9361:MAS1
gene id: 9361:MAS1
uniprot id: W8W3I5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9361:IL5
gene id: 9361:IL5
uniprot id: C3PT85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9361:GJB6
gene id: 9361:GJB6
uniprot id: A0A654IFK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9361:SPACA3
gene id: 9361:SPACA3
uniprot id: A0A077SA20
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9361:RBM12
gene id: 9361:RBM12
uniprot id: C3PT65
names: Similarity
messages: Belongs to the copine family.

9361:LOC101446966
gene id: 9361:LOC101446966
uniprot id: A0A654ID65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9361:ATP6AP1
gene id: 9361:ATP6AP1
uniprot id: C3PSZ5
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

9361:GJB2
gene id: 9361:GJB2
uniprot id: A0A654IFJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9361:CRAT
gene id: 9361:CRAT
uniprot id: C1FXV6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9361:PSMD4
gene id: 9361:PSMD4
uniprot id: C1FXU2
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9361:SLC1A5
gene id: 9361:SLC1A5
uniprot id: A0A1B1X4B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9361:DOLPP1
gene id: 9361:DOLPP1
uniprot id: C1FXV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9361:FGF12
gene id: 9361:FGF12
uniprot id: A0A7U3JWI5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9361:ZPR1
gene id: 9361:ZPR1
uniprot id: C3PSW6
names: Similarity
messages: Belongs to the ZPR1 family.

9361:LALBA
gene id: 9361:LALBA
uniprot id: A0A077S2X9
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9361:LEAP2
gene id: 9361:LEAP2
uniprot id: C3PT92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9361:NR2E1
gene id: 9361:NR2E1
uniprot id: C1FXW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9361:GJA1
gene id: 9361:GJA1
uniprot id: A0A654ID12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9361:GRM8
gene id: 9361:GRM8
uniprot id: C0RW24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9361:FGF10
gene id: 9361:FGF10
uniprot id: A0A7U3JWD6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9361:LTB
gene id: 9361:LTB
uniprot id: A0A0U5EMC9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9361:TMEM50B
gene id: 9361:TMEM50B
uniprot id: C3PT20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9361:LOC101412746
gene id: 9361:LOC101412746
uniprot id: C3PT91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9361:CDC42EP5
gene id: 9361:CDC42EP5
uniprot id: C3PTA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9361:WNT2
gene id: 9361:WNT2
uniprot id: Q07E44
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

9361:EIF4ENIF1
gene id: 9361:EIF4ENIF1
uniprot id: C3PSX1
names: Subcellular Location Annotation
messages: Cytoplasm

9361:IFNAR1
gene id: 9361:IFNAR1
uniprot id: C3PT19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9361:CGA
gene id: 9361:CGA
uniprot id: A0A0F7RQ34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted

9361:LOC101430032
gene id: 9361:LOC101430032
uniprot id: A0A7R8C3X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9361:HBE1
gene id: 9361:HBE1
uniprot id: C1FY21
names: Similarity
messages: Belongs to the globin family.

9361:TMOD4
gene id: 9361:TMOD4
uniprot id: C1FXT7
names: Subcellular Location Annotation
messages: cytoskeleton

9361:FGF13
gene id: 9361:FGF13
uniprot id: A0A7U3L4L3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9361:DOLK
gene id: 9361:DOLK
uniprot id: C1FXV2
names: Similarity
messages: Belongs to the polyprenol kinase family.

9361:CXCL8
gene id: 9361:CXCL8
uniprot id: Q102R3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.
messages: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
messages: Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.
messages: Secreted

9361:MTO1
gene id: 9361:MTO1
uniprot id: C3PT40
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

9361:FGF9
gene id: 9361:FGF9
uniprot id: A0A7U3L5M1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9361:IFNB1
gene id: 9361:IFNB1
uniprot id: A0A7R8C3J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9361:HMGN1
gene id: 9361:HMGN1
uniprot id: C1FXS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9361:FGF14
gene id: 9361:FGF14
uniprot id: A0A7U3JWD7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9361:IFGGB1
gene id: 9361:IFGGB1
uniprot id: J7P218
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9361:LOC101446515
gene id: 9361:LOC101446515
uniprot id: A0A654IEL5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9361:MB
gene id: 9361:MB
uniprot id: A0A1K0H3X1
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9361:MGRG1
gene id: 9361:MGRG1
uniprot id: W8W3R6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9361:TNF
gene id: 9361:TNF
uniprot id: Q1WM27
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity).
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9361:ZNF687
gene id: 9361:ZNF687
uniprot id: C1FXU3
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9361:HOXA3
gene id: 9361:HOXA3
uniprot id: C1FXY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9361:C1QB
gene id: 9361:C1QB
uniprot id: A0A3B0J890
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibrillar collagen family.
messages: Trimers of one alpha 2(I) and two alpha 1(I) chains.
messages: Type I collagen is a member of group I collagen (fibrillar forming collagen).
messages: extracellular matrix

9361:GJA8
gene id: 9361:GJA8
uniprot id: A0A654IDM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9361:EEF1A1
gene id: 9361:EEF1A1
uniprot id: C3PT41
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9361:LOC101419758
gene id: 9361:LOC101419758
uniprot id: A0A7R8GV01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9361:LOC101428265
gene id: 9361:LOC101428265
uniprot id: A0A7R8C3L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9361:C1QTNF9
gene id: 9361:C1QTNF9
uniprot id: A0A3B0J014
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibrillar collagen family.
messages: Trimers of one alpha 2(I) and two alpha 1(I) chains.
messages: Type I collagen is a member of group I collagen (fibrillar forming collagen).
messages: extracellular matrix

9361:RPL10
gene id: 9361:RPL10
uniprot id: C3PT02
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9361:IL20
gene id: 9361:IL20
uniprot id: A0A7R8C3N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9361:STEAP1
gene id: 9361:STEAP1
uniprot id: C0RW18
names: Subcellular Location Annotation
messages: Membrane

9361:LOC101436791
gene id: 9361:LOC101436791
uniprot id: C3PT33
names: Similarity
messages: Belongs to the serpin family.

9361:RPS9
gene id: 9361:RPS9
uniprot id: C3PTA5
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9361:VWF
gene id: 9361:VWF
uniprot id: F5XVB2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
messages: Multimeric. Interacts with F8.
messages: Secreted
messages: extracellular matrix

9361:XPR1
gene id: 9361:XPR1
uniprot id: E2J869
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

9361:TNFSF11
gene id: 9361:TNFSF11
uniprot id: A0A0U5J487
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

9361:OLFR67
gene id: 9361:OLFR67
uniprot id: C1FY18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9361:TNFSF8
gene id: 9361:TNFSF8
uniprot id: A0A0U5JAP5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9361:LOC101423638
gene id: 9361:LOC101423638
uniprot id: A0A654IDK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9361:MET
gene id: 9361:MET
uniprot id: Q07E48
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity. Interacts with tensin TNS3 (By similarity). Interacts (when phosphorylated) with tensin TNS4 (via SH2 domain); the interaction increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation (By similarity).
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Membrane
messages: O-mannosylation of IPT/TIG domains by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9361:IL2
gene id: 9361:IL2
uniprot id: Q1WM29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

9361:GDF9
gene id: 9361:GDF9
uniprot id: C3PT90
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9361:GH1
gene id: 9361:GH1
uniprot id: A0A0M6L188
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9361:LOC101438386
gene id: 9361:LOC101438386
uniprot id: C1FY31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9361:TNFSF12
gene id: 9361:TNFSF12
uniprot id: A0A0U5J6Y8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9361:GET1
gene id: 9361:GET1
uniprot id: C1FXS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9361:ENPP1
gene id: 9361:ENPP1
uniprot id: C1FXT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9361:IRF1
gene id: 9361:IRF1
uniprot id: C3PT84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9361:AFG1L
gene id: 9361:AFG1L
uniprot id: C1FXW8
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9361:LOC101439051
gene id: 9361:LOC101439051
uniprot id: C3PT60
names: Similarity
messages: Belongs to the TGF-beta family.

9361:GPHB5
gene id: 9361:GPHB5
uniprot id: A0A0F7RQS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9361:LOC101419859
gene id: 9361:LOC101419859
uniprot id: C3PT13
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

9361:LOC101439017
gene id: 9361:LOC101439017
uniprot id: C1FY23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9361:PTPA
gene id: 9361:PTPA
uniprot id: C1FXV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9361:LOC101435543
gene id: 9361:LOC101435543
uniprot id: A0A1K0GGJ2
names: Similarity
messages: Belongs to the globin family.

9361:GDI1
gene id: 9361:GDI1
uniprot id: C3PSZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9361:LOC101446392
gene id: 9361:LOC101446392
uniprot id: A0A0F7RQK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9361:CD40LG
gene id: 9361:CD40LG
uniprot id: A0A0U5JY63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

9361:LOC101435598
gene id: 9361:LOC101435598
uniprot id: A0A1K0FUM7
names: Similarity
messages: Belongs to the globin family.

9361:LOC101444580
gene id: 9361:LOC101444580
uniprot id: C1FY13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9361:DONSON
gene id: 9361:DONSON
uniprot id: C3PT25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

9361:CDH2
gene id: 9361:CDH2
uniprot id: C1FXT0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9361:TES
gene id: 9361:TES
uniprot id: Q07E51
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

9361:STAG2
gene id: 9361:STAG2
uniprot id: C1FXX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9361:IL10
gene id: 9361:IL10
uniprot id: A0A7R8C3V3
uniprot id: A5JNJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9361:FSCN3
gene id: 9361:FSCN3
uniprot id: C0RW28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9361:TNFSF4
gene id: 9361:TNFSF4
uniprot id: A0A0U5JAL0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9361:OLFR651
gene id: 9361:OLFR651
uniprot id: C1FY34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9361:SNX3
gene id: 9361:SNX3
uniprot id: C1FXW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

9361:GJA5
gene id: 9361:GJA5
uniprot id: A0A654ID17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9361:MFAP1
gene id: 9361:MFAP1
uniprot id: C1FY53
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9361:FGF1
gene id: 9361:FGF1
uniprot id: C1FXS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9361:PSMG1
gene id: 9361:PSMG1
uniprot id: C1FXS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9361:LOC101415721
gene id: 9361:LOC101415721
uniprot id: A0A077S6R0
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9361:LOC131272926
gene id: 9361:LOC131272926
uniprot id: J7P218
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9361:TSHB
gene id: 9361:TSHB
uniprot id: A0A0F7RQI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9361:IL26
gene id: 9361:IL26
uniprot id: A0A7R8C3J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9361:LOC101418868
gene id: 9361:LOC101418868
uniprot id: A0A7R8GVA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9361:GJA4
gene id: 9361:GJA4
uniprot id: A0A654IDM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9361:SSR4
gene id: 9361:SSR4
uniprot id: C3PSY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9361:ADIPOQ
gene id: 9361:ADIPOQ
uniprot id: A0A3B0J2P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibrillar collagen family.
messages: Trimers of one alpha 2(I) and two alpha 1(I) chains.
messages: Type I collagen is a member of group I collagen (fibrillar forming collagen).
messages: extracellular matrix

9361:GJB1
gene id: 9361:GJB1
uniprot id: A0A654ID03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9361:LOC101425111
gene id: 9361:LOC101425111
uniprot id: A0A7R8GV22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9361:CCN2
gene id: 9361:CCN2
uniprot id: C1FXT4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9361:LOC101416168
gene id: 9361:LOC101416168
uniprot id: A0A077S1K8
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9361:COR51P3
gene id: 9361:COR51P3
uniprot id: C1FY11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9361:IFNG
gene id: 9361:IFNG
uniprot id: Q1WM28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Released primarily from activated T lymphocytes.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).

9361:STEAP2
gene id: 9361:STEAP2
uniprot id: C0RW19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9361:INHA
gene id: 9361:INHA
uniprot id: C3PSW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9361:FGF7
gene id: 9361:FGF7
uniprot id: A0A7U3JWE6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9361:PDIA3
gene id: 9361:PDIA3
uniprot id: C1FY49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9361:EXT1
gene id: 9361:EXT1
uniprot id: C1FXV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9361:FGF11
gene id: 9361:FGF11
uniprot id: A0A7U3JWD4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9361:MDFI
gene id: 9361:MDFI
uniprot id: C3PT71
names: Similarity
messages: Belongs to the MDFI family.

9361:TLR6
gene id: 9361:TLR6
uniprot id: Q0ZUL9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cell membrane
messages: Golgi apparatus
messages: Homodimer (via cytoplasmic TIR domain) (By similarity). Heterodimer with TLR2 via their respective extracellular domains. Binds MYD88 via their respective TIR domains (By similarity). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4:TLR6 heterodimerization and signal initiation (By similarity). The heterodimer TLR2:TLR6 interacts with CD14 and CD36 in response to triacylated lipopeptides.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Membrane raft
messages: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
messages: phagosome membrane

9361:ROMO1
gene id: 9361:ROMO1
uniprot id: C3PT68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9361:LOC101422889
gene id: 9361:LOC101422889
uniprot id: C1FY12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9361:NPRL3
gene id: 9361:NPRL3
uniprot id: C1FXX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

9361:LOC101440973
gene id: 9361:LOC101440973
uniprot id: C1FY29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9361:LOC101411895
gene id: 9361:LOC101411895
uniprot id: A0A654IFL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9361:LOC101447555
gene id: 9361:LOC101447555
uniprot id: C3PSX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9361:IFNK
gene id: 9361:IFNK
uniprot id: A0A7R8C3V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9361:MRGPRX2
gene id: 9361:MRGPRX2
uniprot id: W8W3N6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9361:LOC101425560
gene id: 9361:LOC101425560
uniprot id: A0A7R8GV51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9361:SETD3
gene id: 9361:SETD3
uniprot id: C1FXW2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Interacts with MYOD1.
messages: Nucleus
messages: Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation.
messages: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin.
messages: The SET domain specifically recognizes and binds actin, suggesting that it does not accommodate substrates diverging from actin.
messages: Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome.

9361:TNFSF15
gene id: 9361:TNFSF15
uniprot id: A0A0U5J867
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9361:FGF16
gene id: 9361:FGF16
uniprot id: A0A7U3JWG3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9361:LOC101424061
gene id: 9361:LOC101424061
uniprot id: A0A654IEK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9361:PI4KB
gene id: 9361:PI4KB
uniprot id: C1FXU4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9361:LUC7L
gene id: 9361:LUC7L
uniprot id: C1FXX7
names: Similarity
messages: Belongs to the Luc7 family.

9361:DES
gene id: 9361:DES
uniprot id: C3PSV4
names: Similarity
messages: Belongs to the intermediate filament family.

9361:FGF23
gene id: 9361:FGF23
uniprot id: A0A7U3JWE5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9361:LOC101431357
gene id: 9361:LOC101431357
uniprot id: A0A7R8C3X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9361:USP49
gene id: 9361:USP49
uniprot id: C3PT76
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9361:SERPINB10
gene id: 9361:SERPINB10
uniprot id: C3PT36
names: Similarity
messages: Belongs to the serpin family.

9361:GJB7
gene id: 9361:GJB7
uniprot id: A0A654ID50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9361:NFS1
gene id: 9361:NFS1
uniprot id: C3PT67
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9361:LOC101436400
gene id: 9361:LOC101436400
uniprot id: C1FY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9361:APOA1
gene id: 9361:APOA1
uniprot id: C3PSW9
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9361:LOC101438474
gene id: 9361:LOC101438474
uniprot id: A0A7R8C3L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted