_RS13860
uniprot id: H1YWT1
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

937775:METLIM RS13245
gene id: 937775:METLIM_RS13245
uniprot id: H1Z4F7
names: Similarity
messages: Belongs to the UPF0212 family.

937775:METLIM RS03465
gene id: 937775:METLIM_RS03465
uniprot id: H1YW98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

937775:METLIM RS09870
gene id: 937775:METLIM_RS09870
uniprot id: H1YZF1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

937775:METLIM RS07880
gene id: 937775:METLIM_RS07880
uniprot id: H1Z3S3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

937775:METLIM RS10350
gene id: 937775:METLIM_RS10350
uniprot id: H1Z058
names: Similarity
messages: Belongs to the glutamine synthetase family.

937775:METLIM RS12365
gene id: 937775:METLIM_RS12365
uniprot id: H1Z3C3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS04710
gene id: 937775:METLIM_RS04710
uniprot id: H1YYF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

937775:METLIM RS04030
gene id: 937775:METLIM_RS04030
uniprot id: H1YX02
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

937775:METLIM RS02450
gene id: 937775:METLIM_RS02450
uniprot id: H1Z2A2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

937775:METLIM RS13885
gene id: 937775:METLIM_RS13885
uniprot id: H1YWT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

937775:METLIM RS05365
gene id: 937775:METLIM_RS05365
uniprot id: H1YZW6
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS13420
gene id: 937775:METLIM_RS13420
uniprot id: H1Z4J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

937775:METLIM RS10920
gene id: 937775:METLIM_RS10920
uniprot id: H1Z0W2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS07955
gene id: 937775:METLIM_RS07955
uniprot id: H1Z408
names: Similarity
messages: Belongs to the catalase family.

937775:METLIM RS14895
gene id: 937775:METLIM_RS14895
uniprot id: H1YYV2
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS13770
gene id: 937775:METLIM_RS13770
uniprot id: H1YWR8
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

937775:METLIM RS14455
gene id: 937775:METLIM_RS14455
uniprot id: H1YY03
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS14330
gene id: 937775:METLIM_RS14330
uniprot id: H1YXH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

937775:METLIM RS09505
gene id: 937775:METLIM_RS09505
uniprot id: H1YYL0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

937775:METLIM RS07820
gene id: 937775:METLIM_RS07820
uniprot id: H1Z3R1
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS00070
gene id: 937775:METLIM_RS00070
uniprot id: H1YY70
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

937775:METLIM RS03280
gene id: 937775:METLIM_RS03280
uniprot id: H1Z3I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

937775:METLIM RS14595
gene id: 937775:METLIM_RS14595
uniprot id: H1YY32
names: Similarity
messages: Belongs to the HdrC family.

937775:METLIM RS06795
gene id: 937775:METLIM_RS06795
uniprot id: H1Z1Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

937775:METLIM RS04360
gene id: 937775:METLIM_RS04360
uniprot id: H1YXM0
names: Similarity
messages: Belongs to the UPF0111 family.

937775:METLIM RS03680
gene id: 937775:METLIM_RS03680
uniprot id: H1YWD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

937775:METLIM RS08135
gene id: 937775:METLIM_RS08135
uniprot id: H1Z443
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS11090
gene id: 937775:METLIM_RS11090
uniprot id: H1Z1D6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

937775:METLIM RS04905
gene id: 937775:METLIM_RS04905
uniprot id: H1YYJ1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

937775:METLIM RS05590
gene id: 937775:METLIM_RS05590
uniprot id: H1Z009
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

937775:METLIM RS11020
gene id: 937775:METLIM_RS11020
uniprot id: H1Z1C3
names: Similarity
messages: Belongs to the HsdR family.

937775:METLIM RS04315
gene id: 937775:METLIM_RS04315
uniprot id: H1YXL1
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

937775:METLIM RS05775
gene id: 937775:METLIM_RS05775
uniprot id: H1Z0J6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS06075
gene id: 937775:METLIM_RS06075
uniprot id: H1Z0Q0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

937775:METLIM RS15425
gene id: 937775:METLIM_RS15425
uniprot id: H1YYD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

937775:METLIM RS15670
gene id: 937775:METLIM_RS15670
uniprot id: H1Z043
names: Similarity
messages: Belongs to the peptidase C1 family.

937775:METLIM RS09060
gene id: 937775:METLIM_RS09060
uniprot id: H1YXA5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

937775:METLIM RS04515
gene id: 937775:METLIM_RS04515
uniprot id: H1YXQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

937775:METLIM RS02930
gene id: 937775:METLIM_RS02930
uniprot id: H1Z2Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

937775:METLIM RS01695
gene id: 937775:METLIM_RS01695
uniprot id: H1Z114
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS02840
gene id: 937775:METLIM_RS02840
uniprot id: H1Z2W5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

937775:METLIM RS15655
gene id: 937775:METLIM_RS15655
uniprot id: H1YZK2
names: Similarity
messages: Belongs to the peptidase S8 family.

937775:METLIM RS14005
gene id: 937775:METLIM_RS14005
uniprot id: H1YXB3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

937775:METLIM RS12895
gene id: 937775:METLIM_RS12895
uniprot id: H1Z491
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

937775:METLIM RS11100
gene id: 937775:METLIM_RS11100
uniprot id: H1Z1D8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

937775:METLIM RS08640
gene id: 937775:METLIM_RS08640
uniprot id: H1YWM1
names: Similarity
messages: Belongs to the UPF0179 family.

937775:METLIM RS10235
gene id: 937775:METLIM_RS10235
uniprot id: H1YZL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

937775:METLIM RS07845
gene id: 937775:METLIM_RS07845
uniprot id: H1Z3R6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS13855
gene id: 937775:METLIM_RS13855
uniprot id: H1YWT0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

937775:METLIM RS07010
gene id: 937775:METLIM_RS07010
uniprot id: H1Z2H4
names: Similarity
messages: Belongs to the UPF0305 family.

937775:METLIM RS01700
gene id: 937775:METLIM_RS01700
uniprot id: H1Z115
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS06180
gene id: 937775:METLIM_RS06180
uniprot id: H1Z162
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

937775:METLIM RS12765
gene id: 937775:METLIM_RS12765
uniprot id: H1Z3Z1
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

937775:METLIM RS04825
gene id: 937775:METLIM_RS04825
uniprot id: H1YYH8
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS03365
gene id: 937775:METLIM_RS03365
uniprot id: H1Z3K6
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

937775:METLIM RS07860
gene id: 937775:METLIM_RS07860
uniprot id: H1Z3R9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

937775:METLIM RS03355
gene id: 937775:METLIM_RS03355
uniprot id: H1Z3K4
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

937775:METLIM RS02920
gene id: 937775:METLIM_RS02920
uniprot id: H1Z2Y1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

937775:METLIM RS07920
gene id: 937775:METLIM_RS07920
uniprot id: H1Z3T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

937775:METLIM RS02160
gene id: 937775:METLIM_RS02160
uniprot id: H1Z1Q2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS06190
gene id: 937775:METLIM_RS06190
uniprot id: H1Z164
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

937775:METLIM RS15800
gene id: 937775:METLIM_RS15800
uniprot id: H1Z3B7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS13355
gene id: 937775:METLIM_RS13355
uniprot id: H1Z4H9
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

937775:METLIM RS08490
gene id: 937775:METLIM_RS08490
uniprot id: H1YWJ3
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS08130
gene id: 937775:METLIM_RS08130
uniprot id: H1Z442
names: Similarity
messages: Belongs to the UPF0288 family.

937775:METLIM RS11460
gene id: 937775:METLIM_RS11460
uniprot id: H1Z213
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

937775:METLIM RS02305
gene id: 937775:METLIM_RS02305
uniprot id: H1Z276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

937775:METLIM RS11095
gene id: 937775:METLIM_RS11095
uniprot id: H1Z1D7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS05930
gene id: 937775:METLIM_RS05930
uniprot id: H1Z0M5
names: Similarity
messages: Belongs to the OMP decarboxylase family.

937775:METLIM RS11665
gene id: 937775:METLIM_RS11665
uniprot id: H1Z253
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

937775:METLIM RS09050
gene id: 937775:METLIM_RS09050
uniprot id: H1YXA3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

937775:METLIM RS12945
gene id: 937775:METLIM_RS12945
uniprot id: H1Z4A1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

937775:METLIM RS06890
gene id: 937775:METLIM_RS06890
uniprot id: H1Z2F0
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

937775:METLIM RS07135
gene id: 937775:METLIM_RS07135
uniprot id: H1Z2J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

937775:METLIM RS04195
gene id: 937775:METLIM_RS04195
uniprot id: H1YXI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

937775:METLIM RS11450
gene id: 937775:METLIM_RS11450
uniprot id: H1Z211
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

937775:METLIM RS02545
gene id: 937775:METLIM_RS02545
uniprot id: H1Z2B8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

937775:METLIM RS14390
gene id: 937775:METLIM_RS14390
uniprot id: H1YXZ2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

937775:METLIM RS02370
gene id: 937775:METLIM_RS02370
uniprot id: H1Z289
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS07915
gene id: 937775:METLIM_RS07915
uniprot id: H1Z3T0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

937775:METLIM RS05360
gene id: 937775:METLIM_RS05360
uniprot id: H1YZW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

937775:METLIM RS04395
gene id: 937775:METLIM_RS04395
uniprot id: H1YXM7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

937775:METLIM RS00400
gene id: 937775:METLIM_RS00400
uniprot id: H1YZ03
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

937775:METLIM RS09330
gene id: 937775:METLIM_RS09330
uniprot id: H1YXV9
names: Subunit
messages: Homotetramer.

937775:METLIM RS04380
gene id: 937775:METLIM_RS04380
uniprot id: H1YXM4
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

937775:METLIM RS05820
gene id: 937775:METLIM_RS05820
uniprot id: H1Z0K4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS08705
gene id: 937775:METLIM_RS08705
uniprot id: H1YX34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

937775:METLIM RS11350
gene id: 937775:METLIM_RS11350
uniprot id: H1Z1I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

937775:METLIM RS00040
gene id: 937775:METLIM_RS00040
uniprot id: H1YY64
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

937775:METLIM RS00570
gene id: 937775:METLIM_RS00570
uniprot id: H1YZ36
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

937775:METLIM RS05895
gene id: 937775:METLIM_RS05895
uniprot id: H1Z0L7
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS01590
gene id: 937775:METLIM_RS01590
uniprot id: H1Z0Z4
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

937775:METLIM RS02340
gene id: 937775:METLIM_RS02340
uniprot id: H1Z283
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

937775:METLIM RS03690
gene id: 937775:METLIM_RS03690
uniprot id: H1YWD6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

937775:METLIM RS06770
gene id: 937775:METLIM_RS06770
uniprot id: H1Z1Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

937775:METLIM RS14385
gene id: 937775:METLIM_RS14385
uniprot id: H1YXZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

937775:METLIM RS06090
gene id: 937775:METLIM_RS06090
uniprot id: H1Z0Q4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

937775:METLIM RS07330
gene id: 937775:METLIM_RS07330
uniprot id: H1Z324
names: Similarity
messages: Belongs to the ZPR1 family.

937775:METLIM RS06545
gene id: 937775:METLIM_RS06545
uniprot id: H1Z1U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

937775:METLIM RS12805
gene id: 937775:METLIM_RS12805
uniprot id: H1Z3Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

937775:METLIM RS13240
gene id: 937775:METLIM_RS13240
uniprot id: H1Z4F6
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

937775:METLIM RS12145
gene id: 937775:METLIM_RS12145
uniprot id: H1Z379
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

937775:METLIM RS12755
gene id: 937775:METLIM_RS12755
uniprot id: H1Z3Y9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

937775:METLIM RS13795
gene id: 937775:METLIM_RS13795
uniprot id: H1YWS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

937775:METLIM RS13680
gene id: 937775:METLIM_RS13680
uniprot id: H1YWQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

937775:METLIM RS00055
gene id: 937775:METLIM_RS00055
uniprot id: H1YY67
names: Similarity
messages: Belongs to the HMBS family.

937775:METLIM RS07250
gene id: 937775:METLIM_RS07250
uniprot id: H1Z309
names: Similarity
messages: Belongs to the group II decarboxylase family.

937775:METLIM RS06655
gene id: 937775:METLIM_RS06655
uniprot id: H1Z1W3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS06150
gene id: 937775:METLIM_RS06150
uniprot id: H1Z156
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

937775:METLIM RS05305
gene id: 937775:METLIM_RS05305
uniprot id: H1YZD7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

937775:METLIM RS12810
gene id: 937775:METLIM_RS12810
uniprot id: H1Z400
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

937775:METLIM RS03070
gene id: 937775:METLIM_RS03070
uniprot id: H1Z3F3
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

937775:METLIM RS06925
gene id: 937775:METLIM_RS06925
uniprot id: H1Z2F7
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS06420
gene id: 937775:METLIM_RS06420
uniprot id: H1Z1B6
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

937775:METLIM RS01185
gene id: 937775:METLIM_RS01185
uniprot id: H1Z0C2
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS13115
gene id: 937775:METLIM_RS13115
uniprot id: H1Z4D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

937775:METLIM RS08345
gene id: 937775:METLIM_RS08345
uniprot id: H1YWG3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

937775:METLIM RS13715
gene id: 937775:METLIM_RS13715
uniprot id: H1YWQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS14845
gene id: 937775:METLIM_RS14845
uniprot id: H1YYU3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

937775:METLIM RS07350
gene id: 937775:METLIM_RS07350
uniprot id: H1Z328
names: Similarity
messages: Belongs to the aspartokinase family.

937775:METLIM RS05595
gene id: 937775:METLIM_RS05595
uniprot id: H1Z010
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

937775:METLIM RS12930
gene id: 937775:METLIM_RS12930
uniprot id: H1Z498
names: Subcellular Location Annotation
messages: Cytoplasm

937775:METLIM RS14300
gene id: 937775:METLIM_RS14300
uniprot id: H1YXH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Belongs to the MtrG family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

937775:METLIM RS13630
gene id: 937775:METLIM_RS13630
uniprot id: H1YWP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

937775:METLIM RS13880
gene id: 937775:METLIM_RS13880
uniprot id: H1YWT5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

937775:METLIM RS06715
gene id: 937775:METLIM_RS06715
uniprot id: H1Z1X5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

937775:METLIM RS01860
gene id: 937775:METLIM_RS01860
uniprot id: H1Z1J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

937775:METLIM RS04145
gene id: 937775:METLIM_RS04145
uniprot id: H1YX24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

937775:METLIM RS01755
gene id: 937775:METLIM_RS01755
uniprot id: H1Z126
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

937775:METLIM RS15205
gene id: 937775:METLIM_RS15205
uniprot id: H1YZN3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

937775:METLIM RS03640
gene id: 937775:METLIM_RS03640
uniprot id: H1YWC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS01645
gene id: 937775:METLIM_RS01645
uniprot id: H1Z103
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

937775:METLIM RS05120
gene id: 937775:METLIM_RS05120
uniprot id: H1YZA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

937775:METLIM RS03045
gene id: 937775:METLIM_RS03045
uniprot id: H1Z3E9
names: Similarity
messages: Belongs to the NadC/ModD family.

937775:METLIM RS12015
gene id: 937775:METLIM_RS12015
uniprot id: H1Z2R8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

937775:METLIM RS13365
gene id: 937775:METLIM_RS13365
uniprot id: H1Z4I2
names: Similarity
messages: Belongs to the class-I fumarase family.

937775:METLIM RS12990
gene id: 937775:METLIM_RS12990
uniprot id: H1Z4B0
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

937775:METLIM RS03630
gene id: 937775:METLIM_RS03630
uniprot id: H1YWC5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

937775:METLIM RS03920
gene id: 937775:METLIM_RS03920
uniprot id: H1YWY1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

937775:METLIM RS05440
gene id: 937775:METLIM_RS05440
uniprot id: H1YZY2
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

937775:METLIM RS14870
gene id: 937775:METLIM_RS14870
uniprot id: H1YYU8
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS00480
gene id: 937775:METLIM_RS00480
uniprot id: H1YZ18
names: Similarity
messages: Belongs to the glutamate synthase family.

937775:METLIM RS13265
gene id: 937775:METLIM_RS13265
uniprot id: H1Z4G1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

937775:METLIM RS04700
gene id: 937775:METLIM_RS04700
uniprot id: H1YYF7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS00730
gene id: 937775:METLIM_RS00730
uniprot id: H1YZ66
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS14320
gene id: 937775:METLIM_RS14320
uniprot id: H1YXH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

937775:METLIM RS00290
gene id: 937775:METLIM_RS00290
uniprot id: H1YYB4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

937775:METLIM RS04140
gene id: 937775:METLIM_RS04140
uniprot id: H1YX23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

937775:METLIM RS05925
gene id: 937775:METLIM_RS05925
uniprot id: H1Z0M4
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

937775:METLIM RS08455
gene id: 937775:METLIM_RS08455
uniprot id: H1YWI6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

937775:METLIM RS14850
gene id: 937775:METLIM_RS14850
uniprot id: H1YYU4
names: Similarity
messages: Belongs to the UPF0305 family.

937775:METLIM RS02630
gene id: 937775:METLIM_RS02630
uniprot id: H1Z2D4
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

937775:METLIM RS03755
gene id: 937775:METLIM_RS03755
uniprot id: H1YWE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

937775:METLIM RS05330
gene id: 937775:METLIM_RS05330
uniprot id: H1YZE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

937775:METLIM RS01575
gene id: 937775:METLIM_RS01575
uniprot id: H1Z0Z1
names: Similarity
messages: Belongs to the TrpF family.

937775:METLIM RS04695
gene id: 937775:METLIM_RS04695
uniprot id: H1YYF6
names: Similarity
messages: Belongs to the acylphosphatase family.

937775:METLIM RS13650
gene id: 937775:METLIM_RS13650
uniprot id: H1YWP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

937775:METLIM RS10585
gene id: 937775:METLIM_RS10585
uniprot id: H1Z0A4
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

937775:METLIM RS05730
gene id: 937775:METLIM_RS05730
uniprot id: H1Z0I8
names: Similarity
messages: Belongs to the carbamate kinase family.

937775:METLIM RS13280
gene id: 937775:METLIM_RS13280
uniprot id: H1Z4G4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS08870
gene id: 937775:METLIM_RS08870
uniprot id: H1YX66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

937775:METLIM RS11420
gene id: 937775:METLIM_RS11420
uniprot id: H1Z203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

937775:METLIM RS14080
gene id: 937775:METLIM_RS14080
uniprot id: H1YXC8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

937775:METLIM RS02170
gene id: 937775:METLIM_RS02170
uniprot id: H1Z1Q4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS03385
gene id: 937775:METLIM_RS03385
uniprot id: H1YW83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

937775:METLIM RS05585
gene id: 937775:METLIM_RS05585
uniprot id: H1Z008
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

937775:METLIM RS00490
gene id: 937775:METLIM_RS00490
uniprot id: H1YZ20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

937775:METLIM RS04045
gene id: 937775:METLIM_RS04045
uniprot id: H1YX05
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

937775:METLIM RS06820
gene id: 937775:METLIM_RS06820
uniprot id: H1Z1Z6
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS14745
gene id: 937775:METLIM_RS14745
uniprot id: H1YYS4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

937775:METLIM RS09290
gene id: 937775:METLIM_RS09290
uniprot id: H1YXV1
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

937775:METLIM RS00600
gene id: 937775:METLIM_RS00600
uniprot id: H1YZ41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

937775:METLIM RS02495
gene id: 937775:METLIM_RS02495
uniprot id: H1Z2A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

937775:METLIM RS05040
gene id: 937775:METLIM_RS05040
uniprot id: H1YZ89
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

937775:METLIM RS07150
gene id: 937775:METLIM_RS07150
uniprot id: H1Z2K1
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS04505
gene id: 937775:METLIM_RS04505
uniprot id: H1YXP8
names: Similarity
messages: Belongs to the AAA ATPase family.

937775:METLIM RS13940
gene id: 937775:METLIM_RS13940
uniprot id: H1YWU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

937775:METLIM RS04150
gene id: 937775:METLIM_RS04150
uniprot id: H1YX25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

937775:METLIM RS04100
gene id: 937775:METLIM_RS04100
uniprot id: H1YX15
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS13325
gene id: 937775:METLIM_RS13325
uniprot id: H1Z4H3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

937775:METLIM RS03585
gene id: 937775:METLIM_RS03585
uniprot id: H1YWC0
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS15595
gene id: 937775:METLIM_RS15595
uniprot id: H1YX88
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS03295
gene id: 937775:METLIM_RS03295
uniprot id: H1Z3J2
names: Similarity
messages: Belongs to the UPF0147 family.

937775:METLIM RS04185
gene id: 937775:METLIM_RS04185
uniprot id: H1YXI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

937775:METLIM RS14195
gene id: 937775:METLIM_RS14195
uniprot id: H1YXF1
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

937775:METLIM RS03455
gene id: 937775:METLIM_RS03455
uniprot id: H1YW96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

937775:METLIM RS03890
gene id: 937775:METLIM_RS03890
uniprot id: H1YWX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

937775:METLIM RS07835
gene id: 937775:METLIM_RS07835
uniprot id: H1Z3R4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS04050
gene id: 937775:METLIM_RS04050
uniprot id: H1YX06
names: Similarity
messages: Belongs to the phosphohexose mutase family.

937775:METLIM RS01735
gene id: 937775:METLIM_RS01735
uniprot id: H1Z122
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

937775:METLIM RS13700
gene id: 937775:METLIM_RS13700
uniprot id: H1YWQ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

937775:METLIM RS09810
gene id: 937775:METLIM_RS09810
uniprot id: H1YYR4
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS08485
gene id: 937775:METLIM_RS08485
uniprot id: H1YWJ2
names: Similarity
messages: Belongs to the SUI1 family.

937775:METLIM RS06735
gene id: 937775:METLIM_RS06735
uniprot id: H1Z1X9
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS08265
gene id: 937775:METLIM_RS08265
uniprot id: H1Z469
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS08860
gene id: 937775:METLIM_RS08860
uniprot id: H1YX64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

937775:METLIM RS06845
gene id: 937775:METLIM_RS06845
uniprot id: H1Z2E2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

937775:METLIM RS05045
gene id: 937775:METLIM_RS05045
uniprot id: H1YZ90
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

937775:METLIM RS08340
gene id: 937775:METLIM_RS08340
uniprot id: H1YWG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

937775:METLIM RS03885
gene id: 937775:METLIM_RS03885
uniprot id: H1YWX4
names: Similarity
messages: Belongs to the PurH family.

937775:METLIM RS14820
gene id: 937775:METLIM_RS14820
uniprot id: H1YYT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

937775:METLIM RS09960
gene id: 937775:METLIM_RS09960
uniprot id: H1YZH0
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

937775:METLIM RS12475
gene id: 937775:METLIM_RS12475
uniprot id: H1Z3T7
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS14765
gene id: 937775:METLIM_RS14765
uniprot id: H1YYS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

937775:METLIM RS13335
gene id: 937775:METLIM_RS13335
uniprot id: H1Z4H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

937775:METLIM RS00555
gene id: 937775:METLIM_RS00555
uniprot id: H1YZ33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

937775:METLIM RS03200
gene id: 937775:METLIM_RS03200
uniprot id: H1Z3H3
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS06740
gene id: 937775:METLIM_RS06740
uniprot id: H1Z1Y0
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS04470
gene id: 937775:METLIM_RS04470
uniprot id: H1YXP2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

937775:METLIM RS13360
gene id: 937775:METLIM_RS13360
uniprot id: H1Z4I1
names: Similarity
messages: Belongs to the class-I fumarase family.

937775:METLIM RS05410
gene id: 937775:METLIM_RS05410
uniprot id: H1YZX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

937775:METLIM RS02520
gene id: 937775:METLIM_RS02520
uniprot id: H1Z2B3
names: Similarity
messages: Belongs to the SDO1/SBDS family.

937775:METLIM RS04780
gene id: 937775:METLIM_RS04780
uniprot id: H1YYH1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

937775:METLIM RS04170
gene id: 937775:METLIM_RS04170
uniprot id: H1YX29
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS00330
gene id: 937775:METLIM_RS00330
uniprot id: H1YYC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

937775:METLIM RS14135
gene id: 937775:METLIM_RS14135
uniprot id: H1YXD9
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

937775:METLIM RS06595
gene id: 937775:METLIM_RS06595
uniprot id: H1Z1V1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

937775:METLIM RS02525
gene id: 937775:METLIM_RS02525
uniprot id: H1Z2B4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

937775:METLIM RS07970
gene id: 937775:METLIM_RS07970
uniprot id: H1Z411
names: Similarity
messages: Belongs to the Ahb/Nir family.

937775:METLIM RS04865
gene id: 937775:METLIM_RS04865
uniprot id: H1YYI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

937775:METLIM RS00650
gene id: 937775:METLIM_RS00650
uniprot id: H1YZ50
names: Similarity
messages: Belongs to the HypE family.

937775:METLIM RS12905
gene id: 937775:METLIM_RS12905
uniprot id: H1Z493
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS02905
gene id: 937775:METLIM_RS02905
uniprot id: H1Z2X9
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

937775:METLIM RS07940
gene id: 937775:METLIM_RS07940
uniprot id: H1Z405
names: Similarity
messages: Belongs to the helicase family. RAD3/XPD subfamily.

937775:METLIM RS13840
gene id: 937775:METLIM_RS13840
uniprot id: H1YWS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

937775:METLIM RS08360
gene id: 937775:METLIM_RS08360
uniprot id: H1YWG6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

937775:METLIM RS11430
gene id: 937775:METLIM_RS11430
uniprot id: H1Z205
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS00470
gene id: 937775:METLIM_RS00470
uniprot id: H1YZ16
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

937775:METLIM RS12080
gene id: 937775:METLIM_RS12080
uniprot id: H1Z2S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

937775:METLIM RS08270
gene id: 937775:METLIM_RS08270
uniprot id: H1Z470
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

937775:METLIM RS12790
gene id: 937775:METLIM_RS12790
uniprot id: H1Z3Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

937775:METLIM RS13120
gene id: 937775:METLIM_RS13120
uniprot id: H1Z4D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

937775:METLIM RS13760
gene id: 937775:METLIM_RS13760
uniprot id: H1YWR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

937775:METLIM RS10275
gene id: 937775:METLIM_RS10275
uniprot id: H1Z041
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

937775:METLIM RS00530
gene id: 937775:METLIM_RS00530
uniprot id: H1YZ28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

937775:METLIM RS09845
gene id: 937775:METLIM_RS09845
uniprot id: H1YZE6
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

937775:METLIM RS02165
gene id: 937775:METLIM_RS02165
uniprot id: H1Z1Q3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

937775:METLIM RS00335
gene id: 937775:METLIM_RS00335
uniprot id: H1YYC4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

937775:METLIM RS09265
gene id: 937775:METLIM_RS09265
uniprot id: H1YXU6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

937775:METLIM RS08025
gene id: 937775:METLIM_RS08025
uniprot id: H1Z421
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS15590
gene id: 937775:METLIM_RS15590
uniprot id: H1YX79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS00320
gene id: 937775:METLIM_RS00320
uniprot id: H1YYC1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS12715
gene id: 937775:METLIM_RS12715
uniprot id: H1Z3Y3
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS04500
gene id: 937775:METLIM_RS04500
uniprot id: H1YXP7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

937775:METLIM RS12510
gene id: 937775:METLIM_RS12510
uniprot id: H1Z3U4
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

937775:METLIM RS08165
gene id: 937775:METLIM_RS08165
uniprot id: H1Z449
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

937775:METLIM RS13690
gene id: 937775:METLIM_RS13690
uniprot id: H1YWQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS02880
gene id: 937775:METLIM_RS02880
uniprot id: H1Z2X4
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS06165
gene id: 937775:METLIM_RS06165
uniprot id: H1Z159
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

937775:METLIM RS12525
gene id: 937775:METLIM_RS12525
uniprot id: H1Z3U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

937775:METLIM RS00085
gene id: 937775:METLIM_RS00085
uniprot id: H1YY73
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS13725
gene id: 937775:METLIM_RS13725
uniprot id: H1YWQ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

937775:METLIM RS02125
gene id: 937775:METLIM_RS02125
uniprot id: H1Z1P5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

937775:METLIM RS07930
gene id: 937775:METLIM_RS07930
uniprot id: H1Z3T3
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

937775:METLIM RS04350
gene id: 937775:METLIM_RS04350
uniprot id: H1YXL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

937775:METLIM RS10345
gene id: 937775:METLIM_RS10345
uniprot id: H1Z057
names: Similarity
messages: Belongs to the NodU/CmcH family.

937775:METLIM RS03795
gene id: 937775:METLIM_RS03795
uniprot id: H1YWV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

937775:METLIM RS14150
gene id: 937775:METLIM_RS14150
uniprot id: H1YXE2
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

937775:METLIM RS00575
gene id: 937775:METLIM_RS00575
uniprot id: H1YZ37
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

937775:METLIM RS05320
gene id: 937775:METLIM_RS05320
uniprot id: H1YZE0
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

937775:METLIM RS07925
gene id: 937775:METLIM_RS07925
uniprot id: H1Z3T2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

937775:METLIM RS11455
gene id: 937775:METLIM_RS11455
uniprot id: H1Z212
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

937775:METLIM RS11640
gene id: 937775:METLIM_RS11640
uniprot id: H1Z249
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS14170
gene id: 937775:METLIM_RS14170
uniprot id: H1YXE6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

937775:METLIM RS03360
gene id: 937775:METLIM_RS03360
uniprot id: H1Z3K5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS06225
gene id: 937775:METLIM_RS06225
uniprot id: H1Z171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

937775:METLIM RS12830
gene id: 937775:METLIM_RS12830
uniprot id: H1Z478
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

937775:METLIM RS08635
gene id: 937775:METLIM_RS08635
uniprot id: H1YWM0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

937775:METLIM RS08050
gene id: 937775:METLIM_RS08050
uniprot id: H1Z426
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

937775:METLIM RS07485
gene id: 937775:METLIM_RS07485
uniprot id: H1Z352
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS02655
gene id: 937775:METLIM_RS02655
uniprot id: H1Z2D8
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

937775:METLIM RS14410
gene id: 937775:METLIM_RS14410
uniprot id: H1YXZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS04970
gene id: 937775:METLIM_RS04970
uniprot id: H1YZ76
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

937775:METLIM RS00645
gene id: 937775:METLIM_RS00645
uniprot id: H1YZ49
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

937775:METLIM RS02510
gene id: 937775:METLIM_RS02510
uniprot id: H1Z2B1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

937775:METLIM RS12880
gene id: 937775:METLIM_RS12880
uniprot id: H1Z488
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

937775:METLIM RS04340
gene id: 937775:METLIM_RS04340
uniprot id: H1YXL6
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

937775:METLIM RS10595
gene id: 937775:METLIM_RS10595
uniprot id: H1Z0A6
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

937775:METLIM RS05710
gene id: 937775:METLIM_RS05710
uniprot id: H1Z034
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

937775:METLIM RS01135
gene id: 937775:METLIM_RS01135
uniprot id: H1Z0B2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

937775:METLIM RS05990
gene id: 937775:METLIM_RS05990
uniprot id: H1Z0N5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS00560
gene id: 937775:METLIM_RS00560
uniprot id: H1YZ34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

937775:METLIM RS12885
gene id: 937775:METLIM_RS12885
uniprot id: H1Z489
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

937775:METLIM RS09350
gene id: 937775:METLIM_RS09350
uniprot id: H1YXW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

937775:METLIM RS11625
gene id: 937775:METLIM_RS11625
uniprot id: H1Z246
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

937775:METLIM RS14255
gene id: 937775:METLIM_RS14255
uniprot id: H1YXG4
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

937775:METLIM RS15120
gene id: 937775:METLIM_RS15120
uniprot id: H1YYZ7
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

937775:METLIM RS04715
gene id: 937775:METLIM_RS04715
uniprot id: H1YYG0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS04040
gene id: 937775:METLIM_RS04040
uniprot id: H1YX04
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

937775:METLIM RS01200
gene id: 937775:METLIM_RS01200
uniprot id: H1Z0C5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

937775:METLIM RS12675
gene id: 937775:METLIM_RS12675
uniprot id: H1Z3X5
names: Similarity
messages: Belongs to the leucine-binding protein family.

937775:METLIM RS14555
gene id: 937775:METLIM_RS14555
uniprot id: H1YY23
names: Similarity
messages: Belongs to the FwdC/FmdC family.

937775:METLIM RS08750
gene id: 937775:METLIM_RS08750
uniprot id: H1YX43
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

937775:METLIM RS08420
gene id: 937775:METLIM_RS08420
uniprot id: H1YWH9
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS07890
gene id: 937775:METLIM_RS07890
uniprot id: H1Z3S5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

937775:METLIM RS12390
gene id: 937775:METLIM_RS12390
uniprot id: H1Z3C8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS08895
gene id: 937775:METLIM_RS08895
uniprot id: H1YX71
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

937775:METLIM RS12085
gene id: 937775:METLIM_RS12085
uniprot id: H1Z368
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

937775:METLIM RS06205
gene id: 937775:METLIM_RS06205
uniprot id: H1Z167
names: Similarity
messages: Belongs to the UPF0285 family.

937775:METLIM RS02540
gene id: 937775:METLIM_RS02540
uniprot id: H1Z2B7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

937775:METLIM RS03565
gene id: 937775:METLIM_RS03565
uniprot id: H1YWB6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS09300
gene id: 937775:METLIM_RS09300
uniprot id: H1YXV3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS00660
gene id: 937775:METLIM_RS00660
uniprot id: H1YZ52
names: Similarity
messages: Belongs to the UPF0235 family.

937775:METLIM RS12150
gene id: 937775:METLIM_RS12150
uniprot id: H1Z381
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS09035
gene id: 937775:METLIM_RS09035
uniprot id: H1YX99
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS14120
gene id: 937775:METLIM_RS14120
uniprot id: H1YXD6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS08370
gene id: 937775:METLIM_RS08370
uniprot id: H1YWG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

937775:METLIM RS03875
gene id: 937775:METLIM_RS03875
uniprot id: H1YWX2
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

937775:METLIM RS04535
gene id: 937775:METLIM_RS04535
uniprot id: H1YXQ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

937775:METLIM RS07455
gene id: 937775:METLIM_RS07455
uniprot id: H1Z346
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

937775:METLIM RS02105
gene id: 937775:METLIM_RS02105
uniprot id: H1Z1P1
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS00845
gene id: 937775:METLIM_RS00845
uniprot id: H1YZQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane
messages: Membrane

937775:METLIM RS03825
gene id: 937775:METLIM_RS03825
uniprot id: H1YWW2
names: Similarity
messages: Belongs to the UPF0284 family.

937775:METLIM RS00155
gene id: 937775:METLIM_RS00155
uniprot id: H1YY87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

937775:METLIM RS07850
gene id: 937775:METLIM_RS07850
uniprot id: H1Z3R7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS04270
gene id: 937775:METLIM_RS04270
uniprot id: H1YXK2
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

937775:METLIM RS08815
gene id: 937775:METLIM_RS08815
uniprot id: H1YX56
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

937775:METLIM RS06425
gene id: 937775:METLIM_RS06425
uniprot id: H1Z1B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

937775:METLIM RS13750
gene id: 937775:METLIM_RS13750
uniprot id: H1YWR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

937775:METLIM RS03375
gene id: 937775:METLIM_RS03375
uniprot id: H1Z3K8
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS01230
gene id: 937775:METLIM_RS01230
uniprot id: H1Z0D1
names: Similarity
messages: Belongs to the polysaccharide synthase family.

937775:METLIM RS08155
gene id: 937775:METLIM_RS08155
uniprot id: H1Z447
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

937775:METLIM RS03055
gene id: 937775:METLIM_RS03055
uniprot id: H1Z3F1
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

937775:METLIM RS04365
gene id: 937775:METLIM_RS04365
uniprot id: H1YXM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

937775:METLIM RS04785
gene id: 937775:METLIM_RS04785
uniprot id: H1YYH2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

937775:METLIM RS08855
gene id: 937775:METLIM_RS08855
uniprot id: H1YX63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

937775:METLIM RS09560
gene id: 937775:METLIM_RS09560
uniprot id: H1YYM0
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

937775:METLIM RS06145
gene id: 937775:METLIM_RS06145
uniprot id: H1Z155
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

937775:METLIM RS15320
gene id: 937775:METLIM_RS15320
uniprot id: H1Z0H5
names: Similarity
messages: Belongs to the acylphosphatase family.

937775:METLIM RS08680
gene id: 937775:METLIM_RS08680
uniprot id: H1YWM9
names: Similarity
messages: Belongs to the eIF-2-alpha family.

937775:METLIM RS07275
gene id: 937775:METLIM_RS07275
uniprot id: H1Z314
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

937775:METLIM RS06120
gene id: 937775:METLIM_RS06120
uniprot id: H1Z150
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

937775:METLIM RS11490
gene id: 937775:METLIM_RS11490
uniprot id: H1Z219
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

937775:METLIM RS04190
gene id: 937775:METLIM_RS04190
uniprot id: H1YXI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS03970
gene id: 937775:METLIM_RS03970
uniprot id: H1YWZ1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

937775:METLIM RS15015
gene id: 937775:METLIM_RS15015
uniprot id: H1YYX7
names: Subcellular Location Annotation
messages: Cytoplasm

937775:METLIM RS08070
gene id: 937775:METLIM_RS08070
uniprot id: H1Z430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

937775:METLIM RS08550
gene id: 937775:METLIM_RS08550
uniprot id: H1YWK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

937775:METLIM RS03405
gene id: 937775:METLIM_RS03405
uniprot id: H1YW87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

937775:METLIM RS05750
gene id: 937775:METLIM_RS05750
uniprot id: H1Z0J1
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS04355
gene id: 937775:METLIM_RS04355
uniprot id: H1YXL9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

937775:METLIM RS02550
gene id: 937775:METLIM_RS02550
uniprot id: H1Z2B9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS10110
gene id: 937775:METLIM_RS10110
uniprot id: H1YZJ5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS08495
gene id: 937775:METLIM_RS08495
uniprot id: H1YWJ4
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS04885
gene id: 937775:METLIM_RS04885
uniprot id: H1YYI7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS10395
gene id: 937775:METLIM_RS10395
uniprot id: H1Z067
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS06030
gene id: 937775:METLIM_RS06030
uniprot id: H1Z0P3
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS04540
gene id: 937775:METLIM_RS04540
uniprot id: H1YXQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

937775:METLIM RS07910
gene id: 937775:METLIM_RS07910
uniprot id: H1Z3S9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS07100
gene id: 937775:METLIM_RS07100
uniprot id: H1Z2J3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

937775:METLIM RS08355
gene id: 937775:METLIM_RS08355
uniprot id: H1YWG5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

937775:METLIM RS09030
gene id: 937775:METLIM_RS09030
uniprot id: H1YX98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

937775:METLIM RS03410
gene id: 937775:METLIM_RS03410
uniprot id: H1YW88
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

937775:METLIM RS12375
gene id: 937775:METLIM_RS12375
uniprot id: H1Z3C5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS05700
gene id: 937775:METLIM_RS05700
uniprot id: H1Z032
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

937775:METLIM RS04265
gene id: 937775:METLIM_RS04265
uniprot id: H1YXK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

937775:METLIM RS06505
gene id: 937775:METLIM_RS06505
uniprot id: H1Z1T3
names: Subcellular Location Annotation
messages: Nucleus

937775:METLIM RS13740
gene id: 937775:METLIM_RS13740
uniprot id: H1YWR2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

937775:METLIM RS14990
gene id: 937775:METLIM_RS14990
uniprot id: H1YYX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

937775:METLIM RS13045
gene id: 937775:METLIM_RS13045
uniprot id: H1Z4C1
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

937775:METLIM RS00995
gene id: 937775:METLIM_RS00995
uniprot id: H1YZT8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

937775:METLIM RS06125
gene id: 937775:METLIM_RS06125
uniprot id: H1Z151
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

937775:METLIM RS13415
gene id: 937775:METLIM_RS13415
uniprot id: H1Z4J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

937775:METLIM RS08515
gene id: 937775:METLIM_RS08515
uniprot id: H1YWJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

937775:METLIM RS08940
gene id: 937775:METLIM_RS08940
uniprot id: H1YX80
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

937775:METLIM RS03660
gene id: 937775:METLIM_RS03660
uniprot id: H1YWD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

937775:METLIM RS13785
gene id: 937775:METLIM_RS13785
uniprot id: H1YWS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

937775:METLIM RS07765
gene id: 937775:METLIM_RS07765
uniprot id: H1Z3Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

937775:METLIM RS08380
gene id: 937775:METLIM_RS08380
uniprot id: H1YWH0
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

937775:METLIM RS09365
gene id: 937775:METLIM_RS09365
uniprot id: H1YXW6
names: Similarity
messages: Belongs to the archease family.

937775:METLIM RS02385
gene id: 937775:METLIM_RS02385
uniprot id: H1Z292
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS10690
gene id: 937775:METLIM_RS10690
uniprot id: H1Z0S0
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS13330
gene id: 937775:METLIM_RS13330
uniprot id: H1Z4H4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

937775:METLIM RS15830
gene id: 937775:METLIM_RS15830
uniprot id: H1YWS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS12535
gene id: 937775:METLIM_RS12535
uniprot id: H1Z3U9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS03430
gene id: 937775:METLIM_RS03430
uniprot id: H1YW92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

937775:METLIM RS12960
gene id: 937775:METLIM_RS12960
uniprot id: H1Z4A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

937775:METLIM RS12630
gene id: 937775:METLIM_RS12630
uniprot id: H1Z3W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

937775:METLIM RS02910
gene id: 937775:METLIM_RS02910
uniprot id: H1Z2Y0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS14315
gene id: 937775:METLIM_RS14315
uniprot id: H1YXH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

937775:METLIM RS04915
gene id: 937775:METLIM_RS04915
uniprot id: H1YYJ3
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

937775:METLIM RS12890
gene id: 937775:METLIM_RS12890
uniprot id: H1Z490
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

937775:METLIM RS06135
gene id: 937775:METLIM_RS06135
uniprot id: H1Z153
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

937775:METLIM RS02615
gene id: 937775:METLIM_RS02615
uniprot id: H1Z2D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

937775:METLIM RS15075
gene id: 937775:METLIM_RS15075
uniprot id: H1YYY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

937775:METLIM RS08700
gene id: 937775:METLIM_RS08700
uniprot id: H1YX33
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

937775:METLIM RS07000
gene id: 937775:METLIM_RS07000
uniprot id: H1Z2H2
names: Similarity
messages: Belongs to the UPF0210 family.

937775:METLIM RS12850
gene id: 937775:METLIM_RS12850
uniprot id: H1Z482
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

937775:METLIM RS08775
gene id: 937775:METLIM_RS08775
uniprot id: H1YX48
names: Function
messages: Part of a potassium transport system.

937775:METLIM RS01145
gene id: 937775:METLIM_RS01145
uniprot id: H1Z0B4
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

937775:METLIM RS13865
gene id: 937775:METLIM_RS13865
uniprot id: H1YWT2
names: Similarity
messages: Belongs to the HisA/HisF family.

937775:METLIM RS13755
gene id: 937775:METLIM_RS13755
uniprot id: H1YWR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

937775:METLIM RS05325
gene id: 937775:METLIM_RS05325
uniprot id: H1YZE1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

937775:METLIM RS06130
gene id: 937775:METLIM_RS06130
uniprot id: H1Z152
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

937775:METLIM RS06720
gene id: 937775:METLIM_RS06720
uniprot id: H1Z1X6
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

937775:METLIM RS03340
gene id: 937775:METLIM_RS03340
uniprot id: H1Z3K1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

937775:METLIM RS13920
gene id: 937775:METLIM_RS13920
uniprot id: H1YWU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

937775:METLIM RS03740
gene id: 937775:METLIM_RS03740
uniprot id: H1YWE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

937775:METLIM RS13480
gene id: 937775:METLIM_RS13480
uniprot id: H1Z4K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

937775:METLIM RS06450
gene id: 937775:METLIM_RS06450
uniprot id: H1Z1S2
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS00045
gene id: 937775:METLIM_RS00045
uniprot id: H1YY65
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

937775:METLIM RS15110
gene id: 937775:METLIM_RS15110
uniprot id: H1YYZ5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

937775:METLIM RS08850
gene id: 937775:METLIM_RS08850
uniprot id: H1YX62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

937775:METLIM RS00520
gene id: 937775:METLIM_RS00520
uniprot id: H1YZ26
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS02575
gene id: 937775:METLIM_RS02575
uniprot id: H1Z2C4
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

937775:METLIM RS02335
gene id: 937775:METLIM_RS02335
uniprot id: H1Z282
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS08780
gene id: 937775:METLIM_RS08780
uniprot id: H1YX49
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

937775:METLIM RS00705
gene id: 937775:METLIM_RS00705
uniprot id: H1YZ61
names: Similarity
messages: Belongs to the GARS family.

937775:METLIM RS06805
gene id: 937775:METLIM_RS06805
uniprot id: H1Z1Z3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

937775:METLIM RS08410
gene id: 937775:METLIM_RS08410
uniprot id: H1YWH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

937775:METLIM RS14965
gene id: 937775:METLIM_RS14965
uniprot id: H1YYW7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

937775:METLIM RS02610
gene id: 937775:METLIM_RS02610
uniprot id: H1Z2D0
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS07525
gene id: 937775:METLIM_RS07525
uniprot id: H1Z360
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS03270
gene id: 937775:METLIM_RS03270
uniprot id: H1Z3I7
names: Similarity
messages: Belongs to the UPF0173 family.

937775:METLIM RS15135
gene id: 937775:METLIM_RS15135
uniprot id: H1YZL9
names: Similarity
messages: Belongs to the UPF0758 family.

937775:METLIM RS14610
gene id: 937775:METLIM_RS14610
uniprot id: H1YY35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

937775:METLIM RS08375
gene id: 937775:METLIM_RS08375
uniprot id: H1YWG9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

937775:METLIM RS03675
gene id: 937775:METLIM_RS03675
uniprot id: H1YWD3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

937775:METLIM RS11820
gene id: 937775:METLIM_RS11820
uniprot id: H1Z2M8
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

937775:METLIM RS06870
gene id: 937775:METLIM_RS06870
uniprot id: H1Z2E6
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.

937775:METLIM RS12775
gene id: 937775:METLIM_RS12775
uniprot id: H1Z3Z3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

937775:METLIM RS07710
gene id: 937775:METLIM_RS07710
uniprot id: H1Z3P0
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS09100
gene id: 937775:METLIM_RS09100
uniprot id: H1YXR7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

937775:METLIM RS06915
gene id: 937775:METLIM_RS06915
uniprot id: H1Z2F5
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

937775:METLIM RS14920
gene id: 937775:METLIM_RS14920
uniprot id: H1YYV7
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

937775:METLIM RS00160
gene id: 937775:METLIM_RS00160
uniprot id: H1YY88
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS06630
gene id: 937775:METLIM_RS06630
uniprot id: H1Z1V8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS01600
gene id: 937775:METLIM_RS01600
uniprot id: H1Z0Z6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

937775:METLIM RS03695
gene id: 937775:METLIM_RS03695
uniprot id: H1YWD7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

937775:METLIM RS14800
gene id: 937775:METLIM_RS14800
uniprot id: H1YYT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

937775:METLIM RS08320
gene id: 937775:METLIM_RS08320
uniprot id: H1YWF8
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

937775:METLIM RS03460
gene id: 937775:METLIM_RS03460
uniprot id: H1YW97
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

937775:METLIM RS02500
gene id: 937775:METLIM_RS02500
uniprot id: H1Z2A9
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

937775:METLIM RS08290
gene id: 937775:METLIM_RS08290
uniprot id: H1Z474
names: Similarity
messages: Belongs to the phosphohexose mutase family.

937775:METLIM RS00365
gene id: 937775:METLIM_RS00365
uniprot id: H1YYD0
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

937775:METLIM RS09680
gene id: 937775:METLIM_RS09680
uniprot id: H1YYP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

937775:METLIM RS14755
gene id: 937775:METLIM_RS14755
uniprot id: H1YYS6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

937775:METLIM RS07790
gene id: 937775:METLIM_RS07790
uniprot id: H1Z3Q5
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS14975
gene id: 937775:METLIM_RS14975
uniprot id: H1YYW9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

937775:METLIM RS07285
gene id: 937775:METLIM_RS07285
uniprot id: H1Z316
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

937775:METLIM RS08385
gene id: 937775:METLIM_RS08385
uniprot id: H1YWH1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

937775:METLIM RS05425
gene id: 937775:METLIM_RS05425
uniprot id: H1YZY0
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

937775:METLIM RS08480
gene id: 937775:METLIM_RS08480
uniprot id: H1YWJ1
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS06625
gene id: 937775:METLIM_RS06625
uniprot id: H1Z1V7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

937775:METLIM RS08585
gene id: 937775:METLIM_RS08585
uniprot id: H1YWL0
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

937775:METLIM RS08190
gene id: 937775:METLIM_RS08190
uniprot id: H1Z454
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS12940
gene id: 937775:METLIM_RS12940
uniprot id: H1Z4A0
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

937775:METLIM RS15215
gene id: 937775:METLIM_RS15215
uniprot id: H1YZN5
names: Similarity
messages: Belongs to the RuvC family.

937775:METLIM RS02935
gene id: 937775:METLIM_RS02935
uniprot id: H1Z2Y4
names: Similarity
messages: Belongs to the UPF0111 family.

937775:METLIM RS00745
gene id: 937775:METLIM_RS00745
uniprot id: H1YZ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

937775:METLIM RS09860
gene id: 937775:METLIM_RS09860
uniprot id: H1YZE9
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

937775:METLIM RS12450
gene id: 937775:METLIM_RS12450
uniprot id: H1Z3D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

937775:METLIM RS14180
gene id: 937775:METLIM_RS14180
uniprot id: H1YXE8
names: Similarity
messages: Belongs to the thioesterase PaaI family.

937775:METLIM RS08310
gene id: 937775:METLIM_RS08310
uniprot id: H1YWF6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

937775:METLIM RS14355
gene id: 937775:METLIM_RS14355
uniprot id: H1YXI3
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

937775:METLIM RS13655
gene id: 937775:METLIM_RS13655
uniprot id: H1YWP5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

937775:METLIM RS03745
gene id: 937775:METLIM_RS03745
uniprot id: H1YWE7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

937775:METLIM RS09345
gene id: 937775:METLIM_RS09345
uniprot id: H1YXW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

937775:METLIM RS13695
gene id: 937775:METLIM_RS13695
uniprot id: H1YWQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

937775:METLIM RS05035
gene id: 937775:METLIM_RS05035
uniprot id: H1YZ88
names: Similarity
messages: Belongs to the DMRL synthase family.

937775:METLIM RS13835
gene id: 937775:METLIM_RS13835
uniprot id: H1YWS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

937775:METLIM RS14155
gene id: 937775:METLIM_RS14155
uniprot id: H1YXE3
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS08675
gene id: 937775:METLIM_RS08675
uniprot id: H1YWM8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

937775:METLIM RS06675
gene id: 937775:METLIM_RS06675
uniprot id: H1Z1W7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

937775:METLIM RS06540
gene id: 937775:METLIM_RS06540
uniprot id: H1Z1U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

937775:METLIM RS12980
gene id: 937775:METLIM_RS12980
uniprot id: H1Z4A8
names: Similarity
messages: Belongs to the AAA ATPase family.

937775:METLIM RS07110
gene id: 937775:METLIM_RS07110
uniprot id: H1Z2J5
names: Similarity
messages: Belongs to the MtrH family.

937775:METLIM RS02265
gene id: 937775:METLIM_RS02265
uniprot id: H1Z269
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

937775:METLIM RS05070
gene id: 937775:METLIM_RS05070
uniprot id: H1YZ94
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS03315
gene id: 937775:METLIM_RS03315
uniprot id: H1Z3J6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

937775:METLIM RS08395
gene id: 937775:METLIM_RS08395
uniprot id: H1YWH4
names: Similarity
messages: Belongs to the PDCD5 family.

937775:METLIM RS06995
gene id: 937775:METLIM_RS06995
uniprot id: H1Z2H1
names: Similarity
messages: Belongs to the UPF0237 family.

937775:METLIM RS00240
gene id: 937775:METLIM_RS00240
uniprot id: H1YYA4
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS04615
gene id: 937775:METLIM_RS04615
uniprot id: H1YYE0
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS07885
gene id: 937775:METLIM_RS07885
uniprot id: H1Z3S4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

937775:METLIM RS05600
gene id: 937775:METLIM_RS05600
uniprot id: H1Z011
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS00640
gene id: 937775:METLIM_RS00640
uniprot id: H1YZ48
names: Similarity
messages: Belongs to the HupF/HypC family.

937775:METLIM RS12680
gene id: 937775:METLIM_RS12680
uniprot id: H1Z3X6
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS12920
gene id: 937775:METLIM_RS12920
uniprot id: H1Z496
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

937775:METLIM RS06220
gene id: 937775:METLIM_RS06220
uniprot id: H1Z170
names: Similarity
messages: Belongs to the UPRTase family.

937775:METLIM RS08400
gene id: 937775:METLIM_RS08400
uniprot id: H1YWH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS08075
gene id: 937775:METLIM_RS08075
uniprot id: H1Z431
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS11610
gene id: 937775:METLIM_RS11610
uniprot id: H1Z243
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

937775:METLIM RS11670
gene id: 937775:METLIM_RS11670
uniprot id: H1Z254
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS03235
gene id: 937775:METLIM_RS03235
uniprot id: H1Z3I0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

937775:METLIM RS07405
gene id: 937775:METLIM_RS07405
uniprot id: H1Z337
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

937775:METLIM RS08150
gene id: 937775:METLIM_RS08150
uniprot id: H1Z446
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS15635
gene id: 937775:METLIM_RS15635
uniprot id: H1YYQ3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS12785
gene id: 937775:METLIM_RS12785
uniprot id: H1Z3Z5
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS08975
gene id: 937775:METLIM_RS08975
uniprot id: H1YX86
names: Similarity
messages: Belongs to the AAA ATPase family.

937775:METLIM RS03670
gene id: 937775:METLIM_RS03670
uniprot id: H1YWD2
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

937775:METLIM RS05335
gene id: 937775:METLIM_RS05335
uniprot id: H1YZE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

937775:METLIM RS05300
gene id: 937775:METLIM_RS05300
uniprot id: H1YZD6
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

937775:METLIM RS14130
gene id: 937775:METLIM_RS14130
uniprot id: H1YXD8
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

937775:METLIM RS08525
gene id: 937775:METLIM_RS08525
uniprot id: H1YWK0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS03470
gene id: 937775:METLIM_RS03470
uniprot id: H1YW99
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

937775:METLIM RS02645
gene id: 937775:METLIM_RS02645
uniprot id: H1Z2D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

937775:METLIM RS13410
gene id: 937775:METLIM_RS13410
uniprot id: H1Z4J1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

937775:METLIM RS08790
gene id: 937775:METLIM_RS08790
uniprot id: H1YX52
names: Similarity
messages: Belongs to the band 7/mec-2 family.

937775:METLIM RS06530
gene id: 937775:METLIM_RS06530
uniprot id: H1Z1T9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

937775:METLIM RS14585
gene id: 937775:METLIM_RS14585
uniprot id: H1YY30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

937775:METLIM RS14345
gene id: 937775:METLIM_RS14345
uniprot id: H1YXI1
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

937775:METLIM RS01845
gene id: 937775:METLIM_RS01845
uniprot id: H1Z144
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

937775:METLIM RS00420
gene id: 937775:METLIM_RS00420
uniprot id: H1YZ07
names: Similarity
messages: Belongs to the glutamate synthase family.

937775:METLIM RS12555
gene id: 937775:METLIM_RS12555
uniprot id: H1Z3V3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

937775:METLIM RS08260
gene id: 937775:METLIM_RS08260
uniprot id: H1Z468
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

937775:METLIM RS05905
gene id: 937775:METLIM_RS05905
uniprot id: H1Z0M0
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

937775:METLIM RS00550
gene id: 937775:METLIM_RS00550
uniprot id: H1YZ32
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

937775:METLIM RS14165
gene id: 937775:METLIM_RS14165
uniprot id: H1YXE5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

937775:METLIM RS12725
gene id: 937775:METLIM_RS12725
uniprot id: H1Z3Y5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS07310
gene id: 937775:METLIM_RS07310
uniprot id: H1Z319
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

937775:METLIM RS05845
gene id: 937775:METLIM_RS05845
uniprot id: H1Z0K9
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

937775:METLIM RS02565
gene id: 937775:METLIM_RS02565
uniprot id: H1Z2C2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

937775:METLIM RS08880
gene id: 937775:METLIM_RS08880
uniprot id: H1YX68
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS11635
gene id: 937775:METLIM_RS11635
uniprot id: H1Z248
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS13015
gene id: 937775:METLIM_RS13015
uniprot id: H1Z4B5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

937775:METLIM RS14245
gene id: 937775:METLIM_RS14245
uniprot id: H1YXG2
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

937775:METLIM RS09685
gene id: 937775:METLIM_RS09685
uniprot id: H1YYP4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

937775:METLIM RS07865
gene id: 937775:METLIM_RS07865
uniprot id: H1Z3S0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

937775:METLIM RS00220
gene id: 937775:METLIM_RS00220
uniprot id: H1YYA0
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

937775:METLIM RS00675
gene id: 937775:METLIM_RS00675
uniprot id: H1YZ55
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS14795
gene id: 937775:METLIM_RS14795
uniprot id: H1YYT3
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS09170
gene id: 937775:METLIM_RS09170
uniprot id: H1YXS8
names: Similarity
messages: Belongs to the peptidase S13 family.

937775:METLIM RS03790
gene id: 937775:METLIM_RS03790
uniprot id: H1YWV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS07315
gene id: 937775:METLIM_RS07315
uniprot id: H1Z321
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

937775:METLIM RS07965
gene id: 937775:METLIM_RS07965
uniprot id: H1Z410
names: Similarity
messages: Belongs to the Ahb/Nir family.

937775:METLIM RS09320
gene id: 937775:METLIM_RS09320
uniprot id: H1YXV7
names: Similarity
messages: Belongs to the UPF0215 family.

937775:METLIM RS14340
gene id: 937775:METLIM_RS14340
uniprot id: H1YXI0
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

937775:METLIM RS15060
gene id: 937775:METLIM_RS15060
uniprot id: H1YYY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

937775:METLIM RS03425
gene id: 937775:METLIM_RS03425
uniprot id: H1YW91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

937775:METLIM RS13425
gene id: 937775:METLIM_RS13425
uniprot id: H1Z4J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

937775:METLIM RS03435
gene id: 937775:METLIM_RS03435
uniprot id: H1YW93
names: Similarity
messages: Belongs to the MEMO1 family.

937775:METLIM RS03320
gene id: 937775:METLIM_RS03320
uniprot id: H1Z3J7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

937775:METLIM RS13745
gene id: 937775:METLIM_RS13745
uniprot id: H1YWR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

937775:METLIM RS07780
gene id: 937775:METLIM_RS07780
uniprot id: H1Z3Q3
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS08330
gene id: 937775:METLIM_RS08330
uniprot id: H1YWG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

937775:METLIM RS14035
gene id: 937775:METLIM_RS14035
uniprot id: H1YXB9
names: Subcellular Location Annotation
messages: Cytoplasm

937775:METLIM RS08875
gene id: 937775:METLIM_RS08875
uniprot id: H1YX67
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS13685
gene id: 937775:METLIM_RS13685
uniprot id: H1YWQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS12770
gene id: 937775:METLIM_RS12770
uniprot id: H1Z3Z2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

937775:METLIM RS08715
gene id: 937775:METLIM_RS08715
uniprot id: H1YX36
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS04225
gene id: 937775:METLIM_RS04225
uniprot id: H1YXJ3
names: Similarity
messages: Belongs to the UPF0251 family.

937775:METLIM RS09875
gene id: 937775:METLIM_RS09875
uniprot id: H1YZF2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

937775:METLIM RS00050
gene id: 937775:METLIM_RS00050
uniprot id: H1YY66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

937775:METLIM RS10150
gene id: 937775:METLIM_RS10150
uniprot id: H1YZK3
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS08365
gene id: 937775:METLIM_RS08365
uniprot id: H1YWG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

937775:METLIM RS04080
gene id: 937775:METLIM_RS04080
uniprot id: H1YX11
names: Similarity
messages: Belongs to the phosphoribulokinase family.

937775:METLIM RS05085
gene id: 937775:METLIM_RS05085
uniprot id: H1YZ97
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS14665
gene id: 937775:METLIM_RS14665
uniprot id: H1YY46
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

937775:METLIM RS09775
gene id: 937775:METLIM_RS09775
uniprot id: H1YYQ9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

937775:METLIM RS14830
gene id: 937775:METLIM_RS14830
uniprot id: H1YYU0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

937775:METLIM RS03785
gene id: 937775:METLIM_RS03785
uniprot id: H1YWV4
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS05160
gene id: 937775:METLIM_RS05160
uniprot id: H1YZB2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

937775:METLIM RS04135
gene id: 937775:METLIM_RS04135
uniprot id: H1YX22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

937775:METLIM RS15355
gene id: 937775:METLIM_RS15355
uniprot id: H1Z285
names: Similarity
messages: Belongs to the DNase I family.

937775:METLIM RS03895
gene id: 937775:METLIM_RS03895
uniprot id: H1YWX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

937775:METLIM RS03810
gene id: 937775:METLIM_RS03810
uniprot id: H1YWV9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

937775:METLIM RS05415
gene id: 937775:METLIM_RS05415
uniprot id: H1YZX8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS01800
gene id: 937775:METLIM_RS01800
uniprot id: H1Z135
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS13395
gene id: 937775:METLIM_RS13395
uniprot id: H1Z4I8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

937775:METLIM RS13010
gene id: 937775:METLIM_RS13010
uniprot id: H1Z4B4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

937775:METLIM RS14910
gene id: 937775:METLIM_RS14910
uniprot id: H1YYV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

937775:METLIM RS14225
gene id: 937775:METLIM_RS14225
uniprot id: H1YXF7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

937775:METLIM RS00535
gene id: 937775:METLIM_RS00535
uniprot id: H1YZ29
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

937775:METLIM RS13710
gene id: 937775:METLIM_RS13710
uniprot id: H1YWQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

937775:METLIM RS03555
gene id: 937775:METLIM_RS03555
uniprot id: H1YWB4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS09260
gene id: 937775:METLIM_RS09260
uniprot id: H1YXU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

937775:METLIM RS15700
gene id: 937775:METLIM_RS15700
uniprot id: H1Z0R9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS14160
gene id: 937775:METLIM_RS14160
uniprot id: H1YXE4
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

937775:METLIM RS03575
gene id: 937775:METLIM_RS03575
uniprot id: H1YWB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

937775:METLIM RS08020
gene id: 937775:METLIM_RS08020
uniprot id: H1Z420
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS08655
gene id: 937775:METLIM_RS08655
uniprot id: H1YWM4
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

937775:METLIM RS00665
gene id: 937775:METLIM_RS00665
uniprot id: H1YZ53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

937775:METLIM RS12670
gene id: 937775:METLIM_RS12670
uniprot id: H1Z3X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

937775:METLIM RS02515
gene id: 937775:METLIM_RS02515
uniprot id: H1Z2B2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

937775:METLIM RS03300
gene id: 937775:METLIM_RS03300
uniprot id: H1Z3J3
names: Similarity
messages: Belongs to the UPF0047 family.

937775:METLIM RS10730
gene id: 937775:METLIM_RS10730
uniprot id: H1Z0S7
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

937775:METLIM RS02885
gene id: 937775:METLIM_RS02885
uniprot id: H1Z2X5
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

937775:METLIM RS13665
gene id: 937775:METLIM_RS13665
uniprot id: H1YWP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

937775:METLIM RS13515
gene id: 937775:METLIM_RS13515
uniprot id: H1Z4L0
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS14310
gene id: 937775:METLIM_RS14310
uniprot id: H1YXH4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

937775:METLIM RS13350
gene id: 937775:METLIM_RS13350
uniprot id: H1Z4H8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS07345
gene id: 937775:METLIM_RS07345
uniprot id: H1Z327
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

937775:METLIM RS06200
gene id: 937775:METLIM_RS06200
uniprot id: H1Z166
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS05725
gene id: 937775:METLIM_RS05725
uniprot id: H1Z0I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

937775:METLIM RS03645
gene id: 937775:METLIM_RS03645
uniprot id: H1YWC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

937775:METLIM RS03500
gene id: 937775:METLIM_RS03500
uniprot id: H1YWA4
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

937775:METLIM RS13345
gene id: 937775:METLIM_RS13345
uniprot id: H1Z4H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

937775:METLIM RS01875
gene id: 937775:METLIM_RS01875
uniprot id: H1Z1K0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

937775:METLIM RS07005
gene id: 937775:METLIM_RS07005
uniprot id: H1Z2H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

937775:METLIM RS09880
gene id: 937775:METLIM_RS09880
uniprot id: H1YZF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

937775:METLIM RS08620
gene id: 937775:METLIM_RS08620
uniprot id: H1YWL7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

937775:METLIM RS04010
gene id: 937775:METLIM_RS04010
uniprot id: H1YWZ8
names: Similarity
messages: Belongs to the DtxR/MntR family.

937775:METLIM RS13870
gene id: 937775:METLIM_RS13870
uniprot id: H1YWT3
names: Similarity
messages: Belongs to the thymidylate kinase family.

937775:METLIM RS00765
gene id: 937775:METLIM_RS00765
uniprot id: H1Z0A6
names: Function
messages: Involved in the transposition of the insertion sequence IS5.

937775:METLIM RS14995
gene id: 937775:METLIM_RS14995
uniprot id: H1YYX3
names: Similarity
messages: Belongs to the archaeal-type GPI family.

937775:METLIM RS05890
gene id: 937775:METLIM_RS05890
uniprot id: H1Z0L6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS13670
gene id: 937775:METLIM_RS13670
uniprot id: H1YWP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

937775:METLIM RS14810
gene id: 937775:METLIM_RS14810
uniprot id: H1YYT6
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

937775:METLIM RS08840
gene id: 937775:METLIM_RS08840
uniprot id: H1YX60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

937775:METLIM RS13030
gene id: 937775:METLIM_RS13030
uniprot id: H1Z4B8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS14730
gene id: 937775:METLIM_RS14730
uniprot id: H1YY58
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

937775:METLIM RS10155
gene id: 937775:METLIM_RS10155
uniprot id: H1YZK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS05315
gene id: 937775:METLIM_RS05315
uniprot id: H1YZD9
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

937775:METLIM RS14335
gene id: 937775:METLIM_RS14335
uniprot id: H1YXH9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

937775:METLIM RS14860
gene id: 937775:METLIM_RS14860
uniprot id: H1YYU6
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

937775:METLIM RS13675
gene id: 937775:METLIM_RS13675
uniprot id: H1YWP9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

937775:METLIM RS06755
gene id: 937775:METLIM_RS06755
uniprot id: H1Z1Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

937775:METLIM RS12985
gene id: 937775:METLIM_RS12985
uniprot id: H1Z4A9
names: Similarity
messages: Belongs to the UPF0107 family.

937775:METLIM RS12935
gene id: 937775:METLIM_RS12935
uniprot id: H1Z499
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

937775:METLIM RS08755
gene id: 937775:METLIM_RS08755
uniprot id: H1YX44
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

937775:METLIM RS12800
gene id: 937775:METLIM_RS12800
uniprot id: H1Z3Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

937775:METLIM RS14440
gene id: 937775:METLIM_RS14440
uniprot id: H1YY00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

937775:METLIM RS08570
gene id: 937775:METLIM_RS08570
uniprot id: H1YWK7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

937775:METLIM RS13635
gene id: 937775:METLIM_RS13635
uniprot id: H1YWP1
names: Subcellular Location Annotation
messages: Membrane

937775:METLIM RS00525
gene id: 937775:METLIM_RS00525
uniprot id: H1YZ27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

937775:METLIM RS06780
gene id: 937775:METLIM_RS06780
uniprot id: H1Z1Y8
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

937775:METLIM RS11520
gene id: 937775:METLIM_RS11520
uniprot id: H1Z225
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

937775:METLIM RS15405
gene id: 937775:METLIM_RS15405
uniprot id: H1YXI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

937775:METLIM RS14325
gene id: 937775:METLIM_RS14325
uniprot id: H1YXH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

937775:METLIM RS10260
gene id: 937775:METLIM_RS10260
uniprot id: H1Z038
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS04895
gene id: 937775:METLIM_RS04895
uniprot id: H1YYI9
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

937775:METLIM RS11960
gene id: 937775:METLIM_RS11960
uniprot id: H1Z2Q8
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

937775:METLIM RS06110
gene id: 937775:METLIM_RS06110
uniprot id: H1Z148
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

937775:METLIM RS00700
gene id: 937775:METLIM_RS00700
uniprot id: H1YZ60
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

937775:METLIM RS05310
gene id: 937775:METLIM_RS05310
uniprot id: H1YZD8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

937775:METLIM RS08055
gene id: 937775:METLIM_RS08055
uniprot id: H1Z427
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS02720
gene id: 937775:METLIM_RS02720
uniprot id: H1Z2U1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

937775:METLIM RS07875
gene id: 937775:METLIM_RS07875
uniprot id: H1Z3S2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

937775:METLIM RS02375
gene id: 937775:METLIM_RS02375
uniprot id: H1Z290
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

937775:METLIM RS07570
gene id: 937775:METLIM_RS07570
uniprot id: H1Z367
names: Similarity
messages: Belongs to the HypD family.

937775:METLIM RS08160
gene id: 937775:METLIM_RS08160
uniprot id: H1Z448
names: Similarity
messages: Belongs to the LarC family.

937775:METLIM RS10415
gene id: 937775:METLIM_RS10415
uniprot id: H1Z071
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S33 family.
messages: Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus.
messages: Part of the tricorn proteolytic complex.

937775:METLIM RS03830
gene id: 937775:METLIM_RS03830
uniprot id: H1YWW3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

937775:METLIM RS05575
gene id: 937775:METLIM_RS05575
uniprot id: H1Z006
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

937775:METLIM RS02580
gene id: 937775:METLIM_RS02580
uniprot id: H1Z2C5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

937775:METLIM RS08770
gene id: 937775:METLIM_RS08770
uniprot id: H1YX47
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

937775:METLIM RS10390
gene id: 937775:METLIM_RS10390
uniprot id: H1Z066
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

937775:METLIM RS03475
gene id: 937775:METLIM_RS03475
uniprot id: H1YWA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

937775:METLIM RS11720
gene id: 937775:METLIM_RS11720
uniprot id: H1Z266
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

937775:METLIM RS04545
gene id: 937775:METLIM_RS04545
uniprot id: H1YXQ6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

937775:METLIM RS13640
gene id: 937775:METLIM_RS13640
uniprot id: H1YWP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

937775:METLIM RS14660
gene id: 937775:METLIM_RS14660
uniprot id: H1YY45
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

937775:METLIM RS14590
gene id: 937775:METLIM_RS14590
uniprot id: H1YY31
names: Similarity
messages: Belongs to the HdrB family.

937775:METLIM RS02175
gene id: 937775:METLIM_RS02175
uniprot id: H1Z1Q5
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

937775:METLIM RS10005
gene id: 937775:METLIM_RS10005
uniprot id: H1YZH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

937775:METLIM RS05115
gene id: 937775:METLIM_RS05115
uniprot id: H1YZA4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

937775:METLIM RS08660
gene id: 937775:METLIM_RS08660
uniprot id: H1YWM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

937775:METLIM RS09865
gene id: 937775:METLIM_RS09865
uniprot id: H1YZF0
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

937775:METLIM RS04495
gene id: 937775:METLIM_RS04495
uniprot id: H1YXP6
names: Similarity
messages: Belongs to the peptidase M24B family.

937775:METLIM RS06115
gene id: 937775:METLIM_RS06115
uniprot id: H1Z149
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

937775:METLIM RS02130
gene id: 937775:METLIM_RS02130
uniprot id: H1Z1P6
names: Similarity
messages: Belongs to the MCM family.

937775:METLIM RS12095
gene id: 937775:METLIM_RS12095
uniprot id: H1Z369
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

937775:METLIM RS02975
gene id: 937775:METLIM_RS02975
uniprot id: H1Z2Z2
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

937775:METLIM RS08350
gene id: 937775:METLIM_RS08350
uniprot id: H1YWG4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

937775:METLIM RS04025
gene id: 937775:METLIM_RS04025
uniprot id: H1YX01
names: Similarity
messages: Belongs to the UDPGP type 2 family.

937775:METLIM RS00080
gene id: 937775:METLIM_RS00080
uniprot id: H1YY72
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

937775:METLIM RS12100
gene id: 937775:METLIM_RS12100
uniprot id: H1Z370
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.