9258:SCOC
gene id: 9258:SCOC
uniprot id: A0A6I8NH21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

9258:BOK
gene id: 9258:BOK
uniprot id: F7AGS1
names: Similarity
messages: Belongs to the Bcl-2 family.

9258:VPS53
gene id: 9258:VPS53
uniprot id: F7FTE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9258:ALDH8A1
gene id: 9258:ALDH8A1
uniprot id: A0A6I8NVL9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9258:CCDC25
gene id: 9258:CCDC25
uniprot id: A0A6I8MY06
uniprot id: F6RD85
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9258:CYP1D1
gene id: 9258:CYP1D1
uniprot id: F6T232
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9258:GPD2
gene id: 9258:GPD2
uniprot id: F6WTM1
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

9258:GDPD1
gene id: 9258:GDPD1
uniprot id: F6WP77
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9258:TM4SF1
gene id: 9258:TM4SF1
uniprot id: F7EWP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9258:PFN3
gene id: 9258:PFN3
uniprot id: A0A6I8NLV1
names: Similarity
messages: Belongs to the profilin family.

9258:VCAM1
gene id: 9258:VCAM1
uniprot id: A0A6I8N8A0
names: Subcellular Location Annotation
messages: Cell membrane

9258:NT5C3A
gene id: 9258:NT5C3A
uniprot id: F6Z8C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9258:YBEY
gene id: 9258:YBEY
uniprot id: A0A6I8P2L3
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9258:PIR
gene id: 9258:PIR
uniprot id: F7E913
names: Similarity
messages: Belongs to the pirin family.

9258:LZTFL1
gene id: 9258:LZTFL1
uniprot id: F6WD17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9258:NPVF
gene id: 9258:NPVF
uniprot id: K7E9N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9258:TSPAN14
gene id: 9258:TSPAN14
uniprot id: F7AFP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9258:MON1A
gene id: 9258:MON1A
uniprot id: F7DQX4
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9258:LOC100093154
gene id: 9258:LOC100093154
uniprot id: F6PX78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:SGK1
gene id: 9258:SGK1
uniprot id: F6YI88
uniprot id: K7ED10
names: Similarity
messages: Belongs to the protein kinase superfamily.

9258:UCN3
gene id: 9258:UCN3
uniprot id: A0A6I8N5B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9258:LOC100680802
gene id: 9258:LOC100680802
uniprot id: A0A6I8PDH9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:ACTA2
gene id: 9258:ACTA2
uniprot id: F7F4W9
names: Similarity
messages: Belongs to the actin family.

9258:LOC103165089
gene id: 9258:LOC103165089
uniprot id: F6UME2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

9258:RACK1
gene id: 9258:RACK1
uniprot id: F7E8M7
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

9258:CLRN2
gene id: 9258:CLRN2
uniprot id: A0A6I8NST2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9258:ORNANAV1R3259
gene id: 9258:ORNANAV1R3259
uniprot id: A0A6I8MXZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:XKRX
gene id: 9258:XKRX
uniprot id: A0A6I8P1W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9258:HOXA5
gene id: 9258:HOXA5
uniprot id: F7EJA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9258:LOC103168722
gene id: 9258:LOC103168722
uniprot id: P0C8A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-defensin family.
messages: Has antimicrobial activity.
messages: Highly expressed in spleen, and expressed at lower levels in intestin and lung.
messages: Secreted

9258:HOXB4
gene id: 9258:HOXB4
uniprot id: A0A6I8P2V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9258:C7H6orf89
gene id: 9258:C7H6orf89
uniprot id: F6W2J5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9258:LOC100090615
gene id: 9258:LOC100090615
uniprot id: F7GCV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9258:PPDPFL
gene id: 9258:PPDPFL
uniprot id: F7CKK5
names: Similarity
messages: Belongs to the PPDPF family.

9258:DUSP26
gene id: 9258:DUSP26
uniprot id: F6RVX7
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9258:CD40LG
gene id: 9258:CD40LG
uniprot id: A0A6I8NI35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

9258:JAKMIP2
gene id: 9258:JAKMIP2
uniprot id: F7DIJ8
names: Similarity
messages: Belongs to the JAKMIP family.

9258:IDO2
gene id: 9258:IDO2
uniprot id: B3Y9H7
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9258:TRAPPC2
gene id: 9258:TRAPPC2
uniprot id: F7CLV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9258:CDK2AP1
gene id: 9258:CDK2AP1
uniprot id: A0A6I8P6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9258:LOC100081772
gene id: 9258:LOC100081772
uniprot id: F6QF42
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9258:ORAI3
gene id: 9258:ORAI3
uniprot id: A0A6I8NMG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9258:MDH1
gene id: 9258:MDH1
uniprot id: F7DK14
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9258:GPR68
gene id: 9258:GPR68
uniprot id: F6U2E0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9258:AHCYL2
gene id: 9258:AHCYL2
uniprot id: A0A6I8P214
uniprot id: F7A3U6
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9258:SLCO4A1
gene id: 9258:SLCO4A1
uniprot id: F7DID9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9258:ZWILCH
gene id: 9258:ZWILCH
uniprot id: F7FDV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
messages: kinetochore

9258:ADIPOR1
gene id: 9258:ADIPOR1
uniprot id: F6YTG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9258:PTPA
gene id: 9258:PTPA
uniprot id: F7BSD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9258:LOC100077967
gene id: 9258:LOC100077967
uniprot id: A0A6I8NJR4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9258:TOR3A
gene id: 9258:TOR3A
uniprot id: F7AGI3
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9258:SNRPA1
gene id: 9258:SNRPA1
uniprot id: F6T1N4
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9258:YAE1
gene id: 9258:YAE1
uniprot id: F6ZY55
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9258:LOC100093145
gene id: 9258:LOC100093145
uniprot id: F7A6K4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:ORNANAV1R3129
gene id: 9258:ORNANAV1R3129
uniprot id: F6XAY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:QRSL1
gene id: 9258:QRSL1
uniprot id: F7A3P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9258:LOC100076077
gene id: 9258:LOC100076077
uniprot id: F7F1V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9258:TWF1
gene id: 9258:TWF1
uniprot id: F7EGY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9258:FAM216B
gene id: 9258:FAM216B
uniprot id: K7ECY3
names: Similarity
messages: Belongs to the FAM216 family.

9258:ITM2B
gene id: 9258:ITM2B
uniprot id: F7E819
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9258:GCNT1
gene id: 9258:GCNT1
uniprot id: F6R1I2
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9258:APEX1
gene id: 9258:APEX1
uniprot id: A0A6I8NWR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9258:IGF2
gene id: 9258:IGF2
uniprot id: Q673F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Secreted

9258:SNTG2
gene id: 9258:SNTG2
uniprot id: F6ZT92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9258:KEF28 p06
gene id: 9258:KEF28_p06
uniprot id: Q36456
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion inner membrane

9258:FBLN5
gene id: 9258:FBLN5
uniprot id: F6T7F1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:PATZ1
gene id: 9258:PATZ1
uniprot id: A0A6I8NET0
uniprot id: F7DSP0
names: Subcellular Location Annotation
messages: Nucleus

9258:EIF5A2
gene id: 9258:EIF5A2
uniprot id: A0A6I8MXU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

9258:KIF3C
gene id: 9258:KIF3C
uniprot id: F7EES4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9258:ORNANAV1R3150
gene id: 9258:ORNANAV1R3150
uniprot id: A0A6I8NEK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:SLA
gene id: 9258:SLA
uniprot id: F6UH22
names: Subcellular Location Annotation
messages: Cytoplasm

9258:MPP1
gene id: 9258:MPP1
uniprot id: F7CAB5
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

9258:SUCLA2
gene id: 9258:SUCLA2
uniprot id: A0A6I8N9T9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9258:LOC100083475
gene id: 9258:LOC100083475
uniprot id: F7A481
names: Similarity
messages: Belongs to the intercrine gamma family.

9258:RAB27B
gene id: 9258:RAB27B
uniprot id: A0A6I8P1C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9258:ORNANAV1R3012
gene id: 9258:ORNANAV1R3012
uniprot id: A0A6I8N3D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:PRND
gene id: 9258:PRND
uniprot id: A0A6I8N183
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9258:ORNANAV1R3114
gene id: 9258:ORNANAV1R3114
uniprot id: F6U1N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:DUS4L
gene id: 9258:DUS4L
uniprot id: A0A6I8NTG0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9258:P4HA2
gene id: 9258:P4HA2
uniprot id: A0A6I8NQ75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9258:APOH
gene id: 9258:APOH
uniprot id: F7CUR7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9258:KCNJ2
gene id: 9258:KCNJ2
uniprot id: F7G9G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

9258:ITK
gene id: 9258:ITK
uniprot id: F6PFT9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9258:MGST2
gene id: 9258:MGST2
uniprot id: F6QVY1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:LOC100088430
gene id: 9258:LOC100088430
uniprot id: F7DYH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LOC103165823
gene id: 9258:LOC103165823
uniprot id: F7EFU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9258:RIPPLY3
gene id: 9258:RIPPLY3
uniprot id: A0A6I8N815
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9258:PALMD
gene id: 9258:PALMD
uniprot id: F6YWJ0
names: Similarity
messages: Belongs to the paralemmin family.

9258:NPHS2
gene id: 9258:NPHS2
uniprot id: F6YHB6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9258:MYCN
gene id: 9258:MYCN
uniprot id: A0A6I8NLK7
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9258:MSX1
gene id: 9258:MSX1
uniprot id: A0A6I8NIF4
names: Subcellular Location Annotation
messages: Nucleus

9258:LHFPL5
gene id: 9258:LHFPL5
uniprot id: A0A6I8MX43
names: Subcellular Location Annotation
messages: Membrane

9258:ALLC
gene id: 9258:ALLC
uniprot id: F6VB05
names: Function
names: Similarity
messages: Belongs to the allantoicase family.
messages: The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

9258:NEU2
gene id: 9258:NEU2
uniprot id: F7BZE1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9258:LOC100091819
gene id: 9258:LOC100091819
uniprot id: A0A6I8N9G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:EMC8
gene id: 9258:EMC8
uniprot id: A0A6I8PEL9
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9258:AVPR2
gene id: 9258:AVPR2
uniprot id: F6W1Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Membrane

9258:PTGFR
gene id: 9258:PTGFR
uniprot id: F7DVX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9258:GTF2A1
gene id: 9258:GTF2A1
uniprot id: A0A6I8MX82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9258:FABP2
gene id: 9258:FABP2
uniprot id: F7AEJ8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9258:IPO7
gene id: 9258:IPO7
uniprot id: F6XW40
names: Subcellular Location Annotation
messages: Cytoplasm

9258:TIGD4
gene id: 9258:TIGD4
uniprot id: A0A6I8PIR4
names: Subcellular Location Annotation
messages: Nucleus

9258:C5H1orf158
gene id: 9258:C5H1orf158
uniprot id: A0A6I8N3A4
uniprot id: A0A6I8NNV1
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9258:TIMM8A
gene id: 9258:TIMM8A
uniprot id: F7BKU7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9258:MARVELD1
gene id: 9258:MARVELD1
uniprot id: F7EZU5
names: Subcellular Location Annotation
messages: Membrane

9258:KCNJ16
gene id: 9258:KCNJ16
uniprot id: F7G9G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9258:STT3B
gene id: 9258:STT3B
uniprot id: F7BCX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9258:APOA1
gene id: 9258:APOA1
uniprot id: A0A6I8PHD4
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9258:GOLT1A
gene id: 9258:GOLT1A
uniprot id: F7BYP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9258:TLL1
gene id: 9258:TLL1
uniprot id: F6WCA9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:B3GALT1
gene id: 9258:B3GALT1
uniprot id: F7BPY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9258:OTULINL
gene id: 9258:OTULINL
uniprot id: A0A6I8NDP8
uniprot id: F6YHS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9258:KEF28 p03
gene id: 9258:KEF28_p03
uniprot id: Q36459
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9258:SHMT1
gene id: 9258:SHMT1
uniprot id: K7EA77
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9258:PSMA6
gene id: 9258:PSMA6
uniprot id: F7C9K3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9258:PROK1
gene id: 9258:PROK1
uniprot id: A0A6I8NRX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9258:TTR
gene id: 9258:TTR
uniprot id: F7B925
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9258:ORAN-DRA
gene id: 9258:ORAN-DRA
uniprot id: A7X5M6
names: Similarity
messages: Belongs to the MHC class II family.

9258:NADSYN1
gene id: 9258:NADSYN1
uniprot id: F7DFI1
names: Similarity
names: Subunit
messages: Homohexamer.
messages: In the C-terminal section; belongs to the NAD synthetase family.

9258:LOC100077093
gene id: 9258:LOC100077093
uniprot id: F7EPH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9258:RTN4IP1
gene id: 9258:RTN4IP1
uniprot id: F7A3N2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9258:SLC17A6
gene id: 9258:SLC17A6
uniprot id: F6T3N3
names: Subcellular Location Annotation
messages: Membrane

9258:AKAP4
gene id: 9258:AKAP4
uniprot id: A0A6I8N3M6
names: Similarity
messages: Belongs to the AKAP110 family.

9258:PCK1
gene id: 9258:PCK1
uniprot id: F7EZR3
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

9258:KARS1
gene id: 9258:KARS1
uniprot id: A0A6I8N327
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9258:MC5R
gene id: 9258:MC5R
uniprot id: F6SQY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

9258:LOC100093323
gene id: 9258:LOC100093323
uniprot id: A0A6I8N139
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:MRPS25
gene id: 9258:MRPS25
uniprot id: F7ANY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9258:SGMS2
gene id: 9258:SGMS2
uniprot id: A0A6I8NHQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9258:NXPE3
gene id: 9258:NXPE3
uniprot id: A0A6I8P098
names: Similarity
messages: Belongs to the NXPE family.

9258:TCEA1
gene id: 9258:TCEA1
uniprot id: F7BX76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9258:ORNANAV1R3013
gene id: 9258:ORNANAV1R3013
uniprot id: F6RJC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:RTN1
gene id: 9258:RTN1
uniprot id: A0A6I8N3Z9
uniprot id: A0A6I8PGW7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:BDH1
gene id: 9258:BDH1
uniprot id: A0A6I8MYV8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9258:CLRN1
gene id: 9258:CLRN1
uniprot id: A0A6I8PK10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9258:CENPL
gene id: 9258:CENPL
uniprot id: F6QG26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9258:IFT20
gene id: 9258:IFT20
uniprot id: F7FPP0
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9258:ORNANAV1R3113
gene id: 9258:ORNANAV1R3113
uniprot id: F7BE96
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9258:CD53
gene id: 9258:CD53
uniprot id: F6VK90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9258:SCARB1
gene id: 9258:SCARB1
uniprot id: A0A6I8N6U1
uniprot id: F7F3F3
names: Similarity
messages: Belongs to the CD36 family.

9258:ORNANAV1R3109
gene id: 9258:ORNANAV1R3109
uniprot id: A0A6I8NLG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100093161
gene id: 9258:LOC100093161
uniprot id: A0A6I8PD60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LOC100093250
gene id: 9258:LOC100093250
uniprot id: F6PX78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:TAZ
gene id: 9258:TAZ
uniprot id: F7AYJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9258:GNG10
gene id: 9258:GNG10
uniprot id: A0A6I8NGF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9258:FN3K
gene id: 9258:FN3K
uniprot id: A0A6I8NEV8
names: Similarity
messages: Belongs to the fructosamine kinase family.

9258:ORNANAV1R3189
gene id: 9258:ORNANAV1R3189
uniprot id: A0A6I8NG84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100083398
gene id: 9258:LOC100083398
uniprot id: A0A6I8N5U0
uniprot id: F7FCB8
names: Similarity
messages: Belongs to the peptidase S28 family.

9258:MEF2C
gene id: 9258:MEF2C
uniprot id: A0A6I8NL35
uniprot id: F7FK52
names: Subcellular Location Annotation
messages: Nucleus

9258:SDR42E1
gene id: 9258:SDR42E1
uniprot id: F7GEN9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9258:R3HDML
gene id: 9258:R3HDML
uniprot id: F6UAZ5
names: Similarity
messages: Belongs to the CRISP family.

9258:SLC13A1
gene id: 9258:SLC13A1
uniprot id: A0A6I8NU30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9258:POMGNT2
gene id: 9258:POMGNT2
uniprot id: F6TKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:CHST11
gene id: 9258:CHST11
uniprot id: A0A6I8P6U8
uniprot id: A0A6I8PAN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9258:TRPC3
gene id: 9258:TRPC3
uniprot id: F6XTG1
names: Subcellular Location Annotation
messages: Membrane

9258:TIMM22
gene id: 9258:TIMM22
uniprot id: A0A6I8NBR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9258:ANO3
gene id: 9258:ANO3
uniprot id: F6T3H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9258:FKTN
gene id: 9258:FKTN
uniprot id: A0A6I8PNJ9
names: Similarity
messages: Belongs to the LicD transferase family.

9258:KEF28 p08
gene id: 9258:KEF28_p08
uniprot id: Q36454
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9258:LOC100093337
gene id: 9258:LOC100093337
uniprot id: F7DNX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LOC103168757
gene id: 9258:LOC103168757
uniprot id: F6SDR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9258:ABI1
gene id: 9258:ABI1
uniprot id: A0A6I8NI41
uniprot id: A0A6I8P3V9
uniprot id: F6RH58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9258:USP30
gene id: 9258:USP30
uniprot id: F7G2Z6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9258:LIX1
gene id: 9258:LIX1
uniprot id: A0A6I8PIK6
names: Similarity
messages: Belongs to the LIX1 family.

9258:STX7
gene id: 9258:STX7
uniprot id: F7E0A0
names: Similarity
messages: Belongs to the syntaxin family.

9258:CUEDC2
gene id: 9258:CUEDC2
uniprot id: F6TTC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9258:KXD1
gene id: 9258:KXD1
uniprot id: A0A6I8NNZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9258:CALB2
gene id: 9258:CALB2
uniprot id: F6QAK7
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9258:PEMT
gene id: 9258:PEMT
uniprot id: F7G965
uniprot id: K7EE81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9258:UPP1
gene id: 9258:UPP1
uniprot id: F6YMY1
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9258:LOC100079085
gene id: 9258:LOC100079085
uniprot id: A0A6I8PGD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9258:TMED6
gene id: 9258:TMED6
uniprot id: F6TLX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:RPL24
gene id: 9258:RPL24
uniprot id: F6PPT9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9258:SMAD9
gene id: 9258:SMAD9
uniprot id: F6Y0Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9258:TRAF6
gene id: 9258:TRAF6
uniprot id: F6S636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9258:HOPX
gene id: 9258:HOPX
uniprot id: A0A6I8N5T3
names: Subcellular Location Annotation
messages: Nucleus

9258:VOPP1
gene id: 9258:VOPP1
uniprot id: F6T8H8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Endosome membrane
messages: Interacts with WWOX (via WW domain).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9258:LOC103170948
gene id: 9258:LOC103170948
uniprot id: F7DZT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100078875
gene id: 9258:LOC100078875
uniprot id: F7F710
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9258:ZDHHC13
gene id: 9258:ZDHHC13
uniprot id: F7DFK1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9258:TSHB
gene id: 9258:TSHB
uniprot id: F7FHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9258:RPS13
gene id: 9258:RPS13
uniprot id: F6VCQ3
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9258:GGACT
gene id: 9258:GGACT
uniprot id: F7D438
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9258:BRINP2
gene id: 9258:BRINP2
uniprot id: F7CDU2
names: Similarity
messages: Belongs to the BRINP family.

9258:NTSR1
gene id: 9258:NTSR1
uniprot id: F7DIF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:SEMA3C
gene id: 9258:SEMA3C
uniprot id: A0A6I8NJ34
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9258:LOC100089477
gene id: 9258:LOC100089477
uniprot id: F7CZD2
names: Similarity
messages: Belongs to the serpin family.

9258:BRINP1
gene id: 9258:BRINP1
uniprot id: F6PG64
names: Similarity
messages: Belongs to the BRINP family.

9258:ARL3
gene id: 9258:ARL3
uniprot id: F7D0F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9258:NSMCE2
gene id: 9258:NSMCE2
uniprot id: A0A6I8P9B6
uniprot id: F6WLQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

9258:ATP2C2
gene id: 9258:ATP2C2
uniprot id: F7G926
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9258:UCMA
gene id: 9258:UCMA
uniprot id: F6UFG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

9258:CALHM2
gene id: 9258:CALHM2
uniprot id: A0A6I8P834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9258:HSDL1
gene id: 9258:HSDL1
uniprot id: F6SBK8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9258:LOC100082460
gene id: 9258:LOC100082460
uniprot id: A0A6I8NVX6
uniprot id: A0A6I8P044
uniprot id: F6X178
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

9258:ACSL5
gene id: 9258:ACSL5
uniprot id: F7F8D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9258:LOC100076673
gene id: 9258:LOC100076673
uniprot id: F6VIH9
names: Similarity
messages: Belongs to the actin family.

9258:LOC100681852
gene id: 9258:LOC100681852
uniprot id: F6UMQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LYZ
gene id: 9258:LYZ
uniprot id: F7CJ99
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9258:GJA3
gene id: 9258:GJA3
uniprot id: A0A6I8N3H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9258:RPL36
gene id: 9258:RPL36
uniprot id: F7GCM1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9258:SLC31A1
gene id: 9258:SLC31A1
uniprot id: F7ALW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9258:TMEM184A
gene id: 9258:TMEM184A
uniprot id: F6QPD0
names: Subcellular Location Annotation
messages: Membrane

9258:GINS4
gene id: 9258:GINS4
uniprot id: F6XB21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9258:LOC103165286
gene id: 9258:LOC103165286
uniprot id: F6U6X6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9258:ORNANAV1R3170
gene id: 9258:ORNANAV1R3170
uniprot id: A0A6I8PJQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:STMN1
gene id: 9258:STMN1
uniprot id: F7F009
names: Similarity
messages: Belongs to the stathmin family.

9258:TFAP2A
gene id: 9258:TFAP2A
uniprot id: A0A6I8NVS6
uniprot id: F6XY74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9258:SAMD8
gene id: 9258:SAMD8
uniprot id: F6QNA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9258:LOC100083762
gene id: 9258:LOC100083762
uniprot id: A0A6I8NP18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:NPY2R
gene id: 9258:NPY2R
uniprot id: F7EXP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TMSB4X
gene id: 9258:TMSB4X
uniprot id: A0A6I8NUH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9258:MARK1
gene id: 9258:MARK1
uniprot id: A0A6I8NG83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9258:ODR4
gene id: 9258:ODR4
uniprot id: A0A6I8NHZ0
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9258:CPLX1
gene id: 9258:CPLX1
uniprot id: F7C7B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9258:HOXB9
gene id: 9258:HOXB9
uniprot id: F7BDQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9258:CLDN3
gene id: 9258:CLDN3
uniprot id: F7FSX7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9258:CALB1
gene id: 9258:CALB1
uniprot id: F7E5Y5
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

9258:CCN4
gene id: 9258:CCN4
uniprot id: F6UH66
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9258:PPP2R5E
gene id: 9258:PPP2R5E
uniprot id: F7G755
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9258:MIF
gene id: 9258:MIF
uniprot id: F7DCF9
names: Similarity
messages: Belongs to the MIF family.

9258:ORNANAV1R3194
gene id: 9258:ORNANAV1R3194
uniprot id: A0A6I8N3G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100082203
gene id: 9258:LOC100082203
uniprot id: F7GA85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:ACKR4
gene id: 9258:ACKR4
uniprot id: F6X8W5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9258:PSMB5
gene id: 9258:PSMB5
uniprot id: F7ECF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9258:LOC100079187
gene id: 9258:LOC100079187
uniprot id: F7D5Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9258:WDR83OS
gene id: 9258:WDR83OS
uniprot id: F7AU57
names: Similarity
messages: Belongs to the Asterix family.

9258:CFTR
gene id: 9258:CFTR
uniprot id: Q07DZ6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).
messages: N-glycosylated.
messages: Nucleus
messages: Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.
messages: Recycling endosome membrane
messages: The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, NHERF1/EBP50 complex.
messages: The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.
messages: Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity).

9258:MED18
gene id: 9258:MED18
uniprot id: A0A6I8NAH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9258:RORB
gene id: 9258:RORB
uniprot id: A0A6I8NZX3
uniprot id: F6S706
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9258:MRPL42
gene id: 9258:MRPL42
uniprot id: F6VUI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9258:TP53I11
gene id: 9258:TP53I11
uniprot id: A0A6I8NMH1
names: Subcellular Location Annotation
messages: Membrane

9258:TOR1AIP2
gene id: 9258:TOR1AIP2
uniprot id: A0A6I8PCP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9258:DPH5
gene id: 9258:DPH5
uniprot id: F6Q8D4
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9258:FNIP1
gene id: 9258:FNIP1
uniprot id: F7G6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9258:AKAP5
gene id: 9258:AKAP5
uniprot id: F7B741
names: Subcellular Location Annotation
messages: Membrane

9258:PTER
gene id: 9258:PTER
uniprot id: A0A6I8NMN6
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:LOC100085933
gene id: 9258:LOC100085933
uniprot id: A0A6I8PEY6
names: Subcellular Location Annotation
messages: Membrane

9258:RPL11
gene id: 9258:RPL11
uniprot id: F7EFX6
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9258:MAU2
gene id: 9258:MAU2
uniprot id: F7FZT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9258:PLP1
gene id: 9258:PLP1
uniprot id: A0A6I8N089
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9258:COPG2
gene id: 9258:COPG2
uniprot id: F6YKB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9258:LOC100682153
gene id: 9258:LOC100682153
uniprot id: F6QKB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:PABPC1
gene id: 9258:PABPC1
uniprot id: F6XVK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9258:LOC100073534
gene id: 9258:LOC100073534
uniprot id: F7CIV4
names: Similarity
messages: Belongs to the actin family.

9258:CDK8
gene id: 9258:CDK8
uniprot id: A0A6I8PEA9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9258:PDGFC
gene id: 9258:PDGFC
uniprot id: A0A6I8NXK0
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:ERG
gene id: 9258:ERG
uniprot id: A0A6I8NZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9258:LOC100076913
gene id: 9258:LOC100076913
uniprot id: A0A6I8PF82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:THUMPD3
gene id: 9258:THUMPD3
uniprot id: F6WCE9
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9258:LOC100083109
gene id: 9258:LOC100083109
uniprot id: F7GAE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:SYT1
gene id: 9258:SYT1
uniprot id: A0A6I8PE80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9258:NKAIN4
gene id: 9258:NKAIN4
uniprot id: F7DEW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9258:MRPS10
gene id: 9258:MRPS10
uniprot id: A0A6I8PPZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9258:LOC100074669
gene id: 9258:LOC100074669
uniprot id: F6T146
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9258:ATXN3
gene id: 9258:ATXN3
uniprot id: A0A6I8P6I7
uniprot id: A0A6I8P6W3
names: Subcellular Location Annotation
messages: Nucleus

9258:NSG2
gene id: 9258:NSG2
uniprot id: F7C8F3
names: Similarity
messages: Belongs to the NSG family.

9258:CDH18
gene id: 9258:CDH18
uniprot id: F6VFP8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9258:LOC100681801
gene id: 9258:LOC100681801
uniprot id: F7G5R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100093148
gene id: 9258:LOC100093148
uniprot id: A0A6I8PF82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:TVP23B
gene id: 9258:TVP23B
uniprot id: A0A6I8NHA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9258:DKK4
gene id: 9258:DKK4
uniprot id: F7CGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9258:KCNJ3
gene id: 9258:KCNJ3
uniprot id: A0A6I8NVL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

9258:OVOL1
gene id: 9258:OVOL1
uniprot id: A0A6I8PIN9
names: Subcellular Location Annotation
messages: Nucleus

9258:PRDM1
gene id: 9258:PRDM1
uniprot id: A0A6I8PJN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9258:ARL6
gene id: 9258:ARL6
uniprot id: A0A6I8NYD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9258:PAM16
gene id: 9258:PAM16
uniprot id: F6ZIB8
names: Similarity
messages: Belongs to the TIM16/PAM16 family.

9258:ALDH1A1
gene id: 9258:ALDH1A1
uniprot id: F6T2M0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9258:PELI1
gene id: 9258:PELI1
uniprot id: F7DJM8
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9258:GJB2
gene id: 9258:GJB2
uniprot id: F7ETY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9258:ALAS1
gene id: 9258:ALAS1
uniprot id: F7BXN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9258:GPX8
gene id: 9258:GPX8
uniprot id: F7BT71
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9258:HOXA7
gene id: 9258:HOXA7
uniprot id: A0A6I8P3C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9258:GSX1
gene id: 9258:GSX1
uniprot id: A0A6I8NQM0
names: Subcellular Location Annotation
messages: Nucleus

9258:ANXA1
gene id: 9258:ANXA1
uniprot id: A0A6I8N6Y6
uniprot id: F6T207
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9258:MED17
gene id: 9258:MED17
uniprot id: K7EEF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9258:DOCK2
gene id: 9258:DOCK2
uniprot id: F6Y0N2
names: Similarity
messages: Belongs to the DOCK family.

9258:BPNT1
gene id: 9258:BPNT1
uniprot id: A0A6I8NC13
uniprot id: F7GEC3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9258:S1PR1
gene id: 9258:S1PR1
uniprot id: F6ZG05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:EIF3L
gene id: 9258:EIF3L
uniprot id: F6Z936
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9258:KCNU1
gene id: 9258:KCNU1
uniprot id: F7F3A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Membrane

9258:PPIB
gene id: 9258:PPIB
uniprot id: F7DYN1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9258:E2F8
gene id: 9258:E2F8
uniprot id: F7DFN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9258:LAMTOR4
gene id: 9258:LAMTOR4
uniprot id: K7E914
names: Similarity
messages: Belongs to the LAMTOR4 family.

9258:CTPS2
gene id: 9258:CTPS2
uniprot id: A0A6I8N6X5
uniprot id: K7EHT6
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9258:YWHAZ
gene id: 9258:YWHAZ
uniprot id: A0A6I8NI84
names: Similarity
messages: Belongs to the 14-3-3 family.

9258:IL26
gene id: 9258:IL26
uniprot id: F6PQV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9258:AFG1L
gene id: 9258:AFG1L
uniprot id: F6WT91
names: Similarity
messages: Belongs to the AFG1 ATPase family.

9258:LOC100083945
gene id: 9258:LOC100083945
uniprot id: A0A6I8NC23
uniprot id: F6Z742
names: Similarity
messages: Belongs to the EVA1 family.

9258:HSPA2
gene id: 9258:HSPA2
uniprot id: F6ZXI7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9258:UPF1
gene id: 9258:UPF1
uniprot id: F7E547
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

9258:LOC100088038
gene id: 9258:LOC100088038
uniprot id: F7FPB8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9258:LSM6
gene id: 9258:LSM6
uniprot id: A0A6I8P8S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9258:SIRT4
gene id: 9258:SIRT4
uniprot id: F7A153
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

9258:LOC100090511
gene id: 9258:LOC100090511
uniprot id: F6UWZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:IFN3
gene id: 9258:IFN3
uniprot id: A8E6D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9258:ATP6V1C2
gene id: 9258:ATP6V1C2
uniprot id: A0A6I8P6X8
uniprot id: A0A6I8PMY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9258:SERPINI1
gene id: 9258:SERPINI1
uniprot id: F7CJ66
names: Similarity
messages: Belongs to the serpin family.

9258:IL15
gene id: 9258:IL15
uniprot id: A0A6I8PI77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9258:RPGRIP1L
gene id: 9258:RPGRIP1L
uniprot id: F7D409
names: Similarity
messages: Belongs to the RPGRIP1 family.

9258:SH3GL2
gene id: 9258:SH3GL2
uniprot id: F6VBU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9258:ADD3
gene id: 9258:ADD3
uniprot id: A0A6I8NBA3
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9258:STMN3
gene id: 9258:STMN3
uniprot id: F7E2A0
names: Similarity
messages: Belongs to the stathmin family.

9258:SEC13
gene id: 9258:SEC13
uniprot id: F7GBF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane

9258:TMEM159
gene id: 9258:TMEM159
uniprot id: F6R151
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9258:LOC100076505
gene id: 9258:LOC100076505
uniprot id: F6PQB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

9258:LOC100088880
gene id: 9258:LOC100088880
uniprot id: F6W4A9
names: Similarity
messages: Belongs to the intermediate filament family.

9258:WASF3
gene id: 9258:WASF3
uniprot id: F7D261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9258:ORNANAV1R3127
gene id: 9258:ORNANAV1R3127
uniprot id: F7FMP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:SLC16A9
gene id: 9258:SLC16A9
uniprot id: F6WBT5
names: Subcellular Location Annotation
messages: Membrane

9258:SATB1
gene id: 9258:SATB1
uniprot id: F7GBA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9258:LOC100090050
gene id: 9258:LOC100090050
uniprot id: F7ELE1
names: Subcellular Location Annotation
messages: Membrane

9258:ERH
gene id: 9258:ERH
uniprot id: A0A6I8NNG7
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9258:FGF14
gene id: 9258:FGF14
uniprot id: F7CTN6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9258:ORNANAV1R3265
gene id: 9258:ORNANAV1R3265
uniprot id: A0A6I8MYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100089405
gene id: 9258:LOC100089405
uniprot id: F7BNM6
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9258:LOC100082926
gene id: 9258:LOC100082926
uniprot id: F7CUM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9258:PPP1CC
gene id: 9258:PPP1CC
uniprot id: A0A6I8P341
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.

9258:SLC12A7
gene id: 9258:SLC12A7
uniprot id: A0A6I8P3C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9258:HPRT1
gene id: 9258:HPRT1
uniprot id: F7AT83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9258:GBX2
gene id: 9258:GBX2
uniprot id: A0A6I8PE44
names: Subcellular Location Annotation
messages: Nucleus

9258:BBS7
gene id: 9258:BBS7
uniprot id: F6XU90
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9258:ORNANAV1R3019
gene id: 9258:ORNANAV1R3019
uniprot id: A0A6I8N3K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:B3GNT9
gene id: 9258:B3GNT9
uniprot id: F7G6U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9258:ORNANAV1R3015
gene id: 9258:ORNANAV1R3015
uniprot id: F6RJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:DOCK9
gene id: 9258:DOCK9
uniprot id: A0A6I8NVP1
names: Similarity
messages: Belongs to the DOCK family.

9258:IL1F10
gene id: 9258:IL1F10
uniprot id: F6U6R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9258:FAM76A
gene id: 9258:FAM76A
uniprot id: A0A6I8NN60
names: Similarity
messages: Belongs to the FAM76 family.

9258:ITIH2
gene id: 9258:ITIH2
uniprot id: F6PWM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9258:GEMIN2
gene id: 9258:GEMIN2
uniprot id: F6SYB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

9258:UGP2
gene id: 9258:UGP2
uniprot id: F7DK07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9258:PSEN2
gene id: 9258:PSEN2
uniprot id: F7AD40
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

9258:IGF2R
gene id: 9258:IGF2R
uniprot id: Q9N1T0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:UCKL1
gene id: 9258:UCKL1
uniprot id: A0A6I8PBR9
uniprot id: K7EH62
names: Similarity
messages: Belongs to the uridine kinase family.

9258:KEF28 p01
gene id: 9258:KEF28_p01
uniprot id: G8CUI0
uniprot id: Q36461
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9258:LOC100083043
gene id: 9258:LOC100083043
uniprot id: A0A6I8N3W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:NDNF
gene id: 9258:NDNF
uniprot id: F7BV77
names: Subcellular Location Annotation
messages: Secreted

9258:LOC100078234
gene id: 9258:LOC100078234
uniprot id: F6Y2D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9258:DKK1
gene id: 9258:DKK1
uniprot id: F7G5A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9258:SNAP91
gene id: 9258:SNAP91
uniprot id: A0A6I8NLX4
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9258:SLC12A4
gene id: 9258:SLC12A4
uniprot id: F6Z596
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9258:FLCN
gene id: 9258:FLCN
uniprot id: F7G936
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9258:EPYC
gene id: 9258:EPYC
uniprot id: F7C656
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9258:CTU1
gene id: 9258:CTU1
uniprot id: A0A6I8NIT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9258:NPL
gene id: 9258:NPL
uniprot id: F6WPI3
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Homotetramer.

9258:PLRG1
gene id: 9258:PLRG1
uniprot id: F7CSR0
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9258:DIPK2B
gene id: 9258:DIPK2B
uniprot id: A0A6I8PQJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9258:GPC4
gene id: 9258:GPC4
uniprot id: F7A1I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9258:LOC100076703
gene id: 9258:LOC100076703
uniprot id: A0A6I8NCA1
names: Similarity
messages: Belongs to the actin family.

9258:SLC25A30
gene id: 9258:SLC25A30
uniprot id: A0A6I8NJ36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9258:CPEB1
gene id: 9258:CPEB1
uniprot id: F7DY93
names: Similarity
messages: Belongs to the RRM CPEB family.

9258:HSPB3
gene id: 9258:HSPB3
uniprot id: F7BHG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9258:LOC100091681
gene id: 9258:LOC100091681
uniprot id: A0A6I8NIA8
names: Similarity
messages: Belongs to the intermediate filament family.

9258:LOC100086479
gene id: 9258:LOC100086479
uniprot id: F7EDJ6
names: Subcellular Location Annotation
messages: Membrane

9258:LOC100080559
gene id: 9258:LOC100080559
uniprot id: A0A6I8NIV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9258:SSBP2
gene id: 9258:SSBP2
uniprot id: A0A6I8N6N7
names: Subcellular Location Annotation
messages: Nucleus

9258:CDSN
gene id: 9258:CDSN
uniprot id: A7X5Y4
names: Function
names: Subcellular Location Annotation
messages: Important for the epidermal barrier integrity.
messages: Secreted

9258:CHD9
gene id: 9258:CHD9
uniprot id: A0A6I8NAP3
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9258:LOC100083024
gene id: 9258:LOC100083024
uniprot id: F7GAI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100083139
gene id: 9258:LOC100083139
uniprot id: F7GA92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:HTR2B
gene id: 9258:HTR2B
uniprot id: F7CYI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9258:CRH
gene id: 9258:CRH
uniprot id: F7AJN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9258:WLS
gene id: 9258:WLS
uniprot id: F7CMJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9258:LOC100093301
gene id: 9258:LOC100093301
uniprot id: F7DNX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:G6PC2
gene id: 9258:G6PC2
uniprot id: F6XKK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9258:IFNK
gene id: 9258:IFNK
uniprot id: A8E6D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9258:SGCD
gene id: 9258:SGCD
uniprot id: F7C7E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9258:LSM8
gene id: 9258:LSM8
uniprot id: A0A6I8P7M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9258:MAEL
gene id: 9258:MAEL
uniprot id: I7AUV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9258:LOC100087154
gene id: 9258:LOC100087154
uniprot id: F7CK40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100087904
gene id: 9258:LOC100087904
uniprot id: A0A6I8PEV3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9258:ADIPOR2
gene id: 9258:ADIPOR2
uniprot id: F7F368
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9258:CPLX4
gene id: 9258:CPLX4
uniprot id: F7DHB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9258:CX3CR1
gene id: 9258:CX3CR1
uniprot id: F6S8I2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9258:LOC100680627
gene id: 9258:LOC100680627
uniprot id: A0A6I8N0T8
names: Subcellular Location Annotation
messages: Membrane

9258:CHRD
gene id: 9258:CHRD
uniprot id: F7EWG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
messages: Secreted

9258:GGPS1
gene id: 9258:GGPS1
uniprot id: F6Z6V4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9258:NEUROD6
gene id: 9258:NEUROD6
uniprot id: F6YI28
names: Subcellular Location Annotation
messages: Nucleus

9258:ANKS1B
gene id: 9258:ANKS1B
uniprot id: A0A6I8NGM2
names: Subcellular Location Annotation
messages: Cytoplasm

9258:CCDC172
gene id: 9258:CCDC172
uniprot id: F7GA98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

9258:ORC4
gene id: 9258:ORC4
uniprot id: F6XN20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

9258:RPS24
gene id: 9258:RPS24
uniprot id: A0A6I8NL26
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

9258:PLP2
gene id: 9258:PLP2
uniprot id: F7FWB7
names: Subcellular Location Annotation
messages: Membrane

9258:HOXA6
gene id: 9258:HOXA6
uniprot id: F7EBY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9258:SLC10A2
gene id: 9258:SLC10A2
uniprot id: F7GEX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9258:TNFAIP6
gene id: 9258:TNFAIP6
uniprot id: A0A6I8NT24
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:SMIM12
gene id: 9258:SMIM12
uniprot id: F6THT1
names: Similarity
messages: Belongs to the SMIM12 family.

9258:DNAJA4
gene id: 9258:DNAJA4
uniprot id: A0A6I8PAC0
names: Subcellular Location Annotation
messages: Membrane

9258:CALCB
gene id: 9258:CALCB
uniprot id: A0A6I8NSJ0
names: Similarity
messages: Belongs to the calcitonin family.

9258:CCNB2
gene id: 9258:CCNB2
uniprot id: F7DBI2
names: Similarity
messages: Belongs to the cyclin family.

9258:YIPF5
gene id: 9258:YIPF5
uniprot id: F6W544
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9258:NUDT4
gene id: 9258:NUDT4
uniprot id: A0A6I8PER4
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9258:ARG1
gene id: 9258:ARG1
uniprot id: F6SK57
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9258:BARX1
gene id: 9258:BARX1
uniprot id: A0A6I8NUJ9
names: Subcellular Location Annotation
messages: Nucleus

9258:LOC100529072
gene id: 9258:LOC100529072
uniprot id: A7X5N1
names: Similarity
messages: Belongs to the MHC class I family.

9258:ABITRAM
gene id: 9258:ABITRAM
uniprot id: F7E8J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9258:LOC100680941
gene id: 9258:LOC100680941
uniprot id: F7G4B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:BIRC7
gene id: 9258:BIRC7
uniprot id: K7E8R5
names: Similarity
messages: Belongs to the IAP family.

9258:EHF
gene id: 9258:EHF
uniprot id: A0A6I8NHK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9258:PRKCQ
gene id: 9258:PRKCQ
uniprot id: F6PVR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9258:IL5
gene id: 9258:IL5
uniprot id: A0A6I8P6S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9258:KITLG
gene id: 9258:KITLG
uniprot id: A0A6I8NLQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

9258:SLC17A9
gene id: 9258:SLC17A9
uniprot id: A0A6I8PKM2
names: Subcellular Location Annotation
messages: Membrane

9258:POLR2H
gene id: 9258:POLR2H
uniprot id: A0A6I8N3L3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9258:ORNANAV1R3162
gene id: 9258:ORNANAV1R3162
uniprot id: A0A6I8MZT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100077905
gene id: 9258:LOC100077905
uniprot id: F7F417
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9258:KCNJ13
gene id: 9258:KCNJ13
uniprot id: F7BZF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9258:VAPB
gene id: 9258:VAPB
uniprot id: A0A6I8NTW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:UTP25
gene id: 9258:UTP25
uniprot id: F7CDG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9258:CHMP4C
gene id: 9258:CHMP4C
uniprot id: F7G5G6
names: Similarity
messages: Belongs to the SNF7 family.

9258:ETFRF1
gene id: 9258:ETFRF1
uniprot id: F7FN02
names: Similarity
messages: Belongs to the complex I LYR family.

9258:RPL17
gene id: 9258:RPL17
uniprot id: F7BUN9
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9258:LOC100077007
gene id: 9258:LOC100077007
uniprot id: F7GEM4
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9258:CMBL
gene id: 9258:CMBL
uniprot id: F6Z9U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9258:LOC100079007
gene id: 9258:LOC100079007
uniprot id: F7B2W9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9258:LOC100077291
gene id: 9258:LOC100077291
uniprot id: A0A6I8MZN6
uniprot id: F6WS06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9258:PPM1A
gene id: 9258:PPM1A
uniprot id: F6ZZ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9258:CD99
gene id: 9258:CD99
uniprot id: A0A6I8NVW1
names: Similarity
messages: Belongs to the CD99 family.

9258:PSMB8
gene id: 9258:PSMB8
uniprot id: A7X5P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9258:TMEM45B
gene id: 9258:TMEM45B
uniprot id: F7FBF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9258:IDO1
gene id: 9258:IDO1
uniprot id: B3Y9H6
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9258:RPL32
gene id: 9258:RPL32
uniprot id: A0A6I8P6I6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9258:OXT
gene id: 9258:OXT
uniprot id: F7BNK7
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9258:GTPBP3
gene id: 9258:GTPBP3
uniprot id: F7FGZ6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

9258:SPO11
gene id: 9258:SPO11
uniprot id: A0A6I8PG29
names: Similarity
messages: Belongs to the TOP6A family.

9258:KEF28 p04
gene id: 9258:KEF28_p04
uniprot id: A0A6Q7HQX5
uniprot id: Q36458
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9258:PTPN14
gene id: 9258:PTPN14
uniprot id: F6WMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9258:SLC16A1
gene id: 9258:SLC16A1
uniprot id: A0A6I8NF12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9258:ORNANAV1R3061
gene id: 9258:ORNANAV1R3061
uniprot id: A0A6I8NAD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:SST
gene id: 9258:SST
uniprot id: F6XMG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9258:SRP9
gene id: 9258:SRP9
uniprot id: A0A6I8N7Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9258:LOC100093370
gene id: 9258:LOC100093370
uniprot id: F7DNX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:ARHGEF6
gene id: 9258:ARHGEF6
uniprot id: F6RAG9
names: Subcellular Location Annotation
messages: lamellipodium

9258:LOC100085529
gene id: 9258:LOC100085529
uniprot id: A0A6I8P024
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9258:C1D
gene id: 9258:C1D
uniprot id: A0A6I8NFX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9258:LOC100084369
gene id: 9258:LOC100084369
uniprot id: F7CAQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

9258:CA3
gene id: 9258:CA3
uniprot id: F7BGY6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9258:RER1
gene id: 9258:RER1
uniprot id: F7G589
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9258:C3H10orf53
gene id: 9258:C3H10orf53
uniprot id: F6Z7Q6
names: Similarity
messages: Belongs to the UPF0728 family.

9258:ALX1
gene id: 9258:ALX1
uniprot id: F6Y859
names: Subcellular Location Annotation
messages: Nucleus

9258:G6PD
gene id: 9258:G6PD
uniprot id: A0A6I8PJK2
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

9258:LOC100093165
gene id: 9258:LOC100093165
uniprot id: F6QTF3
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:CNOT2
gene id: 9258:CNOT2
uniprot id: A0A6I8PGC9
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9258:LOC100093308
gene id: 9258:LOC100093308
uniprot id: A0A6I8N7N1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:SURF4
gene id: 9258:SURF4
uniprot id: A0A6I8NH26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:LOC100085065
gene id: 9258:LOC100085065
uniprot id: F7C0F4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9258:SNAPC3
gene id: 9258:SNAPC3
uniprot id: F7FE29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

9258:SRXN1
gene id: 9258:SRXN1
uniprot id: A0A6I8PBI0
names: Similarity
messages: Belongs to the sulfiredoxin family.

9258:LFNG
gene id: 9258:LFNG
uniprot id: F6SZM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9258:LOC100082293
gene id: 9258:LOC100082293
uniprot id: F7DSP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9258:SEPTIN8
gene id: 9258:SEPTIN8
uniprot id: F6YNV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9258:GPER1
gene id: 9258:GPER1
uniprot id: F6TC29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100093170
gene id: 9258:LOC100093170
uniprot id: A0A6I8P814
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:ACP1
gene id: 9258:ACP1
uniprot id: A0A6I8PKY2
uniprot id: F6RX59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9258:TMEM50A
gene id: 9258:TMEM50A
uniprot id: F6SWE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9258:APPL2
gene id: 9258:APPL2
uniprot id: F6RTD8
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9258:HTR1F
gene id: 9258:HTR1F
uniprot id: F7EPA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

9258:OPN1MW3
gene id: 9258:OPN1MW3
uniprot id: A4ZIT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9258:LOC100093255
gene id: 9258:LOC100093255
uniprot id: F7CNK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9258:SLC35F6
gene id: 9258:SLC35F6
uniprot id: F7D6B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9258:LOC100087130
gene id: 9258:LOC100087130
uniprot id: P01979
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

9258:FOXL3
gene id: 9258:FOXL3
uniprot id: F7CXI5
names: Subcellular Location Annotation
messages: Nucleus

9258:CLCN4
gene id: 9258:CLCN4
uniprot id: F6SKL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9258:HOXD12
gene id: 9258:HOXD12
uniprot id: F7G0M4
names: Subcellular Location Annotation
messages: Nucleus

9258:ASF1B
gene id: 9258:ASF1B
uniprot id: A0A6I8PGW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9258:LOC100079619
gene id: 9258:LOC100079619
uniprot id: F7EXB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9258:DHX9
gene id: 9258:DHX9
uniprot id: F6WPG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9258:ORNANAV1R3263
gene id: 9258:ORNANAV1R3263
uniprot id: A0A6I8MY91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:MC2R
gene id: 9258:MC2R
uniprot id: F7FM99
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

9258:DAZL
gene id: 9258:DAZL
uniprot id: F7CS82
names: Subcellular Location Annotation
messages: Cytoplasm

9258:DNAJA1
gene id: 9258:DNAJA1
uniprot id: A0A6I8PND9
names: Subcellular Location Annotation
messages: Membrane

9258:CALHM5
gene id: 9258:CALHM5
uniprot id: F6URF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9258:PTGS2
gene id: 9258:PTGS2
uniprot id: A0A6I8P4L4
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:LOC107547808
gene id: 9258:LOC107547808
uniprot id: F6YN49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:ABL1
gene id: 9258:ABL1
uniprot id: A0A6I8PFF6
uniprot id: F6QCG8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9258:ORNANAV1R3264
gene id: 9258:ORNANAV1R3264
uniprot id: A0A6I8PB87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:MRPL32
gene id: 9258:MRPL32
uniprot id: A0A6I8NU47
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9258:NACC2
gene id: 9258:NACC2
uniprot id: F6V793
names: Subcellular Location Annotation
messages: Nucleus

9258:RPL14
gene id: 9258:RPL14
uniprot id: A0A6I8PKY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9258:POLR2G
gene id: 9258:POLR2G
uniprot id: F6PS64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9258:TSPAN8
gene id: 9258:TSPAN8
uniprot id: F6SXL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9258:SMAD4
gene id: 9258:SMAD4
uniprot id: F7F4A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9258:RPL7L1
gene id: 9258:RPL7L1
uniprot id: F6PJ74
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9258:ACTB
gene id: 9258:ACTB
uniprot id: F6UDX9
names: Similarity
messages: Belongs to the actin family.

9258:LOC100076573
gene id: 9258:LOC100076573
uniprot id: A0A6I8NR60
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9258:ORNANAV1R3005
gene id: 9258:ORNANAV1R3005
uniprot id: F7BJA5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9258:TNFSF10
gene id: 9258:TNFSF10
uniprot id: F7CZ84
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9258:PWWP3A
gene id: 9258:PWWP3A
uniprot id: F7DUZ3
names: Similarity
messages: Belongs to the PWWP3A family.

9258:MRE11
gene id: 9258:MRE11
uniprot id: F6YRG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9258:BRS3
gene id: 9258:BRS3
uniprot id: F7BLI7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9258:LYZL4
gene id: 9258:LYZL4
uniprot id: F7D6D7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9258:RFLB
gene id: 9258:RFLB
uniprot id: B1AAR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9258:LOC100074817
gene id: 9258:LOC100074817
uniprot id: F6ZTJ8
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

9258:LOC100092128
gene id: 9258:LOC100092128
uniprot id: F6ST51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:OTUB2
gene id: 9258:OTUB2
uniprot id: F7DYW4
names: Similarity
messages: Belongs to the peptidase C65 family.

9258:GINS3
gene id: 9258:GINS3
uniprot id: A0A6I8P934
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9258:PRPF18
gene id: 9258:PRPF18
uniprot id: F6VC31
uniprot id: K7ECI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9258:MTX2
gene id: 9258:MTX2
uniprot id: F6WME1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9258:PMEPA1
gene id: 9258:PMEPA1
uniprot id: F7ESH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9258:NPTX2
gene id: 9258:NPTX2
uniprot id: F6Z568
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:ATP5F1A
gene id: 9258:ATP5F1A
uniprot id: F6V9Q4
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9258:SGCG
gene id: 9258:SGCG
uniprot id: A0A6I8N8U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9258:LOC100081707
gene id: 9258:LOC100081707
uniprot id: F6TVB3
names: Subcellular Location Annotation
messages: Membrane

9258:LOC100083188
gene id: 9258:LOC100083188
uniprot id: F7GA82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:ORNANAV1R3268
gene id: 9258:ORNANAV1R3268
uniprot id: A0A6I8NGV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TNFRSF19
gene id: 9258:TNFRSF19
uniprot id: A0A6I8NF11
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:NDUFA5
gene id: 9258:NDUFA5
uniprot id: F7E2X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9258:ORNANAV1R3198
gene id: 9258:ORNANAV1R3198
uniprot id: F7FME8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100077545
gene id: 9258:LOC100077545
uniprot id: F6Y1I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9258:LSM3
gene id: 9258:LSM3
uniprot id: F7DVJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9258:MYH11
gene id: 9258:MYH11
uniprot id: A0A6I8PB26
uniprot id: F6WFN3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9258:CXCL12
gene id: 9258:CXCL12
uniprot id: A0A6I8NGE9
names: Similarity
messages: Belongs to the intercrine alpha (chemokine CxC) family.

9258:OGN
gene id: 9258:OGN
uniprot id: F6X320
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9258:SKA3
gene id: 9258:SKA3
uniprot id: A0A6I8PR59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9258:CTTNBP2
gene id: 9258:CTTNBP2
uniprot id: Q07DZ5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.
messages: Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
messages: cell cortex
messages: dendritic spine

9258:ORNANAV1R3020
gene id: 9258:ORNANAV1R3020
uniprot id: A0A6I8NKG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:GUCY1A1
gene id: 9258:GUCY1A1
uniprot id: A0A6I8NUE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9258:ORNANAV1R3199
gene id: 9258:ORNANAV1R3199
uniprot id: A0A6I8P7Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:URAD
gene id: 9258:URAD
uniprot id: F7GDM5
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9258:SEPTIN2
gene id: 9258:SEPTIN2
uniprot id: F6T0Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: spindle

9258:ERG28
gene id: 9258:ERG28
uniprot id: A0A6I8MZB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:S100A4
gene id: 9258:S100A4
uniprot id: F6Q7T6
names: Similarity
messages: Belongs to the S-100 family.

9258:HADHA
gene id: 9258:HADHA
uniprot id: A0A6I8NUB2
uniprot id: F7EMK0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9258:HAPLN1
gene id: 9258:HAPLN1
uniprot id: F7EH86
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:FTH1
gene id: 9258:FTH1
uniprot id: F7E2N2
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9258:PDE5A
gene id: 9258:PDE5A
uniprot id: A0A6I8P3Y3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9258:LOC100074634
gene id: 9258:LOC100074634
uniprot id: F7DIZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9258:SFRP2
gene id: 9258:SFRP2
uniprot id: A0A6I8PNR4
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:LOC100093369
gene id: 9258:LOC100093369
uniprot id: F6PXE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9258:VPS29
gene id: 9258:VPS29
uniprot id: A0A6I8P3L8
uniprot id: F7FN67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9258:ORNANAV1R3244
gene id: 9258:ORNANAV1R3244
uniprot id: A0A6I8NI10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TRIM32
gene id: 9258:TRIM32
uniprot id: F6UML6
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9258:BORCS7
gene id: 9258:BORCS7
uniprot id: A0A6I8N861
uniprot id: F7D0T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Lysosome membrane
messages: Membrane

9258:MAB21L2
gene id: 9258:MAB21L2
uniprot id: F6UKL2
names: Similarity
messages: Belongs to the mab-21 family.

9258:HNRNPA2B1
gene id: 9258:HNRNPA2B1
uniprot id: F7EJK5
names: Subcellular Location Annotation
messages: Cytoplasmic granule

9258:TMEM208
gene id: 9258:TMEM208
uniprot id: A0A6I8PDP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9258:ACVR1
gene id: 9258:ACVR1
uniprot id: A0A6I8PDF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9258:STRADB
gene id: 9258:STRADB
uniprot id: K7EI25
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9258:LYRM1
gene id: 9258:LYRM1
uniprot id: F6Q5F2
names: Similarity
messages: Belongs to the complex I LYR family.

9258:GNG3
gene id: 9258:GNG3
uniprot id: A0A6I8PCY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9258:TIGD1
gene id: 9258:TIGD1
uniprot id: F7CP89
names: Subcellular Location Annotation
messages: Nucleus

9258:PORCN
gene id: 9258:PORCN
uniprot id: A0A6I8NJK4
uniprot id: F6QQ44
names: Subcellular Location Annotation
messages: Membrane

9258:LIMK2
gene id: 9258:LIMK2
uniprot id: A0A6I8N2M8
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9258:LOC100082917
gene id: 9258:LOC100082917
uniprot id: F7GAK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:METTL8
gene id: 9258:METTL8
uniprot id: F6PIF6
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9258:CTNNBIP1
gene id: 9258:CTNNBIP1
uniprot id: A0A6I8NZ31
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9258:SLC20A2
gene id: 9258:SLC20A2
uniprot id: A0A6I8MY49
uniprot id: F6ZED3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

9258:ORNANAV1R3193
gene id: 9258:ORNANAV1R3193
uniprot id: A0A6I8P3H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:CYRIB
gene id: 9258:CYRIB
uniprot id: F7FXY9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9258:LAMP5
gene id: 9258:LAMP5
uniprot id: F6VV53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Membrane

9258:MMAA
gene id: 9258:MMAA
uniprot id: F6YA49
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

9258:ORNANAV1R3046
gene id: 9258:ORNANAV1R3046
uniprot id: A0A6I8N4Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100078431
gene id: 9258:LOC100078431
uniprot id: F7E542
names: Similarity
messages: Belongs to the TGF-beta family.

9258:LOC100080622
gene id: 9258:LOC100080622
uniprot id: A0A6I8PF82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:BBOX1
gene id: 9258:BBOX1
uniprot id: A0A6I8NRD9
names: Function
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

9258:COPB1
gene id: 9258:COPB1
uniprot id: F7C3B7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9258:DPYSL3
gene id: 9258:DPYSL3
uniprot id: F7DIK9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9258:FER
gene id: 9258:FER
uniprot id: F6SAV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9258:GDF2
gene id: 9258:GDF2
uniprot id: F6UER7
names: Similarity
messages: Belongs to the TGF-beta family.

9258:ITGA6
gene id: 9258:ITGA6
uniprot id: F7CBN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9258:GJB3
gene id: 9258:GJB3
uniprot id: F6TGG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9258:ATP5MC3
gene id: 9258:ATP5MC3
uniprot id: A0A6I8NEJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9258:PAX1
gene id: 9258:PAX1
uniprot id: F6SX13
names: Subcellular Location Annotation
messages: Nucleus

9258:SEMA3D
gene id: 9258:SEMA3D
uniprot id: F7AVT1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:MAB21L1
gene id: 9258:MAB21L1
uniprot id: F7B8L8
names: Similarity
messages: Belongs to the mab-21 family.

9258:LZIC
gene id: 9258:LZIC
uniprot id: F7EKH8
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9258:ORNANAV1R3228
gene id: 9258:ORNANAV1R3228
uniprot id: A0A6I8NPP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:ANAPC10
gene id: 9258:ANAPC10
uniprot id: F7DUE6
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9258:LOC100083559
gene id: 9258:LOC100083559
uniprot id: F6REZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Secreted

9258:CDCA7
gene id: 9258:CDCA7
uniprot id: F7CB81
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9258:CAV1
gene id: 9258:CAV1
uniprot id: Q07E02
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).
messages: May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).
messages: Membrane raft
messages: Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
messages: Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response.
messages: caveola

9258:CHRNA1
gene id: 9258:CHRNA1
uniprot id: F6XJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9258:CDC34
gene id: 9258:CDC34
uniprot id: F7F5T2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9258:KEF28 p12
gene id: 9258:KEF28_p12
uniprot id: Q36451
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9258:TAP2
gene id: 9258:TAP2
uniprot id: A7X5N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

9258:LOC100092015
gene id: 9258:LOC100092015
uniprot id: F6Y184
names: Similarity
messages: Belongs to the adenylate kinase family.

9258:LHFPL6
gene id: 9258:LHFPL6
uniprot id: F6X1Z4
names: Subcellular Location Annotation
messages: Membrane

9258:LOC100077537
gene id: 9258:LOC100077537
uniprot id: F6PSU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9258:TNFSF8
gene id: 9258:TNFSF8
uniprot id: F7A8A3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9258:DLK1
gene id: 9258:DLK1
uniprot id: B5LY07
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:RSAD2
gene id: 9258:RSAD2
uniprot id: A0A6I8N6S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

9258:CLCN3
gene id: 9258:CLCN3
uniprot id: A0A6I8NIL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9258:LOC100681347
gene id: 9258:LOC100681347
uniprot id: A0A6I8MZ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9258:RPL13A
gene id: 9258:RPL13A
uniprot id: F6PKE7
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9258:GPR50
gene id: 9258:GPR50
uniprot id: A0A2P1K6N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:RNASE13
gene id: 9258:RNASE13
uniprot id: F6V3S6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9258:RAB9A
gene id: 9258:RAB9A
uniprot id: F7E148
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9258:BASP1
gene id: 9258:BASP1
uniprot id: A0A6I8NDF1
names: Similarity
messages: Belongs to the BASP1 family.

9258:SFXN1
gene id: 9258:SFXN1
uniprot id: A0A6I8NMP4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9258:BLOC1S3
gene id: 9258:BLOC1S3
uniprot id: F6T469
names: Similarity
messages: Belongs to the BLOC1S3 family.

9258:ORNANAV1R3220
gene id: 9258:ORNANAV1R3220
uniprot id: A0A6I8P4Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:UGT8
gene id: 9258:UGT8
uniprot id: A0A6I8PJ24
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9258:CDR2
gene id: 9258:CDR2
uniprot id: A0A6I8P0S9
names: Similarity
messages: Belongs to the CDR2 family.

9258:LOC100087008
gene id: 9258:LOC100087008
uniprot id: F6QAR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TSPAN12
gene id: 9258:TSPAN12
uniprot id: A0A6I8P367
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9258:EDN1
gene id: 9258:EDN1
uniprot id: F6WZM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9258:LOC100078521
gene id: 9258:LOC100078521
uniprot id: F6Z4D6
names: Similarity
messages: Belongs to the intermediate filament family.

9258:BCL2A1
gene id: 9258:BCL2A1
uniprot id: F6S8G3
names: Similarity
messages: Belongs to the Bcl-2 family.

9258:SF3B3
gene id: 9258:SF3B3
uniprot id: A0A6I8P9Z8
names: Subcellular Location Annotation
messages: Nucleus

9258:KATNAL1
gene id: 9258:KATNAL1
uniprot id: A0A6I8MZY0
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9258:EEF1AKMT1
gene id: 9258:EEF1AKMT1
uniprot id: F7EL08
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

9258:ELK3
gene id: 9258:ELK3
uniprot id: A0A6I8N8F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9258:STX19
gene id: 9258:STX19
uniprot id: F7EXD2
names: Similarity
messages: Belongs to the syntaxin family.

9258:GTF2H2
gene id: 9258:GTF2H2
uniprot id: F7G7T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9258:TLR8
gene id: 9258:TLR8
uniprot id: A0A6I8NGX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9258:TMEM267
gene id: 9258:TMEM267
uniprot id: A0A6I8PML4
names: Subcellular Location Annotation
messages: Membrane

9258:GNGT1
gene id: 9258:GNGT1
uniprot id: A0A6I8P150
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9258:NUP93
gene id: 9258:NUP93
uniprot id: F7F915
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9258:MB
gene id: 9258:MB
uniprot id: P02196
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9258:LOC100093280
gene id: 9258:LOC100093280
uniprot id: A0A6I8P814
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:JPT2
gene id: 9258:JPT2
uniprot id: A0A6I8NU72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9258:COQ7
gene id: 9258:COQ7
uniprot id: K7EG75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9258:ELAC1
gene id: 9258:ELAC1
uniprot id: A0A6I8NUK4
names: Subunit
messages: Homodimer.

9258:TMEM129
gene id: 9258:TMEM129
uniprot id: F6TNU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9258:KPNA2
gene id: 9258:KPNA2
uniprot id: F6RK29
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9258:PXMP2
gene id: 9258:PXMP2
uniprot id: F6ZG20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9258:LIMS2
gene id: 9258:LIMS2
uniprot id: A0A6I8NN98
uniprot id: F7G857
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9258:SPARC
gene id: 9258:SPARC
uniprot id: F6YAF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

9258:LOC107547714
gene id: 9258:LOC107547714
uniprot id: A0A6I8P819
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9258:LIPG
gene id: 9258:LIPG
uniprot id: F6VS71
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9258:ARL5B
gene id: 9258:ARL5B
uniprot id: A0A6I8P646
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9258:CNDP1
gene id: 9258:CNDP1
uniprot id: F7FI95
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9258:MRPL13
gene id: 9258:MRPL13
uniprot id: F7G4R8
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9258:LOC100077615
gene id: 9258:LOC100077615
uniprot id: F7F337
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9258:TNFSF9
gene id: 9258:TNFSF9
uniprot id: A0A6I8NLA5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9258:ORNANAV1R3067
gene id: 9258:ORNANAV1R3067
uniprot id: F7DYA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:ORNANAV1R3181
gene id: 9258:ORNANAV1R3181
uniprot id: A0A6I8NYU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:C3H11orf58
gene id: 9258:C3H11orf58
uniprot id: A0A6I8PR99
names: Similarity
messages: Belongs to the SMAP family.

9258:LOC100077475
gene id: 9258:LOC100077475
uniprot id: A0A6I8NRH3
names: Similarity
messages: Belongs to the folate receptor family.

9258:DCN
gene id: 9258:DCN
uniprot id: F7C682
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

9258:GCNT4
gene id: 9258:GCNT4
uniprot id: F7FXW1
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9258:DNAJA2
gene id: 9258:DNAJA2
uniprot id: F7AM31
names: Subcellular Location Annotation
messages: Membrane

9258:CZIB
gene id: 9258:CZIB
uniprot id: F7F239
names: Similarity
messages: Belongs to the UPF0587 family.

9258:LOC100080393
gene id: 9258:LOC100080393
uniprot id: F7FG77
names: Subcellular Location Annotation
messages: Membrane

9258:LOC100084359
gene id: 9258:LOC100084359
uniprot id: A0A6I8PI95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:ADRM1
gene id: 9258:ADRM1
uniprot id: F6VAL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

9258:BFSP1
gene id: 9258:BFSP1
uniprot id: A0A6I8NPL3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

9258:GNRHR
gene id: 9258:GNRHR
uniprot id: B2BF83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:CAVIN4
gene id: 9258:CAVIN4
uniprot id: F7E8I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9258:ORNANAV1R3053
gene id: 9258:ORNANAV1R3053
uniprot id: A0A6I8N3Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:OLFM1
gene id: 9258:OLFM1
uniprot id: A0A6I8P4Z3
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9258:EPHA2
gene id: 9258:EPHA2
uniprot id: F6WYZ6
names: Subcellular Location Annotation
messages: Membrane

9258:TSC22D1
gene id: 9258:TSC22D1
uniprot id: F7DRV8
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9258:TAF7L
gene id: 9258:TAF7L
uniprot id: F7BKV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9258:LOC100078019
gene id: 9258:LOC100078019
uniprot id: F6PLK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

9258:UGDH
gene id: 9258:UGDH
uniprot id: F6RM31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9258:MRPL2
gene id: 9258:MRPL2
uniprot id: F6QEF8
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9258:NDUFA2
gene id: 9258:NDUFA2
uniprot id: F6RB25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9258:LOC100681826
gene id: 9258:LOC100681826
uniprot id: F6UMS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:KCNE2
gene id: 9258:KCNE2
uniprot id: F6ZQI9
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9258:PAFAH1B1
gene id: 9258:PAFAH1B1
uniprot id: F6PQP7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: centrosome
messages: cytoskeleton
messages: spindle

9258:PIK3CA
gene id: 9258:PIK3CA
uniprot id: F7DUD6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9258:LOC100092796
gene id: 9258:LOC100092796
uniprot id: F7A524
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:SENP7
gene id: 9258:SENP7
uniprot id: F6PP50
names: Similarity
messages: Belongs to the peptidase C48 family.

9258:SMC5
gene id: 9258:SMC5
uniprot id: F7FZ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9258:YME1L1
gene id: 9258:YME1L1
uniprot id: F6QLB9
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9258:CHRNA4
gene id: 9258:CHRNA4
uniprot id: F7DET6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9258:HMGCS1
gene id: 9258:HMGCS1
uniprot id: A0A6I8NH90
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9258:SEC61A2
gene id: 9258:SEC61A2
uniprot id: F6UDU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:LOC100073952
gene id: 9258:LOC100073952
uniprot id: F6ULR0
names: Similarity
messages: Belongs to the serpin family.

9258:CCT5
gene id: 9258:CCT5
uniprot id: F6Z9V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9258:PRR5L
gene id: 9258:PRR5L
uniprot id: F6S652
names: Similarity
messages: Belongs to the PROTOR family.

9258:CACNA2D1
gene id: 9258:CACNA2D1
uniprot id: A0A6I8PGU1
uniprot id: F7FSJ0
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9258:ORNANAV1R3124
gene id: 9258:ORNANAV1R3124
uniprot id: F6SSY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TSSK2
gene id: 9258:TSSK2
uniprot id: F7CS33
names: Similarity
messages: Belongs to the protein kinase superfamily.

9258:OSTC
gene id: 9258:OSTC
uniprot id: F6XNQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9258:PCYOX1L
gene id: 9258:PCYOX1L
uniprot id: F7FAU5
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9258:NRN1L
gene id: 9258:NRN1L
uniprot id: A0A6I8N569
names: Similarity
messages: Belongs to the neuritin family.

9258:CSNK2A2
gene id: 9258:CSNK2A2
uniprot id: F7F9Q9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9258:GLO1
gene id: 9258:GLO1
uniprot id: A0A6I8NKC9
names: Cofactor
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

9258:TTYH3
gene id: 9258:TTYH3
uniprot id: F6SZA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9258:TAGLN3
gene id: 9258:TAGLN3
uniprot id: A0A6I8P7A6
names: Similarity
messages: Belongs to the calponin family.

9258:RBP1
gene id: 9258:RBP1
uniprot id: F7ACB8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9258:SULT1E1
gene id: 9258:SULT1E1
uniprot id: K7E9W5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9258:B3GNT2
gene id: 9258:B3GNT2
uniprot id: F7DKD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9258:MAP2K3
gene id: 9258:MAP2K3
uniprot id: A0A6I8NJZ7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9258:LOC100078901
gene id: 9258:LOC100078901
uniprot id: F7B3E4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9258:KMO
gene id: 9258:KMO
uniprot id: F6UAQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane

9258:LOC103170567
gene id: 9258:LOC103170567
uniprot id: F7EQX0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

9258:CDH10
gene id: 9258:CDH10
uniprot id: F6VET9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9258:LOC100090373
gene id: 9258:LOC100090373
uniprot id: A0A6I8N3Y6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9258:NFIB
gene id: 9258:NFIB
uniprot id: F7FDN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9258:ORNANAV1R3094
gene id: 9258:ORNANAV1R3094
uniprot id: F6YV37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TBPL1
gene id: 9258:TBPL1
uniprot id: F6UVN1
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9258:CNEP1R1
gene id: 9258:CNEP1R1
uniprot id: F7F4C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9258:SLC10A7
gene id: 9258:SLC10A7
uniprot id: A0A6I8NM03
uniprot id: F7C2N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9258:B3GALT2
gene id: 9258:B3GALT2
uniprot id: F6V488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9258:ORNANAV1R3112
gene id: 9258:ORNANAV1R3112
uniprot id: A0A6I8P1R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:SCG2
gene id: 9258:SCG2
uniprot id: F7ETF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Interacts with Secretogranin III/SCG3.
messages: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
messages: Secreted

9258:MAPK13
gene id: 9258:MAPK13
uniprot id: F6ZRF3
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

9258:ORNANAV1R3159
gene id: 9258:ORNANAV1R3159
uniprot id: F7APT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:RPL22
gene id: 9258:RPL22
uniprot id: A0A6I8PB14
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9258:CDC37L1
gene id: 9258:CDC37L1
uniprot id: F7DC58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9258:SULT1A
gene id: 9258:SULT1A
uniprot id: Q95JC5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9258:AIDA
gene id: 9258:AIDA
uniprot id: F7G8E0
names: Similarity
messages: Belongs to the AIDA family.

9258:LOC103166461
gene id: 9258:LOC103166461
uniprot id: P0C8A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Has antimicrobial activity.
messages: Highly expressed in kidney, lowly expressed in spleen, and expressed at lower levels in lung.
messages: Secreted

9258:NME2
gene id: 9258:NME2
uniprot id: F6TWB2
names: Similarity
messages: Belongs to the NDK family.

9258:WNT2
gene id: 9258:WNT2
uniprot id: Q07DZ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

9258:BMP7
gene id: 9258:BMP7
uniprot id: F7EZU0
names: Similarity
messages: Belongs to the TGF-beta family.

9258:IFN5
gene id: 9258:IFN5
uniprot id: A8E6E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9258:POLR2F
gene id: 9258:POLR2F
uniprot id: A0A6I8P5I5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9258:BAG6
gene id: 9258:BAG6
uniprot id: A7X5R6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides an…
messages: Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol. Interacts with UBL4A; the interaction is direct and required for UBL4A protein stability. Interacts with AIFM1. Interacts with HSPA2. Interacts with CTCFL. Interacts with p300/EP300. Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation. Interacts with ricin A chain. Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex. Interacts with SYVN1. Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination. Interacts with ZFAND2B. Interacts with KPNA2. Interacts with UBQLN4 (By similarity).
messages: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2).
messages: May mediate ricin-induced apoptosis.
messages: Nucleus
messages: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
messages: Ricin can induce the cleavage by the caspase CASP3.
messages: The ubiquitin-like domain mediates interaction with the E3 ubiquitin-protein ligase RNF126 which is responsible for the BAG6-dependent ubiquitination of client proteins. SGTA also binds this domain and competes with RNF126 to antagonize client protein ubiquitination and degradation. The ubiquitin-like domain also mediates the interaction with USP13.
messages: cytosol
messages: extracellular exosome

9258:FAM219B
gene id: 9258:FAM219B
uniprot id: A0A6I8NGV1
names: Similarity
messages: Belongs to the FAM219 family.

9258:LOC100086581
gene id: 9258:LOC100086581
uniprot id: A0A6I8PG98
names: Subcellular Location Annotation
messages: Nucleus

9258:CFAP206
gene id: 9258:CFAP206
uniprot id: A0A6I8PHN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme

9258:CSE1L
gene id: 9258:CSE1L
uniprot id: F6XDL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9258:RPSA
gene id: 9258:RPSA
uniprot id: F7EXW2
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9258:GALNT5
gene id: 9258:GALNT5
uniprot id: F6WTJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9258:LOC100093239
gene id: 9258:LOC100093239
uniprot id: A0A6I8N7N1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:KATNAL2
gene id: 9258:KATNAL2
uniprot id: F7DX12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

9258:KEF28 p02
gene id: 9258:KEF28_p02
uniprot id: Q36460
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9258:PABPC4
gene id: 9258:PABPC4
uniprot id: F6ZQ23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9258:CPM
gene id: 9258:CPM
uniprot id: F7CJD4
names: Similarity
messages: Belongs to the peptidase M14 family.

9258:GPR142
gene id: 9258:GPR142
uniprot id: F7B822
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9258:DUSP7
gene id: 9258:DUSP7
uniprot id: A0A6I8NDY0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9258:RPL13
gene id: 9258:RPL13
uniprot id: F6Q2G5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

9258:GRHL1
gene id: 9258:GRHL1
uniprot id: A0A6I8MY05
names: Subcellular Location Annotation
messages: Nucleus

9258:LOC100077204
gene id: 9258:LOC100077204
uniprot id: F7D6K9
names: Similarity
messages: Belongs to the BicD family.

9258:PSMA4
gene id: 9258:PSMA4
uniprot id: F6Z866
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9258:STX17
gene id: 9258:STX17
uniprot id: A0A6I8NGJ5
uniprot id: A0A6I8NJC5
names: Similarity
messages: Belongs to the syntaxin family.

9258:MYOC
gene id: 9258:MYOC
uniprot id: F6RC11
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:PPIE
gene id: 9258:PPIE
uniprot id: A0A6I8N7N7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

9258:POU5F1
gene id: 9258:POU5F1
uniprot id: A7X5W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9258:BAMBI
gene id: 9258:BAMBI
uniprot id: F6QKK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9258:ORNANAV1R3047
gene id: 9258:ORNANAV1R3047
uniprot id: A0A6I8NWT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:POGLUT2
gene id: 9258:POGLUT2
uniprot id: F7CT27
names: Similarity
messages: Belongs to the KDELC family.

9258:GNG2
gene id: 9258:GNG2
uniprot id: F6VPY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9258:ORNANAV1R3174
gene id: 9258:ORNANAV1R3174
uniprot id: A0A6I8NEW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100077596
gene id: 9258:LOC100077596
uniprot id: F6VER0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9258:MTMR2
gene id: 9258:MTMR2
uniprot id: F7A9U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9258:ORNANAV1R3267
gene id: 9258:ORNANAV1R3267
uniprot id: A0A6I8P3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100076538
gene id: 9258:LOC100076538
uniprot id: F7GA33
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9258:SLC25A25
gene id: 9258:SLC25A25
uniprot id: A0A6I8MX71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9258:SUSD4
gene id: 9258:SUSD4
uniprot id: F7G838
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:LOC100680750
gene id: 9258:LOC100680750
uniprot id: F7DNX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:KCNS1
gene id: 9258:KCNS1
uniprot id: A0A6I8NK09
names: Subcellular Location Annotation
messages: Membrane

9258:TMCO3
gene id: 9258:TMCO3
uniprot id: F7G4E2
names: Subcellular Location Annotation
messages: Membrane

9258:B2M
gene id: 9258:B2M
uniprot id: Q864T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

9258:LOC103169098
gene id: 9258:LOC103169098
uniprot id: A0A6I8PF74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:CAMK1
gene id: 9258:CAMK1
uniprot id: F7FPX0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9258:SEC23A
gene id: 9258:SEC23A
uniprot id: F6SYZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9258:RAD23A
gene id: 9258:RAD23A
uniprot id: A0A6I8N6B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9258:ST7
gene id: 9258:ST7
uniprot id: Q07DZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9258:SV2B
gene id: 9258:SV2B
uniprot id: A0A6I8NPQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9258:GRIA1
gene id: 9258:GRIA1
uniprot id: A0A6I8NS08
uniprot id: F6YAX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9258:CAPN2
gene id: 9258:CAPN2
uniprot id: F7F9H3
names: Similarity
messages: Belongs to the peptidase C2 family.

9258:SGCA
gene id: 9258:SGCA
uniprot id: F6UNV1
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

9258:ORNANAV1R3098
gene id: 9258:ORNANAV1R3098
uniprot id: F6Z285
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TUBA1B
gene id: 9258:TUBA1B
uniprot id: A0A6I8P882
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9258:INSL3
gene id: 9258:INSL3
uniprot id: B1AAP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9258:ORNANAV1R3238
gene id: 9258:ORNANAV1R3238
uniprot id: F7GDH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:RHO
gene id: 9258:RHO
uniprot id: A4ZIS8
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane

9258:ORNANAV1R3212
gene id: 9258:ORNANAV1R3212
uniprot id: A0A6I8N5V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100093330
gene id: 9258:LOC100093330
uniprot id: A0A6I8PF82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:TBCC
gene id: 9258:TBCC
uniprot id: A0A6I8NH03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9258:GPR83
gene id: 9258:GPR83
uniprot id: A0A6I8PLQ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9258:LOC103171054
gene id: 9258:LOC103171054
uniprot id: F7F050
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9258:PIAS1
gene id: 9258:PIAS1
uniprot id: F7DN97
names: Similarity
messages: Belongs to the PIAS family.

9258:LOC100089376
gene id: 9258:LOC100089376
uniprot id: F7DNX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LOC100089746
gene id: 9258:LOC100089746
uniprot id: F6Q8L3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9258:RAP2C
gene id: 9258:RAP2C
uniprot id: F7A1D4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9258:KCNJ6
gene id: 9258:KCNJ6
uniprot id: F6WIC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9258:ARPC4
gene id: 9258:ARPC4
uniprot id: F7FPY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9258:LOC100093150
gene id: 9258:LOC100093150
uniprot id: F7DNX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:MEIG1
gene id: 9258:MEIG1
uniprot id: F6VDQ6
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9258:RPL23
gene id: 9258:RPL23
uniprot id: A0A6I8PG80
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.

9258:LOC103168452
gene id: 9258:LOC103168452
uniprot id: A0A6I8NPI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9258:CNOT8
gene id: 9258:CNOT8
uniprot id: F6Z3Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9258:MCHR2
gene id: 9258:MCHR2
uniprot id: F7GE53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:MED4
gene id: 9258:MED4
uniprot id: A0A6I8N6V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9258:SH3BP4
gene id: 9258:SH3BP4
uniprot id: F7DJ60
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9258:SDE2
gene id: 9258:SDE2
uniprot id: F7F1N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

9258:LOC100093220
gene id: 9258:LOC100093220
uniprot id: A0A6I8N7N1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LOC100083813
gene id: 9258:LOC100083813
uniprot id: F6XEV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:RPS27L
gene id: 9258:RPS27L
uniprot id: A0A6I8NPD9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9258:PTP4A2
gene id: 9258:PTP4A2
uniprot id: F7FFX5
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9258:ORNANAV1R3107
gene id: 9258:ORNANAV1R3107
uniprot id: F7G9L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:CCNJ
gene id: 9258:CCNJ
uniprot id: A0A6I8NFI9
names: Similarity
messages: Belongs to the cyclin family.

9258:ID2
gene id: 9258:ID2
uniprot id: F7FSY1
names: Subcellular Location Annotation
messages: Nucleus

9258:STC1
gene id: 9258:STC1
uniprot id: F7EP00
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9258:PSKH1
gene id: 9258:PSKH1
uniprot id: F6VN36
names: Similarity
messages: Belongs to the protein kinase superfamily.

9258:RPS17
gene id: 9258:RPS17
uniprot id: F7DYA2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9258:LOC100077243
gene id: 9258:LOC100077243
uniprot id: F7B2V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9258:EMC3
gene id: 9258:EMC3
uniprot id: F7DLA1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9258:CASK
gene id: 9258:CASK
uniprot id: A0A6I8N2K3
names: Similarity
messages: Belongs to the MAGUK family.

9258:WSCD1
gene id: 9258:WSCD1
uniprot id: F7FLJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Golgi apparatus membrane
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9258:ALDH2
gene id: 9258:ALDH2
uniprot id: F7FFC7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9258:SOAT1
gene id: 9258:SOAT1
uniprot id: A0A6I8NKQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:ORNANAV1R3141
gene id: 9258:ORNANAV1R3141
uniprot id: A0A6I8MZM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:MID1
gene id: 9258:MID1
uniprot id: F6SKR8
names: Subcellular Location Annotation
messages: cytoskeleton

9258:LOC103164844
gene id: 9258:LOC103164844
uniprot id: A0A6I8PBW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9258:TM4SF20
gene id: 9258:TM4SF20
uniprot id: F6U9U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9258:TIMM10
gene id: 9258:TIMM10
uniprot id: F6T7K0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9258:GPR146
gene id: 9258:GPR146
uniprot id: F6V2S4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9258:ZNF330
gene id: 9258:ZNF330
uniprot id: F7BM32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: centromere
messages: nucleolus

9258:SPP2
gene id: 9258:SPP2
uniprot id: A0A6I8NPJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Secreted

9258:PRICKLE1
gene id: 9258:PRICKLE1
uniprot id: F6U3C0
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9258:LOC100093353
gene id: 9258:LOC100093353
uniprot id: A0A6I8N139
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LOC100091379
gene id: 9258:LOC100091379
uniprot id: F6W205
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9258:MPPED2
gene id: 9258:MPPED2
uniprot id: K7EFC2
names: Similarity
messages: Belongs to the UPF0046 family.

9258:PPIF
gene id: 9258:PPIF
uniprot id: F6R1C3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9258:PPIL1
gene id: 9258:PPIL1
uniprot id: A0A6I8PCF1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9258:MRPL15
gene id: 9258:MRPL15
uniprot id: F6YQL1
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9258:LOC100083090
gene id: 9258:LOC100083090
uniprot id: F6XEE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:STN1
gene id: 9258:STN1
uniprot id: A0A6I8NMI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9258:UBA52
gene id: 9258:UBA52
uniprot id: F6SCZ0
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

9258:EPC1
gene id: 9258:EPC1
uniprot id: A0A6I8PDR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9258:KEF28 p07
gene id: 9258:KEF28_p07
uniprot id: Q36455
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9258:RAD1
gene id: 9258:RAD1
uniprot id: F6UI60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9258:ORNANAV1R3093
gene id: 9258:ORNANAV1R3093
uniprot id: F7G2A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:DCLRE1C
gene id: 9258:DCLRE1C
uniprot id: F6VDP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9258:TBL1X
gene id: 9258:TBL1X
uniprot id: F6S036
names: Similarity
messages: Belongs to the WD repeat EBI family.

9258:OPN1SW2
gene id: 9258:OPN1SW2
uniprot id: A4ZIS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9258:HOXA9
gene id: 9258:HOXA9
uniprot id: A0A6I8MXB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9258:LOC100076644
gene id: 9258:LOC100076644
uniprot id: F6TGI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9258:LOC100092493
gene id: 9258:LOC100092493
uniprot id: F6QWB7
names: Similarity
messages: Belongs to the actin family.

9258:EOGT
gene id: 9258:EOGT
uniprot id: A0A6I8P2Z7
uniprot id: F7ENU8
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9258:SLC9A4
gene id: 9258:SLC9A4
uniprot id: A0A6I8P858
uniprot id: F7F984
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9258:ROPN1L
gene id: 9258:ROPN1L
uniprot id: F6YIJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: flagellum

9258:LOC100093210
gene id: 9258:LOC100093210
uniprot id: F6PX78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:ORNANAV1R3128
gene id: 9258:ORNANAV1R3128
uniprot id: A0A6I8N7K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:KIF1A
gene id: 9258:KIF1A
uniprot id: A0A6I8P315
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

9258:GPR137B
gene id: 9258:GPR137B
uniprot id: A0A6I8N6Z9
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9258:KPNA3
gene id: 9258:KPNA3
uniprot id: F6W5W7
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9258:LOC100075061
gene id: 9258:LOC100075061
uniprot id: F6PYG8
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9258:NGDN
gene id: 9258:NGDN
uniprot id: F7A2Y0
names: Subcellular Location Annotation
messages: nucleolus

9258:KEF28 p11
gene id: 9258:KEF28_p11
uniprot id: Q36452
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9258:LPL
gene id: 9258:LPL
uniprot id: F7CIW2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9258:LOC100079889
gene id: 9258:LOC100079889
uniprot id: F6TZI4
names: Similarity
messages: Belongs to the IAP family.

9258:REXO2
gene id: 9258:REXO2
uniprot id: F7EJ45
names: Similarity
messages: Belongs to the oligoribonuclease family.

9258:ORNANAV1R3123
gene id: 9258:ORNANAV1R3123
uniprot id: F6VH07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:VGLL4
gene id: 9258:VGLL4
uniprot id: A0A6I8NY28
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9258:TRARG1
gene id: 9258:TRARG1
uniprot id: A0A6I8NCK9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9258:FAM20C
gene id: 9258:FAM20C
uniprot id: F7CXH9
names: Similarity
messages: Belongs to the FAM20 family.

9258:LOC100089121
gene id: 9258:LOC100089121
uniprot id: F7FZV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:RPL5
gene id: 9258:RPL5
uniprot id: F7FG88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9258:HAO1
gene id: 9258:HAO1
uniprot id: F6VW26
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9258:LOC100093204
gene id: 9258:LOC100093204
uniprot id: A0A6I8P814
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:TMEM45A
gene id: 9258:TMEM45A
uniprot id: A0A6I8P1K5
uniprot id: F7CHV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9258:STARD3NL
gene id: 9258:STARD3NL
uniprot id: F6XTA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Membrane

9258:ORNANAV1R3108
gene id: 9258:ORNANAV1R3108
uniprot id: F6W5I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:OTC
gene id: 9258:OTC
uniprot id: A0A6I8PCR4
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

9258:SNTG1
gene id: 9258:SNTG1
uniprot id: F7CKJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9258:ORNANAV1R3234
gene id: 9258:ORNANAV1R3234
uniprot id: A0A6I8NP31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100093163
gene id: 9258:LOC100093163
uniprot id: A0A6I8N139
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:YPEL4
gene id: 9258:YPEL4
uniprot id: F7E6Q4
names: Similarity
messages: Belongs to the yippee family.

9258:ACSL6
gene id: 9258:ACSL6
uniprot id: A0A6I8N2T7
uniprot id: F7G6L5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

9258:LOC100076650
gene id: 9258:LOC100076650
uniprot id: F7E1J1
names: Similarity
messages: Belongs to the thioredoxin family.

9258:CWF19L1
gene id: 9258:CWF19L1
uniprot id: F6WA07
names: Similarity
messages: Belongs to the CWF19 family.

9258:CD82
gene id: 9258:CD82
uniprot id: A0A6I8P193
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9258:TAT
gene id: 9258:TAT
uniprot id: F6RG81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9258:PNRC2
gene id: 9258:PNRC2
uniprot id: A0A6I8NS77
names: Subcellular Location Annotation
messages: Nucleus

9258:ARL5A
gene id: 9258:ARL5A
uniprot id: A0A6I8P6M5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9258:CHN2
gene id: 9258:CHN2
uniprot id: F7D0R2
names: Function
messages: GTPase-activating protein for p21-rac.

9258:C2H12orf43
gene id: 9258:C2H12orf43
uniprot id: F7DT61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

9258:STARD13
gene id: 9258:STARD13
uniprot id: F7B8Q1
names: Subcellular Location Annotation
messages: Cytoplasm

9258:RCAN2
gene id: 9258:RCAN2
uniprot id: A0A6I8N6N8
uniprot id: A0A6I8NCE8
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9258:PPARGC1A
gene id: 9258:PPARGC1A
uniprot id: A0A6I8NSB1
names: Subcellular Location Annotation
messages: PML body

9258:ATP2B3
gene id: 9258:ATP2B3
uniprot id: F6QI04
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9258:GCNT3
gene id: 9258:GCNT3
uniprot id: F6WVK0
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9258:BTK
gene id: 9258:BTK
uniprot id: F7BKT0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9258:SFXN2
gene id: 9258:SFXN2
uniprot id: F7D0H7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9258:KIN
gene id: 9258:KIN
uniprot id: A0A6I8PH44
names: Similarity
messages: Belongs to the KIN17 family.

9258:TLE4
gene id: 9258:TLE4
uniprot id: A0A6I8PCX9
uniprot id: A0A6I8PH51
uniprot id: F7EFU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9258:LOC100084062
gene id: 9258:LOC100084062
uniprot id: F7C9W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9258:EEF1G
gene id: 9258:EEF1G
uniprot id: A0A6I8NEF9
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9258:LOC100090093
gene id: 9258:LOC100090093
uniprot id: A0A6I8N664
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9258:LOC100078561
gene id: 9258:LOC100078561
uniprot id: K7EES2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9258:LOC100086261
gene id: 9258:LOC100086261
uniprot id: A0A6I8N3G9
names: Subcellular Location Annotation
messages: Membrane

9258:SMPX
gene id: 9258:SMPX
uniprot id: A0A6I8NF39
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

9258:CHEK1
gene id: 9258:CHEK1
uniprot id: A0A6I8NUW9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9258:YTHDF1
gene id: 9258:YTHDF1
uniprot id: F7DG05
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9258:SLC9A2
gene id: 9258:SLC9A2
uniprot id: F7F968
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9258:TPH1
gene id: 9258:TPH1
uniprot id: A0A6I8NSJ5
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9258:MYMK
gene id: 9258:MYMK
uniprot id: A0A6I8MZV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9258:CDC26
gene id: 9258:CDC26
uniprot id: F7ALV7
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9258:PSMB11
gene id: 9258:PSMB11
uniprot id: F7ECE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9258:LOC100078585
gene id: 9258:LOC100078585
uniprot id: A7X5N3
names: Similarity
messages: Belongs to the MHC class I family.

9258:COPS5
gene id: 9258:COPS5
uniprot id: A0A6I8NTU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9258:B4GAT1
gene id: 9258:B4GAT1
uniprot id: F7E7G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9258:ORNANAV1R3236
gene id: 9258:ORNANAV1R3236
uniprot id: A0A6I8NV00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:NLGN4X
gene id: 9258:NLGN4X
uniprot id: A0A6I8PQR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9258:ORNANAV1R3014
gene id: 9258:ORNANAV1R3014
uniprot id: A0A6I8P899
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:AP1G1
gene id: 9258:AP1G1
uniprot id: A0A6I8PI71
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9258:CACNB4
gene id: 9258:CACNB4
uniprot id: A0A6I8N9C0
uniprot id: A0A6I8P1X2
uniprot id: B6IDG4
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9258:TMEM182
gene id: 9258:TMEM182
uniprot id: F7F954
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9258:ORNANAV1R3008
gene id: 9258:ORNANAV1R3008
uniprot id: F7BJD9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9258:LDHA
gene id: 9258:LDHA
uniprot id: Q7YQK6
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9258:TMEM11
gene id: 9258:TMEM11
uniprot id: F6PX52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Plays a role in mitochondrial morphogenesis.

9258:ENO1
gene id: 9258:ENO1
uniprot id: F7FAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9258:CLDN5
gene id: 9258:CLDN5
uniprot id: F7DGF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9258:SPON2
gene id: 9258:SPON2
uniprot id: F6YV63
names: Subcellular Location Annotation
messages: extracellular matrix

9258:LOC100079040
gene id: 9258:LOC100079040
uniprot id: F7FFR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9258:GRB10
gene id: 9258:GRB10
uniprot id: A0A6I8NX22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9258:ORNANAV1R3188
gene id: 9258:ORNANAV1R3188
uniprot id: A0A6I8MX55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TFAP2D
gene id: 9258:TFAP2D
uniprot id: F6U400
names: Similarity
messages: Belongs to the AP-2 family.

9258:C20H11orf54
gene id: 9258:C20H11orf54
uniprot id: F6Z8K9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9258:DDIT4
gene id: 9258:DDIT4
uniprot id: A0A6I8P6W6
names: Similarity
messages: Belongs to the DDIT4 family.

9258:LOC100083958
gene id: 9258:LOC100083958
uniprot id: F7FYV4
names: Subcellular Location Annotation
messages: Membrane

9258:EML6
gene id: 9258:EML6
uniprot id: F7FJT4
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

9258:LOC100089146
gene id: 9258:LOC100089146
uniprot id: F7CP40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100079368
gene id: 9258:LOC100079368
uniprot id: F7G768
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TPR
gene id: 9258:TPR
uniprot id: F6R964
names: Similarity
messages: Belongs to the TPR family.

9258:RTRAF
gene id: 9258:RTRAF
uniprot id: F6VQ29
names: Similarity
messages: Belongs to the RTRAF family.

9258:ACVR1C
gene id: 9258:ACVR1C
uniprot id: F6W004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9258:MRPS14
gene id: 9258:MRPS14
uniprot id: A0A6I8N1W2
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9258:LOC100093356
gene id: 9258:LOC100093356
uniprot id: A0A6I8N139
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LOC100093566
gene id: 9258:LOC100093566
uniprot id: A0A6I8N2P1
names: Subcellular Location Annotation
messages: Membrane

9258:LOC100082027
gene id: 9258:LOC100082027
uniprot id: A0A6I8NM90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100093192
gene id: 9258:LOC100093192
uniprot id: F6PX78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:ORNANAV1R3030
gene id: 9258:ORNANAV1R3030
uniprot id: F6TCZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:ORNANAV1R3064
gene id: 9258:ORNANAV1R3064
uniprot id: A0A6I8MZS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100080278
gene id: 9258:LOC100080278
uniprot id: F6VNE8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9258:LOC100075293
gene id: 9258:LOC100075293
uniprot id: F7F399
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

9258:IP6K2
gene id: 9258:IP6K2
uniprot id: F7FEM8
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9258:SLC30A2
gene id: 9258:SLC30A2
uniprot id: F6W472
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9258:GET1
gene id: 9258:GET1
uniprot id: A0A6I8PHA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:DHRS9
gene id: 9258:DHRS9
uniprot id: F6WND2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9258:RTCB
gene id: 9258:RTCB
uniprot id: F6X5L9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9258:SPG21
gene id: 9258:SPG21
uniprot id: A0A6I8NIT6
names: Function
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9258:XKR9
gene id: 9258:XKR9
uniprot id: F7FT32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9258:MEAF6
gene id: 9258:MEAF6
uniprot id: A0A6I8NBF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

9258:LOC100093232
gene id: 9258:LOC100093232
uniprot id: F6PX78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:IFN1
gene id: 9258:IFN1
uniprot id: A8E6D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9258:FGF6
gene id: 9258:FGF6
uniprot id: F7D173
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9258:ESRRG
gene id: 9258:ESRRG
uniprot id: A0A6I8NQJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9258:TSNAX
gene id: 9258:TSNAX
uniprot id: F7FPM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9258:RRS1
gene id: 9258:RRS1
uniprot id: F7FNC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9258:RUNX1T1
gene id: 9258:RUNX1T1
uniprot id: A0A6I8N432
uniprot id: A0A6I8NR78
uniprot id: A0A6I8PEU4
names: Similarity
messages: Belongs to the CBFA2T family.

9258:GABRB2
gene id: 9258:GABRB2
uniprot id: A0A6I8NZY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9258:LOC100076093
gene id: 9258:LOC100076093
uniprot id: F6QKJ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9258:LOC100079414
gene id: 9258:LOC100079414
uniprot id: A0A6I8PJK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:CHN1
gene id: 9258:CHN1
uniprot id: F6XIY5
names: Function
messages: GTPase-activating protein for p21-rac.

9258:AP3M2
gene id: 9258:AP3M2
uniprot id: F6ZDY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9258:EEF1A2
gene id: 9258:EEF1A2
uniprot id: A0A6I8N4L0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9258:MMP2
gene id: 9258:MMP2
uniprot id: F7FCH2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

9258:NME5
gene id: 9258:NME5
uniprot id: F7FRU9
names: Similarity
messages: Belongs to the NDK family.

9258:THNSL2
gene id: 9258:THNSL2
uniprot id: F7B3V8
names: Similarity
messages: Belongs to the threonine synthase family.

9258:CPSF2
gene id: 9258:CPSF2
uniprot id: F6T6L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9258:SLC5A12
gene id: 9258:SLC5A12
uniprot id: A0A6I8MYF8
uniprot id: F6T2V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9258:LOC100076942
gene id: 9258:LOC100076942
uniprot id: A0A6I8N139
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:GAS8
gene id: 9258:GAS8
uniprot id: F6TMR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum
messages: flagellum axoneme

9258:TFCP2L1
gene id: 9258:TFCP2L1
uniprot id: A0A6I8PIQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9258:MINAR1
gene id: 9258:MINAR1
uniprot id: F6THE0
names: Similarity
messages: Belongs to the MINAR family.

9258:TMEM35B
gene id: 9258:TMEM35B
uniprot id: A0A6I8PA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9258:LOC100074485
gene id: 9258:LOC100074485
uniprot id: F7DUU6
names: Similarity
messages: Belongs to the intermediate filament family.

9258:EIF2S1
gene id: 9258:EIF2S1
uniprot id: A0A6I8PJL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9258:FBXO9
gene id: 9258:FBXO9
uniprot id: F6TN74
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9258:TLCD3B
gene id: 9258:TLCD3B
uniprot id: F7DGF1
names: Subcellular Location Annotation
messages: Membrane

9258:KLC1
gene id: 9258:KLC1
uniprot id: A0A6I8PCS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9258:ORNANAV1R3255
gene id: 9258:ORNANAV1R3255
uniprot id: A0A6I8N2C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TEX28
gene id: 9258:TEX28
uniprot id: A0A6I8NVN0
names: Similarity
messages: Belongs to the TEX28 family.

9258:LOC103166906
gene id: 9258:LOC103166906
uniprot id: K7EAI7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

9258:EPHA3
gene id: 9258:EPHA3
uniprot id: F7EX10
names: Subcellular Location Annotation
messages: Membrane

9258:LOC100086273
gene id: 9258:LOC100086273
uniprot id: F6PSG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:CLIC2
gene id: 9258:CLIC2
uniprot id: A0A6I8PSZ6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9258:INTS7
gene id: 9258:INTS7
uniprot id: F7BQ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9258:LOC100093382
gene id: 9258:LOC100093382
uniprot id: A0A6I8N139
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LOC100083161
gene id: 9258:LOC100083161
uniprot id: F7GA89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:DUSP10
gene id: 9258:DUSP10
uniprot id: F7GDU1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9258:LOC100680868
gene id: 9258:LOC100680868
uniprot id: A0A6I8P5R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100075884
gene id: 9258:LOC100075884
uniprot id: A0A6I8PG89
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9258:FGF13
gene id: 9258:FGF13
uniprot id: A0A6I8MXC5
uniprot id: A0A6I8N286
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9258:SLC1A2
gene id: 9258:SLC1A2
uniprot id: F6PQH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9258:SRP19
gene id: 9258:SRP19
uniprot id: A0A6I8NW72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9258:LOC100682172
gene id: 9258:LOC100682172
uniprot id: F7GAE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TM4SF4
gene id: 9258:TM4SF4
uniprot id: F7F7Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9258:LOC100084723
gene id: 9258:LOC100084723
uniprot id: F7EN88
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9258:YPEL5
gene id: 9258:YPEL5
uniprot id: A0A6I8NB31
names: Similarity
messages: Belongs to the yippee family.

9258:BRCC3
gene id: 9258:BRCC3
uniprot id: F7C9Y2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9258:MASP1
gene id: 9258:MASP1
uniprot id: A0A6I8PKP3
uniprot id: F6XMS5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9258:FIBIN
gene id: 9258:FIBIN
uniprot id: A0A6I8N9D7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9258:SLC25A15
gene id: 9258:SLC25A15
uniprot id: A0A6I8PFJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9258:LOC100089603
gene id: 9258:LOC100089603
uniprot id: F7GC54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9258:NPPA
gene id: 9258:NPPA
uniprot id: F6TF44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9258:DGKE
gene id: 9258:DGKE
uniprot id: F6TEN0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9258:GDNF
gene id: 9258:GDNF
uniprot id: F6X835
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9258:ELOF1
gene id: 9258:ELOF1
uniprot id: F7C8K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9258:LOC100083206
gene id: 9258:LOC100083206
uniprot id: F6X7U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9258:ORNANAV1R3249
gene id: 9258:ORNANAV1R3249
uniprot id: A0A6I8NZ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:RAB14
gene id: 9258:RAB14
uniprot id: A0A6I8NCW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9258:BDKRB1
gene id: 9258:BDKRB1
uniprot id: F6R303
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9258:SEC61A1
gene id: 9258:SEC61A1
uniprot id: F7G1S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:CDK20
gene id: 9258:CDK20
uniprot id: F6Y2P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: cilium

9258:ORNANAV1R3049
gene id: 9258:ORNANAV1R3049
uniprot id: F7CML3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:RPS19
gene id: 9258:RPS19
uniprot id: F7DVV4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

9258:LAP3
gene id: 9258:LAP3
uniprot id: F6XA92
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9258:KDM4A
gene id: 9258:KDM4A
uniprot id: F6XDU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9258:EMX2
gene id: 9258:EMX2
uniprot id: A0A6I8PAK7
names: Subcellular Location Annotation
messages: Nucleus

9258:SLC46A2
gene id: 9258:SLC46A2
uniprot id: F6YJB3
names: Subcellular Location Annotation
messages: Membrane

9258:MYF6
gene id: 9258:MYF6
uniprot id: F7DJU2
names: Subcellular Location Annotation
messages: Nucleus

9258:GPR34
gene id: 9258:GPR34
uniprot id: F7DPA1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9258:CAPZA2
gene id: 9258:CAPZA2
uniprot id: Q07E00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity).

9258:IFT57
gene id: 9258:IFT57
uniprot id: F6QKV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9258:LOC100093365
gene id: 9258:LOC100093365
uniprot id: A0A6I8NTJ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:EXOSC2
gene id: 9258:EXOSC2
uniprot id: F6QCI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9258:MPP7
gene id: 9258:MPP7
uniprot id: A0A6I8P3S5
uniprot id: F6QL81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9258:ACBD5
gene id: 9258:ACBD5
uniprot id: F6QLI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

9258:HMGB3
gene id: 9258:HMGB3
uniprot id: A0A6I8P7X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9258:STAR
gene id: 9258:STAR
uniprot id: F6UVJ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

9258:LOC100081236
gene id: 9258:LOC100081236
uniprot id: A0A6I8PNY6
names: Similarity
messages: Belongs to the SEC2 family.

9258:NR0B2
gene id: 9258:NR0B2
uniprot id: K7E9L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9258:LOC100090698
gene id: 9258:LOC100090698
uniprot id: A0A6I8PF82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:FASLG
gene id: 9258:FASLG
uniprot id: F6RBI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9258:HAL
gene id: 9258:HAL
uniprot id: F6Q611
names: Similarity
messages: Belongs to the PAL/histidase family.

9258:IER2
gene id: 9258:IER2
uniprot id: A0A6I8N3B6
names: Similarity
messages: Belongs to the IER family.

9258:LOC100093142
gene id: 9258:LOC100093142
uniprot id: F7DNX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LOC100082886
gene id: 9258:LOC100082886
uniprot id: F7GAK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:CCN1
gene id: 9258:CCN1
uniprot id: F7F191
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9258:LOC100087385
gene id: 9258:LOC100087385
uniprot id: F7FHT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TPRG1
gene id: 9258:TPRG1
uniprot id: F7DUR8
names: Similarity
messages: Belongs to the TPRG1 family.

9258:NR1H4
gene id: 9258:NR1H4
uniprot id: F6PYB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9258:RAB18
gene id: 9258:RAB18
uniprot id: A0A6I8P127
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9258:CTBP1
gene id: 9258:CTBP1
uniprot id: F6YV22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9258:EXOC2
gene id: 9258:EXOC2
uniprot id: F6R680
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9258:HNRNPK
gene id: 9258:HNRNPK
uniprot id: F7EHL0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9258:LOC100074778
gene id: 9258:LOC100074778
uniprot id: F7E0A6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9258:ACKR3
gene id: 9258:ACKR3
uniprot id: F7AW12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100084402
gene id: 9258:LOC100084402
uniprot id: F6VVV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Membrane
messages: Microsome membrane

9258:RRM1
gene id: 9258:RRM1
uniprot id: F6U4A0
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9258:ORNANAV1R3105
gene id: 9258:ORNANAV1R3105
uniprot id: A0A6I8NX09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:SSTR3
gene id: 9258:SSTR3
uniprot id: F7FHB0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9258:KIF5B
gene id: 9258:KIF5B
uniprot id: F6PPG1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9258:GLUL
gene id: 9258:GLUL
uniprot id: A0A6I8PF24
names: Similarity
messages: Belongs to the glutamine synthetase family.

9258:LPIN2
gene id: 9258:LPIN2
uniprot id: F7EDH5
names: Similarity
messages: Belongs to the lipin family.

9258:THEMIS2
gene id: 9258:THEMIS2
uniprot id: F6T5T5
names: Similarity
messages: Belongs to the themis family.

9258:ORNANAV1R3254
gene id: 9258:ORNANAV1R3254
uniprot id: A0A6I8NKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:ALG5
gene id: 9258:ALG5
uniprot id: F6Y0V8
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9258:F9
gene id: 9258:F9
uniprot id: F6S689
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9258:ORNANAV1R3003
gene id: 9258:ORNANAV1R3003
uniprot id: A0A6I8N0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:ARL6IP5
gene id: 9258:ARL6IP5
uniprot id: F7EX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9258:S100Z
gene id: 9258:S100Z
uniprot id: F7G3H7
names: Similarity
messages: Belongs to the S-100 family.

9258:LOC100080892
gene id: 9258:LOC100080892
uniprot id: F6ZYI9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

9258:SETDB2
gene id: 9258:SETDB2
uniprot id: F6W5R9
names: Subcellular Location Annotation
messages: Chromosome

9258:PDCD11
gene id: 9258:PDCD11
uniprot id: F7DAV0
names: Subcellular Location Annotation
messages: nucleolus

9258:PHLDA3
gene id: 9258:PHLDA3
uniprot id: F7G6A0
names: Subcellular Location Annotation
messages: Cytoplasm

9258:CEP20
gene id: 9258:CEP20
uniprot id: F6WGN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9258:LOC100074423
gene id: 9258:LOC100074423
uniprot id: A0A6I8NUD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100090733
gene id: 9258:LOC100090733
uniprot id: A0A6I8NGX5
names: Subcellular Location Annotation
messages: Membrane

9258:FAM110C
gene id: 9258:FAM110C
uniprot id: A0A6I8NBB3
names: Similarity
messages: Belongs to the FAM110 family.

9258:PSMA7
gene id: 9258:PSMA7
uniprot id: F6VA36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9258:ORNANAV1R3160
gene id: 9258:ORNANAV1R3160
uniprot id: F7F387
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100085082
gene id: 9258:LOC100085082
uniprot id: A0A6I8P3U1
names: Subcellular Location Annotation
messages: Nucleus

9258:KEF28 p05
gene id: 9258:KEF28_p05
uniprot id: Q36457
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Mitochondrion inner membrane

9258:NME7
gene id: 9258:NME7
uniprot id: A0A6I8N5N1
uniprot id: F6YIW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9258:NR2C1
gene id: 9258:NR2C1
uniprot id: F6Q511
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9258:PHTF2
gene id: 9258:PHTF2
uniprot id: F6PRC2
names: Subcellular Location Annotation
messages: Membrane

9258:RPS25
gene id: 9258:RPS25
uniprot id: F6SC43
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the small ribosomal subunit.

9258:NUDT3
gene id: 9258:NUDT3
uniprot id: F6W8P7
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9258:DTWD2
gene id: 9258:DTWD2
uniprot id: A0A6I8NPA2
names: Similarity
messages: Belongs to the TDD superfamily. DTWD2 family.

9258:LOC100081672
gene id: 9258:LOC100081672
uniprot id: F7ET78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9258:ORNANAV1R3007
gene id: 9258:ORNANAV1R3007
uniprot id: F7BJ89
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9258:LOC100682157
gene id: 9258:LOC100682157
uniprot id: F7GAE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:JAG1
gene id: 9258:JAG1
uniprot id: F6VUQ4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9258:CPVL
gene id: 9258:CPVL
uniprot id: A0A6I8NPM2
uniprot id: F7D0S5
names: Similarity
messages: Belongs to the peptidase S10 family.

9258:RMI1
gene id: 9258:RMI1
uniprot id: F6ZMF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9258:NR2C2
gene id: 9258:NR2C2
uniprot id: A0A6I8PFQ4
uniprot id: F7AE27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9258:SPACA4
gene id: 9258:SPACA4
uniprot id: F7A6Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9258:ANAPC4
gene id: 9258:ANAPC4
uniprot id: F6VID4
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

9258:LOC100091117
gene id: 9258:LOC100091117
uniprot id: A0A6I8N3D7
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9258:EDNRA
gene id: 9258:EDNRA
uniprot id: F6VIX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9258:LOC100081512
gene id: 9258:LOC100081512
uniprot id: F7G1E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9258:ORNANAV1R3251
gene id: 9258:ORNANAV1R3251
uniprot id: A0A6I8P703
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:PTK6
gene id: 9258:PTK6
uniprot id: F7FTR4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9258:LOC100074166
gene id: 9258:LOC100074166
uniprot id: A0A6I8NAG4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9258:SKA2
gene id: 9258:SKA2
uniprot id: A0A6I8N2Y4
uniprot id: A0A6I8NB94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

9258:LOC100086552
gene id: 9258:LOC100086552
uniprot id: A0A6I8PMV1
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9258:KCMF1
gene id: 9258:KCMF1
uniprot id: F6PV34
names: Function
names: Similarity
messages: Belongs to the KCMF1 family.
messages: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.

9258:ORNANAV1R3043
gene id: 9258:ORNANAV1R3043
uniprot id: A0A6I8P939
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:ORNANAV1R3262
gene id: 9258:ORNANAV1R3262
uniprot id: A0A6I8PFK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:PENK
gene id: 9258:PENK
uniprot id: F6VPS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9258:TECRL
gene id: 9258:TECRL
uniprot id: F7F004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9258:FGF4
gene id: 9258:FGF4
uniprot id: A0A6I8NM05
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9258:KEF28 p09
gene id: 9258:KEF28_p09
uniprot id: Q36453
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrion membrane

9258:DYNC1H1
gene id: 9258:DYNC1H1
uniprot id: F6X0U8
names: Similarity
messages: Belongs to the dynein heavy chain family.

9258:NMUR2
gene id: 9258:NMUR2
uniprot id: F6YAW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9258:ORNANAV1R3130
gene id: 9258:ORNANAV1R3130
uniprot id: A0A6I8N1I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:MRPL51
gene id: 9258:MRPL51
uniprot id: F6TAG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Mitochondrion

9258:BMP2
gene id: 9258:BMP2
uniprot id: A0A6I8NNW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9258:KDELR2
gene id: 9258:KDELR2
uniprot id: F6RQH9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9258:LOC100075034
gene id: 9258:LOC100075034
uniprot id: F6WRY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

9258:LOC100084187
gene id: 9258:LOC100084187
uniprot id: F7FYL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:GALR1
gene id: 9258:GALR1
uniprot id: A0A6I8NHZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9258:NDC80
gene id: 9258:NDC80
uniprot id: F6QUM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9258:SMU1
gene id: 9258:SMU1
uniprot id: F6Z044
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9258:ST3GAL5
gene id: 9258:ST3GAL5
uniprot id: A0A0F7RQT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9258:GABRA6
gene id: 9258:GABRA6
uniprot id: F7FRW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9258:SCGB1A1
gene id: 9258:SCGB1A1
uniprot id: F6YRI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9258:SCARA5
gene id: 9258:SCARA5
uniprot id: F7EEJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9258:ORNANAV1R3237
gene id: 9258:ORNANAV1R3237
uniprot id: A0A6I8PF73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100093270
gene id: 9258:LOC100093270
uniprot id: A0A6I8N139
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:CEBPG
gene id: 9258:CEBPG
uniprot id: F7EWR3
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

9258:LOC100073518
gene id: 9258:LOC100073518
uniprot id: F7G3K3
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9258:LOC100078687
gene id: 9258:LOC100078687
uniprot id: F7EDX1
names: Subcellular Location Annotation
messages: Nucleus

9258:FSHB
gene id: 9258:FSHB
uniprot id: A0A6I8N0P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9258:FGB
gene id: 9258:FGB
uniprot id: F7CSS4
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9258:MAGOH
gene id: 9258:MAGOH
uniprot id: F6SH35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9258:KEF28 p13
gene id: 9258:KEF28_p13
uniprot id: Q37717
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion inner membrane

9258:HDHD2
gene id: 9258:HDHD2
uniprot id: F7DX02
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9258:LOC100092684
gene id: 9258:LOC100092684
uniprot id: F6U6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9258:CKMT2
gene id: 9258:CKMT2
uniprot id: F7EGQ7
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9258:DDX4
gene id: 9258:DDX4
uniprot id: G0XSV8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9258:ORNANAV1R3250
gene id: 9258:ORNANAV1R3250
uniprot id: A0A6I8PAI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:THNSL1
gene id: 9258:THNSL1
uniprot id: F6V5M8
names: Similarity
messages: Belongs to the threonine synthase family.

9258:CPB2
gene id: 9258:CPB2
uniprot id: F7DZP9
names: Similarity
messages: Belongs to the peptidase M14 family.

9258:F10
gene id: 9258:F10
uniprot id: Q9GMD9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9258:CDH12
gene id: 9258:CDH12
uniprot id: F6VEV5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9258:IL10
gene id: 9258:IL10
uniprot id: A0A6I8N7H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9258:TERT
gene id: 9258:TERT
uniprot id: F2YSU1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
messages: The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity.
messages: The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.
messages: The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.
messages: nucleolus
messages: nucleoplasm
messages: telomere

9258:LPGAT1
gene id: 9258:LPGAT1
uniprot id: F7CCP4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9258:RIOX2
gene id: 9258:RIOX2
uniprot id: F6TJS3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. MINA53 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.

9258:GBGT1
gene id: 9258:GBGT1
uniprot id: A0A6I8N0I6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

9258:CLIC5
gene id: 9258:CLIC5
uniprot id: A0A6I8N5Z3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9258:PROM1
gene id: 9258:PROM1
uniprot id: E9LZ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9258:MSR1
gene id: 9258:MSR1
uniprot id: A0A6I8N6E9
uniprot id: F6WYX0
names: Subcellular Location Annotation
messages: Membrane

9258:PPP3R1
gene id: 9258:PPP3R1
uniprot id: F6XMP0
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9258:TMSB15B
gene id: 9258:TMSB15B
uniprot id: F7BKI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9258:RAB3A
gene id: 9258:RAB3A
uniprot id: F6VQY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9258:TSPAN18
gene id: 9258:TSPAN18
uniprot id: A0A6I8N493
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9258:BABAM2
gene id: 9258:BABAM2
uniprot id: A0A6I8N8U9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9258:LOC100083044
gene id: 9258:LOC100083044
uniprot id: F6Q2J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:CACNG1
gene id: 9258:CACNG1
uniprot id: F7CV23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

9258:POLR3F
gene id: 9258:POLR3F
uniprot id: F6XG18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9258:LOC100083627
gene id: 9258:LOC100083627
uniprot id: A0A6I8PGF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9258:NRG1
gene id: 9258:NRG1
uniprot id: A0A6I8P848
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9258:EXOSC9
gene id: 9258:EXOSC9
uniprot id: A0A6I8NAZ8
names: Subcellular Location Annotation
messages: Cytoplasm

9258:OGG1
gene id: 9258:OGG1
uniprot id: A0A6I8PGM6
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9258:SPA17
gene id: 9258:SPA17
uniprot id: A0A6I8ND67
uniprot id: Q6SJ92
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9258:SLC26A2
gene id: 9258:SLC26A2
uniprot id: A0A6I8N3P3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion.

9258:CMC4
gene id: 9258:CMC4
uniprot id: F7C9Y9
names: Similarity
messages: Belongs to the CMC4 family.

9258:LOC100090298
gene id: 9258:LOC100090298
uniprot id: A0A6I8N8F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

9258:PLAC8L1
gene id: 9258:PLAC8L1
uniprot id: K7EH55
names: Similarity
messages: Belongs to the cornifelin family.

9258:FUT9
gene id: 9258:FUT9
uniprot id: F7D2K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9258:PLA2G4A
gene id: 9258:PLA2G4A
uniprot id: F6QDY0
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9258:MAPRE2
gene id: 9258:MAPRE2
uniprot id: F7C0X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9258:LOC100093297
gene id: 9258:LOC100093297
uniprot id: A0A6I8PF82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LOC100093349
gene id: 9258:LOC100093349
uniprot id: A0A6I8N139
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:LDB2
gene id: 9258:LDB2
uniprot id: F7FZZ4
names: Similarity
messages: Belongs to the LDB family.

9258:ASPN
gene id: 9258:ASPN
uniprot id: F7CWY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9258:MYF5
gene id: 9258:MYF5
uniprot id: F7DJV8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9258:LOC100093226
gene id: 9258:LOC100093226
uniprot id: A0A6I8N7N1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:TMEM14A
gene id: 9258:TMEM14A
uniprot id: A0A6I8N849
names: Similarity
messages: Belongs to the TMEM14 family.

9258:LOC100093253
gene id: 9258:LOC100093253
uniprot id: A0A6I8N7N1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:IFN4
gene id: 9258:IFN4
uniprot id: A8E6D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9258:IGF2BP3
gene id: 9258:IGF2BP3
uniprot id: F7BHT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9258:ZGPAT
gene id: 9258:ZGPAT
uniprot id: F7E9I2
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CHD4/Mi-2; the interaction is direct.
messages: Nucleus

9258:LOC100089396
gene id: 9258:LOC100089396
uniprot id: F7DNX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:SPTSSB
gene id: 9258:SPTSSB
uniprot id: A0A6I8NZ87
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:LOC103170898
gene id: 9258:LOC103170898
uniprot id: K7EGU8
names: Similarity
messages: Belongs to the MS4A family.

9258:SERPINC1
gene id: 9258:SERPINC1
uniprot id: F6QFN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

9258:ORNANAV1R3131
gene id: 9258:ORNANAV1R3131
uniprot id: A0A6I8PEU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:TRH
gene id: 9258:TRH
uniprot id: A0A6I8P3Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Secreted

9258:NQO1
gene id: 9258:NQO1
uniprot id: A0A6I8N977
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9258:DTNBP1
gene id: 9258:DTNBP1
uniprot id: F6TUH2
names: Similarity
messages: Belongs to the dysbindin family.

9258:DDX50
gene id: 9258:DDX50
uniprot id: A0A6I8PGH6
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9258:LNPK
gene id: 9258:LNPK
uniprot id: A0A6I8P7D7
uniprot id: F6XHY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9258:ARPC1B
gene id: 9258:ARPC1B
uniprot id: F6QT91
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9258:LOC100089126
gene id: 9258:LOC100089126
uniprot id: A0A6I8N139
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:PTTG1
gene id: 9258:PTTG1
uniprot id: F6VVC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9258:GRK1
gene id: 9258:GRK1
uniprot id: F7G4E7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9258:DOLPP1
gene id: 9258:DOLPP1
uniprot id: F7E622
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

9258:LOC100085268
gene id: 9258:LOC100085268
uniprot id: F7A0R6
names: Subcellular Location Annotation
messages: Nucleus

9258:ATP6V1D
gene id: 9258:ATP6V1D
uniprot id: A0A6I8P5K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9258:IFNB1
gene id: 9258:IFNB1
uniprot id: A8E6E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9258:RTN4
gene id: 9258:RTN4
uniprot id: A0A6I8NYA0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9258:NR2F2
gene id: 9258:NR2F2
uniprot id: A0A6I8PC22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9258:STARD6
gene id: 9258:STARD6
uniprot id: A0A6I8NQ99
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9258:PEPD
gene id: 9258:PEPD
uniprot id: F7EWS1
names: Similarity
messages: Belongs to the peptidase M24B family.

9258:LOC100083516
gene id: 9258:LOC100083516
uniprot id: F7G4L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:RPL35A
gene id: 9258:RPL35A
uniprot id: F7FJB8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9258:KEF28 p10
gene id: 9258:KEF28_p10
uniprot id: Q37718
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9258:ATG4C
gene id: 9258:ATG4C
uniprot id: F6PL45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9258:LOC100079342
gene id: 9258:LOC100079342
uniprot id: F6QQD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9258:LOC100073653
gene id: 9258:LOC100073653
uniprot id: F7FG67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9258:LOC100093160
gene id: 9258:LOC100093160
uniprot id: F6PX78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9258:CYP1A1
gene id: 9258:CYP1A1
uniprot id: A0A6I8N405
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9258:LOC100076934
gene id: 9258:LOC100076934
uniprot id: F7FI82
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9258:LOC100087699
gene id: 9258:LOC100087699
uniprot id: F7GDF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:KCNA10
gene id: 9258:KCNA10
uniprot id: F7A2P0
names: Subcellular Location Annotation
messages: Membrane

9258:ORNANAV1R3052
gene id: 9258:ORNANAV1R3052
uniprot id: F7D2N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9258:LOC100080576
gene id: 9258:LOC100080576
uniprot id: F7B1W2
names: Subcellular Location Annotation
messages: Secreted

9258:SGTA
gene id: 9258:SGTA
uniprot id: F7E1T8
names: Similarity
messages: Belongs to the SGT family.

9258:GPR1
gene id: 9258:GPR1
uniprot id: F6QIU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9258:DYNLL2
gene id: 9258:DYNLL2
uniprot id: A0A6I8PHH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9258:CDC25B
gene id: 9258:CDC25B
uniprot id: F7DQ48
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9258:MALL
gene id: 9258:MALL
uniprot id: F6TYK1
names: Subcellular Location Annotation
messages: Membrane

9258:CLTA
gene id: 9258:CLTA
uniprot id: F7DGD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9258:LOC100079726
gene id: 9258:LOC100079726
uniprot id: F6V1L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9258:ST3GAL1
gene id: 9258:ST3GAL1
uniprot id: A0A6I8NMZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9258:SLC16A7
gene id: 9258:SLC16A7
uniprot id: F6SS38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9258:PSMB2
gene id: 9258:PSMB2
uniprot id: F7CSY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9258:LTB
gene id: 9258:LTB
uniprot id: A7X5T4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9258:MET
gene id: 9258:MET
uniprot id: Q07E01
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by PTPN1 and PTPN2 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity. Interacts with tensin TNS3 (By similarity). Interacts (when phosphorylated) with tensin TNS4 (via SH2 domain); the interaction increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation (By similarity).
messages: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).
messages: Membrane
messages: O-mannosylation of IPT/TIG domains by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).
messages: The beta-propeller Sema domain mediates binding to HGF.
messages: The kinase domain is involved in SPSB1 binding.
messages: Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).

9258:METTL2A
gene id: 9258:METTL2A
uniprot id: F6QF05
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9258:ATG16L1
gene id: 9258:ATG16L1
uniprot id: A0A6I8NZ85
uniprot id: A0A6I8P2E3
uniprot id: F7A1C6
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9258:SV2C
gene id: 9258:SV2C
uniprot id: A0A6I8NJ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9258:SIX2
gene id: 9258:SIX2
uniprot id: F7C4U0
names: Subcellular Location Annotation
messages: Nucleus

9258:POP7
gene id: 9258:POP7
uniprot id: A0A6I8NRR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9258:CD36
gene id: 9258:CD36
uniprot id: F7FSF4
names: Similarity
messages: Belongs to the CD36 family.

9258:LOC100081857
gene id: 9258:LOC100081857
uniprot id: F6Y994
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9258:LOC100077197
gene id: 9258:LOC100077197
uniprot id: F7B3D4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9258:RBP2
gene id: 9258:RBP2
uniprot id: F6ZLK1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.