936155:HFELIS RS01370
gene id: 936155:HFELIS_RS01370
uniprot id: E7A8N8
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

936155:HFELIS RS06520
gene id: 936155:HFELIS_RS06520
uniprot id: E7A9S0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

936155:HFELIS RS05850
gene id: 936155:HFELIS_RS05850
uniprot id: E7A930
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS06580
gene id: 936155:HFELIS_RS06580
uniprot id: E7A9T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

936155:HFELIS RS07230
gene id: 936155:HFELIS_RS07230
uniprot id: E7AAL3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

936155:HFELIS RS05550
gene id: 936155:HFELIS_RS05550
uniprot id: E7ADD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

936155:HFELIS RS04460
gene id: 936155:HFELIS_RS04460
uniprot id: E7AC07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

936155:HFELIS RS07640
gene id: 936155:HFELIS_RS07640
uniprot id: E7AB03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

936155:HFELIS RS05275
gene id: 936155:HFELIS_RS05275
uniprot id: E7AD23
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Homodimer.

936155:HFELIS RS05510
gene id: 936155:HFELIS_RS05510
uniprot id: E7ADD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

936155:HFELIS RS03075
gene id: 936155:HFELIS_RS03075
uniprot id: E7AAI3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

936155:HFELIS RS01845
gene id: 936155:HFELIS_RS01845
uniprot id: E7A988
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

936155:HFELIS RS05780
gene id: 936155:HFELIS_RS05780
uniprot id: E7A8W2
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

936155:HFELIS RS03175
gene id: 936155:HFELIS_RS03175
uniprot id: E7AAQ6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

936155:HFELIS RS02545
gene id: 936155:HFELIS_RS02545
uniprot id: E7A9X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

936155:HFELIS RS07990
gene id: 936155:HFELIS_RS07990
uniprot id: E7ABM7
names: Similarity
messages: Belongs to the group II decarboxylase family.

936155:HFELIS RS05095
gene id: 936155:HFELIS_RS05095
uniprot id: E7ACY5
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

936155:HFELIS RS02085
gene id: 936155:HFELIS_RS02085
uniprot id: E7A9I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

936155:HFELIS RS03770
gene id: 936155:HFELIS_RS03770
uniprot id: E7ABG3
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

936155:HFELIS RS01750
gene id: 936155:HFELIS_RS01750
uniprot id: E7A912
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS04700
gene id: 936155:HFELIS_RS04700
uniprot id: E7ACD7
names: Similarity
messages: Belongs to the citrate synthase family.

936155:HFELIS RS01135
gene id: 936155:HFELIS_RS01135
uniprot id: E7AD64
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

936155:HFELIS RS05080
gene id: 936155:HFELIS_RS05080
uniprot id: E7ACY2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

936155:HFELIS RS06990
gene id: 936155:HFELIS_RS06990
uniprot id: E7AAB0
names: Similarity
messages: Belongs to the YggT family.

936155:HFELIS RS02805
gene id: 936155:HFELIS_RS02805
uniprot id: E7AA83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

936155:HFELIS RS06010
gene id: 936155:HFELIS_RS06010
uniprot id: E7A961
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

936155:HFELIS RS01850
gene id: 936155:HFELIS_RS01850
uniprot id: E7A989
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS03485
gene id: 936155:HFELIS_RS03485
uniprot id: E7AB26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

936155:HFELIS RS01700
gene id: 936155:HFELIS_RS01700
uniprot id: E7A902
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

936155:HFELIS RS02465
gene id: 936155:HFELIS_RS02465
uniprot id: E7A9W3
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

936155:HFELIS RS05405
gene id: 936155:HFELIS_RS05405
uniprot id: E7ADB0
names: Function
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

936155:HFELIS RS07075
gene id: 936155:HFELIS_RS07075
uniprot id: E7AAC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

936155:HFELIS RS01735
gene id: 936155:HFELIS_RS01735
uniprot id: E7A909
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS06900
gene id: 936155:HFELIS_RS06900
uniprot id: E7AA93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

936155:HFELIS RS06560
gene id: 936155:HFELIS_RS06560
uniprot id: E7A9S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

936155:HFELIS RS03000
gene id: 936155:HFELIS_RS03000
uniprot id: E7AAG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

936155:HFELIS RS04125
gene id: 936155:HFELIS_RS04125
uniprot id: E7ABU0
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS05420
gene id: 936155:HFELIS_RS05420
uniprot id: E7ADB3
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

936155:HFELIS RS02060
gene id: 936155:HFELIS_RS02060
uniprot id: E7A9D0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS00870
gene id: 936155:HFELIS_RS00870
uniprot id: E7ACU5
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

936155:HFELIS RS06095
gene id: 936155:HFELIS_RS06095
uniprot id: E7A978
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

936155:HFELIS RS06625
gene id: 936155:HFELIS_RS06625
uniprot id: E7A9Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

936155:HFELIS RS06345
gene id: 936155:HFELIS_RS06345
uniprot id: E7A9H7
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

936155:HFELIS RS05475
gene id: 936155:HFELIS_RS05475
uniprot id: E7ADC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

936155:HFELIS RS05925
gene id: 936155:HFELIS_RS05925
uniprot id: E7A945
names: Similarity
messages: Belongs to the peptidase C40 family.

936155:HFELIS RS05265
gene id: 936155:HFELIS_RS05265
uniprot id: E7AD21
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

936155:HFELIS RS02050
gene id: 936155:HFELIS_RS02050
uniprot id: E7A9C8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

936155:HFELIS RS05665
gene id: 936155:HFELIS_RS05665
uniprot id: E7A8T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

936155:HFELIS RS01695
gene id: 936155:HFELIS_RS01695
uniprot id: E7A901
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

936155:HFELIS RS00635
gene id: 936155:HFELIS_RS00635
uniprot id: E7ACQ1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

936155:HFELIS RS04215
gene id: 936155:HFELIS_RS04215
uniprot id: E7ABV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

936155:HFELIS RS03070
gene id: 936155:HFELIS_RS03070
uniprot id: E7AAI2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

936155:HFELIS RS07890
gene id: 936155:HFELIS_RS07890
uniprot id: E7ABB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

936155:HFELIS RS06675
gene id: 936155:HFELIS_RS06675
uniprot id: E7AA01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

936155:HFELIS RS04300
gene id: 936155:HFELIS_RS04300
uniprot id: E7ABX6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

936155:HFELIS RS04960
gene id: 936155:HFELIS_RS04960
uniprot id: E7ACP5
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

936155:HFELIS RS02430
gene id: 936155:HFELIS_RS02430
uniprot id: E7A9V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS05940
gene id: 936155:HFELIS_RS05940
uniprot id: E7A948
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TatB family.
messages: Cell inner membrane

936155:HFELIS RS06570
gene id: 936155:HFELIS_RS06570
uniprot id: E7A9T0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

936155:HFELIS RS08040
gene id: 936155:HFELIS_RS08040
uniprot id: E7AC26
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS01015
gene id: 936155:HFELIS_RS01015
uniprot id: E7AD40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

936155:HFELIS RS07770
gene id: 936155:HFELIS_RS07770
uniprot id: E7AB89
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

936155:HFELIS RS00645
gene id: 936155:HFELIS_RS00645
uniprot id: E7ACQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

936155:HFELIS RS01225
gene id: 936155:HFELIS_RS01225
uniprot id: E7AD82
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

936155:HFELIS RS07795
gene id: 936155:HFELIS_RS07795
uniprot id: E7AB94
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS09470
gene id: 936155:HFELIS_RS09470
uniprot id: E7AAI8
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS06300
gene id: 936155:HFELIS_RS06300
uniprot id: E7A9G8
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS02535
gene id: 936155:HFELIS_RS02535
uniprot id: E7A9X7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS05330
gene id: 936155:HFELIS_RS05330
uniprot id: E7AD95
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS07395
gene id: 936155:HFELIS_RS07395
uniprot id: E7AAV3
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS04695
gene id: 936155:HFELIS_RS04695
uniprot id: E7ACD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

936155:HFELIS RS01510
gene id: 936155:HFELIS_RS01510
uniprot id: E7A8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

936155:HFELIS RS06590
gene id: 936155:HFELIS_RS06590
uniprot id: E7A9T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

936155:HFELIS RS03560
gene id: 936155:HFELIS_RS03560
uniprot id: E7AB37
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

936155:HFELIS RS00385
gene id: 936155:HFELIS_RS00385
uniprot id: E7ACF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

936155:HFELIS RS06635
gene id: 936155:HFELIS_RS06635
uniprot id: E7A9Z3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

936155:HFELIS RS06750
gene id: 936155:HFELIS_RS06750
uniprot id: E7AA16
names: Similarity
messages: Belongs to the glutamine synthetase family.

936155:HFELIS RS00505
gene id: 936155:HFELIS_RS00505
uniprot id: E7ACH6
names: Subcellular Location Annotation
messages: Mitochondrion

936155:HFELIS RS09500
gene id: 936155:HFELIS_RS09500
uniprot id: E7ABZ2
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

936155:HFELIS RS06235
gene id: 936155:HFELIS_RS06235
uniprot id: E7A9F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

936155:HFELIS RS05675
gene id: 936155:HFELIS_RS05675
uniprot id: E7A8T9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS09295
gene id: 936155:HFELIS_RS09295
uniprot id: E7A9X4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

936155:HFELIS RS04430
gene id: 936155:HFELIS_RS04430
uniprot id: E7AC01
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

936155:HFELIS RS01640
gene id: 936155:HFELIS_RS01640
uniprot id: E7A8Z0
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

936155:HFELIS RS07735
gene id: 936155:HFELIS_RS07735
uniprot id: E7AB75
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

936155:HFELIS RS02540
gene id: 936155:HFELIS_RS02540
uniprot id: E7A9X8
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

936155:HFELIS RS06070
gene id: 936155:HFELIS_RS06070
uniprot id: E7A973
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

936155:HFELIS RS01050
gene id: 936155:HFELIS_RS01050
uniprot id: E7AD47
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS02230
gene id: 936155:HFELIS_RS02230
uniprot id: E7A9L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm

936155:HFELIS RS03890
gene id: 936155:HFELIS_RS03890
uniprot id: E7ABI8
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

936155:HFELIS RS02485
gene id: 936155:HFELIS_RS02485
uniprot id: E7A9W7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS02990
gene id: 936155:HFELIS_RS02990
uniprot id: E7AAG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

936155:HFELIS RS06835
gene id: 936155:HFELIS_RS06835
uniprot id: E7AA34
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

936155:HFELIS RS07690
gene id: 936155:HFELIS_RS07690
uniprot id: E7AB68
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

936155:HFELIS RS06685
gene id: 936155:HFELIS_RS06685
uniprot id: E7AA03
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS03810
gene id: 936155:HFELIS_RS03810
uniprot id: E7ABH1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

936155:HFELIS RS04110
gene id: 936155:HFELIS_RS04110
uniprot id: E7ABT8
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

936155:HFELIS RS05065
gene id: 936155:HFELIS_RS05065
uniprot id: E7ACX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

936155:HFELIS RS01855
gene id: 936155:HFELIS_RS01855
uniprot id: E7A990
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

936155:HFELIS RS03970
gene id: 936155:HFELIS_RS03970
uniprot id: E7ABR1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

936155:HFELIS RS06315
gene id: 936155:HFELIS_RS06315
uniprot id: E7A9H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

936155:HFELIS RS04725
gene id: 936155:HFELIS_RS04725
uniprot id: E7ACE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

936155:HFELIS RS03380
gene id: 936155:HFELIS_RS03380
uniprot id: E7AAU4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

936155:HFELIS RS07555
gene id: 936155:HFELIS_RS07555
uniprot id: E7AAY6
names: Similarity
messages: Belongs to the catalase family.

936155:HFELIS RS07635
gene id: 936155:HFELIS_RS07635
uniprot id: E7AB02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

936155:HFELIS RS04410
gene id: 936155:HFELIS_RS04410
uniprot id: E7ABZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

936155:HFELIS RS06665
gene id: 936155:HFELIS_RS06665
uniprot id: E7A9Z9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

936155:HFELIS RS04155
gene id: 936155:HFELIS_RS04155
uniprot id: E7ABU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

936155:HFELIS RS02470
gene id: 936155:HFELIS_RS02470
uniprot id: E7A9W4
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

936155:HFELIS RS07300
gene id: 936155:HFELIS_RS07300
uniprot id: E7AAM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

936155:HFELIS RS03010
gene id: 936155:HFELIS_RS03010
uniprot id: E7AAH0
names: Subcellular Location Annotation
messages: Cytoplasm

936155:HFELIS RS07295
gene id: 936155:HFELIS_RS07295
uniprot id: E7AAM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase B chain family.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

936155:HFELIS RS05860
gene id: 936155:HFELIS_RS05860
uniprot id: E7A932
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

936155:HFELIS RS07330
gene id: 936155:HFELIS_RS07330
uniprot id: E7AAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

936155:HFELIS RS07335
gene id: 936155:HFELIS_RS07335
uniprot id: E7AAN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

936155:HFELIS RS00725
gene id: 936155:HFELIS_RS00725
uniprot id: E7ACR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

936155:HFELIS RS01435
gene id: 936155:HFELIS_RS01435
uniprot id: E7A8Q2
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

936155:HFELIS RS06400
gene id: 936155:HFELIS_RS06400
uniprot id: E7A9P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

936155:HFELIS RS01685
gene id: 936155:HFELIS_RS01685
uniprot id: E7A8Z9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

936155:HFELIS RS02620
gene id: 936155:HFELIS_RS02620
uniprot id: E7AA45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

936155:HFELIS RS00750
gene id: 936155:HFELIS_RS00750
uniprot id: E7ACS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

936155:HFELIS RS03615
gene id: 936155:HFELIS_RS03615
uniprot id: E7AB51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

936155:HFELIS RS01390
gene id: 936155:HFELIS_RS01390
uniprot id: E7A8P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

936155:HFELIS RS04210
gene id: 936155:HFELIS_RS04210
uniprot id: E7ABV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

936155:HFELIS RS01095
gene id: 936155:HFELIS_RS01095
uniprot id: E7AD56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS01100
gene id: 936155:HFELIS_RS01100
uniprot id: E7AD57
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

936155:HFELIS RS05935
gene id: 936155:HFELIS_RS05935
uniprot id: E7A947
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

936155:HFELIS RS06555
gene id: 936155:HFELIS_RS06555
uniprot id: E7A9S7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

936155:HFELIS RS06940
gene id: 936155:HFELIS_RS06940
uniprot id: E7AAA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

936155:HFELIS RS01540
gene id: 936155:HFELIS_RS01540
uniprot id: E7A8X4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

936155:HFELIS RS06085
gene id: 936155:HFELIS_RS06085
uniprot id: E7A976
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

936155:HFELIS RS02090
gene id: 936155:HFELIS_RS02090
uniprot id: E7A9I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

936155:HFELIS RS02405
gene id: 936155:HFELIS_RS02405
uniprot id: E7A9V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

936155:HFELIS RS03040
gene id: 936155:HFELIS_RS03040
uniprot id: E7AAH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

936155:HFELIS RS01655
gene id: 936155:HFELIS_RS01655
uniprot id: E7A8Z3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

936155:HFELIS RS06690
gene id: 936155:HFELIS_RS06690
uniprot id: E7AA04
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

936155:HFELIS RS03200
gene id: 936155:HFELIS_RS03200
uniprot id: E7AAR1
names: Similarity
messages: Belongs to the GARS family.

936155:HFELIS RS06820
gene id: 936155:HFELIS_RS06820
uniprot id: E7AA31
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS01475
gene id: 936155:HFELIS_RS01475
uniprot id: E7A8Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

936155:HFELIS RS09545
gene id: 936155:HFELIS_RS09545
uniprot id: E7ABE1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

936155:HFELIS RS06610
gene id: 936155:HFELIS_RS06610
uniprot id: E7A9T7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

936155:HFELIS RS06425
gene id: 936155:HFELIS_RS06425
uniprot id: E7A9Q0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

936155:HFELIS RS05245
gene id: 936155:HFELIS_RS05245
uniprot id: E7AD17
names: Similarity
messages: Belongs to the HypE family.

936155:HFELIS RS00790
gene id: 936155:HFELIS_RS00790
uniprot id: E7ACS9
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS04870
gene id: 936155:HFELIS_RS04870
uniprot id: E7ACM7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

936155:HFELIS RS04080
gene id: 936155:HFELIS_RS04080
uniprot id: E7ABT2
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS06780
gene id: 936155:HFELIS_RS06780
uniprot id: E7AA23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

936155:HFELIS RS07570
gene id: 936155:HFELIS_RS07570
uniprot id: E7AAY9
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS06375
gene id: 936155:HFELIS_RS06375
uniprot id: E7A9P0
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

936155:HFELIS RS06620
gene id: 936155:HFELIS_RS06620
uniprot id: E7A9Z0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

936155:HFELIS RS02220
gene id: 936155:HFELIS_RS02220
uniprot id: E7A9L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

936155:HFELIS RS04090
gene id: 936155:HFELIS_RS04090
uniprot id: E7ABT4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

936155:HFELIS RS04735
gene id: 936155:HFELIS_RS04735
uniprot id: E7ACE4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

936155:HFELIS RS04955
gene id: 936155:HFELIS_RS04955
uniprot id: E7ACP4
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

936155:HFELIS RS03105
gene id: 936155:HFELIS_RS03105
uniprot id: E7AAJ0
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

936155:HFELIS RS05930
gene id: 936155:HFELIS_RS05930
uniprot id: E7A946
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

936155:HFELIS RS04355
gene id: 936155:HFELIS_RS04355
uniprot id: E7ABY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

936155:HFELIS RS07085
gene id: 936155:HFELIS_RS07085
uniprot id: E7AAC9
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS05775
gene id: 936155:HFELIS_RS05775
uniprot id: E7A8W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

936155:HFELIS RS06755
gene id: 936155:HFELIS_RS06755
uniprot id: E7AA18
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

936155:HFELIS RS04805
gene id: 936155:HFELIS_RS04805
uniprot id: E7ACL4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

936155:HFELIS RS01860
gene id: 936155:HFELIS_RS01860
uniprot id: E7A991
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

936155:HFELIS RS05795
gene id: 936155:HFELIS_RS05795
uniprot id: E7A8W5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell inner membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

936155:HFELIS RS03585
gene id: 936155:HFELIS_RS03585
uniprot id: E7AB45
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS08365
gene id: 936155:HFELIS_RS08365
uniprot id: E7ABL4
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS05980
gene id: 936155:HFELIS_RS05980
uniprot id: Q08716
names: Caution
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.
messages: The orthologous protein is known as the alpha subunit (UreC) in most other bacteria.

936155:HFELIS RS04060
gene id: 936155:HFELIS_RS04060
uniprot id: E7ABS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

936155:HFELIS RS07105
gene id: 936155:HFELIS_RS07105
uniprot id: E7AAD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

936155:HFELIS RS06490
gene id: 936155:HFELIS_RS06490
uniprot id: E7A9R4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS05995
gene id: 936155:HFELIS_RS05995
uniprot id: E7A958
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreH, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

936155:HFELIS RS01040
gene id: 936155:HFELIS_RS01040
uniprot id: E7AD45
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

936155:HFELIS RS03230
gene id: 936155:HFELIS_RS03230
uniprot id: E7AAR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

936155:HFELIS RS04710
gene id: 936155:HFELIS_RS04710
uniprot id: E7ACD9
names: Similarity
messages: Belongs to the HAM1 NTPase family.

936155:HFELIS RS02420
gene id: 936155:HFELIS_RS02420
uniprot id: E7A9V4
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS02650
gene id: 936155:HFELIS_RS02650
uniprot id: E7AA51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

936155:HFELIS RS01060
gene id: 936155:HFELIS_RS01060
uniprot id: E7AD49
names: Similarity
messages: Belongs to the LacAB/RpiB family.

936155:HFELIS RS01325
gene id: 936155:HFELIS_RS01325
uniprot id: E7A8M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

936155:HFELIS RS03330
gene id: 936155:HFELIS_RS03330
uniprot id: E7AAT5
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

936155:HFELIS RS07385
gene id: 936155:HFELIS_RS07385
uniprot id: E7AAP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

936155:HFELIS RS06470
gene id: 936155:HFELIS_RS06470
uniprot id: E7A9R0
names: Similarity
messages: Belongs to the RutC family.

936155:HFELIS RS01305
gene id: 936155:HFELIS_RS01305
uniprot id: E7A8M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

936155:HFELIS RS06725
gene id: 936155:HFELIS_RS06725
uniprot id: E7AA11
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

936155:HFELIS RS02265
gene id: 936155:HFELIS_RS02265
uniprot id: E7A9M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapB family.
messages: Periplasm

936155:HFELIS RS02370
gene id: 936155:HFELIS_RS02370
uniprot id: E7A9U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

936155:HFELIS RS00775
gene id: 936155:HFELIS_RS00775
uniprot id: E7ACS6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS05990
gene id: 936155:HFELIS_RS05990
uniprot id: E7A957
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

936155:HFELIS RS01315
gene id: 936155:HFELIS_RS01315
uniprot id: E7A8M7
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS05260
gene id: 936155:HFELIS_RS05260
uniprot id: E7AD20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

936155:HFELIS RS03325
gene id: 936155:HFELIS_RS03325
uniprot id: E7AAT4
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

936155:HFELIS RS02975
gene id: 936155:HFELIS_RS02975
uniprot id: E7AAG3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

936155:HFELIS RS04690
gene id: 936155:HFELIS_RS04690
uniprot id: E7ACD5
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

936155:HFELIS RS01965
gene id: 936155:HFELIS_RS01965
uniprot id: E7A9B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

936155:HFELIS RS01360
gene id: 936155:HFELIS_RS01360
uniprot id: E7A8N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

936155:HFELIS RS06870
gene id: 936155:HFELIS_RS06870
uniprot id: E7AA41
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

936155:HFELIS RS05375
gene id: 936155:HFELIS_RS05375
uniprot id: E7ADA4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

936155:HFELIS RS04585
gene id: 936155:HFELIS_RS04585
uniprot id: E7ACB4
names: Similarity
messages: Belongs to the peptidase S51 family.

936155:HFELIS RS02395
gene id: 936155:HFELIS_RS02395
uniprot id: E7A9U9
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS00610
gene id: 936155:HFELIS_RS00610
uniprot id: E7ACJ7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

936155:HFELIS RS01990
gene id: 936155:HFELIS_RS01990
uniprot id: E7A9B6
names: Similarity
messages: Belongs to the aspartokinase family.

936155:HFELIS RS01440
gene id: 936155:HFELIS_RS01440
uniprot id: E7A8Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

936155:HFELIS RS02625
gene id: 936155:HFELIS_RS02625
uniprot id: E7AA46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

936155:HFELIS RS02560
gene id: 936155:HFELIS_RS02560
uniprot id: E7A9Y2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

936155:HFELIS RS01470
gene id: 936155:HFELIS_RS01470
uniprot id: E7A8Q7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

936155:HFELIS RS08260
gene id: 936155:HFELIS_RS08260
uniprot id: E7ABD8
names: Similarity
messages: Belongs to the pirin family.

936155:HFELIS RS06225
gene id: 936155:HFELIS_RS06225
uniprot id: E7A9F4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS05710
gene id: 936155:HFELIS_RS05710
uniprot id: E7A8U6
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

936155:HFELIS RS07115
gene id: 936155:HFELIS_RS07115
uniprot id: E7AAD6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

936155:HFELIS RS04755
gene id: 936155:HFELIS_RS04755
uniprot id: E7ACK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

936155:HFELIS RS00205
gene id: 936155:HFELIS_RS00205
uniprot id: E7AC65
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

936155:HFELIS RS01765
gene id: 936155:HFELIS_RS01765
uniprot id: E7A915
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

936155:HFELIS RS05365
gene id: 936155:HFELIS_RS05365
uniprot id: E7ADA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

936155:HFELIS RS04630
gene id: 936155:HFELIS_RS04630
uniprot id: E7ACC3
names: Similarity
messages: Belongs to the TrbI/VirB10 family.

936155:HFELIS RS04525
gene id: 936155:HFELIS_RS04525
uniprot id: E7ACA3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

936155:HFELIS RS06440
gene id: 936155:HFELIS_RS06440
uniprot id: E7A9Q3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

936155:HFELIS RS04520
gene id: 936155:HFELIS_RS04520
uniprot id: E7ACA2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

936155:HFELIS RS06530
gene id: 936155:HFELIS_RS06530
uniprot id: E7A9S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

936155:HFELIS RS01530
gene id: 936155:HFELIS_RS01530
uniprot id: E7A8X2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

936155:HFELIS RS06525
gene id: 936155:HFELIS_RS06525
uniprot id: E7A9S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

936155:HFELIS RS05985
gene id: 936155:HFELIS_RS05985
uniprot id: E7A956
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AmiS/UreI family.
messages: Membrane

936155:HFELIS RS04185
gene id: 936155:HFELIS_RS04185
uniprot id: E7ABV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

936155:HFELIS RS02110
gene id: 936155:HFELIS_RS02110
uniprot id: E7A9J2
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

936155:HFELIS RS06280
gene id: 936155:HFELIS_RS06280
uniprot id: O32617
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

936155:HFELIS RS02165
gene id: 936155:HFELIS_RS02165
uniprot id: E7A9K3
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

936155:HFELIS RS03320
gene id: 936155:HFELIS_RS03320
uniprot id: E7AAT3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS00380
gene id: 936155:HFELIS_RS00380
uniprot id: E7ACF1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

936155:HFELIS RS02390
gene id: 936155:HFELIS_RS02390
uniprot id: E7A9U8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

936155:HFELIS RS03145
gene id: 936155:HFELIS_RS03145
uniprot id: E7AAQ0
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

936155:HFELIS RS03045
gene id: 936155:HFELIS_RS03045
uniprot id: E7AAH7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

936155:HFELIS RS01420
gene id: 936155:HFELIS_RS01420
uniprot id: E7A8P9
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS06935
gene id: 936155:HFELIS_RS06935
uniprot id: E7AAA0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

936155:HFELIS RS06045
gene id: 936155:HFELIS_RS06045
uniprot id: E7A968
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS01180
gene id: 936155:HFELIS_RS01180
uniprot id: E7AD73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

936155:HFELIS RS02415
gene id: 936155:HFELIS_RS02415
uniprot id: E7A9V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
messages: Cell inner membrane
messages: Intake of glucose and galactose.
messages: Membrane

936155:HFELIS RS04975
gene id: 936155:HFELIS_RS04975
uniprot id: E7ACP8
names: Subunit
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

936155:HFELIS RS03180
gene id: 936155:HFELIS_RS03180
uniprot id: E7AAQ7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

936155:HFELIS RS06485
gene id: 936155:HFELIS_RS06485
uniprot id: E7A9R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS04930
gene id: 936155:HFELIS_RS04930
uniprot id: E7ACN9
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS05645
gene id: 936155:HFELIS_RS05645
uniprot id: E7A8T3
names: Similarity
messages: Belongs to the ribF family.

936155:HFELIS RS01320
gene id: 936155:HFELIS_RS01320
uniprot id: E7A8M8
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

936155:HFELIS RS06840
gene id: 936155:HFELIS_RS06840
uniprot id: E7AA35
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

936155:HFELIS RS06645
gene id: 936155:HFELIS_RS06645
uniprot id: E7A9Z5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

936155:HFELIS RS02450
gene id: 936155:HFELIS_RS02450
uniprot id: E7A9W0
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

936155:HFELIS RS05950
gene id: 936155:HFELIS_RS05950
uniprot id: E7A950
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

936155:HFELIS RS01055
gene id: 936155:HFELIS_RS01055
uniprot id: E7AD48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

936155:HFELIS RS06005
gene id: 936155:HFELIS_RS06005
uniprot id: E7A960
names: Similarity
messages: Belongs to the UreD family.

936155:HFELIS RS06745
gene id: 936155:HFELIS_RS06745
uniprot id: E7AA15
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

936155:HFELIS RS01970
gene id: 936155:HFELIS_RS01970
uniprot id: Q9XB38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence.
messages: Heteromer of FlaA and FlaB. FlaB is located proximal to the hook while the remainder of the filament is composed of the predominant FlaA.
messages: Secreted

936155:HFELIS RS04170
gene id: 936155:HFELIS_RS04170
uniprot id: E7ABV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

936155:HFELIS RS07245
gene id: 936155:HFELIS_RS07245
uniprot id: E7AAL5
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

936155:HFELIS RS06575
gene id: 936155:HFELIS_RS06575
uniprot id: E7A9T1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

936155:HFELIS RS03965
gene id: 936155:HFELIS_RS03965
uniprot id: E7ABR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS02550
gene id: 936155:HFELIS_RS02550
uniprot id: E7A9Y0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS03150
gene id: 936155:HFELIS_RS03150
uniprot id: E7AAQ1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

936155:HFELIS RS02605
gene id: 936155:HFELIS_RS02605
uniprot id: E7A9Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

936155:HFELIS RS02895
gene id: 936155:HFELIS_RS02895
uniprot id: E7AAE7
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS02175
gene id: 936155:HFELIS_RS02175
uniprot id: E7A9K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

936155:HFELIS RS06285
gene id: 936155:HFELIS_RS06285
uniprot id: E7A9G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

936155:HFELIS RS01785
gene id: 936155:HFELIS_RS01785
uniprot id: E7A919
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS05035
gene id: 936155:HFELIS_RS05035
uniprot id: E7ACX3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS09490
gene id: 936155:HFELIS_RS09490
uniprot id: E7ABE9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

936155:HFELIS RS03030
gene id: 936155:HFELIS_RS03030
uniprot id: E7AAH4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

936155:HFELIS RS09525
gene id: 936155:HFELIS_RS09525
uniprot id: E7ABM4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

936155:HFELIS RS04085
gene id: 936155:HFELIS_RS04085
uniprot id: E7ABT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

936155:HFELIS RS03775
gene id: 936155:HFELIS_RS03775
uniprot id: E7ABG4
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS00755
gene id: 936155:HFELIS_RS00755
uniprot id: E7ACS2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

936155:HFELIS RS03725
gene id: 936155:HFELIS_RS03725
uniprot id: E7ABF5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

936155:HFELIS RS02700
gene id: 936155:HFELIS_RS02700
uniprot id: E7AA61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

936155:HFELIS RS01070
gene id: 936155:HFELIS_RS01070
uniprot id: E7AD51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS04820
gene id: 936155:HFELIS_RS04820
uniprot id: E7ACL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

936155:HFELIS RS04980
gene id: 936155:HFELIS_RS04980
uniprot id: E7ACP9
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS03370
gene id: 936155:HFELIS_RS03370
uniprot id: E7AAU2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

936155:HFELIS RS03055
gene id: 936155:HFELIS_RS03055
uniprot id: E7AAH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Dps family.
messages: Cytoplasm

936155:HFELIS RS03100
gene id: 936155:HFELIS_RS03100
uniprot id: E7AAI9
names: Similarity
messages: Belongs to the citrate synthase family.

936155:HFELIS RS05040
gene id: 936155:HFELIS_RS05040
uniprot id: E7ACX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

936155:HFELIS RS07410
gene id: 936155:HFELIS_RS07410
uniprot id: E7AAV6
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

936155:HFELIS RS03960
gene id: 936155:HFELIS_RS03960
uniprot id: E7ABQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

936155:HFELIS RS04635
gene id: 936155:HFELIS_RS04635
uniprot id: E7ACC4
names: Similarity
messages: Belongs to the TrbG/VirB9 family.

936155:HFELIS RS02500
gene id: 936155:HFELIS_RS02500
uniprot id: E7A9X0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

936155:HFELIS RS02915
gene id: 936155:HFELIS_RS02915
uniprot id: E7AAF1
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

936155:HFELIS RS01705
gene id: 936155:HFELIS_RS01705
uniprot id: E7A903
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

936155:HFELIS RS02800
gene id: 936155:HFELIS_RS02800
uniprot id: E7AA82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS03215
gene id: 936155:HFELIS_RS03215
uniprot id: E7AAR4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS03090
gene id: 936155:HFELIS_RS03090
uniprot id: E7AAI6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

936155:HFELIS RS00955
gene id: 936155:HFELIS_RS00955
uniprot id: E7ACW3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

936155:HFELIS RS07715
gene id: 936155:HFELIS_RS07715
uniprot id: E7AB71
names: Similarity
messages: Belongs to the HypD family.

936155:HFELIS RS06275
gene id: 936155:HFELIS_RS06275
uniprot id: E7A9G3
names: Similarity
messages: Belongs to the methyltransferase superfamily. PrmA family.

936155:HFELIS RS03750
gene id: 936155:HFELIS_RS03750
uniprot id: E7ABF9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

936155:HFELIS RS00975
gene id: 936155:HFELIS_RS00975
uniprot id: E7AD32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

936155:HFELIS RS07365
gene id: 936155:HFELIS_RS07365
uniprot id: E7AAN9
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

936155:HFELIS RS05135
gene id: 936155:HFELIS_RS05135
uniprot id: E7ACZ3
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

936155:HFELIS RS05285
gene id: 936155:HFELIS_RS05285
uniprot id: E7AD25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS07315
gene id: 936155:HFELIS_RS07315
uniprot id: E7AAM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

936155:HFELIS RS02140
gene id: 936155:HFELIS_RS02140
uniprot id: E7A9J8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

936155:HFELIS RS03680
gene id: 936155:HFELIS_RS03680
uniprot id: E7AB65
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS01775
gene id: 936155:HFELIS_RS01775
uniprot id: E7A917
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

936155:HFELIS RS04935
gene id: 936155:HFELIS_RS04935
uniprot id: E7ACP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

936155:HFELIS RS00170
gene id: 936155:HFELIS_RS00170
uniprot id: E7AC58
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

936155:HFELIS RS07375
gene id: 936155:HFELIS_RS07375
uniprot id: E7AAP1
names: Similarity
messages: Belongs to the thioredoxin family.

936155:HFELIS RS07725
gene id: 936155:HFELIS_RS07725
uniprot id: E7AB73
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

936155:HFELIS RS05325
gene id: 936155:HFELIS_RS05325
uniprot id: E7AD94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

936155:HFELIS RS04415
gene id: 936155:HFELIS_RS04415
uniprot id: E7ABZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

936155:HFELIS RS01005
gene id: 936155:HFELIS_RS01005
uniprot id: E7AD38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

936155:HFELIS RS06405
gene id: 936155:HFELIS_RS06405
uniprot id: E7A9P6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

936155:HFELIS RS05015
gene id: 936155:HFELIS_RS05015
uniprot id: E7ACW9
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

936155:HFELIS RS00860
gene id: 936155:HFELIS_RS00860
uniprot id: E7ACU3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS03655
gene id: 936155:HFELIS_RS03655
uniprot id: E7AB59
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS06290
gene id: 936155:HFELIS_RS06290
uniprot id: O32619
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Probably involved in copper export.

936155:HFELIS RS01985
gene id: 936155:HFELIS_RS01985
uniprot id: E7A9B5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

936155:HFELIS RS05445
gene id: 936155:HFELIS_RS05445
uniprot id: E7ADB8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS03535
gene id: 936155:HFELIS_RS03535
uniprot id: E7AB36
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

936155:HFELIS RS06640
gene id: 936155:HFELIS_RS06640
uniprot id: E7A9Z4
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

936155:HFELIS RS02730
gene id: 936155:HFELIS_RS02730
uniprot id: E7AA68
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

936155:HFELIS RS06165
gene id: 936155:HFELIS_RS06165
uniprot id: E7A9E0
names: Similarity
messages: Belongs to the nitroreductase family.

936155:HFELIS RS04845
gene id: 936155:HFELIS_RS04845
uniprot id: E7ACM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

936155:HFELIS RS03410
gene id: 936155:HFELIS_RS03410
uniprot id: E7AAV0
names: Caution
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS02280
gene id: 936155:HFELIS_RS02280
uniprot id: E7A9M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence.
messages: Heteromer of FlaA and FlaB. FlaB is located proximal to the hook while the remainder of the filament is composed of the predominant FlaA.
messages: Secreted

936155:HFELIS RS02400
gene id: 936155:HFELIS_RS02400
uniprot id: E7A9V0
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

936155:HFELIS RS05105
gene id: 936155:HFELIS_RS05105
uniprot id: E7ACY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

936155:HFELIS RS04990
gene id: 936155:HFELIS_RS04990
uniprot id: E7ACW4
names: Similarity
messages: Belongs to the threonine synthase family.

936155:HFELIS RS06915
gene id: 936155:HFELIS_RS06915
uniprot id: E7AA96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

936155:HFELIS RS06180
gene id: 936155:HFELIS_RS06180
uniprot id: E7A9E3
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

936155:HFELIS RS01000
gene id: 936155:HFELIS_RS01000
uniprot id: E7AD37
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

936155:HFELIS RS02080
gene id: 936155:HFELIS_RS02080
uniprot id: E7A9I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

936155:HFELIS RS00460
gene id: 936155:HFELIS_RS00460
uniprot id: E7ACG7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

936155:HFELIS RS05840
gene id: 936155:HFELIS_RS05840
uniprot id: E7A928
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

936155:HFELIS RS03665
gene id: 936155:HFELIS_RS03665
uniprot id: E7AB61
names: Similarity
messages: Belongs to the peptidase S49 family.

936155:HFELIS RS06565
gene id: 936155:HFELIS_RS06565
uniprot id: E7A9S9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

936155:HFELIS RS06775
gene id: 936155:HFELIS_RS06775
uniprot id: E7AA22
names: Caution
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.
messages: The orthologous protein is known as the alpha subunit (UreC) in most other bacteria.

936155:HFELIS RS05600
gene id: 936155:HFELIS_RS05600
uniprot id: E7A8S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

936155:HFELIS RS07025
gene id: 936155:HFELIS_RS07025
uniprot id: E7AAB7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS04920
gene id: 936155:HFELIS_RS04920
uniprot id: E7ACN7
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

936155:HFELIS RS02240
gene id: 936155:HFELIS_RS02240
uniprot id: E7A9L9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

936155:HFELIS RS01405
gene id: 936155:HFELIS_RS01405
uniprot id: E7A8P6
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

936155:HFELIS RS04750
gene id: 936155:HFELIS_RS04750
uniprot id: E7ACK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

936155:HFELIS RS04395
gene id: 936155:HFELIS_RS04395
uniprot id: E7ABZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

936155:HFELIS RS04290
gene id: 936155:HFELIS_RS04290
uniprot id: E7ABX4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

936155:HFELIS RS07020
gene id: 936155:HFELIS_RS07020
uniprot id: E7AAB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

936155:HFELIS RS04475
gene id: 936155:HFELIS_RS04475
uniprot id: E7AC10
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

936155:HFELIS RS03640
gene id: 936155:HFELIS_RS03640
uniprot id: E7AB56
names: Function
names: Similarity
messages: Belongs to the catalase family.
messages: Has an organic peroxide-dependent peroxidase activity.

936155:HFELIS RS00730
gene id: 936155:HFELIS_RS00730
uniprot id: E7ACR7
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

936155:HFELIS RS07310
gene id: 936155:HFELIS_RS07310
uniprot id: E7AAM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

936155:HFELIS RS02275
gene id: 936155:HFELIS_RS02275
uniprot id: E7A9M6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

936155:HFELIS RS06825
gene id: 936155:HFELIS_RS06825
uniprot id: E7AA32
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

936155:HFELIS RS01875
gene id: 936155:HFELIS_RS01875
uniprot id: E7A994
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

936155:HFELIS RS07720
gene id: 936155:HFELIS_RS07720
uniprot id: E7AB72
names: Similarity
messages: Belongs to the HupF/HypC family.

936155:HFELIS RS09290
gene id: 936155:HFELIS_RS09290
uniprot id: E7A9X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

936155:HFELIS RS01385
gene id: 936155:HFELIS_RS01385
uniprot id: E7A8P2
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

936155:HFELIS RS02030
gene id: 936155:HFELIS_RS02030
uniprot id: E7A9C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

936155:HFELIS RS04345
gene id: 936155:HFELIS_RS04345
uniprot id: E7ABY5
names: Cofactor
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.

936155:HFELIS RS01340
gene id: 936155:HFELIS_RS01340
uniprot id: E7A8N2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

936155:HFELIS RS05380
gene id: 936155:HFELIS_RS05380
uniprot id: E7ADA5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

936155:HFELIS RS04490
gene id: 936155:HFELIS_RS04490
uniprot id: E7AC95
names: Similarity
messages: Belongs to the CTP synthase family.

936155:HFELIS RS01535
gene id: 936155:HFELIS_RS01535
uniprot id: E7A8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

936155:HFELIS RS07695
gene id: 936155:HFELIS_RS07695
uniprot id: E7AB69
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

936155:HFELIS RS02225
gene id: 936155:HFELIS_RS02225
uniprot id: E7A9L6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

936155:HFELIS RS05670
gene id: 936155:HFELIS_RS05670
uniprot id: E7A8T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

936155:HFELIS RS07220
gene id: 936155:HFELIS_RS07220
uniprot id: E7AAL1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

936155:HFELIS RS01140
gene id: 936155:HFELIS_RS01140
uniprot id: E7AD65
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

936155:HFELIS RS00785
gene id: 936155:HFELIS_RS00785
uniprot id: E7ACS8
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

936155:HFELIS RS01120
gene id: 936155:HFELIS_RS01120
uniprot id: E7AD61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

936155:HFELIS RS03450
gene id: 936155:HFELIS_RS03450
uniprot id: E7AB19
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

936155:HFELIS RS06000
gene id: 936155:HFELIS_RS06000
uniprot id: E7A959
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.

936155:HFELIS RS00515
gene id: 936155:HFELIS_RS00515
uniprot id: E7ACH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

936155:HFELIS RS06860
gene id: 936155:HFELIS_RS06860
uniprot id: E7AA39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

936155:HFELIS RS05755
gene id: 936155:HFELIS_RS05755
uniprot id: E7A8V7
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

936155:HFELIS RS06410
gene id: 936155:HFELIS_RS06410
uniprot id: E7A9P7
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

936155:HFELIS RS02750
gene id: 936155:HFELIS_RS02750
uniprot id: E7AA72
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

936155:HFELIS RS02845
gene id: 936155:HFELIS_RS02845
uniprot id: E7AAE1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

936155:HFELIS RS08570
gene id: 936155:HFELIS_RS08570
uniprot id: E7AB13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

936155:HFELIS RS07015
gene id: 936155:HFELIS_RS07015
uniprot id: E7AAB5
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS05595
gene id: 936155:HFELIS_RS05595
uniprot id: E7A8S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

936155:HFELIS RS06845
gene id: 936155:HFELIS_RS06845
uniprot id: E7AA36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

936155:HFELIS RS05640
gene id: 936155:HFELIS_RS05640
uniprot id: E7A8T2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

936155:HFELIS RS04140
gene id: 936155:HFELIS_RS04140
uniprot id: E7ABU4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

936155:HFELIS RS02645
gene id: 936155:HFELIS_RS02645
uniprot id: E7AA50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

936155:HFELIS RS06205
gene id: 936155:HFELIS_RS06205
uniprot id: E7A9E9
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

936155:HFELIS RS03415
gene id: 936155:HFELIS_RS03415
uniprot id: E7AAV1
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

936155:HFELIS RS03765
gene id: 936155:HFELIS_RS03765
uniprot id: E7ABG2
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

936155:HFELIS RS06545
gene id: 936155:HFELIS_RS06545
uniprot id: E7A9S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

936155:HFELIS RS00760
gene id: 936155:HFELIS_RS00760
uniprot id: E7ACS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

936155:HFELIS RS04965
gene id: 936155:HFELIS_RS04965
uniprot id: E7ACP6
names: Similarity
messages: Belongs to the NAD synthetase family.

936155:HFELIS RS00990
gene id: 936155:HFELIS_RS00990
uniprot id: E7AD35
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS07000
gene id: 936155:HFELIS_RS07000
uniprot id: E7AAB2
names: Similarity
messages: Belongs to the UDPGP type 2 family.

936155:HFELIS RS01505
gene id: 936155:HFELIS_RS01505
uniprot id: E7A8R6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

936155:HFELIS RS02905
gene id: 936155:HFELIS_RS02905
uniprot id: E7AAE9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

936155:HFELIS RS05075
gene id: 936155:HFELIS_RS05075
uniprot id: E7ACY1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS00840
gene id: 936155:HFELIS_RS00840
uniprot id: E7ACT9
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

936155:HFELIS RS04350
gene id: 936155:HFELIS_RS04350
uniprot id: E7ABY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

936155:HFELIS RS07010
gene id: 936155:HFELIS_RS07010
uniprot id: E7AAB4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS05130
gene id: 936155:HFELIS_RS05130
uniprot id: E7ACZ2
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

936155:HFELIS RS05855
gene id: 936155:HFELIS_RS05855
uniprot id: E7A931
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

936155:HFELIS RS00480
gene id: 936155:HFELIS_RS00480
uniprot id: E7ACH1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS06075
gene id: 936155:HFELIS_RS06075
uniprot id: E7A974
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

936155:HFELIS RS04535
gene id: 936155:HFELIS_RS04535
uniprot id: E7ACA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane

936155:HFELIS RS04510
gene id: 936155:HFELIS_RS04510
uniprot id: E7ACA0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS07380
gene id: 936155:HFELIS_RS07380
uniprot id: E7AAP2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

936155:HFELIS RS06730
gene id: 936155:HFELIS_RS06730
uniprot id: E7AA12
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

936155:HFELIS RS03580
gene id: 936155:HFELIS_RS03580
uniprot id: E7AB44
names: Similarity
messages: Belongs to the CFA/CMAS family.

936155:HFELIS RS02440
gene id: 936155:HFELIS_RS02440
uniprot id: E7A9V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

936155:HFELIS RS04910
gene id: 936155:HFELIS_RS04910
uniprot id: E7ACN5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

936155:HFELIS RS09355
gene id: 936155:HFELIS_RS09355
uniprot id: E7ACY4
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS02155
gene id: 936155:HFELIS_RS02155
uniprot id: E7A9K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

936155:HFELIS RS05690
gene id: 936155:HFELIS_RS05690
uniprot id: E7A8U2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

936155:HFELIS RS04025
gene id: 936155:HFELIS_RS04025
uniprot id: E7ABS1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

936155:HFELIS RS01485
gene id: 936155:HFELIS_RS01485
uniprot id: E7A8R0
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

936155:HFELIS RS01975
gene id: 936155:HFELIS_RS01975
uniprot id: E7A9B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

936155:HFELIS RS03165
gene id: 936155:HFELIS_RS03165
uniprot id: E7AAQ4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

936155:HFELIS RS04160
gene id: 936155:HFELIS_RS04160
uniprot id: E7ABU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

936155:HFELIS RS02795
gene id: 936155:HFELIS_RS02795
uniprot id: E7AA81
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS07350
gene id: 936155:HFELIS_RS07350
uniprot id: E7AAN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane

936155:HFELIS RS07285
gene id: 936155:HFELIS_RS07285
uniprot id: E7AAM3
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

936155:HFELIS RS09130
gene id: 936155:HFELIS_RS09130
uniprot id: E7AAL7
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

936155:HFELIS RS01020
gene id: 936155:HFELIS_RS01020
uniprot id: E7AD41
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

936155:HFELIS RS06295
gene id: 936155:HFELIS_RS06295
uniprot id: O32620
names: Function
messages: Part of a cation-transporting system which is associated with copper export out of the H.pylori cells.

936155:HFELIS RS04545
gene id: 936155:HFELIS_RS04545
uniprot id: E7ACA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

936155:HFELIS RS02615
gene id: 936155:HFELIS_RS02615
uniprot id: E7A9Y8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

936155:HFELIS RS06395
gene id: 936155:HFELIS_RS06395
uniprot id: E7A9P4
names: Similarity
messages: Belongs to the peptidase A31 family.

936155:HFELIS RS05335
gene id: 936155:HFELIS_RS05335
uniprot id: E7AD96
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

936155:HFELIS RS06230
gene id: 936155:HFELIS_RS06230
uniprot id: E7A9F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

936155:HFELIS RS02590
gene id: 936155:HFELIS_RS02590
uniprot id: E7A9Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

936155:HFELIS RS03255
gene id: 936155:HFELIS_RS03255
uniprot id: E7AAS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

936155:HFELIS RS04505
gene id: 936155:HFELIS_RS04505
uniprot id: E7AC98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

936155:HFELIS RS04810
gene id: 936155:HFELIS_RS04810
uniprot id: E7ACL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

936155:HFELIS RS07945
gene id: 936155:HFELIS_RS07945
uniprot id: E7ABL8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

936155:HFELIS RS04565
gene id: 936155:HFELIS_RS04565
uniprot id: E7ACB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

936155:HFELIS RS09350
gene id: 936155:HFELIS_RS09350
uniprot id: E7ACY3
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS01110
gene id: 936155:HFELIS_RS01110
uniprot id: E7AD59
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS04200
gene id: 936155:HFELIS_RS04200
uniprot id: E7ABV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

936155:HFELIS RS06150
gene id: 936155:HFELIS_RS06150
uniprot id: E7A9D7
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

936155:HFELIS RS06985
gene id: 936155:HFELIS_RS06985
uniprot id: E7AAA9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

936155:HFELIS RS04720
gene id: 936155:HFELIS_RS04720
uniprot id: E7ACE1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

936155:HFELIS RS02635
gene id: 936155:HFELIS_RS02635
uniprot id: E7AA48
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: In the C-terminal section; belongs to the RNA polymerase beta' chain family.
messages: In the N-terminal section; belongs to the RNA polymerase beta chain family.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

936155:HFELIS RS05650
gene id: 936155:HFELIS_RS05650
uniprot id: E7A8T4
names: Similarity
messages: Belongs to the TlyA family.

936155:HFELIS RS07225
gene id: 936155:HFELIS_RS07225
uniprot id: E7AAL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

936155:HFELIS RS06850
gene id: 936155:HFELIS_RS06850
uniprot id: E7AA37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

936155:HFELIS RS05575
gene id: 936155:HFELIS_RS05575
uniprot id: E7A8R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

936155:HFELIS RS07055
gene id: 936155:HFELIS_RS07055
uniprot id: E7AAC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

936155:HFELIS RS07585
gene id: 936155:HFELIS_RS07585
uniprot id: E7AAZ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Homodimer.

936155:HFELIS RS06495
gene id: 936155:HFELIS_RS06495
uniprot id: E7A9R5
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS07470
gene id: 936155:HFELIS_RS07470
uniprot id: E7AAW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

936155:HFELIS RS01335
gene id: 936155:HFELIS_RS01335
uniprot id: E7A8N1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Membrane

936155:HFELIS RS03260
gene id: 936155:HFELIS_RS03260
uniprot id: E7AAS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

936155:HFELIS RS01840
gene id: 936155:HFELIS_RS01840
uniprot id: E7A987
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

936155:HFELIS RS07510
gene id: 936155:HFELIS_RS07510
uniprot id: E7AAX7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

936155:HFELIS RS05845
gene id: 936155:HFELIS_RS05845
uniprot id: E7A929
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

936155:HFELIS RS02595
gene id: 936155:HFELIS_RS02595
uniprot id: E7A9Y5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

936155:HFELIS RS00640
gene id: 936155:HFELIS_RS00640
uniprot id: E7ACQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

936155:HFELIS RS07370
gene id: 936155:HFELIS_RS07370
uniprot id: E7AAP0
names: Similarity
messages: Belongs to the UPF0102 family.

936155:HFELIS RS02735
gene id: 936155:HFELIS_RS02735
uniprot id: E7AA69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

936155:HFELIS RS03080
gene id: 936155:HFELIS_RS03080
uniprot id: E7AAI4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS02385
gene id: 936155:HFELIS_RS02385
uniprot id: E7A9U7
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

936155:HFELIS RS07150
gene id: 936155:HFELIS_RS07150
uniprot id: E7AAJ7
names: Cofactor
names: Similarity
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.

936155:HFELIS RS00545
gene id: 936155:HFELIS_RS00545
uniprot id: E7ACI4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

936155:HFELIS RS01030
gene id: 936155:HFELIS_RS01030
uniprot id: E7AD43
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS01680
gene id: 936155:HFELIS_RS01680
uniprot id: E7A8Z8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS06540
gene id: 936155:HFELIS_RS06540
uniprot id: E7A9S4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

936155:HFELIS RS00875
gene id: 936155:HFELIS_RS00875
uniprot id: E7ACU6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

936155:HFELIS RS02350
gene id: 936155:HFELIS_RS02350
uniprot id: E7A9U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

936155:HFELIS RS04925
gene id: 936155:HFELIS_RS04925
uniprot id: E7ACN8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

936155:HFELIS RS02065
gene id: 936155:HFELIS_RS02065
uniprot id: E7A9I3
names: Similarity
messages: Belongs to the polysaccharide synthase family.

936155:HFELIS RS04245
gene id: 936155:HFELIS_RS04245
uniprot id: E7ABW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

936155:HFELIS RS07040
gene id: 936155:HFELIS_RS07040
uniprot id: E7AAC0
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

936155:HFELIS RS01585
gene id: 936155:HFELIS_RS01585
uniprot id: E7A8Y3
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

936155:HFELIS RS03275
gene id: 936155:HFELIS_RS03275
uniprot id: E7AAS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

936155:HFELIS RS04715
gene id: 936155:HFELIS_RS04715
uniprot id: E7ACE0
names: Similarity
messages: Belongs to the thioredoxin family.

936155:HFELIS RS05830
gene id: 936155:HFELIS_RS05830
uniprot id: E7A926
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

936155:HFELIS RS06600
gene id: 936155:HFELIS_RS06600
uniprot id: E7A9T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

936155:HFELIS RS09125
gene id: 936155:HFELIS_RS09125
uniprot id: E7AAL6
names: Similarity
messages: Belongs to the UbiD family.

936155:HFELIS RS04360
gene id: 936155:HFELIS_RS04360
uniprot id: E7ABY8
names: Function
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
messages: Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide.

936155:HFELIS RS03755
gene id: 936155:HFELIS_RS03755
uniprot id: E7ABG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

936155:HFELIS RS00810
gene id: 936155:HFELIS_RS00810
uniprot id: E7ACT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

936155:HFELIS RS06865
gene id: 936155:HFELIS_RS06865
uniprot id: E7AA40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

936155:HFELIS RS05565
gene id: 936155:HFELIS_RS05565
uniprot id: E7ADE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

936155:HFELIS RS03365
gene id: 936155:HFELIS_RS03365
uniprot id: E7AAU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

936155:HFELIS RS01935
gene id: 936155:HFELIS_RS01935
uniprot id: E7A9A6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

936155:HFELIS RS03225
gene id: 936155:HFELIS_RS03225
uniprot id: E7AAR6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS04855
gene id: 936155:HFELIS_RS04855
uniprot id: E7ACM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

936155:HFELIS RS04470
gene id: 936155:HFELIS_RS04470
uniprot id: E7AC09
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

936155:HFELIS RS06240
gene id: 936155:HFELIS_RS06240
uniprot id: E7A9F8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

936155:HFELIS RS04180
gene id: 936155:HFELIS_RS04180
uniprot id: E7ABV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

936155:HFELIS RS03220
gene id: 936155:HFELIS_RS03220
uniprot id: E7AAR5
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

936155:HFELIS RS05020
gene id: 936155:HFELIS_RS05020
uniprot id: E7ACX0
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

936155:HFELIS RS01490
gene id: 936155:HFELIS_RS01490
uniprot id: E7A8R2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

936155:HFELIS RS06615
gene id: 936155:HFELIS_RS06615
uniprot id: E7A9Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

936155:HFELIS RS06515
gene id: 936155:HFELIS_RS06515
uniprot id: E7A9R9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

936155:HFELIS RS01945
gene id: 936155:HFELIS_RS01945
uniprot id: E7A9A7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

936155:HFELIS RS00815
gene id: 936155:HFELIS_RS00815
uniprot id: E7ACT4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

936155:HFELIS RS07460
gene id: 936155:HFELIS_RS07460
uniprot id: E7AAW6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

936155:HFELIS RS03170
gene id: 936155:HFELIS_RS03170
uniprot id: E7AAQ5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

936155:HFELIS RS04590
gene id: 936155:HFELIS_RS04590
uniprot id: E7ACB5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

936155:HFELIS RS03470
gene id: 936155:HFELIS_RS03470
uniprot id: E7AB23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

936155:HFELIS RS03335
gene id: 936155:HFELIS_RS03335
uniprot id: E7AAT6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

936155:HFELIS RS04070
gene id: 936155:HFELIS_RS04070
uniprot id: E7ABT0
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS02360
gene id: 936155:HFELIS_RS02360
uniprot id: E7A9U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

936155:HFELIS RS03540
gene id: 936155:HFELIS_RS03540
uniprot id: E7AB37
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

936155:HFELIS RS06220
gene id: 936155:HFELIS_RS06220
uniprot id: E7A9F3
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

936155:HFELIS RS07325
gene id: 936155:HFELIS_RS07325
uniprot id: E7AAN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

936155:HFELIS RS03480
gene id: 936155:HFELIS_RS03480
uniprot id: E7AB25
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

936155:HFELIS RS01550
gene id: 936155:HFELIS_RS01550
uniprot id: E7A8X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

936155:HFELIS RS01960
gene id: 936155:HFELIS_RS01960
uniprot id: E7A9B0
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

936155:HFELIS RS05470
gene id: 936155:HFELIS_RS05470
uniprot id: E7ADC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

936155:HFELIS RS01330
gene id: 936155:HFELIS_RS01330
uniprot id: E7A8N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

936155:HFELIS RS00605
gene id: 936155:HFELIS_RS00605
uniprot id: E7ACJ6
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

936155:HFELIS RS06655
gene id: 936155:HFELIS_RS06655
uniprot id: E7A9Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

936155:HFELIS RS05345
gene id: 936155:HFELIS_RS05345
uniprot id: E7AD98
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

936155:HFELIS RS00095
gene id: 936155:HFELIS_RS00095
uniprot id: E7AC65
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

936155:HFELIS RS05270
gene id: 936155:HFELIS_RS05270
uniprot id: E7AD22
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

936155:HFELIS RS04280
gene id: 936155:HFELIS_RS04280
uniprot id: E7ABX2
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS02505
gene id: 936155:HFELIS_RS02505
uniprot id: E7A9X1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

936155:HFELIS RS05030
gene id: 936155:HFELIS_RS05030
uniprot id: E7ACX2
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS01755
gene id: 936155:HFELIS_RS01755
uniprot id: E7A913
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS07630
gene id: 936155:HFELIS_RS07630
uniprot id: E7AB01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

936155:HFELIS RS07665
gene id: 936155:HFELIS_RS07665
uniprot id: E7AB08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

936155:HFELIS RS06175
gene id: 936155:HFELIS_RS06175
uniprot id: E7A9E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

936155:HFELIS RS05620
gene id: 936155:HFELIS_RS05620
uniprot id: E7A8S8
names: Similarity
messages: Belongs to the MotB family.

936155:HFELIS RS04040
gene id: 936155:HFELIS_RS04040
uniprot id: E7ABS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell inner membrane
messages: Homopentamer. In the absence of Mg(2+), interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro.
messages: Mediates influx of magnesium ions.
messages: Membrane

936155:HFELIS RS04400
gene id: 936155:HFELIS_RS04400
uniprot id: E7ABZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

936155:HFELIS RS07320
gene id: 936155:HFELIS_RS07320
uniprot id: E7AAN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

936155:HFELIS RS06355
gene id: 936155:HFELIS_RS06355
uniprot id: E7A9H9
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

936155:HFELIS RS02970
gene id: 936155:HFELIS_RS02970
uniprot id: E7AAG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

936155:HFELIS RS05435
gene id: 936155:HFELIS_RS05435
uniprot id: E7ADB6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

936155:HFELIS RS02075
gene id: 936155:HFELIS_RS02075
uniprot id: E7A9I5
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

936155:HFELIS RS04320
gene id: 936155:HFELIS_RS04320
uniprot id: E7ABY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

936155:HFELIS RS02195
gene id: 936155:HFELIS_RS02195
uniprot id: E7A9K8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS08105
gene id: 936155:HFELIS_RS08105
uniprot id: E7AC12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

936155:HFELIS RS02435
gene id: 936155:HFELIS_RS02435
uniprot id: E7A9V7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

936155:HFELIS RS06630
gene id: 936155:HFELIS_RS06630
uniprot id: E7A9Z2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

936155:HFELIS RS05410
gene id: 936155:HFELIS_RS05410
uniprot id: E7ADB1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS00440
gene id: 936155:HFELIS_RS00440
uniprot id: E7ACG3
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS02215
gene id: 936155:HFELIS_RS02215
uniprot id: E7A9L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

936155:HFELIS RS02720
gene id: 936155:HFELIS_RS02720
uniprot id: E7AA66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

936155:HFELIS RS05730
gene id: 936155:HFELIS_RS05730
uniprot id: E7A8V0
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

936155:HFELIS RS05825
gene id: 936155:HFELIS_RS05825
uniprot id: E7A925
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS07645
gene id: 936155:HFELIS_RS07645
uniprot id: E7AB04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

936155:HFELIS RS02375
gene id: 936155:HFELIS_RS02375
uniprot id: E7A9U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

936155:HFELIS RS03405
gene id: 936155:HFELIS_RS03405
uniprot id: E7AAU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

936155:HFELIS RS06650
gene id: 936155:HFELIS_RS06650
uniprot id: E7A9Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

936155:HFELIS RS00495
gene id: 936155:HFELIS_RS00495
uniprot id: E7ACH4
names: Similarity
messages: Belongs to the GSP E family.

936155:HFELIS RS06100
gene id: 936155:HFELIS_RS06100
uniprot id: E7A979
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

936155:HFELIS RS07405
gene id: 936155:HFELIS_RS07405
uniprot id: E7AAV5
names: Similarity
messages: Belongs to the PrpD family.

936155:HFELIS RS05055
gene id: 936155:HFELIS_RS05055
uniprot id: E7ACX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS07390
gene id: 936155:HFELIS_RS07390
uniprot id: E7AAP4
names: Similarity
messages: Belongs to the ClpA/ClpB family.

936155:HFELIS RS03185
gene id: 936155:HFELIS_RS03185
uniprot id: E7AAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

936155:HFELIS RS02655
gene id: 936155:HFELIS_RS02655
uniprot id: E7AA52
names: Similarity
messages: Belongs to the TrbE/VirB4 family.

936155:HFELIS RS01620
gene id: 936155:HFELIS_RS01620
uniprot id: E7A8Y6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

936155:HFELIS RS06535
gene id: 936155:HFELIS_RS06535
uniprot id: E7A9S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

936155:HFELIS RS06605
gene id: 936155:HFELIS_RS06605
uniprot id: E7A9T6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal.

936155:HFELIS RS02410
gene id: 936155:HFELIS_RS02410
uniprot id: E7A9V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

936155:HFELIS RS00895
gene id: 936155:HFELIS_RS00895
uniprot id: E7ACV0
names: Function
names: Similarity
messages: Belongs to the TrpC family.
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

936155:HFELIS RS05975
gene id: 936155:HFELIS_RS05975
uniprot id: E7A954
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.
messages: In the C-terminal section; belongs to the urease beta subunit family.
messages: In the N-terminal section; belongs to the urease gamma subunit family.
messages: The orthologous protein is known as the gamma/beta subunit (UreAB) in most other bacteria.

936155:HFELIS RS00900
gene id: 936155:HFELIS_RS00900
uniprot id: E7ACV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

936155:HFELIS RS02455
gene id: 936155:HFELIS_RS02455
uniprot id: E7A9W1
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

936155:HFELIS RS03955
gene id: 936155:HFELIS_RS03955
uniprot id: E7ABQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

936155:HFELIS RS05870
gene id: 936155:HFELIS_RS05870
uniprot id: E7A934
names: Similarity
messages: Belongs to the glycosyltransferase 10 family.

936155:HFELIS RS04035
gene id: 936155:HFELIS_RS04035
uniprot id: E7ABS3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

936155:HFELIS RS04560
gene id: 936155:HFELIS_RS04560
uniprot id: E7ACB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

936155:HFELIS RS01080
gene id: 936155:HFELIS_RS01080
uniprot id: E7AD53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

936155:HFELIS RS01525
gene id: 936155:HFELIS_RS01525
uniprot id: E7A8X1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

936155:HFELIS RS06595
gene id: 936155:HFELIS_RS06595
uniprot id: E7A9T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

936155:HFELIS RS01400
gene id: 936155:HFELIS_RS01400
uniprot id: E7A8P5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS05875
gene id: 936155:HFELIS_RS05875
uniprot id: E7A935
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

936155:HFELIS RS06550
gene id: 936155:HFELIS_RS06550
uniprot id: E7A9S6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

936155:HFELIS RS07465
gene id: 936155:HFELIS_RS07465
uniprot id: E7AAW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

936155:HFELIS RS00410
gene id: 936155:HFELIS_RS00410
uniprot id: E7ACF7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

936155:HFELIS RS02775
gene id: 936155:HFELIS_RS02775
uniprot id: E7AA77
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS05955
gene id: 936155:HFELIS_RS05955
uniprot id: E7A951
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

936155:HFELIS RS07435
gene id: 936155:HFELIS_RS07435
uniprot id: E7AAW1
names: Similarity
messages: Belongs to the FBPase class 1 family.

936155:HFELIS RS04780
gene id: 936155:HFELIS_RS04780
uniprot id: E7ACK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

936155:HFELIS RS02965
gene id: 936155:HFELIS_RS02965
uniprot id: E7AAG1
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

936155:HFELIS RS02860
gene id: 936155:HFELIS_RS02860
uniprot id: E7AAE3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

936155:HFELIS RS01625
gene id: 936155:HFELIS_RS01625
uniprot id: E7A8Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

936155:HFELIS RS04095
gene id: 936155:HFELIS_RS04095
uniprot id: E7ABT5
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

936155:HFELIS RS02740
gene id: 936155:HFELIS_RS02740
uniprot id: E7AA70
names: Function
names: Subunit
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence.
messages: Heteromer of FlaA and FlaB. FlaB is located proximal to the hook while the remainder of the filament is composed of the predominant FlaA.

936155:HFELIS RS02630
gene id: 936155:HFELIS_RS02630
uniprot id: E7AA47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

936155:HFELIS RS05305
gene id: 936155:HFELIS_RS05305
uniprot id: E7AD90
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS01835
gene id: 936155:HFELIS_RS01835
uniprot id: E7A986
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

936155:HFELIS RS01515
gene id: 936155:HFELIS_RS01515
uniprot id: E7A8W9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

936155:HFELIS RS03930
gene id: 936155:HFELIS_RS03930
uniprot id: E7ABJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS02660
gene id: 936155:HFELIS_RS02660
uniprot id: E7AA53
names: Subcellular Location Annotation
messages: Membrane

936155:HFELIS RS04315
gene id: 936155:HFELIS_RS04315
uniprot id: E7ABX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

936155:HFELIS RS04175
gene id: 936155:HFELIS_RS04175
uniprot id: E7ABV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

936155:HFELIS RS05415
gene id: 936155:HFELIS_RS05415
uniprot id: E7ADB2
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

936155:HFELIS RS01955
gene id: 936155:HFELIS_RS01955
uniprot id: E7A9A9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

936155:HFELIS RS04205
gene id: 936155:HFELIS_RS04205
uniprot id: E7ABV7
names: Function
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

936155:HFELIS RS07035
gene id: 936155:HFELIS_RS07035
uniprot id: E7AAB9
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

936155:HFELIS RS07030
gene id: 936155:HFELIS_RS07030
uniprot id: E7AAB8
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: The fumarate reductase enzyme complex is required for fumarate respiration. This subunit anchors the complex in the membrane and binds a diheme cytochrome b.

936155:HFELIS RS07610
gene id: 936155:HFELIS_RS07610
uniprot id: E7AAZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

936155:HFELIS RS06455
gene id: 936155:HFELIS_RS06455
uniprot id: E7A9Q7
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

936155:HFELIS RS05745
gene id: 936155:HFELIS_RS05745
uniprot id: E7A8V3
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

936155:HFELIS RS03395
gene id: 936155:HFELIS_RS03395
uniprot id: E7AAU6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

936155:HFELIS RS05390
gene id: 936155:HFELIS_RS05390
uniprot id: E7ADA7
names: Similarity
names: Subunit
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

936155:HFELIS RS06170
gene id: 936155:HFELIS_RS06170
uniprot id: E7A9E1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

936155:HFELIS RS00890
gene id: 936155:HFELIS_RS00890
uniprot id: E7ACU9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

936155:HFELIS RS05945
gene id: 936155:HFELIS_RS05945
uniprot id: E7A949
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

936155:HFELIS RS06015
gene id: 936155:HFELIS_RS06015
uniprot id: E7A962
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

936155:HFELIS RS06460
gene id: 936155:HFELIS_RS06460
uniprot id: E7A9Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane