9031:H2AFJ
gene id: 9031:H2AFJ
uniprot id: P70082
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-120 (H2AXK119ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:FZD1
gene id: 9031:FZD1
uniprot id: O57328
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Expressed in the lens, otic placode (medial wall of the vesicle) and in epibranchial placode. Also expressed in the developing somites (dermomyotome).
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
messages: Somites and placodal expression appears at stage 9. At this stage, more obvious expression is detected in the neural tube (midbrain and rostral hindbrain), and persists through about stage 15. Strongly expressed in the ectoderm and around the otic placodes at stage 12. At stage 16, otic expression declines, expression in epibranchial placodes begins and peaks at stage 20. Expression in the lens of the eye is first seen at about stage 15, more evident at stage 16. At stage 17, seen in the ectoderm and mesenchyme of the limb primordia. Detected at stage 20 in the lip of the optic cup, in the mesenchyme surrounding the eye, in the ectoderm overlying the lens and in the ectoderm caudal and ventral of the olfactory placodes. From stages 20-30, expressed in cartilage and in the dermomyotomes and migrating sclerotomal cells forming vertebrae.
messages: The FZ domain is involved in binding with Wnt ligands.

9031:FGFR3
gene id: 9031:FGFR3
uniprot id: A0A8V0YYZ7
uniprot id: A0A8V0YZ02
uniprot id: P18460
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Monomer. Homodimer after ligand binding (By similarity).
messages: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans.
messages: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).

9031:TMEM9B
gene id: 9031:TMEM9B
uniprot id: E1C0E5
names: Similarity
messages: Belongs to the TMEM9 family.

9031:IFNG
gene id: 9031:IFNG
uniprot id: P49708
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).
messages: Secreted

9031:YWHAG
gene id: 9031:YWHAG
uniprot id: Q5F3W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.

9031:TGFA
gene id: 9031:TGFA
uniprot id: Q6J1M9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:EGR1
gene id: 9031:EGR1
uniprot id: Q5ZLU9
uniprot id: Q8QG62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9031:UBE2D2
gene id: 9031:UBE2D2
uniprot id: A0A8V0YK45
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:MARK3
gene id: 9031:MARK3
uniprot id: A0A8V0YV42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9031:NDC80
gene id: 9031:NDC80
uniprot id: Q76I89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12829748). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores to spindle microtubules (By similarity).
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex, which is composed of at least NDC80/HEC1 and CDCA1. Interacts with CENPH.
messages: Nucleus
messages: kinetochore

9031:CATH1
gene id: 9031:CATH1
uniprot id: C4PFJ7
uniprot id: Q6QLQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cathelicidin family.
messages: Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.
messages: Detected in gizzard, liver, small intestine, large intestine, cloaca, bursa of Fabricius, gall bladder, lung, trachea, kidney, testis and bone marrow.
messages: Secreted

9031:SMAD7
gene id: 9031:SMAD7
uniprot id: A0A1D5PNY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9031:ELAVL2
gene id: 9031:ELAVL2
uniprot id: A0A3Q2UCB0
uniprot id: A0A8V0XVM9
uniprot id: R4GFW0
names: Similarity
messages: Belongs to the RRM elav family.

9031:CPLX2
gene id: 9031:CPLX2
uniprot id: R4GKR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9031:PEX7
gene id: 9031:PEX7
uniprot id: A0A8V0XGG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

9031:RPL21
gene id: 9031:RPL21
uniprot id: R4GIQ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9031:COG6
gene id: 9031:COG6
uniprot id: A0A3Q2UCG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9031:SIGMAR1
gene id: 9031:SIGMAR1
uniprot id: Q5ZL84
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Homotrimer (By similarity).
messages: May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile.
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.

9031:ZP4
gene id: 9031:ZP4
uniprot id: Q9W645
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Zona pellucida

9031:ENPP2
gene id: 9031:ENPP2
uniprot id: A0A8V0Y5J6
uniprot id: A0A8V0Y5K1
uniprot id: E2RUH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9031:TIMM9
gene id: 9031:TIMM9
uniprot id: Q1G7H1
uniprot id: Q5ZIR8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

9031:MYLK2
gene id: 9031:MYLK2
uniprot id: A2NBE2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May interact with centrin.

9031:CELF1
gene id: 9031:CELF1
uniprot id: Q5F3T7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Expressed in heart at embryonic day 14 (at protein level). Expressed in heart at embryonic day 8.
messages: Nucleus
messages: RNA-binding protein that may be involved in pre-mRNA alternative splicing, mRNA translation activation and stability.

9031:HMGCS1
gene id: 9031:HMGCS1
uniprot id: A0A1L1RZ64
uniprot id: P23228
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.
messages: Cytoplasm
messages: Homodimer.

9031:NAT
gene id: 9031:NAT
uniprot id: A0A8V0XNN0
uniprot id: P12275
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9031:PSIP1
gene id: 9031:PSIP1
uniprot id: Q5XXA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus
messages: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).

9031:HOXB8
gene id: 9031:HOXB8
uniprot id: Q9YH27
names: Subcellular Location Annotation
messages: Nucleus

9031:DENND5A
gene id: 9031:DENND5A
uniprot id: A0A1L1RT22
uniprot id: A0A8V0Z9M2
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CHRNA3
gene id: 9031:CHRNA3
uniprot id: P09481
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily.
messages: Cell membrane
messages: High levels in the developing ciliary and superior cervical ganglia.
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.
messages: Postsynaptic cell membrane

9031:DPM1
gene id: 9031:DPM1
uniprot id: E1C4N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9031:ABCB10
gene id: 9031:ABCB10
uniprot id: A0A8V0XY06
names: Subcellular Location Annotation
messages: Membrane

9031:DPEP2
gene id: 9031:DPEP2
uniprot id: A0A8V1A2D7
uniprot id: F1NQJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9031:CCDC85A
gene id: 9031:CCDC85A
uniprot id: A0A1L1RJ65
uniprot id: A0A1L1RR59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9031:RAP1GAP2
gene id: 9031:RAP1GAP2
uniprot id: Q5ZMV8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

9031:TFAP2B
gene id: 9031:TFAP2B
uniprot id: A0A8V0XPT7
uniprot id: A0A8V0XW25
uniprot id: O93346
names: Similarity
messages: Belongs to the AP-2 family.

9031:RICTOR
gene id: 9031:RICTOR
uniprot id: F1NMJ6
names: Similarity
messages: Belongs to the RICTOR family.

9031:GTF2A2
gene id: 9031:GTF2A2
uniprot id: A1IIE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9031:SMC6
gene id: 9031:SMC6
uniprot id: E1BWW3
names: Subcellular Location Annotation
messages: Chromosome

9031:NIPA2
gene id: 9031:NIPA2
uniprot id: Q8AY37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9031:GAPVD1
gene id: 9031:GAPVD1
uniprot id: A0A3Q2TVQ8
uniprot id: E1C268
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9031:HOXA9
gene id: 9031:HOXA9
uniprot id: F1NJG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:GEM
gene id: 9031:GEM
uniprot id: Q76EY6
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9031:FAM103A1
gene id: 9031:FAM103A1
uniprot id: E1C6C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAM family.
messages: Nucleus

9031:C20H20ORF24
gene id: 9031:C20H20ORF24
uniprot id: Q5ZMJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:OC3
gene id: 9031:OC3
uniprot id: E6Y2E2
names: Similarity
messages: Belongs to the osteocalcin/matrix Gla protein family.

9031:CENPW
gene id: 9031:CENPW
uniprot id: P0DJH6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Association with CENPA-containing complexes may be indirect and due to the proximity of centromeric nucleosomes containing histone H3 with those containing CENPA.
messages: Belongs to the CENP-W/WIP1 family.
messages: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
messages: Heterodimer with CENPT; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex, which is a subcomplex of the large constitutive centromere-associated network (CCAN, also known as the interphase centromere complex or ICEN) (PubMed:19070575, PubMed:21464230, PubMed:22304917). Interacts with NPM1 (By similarity).
messages: Nucleus
messages: centromere
messages: kinetochore

9031:CDR2
gene id: 9031:CDR2
uniprot id: Q5ZJA3
names: Similarity
messages: Belongs to the CDR2 family.

9031:RPS24
gene id: 9031:RPS24
uniprot id: A0A8V0ZEF0
uniprot id: F1NF89
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

9031:TLDC1
gene id: 9031:TLDC1
uniprot id: Q5ZJX5
names: Function
names: Subcellular Location Annotation
messages: Activates an alternative mTOR signaling to regulate cell proliferation and migration.
messages: Cytoplasm
messages: Lysosome
messages: Membrane

9031:ANP32E
gene id: 9031:ANP32E
uniprot id: Q5F4A3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANP32 family.
messages: Component of a SWR1-like complex. Interacts with H2A.Z/H2AZ1 (By similarity).
messages: Cytoplasm
messages: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis (By similarity).
messages: Nucleus
messages: The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AZ1.

9031:SURF4
gene id: 9031:SURF4
uniprot id: Q800K9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

9031:EDEM3
gene id: 9031:EDEM3
uniprot id: A0A1D5PEI6
uniprot id: A0A8V0YJ07
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9031:PPM1B
gene id: 9031:PPM1B
uniprot id: A0A1D5PF07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9031:CD40LG
gene id: 9031:CD40LG
uniprot id: B6RCP9
uniprot id: Q9I8D8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer (By similarity). Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Homotrimer.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9031:RASGRP3
gene id: 9031:RASGRP3
uniprot id: Q5ZID9
names: Similarity
messages: Belongs to the RASGRP family.

9031:OPRL1
gene id: 9031:OPRL1
uniprot id: R4GF58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

9031:H2AFY2
gene id: 9031:H2AFY2
uniprot id: E1BR08
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9031:LNPEP
gene id: 9031:LNPEP
uniprot id: F1NNE7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9031:SLC37A4
gene id: 9031:SLC37A4
uniprot id: F1NTH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9031:SMAD2
gene id: 9031:SMAD2
uniprot id: Q8UWF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9031:FECH
gene id: 9031:FECH
uniprot id: O42479
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferrochelatase family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane
messages: Monomer.

9031:EDN1
gene id: 9031:EDN1
uniprot id: A0A4P9IUV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9031:MYOZ2
gene id: 9031:MYOZ2
uniprot id: A0A1L1RJB3
names: Similarity
messages: Belongs to the myozenin family.

9031:PCDHA3
gene id: 9031:PCDHA3
uniprot id: Q6R0I8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:SLC6A17
gene id: 9031:SLC6A17
uniprot id: F1NS02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:CLSTN1
gene id: 9031:CLSTN1
uniprot id: A0A8V0YZ96
uniprot id: A0A8V0YZM5
uniprot id: E1BYQ5
uniprot id: Q9DDD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsyntenin family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Postsynaptic cell membrane

9031:OR51M1
gene id: 9031:OR51M1
uniprot id: Q9YH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:JAK3
gene id: 9031:JAK3
uniprot id: O42291
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system

9031:TMEM57
gene id: 9031:TMEM57
uniprot id: Q2TLY9
uniprot id: Q5ZLJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

9031:KTN1
gene id: 9031:KTN1
uniprot id: Q90631
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytoplasmic form lacking the first 232 amino acids has been characterized.
messages: Belongs to the kinectin family.
messages: Both the membrane and cytoplasmic forms seem to be myristoylated.
messages: Endoplasmic reticulum membrane
messages: Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.
messages: Receptor for kinesin thus involved in kinesin-driven vesicle motility.

9031:SRSF2
gene id: 9031:SRSF2
uniprot id: P30352
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA.
messages: Nucleus

9031:CLDN5
gene id: 9031:CLDN5
uniprot id: Q98SR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:EIF2B2
gene id: 9031:EIF2B2
uniprot id: Q5ZL25
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9031:ASB8
gene id: 9031:ASB8
uniprot id: Q5ZHY6
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9031:DENR
gene id: 9031:DENR
uniprot id: Q5ZJ39
names: Function
names: Similarity
messages: Belongs to the DENR family.
messages: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).

9031:PNAT3
gene id: 9031:PNAT3
uniprot id: P13914
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9031:RAB9A
gene id: 9031:RAB9A
uniprot id: Q5ZMI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: phagosome membrane

9031:STIM1
gene id: 9031:STIM1
uniprot id: Q5ZIJ6
names: Subcellular Location Annotation
messages: Membrane

9031:SLC22A4
gene id: 9031:SLC22A4
uniprot id: C0MP42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9031:P2RX4
gene id: 9031:P2RX4
uniprot id: Q9YI70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9031:RPS6KA5
gene id: 9031:RPS6KA5
uniprot id: Q5F3L1
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by phosphorylation at Ser-350, Thr-571 and Thr-690 by MAP kinases, and by further autophosphorylation of Ser-202, Ser-366 and Ser-371 by the activated C-terminal kinase domain. The active N-terminal kinase domain finally phosphorylates downstream substrates, as well as Ser-740, Ser-742 and Ser-748 in its own C-terminal region (By similarity).
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: Enzyme activity requires the presence of both kinase domains.
messages: Nucleus
messages: Ser-366 and Thr-571 phosphorylation is required for kinase activity. Ser-366 and Ser-202 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-350, Thr-571 and Thr-690 by MAP kinases. Autophosphorylated at Ser-740, Ser-742 and Ser-748 by the N-terminal kinase domain.
messages: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and that contributes to gene activation by histone phosphorylation. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (By similarity).
messages: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.

9031:AACS
gene id: 9031:AACS
uniprot id: Q5ZLG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity).
messages: cytosol

9031:GNG2
gene id: 9031:GNG2
uniprot id: Q5ZJ03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9031:SLC9A3
gene id: 9031:SLC9A3
uniprot id: A0A1D5NYQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

9031:TMEM18
gene id: 9031:TMEM18
uniprot id: Q5F410
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Nucleus membrane

9031:NME2
gene id: 9031:NME2
uniprot id: O57535
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cell membrane
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

9031:LOC423731
gene id: 9031:LOC423731
uniprot id: F1P225
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9031:STAC
gene id: 9031:STAC
uniprot id: A0A1D5P8F5
uniprot id: A0A8V0Z676
names: Subcellular Location Annotation
messages: sarcolemma

9031:ELF2
gene id: 9031:ELF2
uniprot id: E1C717
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:CCDC58
gene id: 9031:CCDC58
uniprot id: A0A1L1RWZ8
names: Similarity
messages: Belongs to the MIX23 family.

9031:MRPL24
gene id: 9031:MRPL24
uniprot id: A0A1D5P3Y4
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9031:UBE2F
gene id: 9031:UBE2F
uniprot id: Q5ZKX6
names: Function
names: Similarity
names: Subunit
messages: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
messages: Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
messages: Interacts with UBA3 and RBX2.

9031:ARID1A
gene id: 9031:ARID1A
uniprot id: A0A8V0YQD7
names: Subcellular Location Annotation
messages: Nucleus

9031:PHF5A
gene id: 9031:PHF5A
uniprot id: E1BV20
names: Similarity
messages: Belongs to the PHF5 family.

9031:LMOD3
gene id: 9031:LMOD3
uniprot id: A0A8V0ZJ39
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9031:SEPTIN8
gene id: 9031:SEPTIN8
uniprot id: A0A3Q2U387
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9031:MARVELD1
gene id: 9031:MARVELD1
uniprot id: A0A8V0ZT33
names: Subcellular Location Annotation
messages: Membrane

9031:AIG1
gene id: 9031:AIG1
uniprot id: E1BS86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9031:BLM
gene id: 9031:BLM
uniprot id: Q9I920
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:28228481). Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair (By similarity). Negatively regulates sister chromatid exchange (SCE) (By similarity). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (By similarity). Binds DNA (PubMed:28228481). Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity).
messages: Belongs to the helicase family. RecQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer (PubMed:28228481). Homodimer (via N-terminus) (PubMed:28228481). Homotetramer (via N-terminus); dimer of dimers (PubMed:28228481). Homohexamer (via N-terminus) (PubMed:28228481). Self-association negatively regulates DNA unwinding amplitude and rate (PubMed:28228481). Oligomer complexes dissociate into monomer in presence of ATP (PubMed:28228481).
messages: Nucleus
messages: The N-terminal region mediates dimerization and homooligomerization (PubMed:28228481). Both the helicase ATP-binding domain and the helicase C-terminal domain form intramolecular interactions with the HRDC domain in a ATP-dependent manner (By similarity). The HRDC domain is required for single-stranded DNA (ssDNA) and DNA Holliday junction binding (By similarity).

9031:GPAT3
gene id: 9031:GPAT3
uniprot id: Q5ZLL8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Protects cells against lipotoxicity.
messages: Endoplasmic reticulum membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9031:VTG1
gene id: 9031:VTG1
uniprot id: P87498
names: Allergen
names: Function
names: Induction
names: PTM
names: Tissue Specificity
messages: By steroids (estrogen).
messages: Cathepsin D is responsible for intraoocytic processing of vitellogenin.
messages: Causes an allergic reaction in human (PubMed:26897338). Binds to IgE (PubMed:20509661, PubMed:26897338).
messages: May contain intrachain disulfide bonds.
messages: Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo.
messages: Phosvitin, an egg yolk storage protein, is one of the most highly phosphorylated (10%) proteins in nature.
messages: Precursor of the egg-yolk proteins that are sources of nutrients during early development of oviparous organisms.
messages: Produced by the liver, secreted into the blood and then sequestered by receptor mediated endocytosis into growing oocytes, where it is generally cleaved, giving rise to the respective yolk components.

9031:AQP1
gene id: 9031:AQP1
uniprot id: Q2MCJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9031:PLA2G10
gene id: 9031:PLA2G10
uniprot id: D6NKG6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9031:NUDT1
gene id: 9031:NUDT1
uniprot id: F7BGT1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

9031:HSPA8
gene id: 9031:HSPA8
uniprot id: O73885
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cell membrane
messages: Cytoplasm
messages: First detected at 0.5 days of embryonic development (at protein level). Detected at higher levels from 1 to 2.5 days of embryonic development (at protein level). First detected at 0.5 days of embryonic development. Levels increase strongly from 1 to 2.5 days of embryonic development.
messages: Lysosome membrane
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes (By similarity). Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (By similarity). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (By similarity). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state (By similarity). In the ATP-bound form, it has a low affinity for substrate proteins (By similarity). However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins (By similarity). HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (By similarity). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (By similarity). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (By similarity). May play a role in regulating apoptosis during embryonic development (PubMed:9707581).
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
messages: Up-regulated by insulin in cultured embryos.
messages: nucleolus

9031:SNX13
gene id: 9031:SNX13
uniprot id: A0A8V0XGW3
names: Similarity
messages: Belongs to the sorting nexin family.

9031:NPY7R
gene id: 9031:NPY7R
uniprot id: Q30D05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:RAB18
gene id: 9031:RAB18
uniprot id: Q5ZLG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Also required for maintaining endoplasmic reticulum structure (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (By similarity).

9031:SLC23A2
gene id: 9031:SLC23A2
uniprot id: B9VMA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9031:STAT5A
gene id: 9031:STAT5A
uniprot id: B9VVJ4
uniprot id: O93378
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9031:FBXL5
gene id: 9031:FBXL5
uniprot id: A0A8V0Y5Q9
names: Subcellular Location Annotation
messages: perinuclear region

9031:AKR1B10
gene id: 9031:AKR1B10
uniprot id: Q90W83
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9031:TNFRSF9
gene id: 9031:TNFRSF9
uniprot id: A0A3Q2UM48
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GPR132
gene id: 9031:GPR132
uniprot id: R4GHJ0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:WASL
gene id: 9031:WASL
uniprot id: E1BTH9
names: Subcellular Location Annotation
messages: Nucleus

9031:ZBTB8OS
gene id: 9031:ZBTB8OS
uniprot id: F1NMM3
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

9031:NRCAM
gene id: 9031:NRCAM
uniprot id: P35331
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Cell membrane
messages: Expressed in developing neural retina and embryonic brain tissue.
messages: Heterodimer of an alpha and a beta chain.
messages: Retina and developing brain.
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Specifically involved in the development of optic fibres in the retina.

9031:RAG2
gene id: 9031:RAG2
uniprot id: A0A1L1RM35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9031:INPP5K
gene id: 9031:INPP5K
uniprot id: Q5ZLZ2
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9031:TPM1
gene id: 9031:TPM1
uniprot id: A0A8V0ZYC6
uniprot id: P04268
uniprot id: Q8AWI4
uniprot id: Q91005
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
messages: Homodimer (PubMed:23832280). Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity). Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG (PubMed:15269838, PubMed:15313924).
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

9031:ZRANB1
gene id: 9031:ZRANB1
uniprot id: A0A1D5PDU1
names: Similarity
messages: Belongs to the peptidase C64 family.

9031:LOXL2
gene id: 9031:LOXL2
uniprot id: A0A0A0MQ32
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9031:MAU2
gene id: 9031:MAU2
uniprot id: A0A8V1AEC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9031:ZBTB14
gene id: 9031:ZBTB14
uniprot id: Q92010
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Interacts with ZBTB21.
messages: Nucleus
messages: The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus.
messages: Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters (By similarity).

9031:TMEM104
gene id: 9031:TMEM104
uniprot id: Q5F3I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM104 family.
messages: Membrane

9031:MAOB
gene id: 9031:MAOB
uniprot id: A0A1D5PI43
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9031:LFNG
gene id: 9031:LFNG
uniprot id: O12971
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: A soluble form may be derived from the membrane form by proteolytic processing.
messages: At stage 13 it is detected in the presomitic mesoderm, transiently observed before segmentation, and in the rostral part of the neural tube. Up-regulated in the neural tube, the retina and the otic vesicle from this stage on. At stage 17 a distinct stripe pattern was clear in the hindbrain and the spinal chord. Also found in the neuroepithelium of the midbrain and forebrain. The expression was down-regulated with the termination of neurogenesis at stage 36.
messages: Belongs to the glycosyltransferase 31 family.
messages: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning.
messages: Golgi apparatus membrane

9031:HSPA4L
gene id: 9031:HSPA4L
uniprot id: Q5F3J8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9031:SPOPL
gene id: 9031:SPOPL
uniprot id: A0A3Q3AA02
names: Similarity
messages: Belongs to the Tdpoz family.

9031:ZC3HAV1
gene id: 9031:ZC3HAV1
uniprot id: Q5F3B3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:CSRNP2
gene id: 9031:CSRNP2
uniprot id: A0A1D5PNW1
uniprot id: A0A8V0ZUZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9031:HOXA7
gene id: 9031:HOXA7
uniprot id: Q90VZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:KRT5
gene id: 9031:KRT5
uniprot id: Q6PVZ5
names: Similarity
messages: Belongs to the intermediate filament family.

9031:NSDHL
gene id: 9031:NSDHL
uniprot id: E1C279
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9031:SCUBE3
gene id: 9031:SCUBE3
uniprot id: A0A8V1AC12
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:FABP2
gene id: 9031:FABP2
uniprot id: Q7ZZZ5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9031:ALDH1A2
gene id: 9031:ALDH1A2
uniprot id: O93344
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (By similarity). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Lacks activity with benzaldehyde, acetaldehyde and octanal (By similarity). Displays complete lack of activity with citral (By similarity).
messages: Cytoplasm
messages: Homotetramer.

9031:TBP
gene id: 9031:TBP
uniprot id: O13270
uniprot id: Q6JLB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBP family.
messages: Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.
messages: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
messages: Nucleus

9031:OR52R1
gene id: 9031:OR52R1
uniprot id: A0A8V0XJI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:FABP4
gene id: 9031:FABP4
uniprot id: Q90X55
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9031:RPL26L1
gene id: 9031:RPL26L1
uniprot id: F2Z4K6
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9031:TBX18
gene id: 9031:TBX18
uniprot id: Q68SB0
uniprot id: Q7T2Z6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:TRAPPC2L
gene id: 9031:TRAPPC2L
uniprot id: A0A8V0XUM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9031:RNASEH1
gene id: 9031:RNASEH1
uniprot id: Q91953
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9031:TIPARP
gene id: 9031:TIPARP
uniprot id: F1N973
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:FXR1
gene id: 9031:FXR1
uniprot id: A0A8V0YXD7
uniprot id: A0A8V0YYW1
uniprot id: Q5F3S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasmic ribonucleoprotein granule

9031:CPPED1
gene id: 9031:CPPED1
uniprot id: A0A1D5PJC6
uniprot id: A0A8V0ZCV8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.

9031:NFKB2
gene id: 9031:NFKB2
uniprot id: P98150
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NF-kappa-B RelB-p52 complex.
messages: Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named PID, which contains the death domain.
messages: Cytoplasm
messages: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the en…
messages: NF-kappa-B p100 is one of the high-molecular-weight proteins complexed with the v-rel oncoprotein in transformed chicken spleen cells.
messages: Nucleus
messages: The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation.
messages: The glycine-rich region (GRR) appears to be a critical element in the generation of p52.
messages: While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p52 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing (By similarity).

9031:PARP16
gene id: 9031:PARP16
uniprot id: A0A8V0Z4H7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:SLC9A8
gene id: 9031:SLC9A8
uniprot id: A0A8V0YCF0
uniprot id: Q5ZJ75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Golgi apparatus membrane
messages: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).

9031:COR1
gene id: 9031:COR1
uniprot id: P37067
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Odorant receptor.

9031:GABRA3
gene id: 9031:GABRA3
uniprot id: A0A8V0YJK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:CHGA
gene id: 9031:CHGA
uniprot id: F1NLZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9031:RPS6KA1
gene id: 9031:RPS6KA1
uniprot id: A0A3Q2U5L9
uniprot id: A0A3Q3ADZ8
uniprot id: A0A3Q3AVG7
uniprot id: A0A8V0YQT6
uniprot id: P18652
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Activated by multiple phosphorylations on threonine and serine residues.
messages: Autophosphorylated on Ser-398, as part of the activation process.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription.
messages: Small and large intestine, spleen, stomach, and bursa, and to a lesser extent lung and kidney.

9031:NPSR1
gene id: 9031:NPSR1
uniprot id: A0A1D5PKZ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:METAP1
gene id: 9031:METAP1
uniprot id: Q5ZIM5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 60S ribosomal subunit of the 80S translational complex.
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

9031:FGB
gene id: 9031:FGB
uniprot id: Q02020
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
messages: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots.
messages: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9031:MAPK4
gene id: 9031:MAPK4
uniprot id: Q5F3W3
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.
messages: Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity).
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

9031:PRPS2
gene id: 9031:PRPS2
uniprot id: Q5ZI49
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3-bisphosphoglyceride or GDP (By similarity).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).

9031:CAMLG
gene id: 9031:CAMLG
uniprot id: Q90700
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9031:MTX2
gene id: 9031:MTX2
uniprot id: E1BVN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9031:BORCS7
gene id: 9031:BORCS7
uniprot id: A0A1L1RK18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Lysosome membrane
messages: Membrane

9031:SLC35F4
gene id: 9031:SLC35F4
uniprot id: F1NF95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9031:VDHAP
gene id: 9031:VDHAP
uniprot id: Q90578
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amidase family.
messages: Kidney.
messages: May have a vitamin D3 hydroxylase regulatory function.
messages: Mitochondrion inner membrane

9031:SPI1
gene id: 9031:SPI1
uniprot id: O42415
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:PLEKHF2
gene id: 9031:PLEKHF2
uniprot id: Q5ZLY5
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endoplasmic reticulum
messages: May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.
messages: The FYVE domain is important for binding to the endosomal membrane.

9031:SURF1
gene id: 9031:SURF1
uniprot id: Q800L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: May play a role in mitochondrial respiratory chain complex IV assembly. Probably involved in the biogenesis of the COX complex.
messages: Mitochondrion inner membrane

9031:VDAC2
gene id: 9031:VDAC2
uniprot id: Q9I9D1
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9031:DYRK1A
gene id: 9031:DYRK1A
uniprot id: Q8JG32
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9031:SLC35F2
gene id: 9031:SLC35F2
uniprot id: E1C0P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9031:NEUROD4
gene id: 9031:NEUROD4
uniprot id: A0A1D5PPH1
uniprot id: P79766
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Expressed in both the developing central nervous system and peripheral nervous system.
messages: Expression in the developing nervous system is transient and restricted to cells lining the ventricular zone that have ceased proliferation but have not yet begun to migrate into the outer layers. In retina, neurom is also transiently expressed in cells as they withdraw from the mitotic cycle, but persists in horizontal and bipolar neurons until full differentiation. In the peripheral nervous system, its expression closely follows cell proliferation.
messages: Nucleus
messages: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).
messages: Serine or threonine phosphorylation within the basic region may regulate neurogenic activity.

9031:PRKD3
gene id: 9031:PRKD3
uniprot id: E1C6T4
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9031:MAF
gene id: 9031:MAF
uniprot id: Q789F3
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE).
messages: Belongs to the bZIP family. Maf subfamily.
messages: Expressed in kidney, brain, lung, gut, mesenterium, testis and ovary.
messages: Expressed in the lens placode at stage 14. Expressed at stage 18 when the invaginating lens placode closes to form the lens vesicle.
messages: Homodimer or heterodimer. Binds DNA as a homodimer or a heterodimer. Interacts with HOXD12, PAX6 and PRRX1; interaction is direct and inhibits its DNA-binding and transactivating activity.
messages: Nucleus
messages: The basic region and the leucine zipper structure are necessary for association with HOXD12 and PRRX1.

9031:DCTN5
gene id: 9031:DCTN5
uniprot id: F1N8W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

9031:PLAG1
gene id: 9031:PLAG1
uniprot id: Q58NQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed in nephroblastoma.
messages: Nucleus
messages: Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation.

9031:CNRIP1
gene id: 9031:CNRIP1
uniprot id: E1BU35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9031:HSPB2
gene id: 9031:HSPB2
uniprot id: Q6KCP2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

9031:SCNN1A
gene id: 9031:SCNN1A
uniprot id: Q92075
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties.
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
messages: The long isoform has been found in cochlea, colon, and cartilage. The short isoform is only found in cochlea.
messages: acrosome
messages: cilium
messages: flagellum

9031:RPS3
gene id: 9031:RPS3
uniprot id: Q5ZJC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: spindle

9031:OLAH
gene id: 9031:OLAH
uniprot id: A0A8V0X6Y8
names: Similarity
messages: Belongs to the thioesterase family.

9031:RAB5C
gene id: 9031:RAB5C
uniprot id: Q98932
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Detected in brain, ovary, rectum, small intestine, large intestine, liver, spleen, follicle and kidney (at protein level).
messages: Early endosome membrane
messages: Protein transport. Probably involved in vesicular traffic.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

9031:PGS1
gene id: 9031:PGS1
uniprot id: Q5ZHN9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated by calcium and magnesium and inhibited by other bivalent cations.
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9031:ERO1A
gene id: 9031:ERO1A
uniprot id: A0A8V0Z5W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9031:SYK
gene id: 9031:SYK
uniprot id: F1N9Y5
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region) to parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of the interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane proteins disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation. The phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially mediated by SRC subfamily kinases, like LYN, upon transmembrane receptors engagement. Downstream signaling adapters and intermediates may mediate positive and/or negative feedback regulation (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
messages: Cell membrane
messages: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors.
messages: The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins.
messages: cytosol

9031:RHBG
gene id: 9031:RHBG
uniprot id: A0A8V1AI86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9031:CDK5RAP3
gene id: 9031:CDK5RAP3
uniprot id: Q5F3L8
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9031:FGFBP2
gene id: 9031:FGFBP2
uniprot id: Q802A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibroblast growth factor-binding protein family.
messages: extracellular space

9031:LOC769139
gene id: 9031:LOC769139
uniprot id: A0A8V1AH11
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:CPSF6
gene id: 9031:CPSF6
uniprot id: A0A1D5P9A5
uniprot id: F1NGU9
uniprot id: Q5ZL34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM CPSF6/7 family.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. Plays a role in mRNA export.
messages: Component of the cleavage factor Im (CFIm) complex.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: nucleoplasm

9031:AFF4
gene id: 9031:AFF4
uniprot id: A0A8V0YL30
uniprot id: A0A8V0YLL1
names: Similarity
messages: Belongs to the AF4 family.

9031:NTNG1
gene id: 9031:NTNG1
uniprot id: A0A1D5NW03
uniprot id: A0A8V0Y6K5
uniprot id: A0A8V0YBG8
uniprot id: A0A8V0YBI0
uniprot id: A0A8V0YF11
uniprot id: A0A8V0YF21
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CYP2AC1
gene id: 9031:CYP2AC1
uniprot id: F1NFF7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:BMPR1A
gene id: 9031:BMPR1A
uniprot id: F1P3H0
uniprot id: Q90754
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9031:TNNC2
gene id: 9031:TNNC2
uniprot id: P02588
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the troponin C family.
messages: Skeletal muscle troponin C binds four calcium ions.
messages: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

9031:SAP130
gene id: 9031:SAP130
uniprot id: Q5F3U0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity).
messages: Belongs to the SAP130 family.
messages: Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2.
messages: Nucleus
messages: The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors.
messages: The N-terminus may interact with a transcriptional coactivator.

9031:IMPG1
gene id: 9031:IMPG1
uniprot id: Q8JIR8
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundantly expressed in the retina (at protein level) (PubMed:11991949, PubMed:18466325, PubMed:18786170). Localizes to the photoreceptor layer of the interphotoreceptor matrix of the retina (at protein level) (PubMed:11991949).
messages: Chondroitin sulfate-, heparin- and hyaluronan-binding protein (PubMed:11991949, PubMed:18466325, PubMed:18786170). May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity).
messages: Expression is first detected in embryonic retina at 15 dpc and increases with developmental age.
messages: Highly glycosylated (N- and O-linked carbohydrates and sialic acid).
messages: Photoreceptor inner segment
messages: interphotoreceptor matrix
messages: photoreceptor outer segment

9031:VOPP1
gene id: 9031:VOPP1
uniprot id: A0A1L1RMG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9031:ADAM19
gene id: 9031:ADAM19
uniprot id: E1AP05
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ANKRD52
gene id: 9031:ANKRD52
uniprot id: Q5ZLC8
names: Function
names: Subunit
messages: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).
messages: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

9031:IL1RAPL1
gene id: 9031:IL1RAPL1
uniprot id: A0A8V0X4W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

9031:MTMR9LP
gene id: 9031:MTMR9LP
uniprot id: E1C6W8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9031:DKK2
gene id: 9031:DKK2
uniprot id: A0A3Q3B125
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9031:CYP2D6
gene id: 9031:CYP2D6
uniprot id: F1NJG4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:KIF4B
gene id: 9031:KIF4B
uniprot id: Q90640
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
messages: Binds 1 [4Fe-4S] cluster (By similarity). In the presence of oxygen, the [4Fe-4S] cluster may be converted to [2Fe-2S] (By similarity).
messages: Chromosome
messages: Expressed in proliferating cells; neuroepithelium of embryos.
messages: Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Required for mitotic chromosomal positioning and bipolar spindle stabilization.
messages: Nucleus
messages: cytoskeleton

9031:WASHC1
gene id: 9031:WASHC1
uniprot id: Q5ZKA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
messages: Belongs to the WASH1 family.
messages: Component of the WASH complex.
messages: Early endosome membrane
messages: Recycling endosome membrane
messages: The VCA (verprolin, cofilin, acidic) domain promotes actin polymerization by the Arp2/3 complex in vitro.

9031:HAL
gene id: 9031:HAL
uniprot id: Q802A0
names: Similarity
messages: Belongs to the PAL/histidase family.

9031:TMEM135
gene id: 9031:TMEM135
uniprot id: A0A8V0Y1H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane

9031:AP3M2
gene id: 9031:AP3M2
uniprot id: A0A1D5NUM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9031:POLD2
gene id: 9031:POLD2
uniprot id: A0A8V0ZG11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9031:RRP1B
gene id: 9031:RRP1B
uniprot id: Q5F481
names: Similarity
messages: Belongs to the RRP1 family.

9031:PHKB
gene id: 9031:PHKB
uniprot id: A0A8V0ZRS6
uniprot id: Q5ZME3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9031:DHX15
gene id: 9031:DHX15
uniprot id: Q5F3A9
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9031:TTYH3
gene id: 9031:TTYH3
uniprot id: F1NWU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9031:TGIF1
gene id: 9031:TGIF1
uniprot id: Q90655
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/TGIF homeobox family.
messages: Binds to the F' element of the APOVLDLII gene and represses its transcription.
messages: Nucleus

9031:HPDL
gene id: 9031:HPDL
uniprot id: E1BX51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9031:NCK1
gene id: 9031:NCK1
uniprot id: Q5ZK48
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9031:LACTB2
gene id: 9031:LACTB2
uniprot id: A0A8V0XK56
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9031:SLC4A1
gene id: 9031:SLC4A1
uniprot id: P15575
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric.
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Erythrocytes.
messages: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.

9031:CCDC93
gene id: 9031:CCDC93
uniprot id: Q5ZKI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC93 family.
messages: Early endosome
messages: May be involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery.

9031:NTL
gene id: 9031:NTL
uniprot id: A0A8V0ZID3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

9031:CYP2J21
gene id: 9031:CYP2J21
uniprot id: Q5ZHU7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:NEUROD6
gene id: 9031:NEUROD6
uniprot id: A0A3Q2U1V3
names: Subcellular Location Annotation
messages: Nucleus

9031:ICOS
gene id: 9031:ICOS
uniprot id: A6PZH9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9031:RPL3
gene id: 9031:RPL3
uniprot id: Q5ZJZ2
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9031:GPR87
gene id: 9031:GPR87
uniprot id: A0A8V0X448
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:PLTP
gene id: 9031:PLTP
uniprot id: C5H3Z3
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9031:MAP7
gene id: 9031:MAP7
uniprot id: A0A8V0XTH8
uniprot id: Q5ZIA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAP7 family.
messages: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells.
messages: cytoskeleton
messages: perinuclear region

9031:ZC3H12C
gene id: 9031:ZC3H12C
uniprot id: A0A8V0XDX2
names: Similarity
messages: Belongs to the ZC3H12 family.

9031:NADK2
gene id: 9031:NADK2
uniprot id: A0A8V0YUH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

9031:ADRB2
gene id: 9031:ADRB2
uniprot id: A0A1D5P7A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane

9031:IL2RG
gene id: 9031:IL2RG
uniprot id: Q8AUP2
uniprot id: Q8AV07
names: Subcellular Location Annotation
messages: Membrane

9031:LIN52
gene id: 9031:LIN52
uniprot id: Q5ZJQ3
names: Similarity
names: Subunit
messages: Belongs to the lin-52 family.
messages: Component of the DREAM complex.

9031:FAM76A
gene id: 9031:FAM76A
uniprot id: Q5ZJ65
names: Similarity
messages: Belongs to the FAM76 family.

9031:KPNA1
gene id: 9031:KPNA1
uniprot id: Q5ZML1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin alpha family.
messages: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
messages: Cytoplasm
messages: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
messages: Nucleus
messages: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
messages: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).

9031:DCP1A
gene id: 9031:DCP1A
uniprot id: A0A1D5PQ74
names: Similarity
messages: Belongs to the DCP1 family.

9031:LAPTM5
gene id: 9031:LAPTM5
uniprot id: A0A8V0YKH4
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9031:TMEM159
gene id: 9031:TMEM159
uniprot id: A0A8V0YZ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

9031:GREM1
gene id: 9031:GREM1
uniprot id: O73755
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling.
messages: In brain first detected at 6 dpc and persisted until 14 dpc. On 10 dpc brain, expressed in the dorsal region of the telencephalic hemispheres and cells located in the ventral diencephalon. On 14 dpc head, expressed in the meninges of the spinal cord. Expressed in the developing optic nerve and at the optic nerve/pecten junction.
messages: Secreted

9031:AGMAT
gene id: 9031:AGMAT
uniprot id: Q90XD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginase family. Agmatinase subfamily.
messages: Mitochondrion

9031:RXRA
gene id: 9031:RXRA
uniprot id: A0A1D5P2B5
uniprot id: A0A8V1A8J8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9031:GLIS1
gene id: 9031:GLIS1
uniprot id: F1ND41
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9031:PRDM1
gene id: 9031:PRDM1
uniprot id: A0A3Q2UNE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9031:SETD1A
gene id: 9031:SETD1A
uniprot id: Q5F3P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
messages: Nucleus speckle

9031:CLDN19
gene id: 9031:CLDN19
uniprot id: A0A3Q3A4L0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:C16orf72
gene id: 9031:C16orf72
uniprot id: E1BV25
names: Subcellular Location Annotation
messages: Nucleus

9031:PLRG1
gene id: 9031:PLRG1
uniprot id: A0A1L1RM96
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9031:BAG5
gene id: 9031:BAG5
uniprot id: Q5F486
names: Domain
names: Function
names: Subunit
messages: Binds to the ATPase domain of HSP/HSC70 chaperones.
messages: Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding.
messages: The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.

9031:TMEM8C
gene id: 9031:TMEM8C
uniprot id: A0A0D5WB77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9031:KLHL15
gene id: 9031:KLHL15
uniprot id: A0A1D5PIX2
uniprot id: F1NNV8
uniprot id: Q5ZJU2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Interacts with CUL3.
messages: Nucleus
messages: Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex.

9031:PPARG
gene id: 9031:PPARG
uniprot id: Q9I878
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9031:DDX52
gene id: 9031:DDX52
uniprot id: Q5F3Y6
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9031:RHCE
gene id: 9031:RHCE
uniprot id: Q7T0L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9031:CLDN2
gene id: 9031:CLDN2
uniprot id: E1C8Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:EVL
gene id: 9031:EVL
uniprot id: A0A8V0YY94
uniprot id: Q5ZIC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

9031:LHCGR
gene id: 9031:LHCGR
uniprot id: Q90674
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Additional isoforms seem to exist.
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Expressed in ovarian follicle granulosa cells (PubMed:9545511, PubMed:8828833). Expressed in ovarian follicle theca cells (PubMed:8828833).
messages: Expression levels are very low in 3-5mm, 6-8mm and 9-12mm ovarian follicles, but subsequently increase rapidly with high levels detected during F3, F2 and F1 preovulatory stages.
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9031:PRPF3
gene id: 9031:PRPF3
uniprot id: Q5ZJ85
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the precatalytic spliceosome (spliceosome B complex) (By similarity). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (By similarity). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9031:PSMD7
gene id: 9031:PSMD7
uniprot id: F1NR71
names: Similarity
messages: Belongs to the peptidase M67A family.

9031:TRIT1
gene id: 9031:TRIT1
uniprot id: E1C6R1
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9031:MND1
gene id: 9031:MND1
uniprot id: A0A8V0YGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

9031:MEOX1
gene id: 9031:MEOX1
uniprot id: Q9YI38
names: Subcellular Location Annotation
messages: Nucleus

9031:DCLRE1A
gene id: 9031:DCLRE1A
uniprot id: Q5QJC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Binds PIAS1.
messages: May be required for DNA interstrand cross-link repair.
messages: Nucleus

9031:RPL38
gene id: 9031:RPL38
uniprot id: E1BU66
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9031:MRPL51
gene id: 9031:MRPL51
uniprot id: Q5ZKG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity).
messages: Mitochondrion

9031:FH
gene id: 9031:FH
uniprot id: Q5ZLD1
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

9031:PRKAR1B
gene id: 9031:PRKAR1B
uniprot id: A0A1D5PCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9031:WDR24
gene id: 9031:WDR24
uniprot id: A0A3Q2U8E6
uniprot id: Q5ZMV9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR24 family.
messages: Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as a E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2.
messages: Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids.
messages: Lysosome membrane
messages: The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated.

9031:DYNLT1
gene id: 9031:DYNLT1
uniprot id: A0A3Q2U8X6
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9031:GFM1
gene id: 9031:GFM1
uniprot id: F1P0J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion
messages: Nucleus

9031:LOC768416
gene id: 9031:LOC768416
uniprot id: Q5ZI53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9031:HOXC12
gene id: 9031:HOXC12
uniprot id: A0A1D5PG80
names: Subcellular Location Annotation
messages: Nucleus

9031:ITIH2
gene id: 9031:ITIH2
uniprot id: B3VE14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9031:LMBRD1
gene id: 9031:LMBRD1
uniprot id: Q5ZI05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family. LMBRD1 subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). May play a role in mediating and regulating the internalization of the insulin receptor (By similarity).
messages: Lysosome membrane

9031:SLC46A1
gene id: 9031:SLC46A1
uniprot id: F1NJ67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. SLC46A family.
messages: Cell membrane
messages: Cytoplasm
messages: Endosome membrane
messages: Monomer.
messages: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:34040256). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:34040256). Functions at acidic pH via alternate outward- and inward-open conformation states (PubMed:34040256). Protonation of residues in the outward open state primes the protein for transport (PubMed:34040256). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (PubMed:34040256). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (PubMed:34040256). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (By similarity).
messages: Widely expressed, including brain, aorta, liver, kidney, spleen, small intestine, pancreas, ovary and testis.

9031:KBTBD8
gene id: 9031:KBTBD8
uniprot id: A0A1D5PX74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9031:MAP1LC3A
gene id: 9031:MAP1LC3A
uniprot id: A0A1D5PFR7
names: Similarity
messages: Belongs to the ATG8 family.

9031:NIPSNAP2
gene id: 9031:NIPSNAP2
uniprot id: Q5ZJ12
names: Similarity
messages: Belongs to the NipSnap family.

9031:TMEM50B
gene id: 9031:TMEM50B
uniprot id: A0A1L1RX69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9031:FDFT1
gene id: 9031:FDFT1
uniprot id: Q5ZKW1
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

9031:LOC107054634
gene id: 9031:LOC107054634
uniprot id: A0A8V0Z7L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9031:FOXM1
gene id: 9031:FOXM1
uniprot id: Q5ZL11
names: Subcellular Location Annotation
messages: Nucleus

9031:SLC45A1
gene id: 9031:SLC45A1
uniprot id: A0A8V0Z8Q9
uniprot id: A0A8V0ZEM3
names: Subcellular Location Annotation
messages: Membrane

9031:UCKL1
gene id: 9031:UCKL1
uniprot id: A0A8V1A018
uniprot id: F1NB19
names: Similarity
messages: Belongs to the uridine kinase family.

9031:CNR1
gene id: 9031:CNR1
uniprot id: A0A8V0X9W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids. Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues. Signaling typically involves reduction in cyclic AMP.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

9031:SEC23A
gene id: 9031:SEC23A
uniprot id: A0A1D5P0E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9031:RAD54B
gene id: 9031:RAD54B
uniprot id: Q9DG67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Involved in DNA repair and mitotic recombination.
messages: Nucleus

9031:PXN
gene id: 9031:PXN
uniprot id: P49024
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of v-CRK.
messages: Interacts (via LD motif 4) with PARVA/PARVIN and ILK.
messages: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

9031:LRP8
gene id: 9031:LRP8
uniprot id: Q98931
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the LDLR family.
messages: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. Also binds alpha2-macroglobulin. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity).
messages: Homooligomer. Interacts with VLDLR. Reelin associates with two or more receptor molecules (By similarity). Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17 (By similarity). Interacts with PCSK9. Interacts with MDK; this interaction is calcium dependent (By similarity). Interacts with CLU (By similarity).
messages: Mainly in brain.
messages: Membrane
messages: O-glycosylated.
messages: Tyrosine phosphorylated upon apoE binding.

9031:SLC26A9
gene id: 9031:SLC26A9
uniprot id: E1C2B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.
messages: Membrane

9031:CETN1
gene id: 9031:CETN1
uniprot id: F1NM71
names: Similarity
messages: Belongs to the centrin family.

9031:IDUA
gene id: 9031:IDUA
uniprot id: Q5F366
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

9031:SLIT3
gene id: 9031:SLIT3
uniprot id: A0A8V0Y2C2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:GCNT1
gene id: 9031:GCNT1
uniprot id: F1NU59
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9031:RPN2
gene id: 9031:RPN2
uniprot id: Q5ZM80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9031:IGHMBP2
gene id: 9031:IGHMBP2
uniprot id: E1BY42
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

9031:GGPS1
gene id: 9031:GGPS1
uniprot id: A0A1D5NWX3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9031:THBS4
gene id: 9031:THBS4
uniprot id: F1NBP0
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ARHGAP26
gene id: 9031:ARHGAP26
uniprot id: A0A1D5PAP4
uniprot id: Q5ZMW5
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to the C-terminus of PTK2/FAK1.
messages: Detected in embryonic brain and liver, and at low levels in embryonic eye, heart, lung, intestine and skeletal muscle.
messages: GTPase-activating protein for RHOA and CDC42.
messages: cytoskeleton
messages: focal adhesion

9031:YES1
gene id: 9031:YES1
uniprot id: P09324
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylation at Tyr-424 maintains enzyme activity.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis.
messages: Palmitoylation at Cys-3 promotes membrane localization.
messages: centrosome
messages: cytosol

9031:ZFP36L1
gene id: 9031:ZFP36L1
uniprot id: S5TQ07
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9031:NR2F1
gene id: 9031:NR2F1
uniprot id: F1NJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:LOC769317
gene id: 9031:LOC769317
uniprot id: A0A1L1RTV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:CCN2
gene id: 9031:CCN2
uniprot id: Q98TQ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:ASAH1
gene id: 9031:ASAH1
uniprot id: Q5ZK58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid ceramidase family.
messages: Lysosome

9031:SNRPD3
gene id: 9031:SNRPD3
uniprot id: Q5ZL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

9031:SCT
gene id: 9031:SCT
uniprot id: Q58G85
names: Similarity
messages: Belongs to the glucagon family.

9031:MAFG
gene id: 9031:MAFG
uniprot id: Q90889
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Maf subfamily.
messages: Homodimer or heterodimer.
messages: Nucleus
messages: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).
messages: Sumoylation at Lys-14 is required for active transcriptional repression.

9031:TXNL4B
gene id: 9031:TXNL4B
uniprot id: E1C0A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9031:LOC100859616
gene id: 9031:LOC100859616
uniprot id: A0A1D5PSK7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:NDUFB5
gene id: 9031:NDUFB5
uniprot id: Q5ZK61
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.

9031:TMEM230
gene id: 9031:TMEM230
uniprot id: Q5ZLH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9031:TNKS2
gene id: 9031:TNKS2
uniprot id: Q800E0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:CAV1
gene id: 9031:CAV1
uniprot id: P35431
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).
messages: Membrane raft
messages: Phosphorylated on tyrosine residue(s).
messages: caveola

9031:NKX3-2
gene id: 9031:NKX3-2
uniprot id: Q98TG7
names: Subcellular Location Annotation
messages: Nucleus

9031:HIC1
gene id: 9031:HIC1
uniprot id: Q90850
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
messages: Binds specifically to the gamma F-1-binding motif of the gamma F-crystallin promoter. May have a regulatory role in sclerotome specification and/or differentiation. Isoform 2 functions as a transcriptional repressor in lens cells.
messages: In the embryo of stage 11, expressed predominantly in the head mesenchyme surrounding the brain and in the paraxial mesoderm. Highly expressed in presomitic mesoderm and then over the entire epithelial somite. During somitic differentiation, expression becomes restricted to the sclerotome. In the developing lens, expression is most active at the beginning of lens fiber cell differentiation.
messages: Interacts with CtBP.
messages: Isoform 1 is highly expressed in kidney and lung. Expression of isoform 2 is higher in the lens, retina and stomach, and extremely low in heart, muscle, kidney and lung. Isoform 3 is weakly expressed in heart, kidney and lens.
messages: Nucleus

9031:MCM8
gene id: 9031:MCM8
uniprot id: I0IUP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MCM family.
messages: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.
messages: Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9.
messages: Nucleus

9031:SUPT4H1
gene id: 9031:SUPT4H1
uniprot id: E1C4X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

9031:FAM49B
gene id: 9031:FAM49B
uniprot id: A0A1D5PZ00
uniprot id: A0A3Q2TTC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

9031:RPS7
gene id: 9031:RPS7
uniprot id: F1NN16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: centrosome

9031:BGLAP
gene id: 9031:BGLAP
uniprot id: A0A1D5PRL0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9031:LOC100857512
gene id: 9031:LOC100857512
uniprot id: R4GFB4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:GPR6
gene id: 9031:GPR6
uniprot id: A0A8E7PDW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:PPME1
gene id: 9031:PPME1
uniprot id: Q5ZHM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

9031:DISP3
gene id: 9031:DISP3
uniprot id: B9U3F2
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the patched family.
messages: Cytoplasmic vesicle membrane
messages: Down-regulated by thyroid hormone T3 in retinal ganglion layers during the embryonic development (PubMed:19179482).
messages: Endoplasmic reticulum membrane
messages: Expressed in retina, hippocampus and cerebellum (PubMed:19179482). Expressed in the ganglion and bipolar cells of the inner and outer nuclear layers of the retina and in Purkinje cells (at protein level) (PubMed:19179482). Expressed strongly in brain and retina, weakly in testis and bone marrow (PubMed:19179482).
messages: Nucleus membrane
messages: Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol (PubMed:19179482). Involved in intracellular lipid droplet formation (PubMed:19179482). May contribute to cholesterol homeostasis in neuronal cells (PubMed:19179482).
messages: The SSD (sterol-sensing) domain is necessary for the increase in cellular cholesterol uptake (PubMed:19179482).

9031:RFNG
gene id: 9031:RFNG
uniprot id: A0A140T8F8
uniprot id: O12972
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Detected at stage 15 in the presumptive dorsal-limb ectoderm. At stages 16-18 expression is restricted to the dorsal side with higher concentration at the dorsoventral boundary and later in the AER. Expression remains restricted to the dorsal ectoderm and the AER until stages 22-24 when it starts to fade in the dorsal ectoderm, but remains in the AER until the last stage examined (27).
messages: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Plays an important role in limb outgrowth, it directs the formation and positioning of the apical ectodermal ridge (AER), one of the key organizer centers of vertebrate limb development (PubMed:9121551, PubMed:9121552).
messages: Golgi apparatus membrane
messages: Membrane

9031:SMDT1
gene id: 9031:SMDT1
uniprot id: F1NJF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9031:TYRP1
gene id: 9031:TYRP1
uniprot id: F1NXQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane
messages: Membrane

9031:MTRF1
gene id: 9031:MTRF1
uniprot id: E1BXF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9031:KCNJ11
gene id: 9031:KCNJ11
uniprot id: F1NBC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9031:ADAMTS14
gene id: 9031:ADAMTS14
uniprot id: A0A8V0ZDY6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:SMIM15
gene id: 9031:SMIM15
uniprot id: Q5F409
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9031:ORC6
gene id: 9031:ORC6
uniprot id: A0A8V0ZNY5
uniprot id: A0A8V0ZXR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9031:OSBPL11
gene id: 9031:OSBPL11
uniprot id: A0A8V0ZEV4
names: Similarity
messages: Belongs to the OSBP family.

9031:ARL3
gene id: 9031:ARL3
uniprot id: F1N9A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9031:DDX17
gene id: 9031:DDX17
uniprot id: A0A1D5PD32
names: Similarity
messages: Belongs to the DEAD box helicase family.

9031:ZNF706
gene id: 9031:ZNF706
uniprot id: Q5ZMM5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal.

9031:ABCC1
gene id: 9031:ABCC1
uniprot id: Q5F364
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide and other xenobiotics. Hydrolyzes ATP with low efficiency. Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (By similarity). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (By similarity).

9031:NPHS2
gene id: 9031:NPHS2
uniprot id: F1P2B2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9031:DNAJA1
gene id: 9031:DNAJA1
uniprot id: Q5ZJV3
names: Subcellular Location Annotation
messages: Membrane

9031:PLA2G1B
gene id: 9031:PLA2G1B
uniprot id: B8QN52
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9031:HNF1A
gene id: 9031:HNF1A
uniprot id: A0A1L1RPG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9031:COQ8A
gene id: 9031:COQ8A
uniprot id: F1NGM2
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9031:EDNRA
gene id: 9031:EDNRA
uniprot id: O73739
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9031:JMJD4
gene id: 9031:JMJD4
uniprot id: Q5ZHV5
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1.
messages: Cytoplasm

9031:AP1S2
gene id: 9031:AP1S2
uniprot id: A0A8V0XBT5
uniprot id: Q5ZKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9031:SH3GLB1
gene id: 9031:SH3GLB1
uniprot id: A0A8V0ZT96
uniprot id: Q5ZIR1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Homodimer, and heterodimer with SH3GLB2. Binds BAX. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1 (By similarity).
messages: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity).
messages: Mitochondrion outer membrane

9031:MON2
gene id: 9031:MON2
uniprot id: A0A8V0YIJ1
names: Similarity
messages: Belongs to the MON2 family.

9031:HDAC3
gene id: 9031:HDAC3
uniprot id: P56520
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Cytoplasm
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Also functions as deacetylase for non-histone targets. In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively.
messages: Nucleus

9031:NDUFB8
gene id: 9031:NDUFB8
uniprot id: Q5ZJW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:EPN2
gene id: 9031:EPN2
uniprot id: A0A3Q2U2K2
uniprot id: A0A3Q2UI02
uniprot id: Q5ZMF7
names: Similarity
messages: Belongs to the epsin family.

9031:SYNGR3
gene id: 9031:SYNGR3
uniprot id: Q5ZLN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9031:STIM2
gene id: 9031:STIM2
uniprot id: A0A8V0YEH4
names: Subcellular Location Annotation
messages: Membrane

9031:CACNB4
gene id: 9031:CACNB4
uniprot id: B6IDG5
uniprot id: B6IDG6
uniprot id: Q804I5
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9031:IL1B
gene id: 9031:IL1B
uniprot id: O73909
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9031:CPNE4
gene id: 9031:CPNE4
uniprot id: A0A1D5PNI0
names: Similarity
messages: Belongs to the copine family.

9031:EBF2
gene id: 9031:EBF2
uniprot id: E1C814
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9031:SPARC
gene id: 9031:SPARC
uniprot id: P36377
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity).
messages: Belongs to the SPARC family.
messages: Detected in aorta, skeletal muscle, calvarium, vertebra, anterior limb, kidney, heart, brain, skin and lung.
messages: basement membrane

9031:ERBB2
gene id: 9031:ERBB2
uniprot id: Q2EJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9031:PRPH2
gene id: 9031:PRPH2
uniprot id: O42281
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRPH2/ROM1 family.
messages: Homodimer; disulfide-linked.
messages: May be involved in the morphogenesis of retina outer segment disks and the development and maintenance of the retina ultrastructure.
messages: Membrane

9031:CRYBB2
gene id: 9031:CRYBB2
uniprot id: Q6QIF4
uniprot id: Q6QIF5
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9031:ELOVL3
gene id: 9031:ELOVL3
uniprot id: E7E8G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

9031:ENO1
gene id: 9031:ENO1
uniprot id: P51913
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Binds two Mg(2+) per subunit. Required for catalysis and for stabilizing the dimer.
messages: Cytoplasm
messages: Homodimer.

9031:CTDSPL
gene id: 9031:CTDSPL
uniprot id: Q9PTJ6
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per monomer.
messages: Monomer (By similarity). Interacts with LDB1.
messages: Nucleus
messages: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity).

9031:TMEM254
gene id: 9031:TMEM254
uniprot id: E1BZD7
names: Subcellular Location Annotation
messages: Membrane

9031:CASP3
gene id: 9031:CASP3
uniprot id: O93417
names: Similarity
messages: Belongs to the peptidase C14A family.

9031:CRYBA1
gene id: 9031:CRYBA1
uniprot id: A0A8V1AK21
uniprot id: P10042
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9031:IL15
gene id: 9031:IL15
uniprot id: Q9W756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9031:IRF9
gene id: 9031:IRF9
uniprot id: Q90WI0
names: Subcellular Location Annotation
messages: Nucleus

9031:SLC25A5
gene id: 9031:SLC25A5
uniprot id: A0A1D5PCU1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9031:QSOX1
gene id: 9031:QSOX1
uniprot id: Q8JGM4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
messages: Golgi apparatus membrane
messages: N-glycosylated. O-glycosylated on Thr and Ser residues.
messages: Secreted

9031:EPHA5
gene id: 9031:EPHA5
uniprot id: F1NSE6
names: Subcellular Location Annotation
messages: Membrane

9031:AVPR1B
gene id: 9031:AVPR1B
uniprot id: Q90YN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

9031:COMP
gene id: 9031:COMP
uniprot id: A0A3Q2UFV6
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:LOC422214
gene id: 9031:LOC422214
uniprot id: Q5ZKR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By simi…
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA.
messages: Cytoplasm
messages: Nucleus

9031:SLC35F1
gene id: 9031:SLC35F1
uniprot id: A0A3Q2TW83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9031:WDR12
gene id: 9031:WDR12
uniprot id: A0A8V0ZWS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9031:TFAP2D
gene id: 9031:TFAP2D
uniprot id: B5LEQ3
names: Similarity
messages: Belongs to the AP-2 family.

9031:SNX10
gene id: 9031:SNX10
uniprot id: F1NMH3
uniprot id: Q5ZIF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9031:PGPEP1
gene id: 9031:PGPEP1
uniprot id: A0A8V1ADW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

9031:NTF3
gene id: 9031:NTF3
uniprot id: A0A3Q2U804
uniprot id: P25433
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NGF-beta family.
messages: In the embryo, the expression peak at E4.5 and decreases at later stages of development.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9031:OCA2
gene id: 9031:OCA2
uniprot id: A0A8V0XEN3
names: Subcellular Location Annotation
messages: Membrane

9031:ELAVL1
gene id: 9031:ELAVL1
uniprot id: Q9PW24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm

9031:MAD2L2
gene id: 9031:MAD2L2
uniprot id: Q4KWZ6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (By similarity). Through transcriptional regulation may play a role in epithelial-mesenchymal transdifferentiation.
messages: Chromosome
messages: Cytoplasm
messages: Homooligomer. Interacts with REV1. Interacts with FZR1 (in complex with the anaphase promoting complex APC). May interact with CDC20 (By similarity). Heterodimer with REV3L. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta. Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7. Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C-terminus.
messages: Nucleus
messages: spindle

9031:CDCA7L
gene id: 9031:CDCA7L
uniprot id: Q5F343
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:PKN3
gene id: 9031:PKN3
uniprot id: A0A3Q3B2F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

9031:DCPS
gene id: 9031:DCPS
uniprot id: A0A8V0ZXK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9031:APEH
gene id: 9031:APEH
uniprot id: Q5ZJB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.

9031:CCNL2
gene id: 9031:CCNL2
uniprot id: Q5ZJP9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).
messages: Involved in pre-mRNA splicing.
messages: Nucleus speckle
messages: nucleoplasm

9031:DDX5
gene id: 9031:DDX5
uniprot id: A0A3S5ZPN3
uniprot id: Q9W744
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9031:NSG1
gene id: 9031:NSG1
uniprot id: Q8QFP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSG family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi stack membrane
messages: Late endosome membrane
messages: Lysosome lumen
messages: Membrane
messages: Plays a role in the recycling mechanism in neurons of multiple receptors and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway.
messages: Recycling endosome membrane
messages: dendrite
messages: multivesicular body membrane
messages: trans-Golgi network membrane

9031:SP3
gene id: 9031:SP3
uniprot id: Q90WR8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-541 also control transcriptional activity.
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Interacts with HDAC1 and HDAC2; the interaction deacetylates SP3 and regulates its transcriptional activity (By similarity). Interacts with v-Jun.
messages: Nucleus
messages: PML body
messages: Sumoylation represses transcriptional activity. Lys-541 is the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Alternate sumoylation and acetylation at Lys-541 also control transcriptional activity (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription.

9031:DYNC1I2
gene id: 9031:DYNC1I2
uniprot id: Q5ZK94
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9031:MPP6
gene id: 9031:MPP6
uniprot id: A0A8V0XCJ9
names: Similarity
messages: Belongs to the MAGUK family.

9031:LCN15
gene id: 9031:LCN15
uniprot id: Q8UWH4
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9031:SLC16A7
gene id: 9031:SLC16A7
uniprot id: F1NVU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9031:FAM163A
gene id: 9031:FAM163A
uniprot id: E1BS52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9031:EIF3J
gene id: 9031:EIF3J
uniprot id: A0A8V0YNQ1
uniprot id: Q5ZKA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

9031:APLN
gene id: 9031:APLN
uniprot id: A0A8V0YQB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apelin family.
messages: extracellular space

9031:CSNK1A1
gene id: 9031:CSNK1A1
uniprot id: F1NL64
uniprot id: P67962
uniprot id: Q71UZ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly.
messages: Cytoplasm
messages: Nucleus speckle
messages: centrosome
messages: cilium basal body
messages: kinetochore
messages: spindle

9031:ASMT
gene id: 9031:ASMT
uniprot id: Q92056
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
messages: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
messages: Expressed in pineal gland and retina.
messages: Homodimer.

9031:ALDOB
gene id: 9031:ALDOB
uniprot id: P07341
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Homotetramer.
messages: In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
messages: centriolar satellite

9031:DMRT2
gene id: 9031:DMRT2
uniprot id: A0A8V0YI81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9031:NBN
gene id: 9031:NBN
uniprot id: Q9DE07
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity (PubMed:12422221). The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis (PubMed:12422221). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (By similarity). RAD50 may be required to bind DNA ends and hold them in close proximity (By similarity). NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions (By similarity). It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX (By similarity). NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation (By similarity). NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints (By similarity). The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability (By similarity). Forms a complex with RBBP8 to link DNA double-strand break sensing to resection (By similarity).
messages: Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN. Interacts with RBBP8; the interaction links the role of the MRN complex in DNA double-strand break sensing to resection.
messages: Nucleus
messages: Phosphorylated by ATM in response of ionizing radiation, and such phosphorylation is responsible intra-S phase checkpoint control and telomere maintenance.
messages: The C-terminal domain contains a MRE11-binding site, and this interaction is required for the nuclear localization of the MRN complex.
messages: The EEXXXDDL motif at the C-terminus is required for the interaction with ATM and its recruitment to sites of DNA damage and promote the phosphorylation of ATM substrates, leading to the events of DNA damage response.
messages: The FHA and BRCT domains are likely to have a crucial role for both binding to histone H2AX and for relocalization of MRE11/RAD50 complex to the vicinity of DNA damage.
messages: telomere

9031:ACADSB
gene id: 9031:ACADSB
uniprot id: Q5ZK70
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9031:TOR4A
gene id: 9031:TOR4A
uniprot id: F1NLT2
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9031:NEK6
gene id: 9031:NEK6
uniprot id: Q5F3L5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:POLR3A
gene id: 9031:POLR3A
uniprot id: Q5ZL98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
messages: Nucleus

9031:HS3ST1
gene id: 9031:HS3ST1
uniprot id: E1C4I5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:ATP2B1
gene id: 9031:ATP2B1
uniprot id: Q98SH2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: By vitamin D and 1,25-dihydroxyvitamin D3, and by calcium and phosphorous deficiency.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis.
messages: Cell membrane

9031:AQP5
gene id: 9031:AQP5
uniprot id: A0A1D5P9U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9031:CLDN16
gene id: 9031:CLDN16
uniprot id: A0A8V0YPC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:MEMO1
gene id: 9031:MEMO1
uniprot id: A0A8V0Y0E4
names: Similarity
messages: Belongs to the MEMO1 family.

9031:SSRP1
gene id: 9031:SSRP1
uniprot id: A0A8V1A0V3
uniprot id: B6ZLK1
uniprot id: Q04678
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity).
messages: Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also a component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B (By similarity).
messages: Nucleus
messages: nucleolus

9031:WBP4
gene id: 9031:WBP4
uniprot id: Q5F457
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the spliceosome B complex. Associated with U2 snRNPs. Binds splicing factors SNRPB, SNRPC and SF1 (By similarity).
messages: Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.
messages: Nucleus
messages: Nucleus speckle

9031:TERT
gene id: 9031:TERT
uniprot id: Q537V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

9031:HEATR5B
gene id: 9031:HEATR5B
uniprot id: E1C8J1
names: Similarity
messages: Belongs to the HEATR5 family.

9031:LOC425470
gene id: 9031:LOC425470
uniprot id: A0A8V0ZJK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted
messages: acrosome

9031:PSMC1
gene id: 9031:PSMC1
uniprot id: Q90732
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

9031:EXOC8
gene id: 9031:EXOC8
uniprot id: Q5ZJ43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO84 family.
messages: Cell projection
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Cytoplasm
messages: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8.
messages: growth cone
messages: perinuclear region

9031:TIPIN
gene id: 9031:TIPIN
uniprot id: Q5F416
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSM3 family.
messages: Cytoplasm
messages: Interacts with TIMELESS, which impairs TIMELESS self-association.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be required for the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).

9031:NDUFA12
gene id: 9031:NDUFA12
uniprot id: D5M8S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:PPAT
gene id: 9031:PPAT
uniprot id: P28173
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9031:TLCD1
gene id: 9031:TLCD1
uniprot id: F1NZP5
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with CACNA1C in vitro; however the relevance of the interaction in vivo is unclear.
messages: Regulates the composition and fluidity of the plasma membrane (By similarity). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (By similarity). Does not appear to have any effect on LCPUFA synthesis (By similarity).
messages: Was originally proposed to be a calcium channel facilitator (PubMed:23673622). However, a more recent study shows that this protein regulates membrane phospholipid homeostasis (By similarity). Therefore, any effects on calcium flux are most likely a secondary consequence of defects in membrane composition or fluidity (By similarity).

9031:SYNM
gene id: 9031:SYNM
uniprot id: Q90662
names: Similarity
messages: Belongs to the intermediate filament family.

9031:MEF2A
gene id: 9031:MEF2A
uniprot id: A0A1D5PBY4
uniprot id: A0A8V0Z1Q2
names: Subcellular Location Annotation
messages: Nucleus

9031:C21orf91
gene id: 9031:C21orf91
uniprot id: Q9I8W6
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the EURL family.
messages: Expressed in undifferentiated retina and lens (PubMed:12815627).
messages: Plays a role in cortical progenitor cell proliferation and differentiation. May promote dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway.

9031:CCKBR
gene id: 9031:CCKBR
uniprot id: Q7T1P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:EXOC3
gene id: 9031:EXOC3
uniprot id: F1NHD9
uniprot id: Q5ZJ55
names: Similarity
messages: Belongs to the SEC6 family.

9031:B3GAT1
gene id: 9031:B3GAT1
uniprot id: A0A8V0ZXL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:FUT7
gene id: 9031:FUT7
uniprot id: Q8UWB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9031:GALNT7
gene id: 9031:GALNT7
uniprot id: A0A3Q2U9V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:PEX3
gene id: 9031:PEX3
uniprot id: E1BS88
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9031:AGTPBP1
gene id: 9031:AGTPBP1
uniprot id: R9PXP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9031:PDCD4
gene id: 9031:PDCD4
uniprot id: Q98TX3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PDCD4 family.
messages: Cytoplasm
messages: Expressed in a broad spectrum of hematopoietic organs, such as thymus and bursa. Lower levels of expression detected in the kidney.
messages: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis.
messages: Interacts with EIF4A.
messages: Nucleus
messages: Up-regulated by viral v-myb.

9031:HDLBP
gene id: 9031:HDLBP
uniprot id: E1C3A9
names: Subcellular Location Annotation
messages: Cytoplasm

9031:SOAT1
gene id: 9031:SOAT1
uniprot id: A0A1D6UPR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:GUCY2C
gene id: 9031:GUCY2C
uniprot id: E1BZE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9031:PPP4R2
gene id: 9031:PPP4R2
uniprot id: Q5ZMU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP4R2 family.
messages: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

9031:PKIA
gene id: 9031:PKIA
uniprot id: Q90641
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9031:GABRA4
gene id: 9031:GABRA4
uniprot id: A0A8V0YKW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:SLC39A10
gene id: 9031:SLC39A10
uniprot id: A0A8V0Y6T7
names: Subcellular Location Annotation
messages: Membrane

9031:LOC771456
gene id: 9031:LOC771456
uniprot id: U3NEE3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
messages: Monomer.
messages: N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles.
messages: Two different proteins belonging to two different protein families are able to mediate carnosine N-methyltransferase activity in chicken. This protein, which is not conserved in mammals, and another protein (AC F1N9S8), which is conserved from human to yeast.

9031:EPHA7
gene id: 9031:EPHA7
uniprot id: O42422
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
messages: Cell membrane
messages: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
messages: Phosphorylated.
messages: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7 (By similarity).
messages: Within the nervous system, expression is restricted to prosomeres 1 and 2 in the diencephalon and all the rhombomeres in the hindbrain during segmentation stages. Later on, a superimposed pattern appears that correlates with the formation of several axonal tracts. In the somitic mesoderm, the expression correlates with segmentation and the guidance of both neural crest and motor axons through the sclerotomes.

9031:SLC1A1
gene id: 9031:SLC1A1
uniprot id: E1C1P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9031:TRAPPC2
gene id: 9031:TRAPPC2
uniprot id: Q5ZKP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Nucleus
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: perinuclear region

9031:FOXG1
gene id: 9031:FOXG1
uniprot id: Q90964
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Can be detected in regions including primordial retina and neuroepithelium by embryonic day 2 (2dpc). At 3 dpc, expressed in the nasal retina and pigment epithelium as well as in the telencephalon, and at 7 dpc is expressed in retinal ganglion cells. Levels begin to decline from 4 dpc and almost disappear by 10 dpc.
messages: May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.
messages: Nucleus
messages: Retina and brain.

9031:TNFAIP6
gene id: 9031:TNFAIP6
uniprot id: Q155F6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CCLI5
gene id: 9031:CCLI5
uniprot id: A0A3S5ZPQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:LOC374195
gene id: 9031:LOC374195
uniprot id: A0A8V0YEP1
uniprot id: A0A8V0YMN8
names: Subcellular Location Annotation
messages: Nucleus

9031:ITGA4
gene id: 9031:ITGA4
uniprot id: A0A1D5PKL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9031:SLC47A1
gene id: 9031:SLC47A1
uniprot id: Q5ZK46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9031:UFSP2
gene id: 9031:UFSP2
uniprot id: Q5ZIF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C78 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus
messages: Thiol-dependent isopeptidase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.

9031:HBE
gene id: 9031:HBE
uniprot id: P02128
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Beta-type chain found in early embryos.
messages: Heterotetramer of two epsilon chains and two alpha chains. Hemoglobin E (Hbe) contains a alpha-A chains while hemoglobin M (Hbm) contains alpha-D chains.

9031:PPARGC1A
gene id: 9031:PPARGC1A
uniprot id: Q60GU0
names: Subcellular Location Annotation
messages: PML body

9031:HACD2
gene id: 9031:HACD2
uniprot id: Q5ZII7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:C1S
gene id: 9031:C1S
uniprot id: Q5F3N3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:MPPED1
gene id: 9031:MPPED1
uniprot id: E1C8B4
names: Similarity
messages: Belongs to the UPF0046 family.

9031:EIF4G2
gene id: 9031:EIF4G2
uniprot id: Q5KTT9
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9031:MRPL17
gene id: 9031:MRPL17
uniprot id: F1NHT8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9031:PROKR1
gene id: 9031:PROKR1
uniprot id: B9W049
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:ATIC
gene id: 9031:ATIC
uniprot id: P31335
uniprot id: Q5U784
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AMP and XMP inhibit AICAR formyltransferase activity (By similarity). AICAR formyltransferase activity is competitively inhibited by 2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfo-phenyl)-1H-pyrazol-4-ylazo]-4-sulfo-benzoic acid (326203-A) (PubMed:15355974). FAICAR cyclization is competitively inhibited by 1,5-dihydroimidazo[4,5-c][1,2,6]thiadiazin-4(3H)-one-2,2-dioxide and the corresponding nucleoside and nucleoside monophosphate (PubMed:17324932).
messages: Belongs to the PurH family.
messages: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:12501179). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:12501179). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity).
messages: Homodimer (PubMed:11323713, PubMed:12501179). Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (By similarity).
messages: The IMP cyclohydrolase activity resides in the N-terminal region.
messages: The de novo purine synthesis pathway includes 10 sequential steps, beginning with phosphoribosyl pyrophosphate and ending with inositol monophosphate (IMP), the first purin compound of the pathway.
messages: cytosol

9031:GIP
gene id: 9031:GIP
uniprot id: A1DPK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

9031:HSPB7L
gene id: 9031:HSPB7L
uniprot id: R4GM85
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

9031:SLC35E1
gene id: 9031:SLC35E1
uniprot id: F1NE93
names: Subcellular Location Annotation
messages: Membrane

9031:SBK1
gene id: 9031:SBK1
uniprot id: H9L0G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

9031:PKP4
gene id: 9031:PKP4
uniprot id: Q5ZK79
names: Similarity
messages: Belongs to the beta-catenin family.

9031:ACER2
gene id: 9031:ACER2
uniprot id: E1C990
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SPERT
gene id: 9031:SPERT
uniprot id: A1KXM5
names: Similarity
messages: Belongs to the chibby family. SPERT subfamily.

9031:CD200R1B
gene id: 9031:CD200R1B
uniprot id: Q2YHT5
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CD200R family.
messages: Expressed in peripheral blood lymphocytes (PBL) and peripheral blood mononuclear cells (PBMC).
messages: Membrane

9031:PTPN1
gene id: 9031:PTPN1
uniprot id: O13016
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
messages: Endoplasmic reticulum membrane
messages: May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity).
messages: Phosphorylated on serine and threonine residues near the N-terminus by casein kinase II (CK2).

9031:WDR1
gene id: 9031:WDR1
uniprot id: O93277
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat AIP1 family.
messages: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity).
messages: cytoskeleton

9031:NR1H3
gene id: 9031:NR1H3
uniprot id: Q8JHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9031:NUDT12
gene id: 9031:NUDT12
uniprot id: E1C2E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9031:GJA3
gene id: 9031:GJA3
uniprot id: P29415
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (By similarity). During early stages of lens development, interacts with the C-terminus of MIP (PubMed:14762116).
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Detected in eye lens.
messages: Structural component of lens fiber gap junctions (PubMed:7678009). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:7678009).
messages: gap junction

9031:CERS3
gene id: 9031:CERS3
uniprot id: F1N8P2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9031:INVS
gene id: 9031:INVS
uniprot id: Q8UVC3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds calmodulin via its IQ domains. Interacts with APC2 (By similarity).
messages: Cytoplasm
messages: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity).
messages: The D-box (destruction box) mediate the interaction with APC proteins, and may act as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: cytoskeleton

9031:SUMO1
gene id: 9031:SUMO1
uniprot id: Q8QGH2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2 (By similarity). Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

9031:RAP1B
gene id: 9031:RAP1B
uniprot id: Q5ZHX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell junction
messages: Cell membrane
messages: Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity).
messages: cytosol

9031:CHM
gene id: 9031:CHM
uniprot id: Q5ZKN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9031:CITED4
gene id: 9031:CITED4
uniprot id: Q9I8K7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as transcriptional coactivator. Enhances estrogen-dependent transactivation mediated by estrogen receptors.
messages: Belongs to the CITED family.
messages: Expressed in the pre-somitic mesoderm, mesonephric tubules, Wolfan ducts and collecting tubules of the developing urogenital system. Also expressed in the cranial sensory ganglia, pineal gland and eye.
messages: Nucleus

9031:TH
gene id: 9031:TH
uniprot id: Q9PU40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region

9031:CD164
gene id: 9031:CD164
uniprot id: Q98TQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9031:BCS1L
gene id: 9031:BCS1L
uniprot id: Q5ZI95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9031:ERGIC3
gene id: 9031:ERGIC3
uniprot id: R4GJ83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9031:AQP4
gene id: 9031:AQP4
uniprot id: Q65YQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9031:CDC20
gene id: 9031:CDC20
uniprot id: Q5ZI36
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9031:TLL1
gene id: 9031:TLL1
uniprot id: F1P398
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:DCTD
gene id: 9031:DCTD
uniprot id: Q5ZJM4
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9031:OAT
gene id: 9031:OAT
uniprot id: Q5ZJ29
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9031:UBE4A
gene id: 9031:UBE4A
uniprot id: Q5ZKF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9031:MRPL20
gene id: 9031:MRPL20
uniprot id: E1BRV2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9031:ATRNL1
gene id: 9031:ATRNL1
uniprot id: A0A3Q2UFR3
uniprot id: A0A8V0ZR22
uniprot id: A0A8V0ZWM2
uniprot id: E1BYK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:WDR45B
gene id: 9031:WDR45B
uniprot id: Q5ZL16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2.
messages: Lysosome
messages: Preautophagosomal structure
messages: The L/FRRG motif is required for recruitment to PtdIns3P.

9031:CENPH
gene id: 9031:CENPH
uniprot id: Q90ZF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-H/MCM16 family.
messages: Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for the localization of CENPC but not CENPA to the centromere. It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
messages: Component of the CENPA-HI complex, at least composed of CENPH, CENPI, CENPK, CENPL, CENPM, CENPO and CENPP. Interacts with NDC80.
messages: Nucleus
messages: kinetochore

9031:PLPP1
gene id: 9031:PLPP1
uniprot id: A0A1D5NZW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9031:OR5AP2
gene id: 9031:OR5AP2
uniprot id: A0A8V1AM68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:MAFA
gene id: 9031:MAFA
uniprot id: O42290
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Maf subfamily.
messages: First detected in the lens placode at stage 11, when the head ectoderm makes contact with the optic vesicle. The expression remains restricted to the invaginating lens placode, and subsequently to the developing lens vesicle. In 8-day old embryo, almost exclusively expressed in lens with very weak expression in brain.
messages: Forms homodimers or heterodimers. May interact (via leucine-zipper domain) with MAFB. May interact with FOS and JUN. Interacts with PCAF; this interaction impairs MAFA ubiquitination.
messages: Nucleus
messages: Transcription factor involved in transcription regulation during lens development, including that of crystallin and filensin/BFSP1 genes (PubMed:9525857). Binds to CRE-type MARE 5'-TGCTGACGTCAGCA-3' and TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequences (PubMed:12970735).

9031:AP3M1
gene id: 9031:AP3M1
uniprot id: Q5ZMP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).
messages: The AP-3 complex associates with the BLOC-1 complex.

9031:IMPG2
gene id: 9031:IMPG2
uniprot id: Q1XI86
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix.
messages: Detected in retina at 12 dpc with increased expression up to a peak at 16 dpc.
messages: Expressed in retina.
messages: Highly glycosylated (N- and O-linked carbohydrates).
messages: Photoreceptor inner segment membrane
messages: Photoreceptor outer segment membrane
messages: interphotoreceptor matrix

9031:AASDHPPT
gene id: 9031:AASDHPPT
uniprot id: R4GI82
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

9031:TTR
gene id: 9031:TTR
uniprot id: A0A1I7Q422
uniprot id: P27731
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transthyretin family.
messages: Detected in serum (at protein level). Detected in liver and choroid plexus.
messages: Homotetramer.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules.
messages: Secreted
messages: Sulfonation of the reactive cysteine Cys-33 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation.
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9031:SEPTIN9
gene id: 9031:SEPTIN9
uniprot id: A0A8V1ALX9
uniprot id: Q5F3T2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9031:ADGRD2
gene id: 9031:ADGRD2
uniprot id: A0A8V1AKD5
uniprot id: A0A8V1AM49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:GRHL1
gene id: 9031:GRHL1
uniprot id: A0A1D5NZ26
uniprot id: A0A1D5PX42
names: Subcellular Location Annotation
messages: Nucleus

9031:CHRNA6
gene id: 9031:CHRNA6
uniprot id: A0A8V0YLH7
uniprot id: P49581
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:UBE2V2
gene id: 9031:UBE2V2
uniprot id: Q5F3Z3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).
messages: Heterodimer with UBE2N.

9031:HOPX
gene id: 9031:HOPX
uniprot id: Q8JHU0
names: Function
names: Subcellular Location Annotation
messages: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. May act via an interaction with SRF, leading to modulate the expression of SRF-dependent cardiac-specific genes and cardiac development. May act as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assist in chaperone-mediated protein refolding.
messages: Cytoplasm
messages: Nucleus

9031:EPHX1L
gene id: 9031:EPHX1L
uniprot id: E1C7F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Microsome membrane

9031:TUBG1
gene id: 9031:TUBG1
uniprot id: A0A8V0ZJI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.
messages: cytoskeleton

9031:PTPRS
gene id: 9031:PTPRS
uniprot id: F1NWE3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
messages: Cell membrane
messages: Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:11865065, PubMed:17178832). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:17967490). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:17967490). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (PubMed:17967490). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (By similarity).
messages: Detected in embryonic brain, dorsal root ganglion and spinal cord (PubMed:7600997). Detected in embryonic retina (at protein level) (PubMed:11865065). Detected in embryonic brain, spinal cord, dorsal root ganglion, trigeminal ganglion, ganglia associated with the precardinal vein and vagus nerve, the inner and outer nuclear layer of the retina, limb, breast muscle, heart, gut and lung.
messages: Homodimer (PubMed:17178832). Binding to large heparan sulfate proteoglycan structures promotes oligomerization. Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (By similarity). Interacts (via Ig-like domains) with NTRK1 and NTRK3, but does not form detectable complexes with NTRK2 (PubMed:17967490, PubMed:25385546). Interacts (via extracellular domain) with the heparan sulfate proteoglycans AGRN and COL18A1 (PubMed:11865065).
messages: Perikaryon
messages: Postsynaptic density
messages: axon
messages: growth cone
messages: neuron projection
messages: synaptic vesicle membrane
messages: synaptosome

9031:GDPD1
gene id: 9031:GDPD1
uniprot id: F1NYV4
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:AWAT1
gene id: 9031:AWAT1
uniprot id: H6W8E6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ELOVL2
gene id: 9031:ELOVL2
uniprot id: E1BYE9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9031:PIGH
gene id: 9031:PIGH
uniprot id: F1P5E0
names: Similarity
messages: Belongs to the PIGH family.

9031:SNTG1
gene id: 9031:SNTG1
uniprot id: A0A1D5NVQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9031:MED24
gene id: 9031:MED24
uniprot id: Q5F3M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 24 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

9031:RSAD2
gene id: 9031:RSAD2
uniprot id: F1NLJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:DLX4
gene id: 9031:DLX4
uniprot id: A0A3B1EZB7
names: Subcellular Location Annotation
messages: Nucleus

9031:ELOVL7
gene id: 9031:ELOVL7
uniprot id: E1C102
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:CLK3
gene id: 9031:CLK3
uniprot id: F1NLR7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:SUOX
gene id: 9031:SUOX
uniprot id: A0A8V0ZUQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b5 family.
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Homodimer.
messages: Mitochondrion intermembrane space

9031:KIAA1191
gene id: 9031:KIAA1191
uniprot id: Q5F368
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth (By similarity).

9031:GOLT1A
gene id: 9031:GOLT1A
uniprot id: A0A8V1AG65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9031:TXNDC5
gene id: 9031:TXNDC5
uniprot id: Q5ZIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9031:TRPV4
gene id: 9031:TRPV4
uniprot id: A0A1D5PXA5
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP binding enhances channel sensitivity to agonists. Ca(2+)-calmodulin prevents the ATP-mediated increased sensitivity to agonists.
messages: Apical cell membrane
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily.
messages: Homotetramer (By similarity). Interacts with Ca(2+)-calmodulin (PubMed:19864432).
messages: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11081638). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:11081638). Also activated by phorbol esters (PubMed:19864432). Channel activity seems to be regulated by a calmodulin-dependent mechanism (By similarity).
messages: The ANK repeat region mediates interaction with Ca(2+)-calmodulin and ATP binding (PubMed:19864432). The ANK repeat region mediates interaction with phosphatidylinositol-4,5-bisphosphate and related phosphatidylinositides (PubMed:25256292).
messages: adherens junction

9031:TGS1
gene id: 9031:TGS1
uniprot id: Q5ZJ77
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9031:DYNLRB1
gene id: 9031:DYNLRB1
uniprot id: A0A8V0ZTZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

9031:GPT2
gene id: 9031:GPT2
uniprot id: A0A1D5PND8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9031:GSTK1
gene id: 9031:GSTK1
uniprot id: F1N9G6
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9031:ABI2
gene id: 9031:ABI2
uniprot id: A0A8V0ZLP0
uniprot id: A0A8V0ZLP7
uniprot id: A0A8V0ZU46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9031:GABRG1
gene id: 9031:GABRG1
uniprot id: Q7LZ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:KCNA2
gene id: 9031:KCNA2
uniprot id: Q7T1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane

9031:SAT1
gene id: 9031:SAT1
uniprot id: Q8AXL1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Cytoplasm
messages: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells.
messages: Homodimer.
messages: Preferentially expressed in the dorsal-temporal quadrant of the developing retina. There was a sharp increase in retinal SSAT levels during the transition stage from proliferation (7 dpc) to early differentiation (10 dpc). SSAT was found in Muller glial cells and its distribution pattern in these cells closely followed the three differentiation axis of the developing retina, with a central-dorsal-temporal preference.

9031:P2RY8
gene id: 9031:P2RY8
uniprot id: Q5ZI82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Probable receptor for purines coupled to G-proteins.

9031:ESF1
gene id: 9031:ESF1
uniprot id: Q5ZK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9031:VPS4B
gene id: 9031:VPS4B
uniprot id: Q5ZMI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9031:DMD
gene id: 9031:DMD
uniprot id: P11533
names: Function
names: Subcellular Location Annotation
messages: May play a role in anchoring the cytoskeleton to the plasma membrane.
messages: Postsynaptic cell membrane
messages: cytoskeleton
messages: sarcolemma

9031:SDR16C5
gene id: 9031:SDR16C5
uniprot id: Q5ZL32
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:ACTN1
gene id: 9031:ACTN1
uniprot id: A0A1D5P9P3
uniprot id: P05094
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-actinin family.
messages: Cell junction
messages: Cell membrane
messages: F-actin cross-linking protein is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
messages: Homodimer; antiparallel (By similarity). Interacts with PDLIM4 (via PDZ domain) (PubMed:14729062).
messages: Z line
messages: cytoskeleton
messages: ruffle

9031:CTPS2
gene id: 9031:CTPS2
uniprot id: A0A8V0X6H2
uniprot id: Q5F3Z1
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity).

9031:SLC7A7
gene id: 9031:SLC7A7
uniprot id: A0A1D5P6T2
names: Subcellular Location Annotation
messages: Membrane

9031:HIST1H111R
gene id: 9031:HIST1H111R
uniprot id: P08288
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

9031:DVL1
gene id: 9031:DVL1
uniprot id: A0A8V0ZBM6
uniprot id: A0A8V0ZBP3
names: Similarity
messages: Belongs to the DSH family.

9031:ERCC5
gene id: 9031:ERCC5
uniprot id: F1P266
uniprot id: Q4AEJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

9031:NRXN3
gene id: 9031:NRXN3
uniprot id: D0PRN3
uniprot id: D0PRN4
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neurexin family.
messages: Brain and arteries (at protein level).
messages: Membrane
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion (By similarity). Plays a role in angiogenesis.
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity).
messages: Proccessed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides (By similarity).
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform 1b.

9031:DCP1B
gene id: 9031:DCP1B
uniprot id: A0A3Q2U9U1
names: Similarity
messages: Belongs to the DCP1 family.

9031:MCHR2
gene id: 9031:MCHR2
uniprot id: B3GRU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:SMC1B
gene id: 9031:SMC1B
uniprot id: F1NX72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9031:ESRRB
gene id: 9031:ESRRB
uniprot id: A0A1D5NVI7
uniprot id: A0A1D5PDM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9031:MYO5A
gene id: 9031:MYO5A
uniprot id: Q02440
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Golgi apparatus membrane
messages: May be a homodimer, which associates with multiple calmodulin or myosin light chains.
messages: Neuronal and non-neuronal cells of the brain.
messages: Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (By similarity).

9031:LIMK1
gene id: 9031:LIMK1
uniprot id: A0A8V1ADV1
uniprot id: Q8QFP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Expressed predominantly in the brain.
messages: Nucleus
messages: Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Required for motility of the axon growth cone.
messages: cytoskeleton
messages: growth cone

9031:MCRIP1
gene id: 9031:MCRIP1
uniprot id: Q5ZIU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: May play a role in the regulation of the epithelial-mesenchymal transition.
messages: Nucleus
messages: Stress granule

9031:IL21
gene id: 9031:IL21
uniprot id: D3GGX2
uniprot id: Q58IU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9031:MBOAT1
gene id: 9031:MBOAT1
uniprot id: A0A8V0XU18
names: Subcellular Location Annotation
messages: Membrane

9031:CREG2
gene id: 9031:CREG2
uniprot id: A0A3Q2U8T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9031:THRSPB
gene id: 9031:THRSPB
uniprot id: Q6Q125
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9031:ARMC8
gene id: 9031:ARMC8
uniprot id: A0A1D5PP06
uniprot id: A0A8V0ZS10
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:SRP68
gene id: 9031:SRP68
uniprot id: Q5ZJ33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9031:OR52B2
gene id: 9031:OR52B2
uniprot id: A0A8V0XKV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:DUSP7
gene id: 9031:DUSP7
uniprot id: Q5F335
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9031:CLPS
gene id: 9031:CLPS
uniprot id: B9TY09
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9031:JAKMIP3
gene id: 9031:JAKMIP3
uniprot id: A0A8V0XBK6
names: Similarity
messages: Belongs to the JAKMIP family.

9031:PALD1
gene id: 9031:PALD1
uniprot id: Q8JHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paladin family.
messages: cytosol

9031:MINA
gene id: 9031:MINA
uniprot id: Q5ZJC5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. MINA53 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.

9031:VAMP1
gene id: 9031:VAMP1
uniprot id: A0A8V0ZMB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9031:SPTSSB
gene id: 9031:SPTSSB
uniprot id: A0A1D5PLF8
uniprot id: R4GFF4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:SMAD3
gene id: 9031:SMAD3
uniprot id: P84023
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Interacts with SARA (SMAD anchor for receptor activation); form trimers with another SMAD3 and the co-SMAD SMAD4.
messages: Nucleus
messages: Phosphorylated on serine by TGF-beta and activin type 1 receptor kinases.
messages: The MH2 domain is sufficient to carry protein nuclear export.
messages: Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) (By similarity).

9031:GPD1L
gene id: 9031:GPD1L
uniprot id: F1P0W8
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9031:FAM13A
gene id: 9031:FAM13A
uniprot id: A0A1D5PTF6
uniprot id: A0A8V0Y5P2
names: Similarity
messages: Belongs to the FAM13 family.

9031:ENO2
gene id: 9031:ENO2
uniprot id: O57391
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Expressed in the brain and, to much less but significant extents, in the pituitary and adrenal glands.
messages: Homodimer.
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.

9031:HNRNPDL
gene id: 9031:HNRNPDL
uniprot id: Q5ZI72
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Binds DNA and RNA (By similarity).
messages: Cytoplasm
messages: Nucleus

9031:APLP2
gene id: 9031:APLP2
uniprot id: F1P0A7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:REXO4
gene id: 9031:REXO4
uniprot id: A0A8V1AHV0
names: Similarity
messages: Belongs to the REXO4 family.

9031:FAM133B
gene id: 9031:FAM133B
uniprot id: Q5ZLM8
names: Similarity
messages: Belongs to the FAM133 family.

9031:ADAM10
gene id: 9031:ADAM10
uniprot id: Q5F3N4
uniprot id: Q5F458
uniprot id: Q8QFX0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:BUD13
gene id: 9031:BUD13
uniprot id: Q5ZIJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC26 family.
messages: Involved in pre-mRNA splicing as component of the activated spliceosome.
messages: Nucleus
messages: Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed of at least 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Component of the minor spliceosome, which splices U12-type introns (By similarity).

9031:NFE2L1
gene id: 9031:NFE2L1
uniprot id: Q5ZL67
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. CNC subfamily.
messages: CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses. Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response. Activates or represses expression of target genes, depending on the context (By similarity). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess (By similarity). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (By similarity).
messages: Cleaved at Leu-104 following retrotranslocation, releasing the protein from the endoplasmic reticulum membrane and forming the transcription factor NRF1 that translocates into the nucleus.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (By similarity).
messages: Interacts (via the bZIP domain) with small MAF protein (MAFF, MAFG or MAFK); required for binding to antioxidant response elements (AREs) on DNA.
messages: Nucleus
messages: The cholesterol recognition/amino acid consensus (CRAC) region directly binds cholesterol, as well as campesterol and 27-hydroxycholesterol. Has much lower affinity for epicholesterol.

9031:PEX13
gene id: 9031:PEX13
uniprot id: E1C0C4
names: Similarity
messages: Belongs to the peroxin-13 family.

9031:ORC3
gene id: 9031:ORC3
uniprot id: Q5ZJG6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

9031:ERC1
gene id: 9031:ERC1
uniprot id: E1BQR7
names: Subcellular Location Annotation
messages: Cytoplasm

9031:LOC415661
gene id: 9031:LOC415661
uniprot id: F1N9C1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:ADCK1
gene id: 9031:ADCK1
uniprot id: A0A1D5PGE9
uniprot id: Q5ZMT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (By similarity). The action of this enzyme is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable).
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Secreted

9031:SYNJ2BP
gene id: 9031:SYNJ2BP
uniprot id: F1P042
names: Similarity
messages: Belongs to the DeSI family.

9031:HNRNPK
gene id: 9031:HNRNPK
uniprot id: E1C453
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm

9031:SLC46A3
gene id: 9031:SLC46A3
uniprot id: F1P383
uniprot id: Q5F4B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. SLC46A family.
messages: Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (By similarity). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (By similarity).
messages: Lysosome membrane
messages: Membrane

9031:VCAN
gene id: 9031:VCAN
uniprot id: Q90953
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Disappears after the cartilage development.
messages: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
messages: Prechondrogenic condensation area of developing limb buds.
messages: extracellular matrix
messages: interphotoreceptor matrix
messages: photoreceptor outer segment

9031:TRPV1
gene id: 9031:TRPV1
uniprot id: Q8QFN9
names: Subcellular Location Annotation
messages: Membrane

9031:IL10
gene id: 9031:IL10
uniprot id: B6RCP7
uniprot id: Q6A2H4
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IL-10 family.
messages: By lipopolysaccharide (LPS) in white blood cells, liver and spleen 3 hours after treatment. Decreases to basal levels 8 hours after treatment. By primary infection with E.acervulina and E.tenella.
messages: Chickens susceptible to E.maxima infection show higher constitutive and post-infection levels in spleen and higher post-infection levels in small intestine than infection-resistant animals.
messages: Expressed predominantly in bursa of Fabricius and cecal tonsils with low levels in thymus, liver and lung.
messages: Expression is detected as early as embryonic day 12. Higher expression in spleen of post-hatch chickens than embryos. Gradual increase in expression in the spleen which peaks by day 7 post-hatch.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Immune regulatory cytokine.
messages: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
messages: Secreted

9031:ENTPD8
gene id: 9031:ENTPD8
uniprot id: O93295
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDA1/CD39 NTPase family.
messages: Ca(2+) or Mg(2+). Has lower efficiency with Mg(2+).
messages: Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside ATPases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides.
messages: Cell membrane
messages: N-glycosylated.

9031:SCARB2
gene id: 9031:SCARB2
uniprot id: E1BRR6
names: Similarity
messages: Belongs to the CD36 family.

9031:ST6GALNAC4
gene id: 9031:ST6GALNAC4
uniprot id: Q704X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:TIMP3
gene id: 9031:TIMP3
uniprot id: P26652
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.
messages: extracellular matrix

9031:GNAI1
gene id: 9031:GNAI1
uniprot id: P50146
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity).
messages: Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Part of a spindle orientation complex. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG1. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG2. GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins (By similarity).
messages: Membrane
messages: Myristoylation at Gly-2 is required for membrane anchoring before palmitoylation.
messages: Nucleus
messages: Palmitoylation at Cys-3 varies with membrane lipid composition.
messages: cell cortex
messages: centrosome

9031:PDHA2
gene id: 9031:PDHA2
uniprot id: A0A1D5PEH3
uniprot id: Q5F426
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9031:QTRT2
gene id: 9031:QTRT2
uniprot id: Q5ZM96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9031:RRP12
gene id: 9031:RRP12
uniprot id: Q5ZKD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP12 family.
messages: Nucleus membrane
messages: nucleolus

9031:FUNDC1
gene id: 9031:FUNDC1
uniprot id: E1BWM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9031:ARF4
gene id: 9031:ARF4
uniprot id: Q5ZKR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9031:PRNP
gene id: 9031:PRNP
uniprot id: P27177
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the prion family.
messages: Cell membrane
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
messages: Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.
messages: Spinal cord and brain.

9031:TMEM178B
gene id: 9031:TMEM178B
uniprot id: R4GIP1
names: Similarity
messages: Belongs to the TMEM178 family.

9031:PLA2G4A
gene id: 9031:PLA2G4A
uniprot id: P49147
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Activated by phosphorylation on a serine residue.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
messages: Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).

9031:NDEL1
gene id: 9031:NDEL1
uniprot id: Q5ZKH4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: Phosphorylated in mitosis.
messages: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts.
messages: centrosome
messages: cytoskeleton
messages: spindle

9031:PRSS2
gene id: 9031:PRSS2
uniprot id: Q90629
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: High levels are seen in the pancreas while lower levels are found in the liver, spleen and thymus.
messages: extracellular space

9031:NMU
gene id: 9031:NMU
uniprot id: A0A1D5PLD5
uniprot id: F1NEH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9031:GUCA1B
gene id: 9031:GUCA1B
uniprot id: P79881
names: Function
names: Miscellaneous
names: Subunit
names: Tissue Specificity
messages: Binds three calcium ions.
messages: Retina and pineal gland.
messages: Stimulates synthesis of cGMP in photoreceptors. Thought to mediate Ca(2+)-sensitive regulation of retinal guanylyl cyclase (GC), a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).
messages: Undergoes dimerization at low calcium ions concentration, while the presence of calcium ions inhibits its dimerization. Dimerization correlates with its ability to activate GC.

9031:TSPAN6
gene id: 9031:TSPAN6
uniprot id: E1C857
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:TNFRSF11B
gene id: 9031:TNFRSF11B
uniprot id: A0A3Q2U211
uniprot id: Q4F9K2
names: Caution
names: Function
names: Subunit
messages: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PRPH2L
gene id: 9031:PRPH2L
uniprot id: O42282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9031:ITGA8
gene id: 9031:ITGA8
uniprot id: P26009
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the integrin alpha chain family.
messages: Cell membrane
messages: Expressed in developing tectum (at protein level).
messages: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.
messages: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
messages: Membrane
messages: Prominently expressed on axons and on cells in contact with basal laminae in embryos.

9031:MYH15
gene id: 9031:MYH15
uniprot id: F1NM49
uniprot id: Q9IBD4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:NXPH2
gene id: 9031:NXPH2
uniprot id: R4GG19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9031:MAOA
gene id: 9031:MAOA
uniprot id: Q5F4B5
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9031:UBA2
gene id: 9031:UBA2
uniprot id: Q5ZKH7
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9031:CSNK2A1
gene id: 9031:CSNK2A1
uniprot id: P21868
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
messages: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (By similarity). Plays an important role in the circadian clock function by phosphorylating BMAL1 (By similarity).
messages: Nucleus
messages: Tetramer composed of an alpha chain, an alpha' and two beta chains. Interacts with RNPS1 (By similarity).

9031:PTPRA
gene id: 9031:PTPRA
uniprot id: Q91969
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9031:GDF9
gene id: 9031:GDF9
uniprot id: Q6Q247
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9031:PLD1
gene id: 9031:PLD1
uniprot id: A0A8V0YUI0
uniprot id: E1BVP2
names: Similarity
messages: Belongs to the phospholipase D family.

9031:TUBGCP5
gene id: 9031:TUBGCP5
uniprot id: A0A8V0XBG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9031:GALNT1
gene id: 9031:GALNT1
uniprot id: Q5ZJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:HDDC2
gene id: 9031:HDDC2
uniprot id: A0A1L1RPZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

9031:POMGNT2
gene id: 9031:POMGNT2
uniprot id: Q5NDE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity).

9031:KCND2
gene id: 9031:KCND2
uniprot id: E1BS72
uniprot id: Q8UW33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9031:KIF5B
gene id: 9031:KIF5B
uniprot id: E1C3A1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:LGALS1A
gene id: 9031:LGALS1A
uniprot id: P07583
names: Function
names: Subunit
names: Tissue Specificity
messages: (Microbial infection) Interacts with newcastle disease virus protein HN; this interaction inhibits viral adsorption rather than internalization.
messages: Homodimer; disulfide-linked.
messages: Mainly in the intestine (adult), mainly in the skin (embryo).
messages: This protein binds beta-galactoside. May participate in host antiviral defense through specific interaction with glycans on the viral envelope glycoproteins.

9031:BCLAF1
gene id: 9031:BCLAF1
uniprot id: A0A1D5NWG1
uniprot id: A0A1D5PC74
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9031:APLNR
gene id: 9031:APLNR
uniprot id: E1C968
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:PGC
gene id: 9031:PGC
uniprot id: Q9PWK1
names: Similarity
messages: Belongs to the peptidase A1 family.

9031:CCDC85C
gene id: 9031:CCDC85C
uniprot id: A0A8V0YP57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9031:LOC427439
gene id: 9031:LOC427439
uniprot id: F1NJ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9031:KLHL9
gene id: 9031:KLHL9
uniprot id: Q5ZLD3
names: Function
names: Subunit
messages: Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB (By similarity).
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).

9031:AES
gene id: 9031:AES
uniprot id: A0A8V1A7N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9031:SUB1
gene id: 9031:SUB1
uniprot id: Q5ZK63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity).
messages: Nucleus

9031:DUSP12
gene id: 9031:DUSP12
uniprot id: F1N842
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9031:ADCYAP1R1
gene id: 9031:ADCYAP1R1
uniprot id: A0A8V1A3X2
uniprot id: A5YMQ0
names: Subcellular Location Annotation
messages: Membrane

9031:TF
gene id: 9031:TF
uniprot id: P02789
names: Allergen
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transferrin family.
messages: Causes an allergic reaction in human.
messages: Different forms of hen transferrin are distinguished by their carbohydrate composition. Ovotransferrin and embryo serum transferrin but not adult serum transferrin, have bisecting N-acetylglucosamine. Transferrin secreted by embryo hepatocytes in primary culture is marked by the presence of (alpha1-6) fucosylation of the core N-acetylglucosamine. Serum transferrins also differ in the number of attached neuraminic acid residues. In both embryo forms, sialylation occurs on the Man (alpha 1-3)-linked antennae.
messages: Expressed in the magnum of the oviduct (at protein level).
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels.
messages: Up-regulated by dietary stress. Increased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens (at protein level).

9031:LOC121106434
gene id: 9031:LOC121106434
uniprot id: R4GFI6
names: Subcellular Location Annotation
messages: Membrane

9031:DTNBP1
gene id: 9031:DTNBP1
uniprot id: Q5ZKM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dysbindin family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth (By similarity).
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Endosome membrane
messages: Melanosome membrane
messages: Nucleus
messages: Postsynaptic density
messages: synaptic vesicle membrane

9031:HTR1D
gene id: 9031:HTR1D
uniprot id: E1BZQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:WNT5B
gene id: 9031:WNT5B
uniprot id: F1NMK6
uniprot id: Q3L255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:NAGPA
gene id: 9031:NAGPA
uniprot id: A0A8V0Z753
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PDE6H
gene id: 9031:PDE6H
uniprot id: Q802E3
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9031:GABRR3
gene id: 9031:GABRR3
uniprot id: A0A8V0XW83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:AvBD4
gene id: 9031:AvBD4
uniprot id: Q6GXJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis.
messages: Secreted
messages: Strong expression in the bone marrow and testis. Widely expressed. Weak expression in the ovarian stroma, but not expressed in the ovarian follicles.

9031:ACTR5
gene id: 9031:ACTR5
uniprot id: Q5ZJA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP5 subfamily.
messages: Component of the chromatin remodeling INO80 complex.
messages: Nucleus
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9031:KPNA6
gene id: 9031:KPNA6
uniprot id: A0A8V0YV14
uniprot id: F7B5S0
uniprot id: Q5ZJZ0
names: Similarity
messages: Belongs to the importin alpha family.

9031:ANKH
gene id: 9031:ANKH
uniprot id: Q5EEJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9031:CASP18
gene id: 9031:CASP18
uniprot id: Q4JQQ0
names: Similarity
messages: Belongs to the peptidase C14A family.

9031:BTBD10
gene id: 9031:BTBD10
uniprot id: E1C8S4
uniprot id: R4GI02
names: Subcellular Location Annotation
messages: Cytoplasm

9031:SCD5
gene id: 9031:SCD5
uniprot id: A0A1L1RYA9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9031:CRABP1
gene id: 9031:CRABP1
uniprot id: B0FLN8
uniprot id: P40220
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9031:MAN1C1
gene id: 9031:MAN1C1
uniprot id: F1P0Z9
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9031:CITED2
gene id: 9031:CITED2
uniprot id: Q9DDW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9031:HEXDCL
gene id: 9031:HEXDCL
uniprot id: F1NB63
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

9031:CDX1
gene id: 9031:CDX1
uniprot id: Q9DEB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus
messages: Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1. Binds to the PRKD1 promoter. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.

9031:EPN3
gene id: 9031:EPN3
uniprot id: F1NZR2
names: Similarity
messages: Belongs to the epsin family.

9031:RNF4
gene id: 9031:RNF4
uniprot id: Q5ZMI1
names: Subcellular Location Annotation
messages: Nucleus

9031:OTX2
gene id: 9031:OTX2
uniprot id: Q6E236
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9031:GFOD1
gene id: 9031:GFOD1
uniprot id: E1BYY1
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9031:PQLC2
gene id: 9031:PQLC2
uniprot id: Q5ZJX0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.
messages: Belongs to the laat-1 family.
messages: Lysosome membrane
messages: The di-leucine motif mediates lysosomal localization.

9031:CALB1
gene id: 9031:CALB1
uniprot id: P04354
names: Domain
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Highly abundant in supporting cells. Also present in hair cells.
messages: This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

9031:FZD2
gene id: 9031:FZD2
uniprot id: Q6WJ01
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:C12orf75
gene id: 9031:C12orf75
uniprot id: P0C915
names: Similarity
messages: Belongs to the OCC1 family.

9031:NR1H4
gene id: 9031:NR1H4
uniprot id: Q8JHU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus

9031:PTGDS
gene id: 9031:PTGDS
uniprot id: Q8QFM7
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9031:KCNK9
gene id: 9031:KCNK9
uniprot id: A0A1D5PDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9031:ABCB1
gene id: 9031:ABCB1
uniprot id: O93437
names: Subcellular Location Annotation
messages: Membrane

9031:NUP188
gene id: 9031:NUP188
uniprot id: Q5F3Q0
names: Subcellular Location Annotation
messages: nuclear pore complex

9031:UBE2K
gene id: 9031:UBE2K
uniprot id: Q5ZIL3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:CCNK
gene id: 9031:CCNK
uniprot id: Q5ZL28
names: Similarity
messages: Belongs to the cyclin family.

9031:ADAMTS15
gene id: 9031:ADAMTS15
uniprot id: E1BX45
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:SYN3
gene id: 9031:SYN3
uniprot id: A0A1D5PMP8
names: Similarity
messages: Belongs to the synapsin family.

9031:RAB3B
gene id: 9031:RAB3B
uniprot id: E1C8J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9031:CD28
gene id: 9031:CD28
uniprot id: P31043
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Monomer.
messages: Possibly involved in T-cell activation.

9031:GJC2
gene id: 9031:GJC2
uniprot id: E1BQP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:YY2
gene id: 9031:YY2
uniprot id: Q5ZMN5
names: Similarity
messages: Belongs to the YY transcription factor family.

9031:IGF2BP1
gene id: 9031:IGF2BP1
uniprot id: O42254
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM IMP/VICKZ family.
messages: Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Associates with the cytoskeleton, predominantly with actin filament bundles and occasionally with microtubules. In a heterologous system, interacts with ELAVL1, DHX9 and HNRNPU.
messages: Cytoplasm
messages: Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute to transcript binding. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules. KH3 and KH4 mediate association with the cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only KH2 NES is XPO1-dependent. Both NES may be redundant, since individual in vitro mutations do not affect subcellular location of the full length protein.
messages: Expressed in neurons and embryonic fibroblasts (at protein level).
messages: Nucleus
messages: P-body
messages: Phosphorylated by SRC at Tyr-396. This residue is involved in ACTB mRNA binding, its phosphorylation impairs association with ACTB mRNA and hence abolishes translational repression. Phosphorylation occurs in close proximity to filopodia and in the growth cones of differentiated neuroglioblastoma cells.
messages: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation in polarized cells, a crucial process for cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves by a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The ribonucleoparticle (RNP) thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, IGF2BP1 prevents beta-actin mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated by SRC. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. The monomeric ACTB protein then assembles into the subcortical actin cytoskeleton, which pushes the leading edge onwards. Binds MYC mRNA. Binding to MYC mRNA is enhanced by m6A-modification of the CRD (By similarity). Promotes the directed movement of cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphoryl…
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9031:FBXO46
gene id: 9031:FBXO46
uniprot id: A0A8V0XV29
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9031:ATP6V0C
gene id: 9031:ATP6V0C
uniprot id: Q5ZJ19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9031:C1GALT1
gene id: 9031:C1GALT1
uniprot id: Q5F3G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Homodimer; disulfide-linked.
messages: Membrane

9031:PRKDC
gene id: 9031:PRKDC
uniprot id: Q8QGX4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated at two clusters, the T2609 cluster and the S2056 cluster. Autophosphorylated on Ser-2055, Thr-2609, Thr-2638 and Thr-2647. Ser-2055 and Thr-2609 are DNA damage-inducible phosphorylation sites (inducible with ionizing radiation, IR) dephosphorylated by PPP5C (By similarity). Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair (By similarity). Autophosphorylation in trans within DNA-PK complexes loaded on DNA ends leads to the dissociation of PRKDC from DNA and the transition into the short-range NHEJ complex (By similarity). Autophosphorylation of the T2609 cluster is required for hematopoietic development and protein synthesis in erythrocytes precursors (By similarity).
messages: Belongs to the PI3/PI4-kinase family.
messages: DNA-PK is a heterotrimer of PRKDC and the Ku dimer (composed of XRCC6/Ku70 and XRCC5/Ku86). Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF. Additional component of the NHEJ complex includes PAXX. Following autophosphorylation, PRKDC dissociates from DNA.
messages: Nucleus
messages: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ. Act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (By similarity). Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (By similarity).
messages: nucleolus

9031:ARGLU1
gene id: 9031:ARGLU1
uniprot id: Q5ZL35
names: Similarity
messages: Belongs to the UPF0430 family.

9031:LBR
gene id: 9031:LBR
uniprot id: A0A8V0YPJ6
uniprot id: A0A8V0YXW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9031:ZBED1
gene id: 9031:ZBED1
uniprot id: A0A3Q2UG84
names: Subcellular Location Annotation
messages: Nucleus

9031:FSCN2
gene id: 9031:FSCN2
uniprot id: D5LHI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9031:MAP3K5
gene id: 9031:MAP3K5
uniprot id: A0A1D5PTJ8
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9031:ATP5L
gene id: 9031:ATP5L
uniprot id: F1NIL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9031:B4GALT7
gene id: 9031:B4GALT7
uniprot id: Q2HPN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:CHRNA2
gene id: 9031:CHRNA2
uniprot id: P09480
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily.
messages: Cell membrane
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.
messages: Postsynaptic cell membrane

9031:VPS35
gene id: 9031:VPS35
uniprot id: Q5ZL51
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9031:IRAK1BP1
gene id: 9031:IRAK1BP1
uniprot id: A0A8V0XET7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9031:GABARAPL1
gene id: 9031:GABARAPL1
uniprot id: E1C2J6
names: Similarity
messages: Belongs to the ATG8 family.

9031:SNRPGP15
gene id: 9031:SNRPGP15
uniprot id: E1C8V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9031:CDC37
gene id: 9031:CDC37
uniprot id: O57476
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC37 family.
messages: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
messages: Cytoplasm
messages: Forms a complex with Hsp90.

9031:AP1M1
gene id: 9031:AP1M1
uniprot id: Q5ZMG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

9031:IFNW1
gene id: 9031:IFNW1
uniprot id: Q90873
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:PKD2L2
gene id: 9031:PKD2L2
uniprot id: F1NE51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

9031:LIF
gene id: 9031:LIF
uniprot id: A0A8V0X6M3
names: Function
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

9031:ST8SIA5
gene id: 9031:ST8SIA5
uniprot id: A0A1D5PIR8
uniprot id: A0A3Q2TZK0
uniprot id: Q6ZX98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:UHRF2
gene id: 9031:UHRF2
uniprot id: A0A8V0YPN2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

9031:RPL10A
gene id: 9031:RPL10A
uniprot id: F6SU35
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9031:SBNO2
gene id: 9031:SBNO2
uniprot id: A0A1D5NY24
uniprot id: A0A1D5PRM4
uniprot id: A0A8V1A6R4
names: Similarity
messages: Belongs to the SBNO family.

9031:RBM6
gene id: 9031:RBM6
uniprot id: A0A1D5PAD2
uniprot id: Q5F3M4
names: Subcellular Location Annotation
messages: Nucleus

9031:DPH2
gene id: 9031:DPH2
uniprot id: Q5ZKI2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).

9031:TM7SF3
gene id: 9031:TM7SF3
uniprot id: A0A1D5PTV5
names: Subcellular Location Annotation
messages: Membrane

9031:PLPPR4
gene id: 9031:PLPPR4
uniprot id: R4GL67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9031:HTR1E
gene id: 9031:HTR1E
uniprot id: E1BS44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:PREPL
gene id: 9031:PREPL
uniprot id: A0A8V0ZER9
uniprot id: F1NG64
uniprot id: Q5ZKL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9A family.
messages: Homodimer.
messages: Serine peptidase whose precise substrate specificity remains unclear (By similarity). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (By similarity). May play a role in the regulation of synaptic vesicle exocytosis (By similarity).
messages: cytosol

9031:SMARCD1
gene id: 9031:SMARCD1
uniprot id: A0A8V0ZUV5
names: Similarity
messages: Belongs to the SMARCD family.

9031:CENPX
gene id: 9031:CENPX
uniprot id: A0A1D5PAJ6
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

9031:XDH
gene id: 9031:XDH
uniprot id: P47990
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters per subunit.
messages: Cytoplasm
messages: Detected in liver (at protein level).
messages: Homodimer.
messages: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
messages: Peroxisome

9031:SPP2
gene id: 9031:SPP2
uniprot id: Q91982
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Secreted

9031:ANKHD1
gene id: 9031:ANKHD1
uniprot id: E1BXT7
names: Subcellular Location Annotation
messages: Cytoplasm

9031:NSUN2
gene id: 9031:NSUN2
uniprot id: Q5ZLV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.
messages: Cytoplasm
messages: Mitochondrion
messages: RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs). Also mediates C(5)-methylation of mitochondrial tRNAs. Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay. Cytosine C(5)-methylation of mRNAs also regulates mRNA export. Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
messages: extracellular exosome
messages: nucleolus
messages: spindle

9031:DAG1
gene id: 9031:DAG1
uniprot id: A4VAR9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9031:MGAT5
gene id: 9031:MGAT5
uniprot id: F1NEL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9031:CHRNA4
gene id: 9031:CHRNA4
uniprot id: P09482
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.
messages: Cell membrane
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.
messages: Postsynaptic cell membrane

9031:HIST1H46L2
gene id: 9031:HIST1H46L2
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:NPY5R
gene id: 9031:NPY5R
uniprot id: F1NWY5
uniprot id: Q8QFM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

9031:MEAF6
gene id: 9031:MEAF6
uniprot id: A0A8V0YX04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

9031:STRN3
gene id: 9031:STRN3
uniprot id: A0A1D5PD87
uniprot id: A0A1D5PSR0
uniprot id: A0A3Q2TY03
uniprot id: A0A3Q2UHY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9031:ANO10
gene id: 9031:ANO10
uniprot id: A0A1D5P0N6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:CNP3
gene id: 9031:CNP3
uniprot id: A9CDT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9031:KIAA1429
gene id: 9031:KIAA1429
uniprot id: A0A1D5PLG6
names: Similarity
messages: Belongs to the vir family.

9031:ATP6V0E1
gene id: 9031:ATP6V0E1
uniprot id: Q5ZJC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9031:GABPA
gene id: 9031:GABPA
uniprot id: Q5ZJ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:HSP90AA1
gene id: 9031:HSP90AA1
uniprot id: P11501
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Melanosome
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from Hsp90 which acquires an open conformation for the next cycle.
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.

9031:GDF2
gene id: 9031:GDF2
uniprot id: P34822
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Appears to regulate cell differentiation within the neural tube. May regulate the differentiation of cell types along the dorsoventral axis of the neural tube, acting in conjunction with distinct ventralizing signals from the notochord and floor plate. Controls the cell differentiation in the neural tube in several ways: (1) promotes the differentiation of cell types that derive from the dorsal neural tube. (2) ensures that the dorsal neural tube is refractory to ventralizing species from the notochord. (3) can diffuse and influence the fate of cells in more ventral regions of the neural tube.
messages: Belongs to the TGF-beta family.
messages: Expressed selectively in the dorsal neural tube. Lower levels seen in kidney and myotomal cells.
messages: Homodimer; disulfide-linked.
messages: Is not expressed in neural cells at stages before neural tube closure. Is expressed at high levels in the dorsal third of the neural tube, beginning at the time of neural tube closure, but not by ventral neural cells or by nonneural cells. Dorsal restriction persists in the spinal cord at stages after the onset of neuronal differentiation. At later stages of spinal development, is restricted to the dorsomedial region of the spinal cord, including but not confined to the roof plate.
messages: Secreted

9031:SNTB1
gene id: 9031:SNTB1
uniprot id: Q5ZKZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9031:PRKAR1A
gene id: 9031:PRKAR1A
uniprot id: Q5ZM91
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules (By similarity).
messages: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain but is not phosphorylated. The physiological significance of phosphorylations by other kinases is unclear (By similarity).

9031:SRF
gene id: 9031:SRF
uniprot id: F6MF48
names: Subcellular Location Annotation
messages: Nucleus

9031:GRB10
gene id: 9031:GRB10
uniprot id: A0A1D5P405
uniprot id: A0A8V0X5W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9031:DUSP3
gene id: 9031:DUSP3
uniprot id: A0A1D5PI23
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9031:CENPA
gene id: 9031:CENPA
uniprot id: A5HUM4
uniprot id: Q6XXM1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. CENPA modulates the DNA-binding characteristics of nucleosomes so that protruding DNA ends have higher flexibility than in nucleosomes containing conventional histone H3.
messages: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:14563550). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:15870271).
messages: Nucleus
messages: Present in all interphase cells with a punctate pattern in the nucleus. Aligned along the metaphase plate in metaphase cells and becomes concentrated at the poles in anaphase cells (at protein level).
messages: centromere

9031:APOB
gene id: 9031:APOB
uniprot id: Q197X2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GHRHR-LR
gene id: 9031:GHRHR-LR
uniprot id: B3F053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9031:DPYSL2
gene id: 9031:DPYSL2
uniprot id: Q71SG2
uniprot id: Q90635
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Detected in the developing chick nervous system.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1 (By similarity).
messages: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity).

9031:ATP23
gene id: 9031:ATP23
uniprot id: E1C7J8
names: Similarity
messages: Belongs to the peptidase M76 family.

9031:CTNNA2
gene id: 9031:CTNNA2
uniprot id: A0A8V0Z4L2
uniprot id: P30997
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the neural tube, dorsal root glanglia, spinal nerves and myotome at 4 dpc. Expressed in neuronal and glial cell populations as detected at 10 dpc (at protein level).
messages: Interacts with CDH1 and CDH2.
messages: Mainly in the nervous system (at protein level).
messages: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system.
messages: Membrane
messages: Nucleus
messages: adherens junction
messages: axon
messages: cytoskeleton

9031:OLA1
gene id: 9031:OLA1
uniprot id: Q5ZM25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

9031:CD3D
gene id: 9031:CD3D
uniprot id: Q90768
names: Subcellular Location Annotation
messages: Membrane

9031:MARK1
gene id: 9031:MARK1
uniprot id: A0A8V0YVT9
uniprot id: A0A8V0Z157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9031:XKRX
gene id: 9031:XKRX
uniprot id: A0A8V0Z3W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9031:HEBP1
gene id: 9031:HEBP1
uniprot id: Q5ZMB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEBP family.
messages: Cytoplasm
messages: Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
messages: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity).
messages: Monomer.

9031:ACTA2
gene id: 9031:ACTA2
uniprot id: F1P476
uniprot id: P08023
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9031:FGF7
gene id: 9031:FGF7
uniprot id: Q5KRA4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:DUSP5
gene id: 9031:DUSP5
uniprot id: A0A1D5P5S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9031:EIF3E
gene id: 9031:EIF3E
uniprot id: Q5ZLA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Nucleus

9031:PFN3
gene id: 9031:PFN3
uniprot id: E1BXG1
names: Similarity
messages: Belongs to the profilin family.

9031:CCR9
gene id: 9031:CCR9
uniprot id: Q702H3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:PIK3CG
gene id: 9031:PIK3CG
uniprot id: E1C093
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:GUCA2B
gene id: 9031:GUCA2B
uniprot id: R4GIC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9031:ATXN1L
gene id: 9031:ATXN1L
uniprot id: R4GIP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9031:DDB1
gene id: 9031:DDB1
uniprot id: Q805F9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of the UV-DDB complex which includes DDB1 and DDB2 (By similarity). Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, CUL4A or CUL4B and RBX1, and a substrate receptor, such as CRBN (PubMed:25043012). DDB1 may recruit specific substrate targeting subunits to the DCX complex. These substrate targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (By similarity). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (Probable). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (By similarity). May play a role in the regulation of the circadian clock (By similarity).
messages: The core of the protein consists of three WD40 beta-propeller domains.

9031:OCLN
gene id: 9031:OCLN
uniprot id: Q91049
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Interacts with TJP1 and TJP3.
messages: Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in lung and liver. Expressed at a lower level in brain.
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with ZO-1.
messages: Phosphorylated.
messages: The C-terminal is cytoplasmic and is important for interaction with ZO-1. Necessary for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction. The second extracellular domain may also be implicated in the permeability barrier function of the tight junction.
messages: tight junction

9031:INPP5A
gene id: 9031:INPP5A
uniprot id: A0A1D5PX66
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

9031:CCDC61
gene id: 9031:CCDC61
uniprot id: Q5ZJ07
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC61 family.
messages: Forms homodimers (via head domain).
messages: Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Plays a non-essential role in ciliogenesis.
messages: The N-terminal 3D structure (head domain) resembles that of NHEJ1/XLF, PAXX, SASS6 and XRCC4.
messages: The coiled-coil domain is involved in microtubule-binding.
messages: centriolar satellite
messages: centrosome
messages: cilium basal body

9031:CRHR2
gene id: 9031:CRHR2
uniprot id: Q7ZZZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

9031:SLC41A3
gene id: 9031:SLC41A3
uniprot id: A0A1D5P4N1
uniprot id: A0A1D5PG02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9031:SBK3
gene id: 9031:SBK3
uniprot id: A0A8V0XN68
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:TRIM59
gene id: 9031:TRIM59
uniprot id: Q5ZMD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Endoplasmic reticulum membrane
messages: Interacts with ECSIT.
messages: May serve as a multifunctional regulator for innate immune signaling pathways.

9031:RPS28
gene id: 9031:RPS28
uniprot id: A0A3Q2U825
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

9031:E2F8
gene id: 9031:E2F8
uniprot id: A0A8V0ZGY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9031:FBXO9
gene id: 9031:FBXO9
uniprot id: Q5ZIN8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9).
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling.

9031:HOXC8
gene id: 9031:HOXC8
uniprot id: Q9YH13
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
messages: Transcripts are present at 3.5 dpc in the somitic cells, which give rise to the dorsal dermis by 5 dpc, and at 6.5 dpc to 8.5 dpc in the dorsal dermal and epidermal cells during the first stages of feather morphogenesis.

9031:ZDHHC8
gene id: 9031:ZDHHC8
uniprot id: Q2THW3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:MC2R
gene id: 9031:MC2R
uniprot id: O57317
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

9031:CCL20
gene id: 9031:CCL20
uniprot id: Q8QG55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:CACNA2D2
gene id: 9031:CACNA2D2
uniprot id: A0A1D5PIN9
uniprot id: A0A8V1AHM4
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9031:LOC101748661
gene id: 9031:LOC101748661
uniprot id: A0A8V0XXQ2
names: Subcellular Location Annotation
messages: Membrane

9031:CCNG2
gene id: 9031:CCNG2
uniprot id: A0A8V0XWX0
names: Similarity
messages: Belongs to the cyclin family.

9031:RNF182
gene id: 9031:RNF182
uniprot id: E1BZ35
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9031:PLK1
gene id: 9031:PLK1
uniprot id: Q5ZJ36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

9031:C12orf49
gene id: 9031:C12orf49
uniprot id: Q5ZJE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.

9031:SLC35A3
gene id: 9031:SLC35A3
uniprot id: A0A8V0ZX33
uniprot id: A0A8V1A2H8
uniprot id: F1NZW9
uniprot id: Q5ZJS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:GNB4
gene id: 9031:GNB4
uniprot id: E1BW98
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9031:LBX2
gene id: 9031:LBX2
uniprot id: Q29ZM6
names: Subcellular Location Annotation
messages: Nucleus

9031:TBX22
gene id: 9031:TBX22
uniprot id: Q8AYE5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:ABCA1
gene id: 9031:ABCA1
uniprot id: Q8UVV4
names: Subcellular Location Annotation
messages: Membrane

9031:ALG6
gene id: 9031:ALG6
uniprot id: Q802T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

9031:RPRD1B
gene id: 9031:RPRD1B
uniprot id: Q5F4B4
names: Similarity
messages: Belongs to the UPF0400 (RTT103) family.

9031:OLIG2
gene id: 9031:OLIG2
uniprot id: Q90XB3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for oligodendrocyte and motor neuron specification in the spinal cord.

9031:CCDC126
gene id: 9031:CCDC126
uniprot id: E1BS45
names: Subcellular Location Annotation
messages: Secreted

9031:CDC14A
gene id: 9031:CDC14A
uniprot id: D5K9Y5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9031:NSA2
gene id: 9031:NSA2
uniprot id: Q5ZMH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9031:TFDP3
gene id: 9031:TFDP3
uniprot id: A0A8V0YW27
uniprot id: A0A8V0YWF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9031:XPO5
gene id: 9031:XPO5
uniprot id: F1NBL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9031:NT5DC1
gene id: 9031:NT5DC1
uniprot id: E1C3Z6
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

9031:ADPRH
gene id: 9031:ADPRH
uniprot id: Q5ZMJ1
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9031:AXIN2
gene id: 9031:AXIN2
uniprot id: Q6TLV9
names: Subcellular Location Annotation
messages: Cytoplasm

9031:AKTIP
gene id: 9031:AKTIP
uniprot id: Q5ZJJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.
messages: May function to promote vesicle trafficking and/or fusion. May also regulate apoptosis (By similarity).

9031:C4BPS
gene id: 9031:C4BPS
uniprot id: Q4AEJ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:FAM18B1
gene id: 9031:FAM18B1
uniprot id: Q5ZJJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9031:CWC15
gene id: 9031:CWC15
uniprot id: E1C8V6
names: Similarity
messages: Belongs to the CWC15 family.

9031:ACYP1
gene id: 9031:ACYP1
uniprot id: P07032
names: Similarity
names: Tissue Specificity
messages: Belongs to the acylphosphatase family.
messages: Organ-common type isozyme is found in many different tissues.

9031:MYB
gene id: 9031:MYB
uniprot id: P01103
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
messages: Nucleus
messages: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
messages: Truncation of either the N- or C-terminal of C-Myb leads to increased transformation and transactivation potential.

9031:PDLIM1
gene id: 9031:PDLIM1
uniprot id: A0A1D5NU14
uniprot id: E1C852
names: Subcellular Location Annotation
messages: Z line

9031:LIFR
gene id: 9031:LIFR
uniprot id: Q8QFQ7
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9031:UMPS
gene id: 9031:UMPS
uniprot id: Q5ZMR2
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9031:CSE1L
gene id: 9031:CSE1L
uniprot id: E1BV44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9031:OLFML3
gene id: 9031:OLFML3
uniprot id: Q25C36
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Expression first appears at Hensen's node and subsequently in the axial and paraxial mesoderm. When the neural tube closes, strong expression is transiently found in the roof plate region from the rostral midbrain to the hindbrain.
messages: Secreted
messages: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity).

9031:EN2
gene id: 9031:EN2
uniprot id: Q05917
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the engrailed homeobox family.
messages: Nucleus

9031:MRPS6
gene id: 9031:MRPS6
uniprot id: Q5ZIJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

9031:CXCL13L2
gene id: 9031:CXCL13L2
uniprot id: F1NBL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9031:OLFR6
gene id: 9031:OLFR6
uniprot id: P37072
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Odorant receptor.

9031:GLYR1
gene id: 9031:GLYR1
uniprot id: Q5ZLS7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome
messages: Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression. Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes.
messages: Homotetramere. Binds to mononucleosomes.
messages: In the dehydrogenase domain, the conserved NAD(P)H-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity. However, since the active site is not conserved, the dehydrogenase domain seems to serve as a catalytically inert oligomerization module.
messages: Nucleus
messages: The A.T hook DNA-binding domain is required for the interaction with MAPK14.
messages: The PWWP domain is a H3 reader and strongly binds DNA.

9031:FGF10
gene id: 9031:FGF10
uniprot id: O42407
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:MIF
gene id: 9031:MIF
uniprot id: Q02960
uniprot id: Q90ZI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIF family.
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus
messages: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).
messages: Secreted
messages: centrosome

9031:PPP4R3A
gene id: 9031:PPP4R3A
uniprot id: A0A8V0YYA4
names: Similarity
messages: Belongs to the SMEK family.

9031:NDUFAB1
gene id: 9031:NDUFAB1
uniprot id: E1C4C0
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9031:MGP
gene id: 9031:MGP
uniprot id: O42413
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: In 16-day-old embryo, expressed at high level in the sternum and tibia, at low level in skeletal muscle, heart and gizzard. Not present in skin, liver and brain.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9031:PDE6D
gene id: 9031:PDE6D
uniprot id: A0A1D5P2A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9031:RTFDC1
gene id: 9031:RTFDC1
uniprot id: F1NU37
names: Similarity
messages: Belongs to the rtf2 family.

9031:PCNP
gene id: 9031:PCNP
uniprot id: Q5ZLV1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

9031:EPGN
gene id: 9031:EPGN
uniprot id: Q5EG71
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Promotes the growth of epithelial cells.

9031:CCNB3
gene id: 9031:CCNB3
uniprot id: P39963
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Could be involved at the G2/M (mitosis or meiosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
messages: Interacts with the CDK1 and CDK2 protein kinases.
messages: Nucleus
messages: The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: Ubiquitinated, leading to its degradation.

9031:LOC100859586
gene id: 9031:LOC100859586
uniprot id: A0A1D5PAN7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:HIST1H111L
gene id: 9031:HIST1H111L
uniprot id: P08287
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

9031:DPM2
gene id: 9031:DPM2
uniprot id: Q5ZK98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9031:PKLR
gene id: 9031:PKLR
uniprot id: F1NW43
uniprot id: P00548
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate.
messages: Belongs to the pyruvate kinase family.
messages: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP.
messages: Homotetramer.
messages: This activity is regulated by glucose levels.

9031:DLC1
gene id: 9031:DLC1
uniprot id: A0A1D5PBM9
uniprot id: A0A1D5PEQ5
uniprot id: F1P3K3
names: Subcellular Location Annotation
messages: Cytoplasm

9031:PELO
gene id: 9031:PELO
uniprot id: Q5ZK01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.
messages: Component of the Pelota-HBS1L complex, also named Dom34-Hbs1 complex, composed of PELO and HBS1L.
messages: Cytoplasm

9031:SLC8A3
gene id: 9031:SLC8A3
uniprot id: F1P023
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9031:UBAP2
gene id: 9031:UBAP2
uniprot id: E1C5S0
names: Subcellular Location Annotation
messages: Cytoplasm

9031:MPC1L
gene id: 9031:MPC1L
uniprot id: Q5ZJW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9031:FZD4
gene id: 9031:FZD4
uniprot id: Q9IA05
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Expressed in optic cup at stages 10-19 and in nephric tubules from stage 10 to 20 and more. Expression in interdigital space begins at stage 20.
messages: Expressed in the developing kidney, interdigital spaces and optic cup.
messages: Interacts (via FZ domain) with TSKU; TSKU competes with WNT2B for binding to FZD4, inhibiting Wnt signaling and repressing peripheral eye development.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Receptor for Wnt proteins (By similarity). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase (By similarity). Both pathways seem to involve interactions with G-proteins (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity).
messages: The FZ domain is involved in binding with Wnt ligands.

9031:NOG
gene id: 9031:NOG
uniprot id: O93525
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: At stage 8 (4-6 somites) expressed in two prominent regions, the notochord and the one posterior to Hensen node. At stage 14 (20 somites) expressed in the lateral border of the segmental plate. As the somite stage proceeds, detected in the lateral and medial portion of a young and old somite respectively and is also localized in the notochord and the roof plate of the neural tube.
messages: Belongs to the noggin family.
messages: By sonic ectopic hedgehog.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling. Controls somitogenesis by sequestering the BMP-4 activity which in turn differentiates distinct subtypes of the mesoderm along the mediolateral axis.
messages: Secreted

9031:ABCG4
gene id: 9031:ABCG4
uniprot id: A0A8V0ZWB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9031:POLR2H
gene id: 9031:POLR2H
uniprot id: A0A1D5PCT2
uniprot id: A0A1D5PED8
uniprot id: E1BSD8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9031:CPM
gene id: 9031:CPM
uniprot id: E1C041
names: Similarity
messages: Belongs to the peptidase M14 family.

9031:SCOC
gene id: 9031:SCOC
uniprot id: B0LHV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

9031:COX10
gene id: 9031:COX10
uniprot id: Q5ZJY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

9031:LITAF
gene id: 9031:LITAF
uniprot id: Q8QGW7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Nucleus
messages: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines.
messages: The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.

9031:MOXD1
gene id: 9031:MOXD1
uniprot id: Q98ST7
names: Cofactor
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Endoplasmic reticulum membrane
messages: Expressed in neural crest at all developmental stages, and in developing somite and myotome.

9031:FMN1
gene id: 9031:FMN1
uniprot id: Q05858
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the formin homology family. Cappuccino subfamily.
messages: In the developing limb bud, the protein is expressed in the apical ectodermal ridge and the mesenchymal compartment, predominantly in the posterior region. During kidney morphogenesis, expression is initially restricted to the epithelial compartment of the pronephros and mesonephros.
messages: Is important for morphogenesis of limb and kidney and may be involved in determining dorsoventral neural tube polarity and motor neuron induction. It may also have a function in differentiated cells or be involved in maintaining specific differentiated states.
messages: Nucleus
messages: Present in the adult brain, kidney, brain, heart and intestine and throughout the embryo.

9031:CDH22
gene id: 9031:CDH22
uniprot id: E1C3A7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

9031:ZER1
gene id: 9031:ZER1
uniprot id: F1NI66
names: Similarity
messages: Belongs to the zyg-11 family.

9031:TMEM45L
gene id: 9031:TMEM45L
uniprot id: E1BSJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9031:FAM60A
gene id: 9031:FAM60A
uniprot id: Q5ZJV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SINHCAF family.
messages: Component of the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L, HDAC1. Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1.
messages: Nucleus
messages: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway. Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells and is essential to maintain the complex on chromatin.

9031:G2E3
gene id: 9031:G2E3
uniprot id: Q5F4A1
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
messages: Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity (By similarity).
messages: nucleolus

9031:SULT
gene id: 9031:SULT
uniprot id: O57338
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:GFRA4
gene id: 9031:GFRA4
uniprot id: O93512
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Expressed in muscle, kidney, brain, stomach and intestine at 6 dpc. Levels increase in the brain from 6 dpc to 18 dpc, and decrease in muscle and intestine. Levels in the kidney remain constant. From 10 dpc, expression also found in heart, lung, skin and liver. Levels in the liver increase dramatically at 18 dpc. At 18 dpc, highest expression found in kidney and brain. In the embryonic central nervous system, the spinal cord expressed the highest levels. Lower levels found in the medulla oblongata, pons, cerebellum and midbrain, and very low levels in the forebrain.
messages: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).

9031:MGAT4C
gene id: 9031:MGAT4C
uniprot id: Q9DGD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 54 family.
messages: Glycosyltransferase that catalyzes the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (also named 'GnT-VI' activity). May also participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans by catalyzing the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans.
messages: Golgi apparatus membrane
messages: Highly expressed in oviduct, spleen, lung and colon.

9031:DNAL4
gene id: 9031:DNAL4
uniprot id: Q5ZHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9031:CDC37L1
gene id: 9031:CDC37L1
uniprot id: F1NH83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9031:RBM10
gene id: 9031:RBM10
uniprot id: Q5F3M2
names: Subcellular Location Annotation
messages: Nucleus

9031:USP4
gene id: 9031:USP4
uniprot id: Q5ZKD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Nucleus

9031:LOC100859381
gene id: 9031:LOC100859381
uniprot id: F1NDD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:EIF4EBP2
gene id: 9031:EIF4EBP2
uniprot id: A0A1L1RKV7
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9031:LOC101747503
gene id: 9031:LOC101747503
uniprot id: Q2AB82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9031:GRIA4
gene id: 9031:GRIA4
uniprot id: Q90729
uniprot id: Q90858
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:CATH3
gene id: 9031:CATH3
uniprot id: C4PFJ9
uniprot id: Q2IAL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cathelicidin family.
messages: Detected in bone marrow, liver and lung.
messages: May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).
messages: Membrane
messages: Secreted

9031:CASP6
gene id: 9031:CASP6
uniprot id: A0A1D5PPP7
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C14A family.
messages: Cysteine protease that plays essential roles in programmed cell death, development and innate immunity (PubMed:11953316). Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein lamin-A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed:11953316). Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution (PubMed:11953316). Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity. PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis (By similarity).
messages: Cytoplasm
messages: During activation, the N-terminal prodomain is removed by cleavage (By similarity). Concomitantly, double cleavage gives rise to a large 18-kDa and a small 11-kDa subunit (By similarity). The two large and two small subunits then assemble to form the active CASP6 complex (By similarity). Intramolecular cleavage at Asp-191 is a prerequisite for CASP6 self-activation (By similarity).
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit.
messages: Nucleus
messages: The N-terminal disordered prodomain is required to prevent self-activation.
messages: The Tri-arginine exosite is required to recruit substrates for hydrolysis.
messages: Undergoes helix-strand structural transitions upon substrate-binding: the 130's region interconverts between an inactive helical state and the canonically active strand state. Other caspases rest constitutively in the strand conformation before and after substrate-binding.
messages: Widely expressed.

9031:LOC771069
gene id: 9031:LOC771069
uniprot id: E1BUD0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:TEC
gene id: 9031:TEC
uniprot id: F1NZY8
uniprot id: Q5ZI88
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9031:SFT2D1
gene id: 9031:SFT2D1
uniprot id: F1NPE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9031:PHOSPHO2
gene id: 9031:PHOSPHO2
uniprot id: E1C2Z3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9031:CHMP5
gene id: 9031:CHMP5
uniprot id: E1BSI4
names: Similarity
messages: Belongs to the SNF7 family.

9031:ASL1
gene id: 9031:ASL1
uniprot id: P02521
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles.
messages: Eye lens.
messages: Homotetramer.
messages: The N-terminus is blocked.

9031:LOC100859819
gene id: 9031:LOC100859819
uniprot id: A0A8V1A4R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9031:CD8BP
gene id: 9031:CD8BP
uniprot id: Q90769
names: Subcellular Location Annotation
messages: Membrane

9031:OAZ1
gene id: 9031:OAZ1
uniprot id: O42148
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ODC antizyme family.
messages: Interacts with ODC1 and thereby sterically blocks ODC homodimerization.
messages: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.

9031:CCDC43
gene id: 9031:CCDC43
uniprot id: Q5ZK95
names: Similarity
messages: Belongs to the CCDC43 family.

9031:RNF5
gene id: 9031:RNF5
uniprot id: Q5ZIR9
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity).
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane
messages: The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.

9031:PLA2G4EL6
gene id: 9031:PLA2G4EL6
uniprot id: A0A8V0ZKD2
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9031:SUFU
gene id: 9031:SUFU
uniprot id: Q8QG94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Nucleus

9031:NEK8
gene id: 9031:NEK8
uniprot id: A0A3Q2UF44
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9031:NTRK3
gene id: 9031:NTRK3
uniprot id: Q91044
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Interacts with PTPRS (PubMed:17967490, PubMed:25385546).
messages: Expression occurs in the 2 dpc embryo with increasing levels later in development. In the 9 dpc embryo highest levels are found in brain and spinal cord with intermediate levels in eye, heart, gut and muscle. Low levels are found in kidney, liver, skin and yolk sac.
messages: Ligand-mediated auto-phosphorylation.
messages: Membrane
messages: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells (PubMed:8060621).
messages: The kinase domain is of 19 aa instead of 39aa in the isoform alpha-KD due to a frameshift.

9031:ENSA
gene id: 9031:ENSA
uniprot id: Q5ZIF8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A.
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).

9031:ADAM9
gene id: 9031:ADAM9
uniprot id: Q5ZJH4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PHPT1L
gene id: 9031:PHPT1L
uniprot id: A0A3Q3AHU9
names: Function
names: Similarity
messages: Belongs to the janus family.
messages: Exhibits phosphohistidine phosphatase activity.

9031:NGFR
gene id: 9031:NGFR
uniprot id: A9UGK7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PRKD1
gene id: 9031:PRKD1
uniprot id: Q5F3M9
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9031:PADI1
gene id: 9031:PADI1
uniprot id: E1C0W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Cytoplasm

9031:TGFBI
gene id: 9031:TGFBI
uniprot id: O42390
names: Subcellular Location Annotation
messages: extracellular matrix

9031:P2RY6
gene id: 9031:P2RY6
uniprot id: Q98907
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9031:PBRM1
gene id: 9031:PBRM1
uniprot id: Q90941
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex.
messages: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
messages: Nucleus

9031:RAB21
gene id: 9031:RAB21
uniprot id: A0A8V0YGN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: trans-Golgi network

9031:KIF23
gene id: 9031:KIF23
uniprot id: A0A1D5PDE8
uniprot id: A0A8V0YW62
uniprot id: A0A8V0YY58
uniprot id: Q5ZI55
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:ACTR2
gene id: 9031:ACTR2
uniprot id: P53488
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the actin family. ARP2 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
messages: Nucleus
messages: cytoskeleton

9031:CASK
gene id: 9031:CASK
uniprot id: A0A1D5PB73
names: Similarity
messages: Belongs to the MAGUK family.

9031:RGS9BP
gene id: 9031:RGS9BP
uniprot id: Q6XK22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RGS7BP/RGS9BP family.
messages: Expressed in a variety of neuronal tissues, particularly in sensory cells including inner ear hair cells, photoreceptors and dorsal root ganglion neurons.
messages: Membrane
messages: Regulator of G protein-coupled receptor (GPCR) signaling. Probably acts by regulating the activity of some 'R7' family protein (RGS6, RGS7, RGS9 and/or RGS11).

9031:TAOK3
gene id: 9031:TAOK3
uniprot id: Q9I9E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases. Inhibits basal activity of MAPK8/JNK cascade (By similarity).

9031:DNAJC3
gene id: 9031:DNAJC3
uniprot id: Q5ZI13
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: May be involved in the unfolded protein response (UPR) during ER stress.

9031:GLUL
gene id: 9031:GLUL
uniprot id: P16580
names: Activity Regulation
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Expressed in retina, brain and liver (PubMed:1356223). Little or no detectable expression in breast muscle, pancreas and spleen (PubMed:1356223).
messages: Glutamate to glutamine ratio influences catalytic activity (PubMed:19895308). At glutamate to glutamine ratios greater than 4, decarboxylase activity ceases (PubMed:19895308). In the presence of manganese, synthetase activity is limited to concentrations between 10 mM and 20 mM, whereas decarboxylase activity is not affected (PubMed:19895308). Both catalytic activities are inhibited by avidin (PubMed:19895308).
messages: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:19895308). When expressed in liver, it may be involved in detoxifying intramitochondrially generated ammonia (PubMed:4401992). Also acts as glutamate decarboxylase by catalyzing the production of 4-aminobutanoate (gamma-aminobutyric acid, GABA) in a pyridoxal phosphate-independent manner (PubMed:19895308).
messages: Homooctamer and homotetramer.
messages: In the retina, down-regulated upon application of glutamate concentrations of 15 umol/eye or higher.
messages: Mitochondrion
messages: Weakly expressed in retina on embryonic day 18, with levels increasing until day 6 after hatching and then remaining high until day 21 (at protein level).

9031:TPX2
gene id: 9031:TPX2
uniprot id: Q805A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

9031:CTSEAL
gene id: 9031:CTSEAL
uniprot id: E1C897
names: Similarity
messages: Belongs to the peptidase A1 family.

9031:ADPRHL2
gene id: 9031:ADPRHL2
uniprot id: Q5ZI51
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (By similarity). Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
messages: Belongs to the ADP-ribosylglycohydrolase family.
messages: Binds 2 magnesium ions per subunit.
messages: Chromosome
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: The protein undergoes a dramatic conformational switch from closed to open states upon substrate-binding, which enables specific substrate recognition for the 1''-O-linkage. The glutamate flap (Glu-41) blocks substrate entrance to Mg(2+) in the unliganded closed state. In presence of substrate, Glu-41 is ejected from the active site: this closed-to-open transition significantly widens the substrate-binding channel and precisely positions the scissile 1''-O-linkage for cleavage while securing tightly 2'- and 3'-hydroxyls of ADP-ribose.

9031:CLIC2
gene id: 9031:CLIC2
uniprot id: Q5ZKI1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9031:CALM2
gene id: 9031:CALM2
uniprot id: P62149
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

9031:HABP4
gene id: 9031:HABP4
uniprot id: Q9I9R0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with ribosomes; promoting ribosome stabilization (By similarity). Interacts with EEF2/eEF2; promoting ribosome stabilization (By similarity).
messages: Belongs to the SERBP1-HABP4 family.
messages: Cajal body
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature egg by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the egg and early embryo (By similarity).
messages: Stress granule
messages: The C-terminal region is necessary for nucleus and cytoplasmic localization. The N-terminal region is necessary for nucleus and nuclear bodies localization.
messages: gem
messages: nuclear body
messages: nucleolus
messages: sarcoplasm

9031:USP2
gene id: 9031:USP2
uniprot id: Q9YHZ2
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:IGF2BP2
gene id: 9031:IGF2BP2
uniprot id: A0A8V1A171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Cytoplasm

9031:VSIG1
gene id: 9031:VSIG1
uniprot id: Q9PWR4
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in thymocytes.
messages: Membrane

9031:TMEM59
gene id: 9031:TMEM59
uniprot id: Q5ZLJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:PRPF38A
gene id: 9031:PRPF38A
uniprot id: E1C6A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9031:S1PR3
gene id: 9031:S1PR3
uniprot id: A0A3Q2U344
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:PDGFC
gene id: 9031:PDGFC
uniprot id: Q9I946
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Expression increases in the spinal cord from 4 dpc to 16 dpc, with the highest level detected between 12 dpc and 16 dpc. Expression rapidly decreases after hatching.
messages: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, in angiogenesis and blood vessel development (By similarity).
messages: Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB (By similarity).
messages: Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form (By similarity).
messages: Secreted

9031:RBM46
gene id: 9031:RBM46
uniprot id: A0A8V0YQQ0
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ABLIM2
gene id: 9031:ABLIM2
uniprot id: A0A8V0YBK9
names: Subcellular Location Annotation
messages: Cytoplasm

9031:PEX2
gene id: 9031:PEX2
uniprot id: Q5ZM64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9031:NRG2
gene id: 9031:NRG2
uniprot id: A0A1D5PVP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:FAM168A
gene id: 9031:FAM168A
uniprot id: E1C589
names: Similarity
messages: Belongs to the FAM168 family.

9031:TRAPPC3L
gene id: 9031:TRAPPC3L
uniprot id: R4GMH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9031:SRC
gene id: 9031:SRC
uniprot id: P00523
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Becomes activated when its major tyrosine phosphorylation site is not phosphorylated. It can also be activated by point mutations as well as by truncations at the C-terminal end or by other mutations. Heme regulates its activity by enhancing the phosphorylation on Tyr-527 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Dephosphorylated at Tyr-527 by PTPRJ. Phosphorylated on Tyr-527 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-416. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-527, the SH3 domain engaged with the SH2-kinase linker, and Tyr-416 dephosphorylated. Dephosphorylation of Tyr-527 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-527, Tyr-416 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-527 by CSK allows this interaction to reform, resulting in SRC inactivation (By similarity).
messages: Endosome membrane
messages: Expressed to high levels, and with a high degree of kinase activity, in certain fully differentiated cells such as neurons, platelets and macrophages. Isoform 1 is widely expressed. Isoform 2 is expressed only in the muscle.
messages: Forms a complex with polyoma virus middle T antigen. Interacts with AFAP-110. Interacts with GJA1 and PXN.
messages: Membrane-bound.
messages: Mitochondrion inner membrane
messages: Myristoylated at Gly-2, and this is essential for targeting to membranes.
messages: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (By similarity). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:1717492, PubMed:8550628). Involved in anchorage-independent cell growth (PubMed:19307596).
messages: Nucleus
messages: S-nitrosylation is important for activation of its kinase activity.
messages: cytoskeleton
messages: focal adhesion
messages: perinuclear region

9031:PTPN11
gene id: 9031:PTPN11
uniprot id: Q90687
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm
messages: Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells.
messages: Phosphorylated by tyrosine-protein kinases.
messages: This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation (By similarity). The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation (PubMed:8921851).

9031:S100B
gene id: 9031:S100B
uniprot id: E1C251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9031:BFSP1
gene id: 9031:BFSP1
uniprot id: Q06637
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Detected in eye lens fiber cells (at protein level). Detected in embryonic eye lens.
messages: Required for the correct formation of lens intermediate filaments.
messages: cell cortex
messages: cytoskeleton

9031:VPS72
gene id: 9031:VPS72
uniprot id: H9KYW9
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9031:NT5DC3
gene id: 9031:NT5DC3
uniprot id: A0A1D5PNR2
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9031:KDM6A
gene id: 9031:KDM6A
uniprot id: A0A8V0YAX4
uniprot id: A0A8V0YD52
uniprot id: V9GWR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTX family.
messages: Nucleus

9031:SLC45A4
gene id: 9031:SLC45A4
uniprot id: A0A1D5NU91
names: Subcellular Location Annotation
messages: Membrane

9031:SF3A2
gene id: 9031:SF3A2
uniprot id: Q66VY4
names: Similarity
messages: Belongs to the SF3A2 family.

9031:HBA1
gene id: 9031:HBA1
uniprot id: P01994
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.
messages: This alpha chain is from the adult major tetrameric component, which has been called hemoglobin A or AII.

9031:MRPL42
gene id: 9031:MRPL42
uniprot id: F1NWY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9031:LAPTM4A
gene id: 9031:LAPTM4A
uniprot id: Q5ZML7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAPTM4/LAPTM5 transporter family.
messages: Endomembrane system
messages: May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.
messages: The C-terminal domain is necessary for retention within intracellular membranes.

9031:ATP5I
gene id: 9031:ATP5I
uniprot id: Q9YH14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9031:LPCAT1
gene id: 9031:LPCAT1
uniprot id: A0A8V0XY23
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9031:GINS2
gene id: 9031:GINS2
uniprot id: A0A1D5PQM4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9031:APCDD1
gene id: 9031:APCDD1
uniprot id: Q5R2I8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APCDD1 family.
messages: Cell membrane
messages: Expressed in the dorsal somite derivatives of the chicken as well as in the dorsal subpopulation of trunk crest cells.
messages: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin.

9031:C1orf158
gene id: 9031:C1orf158
uniprot id: Q9YH28
names: Function
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.

9031:FBXO34
gene id: 9031:FBXO34
uniprot id: Q5ZI71
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9031:NOS2
gene id: 9031:NOS2
uniprot id: Q90703
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: By treatment with lipopolysaccharides (LPS) or cytokines, but not in osteoclasts where they are induced by calcium and PMA (phorbol 12-myristate 13-acetate).
messages: Homodimer.
messages: Not stimulated by calcium/calmodulin.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO may serve as both a paracrine and autocrine signal for modulating osteoclast bone resorption. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 (By similarity).
messages: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
messages: cytosol

9031:RFFL
gene id: 9031:RFFL
uniprot id: Q5ZI26
names: Subcellular Location Annotation
messages: Cell membrane

9031:PPARA
gene id: 9031:PPARA
uniprot id: A0A1D5PJQ2
uniprot id: Q9I8W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9031:GINS3
gene id: 9031:GINS3
uniprot id: A0A1D5PWI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9031:APC2
gene id: 9031:APC2
uniprot id: D2W6W9
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9031:PLXND1
gene id: 9031:PLXND1
uniprot id: A0A3Q2U1R1
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GLDC
gene id: 9031:GLDC
uniprot id: P15505
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GcvP family.
messages: Homodimer. Interacts with GCSH. The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH).
messages: Liver (at protein level).
messages: Mitochondrion
messages: Stimulated by lipoic acid. Inhibited in presence of methylamine.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).

9031:GRM8
gene id: 9031:GRM8
uniprot id: A0A8V0XA35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9031:SKI
gene id: 9031:SKI
uniprot id: A0A8V0ZCW4
uniprot id: A0A8V0ZCW9
uniprot id: P49140
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKI family.
messages: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. May function in TGF-beta signaling (By similarity).
messages: Nucleus

9031:STX10
gene id: 9031:STX10
uniprot id: Q5ZL19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane
messages: Recycling endosome membrane
messages: SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway.
messages: trans-Golgi network membrane

9031:SAMM50
gene id: 9031:SAMM50
uniprot id: E1C8A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

9031:CCDC50
gene id: 9031:CCDC50
uniprot id: Q5ZM86
names: Function
names: PTM
messages: Involved in EGFR signaling.
messages: Phosphorylated on tyrosine residues.

9031:ZFPM2
gene id: 9031:ZFPM2
uniprot id: A0A1D5PTA6
names: Subcellular Location Annotation
messages: Nucleus

9031:HIST1H46
gene id: 9031:HIST1H46
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:LOC420362
gene id: 9031:LOC420362
uniprot id: P38529
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HSF family.
messages: Cytoplasm
messages: Expressed during development.
messages: Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:8455593). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (By similarity). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells. Plays a role in nuclear export of stress-induced mRNA. Plays a role in the regulation of mitotic progression. Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress-induced cancer cell proliferation.
messages: In unstressed cells, spontaneous homotrimerization is inhibited. Intramolecular interactions between the hydrophobic repeat HR-A/B and HR-C regions are necessary to maintain HSF1 in the inactive, monomeric conformation. In heat stressed cells, HSF1 homotrimerization occurs through formation of a three-stranded coiled-coil structure generated by intermolecular interactions between HR-A/B regions allowing DNA-binding activity. The D domain is necessary for translocation to the nucleus. 9aaTAD is a transactivation motif present in a large number of yeast and animal transcription factors.
messages: Low expression found in most tissues with the exception of blood and liver. Highest levels are found in the pigmental layer of retina and in the lymphoblastoid cell line MSB-1.
messages: Monomer; cytoplasmic latent and transcriptionally inactive monomeric form in unstressed cells. Homotrimer; in response to stress, such as heat shock, homotrimerizes and translocates into the nucleus, binds to heat shock element (HSE) sequences in promoter of heat shock protein (HSP) genes and acquires transcriptional ability.
messages: Nucleus
messages: centrosome
messages: kinetochore
messages: nucleoplasm
messages: perinuclear region
messages: spindle pole

9031:SENP8
gene id: 9031:SENP8
uniprot id: R4GKQ2
names: Similarity
messages: Belongs to the peptidase C48 family.

9031:DCTN2
gene id: 9031:DCTN2
uniprot id: A0A1D5PFB8
names: Similarity
messages: Belongs to the dynactin subunit 2 family.

9031:PXMP4
gene id: 9031:PXMP4
uniprot id: E1C5N7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9031:CNTFR
gene id: 9031:CNTFR
uniprot id: P51641
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Binds to CNTF (GPA). The alpha subunit provides the receptor specificity.
messages: Cell membrane
messages: Heterotrimer of the alpha subunit, LIFR and IL6ST.
messages: Highly expressed in nervous system. Also found in skeletal muscle.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

9031:MCCC2
gene id: 9031:MCCC2
uniprot id: F1P531
names: Similarity
messages: Belongs to the AccD/PCCB family.

9031:MMACHC
gene id: 9031:MMACHC
uniprot id: Q5ZL21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMACHC family.
messages: Can utilize both FAD and FMN.
messages: Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle. Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether. The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors. Cysteine and homocysteine cannot substitute for glutathione in this reaction.
messages: Monomer in the absence of bound substrate. Homodimer; dimerization is triggered by binding to FMN or adenosylcobalamin. Heterodimer with MMADHC.
messages: cytosol

9031:N4BP1
gene id: 9031:N4BP1
uniprot id: Q5ZLE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP1 family.
messages: Nucleus
messages: PML body
messages: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (By similarity). Has ribonuclease activity (By similarity).
messages: cytosol
messages: nucleolus

9031:COL6A1
gene id: 9031:COL6A1
uniprot id: P20785
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type VI collagen family.
messages: Collagen VI acts as a cell-binding protein.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: Trimers composed of three different chains: alpha 1(VI), alpha 2(VI), and alpha 3(VI).
messages: extracellular matrix

9031:NOL10
gene id: 9031:NOL10
uniprot id: E1BXP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9031:HMX1
gene id: 9031:HMX1
uniprot id: Q9DE09
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At stage 11, expressed in the surface ectoderm surrounding the optic vesicle. At stage 15, expressed in anterior/nasal side of the early retina. At stage 26, during the peak period of ganglion cell genesis, highly expressed in the nasal retina and the lens ectoderm.
messages: Belongs to the HMX homeobox family.
messages: DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear.
messages: Nucleus

9031:PAX2
gene id: 9031:PAX2
uniprot id: Q9PTX1
names: Subcellular Location Annotation
messages: Nucleus

9031:PLPPR1
gene id: 9031:PLPPR1
uniprot id: F1N9B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9031:IRF7
gene id: 9031:IRF7
uniprot id: Q90643
uniprot id: Q90ZD4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the IRF-1 binding site PRD-I.
messages: Nucleus
messages: Up-regulated by poly I:C.
messages: Widely expressed with higher expression in lung, spleen and intestine.

9031:GDF6
gene id: 9031:GDF6
uniprot id: A0A1D5P0D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9031:TNNT3
gene id: 9031:TNNT3
uniprot id: O57559
uniprot id: P12620
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9031:CCR6
gene id: 9031:CCR6
uniprot id: B0BL89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9031:TMEM14A
gene id: 9031:TMEM14A
uniprot id: A0A8V0X8M4
uniprot id: A0A8V0XEF4
names: Similarity
messages: Belongs to the TMEM14 family.

9031:PKD2
gene id: 9031:PKD2
uniprot id: Q5ZM00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

9031:IFIH1
gene id: 9031:IFIH1
uniprot id: D9N195
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9031:GPR15
gene id: 9031:GPR15
uniprot id: A0A4Y5QY96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:PMM2
gene id: 9031:PMM2
uniprot id: Q5ZJ50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9031:RPS11
gene id: 9031:RPS11
uniprot id: Q98TH5
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9031:MYOD1
gene id: 9031:MYOD1
uniprot id: P16075
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).
messages: Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2.
messages: Nucleus

9031:SLC25A33
gene id: 9031:SLC25A33
uniprot id: E1C5T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:MON1A
gene id: 9031:MON1A
uniprot id: F1NBQ4
uniprot id: Q5ZIH2
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.
messages: Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes.

9031:LONP1
gene id: 9031:LONP1
uniprot id: A0A1D5NYJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Mitochondrion matrix
messages: Nucleus

9031:ERH
gene id: 9031:ERH
uniprot id: Q5ZI09
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9031:EXOC3L4
gene id: 9031:EXOC3L4
uniprot id: F1P1M3
names: Similarity
messages: Belongs to the SEC6 family.

9031:PIK3C2B
gene id: 9031:PIK3C2B
uniprot id: A0A1D5PQ64
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:PFN2
gene id: 9031:PFN2
uniprot id: Q5ZL50
names: Similarity
messages: Belongs to the profilin family.

9031:TMEM173
gene id: 9031:TMEM173
uniprot id: A0A0K1YW01
uniprot id: E1C7U0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (By similarity). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (By similarity). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed:30842659). Upon binding of c-di-GMP or cGAMP, STING1 oligomerizes and is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state (PubMed:30842659). In addition to promote the production of type I interferons, plays a direct role in autophagy (By similarity). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (By similarity). The ERGIC serves as the membrane source for LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (By similarity). The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (By similarity). Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (By similarity).
messages: Golgi apparatus membrane
messages: Homodimer; forms a homodimer in absence of cyclic nucleotide (c-di-GMP or cGAMP) (PubMed:30842659). Homotetramer; in presence of cyclic nucleotide (c-di-GMP or cGAMP), forms tetramers and higher-order oligomers through side-by-side packing (PubMed:30842659). Interacts (when phosphorylated) with IRF3; following activation and phosphorylation on the pLxIS motif by TBK1, recruits IRF3 (By similarity).
messages: In absence of cGAMP, the transmembrane and cytoplasmic regions interact to form an integrated, domain-swapped dimeric assembly (PubMed:30842659). In absence of cyclic nucleotide (c-di-GMP or cGAMP), the protein is autoinhibited by an intramolecular interaction between the cyclic dinucleotide-binding domain (CBD) and the C-terminal tail (CTT) (By similarity). Following cGAMP-binding, the cyclic dinucleotide-binding domain (CBD) is closed, leading to a 180 degrees rotation of the CBD domain relative to the transmembrane domain (PubMed:30842659). This rotation is coupled to a conformational change in a loop on the side of the CBD dimer, which leads to the formation of the STING1 tetramer and higher-order oligomers through side-by-side packing (PubMed:30842659). The N-terminal part of the CBD region was initially though to contain a fifth transmembrane region (TM5) but is part of the folded, soluble CBD (By similarity).
messages: Phosphorylation by TBK1 leads to activation and production of IFN-beta (Probable). Following cyclic nucleotide (c-di-GMP or cGAMP)-binding, activation and translocation from the endoplasmic reticulum, STING1 is phosphorylated by TBK1 at Ser-366 in the pLxIS motif (Probable). The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines (Probable).
messages: The N-terminal domain interacts with glycerophospholipids and phospholipids.
messages: The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of STING1 recruits IRF3. IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines.
messages: autophagosome membrane
messages: perinuclear region

9031:TAF10
gene id: 9031:TAF10
uniprot id: A0A8V0X372
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus

9031:LOC100858777
gene id: 9031:LOC100858777
uniprot id: A0A8V0XV66
names: Subcellular Location Annotation
messages: Membrane

9031:TCP1
gene id: 9031:TCP1
uniprot id: Q5ZMG9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

9031:RNF146
gene id: 9031:RNF146
uniprot id: A0A8V0XC69
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9031:BZW2
gene id: 9031:BZW2
uniprot id: F1NM03
uniprot id: Q5ZL42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BZW family.
messages: Cytoplasm
messages: Translation initiation regulator which may repress non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function.

9031:CLDN1
gene id: 9031:CLDN1
uniprot id: Q5ZMG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:INSIG2
gene id: 9031:INSIG2
uniprot id: Q5F3W2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex; association is mediated via its interaction with SCAP and only takes place in the presence of sterols.
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBPs to the Golgi. Sterol deprivation reduces oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs. Also regulates cholesterol synthesis by regulating degradation of HMGCR.
messages: The KxHxx motif mediates association with the coatomer complex.

9031:BMI1
gene id: 9031:BMI1
uniprot id: Q5SDR3
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a PRC1-like complex.
messages: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.
messages: Cytoplasm
messages: During early nervous system development, robust expression was observed in the open neural plate and later in the dorsal neural tube and much of the brain. Also present in the developing heart primordia and the sensory placodes.
messages: Nucleus

9031:FURIN
gene id: 9031:FURIN
uniprot id: Q91000
names: Similarity
messages: Belongs to the peptidase S8 family.

9031:EHF
gene id: 9031:EHF
uniprot id: A0A8V1A5F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:BAZ1B
gene id: 9031:BAZ1B
uniprot id: A0A8V1AMK9
names: Subcellular Location Annotation
messages: Nucleus

9031:KCNK2
gene id: 9031:KCNK2
uniprot id: A0A8V0Z908
uniprot id: F1NZ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9031:IL18
gene id: 9031:IL18
uniprot id: Q9I8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Secreted

9031:CAB39L
gene id: 9031:CAB39L
uniprot id: A0A1L1RL30
uniprot id: F1NV80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9031:CXCL13
gene id: 9031:CXCL13
uniprot id: A0A1L1RZN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9031:SBDS
gene id: 9031:SBDS
uniprot id: Q5ZIY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 60S ribosomal subunit.
messages: Belongs to the SDO1/SBDS family.
messages: Cytoplasm
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).
messages: nucleolus
messages: nucleoplasm
messages: spindle

9031:GTF2H2
gene id: 9031:GTF2H2
uniprot id: E1C9E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9031:TIMM10B
gene id: 9031:TIMM10B
uniprot id: A0A1D5PN84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9031:MOS
gene id: 9031:MOS
uniprot id: P10741
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

9031:RHPN2
gene id: 9031:RHPN2
uniprot id: A0A8V1A0H8
names: Similarity
messages: Belongs to the RHPN family.

9031:CHMP2A
gene id: 9031:CHMP2A
uniprot id: Q5ZHN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).

9031:PKIG
gene id: 9031:PKIG
uniprot id: A0A8V0ZZ48
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9031:SLC30A9
gene id: 9031:SLC30A9
uniprot id: A0A8V0YTW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

9031:FABP7
gene id: 9031:FABP7
uniprot id: Q05423
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: Highest expression in early stages of retinal development with a 50-100 fold decrease from day 3 to day 19 of retina maturation.

9031:DNAJA4
gene id: 9031:DNAJA4
uniprot id: A0A1D5NYA8
names: Subcellular Location Annotation
messages: Membrane

9031:MGRN1
gene id: 9031:MGRN1
uniprot id: A0A8V0Z4C8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9031:TMEM136-1
gene id: 9031:TMEM136-1
uniprot id: A0A1D5NZD1
names: Subcellular Location Annotation
messages: Membrane

9031:KCNAB1
gene id: 9031:KCNAB1
uniprot id: Q9PWR1
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (By similarity). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).
messages: Homotetramer (By similarity). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (Probable).
messages: In the inner ear, expression detected in the otocyst at embryonic day 3 and in the whole cochlea at E 6. Expressed throughout embryonic development and adulthood.
messages: Membrane
messages: The N-terminal domain of the beta subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore.

9031:C6orf89
gene id: 9031:C6orf89
uniprot id: Q5F344
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9031:LOC395368
gene id: 9031:LOC395368
uniprot id: Q9DDC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:SIX2
gene id: 9031:SIX2
uniprot id: Q3C2H7
names: Subcellular Location Annotation
messages: Nucleus

9031:CACUL1
gene id: 9031:CACUL1
uniprot id: Q5ZMM9
names: Similarity
messages: Belongs to the cullin family.

9031:NOG2
gene id: 9031:NOG2
uniprot id: Q2NNA6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Secreted

9031:AIFM1
gene id: 9031:AIFM1
uniprot id: Q5ZHL7
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

9031:SUV39H2
gene id: 9031:SUV39H2
uniprot id: Q5F3W5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Nucleus
messages: centromere

9031:GRK5
gene id: 9031:GRK5
uniprot id: E1BQG4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9031:INTS2
gene id: 9031:INTS2
uniprot id: Q5ZKU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 2 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus membrane

9031:ARFGEF1
gene id: 9031:ARFGEF1
uniprot id: A0A1D5P6U6
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9031:SNTN
gene id: 9031:SNTN
uniprot id: B7FF67
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 'Sentan' means 'tip' in Japanese.
messages: Belongs to the S-100 family.
messages: May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.
messages: cilium

9031:KLHL20
gene id: 9031:KLHL20
uniprot id: Q5ZKD9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL20 and RBX1.
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity).
messages: perinuclear region

9031:PHACTR2
gene id: 9031:PHACTR2
uniprot id: A0A1D5PSM4
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9031:AQP9
gene id: 9031:AQP9
uniprot id: A0A1D5PEK7
uniprot id: A7VMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9031:SPAST
gene id: 9031:SPAST
uniprot id: A0A1L1RV27
uniprot id: Q5ZK92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.
messages: Belongs to the AAA ATPase family.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules.
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cytoskeleton
messages: perinuclear region

9031:GOT2
gene id: 9031:GOT2
uniprot id: P00508
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism.
messages: Detected in heart (at protein level).
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
messages: Mitochondrion matrix

9031:IP6K1
gene id: 9031:IP6K1
uniprot id: A0A8V1A6L5
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9031:NUDT3
gene id: 9031:NUDT3
uniprot id: E1C4K9
names: Similarity
messages: Belongs to the Nudix hydrolase family. DIPP subfamily.

9031:LDLRAD1
gene id: 9031:LDLRAD1
uniprot id: A0A8V1A2C1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ANKMY2
gene id: 9031:ANKMY2
uniprot id: Q5ZMD2
names: Function
names: Subcellular Location Annotation
messages: May be involved in the trafficking of signaling proteins to the cilia.
messages: cilium

9031:CLCN3
gene id: 9031:CLCN3
uniprot id: A0A8V0Y6E9
uniprot id: E1C9F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9031:SCN9A
gene id: 9031:SCN9A
uniprot id: E1C4S2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9031:CFLAR
gene id: 9031:CFLAR
uniprot id: E1C4U6
uniprot id: E9NPB4
names: Similarity
messages: Belongs to the peptidase C14A family.

9031:ACP1
gene id: 9031:ACP1
uniprot id: A0A1D5P9Z1
uniprot id: Q5ZKG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9031:PRKAA2
gene id: 9031:PRKAA2
uniprot id: Q2LAI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm
messages: Nucleus

9031:HAO2
gene id: 9031:HAO2
uniprot id: A0A8V0ZWE6
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9031:RCAN2
gene id: 9031:RCAN2
uniprot id: A0A8V0XZ08
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9031:NDUFAF4
gene id: 9031:NDUFAF4
uniprot id: E1C7K8
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9031:PDLIM3
gene id: 9031:PDLIM3
uniprot id: Q9PU47
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Interacts with alpha-actinin.
messages: Isoform 1 is expressed in heart and in tissues enriched in smooth muscle including arteries, stomach, gizzard, intestine, and lung. Isoform 2 is skeletal muscle-specific. Isoform 1 and isoform 2 are up-regulated during myogenic differentiation.
messages: May play a role in the organization of actin filament arrays within muscle cells.
messages: Z line
messages: cytoskeleton
messages: lamellipodium

9031:MPP5
gene id: 9031:MPP5
uniprot id: E1C3F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: tight junction

9031:ING3
gene id: 9031:ING3
uniprot id: Q5ZK36
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity).
messages: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9031:SEPTIN2L
gene id: 9031:SEPTIN2L
uniprot id: Q5ZMH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity).
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Can form heterooligomers with other family members and form filaments (By similarity).
messages: cell cortex
messages: cilium membrane
messages: cytoskeleton
messages: spindle

9031:SCN2A
gene id: 9031:SCN2A
uniprot id: A0A8V1A5Z8
uniprot id: E1BQT2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9031:BTN1A1
gene id: 9031:BTN1A1
uniprot id: Q49K83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9031:PSMC6
gene id: 9031:PSMC6
uniprot id: Q5ZKX2
names: Similarity
messages: Belongs to the AAA ATPase family.

9031:CYBA
gene id: 9031:CYBA
uniprot id: Q5ZKT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9031:LOC427665
gene id: 9031:LOC427665
uniprot id: A0A8V0Z2V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9031:TPM3
gene id: 9031:TPM3
uniprot id: Q5ZLJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9031:TAPT1
gene id: 9031:TAPT1
uniprot id: Q5ZLG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane
messages: Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 during development. May be involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells.
messages: centrosome
messages: cilium basal body

9031:TOE1
gene id: 9031:TOE1
uniprot id: F1N9P8
names: Similarity
messages: Belongs to the CAF1 family.

9031:ELAPOR2
gene id: 9031:ELAPOR2
uniprot id: A0A8V0XTY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9031:RARRES2
gene id: 9031:RARRES2
uniprot id: A0A0K0PUH6
names: Subcellular Location Annotation
messages: Secreted

9031:YME1L1
gene id: 9031:YME1L1
uniprot id: Q5ZIG8
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9031:CNOT7
gene id: 9031:CNOT7
uniprot id: Q5ZJV9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAF1 family.
messages: Binds 2 divalent metal cations per subunit with RNAase activity being higher in presence of Mn(2+) than of Mg(2+) or Co(2+).
messages: Component of the CCR4-NOT complex.
messages: Cytoplasm
messages: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity).
messages: Nucleus

9031:SIAH1
gene id: 9031:SIAH1
uniprot id: F1P2G0
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9031:PDE6G
gene id: 9031:PDE6G
uniprot id: Q802E4
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9031:BECN1
gene id: 9031:BECN1
uniprot id: Q5ZKS6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beclin family.
messages: Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: May be proteolytically processed by caspases; the C-terminal fragment(s) may induce apoptosis.
messages: Mitochondrion membrane
messages: Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity).
messages: autophagosome
messages: trans-Golgi network membrane

9031:DNA2
gene id: 9031:DNA2
uniprot id: Q5ZKG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function (By similarity).
messages: Mitochondrion
messages: Nucleus

9031:TECTB
gene id: 9031:TECTB
uniprot id: P54097
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Exclusively expressed in the inner ear, where it is found in basilar papilla, clear cells, supporting cells, cuboidal cells and the lagena macula.
messages: May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.
messages: N-glycosylated.
messages: One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
messages: The N-terminus is blocked.
messages: The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.
messages: Zona pellucida domain may enable to form filaments.
messages: extracellular matrix

9031:CYB5R2
gene id: 9031:CYB5R2
uniprot id: Q5ZHX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Membrane
messages: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis and drug metabolism.

9031:KPNA4
gene id: 9031:KPNA4
uniprot id: Q5ZLF7
names: Similarity
messages: Belongs to the importin alpha family.

9031:FBLN1
gene id: 9031:FBLN1
uniprot id: O73775
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: extracellular matrix

9031:BRCA1
gene id: 9031:BRCA1
uniprot id: Q90Z51
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm
messages: Nucleus

9031:NDUFV2
gene id: 9031:NDUFV2
uniprot id: A0A1D5PI06
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9031:CHORDC1
gene id: 9031:CHORDC1
uniprot id: Q5ZML4
names: Function
messages: Regulates centrosome duplication.

9031:STK17A
gene id: 9031:STK17A
uniprot id: Q5ZMU4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:LOC100857439
gene id: 9031:LOC100857439
uniprot id: P84229
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

9031:DNAJC16
gene id: 9031:DNAJC16
uniprot id: Q5ZKZ4
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

9031:EIF4A2
gene id: 9031:EIF4A2
uniprot id: Q8JFP1
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E (By similarity).

9031:BTK
gene id: 9031:BTK
uniprot id: Q5ZLF2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9031:HIST2H3D
gene id: 9031:HIST2H3D
uniprot id: P84229
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

9031:YAF2
gene id: 9031:YAF2
uniprot id: Q5ZKC5
names: Subcellular Location Annotation
messages: Nucleus

9031:GHRL
gene id: 9031:GHRL
uniprot id: Q7T2V1
uniprot id: Q8AV73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Secreted

9031:DDX10
gene id: 9031:DDX10
uniprot id: Q5ZJF6
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
messages: Putative ATP-dependent RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9031:ART1L2
gene id: 9031:ART1L2
uniprot id: Q49L19
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9031:SUPV3L1
gene id: 9031:SUPV3L1
uniprot id: Q5ZJT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: mitochondrion nucleoid

9031:ALDH4A1
gene id: 9031:ALDH4A1
uniprot id: A0A1D5PXI1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9031:MFSD5
gene id: 9031:MFSD5
uniprot id: A0A8V1A628
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

9031:FGD3
gene id: 9031:FGD3
uniprot id: A0A1D5NVP9
uniprot id: A0A8V1AAD2
uniprot id: F1P409
names: Subcellular Location Annotation
messages: cytoskeleton

9031:RBBP7
gene id: 9031:RBBP7
uniprot id: Q9I8G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Also interacts with histone H2B and HAT1.
messages: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism.
messages: Nucleus

9031:LYRM4
gene id: 9031:LYRM4
uniprot id: A0A8V0Y332
names: Similarity
messages: Belongs to the complex I LYR family.

9031:INSL5
gene id: 9031:INSL5
uniprot id: A0A8K1B0R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9031:SMPX
gene id: 9031:SMPX
uniprot id: F1NJ53
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

9031:ALDH3A2
gene id: 9031:ALDH3A2
uniprot id: Q5ZLE2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9031:FAM3D
gene id: 9031:FAM3D
uniprot id: E1C5S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9031:LUC7L2
gene id: 9031:LUC7L2
uniprot id: Q5ZLW7
names: Similarity
messages: Belongs to the Luc7 family.

9031:NCS1
gene id: 9031:NCS1
uniprot id: P62167
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the recoverin family.
messages: Binds 3 calcium ions via the second, third and fourth EF-hand.
messages: Cell membrane
messages: Cytoplasm
messages: Found in embryos from 3 dpc to adult stages.
messages: Golgi apparatus
messages: Interacts with KCND2.
messages: Membrane
messages: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin.
messages: Post-mitotic neurons in the central and peripheral nervous system.
messages: Postsynaptic density
messages: perinuclear region

9031:LOC776275
gene id: 9031:LOC776275
uniprot id: A0A8V0ZGT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9031:FAM26F
gene id: 9031:FAM26F
uniprot id: E1C3Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9031:RBM22
gene id: 9031:RBM22
uniprot id: Q5ZM16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLT11 family.
messages: Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex.
messages: Cytoplasm
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.
messages: The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.

9031:MFAP1
gene id: 9031:MFAP1
uniprot id: R4GGG5
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9031:SLC35C2
gene id: 9031:SLC35C2
uniprot id: Q5ZJ63
names: Subcellular Location Annotation
messages: Membrane

9031:YAP1
gene id: 9031:YAP1
uniprot id: P46936
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YAP1 family.
messages: Cell junction
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by LATS1 and LATS2; leading to cytoplasmic translocation and inactivation.
messages: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation (By similarity).

9031:STAG1
gene id: 9031:STAG1
uniprot id: A0A8V0ZXE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9031:MYL3
gene id: 9031:MYL3
uniprot id: P02606
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.

9031:CBLB
gene id: 9031:CBLB
uniprot id: A0A8V0XF80
uniprot id: F1NL77
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9031:ZDHHC3
gene id: 9031:ZDHHC3
uniprot id: A0A1D5PVV6
uniprot id: A0A8V0YWA3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:YPEL2
gene id: 9031:YPEL2
uniprot id: Q5ZI07
names: Similarity
messages: Belongs to the yippee family.

9031:BARX2
gene id: 9031:BARX2
uniprot id: Q9W694
names: Subcellular Location Annotation
messages: Nucleus

9031:LOC107057524
gene id: 9031:LOC107057524
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:EIF2B4
gene id: 9031:EIF2B4
uniprot id: A0A8V0Y8H7
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9031:DDX4
gene id: 9031:DDX4
uniprot id: F1N991
names: Similarity
messages: Belongs to the DEAD box helicase family.

9031:RIN3
gene id: 9031:RIN3
uniprot id: F1NUN3
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9031:TSEN15
gene id: 9031:TSEN15
uniprot id: A0A8V0YIN1
names: Similarity
messages: Belongs to the SEN15 family.

9031:EME1
gene id: 9031:EME1
uniprot id: A0A8V1AJR5
names: Similarity
messages: Belongs to the EME1/MMS4 family.

9031:TSPO2
gene id: 9031:TSPO2
uniprot id: F1NNL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9031:BIRC7
gene id: 9031:BIRC7
uniprot id: A0A8V1A062
names: Similarity
messages: Belongs to the IAP family.

9031:ZAR1L
gene id: 9031:ZAR1L
uniprot id: D2SYX9
names: Similarity
messages: Belongs to the ZAR1 family.

9031:KCNV1
gene id: 9031:KCNV1
uniprot id: A0A1D5PA94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9031:CDH18
gene id: 9031:CDH18
uniprot id: A0A1D5PKP1
uniprot id: A0A1D5PZT9
uniprot id: A0A8V0X6G9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

9031:CORO7
gene id: 9031:CORO7
uniprot id: Q5ZLL2
names: Similarity
messages: Belongs to the WD repeat coronin family.

9031:GNS
gene id: 9031:GNS
uniprot id: F1NI04
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:ATP6V0D2
gene id: 9031:ATP6V0D2
uniprot id: Q5ZHL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Regulator of osteoclast fusion and bone formation (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9031:LOC415756
gene id: 9031:LOC415756
uniprot id: A0A8V0ZYS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

9031:ZNF330
gene id: 9031:ZNF330
uniprot id: A0A1L1RUJ1
uniprot id: E1C2N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

9031:FNDC3A
gene id: 9031:FNDC3A
uniprot id: Q5ZJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNDC3 family.
messages: Golgi apparatus membrane

9031:COPS5
gene id: 9031:COPS5
uniprot id: Q5ZLC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9031:SLU7
gene id: 9031:SLU7
uniprot id: Q5ZIG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLU7 family.
messages: Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

9031:PIGM
gene id: 9031:PIGM
uniprot id: Q5F380
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity).

9031:PPP2R2D
gene id: 9031:PPP2R2D
uniprot id: Q5ZIY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Cytoplasm
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity).

9031:MSL3
gene id: 9031:MSL3
uniprot id: A0A1D5PS75
names: Subcellular Location Annotation
messages: Nucleus

9031:NCAN
gene id: 9031:NCAN
uniprot id: Q9W6E1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SEC22A
gene id: 9031:SEC22A
uniprot id: Q5ZIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9031:DOHH
gene id: 9031:DOHH
uniprot id: Q5ZIP3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.

9031:RAB3C
gene id: 9031:RAB3C
uniprot id: E1C105
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9031:GNRH1
gene id: 9031:GNRH1
uniprot id: G8HN01
uniprot id: P37042
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins.

9031:LGSN
gene id: 9031:LGSN
uniprot id: Q2PT42
names: Similarity
messages: Belongs to the glutamine synthetase family.

9031:CDV3
gene id: 9031:CDV3
uniprot id: Q5ZLH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDV3 family.
messages: Cytoplasm

9031:SF3A1
gene id: 9031:SF3A1
uniprot id: F1NU16
names: Subcellular Location Annotation
messages: Nucleus

9031:GRM1
gene id: 9031:GRM1
uniprot id: F1NBM2
uniprot id: I3XHQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9031:ZPBP2
gene id: 9031:ZPBP2
uniprot id: Q6PVW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: May be implicated in the gamete interaction during fertilization.
messages: Secreted
messages: acrosome

9031:NNT
gene id: 9031:NNT
uniprot id: A0A8V0YW04
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9031:MRPL43
gene id: 9031:MRPL43
uniprot id: Q5ZHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9031:AKR1A1
gene id: 9031:AKR1A1
uniprot id: Q5ZK84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Displays no reductase activity towards retinoids (By similarity).
messages: cytosol

9031:TEKT1
gene id: 9031:TEKT1
uniprot id: A0A8V1AN17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

9031:CRYAB
gene id: 9031:CRYAB
uniprot id: Q05713
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens.
messages: Lens as well as other tissues.
messages: May contribute to the transparency and refractive index of the lens.

9031:PIK3C3
gene id: 9031:PIK3C3
uniprot id: A0A8V0Y2K1
uniprot id: A0A8V0Y499
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:PNOC
gene id: 9031:PNOC
uniprot id: D7RXN8
uniprot id: E1BRK8
names: Similarity
messages: Belongs to the opioid neuropeptide precursor family.

9031:UQCR10
gene id: 9031:UQCR10
uniprot id: F1NC51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9031:FGD5
gene id: 9031:FGD5
uniprot id: E1BQN2
names: Subcellular Location Annotation
messages: cytoskeleton

9031:CLDN11
gene id: 9031:CLDN11
uniprot id: E1BR31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:NLGN4Y
gene id: 9031:NLGN4Y
uniprot id: D2X2H2
uniprot id: D3WGL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9031:NGB
gene id: 9031:NGB
uniprot id: Q5QSB1
names: Similarity
messages: Belongs to the globin family.

9031:FAM49A
gene id: 9031:FAM49A
uniprot id: A0A1D5PP47
uniprot id: A0A8V0XET4
uniprot id: Q5ZI04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: May negatively regulate RAC1 signaling and RAC1-driven cytoskeletal remodeling. May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions.
messages: Membrane

9031:ORC1
gene id: 9031:ORC1
uniprot id: Q5ZMC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

9031:HOXB1
gene id: 9031:HOXB1
uniprot id: A0A8V0ZWJ5
names: Subcellular Location Annotation
messages: Nucleus

9031:CXXC5
gene id: 9031:CXXC5
uniprot id: F1NCW6
names: Subcellular Location Annotation
messages: Cytoplasm

9031:AKAP9
gene id: 9031:AKAP9
uniprot id: Q9W6V0
names: Subcellular Location Annotation
messages: centrosome

9031:FEN1
gene id: 9031:FEN1
uniprot id: Q5ZLN4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9031:NT5C2
gene id: 9031:NT5C2
uniprot id: A0A8V0ZHF7
uniprot id: A0A8V0ZNH9
uniprot id: Q5ZIZ4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by various compounds including ATP, 2,3-BPG/2,3-Bisphosphoglyceric acid and Ap4A/P1,P4-bis(5'-adenosyl) tetraphosphate. Binding of an allosteric activator is a prerequisiste to magnesium and substrate binding. Inhibited by inorganic phosphate (By similarity). Inhibited by inosine, guanosine, p-chloromercuribenzoate and NaF (PubMed:6060459).
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:6060459). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (By similarity). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:6060459). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (By similarity). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:6060459).
messages: Homotetramer.
messages: cytosol

9031:RAF1
gene id: 9031:RAF1
uniprot id: P05625
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Isoform 1 was present in all tissues tested: skeletal muscle, intestine, brain, gizzard, heart, lung, kidney, bone marrow, spleen and bursa of Fabricius. Isoform 2 was only detected in brain, heart and skeletal muscle. In brain and heart isoform 1 is more abundant than isoform 2. In skeletal muscle isoform 2 is more abundant than isoform 1.
messages: Phosphorylation at Ser-259 inactivates kinase activity. Dephosphorylation of Ser-259 by a complex containing protein phosphatase 1 relieves inactivation, leading to stimulate RAF1 activity (By similarity).
messages: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity).

9031:CISH
gene id: 9031:CISH
uniprot id: Q9PW70
names: Domain
names: Function
messages: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

9031:ELF5
gene id: 9031:ELF5
uniprot id: A0A8V1A5B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:PTN
gene id: 9031:PTN
uniprot id: P32760
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pleiotrophin family.
messages: Secreted
messages: Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity).

9031:PENK
gene id: 9031:PENK
uniprot id: E1C652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9031:TRAPPC13
gene id: 9031:TRAPPC13
uniprot id: A0A1L1RS53
uniprot id: A0A8V0YM10
uniprot id: Q5ZI92
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

9031:COLEC12
gene id: 9031:COLEC12
uniprot id: Q2LK54
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Membrane
messages: Scavenger receptor that displays several functions associated with host defense. Binds to carbohydrates (By similarity).
messages: Widely expressed.

9031:CARNS1
gene id: 9031:CARNS1
uniprot id: D3KCC4
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.
messages: Homotetramer.

9031:UNG
gene id: 9031:UNG
uniprot id: Q8AYC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

9031:ABCB5
gene id: 9031:ABCB5
uniprot id: F1NTA4
names: Subcellular Location Annotation
messages: Membrane

9031:FBP1
gene id: 9031:FBP1
uniprot id: A0A8V0Y0D1
names: Similarity
messages: Belongs to the FBPase class 1 family.

9031:PIK3R2
gene id: 9031:PIK3R2
uniprot id: E1C2C5
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9031:PRPF4
gene id: 9031:PRPF4
uniprot id: F1NNQ9
names: Subcellular Location Annotation
messages: Nucleus speckle

9031:RFTN2
gene id: 9031:RFTN2
uniprot id: A0A1D5PGW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9031:DTYMK
gene id: 9031:DTYMK
uniprot id: A0A1D5PKC2
names: Similarity
messages: Belongs to the thymidylate kinase family.

9031:SCN11A
gene id: 9031:SCN11A
uniprot id: F9W2X9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9031:PEPD
gene id: 9031:PEPD
uniprot id: Q5ZKL3
names: Similarity
messages: Belongs to the peptidase M24B family.

9031:HS6ST2
gene id: 9031:HS6ST2
uniprot id: Q76LW2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate (By similarity). May also play a role in limb development.
messages: Belongs to the sulfotransferase 6 family.
messages: Expressed in the developing wing bud. At stage 31, widely expressed with a higher level in limb and head.
messages: Membrane

9031:XK
gene id: 9031:XK
uniprot id: Q49M61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9031:MYH7
gene id: 9031:MYH7
uniprot id: Q910C5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:CBLL1
gene id: 9031:CBLL1
uniprot id: Q5ZHZ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Hakai family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.
messages: Homodimer (By similarity). Interacts with tyrosine-phosphorylated SRC substrates (By similarity). Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. Component of the MACOM subcomplex (By similarity).
messages: Nucleus speckle
messages: The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.
messages: nucleoplasm

9031:GALR2
gene id: 9031:GALR2
uniprot id: B2CL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:C22orf39
gene id: 9031:C22orf39
uniprot id: A0A1L1RQR8
names: Similarity
messages: Belongs to the UPF0545 family.

9031:FTCD
gene id: 9031:FTCD
uniprot id: Q9YH58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds and promotes bundling of vimentin filaments originating from the Golgi.
messages: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
messages: Golgi apparatus
messages: Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.
messages: In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
messages: In the N-terminal section; belongs to the formiminotransferase family.
messages: centriole
messages: cytosol

9031:VDR
gene id: 9031:VDR
uniprot id: A0A8V0ZSB9
uniprot id: O42392
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Expressed in kidney and intestine.
messages: Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding.
messages: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity).
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9031:HEXA
gene id: 9031:HEXA
uniprot id: Q5ZI46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9031:SLC25A6
gene id: 9031:SLC25A6
uniprot id: Q5ZLG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9031:KCNG2
gene id: 9031:KCNG2
uniprot id: O73606
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.
messages: Heterodimer with KCNB1. Does not form homomultimers (By similarity).
messages: Membrane
messages: Potassium channel subunit. Modulates channel activity (By similarity).
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

9031:CAPN2
gene id: 9031:CAPN2
uniprot id: Q92178
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.
messages: Belongs to the peptidase C2 family.
messages: Binds 7 Ca(2+) ions.
messages: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
messages: Ubiquitous.

9031:KARS
gene id: 9031:KARS
uniprot id: Q5ZKP8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9031:NDUFS6
gene id: 9031:NDUFS6
uniprot id: A0A8V0XV78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

9031:ACTN2
gene id: 9031:ACTN2
uniprot id: P20111
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-actinin family.
messages: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).
messages: Homodimer; antiparallel.
messages: Ubiquitinated by FBXL22, leading to proteasomal degradation.
messages: Z line

9031:PSEN2
gene id: 9031:PSEN2
uniprot id: A0A8V0Z5X8
uniprot id: F1NGP7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

9031:ABCD2
gene id: 9031:ABCD2
uniprot id: A0A1D5PHR1
names: Subcellular Location Annotation
messages: Membrane

9031:NAXD
gene id: 9031:NAXD
uniprot id: A0A8V0YHG3
names: Function
names: Similarity
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

9031:CEBPZ
gene id: 9031:CEBPZ
uniprot id: Q5ZIQ7
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9031:AHR1A
gene id: 9031:AHR1A
uniprot id: Q9I9E2
names: Subcellular Location Annotation
messages: Cytoplasm

9031:GPR39
gene id: 9031:GPR39
uniprot id: A1XWZ9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:HIST1H2A4
gene id: 9031:HIST1H2A4
uniprot id: P02263
uniprot id: Q92069
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).
messages: Monoubiquitination of Lys-120 (H2AK119Ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties, leading to the recruitment of repair proteins to sites of DNA damage. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:WNT11
gene id: 9031:WNT11
uniprot id: A0A8V0X957
uniprot id: P49339
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Expressed during embryogenesis.
messages: Expressed in the dermatome. The expression domain is mutually exclusive to the other Wnt genes.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

9031:FGFR1
gene id: 9031:FGFR1
uniprot id: P21804
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer and proceeds in a highly ordered manner. Phosphotyrosine residues provide docking sites for interacting proteins and so are crucial for FGFR1 function and its regulation (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Monomer. Homodimer after ligand binding (By similarity).
messages: N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus (By similarity).
messages: Nucleus
messages: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by sequential autophosphorylation on tyrosine residues (By similarity).
messages: The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Isoforms lacking the first Ig-like domain have higher affinity for fibroblast growth factors (FGF) and heparan sulfate proteoglycans than isoforms with all three Ig-like domains (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity).
messages: Ubiquitinated. FGFR1 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation (By similarity).
messages: cytosol

9031:GPER1
gene id: 9031:GPER1
uniprot id: C3VP78
uniprot id: F1NWC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:SLC35G2
gene id: 9031:SLC35G2
uniprot id: Q5ZJZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35G solute transporter family.
messages: Cell membrane
messages: synaptic vesicle membrane

9031:DNAJB12
gene id: 9031:DNAJB12
uniprot id: Q5F3M7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:LRP12
gene id: 9031:LRP12
uniprot id: A0A1D5PL81
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:MED18
gene id: 9031:MED18
uniprot id: R4GFA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:PDIA3
gene id: 9031:PDIA3
uniprot id: Q8JG64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum lumen
messages: Melanosome
messages: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone.

9031:LOC771638
gene id: 9031:LOC771638
uniprot id: A0A8V0ZAT6
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9031:TAC3
gene id: 9031:TAC3
uniprot id: A0A8K1AZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9031:MMP17
gene id: 9031:MMP17
uniprot id: A0A8V0ZTB2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9031:DNASE2B
gene id: 9031:DNASE2B
uniprot id: Q2XP49
names: Similarity
messages: Belongs to the DNase II family.

9031:MFN1
gene id: 9031:MFN1
uniprot id: Q5ZKH5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9031:MED20
gene id: 9031:MED20
uniprot id: Q5ZKY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

9031:C3orf70
gene id: 9031:C3orf70
uniprot id: A0A3Q2UF71
names: Similarity
messages: Belongs to the UPF0524 family.

9031:VPS50
gene id: 9031:VPS50
uniprot id: Q5ZKV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
messages: Belongs to the syndetin family.
messages: Component of the endosome-associated retrograde protein (EARP) complex.
messages: Membrane
messages: Recycling endosome

9031:FZD7
gene id: 9031:FZD7
uniprot id: O57329
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Expressed broadly in cranial ectoderm. Also expressed in the developing somites and in other cranial placodes, including the olfactory, lens, otic placodes (lateral half of the vesicle) and epibranchial placodes. Low level of expression in all the mesoderm derivatives in the limb buds.
messages: First detected as stage 6 in the forming neural tube and somites, but not in trunk surface ectoderm. By stage 8, expression persists in the cranial ectoderm and is up-regulated in the presomptive olfactory placodes. By stages 11-12, expression declines in the neural tube, but not in the cranial ectoderm; in somites, expressed all along the rostral-caudal axis as well as in presegmental mesenchyme caudal to the developing somites. Lens and otic placode expression first visible at stage 12, strongest at stages 13-16. Detected uniformly in ectoderm and mesenchyme of the limb primordia at stage 17. By stage 18, decrease of ectodermal, otic, lens and olfactory placode expression; expression appears in the epibranchial placodes. By stages 22-30, highest levels in the most distal mesoderm of the autopod, in the ventricular zone of the neural tube from the forebrain to the spinal cord, in the dermomyotomes and the tail buds.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
messages: The FZ domain is involved in binding with Wnt ligands.

9031:PHTF2
gene id: 9031:PHTF2
uniprot id: A0A8V0Y5R1
uniprot id: Q5ZKN3
names: Subcellular Location Annotation
messages: Membrane

9031:GAD1
gene id: 9031:GAD1
uniprot id: Q9YI58
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9031:EGFR
gene id: 9031:EGFR
uniprot id: A0A1D5PKH0
uniprot id: P13387
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation.
messages: Cell membrane
messages: Endocytosis and inhibition of the activated EGFR by phosphatases constitute immediate regulatory mechanisms. Moreover, inducible feedback inhibitors may constitute alternative regulatory mechanisms for the EGFR signaling.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Nucleus
messages: Nucleus membrane
messages: Phosphorylated. Autophosphorylates.
messages: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:3260329). Known ligands include EGF and TGFA/TGF-alpha (PubMed:3260329). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (By similarity). May also activate the NF-kappa-B signaling cascade (By similarity).

9031:TRAPPC6A
gene id: 9031:TRAPPC6A
uniprot id: E1C3X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9031:RIOK3
gene id: 9031:RIOK3
uniprot id: A0A8V0XND6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9031:UBE2H
gene id: 9031:UBE2H
uniprot id: Q5ZLI7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:OIP5
gene id: 9031:OIP5
uniprot id: E1BQA1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9031:RBM17
gene id: 9031:RBM17
uniprot id: A0A8V0XUL9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9031:GJB1
gene id: 9031:GJB1
uniprot id: Q6URH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:SCNN1G
gene id: 9031:SCNN1G
uniprot id: F1NW62
names: Subcellular Location Annotation
messages: Membrane

9031:S100A1
gene id: 9031:S100A1
uniprot id: A0A1D5PJJ4
names: Similarity
messages: Belongs to the S-100 family.

9031:EIF4A3
gene id: 9031:EIF4A3
uniprot id: Q5ZM36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with CASC3, MAGOH, NXF1, RBM8A and ALYREF/THOC4. May interact with NOM1. Interacts with POLDIP3. Interacts with CWC22 and PRPF19 in an RNA-independent manner. Direct interaction with CWC22 is mediated by the helicase C-terminal domain. Full interaction with CWC22 occurs only when EIF4A3 is not part of the EJC and prevents EIF4A3 binding to RNA. Interacts with NCBP3.
messages: Nucleus
messages: Nucleus speckle

9031:RPL7
gene id: 9031:RPL7
uniprot id: Q5ZJ56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
messages: Cytoplasm

9031:LHFPL5
gene id: 9031:LHFPL5
uniprot id: Q7ZZL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LHFP family.
messages: Cell membrane

9031:FOLR1
gene id: 9031:FOLR1
uniprot id: Q9PW81
names: Similarity
messages: Belongs to the folate receptor family.

9031:MAPK3
gene id: 9031:MAPK3
uniprot id: Q8UWG6
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9031:GPR83
gene id: 9031:GPR83
uniprot id: G3G8J1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:MIS18A
gene id: 9031:MIS18A
uniprot id: E1BQA3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9031:CCDC47
gene id: 9031:CCDC47
uniprot id: F1NL71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC47 family.
messages: Rough endoplasmic reticulum membrane

9031:OPRD1
gene id: 9031:OPRD1
uniprot id: A0A2Z2CIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:GPRC5B
gene id: 9031:GPRC5B
uniprot id: E1BT99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:ZIC5
gene id: 9031:ZIC5
uniprot id: A0A387J5I1
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9031:NOX4
gene id: 9031:NOX4
uniprot id: A7E3L2
names: Subcellular Location Annotation
messages: Membrane

9031:PPY
gene id: 9031:PPY
uniprot id: P68248
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions.
messages: Secreted

9031:NSF
gene id: 9031:NSF
uniprot id: E1BQU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9031:CAMK2D
gene id: 9031:CAMK2D
uniprot id: A0A8V0XB58
uniprot id: A0A8V0XB63
uniprot id: A0A8V0XMA9
uniprot id: A0A8V0XMB5
uniprot id: Q5ZKI0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits (By similarity).
messages: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system.

9031:ERBB4
gene id: 9031:ERBB4
uniprot id: A0A8V0YE48
uniprot id: Q4PLA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9031:ACBD5
gene id: 9031:ACBD5
uniprot id: Q5ZHQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity).
messages: Belongs to the ATG37 family.
messages: Peroxisome membrane

9031:MOGAT1
gene id: 9031:MOGAT1
uniprot id: A0A8V1A141
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SMARCA4
gene id: 9031:SMARCA4
uniprot id: Q90753
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9031:FICD
gene id: 9031:FICD
uniprot id: A0A8V0ZQ41
names: Similarity
messages: Belongs to the fic family.

9031:IRF2BP2
gene id: 9031:IRF2BP2
uniprot id: A0A8V0XZF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9031:DPYS
gene id: 9031:DPYS
uniprot id: A0A1D5PMN7
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

9031:CMC1
gene id: 9031:CMC1
uniprot id: R4GL82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9031:PER3
gene id: 9031:PER3
uniprot id: E1C8E2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:MTM1
gene id: 9031:MTM1
uniprot id: E1BRL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9031:ZPBP1
gene id: 9031:ZPBP1
uniprot id: F1NQ00
uniprot id: Q5F3P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted
messages: acrosome

9031:B3GALT6
gene id: 9031:B3GALT6
uniprot id: A0A8V0ZK44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:PTGR1
gene id: 9031:PTGR1
uniprot id: Q5ZII4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9031:RAD54L
gene id: 9031:RAD54L
uniprot id: O12944
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated. Acetylation promotes interaction with BRD9, and subsequently with RAD54, which is essential for homologous recombination (HR).
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Highly expressed in bursa, thymus, testis, and ovary. Low level of expression seen in all other organs tested.
messages: Homohexamer (By similarity). Interacts (via N-terminus) with RAD51 (By similarity). Interacts with NAP1L1 (By similarity). Interacts with BRD9; this interaction orchestrates RAD51-RAD54 complex formation (By similarity).
messages: Nucleus
messages: Phosphorylated. Phosphorylation at Ser-561 by NEK1 specifically in G2 phase allows efficient removal of RAD51 filaments from DNA.
messages: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA.

9031:UTS2
gene id: 9031:UTS2
uniprot id: Q6Q2J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9031:UBR2
gene id: 9031:UBR2
uniprot id: A0A1D5P284
uniprot id: E1C1D2
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9031:GID8
gene id: 9031:GID8
uniprot id: Q5ZKQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GID8 family.
messages: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation.
messages: Cytoplasm
messages: Homodimer; may also form higher oligomers (By similarity). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8. Interacts with CTNNB1, AXIN1 and GSK3B (By similarity).
messages: Nucleus

9031:RAB4A
gene id: 9031:RAB4A
uniprot id: A0A1D5NWR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9031:PHAX
gene id: 9031:PHAX
uniprot id: Q5ZLY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm
messages: Nucleus
messages: Probably involved in protein and RNA export from the nucleus.

9031:CENPN
gene id: 9031:CENPN
uniprot id: Q1T765
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-N/CHL4 family.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: centromere

9031:PARP3
gene id: 9031:PARP3
uniprot id: E1BSI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:27530147). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 (By similarity). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA (PubMed:27530147). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ (By similarity). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (By similarity). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (By similarity).
messages: Nucleus
messages: centriole
messages: centrosome

9031:ZDHHC23
gene id: 9031:ZDHHC23
uniprot id: Q5F493
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:GDPD5
gene id: 9031:GDPD5
uniprot id: A0A1D5NU41
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:KMT5B
gene id: 9031:KMT5B
uniprot id: E1C014
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9031:RPS26
gene id: 9031:RPS26
uniprot id: Q5ZM66
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9031:KCNJ3
gene id: 9031:KCNJ3
uniprot id: Q90854
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger (By similarity).
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat (By similarity).

9031:NPFFR1
gene id: 9031:NPFFR1
uniprot id: Q75XU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9031:NDE1
gene id: 9031:NDE1
uniprot id: Q5ZMC9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nudE family.
messages: Phosphorylated in mitosis.
messages: Required for centrosome duplication and formation and function of the mitotic spindle.
messages: Self-associates. Interacts with PAFAH1B1 (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

9031:CLIC5
gene id: 9031:CLIC5
uniprot id: A0A1D5PU60
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9031:SLC6A9
gene id: 9031:SLC6A9
uniprot id: Q5ZL10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9031:LGR5
gene id: 9031:LGR5
uniprot id: E1C2F8
names: Subcellular Location Annotation
messages: Membrane

9031:CHST4
gene id: 9031:CHST4
uniprot id: A0A8V0Y7L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9031:WDYHV1
gene id: 9031:WDYHV1
uniprot id: A0A1D5PW90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9031:PABIR2
gene id: 9031:PABIR2
uniprot id: E1C1H5
names: Similarity
messages: Belongs to the FAM122 family.

9031:ATP1B3
gene id: 9031:ATP1B3
uniprot id: P33879
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Predominantly expressed in brain.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
messages: Was originally thought to be the beta-2 subunit.

9031:MYBL2
gene id: 9031:MYBL2
uniprot id: Q03237
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the DREAM complex.
messages: Expressed in hematopoietic and non hematopoietic cells.
messages: Nucleus
messages: Represses v-myb- and c-myb-mediated activation of the mim-1 gene, probably by competing with other myb proteins for binding sites. It is an inhibitory member of the myb family.

9031:CYR61
gene id: 9031:CYR61
uniprot id: P19336
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: By V-Src.
messages: Probable secreted regulatory protein.
messages: Secreted

9031:LAMP5
gene id: 9031:LAMP5
uniprot id: A0A0B4J1C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Membrane

9031:TOP1
gene id: 9031:TOP1
uniprot id: P79994
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9031:TNFAIP8
gene id: 9031:TNFAIP8
uniprot id: Q5ZI78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative mediator of apoptosis.
messages: Belongs to the TNFAIP8 family.
messages: Cytoplasm

9031:MTF2
gene id: 9031:MTF2
uniprot id: Q6X7S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9031:LOC772096
gene id: 9031:LOC772096
uniprot id: C0J3M4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:DCAF13
gene id: 9031:DCAF13
uniprot id: Q5ZLK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Component of the DCX(DCAF13) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DCAF13 and RBX1.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex.
messages: nucleolus

9031:TMEM144
gene id: 9031:TMEM144
uniprot id: R4GLS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

9031:MTNR1A
gene id: 9031:MTNR1A
uniprot id: P49285
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in optic tectum and retina, less in neostriatum, hypothalamus and thalamus.
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).

9031:CAND1
gene id: 9031:CAND1
uniprot id: F1NHL2
names: Similarity
messages: Belongs to the CAND family.

9031:DGKD
gene id: 9031:DGKD
uniprot id: A0A8V0ZRE2
uniprot id: A0A8V0ZYX2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9031:THRB
gene id: 9031:THRB
uniprot id: F1NWE9
uniprot id: P68306
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus

9031:RNPEP
gene id: 9031:RNPEP
uniprot id: A0A8V1A0A4
uniprot id: A0A8V1AAK3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9031:STXBP1
gene id: 9031:STXBP1
uniprot id: A0A1D5PHU2
uniprot id: A0A1D5PK28
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9031:KCNS3
gene id: 9031:KCNS3
uniprot id: E1BWF1
names: Subcellular Location Annotation
messages: Membrane

9031:DRD3
gene id: 9031:DRD3
uniprot id: C5HV40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9031:SPON1
gene id: 9031:SPON1
uniprot id: Q9W770
names: Function
names: Subcellular Location Annotation
messages: Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Somite-derived spondin 1 is an inhibitory signal involved in patterning the segmental migration of neural crest cells and their topographical segregation within the rostral somites in vitro. May be required to prevent the lateral drifting of the commissural axons after having crossed the floor plate.
messages: extracellular matrix

9031:SPINK5
gene id: 9031:SPINK5
uniprot id: P10184
names: Allergen
names: Biotechnology
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Causes an allergic reaction in humans. Binds to IgE of egg-allergic patients. Immunoreactivity is lost by simulated gastric and gastroduodenal digestion (PubMed:23122126). Binds to rabbit anti-ovomucoid IgG antibody indicating the cross-reactivity between this protein and the ovomucoid protein from egg white (PubMed:6838526).
messages: Expressed in liver of pre-laying and egg-laying hens throughout sexual maturation. Expression increases gradually from 13 weeks of age reaching its maximum at 15 weeks of age (pre-laying hens). A significant decrease in expression is observed in 41-week-old hens (egg-laying), a level that is significantly lower than that measured initially in 13-week-old pullets.
messages: Expressed in oviduct (at protein level) (PubMed:3571241). Expressed in egg white (at protein level) (PubMed:6838526, PubMed:14519973, PubMed:23122126, PubMed:25436390). Expressed in egg yolk plasma of non-fertilized eggs (at protein level) (PubMed:22010862). Expressed in the magnum of the oviduct (at protein level) (PubMed:25436390). Expressed in oviduct (PubMed:3571241, PubMed:14609095). Expressed in liver (PubMed:3571241, PubMed:11572089, PubMed:22010862). Expressed in the cortico-medullary border region of the bursa of Fabricius by the bursal secretory dendritic-like cells (PubMed:15252730). Highly expressed in the magnum of the oviduct, and at a lower level in uterus. Weakly expressed in white isthmus and very weakly in infundibulum. Not expressed in duodenum and kidney (PubMed:22010862).
messages: Expression is regulated by dietary stress. Significantly increased expression between days 0 to 5 in egg whites of eggs laid by corticosterone-fed hens (at protein level). Decreased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens (PubMed:25436390). Significantly increased expression by estrogen. Rapidly up-regulated within 0.5 hour after extrogen exposure with a peak at 1-4 hours and diminishing thereafter (PubMed:11572089). Up-regulated during sexual maturation of pullets (PubMed:22010862).
messages: Glycosylated.
messages: Prevents symptomatic gastoroenteritis in vivo in a mouse model of rotavirus infection. Significantly inhibits intestinal replication of EDIM strain of murine rotavirus in infant mice up to 4 days after intragastrical administration of the virus.
messages: Secreted
messages: Seems to have at least five separate non-overlapping active inhibitory domains; two for trypsin, two for chymotrypsin and one for elastase. They can be bound to the domains simultaneously.
messages: Serine protease inhibitor involved in antimicrobial egg defense preventing contamination of table eggs (non-fertilized eggs) and protecting the chick embryo (fertilized eggs) (Probable). Inhibits trypsin, chymotrypsin, elastase, subtilisin and a proteinase of fungus Aspergillus oryzae (PubMed:13944692, PubMed:6904299, PubMed:6838526, PubMed:14519973, PubMed:14609095, PubMed:22010862). Inhibits calcium-activated potassium channels KCNMA1 (bovine) and slo (Drosophila) (PubMed:8973172). Has antibacterial activity against B.thuringiensis LMSA 3.06.004, but not against S.aureus CIP 103 811, P.aeruginosa PAO1, B.cereus ATCC6464 or B.subtilis ATCC 6633 (PubMed:22010862).
messages: The galactomannan conjugate of this protein prepared through the Maillard reaction shows almost the same inhibitory activity toward trypsin, chymotrypsin and elastase, with stronger heat and emulsion stability, and better emulsifying properties than the untreated protein. The conjugate can therefore be useful for industrial application.

9031:NRF1
gene id: 9031:NRF1
uniprot id: A0A3Q2U3T8
uniprot id: A0A8V0XI53
uniprot id: Q90979
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9031:RGS4
gene id: 9031:RGS4
uniprot id: Q7SZC6
names: Function
names: PTM
names: Tissue Specificity
messages: Expressed in the developing nervous system.
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).
messages: Palmitoylated on Cys-2 and/or Cys-12.
messages: Phosphorylated by cyclic GMP-dependent protein kinase.

9031:FUT9
gene id: 9031:FUT9
uniprot id: Q8UWC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9031:OLFM4
gene id: 9031:OLFM4
uniprot id: Q25C35
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:XCL1
gene id: 9031:XCL1
uniprot id: O57411
names: Similarity
messages: Belongs to the intercrine gamma family.

9031:ACADS
gene id: 9031:ACADS
uniprot id: Q5ZL56
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9031:HOOK1
gene id: 9031:HOOK1
uniprot id: Q5ZJ27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hook family.
messages: Cytoplasm
messages: Interacts with microtubules.
messages: May function to promote vesicle trafficking and/or fusion.
messages: cytoskeleton

9031:ETS2
gene id: 9031:ETS2
uniprot id: P10157
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Probable transcription factor.

9031:HIBADH
gene id: 9031:HIBADH
uniprot id: Q5ZLI9
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9031:NPM2
gene id: 9031:NPM2
uniprot id: A0A3Q2U959
names: Similarity
messages: Belongs to the nucleoplasmin family.

9031:LRP6
gene id: 9031:LRP6
uniprot id: A0A8V0ZKD5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:POU2F1
gene id: 9031:POU2F1
uniprot id: A0A8V0XSF4
uniprot id: P15143
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Interacts with NR3C1, AR and PGR.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity).

9031:ATXN3
gene id: 9031:ATXN3
uniprot id: A0A3Q2U0D7
uniprot id: Q9W689
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (By similarity). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Nucleus
messages: Nucleus matrix
messages: The UIM domains bind ubiquitin and interact with various E3 ubiquitin-protein ligase, such as STUB1/CHIP (By similarity). They are essential to limit the length of ubiquitin chains (By similarity).
messages: Widely expressed (PubMed:10023088).

9031:SUSD6
gene id: 9031:SUSD6
uniprot id: A0A1D5PFT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:WNT16
gene id: 9031:WNT16
uniprot id: R4GLW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:WISP1
gene id: 9031:WISP1
uniprot id: Q4ZJF1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:TSC22D4
gene id: 9031:TSC22D4
uniprot id: Q06AW4
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9031:TSHZ2
gene id: 9031:TSHZ2
uniprot id: F1NNH5
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

9031:TM2D2
gene id: 9031:TM2D2
uniprot id: A0A1D5P3V1
names: Subcellular Location Annotation
messages: Membrane

9031:HIST1H2B8
gene id: 9031:HIST1H2B8
uniprot id: Q9PSW9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:PDS5B
gene id: 9031:PDS5B
uniprot id: Q5F3U9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with the cohesin complex.
messages: Nucleus
messages: Plays a role in androgen-induced proliferative arrest. Required for maintenance of sister chromatid cohesion during mitosis (By similarity).

9031:TAF2
gene id: 9031:TAF2
uniprot id: A0A8V0Y3C6
uniprot id: Q5ZIT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF2 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs).
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs).

9031:GNG10
gene id: 9031:GNG10
uniprot id: E1C795
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9031:TOP3B
gene id: 9031:TOP3B
uniprot id: Q5ZK71
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9031:NCBP1
gene id: 9031:NCBP1
uniprot id: Q5ZJZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NCBP1 family.
messages: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. The conventional CBC with NCBP2 binds both small nucle…
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA. Component of an alternative nuclear cap-binding complex (CBC) composed of NCBP1/CBP80 and NCBP3 (By similarity).
messages: Cytoplasm
messages: Nucleus

9031:FBXO25
gene id: 9031:FBXO25
uniprot id: A0A1L1RPL7
uniprot id: A0A3Q2TVN9
names: Subcellular Location Annotation
messages: Nucleus

9031:LOC428335
gene id: 9031:LOC428335
uniprot id: Q5ZJK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9031:NRG4
gene id: 9031:NRG4
uniprot id: A0A8V0ZY13
uniprot id: Q5ZJR0
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TRAF2
gene id: 9031:TRAF2
uniprot id: A0A090JQG8
uniprot id: E1BTY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9031:NUP50
gene id: 9031:NUP50
uniprot id: Q5F473
names: Subcellular Location Annotation
messages: nuclear pore complex

9031:NPEPL1
gene id: 9031:NPEPL1
uniprot id: F1NSZ4
names: Similarity
messages: Belongs to the peptidase M17 family.

9031:CENPI
gene id: 9031:CENPI
uniprot id: Q8AYS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-I/CTF3 family.
messages: Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for the localization of CENPC but not CENPA to the centromere. It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
messages: Component of the CENPA-HI complex, at least composed of CENPH, CENPI, CENPK, CENPL, CENPM, CENPO and CENPP.
messages: Nucleus
messages: centromere

9031:RBP4
gene id: 9031:RBP4
uniprot id: P08938
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: May be involved in the transport of retinol between the photoreceptors and the pigmented epithelium.
messages: interphotoreceptor matrix

9031:ADCYAP1
gene id: 9031:ADCYAP1
uniprot id: Q58FG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9031:NUDC
gene id: 9031:NUDC
uniprot id: Q5ZIN1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity).
messages: Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation is necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity).
messages: cytoskeleton
messages: spindle

9031:ADGRG6
gene id: 9031:ADGRG6
uniprot id: F1P1B2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:FOXK1
gene id: 9031:FOXK1
uniprot id: A0A8V0ZAU7
names: Subcellular Location Annotation
messages: Nucleus

9031:ULK3
gene id: 9031:ULK3
uniprot id: A0A8V1A0W4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:GR42L5
gene id: 9031:GR42L5
uniprot id: I3RLD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:TBX3
gene id: 9031:TBX3
uniprot id: A0A1D5NXF3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:RPL12
gene id: 9031:RPL12
uniprot id: E1BTG1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9031:PANK4
gene id: 9031:PANK4
uniprot id: A0A8V0Z4N5
names: Similarity
names: Subunit
messages: Belongs to the type II pantothenate kinase family.
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.

9031:DCTN4
gene id: 9031:DCTN4
uniprot id: E1BQQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: cell cortex
messages: centrosome
messages: sarcomere
messages: stress fiber

9031:HOXB13
gene id: 9031:HOXB13
uniprot id: A0A8V1AAB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9031:SGMS2
gene id: 9031:SGMS2
uniprot id: F1NLG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9031:PRDM16
gene id: 9031:PRDM16
uniprot id: A0A3Q3AHL1
names: Subcellular Location Annotation
messages: Nucleus

9031:HIKESHI
gene id: 9031:HIKESHI
uniprot id: Q5ZK09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages (By similarity).
messages: Belongs to the OPI10 family.
messages: Nucleus
messages: cytosol

9031:STXBP5
gene id: 9031:STXBP5
uniprot id: A0A3Q2UIP6
uniprot id: A0A3Q3AJI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9031:CCPG1
gene id: 9031:CCPG1
uniprot id: Q5ZM60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCPG1 family.
messages: Cytoplasmic granule membrane
messages: May be involved in the regulation of Rho-mediated signaling pathways and in cell cycle regulation.

9031:TMEM41A
gene id: 9031:TMEM41A
uniprot id: A0A1D5PJ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9031:RAPGEF6
gene id: 9031:RAPGEF6
uniprot id: A0A8V0YWD7
names: Similarity
messages: Belongs to the RAPGEF2 family.

9031:UBA52
gene id: 9031:UBA52
uniprot id: O42388
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

9031:NR1I3
gene id: 9031:NR1I3
uniprot id: Q9DFH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus

9031:PRICKLE1
gene id: 9031:PRICKLE1
uniprot id: F1P3B6
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9031:PAAF1
gene id: 9031:PAAF1
uniprot id: Q5ZK69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat PAAF1/RPN14 family.
messages: Inhibits proteasome 26S assembly and activity by impairing the association of the 19S regulatory complex with the 20S core.
messages: Interacts with proteasome 26S subunit ATPases.

9031:FAM126A
gene id: 9031:FAM126A
uniprot id: Q5ZM13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis.
messages: Component of a phosphatidylinositol 4-kinase (PI4K) complex.
messages: cytosol

9031:PAIP2B
gene id: 9031:PAIP2B
uniprot id: Q5ZJS6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity).
messages: Belongs to the PAIP2 family.
messages: Cytoplasm
messages: Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9031:MSI2
gene id: 9031:MSI2
uniprot id: A0A8V1AKK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm

9031:PDIK1L
gene id: 9031:PDIK1L
uniprot id: A0A8V0Z2E3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:SRXN1
gene id: 9031:SRXN1
uniprot id: A0A3Q2UDS8
names: Similarity
messages: Belongs to the sulfiredoxin family.

9031:GPSM2
gene id: 9031:GPSM2
uniprot id: E1BR28
names: Similarity
messages: Belongs to the GPSM family.

9031:DIPK2A
gene id: 9031:DIPK2A
uniprot id: A0A3Q2U652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9031:UBA3
gene id: 9031:UBA3
uniprot id: A0A8V0ZBK2
uniprot id: A0A8V0ZCG1
uniprot id: E1BT61
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9031:KIF20A
gene id: 9031:KIF20A
uniprot id: Q5ZKH9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:EIF3B
gene id: 9031:EIF3B
uniprot id: A0A8V0ZC55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

9031:HPGD
gene id: 9031:HPGD
uniprot id: E1C688
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:GSPT2
gene id: 9031:GSPT2
uniprot id: A0A1D5PYQ3
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9031:DUSP6
gene id: 9031:DUSP6
uniprot id: Q7T2L9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9031:IER3IP1
gene id: 9031:IER3IP1
uniprot id: A0A1D5PTS3
names: Similarity
messages: Belongs to the YOS1 family.

9031:MRPS25
gene id: 9031:MRPS25
uniprot id: E1BSI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9031:TJP2
gene id: 9031:TJP2
uniprot id: A0A8V0Z002
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9031:PDE7B
gene id: 9031:PDE7B
uniprot id: A0A3Q2TZX9
uniprot id: A0A3Q2UQ10
uniprot id: F1NVY7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:WSCD2
gene id: 9031:WSCD2
uniprot id: A0A8V0ZV87
names: Function
names: Similarity
messages: Belongs to the WSCD family.
messages: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.

9031:HDAC1
gene id: 9031:HDAC1
uniprot id: P56517
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Also functions as deacetylase for non-histone proteins. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (By similarity).
messages: Nucleus

9031:RAD21
gene id: 9031:RAD21
uniprot id: Q5ZLK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9031:PNPLA4
gene id: 9031:PNPLA4
uniprot id: B3TZB7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TMEM63A
gene id: 9031:TMEM63A
uniprot id: F1P4T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9031:CKMT2
gene id: 9031:CKMT2
uniprot id: F1NAD3
uniprot id: P11009
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Exists as an octamer composed of four MTCK homodimers.
messages: Expressed in the leg muscle and heart.
messages: Mitochondrial creatine kinase binds cardiolipin.
messages: Mitochondrion inner membrane
messages: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

9031:CLCN7
gene id: 9031:CLCN7
uniprot id: Q5ZL60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9031:MRPS26
gene id: 9031:MRPS26
uniprot id: Q2ACD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9031:UTP3
gene id: 9031:UTP3
uniprot id: A0A3Q2U489
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

9031:TGFBR1
gene id: 9031:TGFBR1
uniprot id: Q06900
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9031:HIST1H2A4L4
gene id: 9031:HIST1H2A4L4
uniprot id: P02263
uniprot id: Q92069
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).
messages: Monoubiquitination of Lys-120 (H2AK119Ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties, leading to the recruitment of repair proteins to sites of DNA damage. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:LOC100857940
gene id: 9031:LOC100857940
uniprot id: A0A1D5P6V7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:MLH1
gene id: 9031:MLH1
uniprot id: A0A1D5P146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9031:PREP
gene id: 9031:PREP
uniprot id: Q5ZMI7
names: Similarity
messages: Belongs to the peptidase S9A family.

9031:SRP72
gene id: 9031:SRP72
uniprot id: Q5ZKZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

9031:YEATS4
gene id: 9031:YEATS4
uniprot id: Q8UVS4
names: Subcellular Location Annotation
messages: Nucleus

9031:AMDHD1
gene id: 9031:AMDHD1
uniprot id: F1P298
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

9031:TMEM19
gene id: 9031:TMEM19
uniprot id: A0A8V0YIP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9031:TBPL2
gene id: 9031:TBPL2
uniprot id: A6H910
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9031:PGAM1
gene id: 9031:PGAM1
uniprot id: Q5ZLN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate.
messages: Homodimer.

9031:SLCO1C1
gene id: 9031:SLCO1C1
uniprot id: Q2PGG8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:PTGR2
gene id: 9031:PTGR2
uniprot id: A0A8V0Z902
uniprot id: Q5F370
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9031:RPLP1
gene id: 9031:RPLP1
uniprot id: P18660
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9031:PTGER2
gene id: 9031:PTGER2
uniprot id: A2TH15
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:PRIM2
gene id: 9031:PRIM2
uniprot id: Q5ZM06
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.

9031:GORASP1
gene id: 9031:GORASP1
uniprot id: Q5ZK65
names: Similarity
messages: Belongs to the GORASP family.

9031:APPL2
gene id: 9031:APPL2
uniprot id: A0A8V0YBR8
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9031:CD8A
gene id: 9031:CD8A
uniprot id: Q90770
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:GABRQ
gene id: 9031:GABRQ
uniprot id: P24045
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB4 sub-subfamily.
messages: Cell membrane
messages: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
messages: Postsynaptic cell membrane

9031:DDX3X
gene id: 9031:DDX3X
uniprot id: A0A8V0XGV3
uniprot id: Q5F491
names: Similarity
messages: Belongs to the DEAD box helicase family.

9031:RNASE6
gene id: 9031:RNASE6
uniprot id: P27043
uniprot id: Q27J91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pancreatic ribonuclease family.
messages: Homodimer. Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur (By similarity).
messages: Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
messages: Secreted
messages: nucleolus
messages: secretory vesicle lumen

9031:HMGA2
gene id: 9031:HMGA2
uniprot id: O73816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9031:GBGT1
gene id: 9031:GBGT1
uniprot id: Q5ZLK4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Golgi apparatus membrane
messages: May catalyze the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens (By similarity).
messages: The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).

9031:TCEB3
gene id: 9031:TCEB3
uniprot id: Q5ZID8
names: Subcellular Location Annotation
messages: Nucleus

9031:SPOUT1
gene id: 9031:SPOUT1
uniprot id: A0A8V1AEU1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

9031:C7orf25
gene id: 9031:C7orf25
uniprot id: A0A1D5P7R3
uniprot id: A0A3Q3AZZ9
names: Similarity
messages: Belongs to the UPF0415 family.

9031:TNK2
gene id: 9031:TNK2
uniprot id: A0A8V0YRC4
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9031:NCAPD2
gene id: 9031:NCAPD2
uniprot id: Q5F475
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

9031:NR2C1
gene id: 9031:NR2C1
uniprot id: Q8JID3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:B4GALTL
gene id: 9031:B4GALTL
uniprot id: A0A1L1RXH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:FBXO45
gene id: 9031:FBXO45
uniprot id: A0A8V1A7G4
names: Similarity
messages: Belongs to the FBXO45/Fsn family.

9031:FGF19
gene id: 9031:FGF19
uniprot id: R4GMB5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:TYW3
gene id: 9031:TYW3
uniprot id: A0A1D5PIG9
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9031:INO80D
gene id: 9031:INO80D
uniprot id: A0A1D5P5H5
names: Subcellular Location Annotation
messages: Nucleus

9031:PRLL
gene id: 9031:PRLL
uniprot id: C6ZDB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9031:VPS33B
gene id: 9031:VPS33B
uniprot id: A0A3S5ZPB6
uniprot id: Q5ZL71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9031:EYA4
gene id: 9031:EYA4
uniprot id: Q9YH98
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).

9031:MGST1
gene id: 9031:MGST1
uniprot id: B4X9P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9031:ID3
gene id: 9031:ID3
uniprot id: Q90X14
names: Subcellular Location Annotation
messages: Nucleus

9031:CHURC1
gene id: 9031:CHURC1
uniprot id: Q9DFZ3
names: Function
names: Similarity
messages: Belongs to the Churchill family.
messages: Transcriptional activator that mediates FGF signaling during neural development (PubMed:14651851). Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself (By similarity).

9031:CDC42
gene id: 9031:CDC42
uniprot id: A0A1D5PD33
uniprot id: Q90694
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
messages: centrosome
messages: dendrite
messages: spindle

9031:CENPO
gene id: 9031:CENPO
uniprot id: Q1T7B8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-O/MCM21 family.
messages: Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). Involved in kinetochore assembly and required for recovery from spindle damage.
messages: Component of the CENPA-HI complex, at least composed of CENPH, CENPI, CENPK, CENPL, CENPM, CENPO and CENPP. Component of a discrete complex composed of at least CENPO, CENPP, CENPQ, CENPR and CENPU.
messages: Increases time to progress through G2/M phase.
messages: Nucleus
messages: centromere

9031:L3MBTL2
gene id: 9031:L3MBTL2
uniprot id: A0A3Q2UEH2
uniprot id: Q5ZLC2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

9031:GOLPH3
gene id: 9031:GOLPH3
uniprot id: R4GJZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9031:HSPA13
gene id: 9031:HSPA13
uniprot id: Q5F497
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9031:GSKIP
gene id: 9031:GSKIP
uniprot id: Q5ZMC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSKIP family.
messages: Cytoplasm

9031:IL7R
gene id: 9031:IL7R
uniprot id: A1EA95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

9031:MTMR9
gene id: 9031:MTMR9
uniprot id: Q5F3L6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9031:PRKRIP1
gene id: 9031:PRKRIP1
uniprot id: Q5ZKU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRKRIP1 family.
messages: Component of the pre-catalytic and post-catalytic spliceosome complexes.
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA (By similarity).
messages: nucleolus

9031:SELENOW
gene id: 9031:SELENOW
uniprot id: D0EYG3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SelWTH family. Selenoprotein W subfamily.
messages: Cytoplasm
messages: Expressed ubiquitously with predominant expression in the pituitary, spinal cord, sciatic nerve, cerebral cortex, cerebral nuclei, thalamus, cerebellum, muscle, cartilage, trachea, gizzard and artery. Weakly expressed in pancreas, testis, ovary, kidney and veins.
messages: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).
messages: Up-regulated by dietary selenium in cerebral tissue.

9031:GAD2
gene id: 9031:GAD2
uniprot id: A0A1D5PLC8
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9031:PPIP5K2
gene id: 9031:PPIP5K2
uniprot id: A0A1D5P1M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9031:KAT7
gene id: 9031:KAT7
uniprot id: Q5ZK16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9031:NKX2-1
gene id: 9031:NKX2-1
uniprot id: Q9YH59
names: Subcellular Location Annotation
messages: Nucleus

9031:TEX10
gene id: 9031:TEX10
uniprot id: Q5ZM41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of some MLL1/MLL complex. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.
messages: Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

9031:DCK
gene id: 9031:DCK
uniprot id: Q5ZMF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DCK/DGK family.
messages: Expressed at high levels in adult intestine, spleen, thymus and testis with lower levels in skeletal muscle and eye. In the embryo, expressed at higher levels until day 10 with lower levels in later stages.
messages: Homodimer.
messages: Nucleus
messages: Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:27906638). Displays highest activity against deoxycytidine followed by deoxyadenosine and then deoxyguanosine (PubMed:27906638). Shows only very minor activity against deoxyuridine and deoxythymidine (PubMed:27906638).

9031:CYP26B1
gene id: 9031:CYP26B1
uniprot id: F1NZL3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:CHRDL2
gene id: 9031:CHRDL2
uniprot id: A0A8V0XD57
uniprot id: A0A8V0XDK5
names: Subcellular Location Annotation
messages: Secreted

9031:MARCH5
gene id: 9031:MARCH5
uniprot id: Q5ZJ41
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control.
messages: Mitochondrion outer membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

9031:EZR
gene id: 9031:EZR
uniprot id: Q9YGW6
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9031:ZNF326
gene id: 9031:ZNF326
uniprot id: A0A8V0ZRL1
uniprot id: Q5ZJ02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AKAP95 family.
messages: Component of the DBIRD complex.
messages: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing.
messages: Nucleus

9031:PDXP
gene id: 9031:PDXP
uniprot id: F1NC58
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

9031:NELL2
gene id: 9031:NELL2
uniprot id: Q90827
names: Tissue Specificity
messages: Strongly expressed in early embryonic neural tissues (brain, spinal cord, dorsal root ganglia); less in other tissues such as cells around cartilage, myocardium, lung mesenchymal cells, and liver. After hatching expression is restricted to neural tissues including retina.

9031:SH3RF2
gene id: 9031:SH3RF2
uniprot id: A0A1L1RP76
names: Similarity
messages: Belongs to the SH3RF family.

9031:HIP1R
gene id: 9031:HIP1R
uniprot id: Q5ZJZ1
names: Similarity
messages: Belongs to the SLA2 family.

9031:PKP3
gene id: 9031:PKP3
uniprot id: A0A8V0ZFK0
names: Similarity
messages: Belongs to the beta-catenin family.

9031:MARCKSL1
gene id: 9031:MARCKSL1
uniprot id: Q5ZKS0
names: Similarity
messages: Belongs to the MARCKS family.

9031:TMEM200A
gene id: 9031:TMEM200A
uniprot id: E1BT36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9031:RPL8
gene id: 9031:RPL8
uniprot id: F1NIX0
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9031:COLEC11
gene id: 9031:COLEC11
uniprot id: Q2LK94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the COLEC10/COLEC11 family.
messages: Expressed in the tongue, crop, crop mucosa, coprodeum, urodeum, proctoderm, colon, lung, ovary, uterus, testis, vitelline membrane, kidney, ureter, liver and skin.
messages: Homotrimer; disulfide-linked. Interacts with MASP1; probably triggers the lectin pathway of complement.
messages: Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.
messages: Secreted

9031:SAR1B
gene id: 9031:SAR1B
uniprot id: Q5ZKG0
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9031:SRP9
gene id: 9031:SRP9
uniprot id: Q5ZHT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9031:LLPH
gene id: 9031:LLPH
uniprot id: Q5ZHK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the learning-associated protein family.
messages: Chromosome
messages: Regulates dendritic and spine growth and synaptic transmission.
messages: nucleolus

9031:BTG1L
gene id: 9031:BTG1L
uniprot id: F1NFU7
names: Similarity
messages: Belongs to the BTG family.

9031:CRIPT
gene id: 9031:CRIPT
uniprot id: Q5ZKB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: Belongs to the CRIPT family.
messages: Component of the minor spliceosome, which splices U12-type introns.
messages: Cytoplasm

9031:E2F6
gene id: 9031:E2F6
uniprot id: E1C979
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9031:NEGR1
gene id: 9031:NEGR1
uniprot id: Q9W6V2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. IgLON family.
messages: Cell membrane
messages: Expressed in embryonic retina, telencephalon, tectum, cerebellum and diencephalon (at protein level).
messages: Glycosylated.
messages: Interacts with CEPU-1 and LAMP.
messages: May be involved in cell-adhesion. May participate in the regulation of neurite outgrowth in the developing brain.

9031:CPA1
gene id: 9031:CPA1
uniprot id: Q8UUK1
names: Similarity
messages: Belongs to the peptidase M14 family.

9031:MEGF10
gene id: 9031:MEGF10
uniprot id: E1C393
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ITPK1
gene id: 9031:ITPK1
uniprot id: Q5F480
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ITPK1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis.
messages: Monomer.

9031:BTG1
gene id: 9031:BTG1
uniprot id: P34743
names: Developmental Stage
names: Function
names: Similarity
messages: Anti-proliferative protein.
messages: Belongs to the BTG family.
messages: Its expression is associated with the early G1 phase of the cell cycle.

9031:TEKT3
gene id: 9031:TEKT3
uniprot id: E1BZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

9031:EARS2
gene id: 9031:EARS2
uniprot id: Q5ZJ66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Mitochondrion matrix

9031:DFNA5
gene id: 9031:DFNA5
uniprot id: Q5ZJ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9031:SRPRB
gene id: 9031:SRPRB
uniprot id: Q5ZJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:PQLC1
gene id: 9031:PQLC1
uniprot id: A0A3Q2U1K3
uniprot id: A0A8V0Y176
names: Subcellular Location Annotation
messages: Membrane

9031:UNC119B
gene id: 9031:UNC119B
uniprot id: A0A8V0ZK85
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9031:CTNND1
gene id: 9031:CTNND1
uniprot id: A0A3Q2U1A5
uniprot id: A0A8V1A0C3
names: Similarity
messages: Belongs to the beta-catenin family.

9031:CHGB
gene id: 9031:CHGB
uniprot id: A0A8V0YU88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9031:DGKZ
gene id: 9031:DGKZ
uniprot id: Q5F494
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9031:EXOSC2
gene id: 9031:EXOSC2
uniprot id: A0A1L1RZU7
uniprot id: Q5ZHN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9031:ATP6V1B2
gene id: 9031:ATP6V1B2
uniprot id: A0A1D5PP57
uniprot id: Q9I8A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9031:LOC769486
gene id: 9031:LOC769486
uniprot id: R4GLL2
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:RBFOX1
gene id: 9031:RBFOX1
uniprot id: A0A8V0Z8R7
uniprot id: A0A8V0Z8T7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9031:PPP2R5A
gene id: 9031:PPP2R5A
uniprot id: E1C5A3
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

9031:TSPAN2
gene id: 9031:TSPAN2
uniprot id: E1C2R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:SELENOI
gene id: 9031:SELENOI
uniprot id: Q5ZLL3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9031:STOML3
gene id: 9031:STOML3
uniprot id: F1P588
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9031:THPO
gene id: 9031:THPO
uniprot id: Q6IYE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9031:GSL
gene id: 9031:GSL
uniprot id: F1P0D2
names: Similarity
messages: Belongs to the glutamine synthetase family.

9031:RMI1
gene id: 9031:RMI1
uniprot id: Q5ZHV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RMI1 family.
messages: Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).
messages: Nucleus

9031:OSTC
gene id: 9031:OSTC
uniprot id: Q5ZJR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: Specific component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex.

9031:HMGCL
gene id: 9031:HMGCL
uniprot id: A0A1L1RJ90
uniprot id: A0A8V0YS55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9031:VLDLR
gene id: 9031:VLDLR
uniprot id: A0A8V0Y6D2
uniprot id: P98165
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in oocytes; much less in heart and skeletal muscle.
messages: Homooligomer. Binds to the extracellular matrix protein Reelin/RELN. Interacts with LRP8 (By similarity). Interacts with LDLRAP1 (By similarity). Interacts with SNX17 (By similarity). Interacts with DAB1. Interacts with PCSK9. Interacts with PAFAH1B3 and PAFAH1B2, the catalytic complex of (PAF-AH (I)) heterotetrameric enzyme; these interactions may modulate the Reelin pathway. Interacts with STX5; this interaction mediates VLDLR translocation from the endoplasmic reticulum to the plasma membrane. Interacts with CLU (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).
messages: clathrin-coated pit

9031:MARCO
gene id: 9031:MARCO
uniprot id: Q9I8D5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:TLE1
gene id: 9031:TLE1
uniprot id: A0A1D5P5C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9031:SLCO2A1
gene id: 9031:SLCO2A1
uniprot id: E5L948
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:CAPZB
gene id: 9031:CAPZB
uniprot id: P14315
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization.
messages: Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain.
messages: I band
messages: Isoform 1 is detected in pectoral muscle, cardiac muscle and gizzard. Isoform 2 is detected in brain and liver (at protein level). Isoform 2 is the predominant isoform of nonmuscle tissues and isoform 1 is the predominant isoform of muscle tissues.
messages: Z line
messages: cytoskeleton

9031:POT1
gene id: 9031:POT1
uniprot id: P62597
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the telombin family.
messages: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex that is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Binds to at least two telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand). Its activity is TERT dependent but it does not increase TERT activity (By similarity).
messages: Homodimer or homooligomer. Component of the telomerase ribonucleoprotein complex. Binds single-stranded telomeric DNA as a monomer (By similarity). Found in a complex with TERF1, TINF2 and TNKS1. Interacts with TNKS1 (By similarity).
messages: Nucleus
messages: telomere

9031:GSTA3
gene id: 9031:GSTA3
uniprot id: Q08392
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Alpha family.
messages: Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid.
messages: Homodimer or heterodimer of GSTA1 and GSTA2.

9031:PELI2
gene id: 9031:PELI2
uniprot id: F1NF65
names: Similarity
messages: Belongs to the pellino family.

9031:SULT4A1
gene id: 9031:SULT4A1
uniprot id: E1C8B2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:MDH1B
gene id: 9031:MDH1B
uniprot id: E1BQM3
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9031:EFNB1
gene id: 9031:EFNB1
uniprot id: A0A8V0YNS9
uniprot id: O73612
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ephrin family.
messages: Binds to the receptor tyrosine kinase EPHB2. Interacts with GRIP1 and GRIP2 (By similarity).
messages: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
messages: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:CNIH1
gene id: 9031:CNIH1
uniprot id: Q401B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9031:PRC1
gene id: 9031:PRC1
uniprot id: Q5F490
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

9031:MTMR8
gene id: 9031:MTMR8
uniprot id: Q5F452
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Nucleus envelope
messages: Phosphatase that acts on lipids with a phosphoinositol headgroup (By similarity). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).

9031:MYSM1
gene id: 9031:MYSM1
uniprot id: Q5F3F2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.
messages: Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA (By similarity).
messages: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
messages: Nucleus

9031:THRA
gene id: 9031:THRA
uniprot id: P04625
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus
messages: Probably interacts with SFPQ.

9031:ATF2
gene id: 9031:ATF2
uniprot id: O93602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Heterodimerization is essential for its transcriptional activity (By similarity).
messages: Cytoplasm
messages: Mitochondrion outer membrane
messages: Nucleus
messages: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3') (By similarity).

9031:HTRA1
gene id: 9031:HTRA1
uniprot id: A0A8V0XCM5
names: Similarity
messages: Belongs to the peptidase S1C family.

9031:FAM32A
gene id: 9031:FAM32A
uniprot id: A0A1D5PDZ1
names: Similarity
messages: Belongs to the FAM32 family.

9031:INTS11
gene id: 9031:INTS11
uniprot id: Q5ZIH0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Belongs to the multiprotein complex Integrator.
messages: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Mediates the snRNAs 3' cleavage.
messages: Nucleus
messages: The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.

9031:KDM5B
gene id: 9031:KDM5B
uniprot id: Q5F3R2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JARID1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Both the JmjC domain and the JmjN domain are required for enzymatic activity (By similarity). However ARID and PHD-type 1 domain are not required for activity per se but contributed to recognition of the H3(1-21)K4me2 substrate peptide (By similarity).
messages: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor. May repress the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
messages: Nucleus
messages: The 2 first PHD-type zinc finger domains are required for transcription repression activity.

9031:SLC39A13
gene id: 9031:SLC39A13
uniprot id: Q5ZI20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol.
messages: Golgi apparatus membrane
messages: Homodimer.

9031:TNFRSF25
gene id: 9031:TNFRSF25
uniprot id: A0A8V0Z929
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:FGR
gene id: 9031:FGR
uniprot id: Q02977
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: May participate in signaling pathways.
messages: Phosphorylated.
messages: There are elevated levels of this protein in neural and hematopoietic tissues.

9031:TGFB3
gene id: 9031:TGFB3
uniprot id: P16047
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide: Interacts with Transforming growth factor beta-3 (TGF-beta-3) chain; interaction is non-covalent and maintains (TGF-beta-3) in a latent state (By similarity). Latency-associated peptide: Interacts (via cell attachment site) with integrins, leading to release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-3: Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
messages: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity).
messages: Secreted
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: Transforming growth factor beta-3 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-3 (TGF-beta-3) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-3 inactive.
messages: Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).
messages: extracellular matrix

9031:SLC7A6
gene id: 9031:SLC7A6
uniprot id: A0A8V0ZQV6
names: Subcellular Location Annotation
messages: Membrane

9031:BORCS5
gene id: 9031:BORCS5
uniprot id: A0A1D5P955
uniprot id: Q5ZJA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9031:MARCH4
gene id: 9031:MARCH4
uniprot id: A0A1D5PG09
names: Subcellular Location Annotation
messages: Membrane

9031:AANAT
gene id: 9031:AANAT
uniprot id: P79774
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the acetyltransferase family. AANAT subfamily.
messages: Catalyzes the N-acetylation of serotonin into N-acetylserotonin.
messages: Cytoplasm
messages: Exhibits circadian rhythm pattern in the pineal gland with highest levels at ZT 24. Expression in the retinal photoreceptor cells oscillates in a circadian manner.
messages: Expressed in follicular pineal cells and retinal photoreceptors with five times more expression in the pineal gland.
messages: Monomer (By similarity). Interacts with YWHAZ; the interaction requires phosphorylation on Thr-29, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-203 site, the other ywhaz monomer with similar effect (By similarity).
messages: Phosphorylated; cAMP-dependent phosphorylation on both N-terminal and C-terminal sites regulates AANAT activity through allowing interaction with 14-3-3 proteins and protecting the enzyme against proteasomal degradation.

9031:ACAD9
gene id: 9031:ACAD9
uniprot id: Q5ZJ68
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9031:PRKAA1
gene id: 9031:PRKAA1
uniprot id: Q2PUH1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9031:EDN3
gene id: 9031:EDN3
uniprot id: A0A4P9IUQ8
uniprot id: A0A8V0YVB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9031:KITLG
gene id: 9031:KITLG
uniprot id: Q009U4
uniprot id: Q009U6
uniprot id: Q09108
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form is produced by proteolytic processing of the extracellular domain.
messages: Acts in the early stages of hematopoiesis.
messages: Belongs to the SCF family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity).
messages: Secreted
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9031:MED31
gene id: 9031:MED31
uniprot id: A0A1D5PK99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:GJB6
gene id: 9031:GJB6
uniprot id: O93533
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Exclusively expressed in the cochlea of the inner ear, where it is found in cells of the tegmentum vasculosum, cuboidal cells, supporting cells and clear cells.
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: Specifically expressed at the late developmental stages in the cochlea.
messages: gap junction

9031:MYO1A
gene id: 9031:MYO1A
uniprot id: A0A1D5PQB7
uniprot id: P47807
names: Caution
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Could play an important role in morphogenesis and function of intestinal microvilli.
messages: Intestine.
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).

9031:MELK
gene id: 9031:MELK
uniprot id: Q5ZL85
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9031:SEC61B
gene id: 9031:SEC61B
uniprot id: F1NWX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9031:UGT8
gene id: 9031:UGT8
uniprot id: Q98TB5
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9031:AGPAT3
gene id: 9031:AGPAT3
uniprot id: A0A1D5PUB7
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9031:CACHD1
gene id: 9031:CACHD1
uniprot id: F1NML1
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9031:FAXC
gene id: 9031:FAXC
uniprot id: E1C3J5
names: Similarity
messages: Belongs to the FAX family.

9031:POLRMT
gene id: 9031:POLRMT
uniprot id: E1BZ13
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9031:BACE1
gene id: 9031:BACE1
uniprot id: F1N916
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: trans-Golgi network

9031:RNF166
gene id: 9031:RNF166
uniprot id: Q5F3B2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates.

9031:ANKRD17
gene id: 9031:ANKRD17
uniprot id: A0A8V0XMM8
names: Subcellular Location Annotation
messages: Cytoplasm

9031:MPP7
gene id: 9031:MPP7
uniprot id: A0A3Q2U7N0
uniprot id: A0A8V0XMN6
uniprot id: A0A8V0XQF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9031:ING1
gene id: 9031:ING1
uniprot id: A0A1D5PZI6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9031:KCNMA1
gene id: 9031:KCNMA1
uniprot id: A0A8V0ZGW8
uniprot id: A0A8V0ZM88
uniprot id: A0A8V0ZNZ2
uniprot id: A0A8V0ZUL3
uniprot id: Q8AYS8
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation (By similarity).
messages: Homotetramer; which constitutes the calcium-activated potassium channel.
messages: It is uncertain whether Met-1 is the initiator or if the sequence starts further upstream.
messages: Membrane
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
messages: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).
messages: The S0 segment is essential for the modulation by the accessory beta subunits.
messages: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensor regions required for activation of the channel.
messages: The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation (By similarity).
messages: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).
messages: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca(2+) and Mg(2+).

9031:SUPT5H
gene id: 9031:SUPT5H
uniprot id: Q5ZI08
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT5 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (By similarity).
messages: Interacts with SUPT4H1 to form DSIF. DSIF interacts with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (CCNT1 or CCNT2). DSIF interacts with RNA polymerase II, and this interaction is reduced by phosphorylation of the C-terminal domain (CTD) of POLR2A by P-TEFb. DSIF also interacts with the NELF complex, which is composed of WHSC2/NELFA, COBRA1/NELFB, TH1L/NELFD and RDBP/NELFE, and this interaction occurs following prior binding of DSIF to RNA polymerase II. Also interacts with SUPT6H (By similarity).
messages: Nucleus
messages: Phosphorylated. Phosphorylation by P-TEFb alleviates transcriptional pausing. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly in mitosis (By similarity).

9031:RBP
gene id: 9031:RBP
uniprot id: A0A140T8H8
uniprot id: P02752
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Belongs to the folate receptor family.
messages: Plasma RBP has the same C-terminal sequence as the egg-white RBP, which suggests that the C-terminal residues are cleaved off upon incorporation into the oocyte.
messages: Plasma and yolk RBPS have the same carbohydrate components, whereas egg-white RBP has a different, ovomucoid-type carbohydrate chain.
messages: Required for the transport of riboflavin to the developing oocyte.
messages: Yolk RBP is synthesized in the liver; egg-white RBP is synthesized in the oviduct.

9031:PLAT
gene id: 9031:PLAT
uniprot id: E1C209
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:CDK8
gene id: 9031:CDK8
uniprot id: A0A8V0XNJ2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:LOC378902
gene id: 9031:LOC378902
uniprot id: Q7T3M7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CLTC
gene id: 9031:CLTC
uniprot id: A0A8V1ABS2
uniprot id: Q8UUR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9031:DCBLD2
gene id: 9031:DCBLD2
uniprot id: Q5F3F4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:NDUFB2
gene id: 9031:NDUFB2
uniprot id: A0A1D5PRB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:MCM5
gene id: 9031:MCM5
uniprot id: Q5ZKL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

9031:MRGPRH
gene id: 9031:MRGPRH
uniprot id: A0A3Q3ALN6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:DNM1
gene id: 9031:DNM1
uniprot id: A0A8V1AHL8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9031:MAP3K13
gene id: 9031:MAP3K13
uniprot id: A0A1D5P0M9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9031:FSHR
gene id: 9031:FSHR
uniprot id: P79763
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB.

9031:CHST8
gene id: 9031:CHST8
uniprot id: F1NIQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:AATF
gene id: 9031:AATF
uniprot id: Q5ZIM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AATF family.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May function as a general inhibitor of the histone deacetylase HDAC1 (By similarity).
messages: nucleolus

9031:UNC5B
gene id: 9031:UNC5B
uniprot id: E1C228
uniprot id: Q5K6J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9031:ELOVL4
gene id: 9031:ELOVL4
uniprot id: E3VVZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9031:PEX5
gene id: 9031:PEX5
uniprot id: Q5ZMQ9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5.
messages: Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting translocation through the PEX13-PEX14 docking complex (By similarity). Interacts with PEX7, promoting peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal (By similarity).
messages: Monoubiquitinated at Cys-11 by PEX2 during PEX5 passage through the retrotranslocation channel (By similarity). Cys-11 monoubiquitination acts as a recognition signal for the PEX1-PEX6 complex and is required for PEX5 extraction and export from peroxisomes. When PEX5 recycling is compromised, polyubiquitinated by PEX10 during its passage through the retrotranslocation channel, leading to its degradation (By similarity).
messages: Peroxisome matrix
messages: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.
messages: The TPR repeats mediate interaction with proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type).
messages: The WxxxF/Y motifs mediate interaction with PEX14, promoting association with the PEX13-PEX14 docking complex.
messages: The amphipathic helix 1 and 2 (AH1 and AH2, respectively) are required for PEX5 retrotranslocation and recycling. AH2 mediates interaction with lumenal side of the PEX2-PEX10-PEX12 ligase complex, while AH1 is required for extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex.
messages: cytosol

9031:DIO1
gene id: 9031:DIO1
uniprot id: O42411
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iodothyronine deiodinase family.
messages: Endoplasmic reticulum membrane
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

9031:MOV10
gene id: 9031:MOV10
uniprot id: Q5ZKD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) (By similarity). Required for embryonic viability and for normal central nervous system development and function. May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity).
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: Cytoplasm
messages: Cytoplasmic ribonucleoprotein granule
messages: Nucleus
messages: P-body
messages: Stress granule

9031:LOC101750836
gene id: 9031:LOC101750836
uniprot id: A0A1D5P2V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:ERAL1
gene id: 9031:ERAL1
uniprot id: Q8JIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity).

9031:ZC3H14
gene id: 9031:ZC3H14
uniprot id: Q5F3Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: May bind to RNA.
messages: Nucleus speckle

9031:MYH1F
gene id: 9031:MYH1F
uniprot id: Q9PTY2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:KIF1BP
gene id: 9031:KIF1BP
uniprot id: Q5ZIL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
messages: cytoskeleton

9031:LGALS1B
gene id: 9031:LGALS1B
uniprot id: P23668
names: Function
names: Subunit
names: Tissue Specificity
messages: Homodimer.
messages: Mainly in the liver (adult), mainly in the muscle (embryo).
messages: This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation.

9031:NOC2L
gene id: 9031:NOC2L
uniprot id: Q5ZJT9
names: Similarity
messages: Belongs to the NOC2 family.

9031:TGM4
gene id: 9031:TGM4
uniprot id: Q5ZK99
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9031:SGCD
gene id: 9031:SGCD
uniprot id: E1C6L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9031:KIF2B
gene id: 9031:KIF2B
uniprot id: A0A3Q2UFD1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:SDHB
gene id: 9031:SDHB
uniprot id: A0A1D5PIF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9031:LYN
gene id: 9031:LYN
uniprot id: Q5ZMB9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9031:SNRPC
gene id: 9031:SNRPC
uniprot id: E1C6F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus

9031:UPRT
gene id: 9031:UPRT
uniprot id: Q5ZIJ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPRTase family.
messages: Cytoplasm
messages: Nucleus
messages: The uracil binding region known from UPRTases is missing.

9031:AP3S1
gene id: 9031:AP3S1
uniprot id: Q5ZJE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9031:PMEL
gene id: 9031:PMEL
uniprot id: Q98917
names: Developmental Stage
names: Function
names: PTM
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PMEL/NMB family.
messages: Expressed during the redifferentiation of pigmented epithelial cells (PEC).
messages: Glycosylated.
messages: Melanosome lumen
messages: Might be required for polymerization of melanin onto the core structure of melanosomes with enzymatic function of tyrosinase.
messages: Mutations in PMEL cause the Dominant white, Dun and Smoky plumage phenotypes in chicken. Both Dominant white and Dun inhibit the expression of black eumelanin giving rise to white plumage while Smoky gives a gray phenotype. The Dominant white phenotype is a breed characteristic of the White leghorn strain.
messages: Specific to pigmented epithelial cells and melanocytes. Not expressed in lens, neural retina, brain, heart, gizzard or liver.

9031:MCU
gene id: 9031:MCU
uniprot id: A0A1D5P9H3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9031:VPS45
gene id: 9031:VPS45
uniprot id: Q5ZJG4
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9031:SOX1
gene id: 9031:SOX1
uniprot id: O57401
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation.

9031:CDK2AP1
gene id: 9031:CDK2AP1
uniprot id: A0A1D5PQL4
uniprot id: Q5ZMM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9031:HSPA5
gene id: 9031:HSPA5
uniprot id: Q90593
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cell surface
messages: Cytoplasm
messages: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). May also play a role in apoptosis and cell proliferation (By similarity).
messages: Endoplasmic reticulum lumen
messages: Melanosome
messages: Monomer and homooligomer; homooligomerization via the interdomain linker inactivates the chaperone activity and acts as a storage of HSPA5/BiP molecules (By similarity). Interacts with DNAJC10 (By similarity). Interacts with DNAJB9/ERdj4; leading to recruit HSPA5/BiP to ERN1/IRE1. Interacts with ERN1/IRE1; interaction takes place following interaction with DNAJB9/ERdj4 and leads to inactivate ERN1/IRE1 (By similarity).
messages: The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains (By similarity). In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction (By similarity). In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates (By similarity). J domain-containing co-chaperones (DNAJB9/ERdj4 or DNAJC10/ERdj5) stimulate the ATPase activity and are required for efficient substrate recognition by HSPA5/BiP. Homooligomerization inactivates participating HSPA5/BiP protomers and probably act as reservoirs to store HSPA5/BiP molecules when they are not needed by the cell (By similarity).
messages: The interdomain linker regulates the chaperone activity by mediating the formation of homooligomers. Homooligomers are formed by engagement of the interdomain linker of one HSPA5/BiP molecule as a typical substrate of an adjacent HSPA5/BiP molecule. HSPA5/BiP oligomerization inactivates participating HSPA5/BiP protomers. HSPA5/BiP oligomers probably act as reservoirs to store HSPA5/BiP molecules when they are not needed by the cell. When the levels of unfolded proteins rise, cells can rapidly break up these oligomers to make active monomers.

9031:RHOT2
gene id: 9031:RHOT2
uniprot id: Q5ZM83
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.

9031:CHST13
gene id: 9031:CHST13
uniprot id: A0A1D5PTT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:PDK3
gene id: 9031:PDK3
uniprot id: Q5ZLT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9031:DCUN1D1
gene id: 9031:DCUN1D1
uniprot id: Q5ZKU1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates.

9031:TPRKB
gene id: 9031:TPRKB
uniprot id: E1BXT5
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9031:P2RX5
gene id: 9031:P2RX5
uniprot id: A0A8V1AF28
uniprot id: Q9IAD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9031:SEMA3A
gene id: 9031:SEMA3A
uniprot id: Q90607
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Expressed at relatively high levels in brain and muscle, moderate levels in lung, bursa, and heart and virtually absent in liver. Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.
messages: Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to neuropilin.
messages: Secreted
messages: Strong binding to neuropilin is mediated by the carboxy third of the protein.

9031:EDIL3
gene id: 9031:EDIL3
uniprot id: A0A3Q3ADW5
uniprot id: F1NCN3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SPTAN1
gene id: 9031:SPTAN1
uniprot id: P07751
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spectrin family.
messages: Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with ACP1 (By similarity).
messages: Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
messages: Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.
messages: cell cortex
messages: cytoskeleton

9031:SPATS2L
gene id: 9031:SPATS2L
uniprot id: Q5ZHU5
names: Similarity
messages: Belongs to the SPATS2 family.

9031:SLC11A2
gene id: 9031:SLC11A2
uniprot id: B3F8C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9031:RFC2
gene id: 9031:RFC2
uniprot id: P53033
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family.
messages: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA (By similarity).
messages: Nucleus
messages: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).

9031:AHCYL2
gene id: 9031:AHCYL2
uniprot id: A0A1D5PF77
uniprot id: A0A1L1S0T2
uniprot id: A0A8V0XM35
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9031:NDUFV1
gene id: 9031:NDUFV1
uniprot id: Q5ZHS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9031:MBNL1
gene id: 9031:MBNL1
uniprot id: Q5ZKW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the muscleblind family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA (By similarity).
messages: Nucleus

9031:TMEM184A
gene id: 9031:TMEM184A
uniprot id: A0A8V0Z4G7
names: Subcellular Location Annotation
messages: Membrane

9031:PIGV
gene id: 9031:PIGV
uniprot id: A0A1D5PLM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9031:SYBU
gene id: 9031:SYBU
uniprot id: A0A1D5NVV7
names: Subcellular Location Annotation
messages: Membrane

9031:CSF2RA
gene id: 9031:CSF2RA
uniprot id: F1NFE8
names: Subcellular Location Annotation
messages: Membrane

9031:VPS51
gene id: 9031:VPS51
uniprot id: Q5ZJ25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex Component of the endosome-associated retrograde protein (EARP) complex.
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Recycling endosome
messages: trans-Golgi network

9031:LIN28A
gene id: 9031:LIN28A
uniprot id: Q45KJ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-28 family.
messages: Cytoplasm
messages: Monomer.
messages: P-body
messages: RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Suppressor of microRNA (miRNA) biogenesis, including that of let-7. Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity).
messages: Rough endoplasmic reticulum
messages: Stress granule
messages: The CCHC zinc fingers interact with the GGAG motif at the 3' end of let-7 miRNAs precursors, more generally they bind the 5'-NGNNG-3' consensus motif with micromolar affinity. The CSD domain recognizes the loop at the 5' end. The flexible linker allows accommodating variable sequences and lengths among let-7 family members (By similarity).
messages: nucleolus

9031:JAK1
gene id: 9031:JAK1
uniprot id: F1NMJ9
uniprot id: Q9PWM9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9031:AMPH
gene id: 9031:AMPH
uniprot id: P50478
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Heterodimer with BIN1. Binds SH3GLB1 (By similarity).
messages: Is abundant in the forebrain and cerebellum. It is also found in the adrenal gland, anterior and posterior pituitary.
messages: May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
messages: cytoskeleton
messages: synaptic vesicle membrane

9031:RAB11FIP4
gene id: 9031:RAB11FIP4
uniprot id: A0A8V1AJ99
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

9031:NR2E3
gene id: 9031:NR2E3
uniprot id: Q90WV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:H3F3B
gene id: 9031:H3F3B
uniprot id: P84247
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me). Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with zmynd11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

9031:EXOC2
gene id: 9031:EXOC2
uniprot id: F1P2A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9031:ARRDC3
gene id: 9031:ARRDC3
uniprot id: A0A3Q2UEQ1
names: Similarity
messages: Belongs to the arrestin family.

9031:AvBD11
gene id: 9031:AvBD11
uniprot id: Q6IV20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Detected in outer membrane of the vitelline layer of the egg (at protein level). Expressed in the liver, gall bladder, kidney, testis, ovary and male and female reproductive tracts. Expressed in the ovarian stroma, but not in the ovarian follicles. No expression is detected in bone marrow.
messages: Has bactericidal activity.
messages: Secreted

9031:POLR2F
gene id: 9031:POLR2F
uniprot id: Q9PT88
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9031:AK2
gene id: 9031:AK2
uniprot id: A0A8V0Z310
uniprot id: F1NJ73
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9031:RPS16
gene id: 9031:RPS16
uniprot id: R4GGJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Nucleus

9031:PLCZ1
gene id: 9031:PLCZ1
uniprot id: Q2VRL0
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed specifically in testis.
messages: Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
messages: Nucleus
messages: The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.
messages: The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
messages: perinuclear region

9031:CD200R1A
gene id: 9031:CD200R1A
uniprot id: Q2YHT7
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CD200R family.
messages: Glycosylated.
messages: Highly expressed in macrophages, peripheral blood lymphocytes (PBL) and peripheral blood mononuclear cells (PBMC). Weakly expressed in bursa, thymus, spleen, liver and brain.
messages: Membrane
messages: Phosphorylated.
messages: Secreted

9031:ST7L
gene id: 9031:ST7L
uniprot id: Q90YH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9031:NARF
gene id: 9031:NARF
uniprot id: E1BYV6
names: Similarity
messages: Belongs to the NARF family.

9031:CNEP1R1
gene id: 9031:CNEP1R1
uniprot id: A0A1D5PB80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9031:ATG13
gene id: 9031:ATG13
uniprot id: A0A3Q2U2X5
uniprot id: A0A8V0ZR64
uniprot id: A0A8V0ZU38
uniprot id: A0A8V0ZU68
uniprot id: E1BQS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9031:TERF1
gene id: 9031:TERF1
uniprot id: Q5F3M6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus

9031:TMA16
gene id: 9031:TMA16
uniprot id: E1BVH6
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9031:MFN2
gene id: 9031:MFN2
uniprot id: A0A8V0Z1C3
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9031:RAP2B
gene id: 9031:RAP2B
uniprot id: A0A8V0XBX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

9031:ATAD2B
gene id: 9031:ATAD2B
uniprot id: A0A1D5PXZ4
uniprot id: A0A8V0XYN1
names: Similarity
messages: Belongs to the AAA ATPase family.

9031:HS3ST3A1
gene id: 9031:HS3ST3A1
uniprot id: F1NL56
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:EDF1
gene id: 9031:EDF1
uniprot id: Q5ZMC0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable transcriptional coactivator.

9031:LOC426957
gene id: 9031:LOC426957
uniprot id: A0A3Q3B2H5
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:PGR
gene id: 9031:PGR
uniprot id: P07812
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Nucleus
messages: Oviduct and bursa of Fabricius.
messages: Phosphorylation of Ser-529 is sharply increased upon progesterone treatment, whereas phosphorylation of Ser-210 and Ser-259 is modestly induced by progesterone.
messages: Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-385, the main site of sumoylation, is repressed by ubiquitination on the same site (By similarity).
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
messages: Ubiquitinated. Ubiquitination is increased by progesterone and represses sumoylation at the same site (By similarity).

9031:WNT7B
gene id: 9031:WNT7B
uniprot id: Q3L254
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Detected in the anterior parencephalon and secondary prosencephalon at stages 20 and 24. Expressed in the ventricular epithelium of the spinal cord at the latest stages.
messages: Expressed in differentiating lens fiber cells.
messages: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Produced by alternative splicing.
messages: Secreted
messages: extracellular matrix

9031:ME1
gene id: 9031:ME1
uniprot id: Q90XC0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9031:MTNR1B
gene id: 9031:MTNR1B
uniprot id: A0A0A0MQ60
uniprot id: P51050
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Brain and kidney, with trace levels in lungs.
messages: Cell membrane
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).
messages: Membrane

9031:MAP3K9
gene id: 9031:MAP3K9
uniprot id: A0A8V0ZBZ2
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9031:AvBD13
gene id: 9031:AvBD13
uniprot id: Q6IV18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Expressed in the liver, gall bladder, kidney, small intestine, spleen, testis, ovary and male and female reproductive tracts. Not detected in the ovarian stroma and the theca and granulosa layers of the ovarian follicle.
messages: Has bactericidal activity.
messages: Has bactericidal activity. Potent activity against E.coli, L.monocytogenes, S.typhimurium and S.pyogenes but mot against S.aureus.
messages: Secreted

9031:AOX2
gene id: 9031:AOX2
uniprot id: Q2QB49
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9031:LSM14A
gene id: 9031:LSM14A
uniprot id: A0A8V0Y533
uniprot id: A0A8V0Y9F2
uniprot id: Q5ZL27
names: Similarity
messages: Belongs to the LSM14 family.

9031:SGK3
gene id: 9031:SGK3
uniprot id: Q5ZJQ4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9031:GGT2
gene id: 9031:GGT2
uniprot id: F1NVY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9031:PI4K2B
gene id: 9031:PI4K2B
uniprot id: Q5ZIK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Cell membrane
messages: Contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: cytosol

9031:IFNAR1
gene id: 9031:IFNAR1
uniprot id: Q9YHW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9031:HTR2C
gene id: 9031:HTR2C
uniprot id: F1N989
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:IDS
gene id: 9031:IDS
uniprot id: A0A1L1RU31
names: Similarity
messages: Belongs to the sulfatase family.

9031:HAUS1
gene id: 9031:HAUS1
uniprot id: A0A8V0YG61
uniprot id: Q5ZJG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9031:GJB5
gene id: 9031:GJB5
uniprot id: A0A3Q2U3Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:NKD1
gene id: 9031:NKD1
uniprot id: A0A3Q2TWQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm

9031:CSRP1
gene id: 9031:CSRP1
uniprot id: P67966
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expression levels increase dramatically during smooth muscle maturation.
messages: Glycine-rich repeats mediate the association with the actin cytoskeleton.
messages: Heat stable protein, that interacts with zyxin/ZYX. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.
messages: Most prominent in tissues that are enriched in smooth muscle cells, such as gizzard, stomach, and intestine. Lower level in the heart, no expression in liver, skeletal muscle, or brain.
messages: Nucleus
messages: Probable monomer. Interacts with ZYX.
messages: cytoskeleton

9031:PAQR8
gene id: 9031:PAQR8
uniprot id: Q5ZHZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9031:CCNE2
gene id: 9031:CCNE2
uniprot id: A0A8V0YML2
uniprot id: Q5ZMH4
names: Similarity
messages: Belongs to the cyclin family.

9031:SGSM3
gene id: 9031:SGSM3
uniprot id: A0A8V0YBZ6
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

9031:AGO1
gene id: 9031:AGO1
uniprot id: A0A1D5PXD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9031:CENPL
gene id: 9031:CENPL
uniprot id: Q1T7C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-L/IML3 family.
messages: Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: Component of the CENPA-HI complex, at least composed of CENPH, CENPI, CENPK, CENPL, CENPM, CENPO and CENPP.
messages: Nucleus
messages: centromere

9031:GBE
gene id: 9031:GBE
uniprot id: Q5QRU6
names: Similarity
messages: Belongs to the globin family.

9031:SLC25A19
gene id: 9031:SLC25A19
uniprot id: A0A8V1ANF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:GJA8
gene id: 9031:GJA8
uniprot id: P36381
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels. Forms heteromeric channels with GJA3 (By similarity). During early stages of lens development, interacts with the C-terminus of MIP (PubMed:14762116).
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Phosphorylated on Ser-364; which inhibits cleavage by caspase-3.
messages: Proteolytically cleaved by caspase-3 during lens development.
messages: Structural component of eye lens gap junctions (PubMed:8049527). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:8049527).
messages: gap junction

9031:SOUL
gene id: 9031:SOUL
uniprot id: Q9W6E5
names: Similarity
messages: Belongs to the HEBP family.

9031:SCUBE1
gene id: 9031:SCUBE1
uniprot id: A0A8V0YDB7
uniprot id: A0A8V0YFI3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:DLD
gene id: 9031:DLD
uniprot id: Q5ZM32
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9031:ASF1A
gene id: 9031:ASF1A
uniprot id: Q3C1E9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. May also cooperate with HIRA to promote replication-independent chromatin assembly.
messages: Interacts with CHAF1B, HIRA, histone H3 and histone H4.
messages: Nucleus
messages: Phosphorylated.

9031:ADAM11
gene id: 9031:ADAM11
uniprot id: A0A8V0ZSU7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:MAP1LC3B
gene id: 9031:MAP1LC3B
uniprot id: Q5ZLF8
names: Similarity
messages: Belongs to the ATG8 family.

9031:TARBP2
gene id: 9031:TARBP2
uniprot id: A0A8V1A0R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC.

9031:ATP6V0A2
gene id: 9031:ATP6V0A2
uniprot id: A0A8V1A3F7
uniprot id: Q9I8C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9031:SQLE
gene id: 9031:SQLE
uniprot id: Q5ZKQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9031:PRKAB1
gene id: 9031:PRKAB1
uniprot id: Q27IP4
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9031:CPA6
gene id: 9031:CPA6
uniprot id: Q5ZIF7
names: Similarity
messages: Belongs to the peptidase M14 family.

9031:USP9Y
gene id: 9031:USP9Y
uniprot id: E1BWJ5
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:GNG5
gene id: 9031:GNG5
uniprot id: R4GKD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9031:AP3S2
gene id: 9031:AP3S2
uniprot id: E1BTE9
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9031:ING5
gene id: 9031:ING5
uniprot id: Q5ZHX3
uniprot id: Q5ZJ84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9031:KDELR2
gene id: 9031:KDELR2
uniprot id: Q5ZKX9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (PubMed:30846601). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (PubMed:30846601).

9031:FKTN
gene id: 9031:FKTN
uniprot id: A0A8V0YI97
names: Similarity
messages: Belongs to the LicD transferase family.

9031:CSTF3
gene id: 9031:CSTF3
uniprot id: Q5F4A0
names: Subcellular Location Annotation
messages: Nucleus

9031:TBX20
gene id: 9031:TBX20
uniprot id: Q8UW76
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator involved in heart developmental processes.
messages: Expression detected from stage 2 in the primitive streak. During subsequent stages of primitive streak formation (stages 2-4), expression seen in the extraembryonic mesoderm and lateral mesoderm, and weakly in the elongating primitive streak. Concomitant with the onset of node and streak regression (stage 5), the expression in the lateral mesoderm extends to the anterior limit of the mesodermal cell layer. After gastrulation, continuously expressed in the heart-forming region and also detected in other regions such as the allantois, optic vesicle, hindbrain and ventral neural tube.
messages: Nucleus

9031:ST3GAL2
gene id: 9031:ST3GAL2
uniprot id: Q5ZJJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:CCR7
gene id: 9031:CCR7
uniprot id: E3VW39
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:SLC4A2
gene id: 9031:SLC4A2
uniprot id: Q90710
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

9031:ITPR3
gene id: 9031:ITPR3
uniprot id: A0A8V1ACE6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9031:SCG5
gene id: 9031:SCG5
uniprot id: Q5ZI41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 7B2 family.
messages: Secreted

9031:KCNN2
gene id: 9031:KCNN2
uniprot id: Q9PTS9
names: Subcellular Location Annotation
messages: Membrane

9031:ZC3H15
gene id: 9031:ZC3H15
uniprot id: A0A1D5PMI7
uniprot id: Q5H7N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZC3H15/TMA46 family.
messages: Cytoplasm
messages: Interacts with DRG1.
messages: Nucleus
messages: Protects DRG1 from proteolytic degradation.

9031:CRHR1
gene id: 9031:CRHR1
uniprot id: Q90812
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
messages: Interacts (via N-terminal extracellular domain) with CRF and UCN.
messages: The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).

9031:ATP6V0A1
gene id: 9031:ATP6V0A1
uniprot id: A0A1D5P5R9
uniprot id: Q9I8D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Detected in brain (at protein level). Highest expression in brain, intermediate levels in kidney, and relatively low levels in bone and liver.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Melanosome
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits (By similarity).
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9031:UPF3B
gene id: 9031:UPF3B
uniprot id: Q5ZHV0
names: Similarity
messages: Belongs to the RENT3 family.

9031:VPS29
gene id: 9031:VPS29
uniprot id: Q5ZIL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrins. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (By similarity).
messages: Belongs to the VPS29 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants (By similarity). Component of the heterotrimeric retriever complex (By similarity).
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9031:PGP
gene id: 9031:PGP
uniprot id: Q5F4B1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP.
messages: Homodimer.

9031:MAP2K6
gene id: 9031:MAP2K6
uniprot id: A0A1D5PHN6
uniprot id: F1NVF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:LOC771422
gene id: 9031:LOC771422
uniprot id: A0A8V0ZCR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9031:CD38
gene id: 9031:CD38
uniprot id: E5G6H6
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9031:SMARCA1
gene id: 9031:SMARCA1
uniprot id: A0A8V0YU45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9031:CSRNP3
gene id: 9031:CSRNP3
uniprot id: A0A8V1A5V4
uniprot id: A0A8V1A5V9
uniprot id: F1NPN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9031:NHLRC2
gene id: 9031:NHLRC2
uniprot id: Q5ZI67
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Monomer.
messages: Required for normal embryonic development.
messages: cytosol

9031:COPE
gene id: 9031:COPE
uniprot id: Q5ZIK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

9031:TTC3
gene id: 9031:TTC3
uniprot id: A0A8V0YQG6
uniprot id: F1P0T0
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ABAT
gene id: 9031:ABAT
uniprot id: E1C8M8
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9031:ESR2
gene id: 9031:ESR2
uniprot id: Q9PTU5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ER-alpha.
messages: Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Nucleus

9031:MTO1
gene id: 9031:MTO1
uniprot id: A0A1D5PM29
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

9031:LOC428824
gene id: 9031:LOC428824
uniprot id: A0A8V0ZJM3
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9031:VRTN
gene id: 9031:VRTN
uniprot id: A0A1D5PDU0
names: Similarity
messages: Belongs to the vertnin family.

9031:FGF13
gene id: 9031:FGF13
uniprot id: F1NWP9
uniprot id: Q9IAI3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:AARS2
gene id: 9031:AARS2
uniprot id: Q5ZIA1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9031:VPS37D
gene id: 9031:VPS37D
uniprot id: A0A8V1AIQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9031:TUBB1
gene id: 9031:TUBB1
uniprot id: P09207
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Highly expressed in bone marrow.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:PTGES3
gene id: 9031:PTGES3
uniprot id: A0A8V1A993
uniprot id: Q90955
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Binds to telomerase (By similarity). Binds to the progesterone receptor (PubMed:8114727).
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.
messages: Molecular chaperone.

9031:ART1L1
gene id: 9031:ART1L1
uniprot id: Q49L21
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9031:SS18L1
gene id: 9031:SS18L1
uniprot id: F1NW13
names: Similarity
messages: Belongs to the SS18 family.

9031:PDHB
gene id: 9031:PDHB
uniprot id: A0A1D5P1U2
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9031:DBR1
gene id: 9031:DBR1
uniprot id: Q5ZLM2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Active in presence of diverse metals including Fe(2+), Zn(2+), Mn(2+) (By similarity). Also activated by Ca(2+) (By similarity). Binds two metal cations in two adjacent alpha and beta metal-binding pockets (By similarity).
messages: Belongs to the lariat debranching enzyme family.
messages: Binds 2 divalent metal cations per subunit.
messages: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function.
messages: Nucleus

9031:SAXO2
gene id: 9031:SAXO2
uniprot id: F1NE52
names: Similarity
messages: Belongs to the FAM154 family.

9031:KDELC1
gene id: 9031:KDELC1
uniprot id: E1BSM9
names: Similarity
messages: Belongs to the KDELC family.

9031:LHFPL3
gene id: 9031:LHFPL3
uniprot id: A0A8V0Y3U4
uniprot id: A0A8V0YCG5
names: Subcellular Location Annotation
messages: Membrane

9031:RIPK2
gene id: 9031:RIPK2
uniprot id: Q5ZJT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments.

9031:ZDHHC13
gene id: 9031:ZDHHC13
uniprot id: A0A8V0ZH00
uniprot id: Q5ZHL4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:UGDH
gene id: 9031:UGDH
uniprot id: Q5F3T9
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity).
messages: Homohexamer.
messages: The allosteric switch region moves by about 5 Angstroms when UDP-xylose is bound, and occupies part of the UDP-glucose binding site. At the same time it promotes domain movements that disrupt the active hexameric ring structure and lead to the formation of a horseshoe-shaped, inactive hexamer.
messages: The protein goes through several conformation states during the reaction cycle, giving rise to hysteresis. In the initial state, the ligand-free protein is in an inactive conformation (E*). Substrate binding triggers a change to the active conformation (E). UDP-xylose binding triggers the transition to a distinct, inhibited conformation. The presence of an intrinsically disordered C-terminus promotes a more dynamic protein structure and favors a conformation with high affinity for UPD-xylose.
messages: UDP-alpha-D-xylose (UDX) acts as a feedback inhibitor. It binds at the same site as the substrate, but functions as allosteric inhibitor by triggering a conformation change that disrupts the active hexameric ring structure and gives rise to an inactive, horseshoe-shaped hexamer.

9031:KCNJ4
gene id: 9031:KCNJ4
uniprot id: F1NI76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9031:PPIF
gene id: 9031:PPIF
uniprot id: Q5ZMJ0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9031:SULT6B1L
gene id: 9031:SULT6B1L
uniprot id: A0A1L1RLU1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:GLB1
gene id: 9031:GLB1
uniprot id: Q5ZLM4
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9031:CRISP2
gene id: 9031:CRISP2
uniprot id: A0A1D5PMF4
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:IDH3A
gene id: 9031:IDH3A
uniprot id: Q5ZI29
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9031:BCL2
gene id: 9031:BCL2
uniprot id: Q00709
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Also interacts with APAF1 and RAF-1 (By similarity).
messages: In adult chicken expressed, in thymus, spleen, kidney, heart, ovary and brain, with the highest levels in the thymus. In the embryo, highly levels expressed in all tissues with high levels in the bursa of Fabricius.
messages: Mitochondrion outer membrane
messages: Nucleus membrane
messages: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
messages: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1.

9031:CXorf36
gene id: 9031:CXorf36
uniprot id: F1NKD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9031:CRMP1
gene id: 9031:CRMP1
uniprot id: Q71SG3
uniprot id: Q71SG4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9031:ZHX3
gene id: 9031:ZHX3
uniprot id: A0A1D5NUM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9031:PSMD2
gene id: 9031:PSMD2
uniprot id: Q5ZLU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9031:HOMER2
gene id: 9031:HOMER2
uniprot id: A0A8V0YQ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9031:SLC17A6
gene id: 9031:SLC17A6
uniprot id: E1C256
names: Subcellular Location Annotation
messages: Membrane

9031:HN1
gene id: 9031:HN1
uniprot id: Q5ZMA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9031:TMEM138
gene id: 9031:TMEM138
uniprot id: A0A1D5PE71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9031:TOM1
gene id: 9031:TOM1
uniprot id: A0A3Q2UMT0
uniprot id: O12940
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (By similarity). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (By similarity). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (By similarity). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (By similarity). Binds to polyubiquitinated proteins via its GAT domain (By similarity). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (By similarity). Mediates clathrin recruitment to early endosomes (By similarity). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (By similarity). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (By similarity). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (By similarity). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (By similarity).
messages: Belongs to the TOM1 family.
messages: Cytoplasm
messages: Early endosome membrane
messages: Endosome membrane
messages: Expression is cooperatively activated by MYB and CEBPG.
messages: Found in a complex with TOLLIP; interacts (via GAT domain) with TOLLIP (via N-terminus); the interactions leads to TOM1-recruitment to endosomes and inhibition of TOLLIP binding to PtdIns(3)P (By similarity). Interacts (via GAT domain and the C-terminal part of the VHS domain) with UBC/ubiquitin (By similarity). Interacts (via clathrin box and C-terminus) with clathrin heavy chain (By similarity). Interacts with MYO6 (By similarity).
messages: Monoubiquitinated.
messages: The GAT domain and the VHS domain are required for the interaction with polyubiquitinated proteins.
messages: The VHS domain binds to phosphatidylinositol monophosphates (By similarity). The KRKK motif within the VHS domain is required for binding to phosphatidylinositol monophosphates, with a preference for phosphatidylinositol 5-phosphate (PtdIns(5)P) (By similarity).

9031:FUBP1
gene id: 9031:FUBP1
uniprot id: A0A8V0ZMG8
uniprot id: Q5ZHW0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:API5
gene id: 9031:API5
uniprot id: Q5ZMW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiapoptotic factor that may have a role in protein assembly.
messages: Belongs to the API5 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9031:EFTUD2
gene id: 9031:EFTUD2
uniprot id: Q5F3X4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). Component of the pre-catalytic, catalytic and post-catalytic spliceosome complexes (By similarity). Component of the minor spliceosome, which splices U12-type introns (By similarity).
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).

9031:LPCAT2
gene id: 9031:LPCAT2
uniprot id: Q5ZIX5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9031:MRPL3
gene id: 9031:MRPL3
uniprot id: Q5ZLP6
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9031:MYH9
gene id: 9031:MYH9
uniprot id: P14105
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
messages: Cortical granule
messages: Expressed in fibroblasts, brain, lung, kidney, spleen, and skeletal, cardiac and smooth muscles.
messages: Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: cell cortex
messages: cytoskeleton

9031:ATL2
gene id: 9031:ATL2
uniprot id: A0A8V0Z690
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9031:C21orf59
gene id: 9031:C21orf59
uniprot id: Q5ZIK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9031:INHBA
gene id: 9031:INHBA
uniprot id: P27092
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Ciliary ganglion neurons. Levels are higher in the choroid than the iris.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Induces somatostatin in the ciliary ganglion neurons and may play a role in regulating neurotransmitter phenotype.
messages: Levels increase in the iris from embryonic day 9 (9 dpc) to 16 dpc and in the choroid, levels are high from 9 dpc to 14 dpc but drop at 16 dpc.
messages: Secreted

9031:EVC2
gene id: 9031:EVC2
uniprot id: Q5QGM3
names: Subcellular Location Annotation
messages: Membrane
messages: cilium basal body
messages: cilium membrane

9031:PIGC
gene id: 9031:PIGC
uniprot id: A0A1D5P2C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9031:PPIA
gene id: 9031:PPIA
uniprot id: D0EKR3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9031:NKX2-5
gene id: 9031:NKX2-5
uniprot id: Q90788
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NK-2 homeobox family.
messages: Homodimer (via the homeobox); binds DNA as homodimer.
messages: Nucleus
messages: The homeobox domain binds to double-stranded DNA.
messages: Transcription factor required for the development of the heart and the spleen. Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter.

9031:SMAP2
gene id: 9031:SMAP2
uniprot id: Q5F413
names: Function
names: Subunit
messages: GTPase activating protein. May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).
messages: May interact with clathrin heavy chains.

9031:TRAIL-LIKE
gene id: 9031:TRAIL-LIKE
uniprot id: Q90WT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

9031:LIMK2
gene id: 9031:LIMK2
uniprot id: P53666
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Binds ROCK1 and LKAP.
messages: Expressed predominantly in the lung, and faintly in the kidney, liver, brain, spleen, gizzard, and intestine.
messages: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP.
messages: centrosome
messages: spindle

9031:SEC24C
gene id: 9031:SEC24C
uniprot id: A0A3Q2UGR5
uniprot id: E1BUD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9031:GSTCD
gene id: 9031:GSTCD
uniprot id: F1NKT3
names: Similarity
messages: Belongs to the GSTCD family.

9031:PMS1
gene id: 9031:PMS1
uniprot id: Q5ZKT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9031:HSPD1
gene id: 9031:HSPD1
uniprot id: Q5ZL72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chaperonin (HSP60) family.
messages: Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.
messages: Mitochondrion matrix

9031:ARHGAP15
gene id: 9031:ARHGAP15
uniprot id: Q5ZMM3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
messages: Membrane

9031:ADCY8
gene id: 9031:ADCY8
uniprot id: A0A1D5PGV0
uniprot id: A0A1D5PNE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9031:CDK1
gene id: 9031:CDK1
uniprot id: F1NBD7
uniprot id: P13863
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Phosphorylated at Tyr-15 by Rous sarcoma virus v-oncogene Src, possibly causing mitotic slippage.
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase.
messages: Nucleus
messages: Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts negative regulator of entry into mitosis (G2 to M transition).
messages: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins. May play a role in regulating the amplitude of the cyclic expression of circadian clock genes.
messages: Thr-14 and Tyr-15 are phosphorylated maximally during G2 phase, but dephosphorylated abruptly at the G2/M transition. Phosphorylation at Thr-14 and Tyr-15 inactivates the enzyme. During M phase it is also phosphorylated on Thr-161. Finally during G1 phase it is phosphorylated on Ser-277.
messages: centrosome

9031:CA13
gene id: 9031:CA13
uniprot id: A0A1D5NX31
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9031:SLC4A9
gene id: 9031:SLC4A9
uniprot id: A0A8V0Y7D1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9031:EIF4E3
gene id: 9031:EIF4E3
uniprot id: F7BFT4
uniprot id: Q5F3V7
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9031:CPB1
gene id: 9031:CPB1
uniprot id: E1BW20
names: Similarity
messages: Belongs to the peptidase M14 family.

9031:SNX2
gene id: 9031:SNX2
uniprot id: Q5F406
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9031:PHB
gene id: 9031:PHB
uniprot id: D5M8S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9031:SLC2A1
gene id: 9031:SLC2A1
uniprot id: P46896
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (PubMed:25957687). Required for mesendoderm differentiation (By similarity).
messages: Interacts with isoform 1 of BSG.
messages: Photoreceptor inner segment
messages: Retinal cones (at protein level).

9031:ACO2
gene id: 9031:ACO2
uniprot id: Q5ZMW1
uniprot id: Q8AYI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

9031:NAA35
gene id: 9031:NAA35
uniprot id: F1NYK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9031:SHISA5
gene id: 9031:SHISA5
uniprot id: Q5ZIS9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shisa family.
messages: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: The proline-rich region is required for endoplasmic reticulum localization.

9031:PSMD13
gene id: 9031:PSMD13
uniprot id: P84169
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9031:STAG2
gene id: 9031:STAG2
uniprot id: A0A1D5PY29
uniprot id: A0A8V0YD55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9031:HNF1B
gene id: 9031:HNF1B
uniprot id: A0A8V1AAZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9031:GSC
gene id: 9031:GSC
uniprot id: P53545
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Involved in the development of the organizer region in the gastrula (Hensen node in chicken).
messages: Is first expressed in the Koller's sickle (a crescent shaped thickening located at the edge of the posterior marginal zone), and then it is detected in Hensen node which is considered as the chick organizer. Later expression is seen in the anterior most region of the head process (cells that contribute to the prechordal plate at the midline of the pharyngeal mesendoderm).
messages: Nucleus

9031:VPS53
gene id: 9031:VPS53
uniprot id: Q5ZLD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Belongs to the VPS53 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome membrane
messages: Recycling endosome
messages: trans-Golgi network membrane

9031:NGLY1
gene id: 9031:NGLY1
uniprot id: Q5ZJM3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity).

9031:MTMR2
gene id: 9031:MTMR2
uniprot id: Q5ZIV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Early endosome membrane
messages: Homooligomer and heterooligomer.
messages: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).

9031:RB1
gene id: 9031:RB1
uniprot id: Q90600
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with, and is inhibited by fowl adenovirus 1 protein GAM-1.
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Interacts with and sequesters the E2F1 transcription factor. Interacts with SUV39H1, KMT5B and KMT5C (By similarity).
messages: Nucleus
messages: Phosphorylated in G1, thereby releasing E2F1 which is then able to activate cell growth. Dephosphorylated at the late M phase. Phosphorylation of domain C promotes interaction between the C-terminal domain C and the Pocket domain, and thereby inhibits interactions with heterodimeric E2F/DP transcription factor complexes (By similarity).
messages: Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C.

9031:ATOH7
gene id: 9031:ATOH7
uniprot id: O57598
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expressed in the developing retina, and in a tiny population of ventricular cells located in the ventral domain of the spinal cord and hindbrain. Retinal expression peaks at stage 29 (6 dpc).
messages: Nucleus
messages: Perikaryon
messages: The basic motif confers specificity for the CHRNB3 promoter.
messages: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity). Positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract (PubMed:11124117, PubMed:15342472, PubMed:16260616). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity). During retinal neurogenesis, activates its own transcription, as well as the transcription of CHRNB3 and BRN3 (PubMed:11172005).
messages: Up-regulated by NGN2 and ATOH7. Down-regulated by HES1.
messages: axon

9031:ARPC5
gene id: 9031:ARPC5
uniprot id: Q5ZMV5
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9031:SMU1
gene id: 9031:SMU1
uniprot id: Q5ZME8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SMU1 family.
messages: Component of the spliceosome B complex. Interacts with IK.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The WD repeats assemble into a seven-bladed WD propeller.

9031:KRT14
gene id: 9031:KRT14
uniprot id: Q6PVZ1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Expressed in epidermis.
messages: Heterotetramer of two type I and two type II keratins.
messages: Nucleus
messages: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

9031:HNRNPAB
gene id: 9031:HNRNPAB
uniprot id: A0A8V0YRG0
uniprot id: Q90602
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:ENTPD4
gene id: 9031:ENTPD4
uniprot id: A0A8V0ZAB3
uniprot id: E1C3V3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9031:XYLT2
gene id: 9031:XYLT2
uniprot id: Q6IVU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

9031:MRPL37
gene id: 9031:MRPL37
uniprot id: A0A8V0ZXG4
uniprot id: Q5ZI69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL37 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

9031:ICMT
gene id: 9031:ICMT
uniprot id: Q5ZMU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:COL17A1
gene id: 9031:COL17A1
uniprot id: Q90584
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cornea specific.
messages: Homotrimers of alpha 1(XVII)chains.
messages: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.
messages: Membrane
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The 120 kDa linear IgA disease antigen homolog is an anchoring filament component involved in dermal-epidermal cohesion.
messages: The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen homolog. The shedding is mediated by membrane-bound metalloproteases (By similarity).
messages: The intracellular/endo domain is disulfide-linked.
messages: basement membrane
messages: hemidesmosome

9031:DIAPH3
gene id: 9031:DIAPH3
uniprot id: A0A8V0XCP9
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

9031:NXPH1
gene id: 9031:NXPH1
uniprot id: F1NQI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9031:RSFR
gene id: 9031:RSFR
uniprot id: P30374
uniprot id: Q27J90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9031:ALKBH1
gene id: 9031:ALKBH1
uniprot id: Q5F3E4
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

9031:FUT10
gene id: 9031:FUT10
uniprot id: E1C2U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Probable fucosyltransferase.

9031:ST7
gene id: 9031:ST7
uniprot id: A0M8U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9031:CDS2
gene id: 9031:CDS2
uniprot id: A0A5P9VLA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9031:CCL17
gene id: 9031:CCL17
uniprot id: A0A8V0ZM98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:RRM1
gene id: 9031:RRM1
uniprot id: Q5ZM69
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9031:CKMT1B
gene id: 9031:CKMT1B
uniprot id: F1NXR0
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9031:WNT4
gene id: 9031:WNT4
uniprot id: P49337
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Interacts with CPZ.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Predominantly expressed in the diencephalon neuromere D2.
messages: extracellular matrix

9031:PSMA5
gene id: 9031:PSMA5
uniprot id: Q5ZJX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9031:FASLG
gene id: 9031:FASLG
uniprot id: Q5CAQ0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9031:PSMA7
gene id: 9031:PSMA7
uniprot id: O13268
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Interacts with HIF1A. Interacts with RAB7A. Interacts with PRKN. Interacts with ABL1 and ABL2. Interacts with EMAP2. Interacts with MAVS.

9031:CYP3A5
gene id: 9031:CYP3A5
uniprot id: Q9PU44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:GADD45A
gene id: 9031:GADD45A
uniprot id: Q2HZD6
names: Similarity
messages: Belongs to the GADD45 family.

9031:LIN28B
gene id: 9031:LIN28B
uniprot id: A0A8V0YK01
uniprot id: Q45KJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: Suppressor of specific microRNA (miRNA) biogenesis. Binds target primary miRNA transcripts and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. The specific interaction with target pri-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop.
messages: nucleolus

9031:PSMF1
gene id: 9031:PSMF1
uniprot id: Q5ZJL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

9031:HSD11B1L
gene id: 9031:HSD11B1L
uniprot id: Q6PUF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Secreted

9031:NAE1
gene id: 9031:NAE1
uniprot id: Q5ZIE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M (By similarity).
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity). The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development.

9031:ENO4
gene id: 9031:ENO4
uniprot id: A0A3Q3AEZ3
uniprot id: A0A8V0ZRT9
uniprot id: F1P5H2
names: Similarity
messages: Belongs to the enolase family.

9031:NDUFA11
gene id: 9031:NDUFA11
uniprot id: A0A8V1AFI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Mitochondrion inner membrane

9031:BBOX1
gene id: 9031:BBOX1
uniprot id: E1BXI0
names: Function
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

9031:TENM2
gene id: 9031:TENM2
uniprot id: Q9DER5
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediate axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer.
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.
messages: Derives from the membrane form by proteolytic processing.
messages: Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway.
messages: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
messages: Endoplasmic reticulum
messages: Expressed in external plexiform layer and laminae 1 and 3 within the inner plexiform layer (at protein level). Expression started to be detectable in 4-day-old embryos, both in the body as well as the head (brain) of the embryos. Expressed in neurons of the inner plexiform layer (IPL), the optic fiber layer (OFL) and the optic nerve at 11 dpc. Expressed in the neurons of the entire retinal ganglion cell layer at 12 dpc. Expressed by the neurons of the thalamofugal visual pathway at 18 dpc. Expressed in the developing limb buds, somites, and craniofacial mesenchyme at 19 dpc. In the limbs, expressed transiently in the apical ectodermal ridge (AER) and later at sites of tendon morphogenesis. Also found in the notochord, dorsal neural tube, and dorsomedial lip of the somite as well as the flank mesoderm.
messages: Golgi apparatus
messages: Homodimer; disulfide-linked (Probable). Heterodimer with other teneurins (By similarity).
messages: Induces gene transcription inhibition.
messages: PML body
messages: Postsynaptic cell membrane
messages: Synapse
messages: dendrite
messages: dendritic spine
messages: filopodium
messages: growth cone
messages: synaptosome

9031:PPP3R1
gene id: 9031:PPP3R1
uniprot id: Q6VN51
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9031:COG1
gene id: 9031:COG1
uniprot id: Q5ZI62
names: Similarity
messages: Belongs to the COG1 family.

9031:SLC25A28
gene id: 9031:SLC25A28
uniprot id: A0A8V0ZV06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:ACTBL2
gene id: 9031:ACTBL2
uniprot id: A0A1D5NV17
names: Similarity
messages: Belongs to the actin family.

9031:LEPROTL1
gene id: 9031:LEPROTL1
uniprot id: A0A140T8I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9031:TBX6
gene id: 9031:TBX6
uniprot id: Q564K6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:UBE2V1
gene id: 9031:UBE2V1
uniprot id: Q90879
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity). Together with RNF135 and UBE2N, may catalyze the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity).
messages: Nucleus

9031:ATPAF1
gene id: 9031:ATPAF1
uniprot id: A0A8V0ZT65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

9031:WNT11B
gene id: 9031:WNT11B
uniprot id: B2ZUA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:PIP4K2A
gene id: 9031:PIP4K2A
uniprot id: Q5F356
names: Activity Regulation
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: In rod outer segments, activated by light.
messages: Lysosome
messages: Nucleus
messages: Phosphorylated in tyrosines. Phosphorylation is induced by light and increases kinase activity.

9031:TMEM175
gene id: 9031:TMEM175
uniprot id: Q5ZKY0
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Active at low pH (under pH 4.6): proton channel activity is activated by luminal side protons. Polyunsaturated fatty acids, such as arachidonic acid, also activate the channel activity.
messages: Belongs to the TMEM175 family.
messages: Composed of two modules of six transmembranes, forming a homodimer with a tetrameric architecture. The six transmembrane regions of each module are tightly packed within each subunit without undergoing domain swapping. Forms a central ion-conduction pore lined by the side chains of the pore-lining helices. Conserved isoleucine residues (Ile-44 in the first module and Ile-271 in the second module) in the center of the pore serve as the gate in the closed conformation. In the widened channel in the open conformation, the same residues establish a constriction essential for potassium selectivity.
messages: Endosome membrane
messages: Homodimer.
messages: Lysosome membrane
messages: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH. Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis. Regulation of lumenal pH stability is required for autophagosome-lysosome fusion. May also act as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes. The potassium channel activity is however unclear as it was tested in non-physiological conditions for a lysosomal channel.

9031:LPAR1
gene id: 9031:LPAR1
uniprot id: B0FMV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9031:LOC100858504
gene id: 9031:LOC100858504
uniprot id: H9L3N3
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:PRMT7
gene id: 9031:PRMT7
uniprot id: Q5ZIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

9031:AvBD3
gene id: 9031:AvBD3
uniprot id: Q9DG58
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Expression in cultured vaginal cells is increased by LPS and S.enteritidis.
messages: Has bactericidal activity.
messages: In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens.
messages: Secreted
messages: Strongly expressed in the tongue, bone marrow, bursa of Fabricius and trachea. Also expressed in skin, esophagus and air sacs. Weak expression in the large intestine, kidney and ovary. Expressed in the vagina and ovarian stroma, but not in the ovarian follicle.

9031:NUSAP1
gene id: 9031:NUSAP1
uniprot id: Q5ZJU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NUSAP family.
messages: Cytoplasm
messages: Interacts with DNA and microtubules.
messages: Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity).
messages: Nucleus
messages: spindle

9031:TRAPPC5
gene id: 9031:TRAPPC5
uniprot id: Q5F359
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: cis-Golgi network

9031:NPY6R
gene id: 9031:NPY6R
uniprot id: Q2I810
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:SPIC
gene id: 9031:SPIC
uniprot id: A0A8V0YCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:RPS20
gene id: 9031:RPS20
uniprot id: F1NH93
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9031:AvBD7
gene id: 9031:AvBD7
uniprot id: Q6QLR2
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Detected in the theca and granulosa layers of the ovarian follicle in the white follicle (WF), F1, F3, F5, and postovulatory follicle stages.
messages: Has bactericidal activity.
messages: Induced in the theca layer of the F3 stage ovarian follicle by intravenous injection of LPS. Expression in the kidney and liver is not affected by intravenous injection of LPS.
messages: Secreted
messages: Strong expression in the bone marrow and testis. Expressed in the ovarian stroma and the theca layer of the ovarian follicles. Not expressed in the granulosa layer of the ovarian follicles.

9031:PAH
gene id: 9031:PAH
uniprot id: Q6PKI8
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9031:PRKACB
gene id: 9031:PRKACB
uniprot id: A0A1D5PLV3
uniprot id: A0A8V0ZH93
uniprot id: A0A8V0ZHB4
uniprot id: A0A8V0ZHB9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9031:TNFSF11
gene id: 9031:TNFSF11
uniprot id: A3RF19
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9031:MTX3
gene id: 9031:MTX3
uniprot id: Q5F3K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9031:SH3BGRL
gene id: 9031:SH3BGRL
uniprot id: Q5F3C9
names: Similarity
messages: Belongs to the SH3BGR family.

9031:LPL
gene id: 9031:LPL
uniprot id: P11602
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Ca(2+) binding promotes protein stability and formation of the active homodimer.
messages: Cell membrane
messages: Homodimer. Interacts with GPIHBP1 with 1:1 stoichiometry (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interaction with heparan sulfate proteoglycans is required to protect LPL against loss of activity. Associates with lipoprotein particles in blood plasma. Interacts with LMF1 and SEL1L; interaction with SEL1L is required to prevent aggregation of newly synthesized LPL in the endoplasmic reticulum (ER), and for normal export of LPL from the ER to the extracellular space (By similarity).
messages: Key enzyme in triglyceride metabolism (By similarity). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (By similarity). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity).
messages: N-glycan at Asn-70 is a triantennary complex oligosaccharide containing sialic acid, galactose, mannose, and N-acetylglucosamine, the reducing GlcNAc being sulfated at C6.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9031:NKX2-3
gene id: 9031:NKX2-3
uniprot id: O73907
names: Subcellular Location Annotation
messages: Nucleus

9031:ZMPSTE24
gene id: 9031:ZMPSTE24
uniprot id: A0A1L1RJ89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9031:NRN1
gene id: 9031:NRN1
uniprot id: A0A1D5PYZ2
names: Similarity
messages: Belongs to the neuritin family.

9031:WDR61
gene id: 9031:WDR61
uniprot id: Q5ZJH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKI8 family.
messages: Component of the PAF1 complex (By similarity). Component of the SKI complex (By similarity).
messages: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation.
messages: Cytoplasm
messages: Nucleus

9031:PDE9A
gene id: 9031:PDE9A
uniprot id: E1BZ04
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:NR2C2
gene id: 9031:NR2C2
uniprot id: A0A3Q2U2X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:PGGHG
gene id: 9031:PGGHG
uniprot id: F1NZI4
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.
messages: Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.

9031:RFTN1
gene id: 9031:RFTN1
uniprot id: Q7SZI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.

9031:BCL2L10
gene id: 9031:BCL2L10
uniprot id: Q90ZN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Bcl-2 family.
messages: Cell membrane
messages: Expressed preferentially in heart, skeletal muscle, retina, optical tectum and bursa of Fabricius.
messages: Interacts with BAX.
messages: Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX.

9031:DYRK3
gene id: 9031:DYRK3
uniprot id: A0A8V1A2C8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9031:FAHD1
gene id: 9031:FAHD1
uniprot id: F1NXZ7
names: Similarity
messages: Belongs to the FAH family.

9031:CDCA2
gene id: 9031:CDCA2
uniprot id: A0A3Q3AKP0
names: Subcellular Location Annotation
messages: Nucleus

9031:OSBPL8
gene id: 9031:OSBPL8
uniprot id: A0A3Q3AQG0
uniprot id: A0A8V0YK05
names: Similarity
messages: Belongs to the OSBP family.

9031:MBP
gene id: 9031:MBP
uniprot id: P15720
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin basic protein family.
messages: Homodimer.
messages: In the optic lobe, first detected at embryonic day 14. Expression strongly increases between embryonic days 16 and 18, reaches a maximum at postnatal day 1, and then declines again to the adult level.
messages: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
messages: Major isoform.
messages: Myelin membrane
messages: Several charge isomers are produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. Chicken MBP contains 4 charge components denoted as C1, C2, C3 and C8. C1 lacks any phosphorylation sites, whereas C2 and C3 contain respectively 10 and 8 phosphorylation sites and arginine residues modified to citrulline. All three charge components contain deamidated glutamines and asparagine, and a methylated arginine.

9031:LOC428525
gene id: 9031:LOC428525
uniprot id: E1C7I3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:STEEP1
gene id: 9031:STEEP1
uniprot id: E1BYZ0
names: Similarity
messages: Belongs to the STEEP1 family.

9031:WNT2
gene id: 9031:WNT2
uniprot id: A0A1D5NTF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:SERPIND1
gene id: 9031:SERPIND1
uniprot id: A0A1D5PLZ2
names: Similarity
messages: Belongs to the serpin family.

9031:WNT3
gene id: 9031:WNT3
uniprot id: A1DYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:CCDC103
gene id: 9031:CCDC103
uniprot id: A0A8V0ZL78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

9031:RAB33B
gene id: 9031:RAB33B
uniprot id: Q5ZHV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Golgi apparatus membrane
messages: Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation (By similarity).
messages: cis-Golgi network

9031:IL8L1
gene id: 9031:IL8L1
uniprot id: O73912
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

9031:DOK1
gene id: 9031:DOK1
uniprot id: A0A1D5PZ39
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9031:ZNF488
gene id: 9031:ZNF488
uniprot id: F1P059
names: Subcellular Location Annotation
messages: Nucleus

9031:UGT8L
gene id: 9031:UGT8L
uniprot id: F1NQS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9031:TGFB2
gene id: 9031:TGFB2
uniprot id: F1NNP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9031:GLRB
gene id: 9031:GLRB
uniprot id: F1P037
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9031:RHCG
gene id: 9031:RHCG
uniprot id: Q6XL41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Functions as an ammonia transporter.
messages: Homotrimer.

9031:GABRB2
gene id: 9031:GABRB2
uniprot id: F6SVX7
uniprot id: Q90590
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:TMEM38A
gene id: 9031:TMEM38A
uniprot id: Q5ZK43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM38 family.
messages: Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
messages: Nucleus membrane
messages: Sarcoplasmic reticulum membrane

9031:HMGCLL1
gene id: 9031:HMGCLL1
uniprot id: A0A8V0X2E0
uniprot id: E1BU09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9031:NR6A1
gene id: 9031:NR6A1
uniprot id: A0A8V1AG53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:SLC19A1
gene id: 9031:SLC19A1
uniprot id: Q5ZMS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: Transporter that mediates the import of reduced folates.

9031:GUCA1A
gene id: 9031:GUCA1A
uniprot id: P79880
names: Domain
names: Function
names: Tissue Specificity
messages: Binds three calcium ions (via EF-hands 2, 3 and 4) when calcium levels are high (PubMed:17997965). Binds Mg(2+) when calcium levels are low.
messages: Retina, in rod and cone outer segments, and pineal gland.
messages: Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure.

9031:BDNF
gene id: 9031:BDNF
uniprot id: A0A8V0ZCY1
uniprot id: K4MNE5
uniprot id: P25429
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).
messages: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
messages: Secreted

9031:SATB1
gene id: 9031:SATB1
uniprot id: A0A1D5PV61
uniprot id: E1BRH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9031:LOC428293
gene id: 9031:LOC428293
uniprot id: A0A1D5PNR7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:GAL3ST1
gene id: 9031:GAL3ST1
uniprot id: F1NP56
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9031:FAR2
gene id: 9031:FAR2
uniprot id: A0A3Q2TWV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9031:HTR7L
gene id: 9031:HTR7L
uniprot id: D2XUT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:TXLNA
gene id: 9031:TXLNA
uniprot id: A0A3Q3B2W9
names: Similarity
messages: Belongs to the taxilin family.

9031:KCNT1
gene id: 9031:KCNT1
uniprot id: A0A8V1AES6
uniprot id: Q8QFV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily.
messages: Cell membrane
messages: Generates outwardly rectifying currents that are suppressed by elevation of intracellular calcium.
messages: Membrane

9031:SLC30A5
gene id: 9031:SLC30A5
uniprot id: Q5ZLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: COPII-coated vesicle membrane
messages: Golgi stack membrane
messages: Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter.
messages: Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15525635). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635).
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9031:PNO1
gene id: 9031:PNO1
uniprot id: Q5F414
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNO1 family.
messages: Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA.
messages: nucleolus

9031:CHST7
gene id: 9031:CHST7
uniprot id: A0A1D5P3Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9031:LAMP1
gene id: 9031:LAMP1
uniprot id: P05300
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: (Microbial infection) Plays an essential role in efficient replication and spread of Marek's disease virus, by facilitating viral cell-to-cell spread.
messages: Belongs to the LAMP family.
messages: Cell membrane
messages: Cytolytic granule membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis.
messages: Lysosome membrane

9031:SMAD6
gene id: 9031:SMAD6
uniprot id: C3U1W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9031:RPF2
gene id: 9031:RPF2
uniprot id: A0A1D5PVA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

9031:EFNA2
gene id: 9031:EFNA2
uniprot id: P52802
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ephrin family.
messages: Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8 (By similarity).
messages: Cell membrane
messages: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).
messages: Expressed in a gradient across the tectum being more strongly expressed at the posterior pole.

9031:MTOR
gene id: 9031:MTOR
uniprot id: F1NUX4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9031:GPR50
gene id: 9031:GPR50
uniprot id: P49288
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in optic tectum, neostriatum, hypothalamus, thalamus and pineal gland, less in cerebellum and retina.
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).

9031:PRKCA
gene id: 9031:PRKCA
uniprot id: Q5F3X1
uniprot id: R4GHL2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

9031:CLDN20
gene id: 9031:CLDN20
uniprot id: A0A3Q3ANS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9031:CCT6A
gene id: 9031:CCT6A
uniprot id: Q5ZJ54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity).
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

9031:SLC2A5
gene id: 9031:SLC2A5
uniprot id: A0A8V0Z7Z2
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:LOC769755
gene id: 9031:LOC769755
uniprot id: E1BSZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9031:NELL1
gene id: 9031:NELL1
uniprot id: A0A8V0Z6U4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SPRTN
gene id: 9031:SPRTN
uniprot id: E1BQ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9031:FABP3
gene id: 9031:FABP3
uniprot id: F1NUQ3
uniprot id: Q6DRR5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9031:LMBRD2
gene id: 9031:LMBRD2
uniprot id: Q5F3F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: May associate with G-protein coupled receptors and regulate downstream signaling pathways.

9031:RHBDL1
gene id: 9031:RHBDL1
uniprot id: R4GHB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9031:APP
gene id: 9031:APP
uniprot id: Q9DGJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cytoplasm
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus
messages: Secreted

9031:PPP2R2A
gene id: 9031:PPP2R2A
uniprot id: A0A8V0YZY5
uniprot id: Q5ZLP4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9031:RSL24D1
gene id: 9031:RSL24D1
uniprot id: A0A8V0ZM22
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9031:NFS1
gene id: 9031:NFS1
uniprot id: Q5ZKP5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9031:MASP1
gene id: 9031:MASP1
uniprot id: Q6Q1Q8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TA3
gene id: 9031:TA3
uniprot id: Q1G7G9
names: Disease Annotation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TALPID3 family.
messages: Defects in Talpid3 are the cause of the spontaneous mutant with pleiotropic phenotype including polydactylous limbs with many unpatterned digits, vascular defects, hypoteleorism, abnormal dorsoventral patterning of the neural tube, loss of endochondral bone formation and embryonic lethality.
messages: Failure of formation of primary and motile cilia in ependymal cells of the prosencephalic choroid plexus. Centrosomes are rarely found near the cell surface but are often mislocalized deep within the cell and do not show coordinate orientation within group.
messages: Required for ciliogenesis and sonic hedgehog/SHH signaling (PubMed:16702409, PubMed:19144723, PubMed:26386247). Independently, involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (PubMed:26386247).
messages: Ubiquitously expressed.
messages: centrosome

9031:OCM3
gene id: 9031:OCM3
uniprot id: P19753
names: Function
names: Miscellaneous
names: Similarity
messages: Appears to promote immune maturation in bone marrow cells in culture. Binds two calcium ions.
messages: Belongs to the parvalbumin family.
messages: This parvalbumin has an isoelectric point of 4.3.

9031:SEMA3E
gene id: 9031:SEMA3E
uniprot id: O42237
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.
messages: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation (By similarity).
messages: Secreted
messages: Strong binding to neuropilin is mediated by the carboxy third of the protein.

9031:OPN1MSW
gene id: 9031:OPN1MSW
uniprot id: P28683
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: The color pigments are found in the cone photoreceptor cells.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

9031:MLLT11
gene id: 9031:MLLT11
uniprot id: A0A1L1RVM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9031:HIGD2A
gene id: 9031:HIGD2A
uniprot id: F1NUW0
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9031:RXRG
gene id: 9031:RXRG
uniprot id: P28701
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At stage 16, in the posterior trunk region, expressed in the neural crest and in neural crest cells migrating into the sclerotome. From stages 24 to 27, expressed in the liver and in elements of the developing peripheral nervous system derived from the neural crest, including dorsal root ganglia, cranial ganglia, enteric ganglia and peripheral nerve tracts.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.
messages: Isoform 1 is highly expressed inliver. Isoform 2 is abundantly expressed in eye and dorsal root ganglia.
messages: Nucleus
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

9031:LOC107049146
gene id: 9031:LOC107049146
uniprot id: A0A1D5P9Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:CDX4
gene id: 9031:CDX4
uniprot id: Q90Z54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9031:KCNA3
gene id: 9031:KCNA3
uniprot id: Q7T195
names: Subcellular Location Annotation
messages: Membrane

9031:MFSD11
gene id: 9031:MFSD11
uniprot id: E1BSA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9031:SEPTIN7
gene id: 9031:SEPTIN7
uniprot id: A0A8V0Z8F1
uniprot id: Q5F3T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium axoneme
messages: kinetochore
messages: spindle

9031:PNAT10
gene id: 9031:PNAT10
uniprot id: P13913
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9031:DNASE1L3
gene id: 9031:DNASE1L3
uniprot id: Q3Y8N1
names: Similarity
messages: Belongs to the DNase I family.

9031:CAPN8
gene id: 9031:CAPN8
uniprot id: F1P052
names: Similarity
messages: Belongs to the peptidase C2 family.

9031:ELMO1
gene id: 9031:ELMO1
uniprot id: Q5ZL97
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9031:SSBP2
gene id: 9031:SSBP2
uniprot id: A0A8V0XQZ2
uniprot id: F1NTD5
names: Subcellular Location Annotation
messages: Nucleus

9031:TRIM2
gene id: 9031:TRIM2
uniprot id: F1NEW3
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9031:INHBE
gene id: 9031:INHBE
uniprot id: A0A3Q2TUG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9031:TM6SF1
gene id: 9031:TM6SF1
uniprot id: A0A1L1RWK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

9031:UCP3
gene id: 9031:UCP3
uniprot id: Q9DDT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:ANPEP
gene id: 9031:ANPEP
uniprot id: O57579
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity aminopeptidase. Degrades a variety of peptides possessing various N-terminal amino acids including hydrophobic, basic and acidic amino acids. Preferentially hydrolyzes small peptides consisting of 4 or 5 amino acids. Hydrolyzes the N-terminal Xaa-Pro bonds in the chicken brain peptide Leu-Pro-Leu-Arg-PheNH2, the substance P fragment Arg-Pro-Lys-Pro and the bradykinin fragment Arg-Pro-Pro-Gly-Phe. Hydrolyzes the N-formylated peptides fMet-Leu-Phe, fMet-Ala-Gly-Ser-Glu and fMet-Nle-Leu-Phe-Nle-Tyr-Lys, but does not hydrolyze peptides with acetylation or pyroglutamic acid at N-terminus. Does not hydrolyze large peptides such as complete substance P, bradykinin or schistoFLRFamide.
messages: Cell membrane
messages: Detected in the plasma and granule fractions of egg yolk (at protein level).
messages: Homodimer.

9031:DFNB59
gene id: 9031:DFNB59
uniprot id: A0A8V0ZN76
names: Similarity
messages: Belongs to the gasdermin family.

9031:ABCG2
gene id: 9031:ABCG2
uniprot id: E1C5B1
names: Subcellular Location Annotation
messages: Membrane

9031:DDX47
gene id: 9031:DDX47
uniprot id: Q5ZLB0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9031:CHRNA10
gene id: 9031:CHRNA10
uniprot id: Q9I8C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
messages: Cell membrane
messages: Interacts with the conotoxin GeXXA.
messages: Ionotropic receptor with a probable role in the modulation of auditory stimuli.
messages: Postsynaptic cell membrane

9031:PRDX1
gene id: 9031:PRDX1
uniprot id: P0CB50
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer (By similarity). Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (PubMed:19766572). Interacts with SESN1 and SESN2 (By similarity).
messages: Reduced levels of PRDX1 by RNAi cause the loss of motor neurons but did not alter the number of motor neuron progenitors or the dorsal-ventral pattering of spinal progenitors, and did not compromise motor neuron survival.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (PubMed:19766572).

9031:NUMB
gene id: 9031:NUMB
uniprot id: Q9PW30
names: Function
messages: Plays a role in the process of neurogenesis.

9031:BPGM
gene id: 9031:BPGM
uniprot id: A0A8V0YE67
uniprot id: Q5ZHV4
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9031:CLTB
gene id: 9031:CLTB
uniprot id: A0A1D5PL88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9031:IL8L2
gene id: 9031:IL8L2
uniprot id: A3DTN6
uniprot id: P08317
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: By serum. Expressed constitutively in Rous sarcoma virus (RSV) infected cells.
messages: Homodimer.
messages: May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils.
messages: Secreted

9031:EIF2B1
gene id: 9031:EIF2B1
uniprot id: F1NLG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9031:LOC107055286
gene id: 9031:LOC107055286
uniprot id: A0A4Y5F8L7
uniprot id: E1BQM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:RPL34
gene id: 9031:RPL34
uniprot id: A0A1L1S0X5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9031:ALDH5A1
gene id: 9031:ALDH5A1
uniprot id: A0A1D5PFY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

9031:GSDMA
gene id: 9031:GSDMA
uniprot id: Q5ZHP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9031:FGFRL1
gene id: 9031:FGFRL1
uniprot id: Q7T2H2
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in cartilaginous structures.
messages: Has a negative effect on cell proliferation.
messages: Interacts with heparin and FGF2.

9031:SH3PXD2A
gene id: 9031:SH3PXD2A
uniprot id: A0A3Q2U9A8
uniprot id: A0A3Q2U9S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm

9031:CKS1B
gene id: 9031:CKS1B
uniprot id: A0A1L1S0Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9031:SUPT20H
gene id: 9031:SUPT20H
uniprot id: A0A8V0XKQ4
uniprot id: Q5ZM71
names: Function
names: Similarity
messages: Belongs to the SPT20 family.
messages: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation.

9031:SLC2A8
gene id: 9031:SLC2A8
uniprot id: Q8AYP6
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:TSPO
gene id: 9031:TSPO
uniprot id: F1NZA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9031:RBP4A
gene id: 9031:RBP4A
uniprot id: P41263
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.
messages: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
messages: Secreted

9031:TTC39B
gene id: 9031:TTC39B
uniprot id: A0A8V0YWD4
uniprot id: A0A8V0YWD9
names: Similarity
messages: Belongs to the TTC39 family.

9031:ADH6
gene id: 9031:ADH6
uniprot id: O42483
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9031:HDAC4
gene id: 9031:HDAC4
uniprot id: P83038
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

9031:ABHD13
gene id: 9031:ABHD13
uniprot id: Q5ZJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Membrane

9031:DUSP10
gene id: 9031:DUSP10
uniprot id: Q5ZJF8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9031:SLC41A2
gene id: 9031:SLC41A2
uniprot id: F1NWZ7
uniprot id: Q5ZHX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Acts as a plasma-membrane magnesium transporter. Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+).
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Membrane

9031:BRINP1
gene id: 9031:BRINP1
uniprot id: Q7ZZR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRINP family.
messages: Cytoplasm
messages: Plays a role in neurogenesis and brain development. May suppress cell cycle progression in postmitotic neurons by inhibiting G1/S transition.

9031:PTPN3
gene id: 9031:PTPN3
uniprot id: A0A8V0XU97
uniprot id: A0A8V0Y719
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9031:MAP4K5
gene id: 9031:MAP4K5
uniprot id: A0A8V0ZA40
uniprot id: A0A8V0ZA45
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9031:TRPM8
gene id: 9031:TRPM8
uniprot id: Q5UKZ3
names: Subcellular Location Annotation
messages: Membrane

9031:ATP6V0B
gene id: 9031:ATP6V0B
uniprot id: A0A1L1RUN2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9031:WBSCR17
gene id: 9031:WBSCR17
uniprot id: A0A8V1AKY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:GLP2R
gene id: 9031:GLP2R
uniprot id: C4P7J2
names: Subcellular Location Annotation
messages: Membrane

9031:SMYD4
gene id: 9031:SMYD4
uniprot id: Q5F3V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus
messages: Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.

9031:SLC25A37
gene id: 9031:SLC25A37
uniprot id: F1NS09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:MYORG
gene id: 9031:MYORG
uniprot id: F1NB98
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9031:CPNE2
gene id: 9031:CPNE2
uniprot id: E1BQ84
names: Similarity
messages: Belongs to the copine family.

9031:EPCAM
gene id: 9031:EPCAM
uniprot id: Q5F381
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lateral cell membrane

9031:LOC776816
gene id: 9031:LOC776816
uniprot id: Q5ZMQ2
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-73 by SETD3.
messages: N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP.
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9031:PSMC2
gene id: 9031:PSMC2
uniprot id: Q5ZMB8
names: Similarity
messages: Belongs to the AAA ATPase family.

9031:GTF2A1
gene id: 9031:GTF2A1
uniprot id: A1IIE6
uniprot id: Q5F3E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9031:BRF1
gene id: 9031:BRF1
uniprot id: F1NQ85
names: Similarity
messages: Belongs to the TFIIB family.

9031:MEIG1
gene id: 9031:MEIG1
uniprot id: F1NP66
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9031:ITK
gene id: 9031:ITK
uniprot id: A0A8V0YJJ1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9031:BDKRB2
gene id: 9031:BDKRB2
uniprot id: O42402
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9031:DDX27
gene id: 9031:DDX27
uniprot id: Q5ZLD0
names: Similarity
messages: Belongs to the DEAD box helicase family.

9031:ATG9A
gene id: 9031:ATG9A
uniprot id: Q3T8Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9031:NMBR
gene id: 9031:NMBR
uniprot id: E1BRP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:NFIL3
gene id: 9031:NFIL3
uniprot id: Q90Z72
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator (By similarity). Represses PER2 transcription through a recognition sequence in the promoter (PubMed:11427718, PubMed:15182670). Component of the circadian clock that may contribute to the rhythmic expression of PER2 gene in a light-dependent and time-of-day-dependent manner (PubMed:11427718, PubMed:15182670).
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Cytoplasm
messages: Expression is regulated by light and circadian rhythms in the pineal gland (at protein level).
messages: Homodimer (By similarity). Binds DNA as a dimer (By similarity).
messages: Nucleus
messages: Phosphorylated. Phosphorylated on Ser-182. Phosphorylation may require prime phosphorylation(s). Phosphorylation takes place at specific times of the day. Phosphorylation leads to its down-regulation through proteasome-dependent degradation.

9031:CAPN9
gene id: 9031:CAPN9
uniprot id: A0A8V0XTV9
names: Similarity
messages: Belongs to the peptidase C2 family.

9031:P2RY1
gene id: 9031:P2RY1
uniprot id: P34996
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Brain, spinal cord, gastrointestinal tract, spleen and leg muscle. Is not detected in the heart, liver, stomach, lung and kidney.
messages: Cell membrane
messages: Receptor for extracellular adenine nucleotides such as ADP (PubMed:8508924). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity).

9031:PUS10
gene id: 9031:PUS10
uniprot id: E1C8Y6
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

9031:SLC16A10
gene id: 9031:SLC16A10
uniprot id: A0A142EGP8
names: Subcellular Location Annotation
messages: Membrane

9031:ARL4C
gene id: 9031:ARL4C
uniprot id: A0A8V0YAD2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9031:TEAD4
gene id: 9031:TEAD4
uniprot id: P48984
names: Caution
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Enriched in cardiac and skeletal muscle.
messages: Isoform B has probably a transactivation capacity that is lacking in the other isoforms. Isoform D may be defective in DNA binding.
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differentially activate transcription.
messages: Was originally called TEF-1, but is the ortholog of mammalian TEF-3.

9031:MB
gene id: 9031:MB
uniprot id: P02197
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9031:EDN2
gene id: 9031:EDN2
uniprot id: E1C482
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9031:ADCK2
gene id: 9031:ADCK2
uniprot id: F1P1M5
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9031:ORAI1
gene id: 9031:ORAI1
uniprot id: Q5ZL05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores.
messages: Cell membrane

9031:ASL
gene id: 9031:ASL
uniprot id: P05083
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase.
messages: Eye lens.
messages: Homotetramer.
messages: It is uncertain if this gene is expressed.

9031:ATF7IP
gene id: 9031:ATF7IP
uniprot id: Q5ZIE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus
messages: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity. May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity).

9031:ALG12
gene id: 9031:ALG12
uniprot id: F1P077
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:EIF6
gene id: 9031:EIF6
uniprot id: Q5ZL92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: nucleolus

9031:EVX2
gene id: 9031:EVX2
uniprot id: A0A8V1A6N9
names: Subcellular Location Annotation
messages: Nucleus

9031:H2AZ2
gene id: 9031:H2AZ2
uniprot id: A0A8V0ZAA4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:THYN1
gene id: 9031:THYN1
uniprot id: A0A1D5PEL7
uniprot id: Q90679
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed at high levels in bursa of fabricus, thymus and spleen. Also found in the liver, intestine, heart and brain.
messages: Nucleus
messages: Phosphorylated.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
messages: Undergoes proteolytic processing during lymphocyte apoptosis.

9031:NAV2
gene id: 9031:NAV2
uniprot id: A0A8V0ZBW3
uniprot id: A0A8V0ZBX9
uniprot id: A0A8V0ZDC0
uniprot id: A0A8V0ZDC7
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9031:RLN3
gene id: 9031:RLN3
uniprot id: B1AC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9031:EZH2
gene id: 9031:EZH2
uniprot id: A0A8V0XZM3
uniprot id: A0A8V0Y244
uniprot id: A0A8V0Y617
names: Subcellular Location Annotation
messages: Nucleus

9031:WDR82
gene id: 9031:WDR82
uniprot id: Q5ZMV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SWD2 family.
messages: Chromosome
messages: Component of the SET1 complex.
messages: Nucleus
messages: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).

9031:PIK3R5
gene id: 9031:PIK3R5
uniprot id: Q5ZIB8
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Greatly activated by G gamma proteins.
messages: Heterodimer. Interacts with a catalytic subunit and with G beta gamma proteins (By similarity).
messages: Nucleus
messages: Regulatory subunit of the PI3K gamma complex.
messages: The heterodimerization region allows the binding to the catalytic subunit.

9031:HS2ST1
gene id: 9031:HS2ST1
uniprot id: Q76KB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sulfotransferase 3 family.
messages: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes.
messages: Expressed in heart, limb, head and trunk. At stages 20 and 24, it is expressed in the most regions of the first and second pharyngeal arche. In both wing and leg buds, it is detected at the overlying ectoderm and mesenchyme throughout stages 21, 23 and 24.
messages: Golgi apparatus membrane
messages: Homotrimer.

9031:WDR91
gene id: 9031:WDR91
uniprot id: Q5ZLL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport.
messages: Late endosome membrane

9031:PCDHA5
gene id: 9031:PCDHA5
uniprot id: Q6R0I6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:OSBPL6
gene id: 9031:OSBPL6
uniprot id: A0A1D5P5J6
uniprot id: A0A3Q2TY05
uniprot id: A0A8V0ZTQ8
names: Similarity
messages: Belongs to the OSBP family.

9031:ROR1
gene id: 9031:ROR1
uniprot id: A0A8V1A1G5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:UCHL5
gene id: 9031:UCHL5
uniprot id: Q5ZKF1
names: Similarity
messages: Belongs to the peptidase C12 family.

9031:KCNJ15
gene id: 9031:KCNJ15
uniprot id: A0A3Q2TVJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9031:DAO
gene id: 9031:DAO
uniprot id: A0A8V0ZRR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9031:RSPO4
gene id: 9031:RSPO4
uniprot id: E1BVQ0
names: Similarity
messages: Belongs to the R-spondin family.

9031:ALDOC
gene id: 9031:ALDOC
uniprot id: R4GM10
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9031:DHX30
gene id: 9031:DHX30
uniprot id: A0A3Q2UCW3
uniprot id: A0A8V1AFU2
uniprot id: Q5ZI74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Mitochondrion
messages: RNA-dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. Associates with mitochondrial DNA. Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD.
messages: mitochondrion nucleoid

9031:JUN
gene id: 9031:JUN
uniprot id: P18870
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Jun subfamily.
messages: Interacts with FOS to form a dimer. Interacts with Gallid herpesvirus 2 MEQ protein.
messages: Nucleus
messages: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter.

9031:GPCPD1
gene id: 9031:GPCPD1
uniprot id: E1BYP8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:FAM210A
gene id: 9031:FAM210A
uniprot id: Q5ZML6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM210 family.
messages: Cytoplasm
messages: Interacts with ATAD3A.
messages: May play a role in the structure and strength of both muscle and bone.
messages: Membrane
messages: Mitochondrion

9031:HOXD12
gene id: 9031:HOXD12
uniprot id: P24343
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Abd-B homeobox family.
messages: Coordinately expressed in partially overlapping domains during wing development.
messages: Expressed primarily in limb buds.
messages: Interacts with MAF and MAFB.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:GRM7
gene id: 9031:GRM7
uniprot id: A0A8V0Z3V1
uniprot id: A0A8V0ZAF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9031:MAB21L2
gene id: 9031:MAB21L2
uniprot id: A0A8V0XZD8
names: Similarity
messages: Belongs to the mab-21 family.

9031:DDX1
gene id: 9031:DDX1
uniprot id: Q90WU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Acts as a positive regulator of transcription. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Binds DNA and RNA. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB (By similarity). Binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Detected in embryonic retina, brain, heart and liver (at protein level). Detected in embryonic retina, brain, heart, kidney and liver.
messages: Mitochondrion
messages: Nucleus
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.
messages: cytosol

9031:FAM219A
gene id: 9031:FAM219A
uniprot id: A0A8V0Y9Q4
names: Similarity
messages: Belongs to the FAM219 family.

9031:ST6GAL2
gene id: 9031:ST6GAL2
uniprot id: E1BZW3
uniprot id: Q701R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.

9031:SLC6A14
gene id: 9031:SLC6A14
uniprot id: E1C8K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:HIST1H2B7
gene id: 9031:HIST1H2B7
uniprot id: P0C1H3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct.
messages: Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:IFI27L2
gene id: 9031:IFI27L2
uniprot id: Q6IEC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9031:ADAM22
gene id: 9031:ADAM22
uniprot id: A0A8V0XGG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CREBL2
gene id: 9031:CREBL2
uniprot id: A0A8V0ZMN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9031:CEP41
gene id: 9031:CEP41
uniprot id: E1C065
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP41 family.
messages: Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of tubulin polyglutamylases between the basal body and the cilium (By similarity).
messages: centrosome
messages: cilium
messages: cilium basal body

9031:PFDN5
gene id: 9031:PFDN5
uniprot id: A0A1D5NXK7
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9031:ACER1
gene id: 9031:ACER1
uniprot id: A0A8V1AJC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9031:COL14A1
gene id: 9031:COL14A1
uniprot id: P32018
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors.
messages: Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
messages: Homotrimer.
messages: Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates.
messages: May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: Wide tissue distribution; high presence in dense connective tissue in skeletal muscle.
messages: extracellular matrix

9031:KCNA1
gene id: 9031:KCNA1
uniprot id: A0A8V0ZS78
names: Subcellular Location Annotation
messages: Membrane

9031:CCNG1
gene id: 9031:CCNG1
uniprot id: E1BUH6
names: Similarity
messages: Belongs to the cyclin family.

9031:TLE4
gene id: 9031:TLE4
uniprot id: A0A8V0YW01
uniprot id: Q8JIM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9031:BET1
gene id: 9031:BET1
uniprot id: E1BRC4
names: Subcellular Location Annotation
messages: Membrane

9031:ST3GAL1
gene id: 9031:ST3GAL1
uniprot id: Q11200
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Expressed in early embryonic stages.
messages: Golgi stack membrane
messages: Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9031:E2F1
gene id: 9031:E2F1
uniprot id: Q90977
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the E2F/DP family.
messages: Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB1, thus releasing the active complex.
messages: Nucleus
messages: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Positively regulates transcription of RRP1B.

9031:LOC395100
gene id: 9031:LOC395100
uniprot id: Q2TV23
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

9031:SLC12A7
gene id: 9031:SLC12A7
uniprot id: A0A1D5P9V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9031:EDC3
gene id: 9031:EDC3
uniprot id: A0A1D5NZF2
uniprot id: Q5ZLS2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity).
messages: P-body
messages: The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with other proteins (By similarity).

9031:CSNK2A2
gene id: 9031:CSNK2A2
uniprot id: P21869
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling (By similarity).
messages: Tetramer composed of an alpha chain, an alpha' and two beta chains.

9031:SLC43A2
gene id: 9031:SLC43A2
uniprot id: E1C4M9
names: Subcellular Location Annotation
messages: Membrane

9031:OVOA
gene id: 9031:OVOA
uniprot id: Q98UI9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Homomultimer; disulfide-linked (PubMed:5119791). The N- and C-terminus mediate their assembly into higher order structures to form filaments (By similarity). The CTCK domains of two polypeptides associate in the endoplasmic reticulum to generate intermolecularly disulfide-bonded dimers (By similarity). These dimers progress to the Golgi apparatus, which is a more acidic environment than the endoplasmic reticulum. Under acidic conditions, the N-termini form non-covalent intermolecular interactions that juxtapose assemblies from different CTCK-linked dimers to produce long, disulfide-linked polymers that remain highly compact until secretion (By similarity).
messages: N-glycosylated. Complex glycosylation with bisecting N-acetylglucosamine. Contains mainly N-acetylglucosamine (3.1-8.5%), mannose (2.9-4.6%), a small amount of galactose (1.1-4.35) and sialic acid (0.3-1.3%). Most abundant glycan is composed of a GlcNAc(2)Man(3) core, a bisecting GlcNAc and another 3 GlcNAc antannae located on the mannoses of the core. Site Asn-1639 exists both in glycosylated and non-glycosylated forms.
messages: Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6.
messages: Secreted
messages: The CTCK domain mediates interchain disulfide bonds with another molecule of MUC5B.

9031:TSG101
gene id: 9031:TSG101
uniprot id: E1BWW2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

9031:TP63
gene id: 9031:TP63
uniprot id: Q9DEC7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Nucleus

9031:LOC107049174
gene id: 9031:LOC107049174
uniprot id: A0A1D5PQ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9031:CSF2
gene id: 9031:CSF2
uniprot id: Q5W4T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9031:C6orf120
gene id: 9031:C6orf120
uniprot id: F1NYK5
uniprot id: Q5ZLK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: Secreted

9031:MTERF3
gene id: 9031:MTERF3
uniprot id: Q5ZJC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mTERF family.
messages: Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity).
messages: Contains about seven structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a superhelical structure with a solenoid shape (By similarity).
messages: Mitochondrion

9031:PDXK
gene id: 9031:PDXK
uniprot id: A0A8V0YBU4
uniprot id: A0A8V0YFC5
names: Similarity
messages: Belongs to the pyridoxine kinase family.

9031:REEP3
gene id: 9031:REEP3
uniprot id: A0A8V0YA15
uniprot id: F1NBY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9031:GCSH
gene id: 9031:GCSH
uniprot id: P11183
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH). Interacts with GLDC.

9031:ASIC1
gene id: 9031:ASIC1
uniprot id: Q1XA76
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.
messages: Cell membrane
messages: Channel opening involves a conformation change that affects primarily the extracellular domain and the second transmembrane helix and its orientation in the membrane. In the open state, the second transmembrane helix is nearly perpendicular to the plane of the membrane; in the desensitized state it is strongly tilted. Besides, the second transmembrane domain is discontinuously helical in the open state. The GAS motif of the selectivity filter is in an extended conformation, giving rise to a distinct kink in the polypeptide chain. A domain swap between subunits gives rise to a full-length transmembrane helix.
messages: Homotrimer. Interacts with spider venom psalmotoxin 1 with a one to one stoichiometry. Interacts with the heterodimeric snake venom neurotoxin composed of MitTx-alpha and MitTx-beta.
messages: Inhibited by the diuretic amiloride. Inhibited by Cs(1+) ions. Inhibited by the spider venom psalmotoxin-1; this locks the channel into its desensitized conformation. Channel activity is increased by the heterodimeric snake venom neurotoxin composed of MitTx-alpha and MitTx-beta; this slows channel closure and increases the magnitude of the steady-state current that is triggered by low pH.
messages: Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.

9031:ANXA13
gene id: 9031:ANXA13
uniprot id: A0A1D5NUB1
uniprot id: A0A8V0XZA6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9031:SLC13A1
gene id: 9031:SLC13A1
uniprot id: A0A8V0X9P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9031:GCHFR
gene id: 9031:GCHFR
uniprot id: A0A1D5PZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9031:PRPF38B
gene id: 9031:PRPF38B
uniprot id: E1BVP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9031:TM2D3
gene id: 9031:TM2D3
uniprot id: F1NX03
names: Subcellular Location Annotation
messages: Membrane

9031:PAICS
gene id: 9031:PAICS
uniprot id: A0A1D5PH07
uniprot id: P38024
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9031:TUBB6
gene id: 9031:TUBB6
uniprot id: P09653
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:PPP2R5C
gene id: 9031:PPP2R5C
uniprot id: Q5F3C6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

9031:EXOC7
gene id: 9031:EXOC7
uniprot id: Q5ZIN3
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9031:GK2
gene id: 9031:GK2
uniprot id: A0A1D5NV46
uniprot id: A0A8V0X4V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9031:HSPB1
gene id: 9031:HSPB1
uniprot id: Q00649
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer.
messages: Nucleus
messages: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization.
messages: Smooth, cardiac and skeletal muscle, hardly detectable in fibroblasts or focal contacts.
messages: spindle

9031:FAIM2
gene id: 9031:FAIM2
uniprot id: A0A1D5PGL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9031:CNKSR3
gene id: 9031:CNKSR3
uniprot id: A0A8V0XMP1
names: Similarity
messages: Belongs to the CNKSR family.

9031:HM13
gene id: 9031:HM13
uniprot id: A0A8V0YMK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9031:HIRA
gene id: 9031:HIRA
uniprot id: P79987
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat HIR1 family.
messages: Cooperates with ASF1A to promote replication-independent chromatin assembly (By similarity). May regulate the transcription of a variety of genes controlling cell growth.
messages: Expressed from gastrulation onwards with predominant expression in the neuroepithelium during neurulation. Expressed in regions of the embryo containing migrating neural crest cells, particularly those emanating from rhombomeres 4 and 6. Expressed throughout the rostral mesenchyme with higher levels of expression in regions containing neural crest cells. At later stages strong expression is seen in the neural crest derived regions of the head, the branchial arches and the pharyngeal pouches. Expression at the rhombomere boundaries increases around stage 16.
messages: Interacts with ASF1, HDAC1, HDAC2 and RBBP4.
messages: Nucleus

9031:PCDHGA2
gene id: 9031:PCDHGA2
uniprot id: Q6EI13
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:TGFB1
gene id: 9031:TGFB1
uniprot id: H9CX01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

9031:TMEM182
gene id: 9031:TMEM182
uniprot id: A0A8V0YH46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9031:OR1052
gene id: 9031:OR1052
uniprot id: F1NT41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:LRRC8C
gene id: 9031:LRRC8C
uniprot id: A0A8V0ZQA9
uniprot id: E1C957
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9031:HTRA3
gene id: 9031:HTRA3
uniprot id: A0A8V0Y8P6
names: Similarity
messages: Belongs to the peptidase S1C family.

9031:ACVR2B
gene id: 9031:ACVR2B
uniprot id: Q90670
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: By activin.
messages: Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG).
messages: Membrane
messages: Not expressed in hen anterior pituitary during the ovulatory cycle but expressed in the ovarian follicle.
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.

9031:THOC2
gene id: 9031:THOC2
uniprot id: A0A3S5ZP33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

9031:CTDSPL2
gene id: 9031:CTDSPL2
uniprot id: Q5F3Z7
names: Function
names: Similarity
messages: Belongs to the CTDSPL2 family.
messages: Probable phosphatase.

9031:CHMP2B
gene id: 9031:CHMP2B
uniprot id: Q5F3A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).
messages: cytosol

9031:SERINC1
gene id: 9031:SERINC1
uniprot id: Q5ZME5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9031:TSPAN12
gene id: 9031:TSPAN12
uniprot id: Q5ZIF5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP).
messages: Palmitoylated; required for interaction with ADAM10. The precise position of palmitoylated residues is unclear and occurs either on Cys-9, Cys-12 and/or Cys-83 (By similarity).
messages: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity).

9031:SUMO2
gene id: 9031:SUMO2
uniprot id: Q5ZJM9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Polymeric chains can be formed through Lys-11 cross-linking.
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

9031:TMEM229B
gene id: 9031:TMEM229B
uniprot id: Q5F3L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9031:CACNA1B
gene id: 9031:CACNA1B
uniprot id: Q9PUM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

9031:MYO1F
gene id: 9031:MYO1F
uniprot id: Q90748
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:PRXL2A
gene id: 9031:PRXL2A
uniprot id: Q5ZI34
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm
messages: Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass (By similarity).
messages: The active site Cys-88 corresponds to one of the redox-active cysteines of peroxiredoxins.

9031:ISCA1
gene id: 9031:ISCA1
uniprot id: Q5ZJ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
messages: Mitochondrion

9031:DNAJC2
gene id: 9031:DNAJC2
uniprot id: F1P3V8
names: Subcellular Location Annotation
messages: cytosol

9031:TMEM150B
gene id: 9031:TMEM150B
uniprot id: E1C9H3
names: Subcellular Location Annotation
messages: Membrane

9031:HOMER3
gene id: 9031:HOMER3
uniprot id: A0A8V1AJS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9031:CXorf23
gene id: 9031:CXorf23
uniprot id: F1NKX9
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9031:IBSP
gene id: 9031:IBSP
uniprot id: P79780
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity).
messages: It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.
messages: Phosphorylated on serine and threonine residues.
messages: Secreted
messages: Sulfated on either Tyr-272 or Tyr-273.

9031:PKNOX2
gene id: 9031:PKNOX2
uniprot id: Q8AYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9031:LOC396380
gene id: 9031:LOC396380
uniprot id: F1NQS2
uniprot id: P26697
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Alpha family.
messages: Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity.
messages: Cytoplasm
messages: Homodimer or heterodimer (with a subunit from group CL-4).
messages: The variations were found from AA sequencing and imply there are multiple forms of CL-3.

9031:PUM1
gene id: 9031:PUM1
uniprot id: Q2VB19
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Detected in embryonic male and female gonads, heart, liver and muscle. Detected in adult brain, testis, ovary, heart, lung, spleen, kidney and muscle.
messages: P-body
messages: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs.
messages: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. RNA-binding occurs on the concave side of the surface. PUM1 is composed of 8 pumilio repeats of 36 residues; each repeat binds a single nucleotide in its RNA target. Residues at positions 12 and 16 of the pumilio repeat bind each RNA base via hydrogen bonding or van der Waals contacts with the Watson-Crick edge, while the amino acid at position 13 makes a stacking interaction. The recognition of RNA by pumilio repeats is base specific: cysteine and glutamine at position 12 and 16, respectively, bind adenine; asparagine and glutamine bind uracil; and serine and glutamate bind guanine.

9031:MAPK9
gene id: 9031:MAPK9
uniprot id: P79996
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
messages: Expressed in the neuroepithelium of developing brain at stages 16 to 26.
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity).
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

9031:TSPAN18
gene id: 9031:TSPAN18
uniprot id: Q9PTE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:GAL
gene id: 9031:GAL
uniprot id: B9W050
uniprot id: C3V8R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

9031:ASIC5
gene id: 9031:ASIC5
uniprot id: A0A8V0XRY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9031:GPR89A
gene id: 9031:GPR89A
uniprot id: Q5F448
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Golgi apparatus membrane
messages: Homotrimer.
messages: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (By similarity). Plays a role in lymphocyte development (By similarity).

9031:CADM1
gene id: 9031:CADM1
uniprot id: A0A1D5P6B8
names: Similarity
messages: Belongs to the nectin family.

9031:GET4
gene id: 9031:GET4
uniprot id: F1NE90
uniprot id: Q5ZKG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
messages: Belongs to the GET4 family.
messages: Component of the BAG6/BAT3 complex.
messages: cytosol

9031:NCL
gene id: 9031:NCL
uniprot id: P15771
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Highly phosphorylated during mitosis.
messages: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly.
messages: nucleolus

9031:PGM2L1
gene id: 9031:PGM2L1
uniprot id: F1NAA5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9031:HSBP1
gene id: 9031:HSBP1
uniprot id: A0A1D5PAM4
names: Similarity
messages: Belongs to the HSBP1 family.

9031:GPR141
gene id: 9031:GPR141
uniprot id: A0A8V0YXF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:PEX5L
gene id: 9031:PEX5L
uniprot id: A0A8V0Z4Y4
uniprot id: A0A8V0ZBW1
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9031:SSR2
gene id: 9031:SSR2
uniprot id: Q5ZLW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9031:TACR2
gene id: 9031:TACR2
uniprot id: A0A8K1ER17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:RMI2
gene id: 9031:RMI2
uniprot id: Q5ZM20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RMI2 family.
messages: Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM (By similarity).
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
messages: Nucleus

9031:HBS1L
gene id: 9031:HBS1L
uniprot id: A0A8V0XPY1
uniprot id: E1BW59
names: Subcellular Location Annotation
messages: Cytoplasm

9031:POMT1
gene id: 9031:POMT1
uniprot id: A0A8V1A7T6
uniprot id: F1NMM0
uniprot id: Q5ZK29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9031:SGK2
gene id: 9031:SGK2
uniprot id: A0A8V0ZNP7
uniprot id: E1BZK5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:HIST1H4I
gene id: 9031:HIST1H4I
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:LCORL
gene id: 9031:LCORL
uniprot id: Q5ZJK5
names: Function
names: Subcellular Location Annotation
messages: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'.
messages: Nucleus

9031:FAM19A3
gene id: 9031:FAM19A3
uniprot id: A0A8V1A867
names: Similarity
messages: Belongs to the TAFA family.

9031:PHF10
gene id: 9031:PHF10
uniprot id: A0A1D5NX83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

9031:CASC4
gene id: 9031:CASC4
uniprot id: A0A8V0Z264
uniprot id: Q5ZKQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9031:KCNS2
gene id: 9031:KCNS2
uniprot id: A0A1D5PCF8
names: Subcellular Location Annotation
messages: Membrane

9031:TFEC
gene id: 9031:TFEC
uniprot id: Q5XFQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus
messages: Transcriptional regulator that acts as a repressor or an activator. Binds DNA (By similarity).

9031:TP53I3
gene id: 9031:TP53I3
uniprot id: E1C9A2
names: Similarity
messages: Belongs to the profilin family.

9031:ZFX
gene id: 9031:ZFX
uniprot id: F1NQX8
names: Subcellular Location Annotation
messages: Nucleus

9031:ST6GAL1
gene id: 9031:ST6GAL1
uniprot id: Q92182
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Highly expressed in testis, brain and liver and to a lesser extent in lung and heart.
messages: Monomer and homodimer.
messages: N-glycosylated.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.
messages: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

9031:NR1D2
gene id: 9031:NR1D2
uniprot id: Q90970
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:EYA3
gene id: 9031:EYA3
uniprot id: A0A8V0YAP9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9031:PLA2G2E
gene id: 9031:PLA2G2E
uniprot id: D6NKG5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9031:SNF8
gene id: 9031:SNF8
uniprot id: E1BZH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

9031:AvBD10
gene id: 9031:AvBD10
uniprot id: Q6QLQ9
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Detected in the theca and granulosa layers of the ovarian follicle in the white follicle (WF), F1, F3, F5, and postovulatory follicle stages.
messages: Expression in the theca and granulosa layers of the F3 stage ovarian follicle is not affected by intravenous injection of LPS.
messages: Has bactericidal activity.
messages: Secreted
messages: Strong expression in the testis, liver, gall bladder and kidney. Also expressed in the ovary and male and female reproductive tracts. Expressed in the ovarian stroma and the theca and granulosa layers of the ovarian follicle.

9031:HHIP
gene id: 9031:HHIP
uniprot id: A0A1D5PDP9
uniprot id: F1NGW6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PARD6A
gene id: 9031:PARD6A
uniprot id: F1P0U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9031:SF3A3
gene id: 9031:SF3A3
uniprot id: Q5F387
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

9031:PDZD11
gene id: 9031:PDZD11
uniprot id: Q5ZIK2
names: Subcellular Location Annotation
messages: Cytoplasm

9031:STRBP
gene id: 9031:STRBP
uniprot id: Q5ZIL4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in normal spermatogenesis and sperm function. Binds to double-stranded DNA and RNA (By similarity).

9031:GGA2
gene id: 9031:GGA2
uniprot id: A0A8V0Z1L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9031:HPCAL1
gene id: 9031:HPCAL1
uniprot id: P42324
names: Induction
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the recoverin family.
messages: By the MYB-ETS fusion oncogene.
messages: Expressed in hemopoietic cells, but also in the fibroblasts, bone marrow, brain, eye and gut.
messages: Probably binds two or three calcium ions.

9031:ANOS1
gene id: 9031:ANOS1
uniprot id: P33005
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell surface
messages: Mainly expressed in neurons of the central nervous system during the second half of embryonic life. Expressed in mitral neurons of the olfactory bulbs, striatal neurons, Purkinje cells of the cerebellum, retinal neurons and neurons of the brainstem and spinal cord.
messages: May be an adhesion-like molecule with anti-protease activity.

9031:PIK3CD
gene id: 9031:PIK3CD
uniprot id: F1NHX1
uniprot id: Q5F3P4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:SH2D6
gene id: 9031:SH2D6
uniprot id: Q9YGC1
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts through its SH2 domain with CD79A (By similarity). Interacts with VAV3, PLCG2 and GRB2.
messages: Cell membrane
messages: Cytoplasm
messages: Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways (By similarity). Phosphorylation of Tyr-103, Tyr-194 and Tyr-205 facilitates PLCG1 binding. Phosphorylation of Tyr-115 facilitates BTK binding. Phosphorylation of Tyr-91 facilitates VAV1 and NCK1 binding.
messages: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays a critical role in B-cell development in the bursa. Plays an important role in BCR-induced apoptosis.
messages: Highly expressed in the bursa, very low expression in ovary and spleen. Expression was variable among B-cell lines. Highly expressed in immature B-cell lines such as DT40 and CL18, low expression was seen in relatively mature B-cell lines, such as 293B9 and 249L4. No expression was seen in T-cell lines.

9031:KIAA1524
gene id: 9031:KIAA1524
uniprot id: Q5ZMJ7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9031:BMP3
gene id: 9031:BMP3
uniprot id: Q4FAB3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9031:MACIR
gene id: 9031:MACIR
uniprot id: R4GHF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9031:GBX2
gene id: 9031:GBX2
uniprot id: O42230
names: Function
names: Subcellular Location Annotation
messages: May act as a transcription factor for cell pluripotency and differentiation in the embryo.
messages: Nucleus

9031:AP2A2
gene id: 9031:AP2A2
uniprot id: Q5F3T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9031:ATP13A4
gene id: 9031:ATP13A4
uniprot id: Q5ZKB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9031:PANX1
gene id: 9031:PANX1
uniprot id: A0A1D5P0I0
uniprot id: A0A1D5PP45
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9031:GFOD2
gene id: 9031:GFOD2
uniprot id: A0A8V0ZVE4
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9031:CSTB
gene id: 9031:CSTB
uniprot id: F1NHH1
names: Similarity
messages: Belongs to the cystatin family.

9031:GLI3
gene id: 9031:GLI3
uniprot id: Q9DF31
uniprot id: Q9IA31
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Detected in limb buds at embryonic stages 22-23 (at protein level).
messages: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor.
messages: Nucleus
messages: Phosphorylation is essential for its proteolytic processing.
messages: The repressor form (GLI3R), a C-terminally truncated form is generated from the full-length GLI3 protein (GLI3FL) through proteolytic processing.

9031:PPTC7
gene id: 9031:PPTC7
uniprot id: A0A8V1A8D0
names: Similarity
messages: Belongs to the PP2C family.

9031:FLOT2
gene id: 9031:FLOT2
uniprot id: Q5ZHQ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane

9031:C5H14orf4
gene id: 9031:C5H14orf4
uniprot id: A0A1D5NX91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9031:DNAJB6
gene id: 9031:DNAJB6
uniprot id: Q5F3Z5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity.
messages: Homooligomer.
messages: Nucleus
messages: perinuclear region

9031:UNK
gene id: 9031:UNK
uniprot id: A0A8V1AFE2
uniprot id: F1P3C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unkempt family.
messages: Cytoplasm

9031:DUSP29
gene id: 9031:DUSP29
uniprot id: A0A8V0ZQ53
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9031:COG3
gene id: 9031:COG3
uniprot id: F1NXB9
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9031:ALG10
gene id: 9031:ALG10
uniprot id: Q5ZKB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Membrane

9031:NCALD
gene id: 9031:NCALD
uniprot id: P62758
names: Function
names: Similarity
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).

9031:C5orf24
gene id: 9031:C5orf24
uniprot id: A0A8V0YCG8
names: Similarity
messages: Belongs to the UPF0461 family.

9031:HS3ST3B1L
gene id: 9031:HS3ST3B1L
uniprot id: A0A8V1AQB3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:HMGB3
gene id: 9031:HMGB3
uniprot id: P40618
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome
messages: Cytoplasm
messages: Found in newly hatched chick liver and decreases during postnatal development.
messages: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Binds to the delta-1 crystallin/ASL1 enhancer (PubMed:7904558). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity).
messages: Nucleus
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-104 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB3 (HMGB3C23hC45hC104h), 2- disulfide HMGB3 (HMGB3C23-C45C104h) and 3- sulfonyl HMGB3 (HMGB3C23soC45soC104so).

9031:NCBP2
gene id: 9031:NCBP2
uniprot id: A0A1D5NX82
uniprot id: F1NIR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9031:PCBD1
gene id: 9031:PCBD1
uniprot id: O73930
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
messages: Cytoplasm
messages: Homotetramer and homodimer.
messages: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription (By similarity).
messages: Nucleus
messages: The major tissues expressing cDcoH are hypothalamus, kidney and liver.

9031:PLPPR5
gene id: 9031:PLPPR5
uniprot id: A0A8V0ZZM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9031:DNPEP
gene id: 9031:DNPEP
uniprot id: Q5ZJ47
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9031:TECRL
gene id: 9031:TECRL
uniprot id: A0A1D5P442
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9031:PRKCH
gene id: 9031:PRKCH
uniprot id: F1NJH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9031:GTF2B
gene id: 9031:GTF2B
uniprot id: A0A1D5P699
uniprot id: F1NXP2
names: Similarity
messages: Belongs to the TFIIB family.

9031:CCK
gene id: 9031:CCK
uniprot id: A0A023UDZ9
uniprot id: Q9PU41
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the gastrin/cholecystokinin family.
messages: By dietary protein, amino acids and medium-chain triacylglycerol.
messages: In the small intestine, the major production site is around the vitelline diverticulum.
messages: Secreted
messages: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
messages: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.

9031:FAM69A
gene id: 9031:FAM69A
uniprot id: A0A1D5PQJ3
names: Similarity
messages: Belongs to the DIPK family.

9031:EEF1A1
gene id: 9031:EEF1A1
uniprot id: Q90835
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation.

9031:TAF8
gene id: 9031:TAF8
uniprot id: Q5ZMS1
uniprot id: R4GIW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF8 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs).
messages: Cytoplasm
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs). Mediates both basal and activator-dependent transcription.

9031:RPS17
gene id: 9031:RPS17
uniprot id: P08636
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS17 family.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: nucleolus

9031:GRM3
gene id: 9031:GRM3
uniprot id: E1BUE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9031:TMEM170A
gene id: 9031:TMEM170A
uniprot id: Q5ZM31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Endoplasmic reticulum membrane
messages: May regulate membrane morphogenesis in the endoplasmic reticulum (ER) by promoting ER sheet formation at the expense of ER tubules.
messages: Nucleus envelope

9031:AADACL3C
gene id: 9031:AADACL3C
uniprot id: F1P4H5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9031:ARL2BP
gene id: 9031:ARL2BP
uniprot id: Q5ZKW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.
messages: centrosome
messages: cilium basal body
messages: spindle

9031:FAM234B
gene id: 9031:FAM234B
uniprot id: Q5F3L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM234 family.
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

9031:LBFABP
gene id: 9031:LBFABP
uniprot id: A0A140T8G0
uniprot id: P80226
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Binds 2 molecules of cholate per subunit.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9031:OLFM1
gene id: 9031:OLFM1
uniprot id: Q9IAK4
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Contributes to the regulation of axonal growth (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube.
messages: Endoplasmic reticulum
messages: Expressed in a graded pattern in the closing neural tube. Subsequently becomes restricted to the dorsal neural folds and migrating neural crest.
messages: Glycosylated.
messages: Homotetramer; disulfide-linked. Dimer of dimers, giving rise to a V-shaped homotretramer. Component of the AMPAR complex.
messages: Perikaryon
messages: Secreted
messages: Synapse
messages: The protein contains a globular N-terminal tetramerization domain, a long stalk formed by the coiled coil region and a C-terminal olfactomedin-like domain. Interactions between dimers are mediated by the coiled coil region. The dimers interact mostly via the N-terminal tetramerization domain, giving rise to a V-shaped overall architecture of the tetramer.
messages: axon

9031:SEC31A
gene id: 9031:SEC31A
uniprot id: Q5F3X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC31 family.
messages: COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity).
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane

9031:GMFB
gene id: 9031:GMFB
uniprot id: Q5ZJ22
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9031:ATP6V0A4
gene id: 9031:ATP6V0A4
uniprot id: A0A1D5PCU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9031:ENTPD3
gene id: 9031:ENTPD3
uniprot id: A0A1D5PVS9
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9031:PTAR1
gene id: 9031:PTAR1
uniprot id: A0A3Q2U8C8
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9031:GSX1
gene id: 9031:GSX1
uniprot id: A0A1D5PL43
names: Subcellular Location Annotation
messages: Nucleus

9031:SMC3
gene id: 9031:SMC3
uniprot id: Q8AWB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

9031:BZW1
gene id: 9031:BZW1
uniprot id: Q5ZLT7
names: Function
names: Similarity
messages: Belongs to the BZW family.
messages: Translation initiation regulator which may repress repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity).

9031:COQ10A
gene id: 9031:COQ10A
uniprot id: A0A8V1A0Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9031:CHST10
gene id: 9031:CHST10
uniprot id: Q5ZIE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sulfotransferase 2 family.
messages: Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult (By similarity).
messages: Golgi apparatus membrane
messages: Predominantly expressed in hypertrophic, prehypertrophic and proliferative chondrocytes at E12 but is down-regulated in epiphyseal chondrocytes.

9031:ACTR6
gene id: 9031:ACTR6
uniprot id: Q9DEE9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP6 subfamily.
messages: Expressed abundantly in the early developmental stages.
messages: Interacts with CBX1 and CBX3.
messages: Nucleus
messages: Required for formation and/or maintenance of the proper nucleolar structure and function (By similarity). Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription (PubMed:26164235). In the presence of high glucose, it maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z (PubMed:26164235).
messages: cytoskeleton
messages: nucleolus

9031:SLC12A2
gene id: 9031:SLC12A2
uniprot id: A0A1D5PPU2
uniprot id: F1NR57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9031:HHIPL1
gene id: 9031:HHIPL1
uniprot id: A0A1D5NYI4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GUCY1B3
gene id: 9031:GUCY1B3
uniprot id: A0A8V0XVV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9031:IL5RA
gene id: 9031:IL5RA
uniprot id: A0A8V0ZEG3
uniprot id: G1UHB7
uniprot id: R4GKR1
names: Subcellular Location Annotation
messages: Membrane

9031:NT5C3A
gene id: 9031:NT5C3A
uniprot id: A0A1D5PVS5
uniprot id: Q5ZID6
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: By norepinephrine/NE and adenosine which are released by the embryo under hypoxic conditions. By stimulation of beta-adrenergic/adenosine receptors in definitive red blood cells (RBC).
messages: Cytoplasm
messages: Expressed at low levels until 13 dpc and the expression rises transiently between 13 dpc and 16 dpc.
messages: Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.

9031:THRSP
gene id: 9031:THRSP
uniprot id: Q6Q127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9031:INS
gene id: 9031:INS
uniprot id: P67970
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

9031:GNG12
gene id: 9031:GNG12
uniprot id: R4GFT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9031:KRT13
gene id: 9031:KRT13
uniprot id: A0A8V0ZSB0
names: Similarity
messages: Belongs to the intermediate filament family.

9031:SPINK7
gene id: 9031:SPINK7
uniprot id: P01005
names: Allergen
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Avian ovomucoid consists of three homologous, tandem Kazal family inhibitory domains.
messages: Causes an allergic reaction in human.
messages: Secreted
messages: Serine protease inhibitor. Inhibits trypsin.

9031:NIP7
gene id: 9031:NIP7
uniprot id: E1C494
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9031:LRRC8D
gene id: 9031:LRRC8D
uniprot id: E1BYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9031:TM9SF2L
gene id: 9031:TM9SF2L
uniprot id: Q5ZLM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9031:SIK1
gene id: 9031:SIK1
uniprot id: Q9IA88
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by phosphorylation on Thr-181.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm
messages: Phosphorylated at Thr-181 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
messages: Phosphorylates IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity).
messages: Ubiquitously expressed in embryonic tissue.

9031:NEMP1
gene id: 9031:NEMP1
uniprot id: A0A1D5PS15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9031:FTO
gene id: 9031:FTO
uniprot id: D7REI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fto family.
messages: Cytoplasm
messages: Nucleus speckle

9031:NPPA
gene id: 9031:NPPA
uniprot id: P18908
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Cleaved by CORIN upon secretion to produce the functional hormone.
messages: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).
messages: Secreted

9031:CYGB
gene id: 9031:CYGB
uniprot id: Q5QRU7
names: Similarity
messages: Belongs to the globin family.

9031:ARID5B
gene id: 9031:ARID5B
uniprot id: Q5ZJ69
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARID5B family.
messages: Nucleus
messages: The ARID domain mediates the interaction with DNA.
messages: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes (By similarity).

9031:IDH3B
gene id: 9031:IDH3B
uniprot id: Q5ZKN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9031:PPT1
gene id: 9031:PPT1
uniprot id: Q5ZJT3
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9031:MCEE
gene id: 9031:MCEE
uniprot id: E1BSK7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9031:ADRA1B
gene id: 9031:ADRA1B
uniprot id: A0A6J3ZXA9
uniprot id: F1NIZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

9031:MTMR10
gene id: 9031:MTMR10
uniprot id: A0A3Q2TXM8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9031:VMO1
gene id: 9031:VMO1
uniprot id: P41366
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VMO1 family.
messages: Exact function not known, component of the outer membrane of the vitelline layer of the egg. Seems to be able to synthesize N-acetylchito-oligosaccharides (n=14-15) from hexasaccharides of N-acetylglucosamine in a manner similar to the transferase activity of lysozyme.
messages: Secreted

9031:EPHA3
gene id: 9031:EPHA3
uniprot id: P29318
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylates upon activation by EFNA5.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
messages: Cell membrane
messages: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
messages: Highly expressed in the developing brain and embryonic tissues. In adult, the greatest levels of expression occur in the brain. It is expressed in a graded manner across the retina with the highest expression at its temporal pole. Detectable in all other adult tissues examined, except the liver.
messages: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

9031:SNX17
gene id: 9031:SNX17
uniprot id: A0A1D5NVF3
uniprot id: A0A8V0Y440
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9031:MTR
gene id: 9031:MTR
uniprot id: Q5ZIC7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

9031:IFITM5
gene id: 9031:IFITM5
uniprot id: E1BRS4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9031:CST3
gene id: 9031:CST3
uniprot id: P01038
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted
messages: This protein binds tightly to and inhibits a variety of thiol proteases including ficin, papain, and cathepsins B, C, H, and L. Although isolated from egg white, it is also present in serum.

9031:ABCC3
gene id: 9031:ABCC3
uniprot id: F1NM51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9031:SEC24B
gene id: 9031:SEC24B
uniprot id: Q5ZM67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9031:GABRR2
gene id: 9031:GABRR2
uniprot id: F1ND90
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:DYRK2
gene id: 9031:DYRK2
uniprot id: Q5ZIU3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylates on tyrosine residues.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Cytoplasm
messages: Interacts with MDM2.
messages: Nucleus
messages: Phosphorylated on serine/threonine residues. Phosphorylation on Thr-31 and Ser-367 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasome degradation, thus promoting p53/TP53-mediated apoptosis (By similarity).
messages: Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development.
messages: Ubiquitination in nucleus by MDM2 in normal conditions leads to proteasome degradation.

9031:FN3K
gene id: 9031:FN3K
uniprot id: E1BRW8
names: Similarity
messages: Belongs to the fructosamine kinase family.

9031:LIN7C
gene id: 9031:LIN7C
uniprot id: Q5F425
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules.
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains (By similarity). The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
messages: The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
messages: The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
messages: The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.

9031:MTHFD2
gene id: 9031:MTHFD2
uniprot id: Q5ZKA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Mitochondrion

9031:TMC2
gene id: 9031:TMC2
uniprot id: Q5YCC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9031:GBP
gene id: 9031:GBP
uniprot id: Q90892
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9031:IGFBP2
gene id: 9031:IGFBP2
uniprot id: P49705
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: Expressed in embryonic day-15 eye, brain, skeletal muscle, heart and intestine, but virtually absent from embryonic day-15 liver.
messages: Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Secreted
messages: The C-terminus is required for IGF-binding and growth inhibition.

9031:RCL1
gene id: 9031:RCL1
uniprot id: E1C1K6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

9031:RPS13
gene id: 9031:RPS13
uniprot id: Q6ITC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: nucleolus

9031:SRP19
gene id: 9031:SRP19
uniprot id: F1NQ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9031:EXOC6
gene id: 9031:EXOC6
uniprot id: A0A8V0Z436
uniprot id: A0A8V0ZB11
uniprot id: Q5ZJ05
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9031:WNT10A
gene id: 9031:WNT10A
uniprot id: Q60GF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:RPAIN
gene id: 9031:RPAIN
uniprot id: A0A8V1AMS6
names: Subcellular Location Annotation
messages: Nucleus

9031:MSMO1
gene id: 9031:MSMO1
uniprot id: Q5ZLL6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol.
messages: Endoplasmic reticulum membrane
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

9031:ZBTB7A
gene id: 9031:ZBTB7A
uniprot id: O93567
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation. Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ and in alternative splicing (By similarity).

9031:TSSC1
gene id: 9031:TSSC1
uniprot id: Q5ZIB3
names: Similarity
messages: Belongs to the WD repeat EIPR1 family.

9031:WT1
gene id: 9031:WT1
uniprot id: Q9I8A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

9031:ASRGL1
gene id: 9031:ASRGL1
uniprot id: F1P5N7
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9031:GXYLT1
gene id: 9031:GXYLT1
uniprot id: Q5ZKI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
messages: Membrane

9031:NEK7
gene id: 9031:NEK7
uniprot id: Q5F3P1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:BDKRB1
gene id: 9031:BDKRB1
uniprot id: Q38Q38
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9031:YOD1
gene id: 9031:YOD1
uniprot id: Q5F3A6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.

9031:SKAP2
gene id: 9031:SKAP2
uniprot id: A0A3Q2TSS2
names: Similarity
messages: Belongs to the SKAP family.

9031:LINGO1
gene id: 9031:LINGO1
uniprot id: Q50L44
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Expressed broadly in the spinal cord, including the ventral portion of the ventricular zone, and motor neurons. Expressed also in the dorsal root ganglion and boundary cap cells at dorsal and ventral roots. In the early embryonic brain, is first expressed in the prosencephalon and the ventral mesencephalon, and later in the telencephalon, the rostral part of the mesencephalon and some parts of the hindbrain. Expressed also in the ventral part of the neural retina and trigeminal and facial nerves.
messages: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity).
messages: Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19 (By similarity).
messages: N-glycosylated. Contains predominantly high-mannose glycans (By similarity).

9031:FAM96B
gene id: 9031:FAM96B
uniprot id: E1BWV0
names: Similarity
messages: Belongs to the MIP18 family.

9031:HIBCH
gene id: 9031:HIBCH
uniprot id: Q5ZJ60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity).
messages: Mitochondrion

9031:HTR4
gene id: 9031:HTR4
uniprot id: A0A8V0XYF9
uniprot id: F1NJL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

9031:RARB
gene id: 9031:RARB
uniprot id: P22448
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: By retinoic acid.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Heterodimer; with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.
messages: In the developing embryo, expressed in the limb bud mesenchyme, in cranofacial mesenchyme, and in hindbrain neuroectoderm. At stages 20, 24 and 28 of embryonic development, expressed ununiformly in facial primordia. Present in lateral nasal processes, at edges and corners of frontonasal mass and in the anterior part of the maxillary primordia. Expressed in mesenchyme at all stages of facial development. In the developing limb, isoform Beta-1 is expressed limb bud mesenchyme and ectoderm, then become restricted within perichondrial regions and loose connective tissue of the limb, while isoform Beta-2, expressed in subsets of similar tissues, in the proximal limb mesenchyme and in the initial mesenchymal condensate. later abundantly expressed in cells lateral to the digit cartilage.
messages: Nucleus
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for limb and craniofacial development.

9031:PRRC1
gene id: 9031:PRRC1
uniprot id: Q5F3I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

9031:METTL16
gene id: 9031:METTL16
uniprot id: Q5ZIA0
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Methyltransferase activity is autoinhibited by the K-loop region that blocks S-adenosyl-L-methionine-binding. Upon activation, K-loop changes conformation, allowing S-adenosyl-L-methionine-binding and subsequent methyltransferase activity. mRNA N6-adenosine-methyltransferase activity is inhibited by zinc.
messages: Nucleus
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A splicing and protein expression. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs.
messages: The K-loop region occludes the S-adenosyl-L-methionine-binding pocket. Upon activation, conformation of the K-loop changes, allowing S-adenosyl-L-methionine-binding.
messages: The VCR (vertebrate conserved) regions bind the first hairpin of MAT2A mRNAs. The VCR regions interact with the internal stem-loop within U6 snRNAs, inducing the conformational rearrangement of the A43-containing region of U6 snRNA, thereby modifying the RNA structure to become suitable for productive catalysis by the methyltransferase region.

9031:NCSTN
gene id: 9031:NCSTN
uniprot id: Q5ZJB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9031:MX1
gene id: 9031:MX1
uniprot id: B2X026
uniprot id: Q90597
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By interferons.
messages: Cytoplasm
messages: Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus.

9031:KDM3A
gene id: 9031:KDM3A
uniprot id: Q5ZIX8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9031:TP53I11
gene id: 9031:TP53I11
uniprot id: F1NS21
names: Subcellular Location Annotation
messages: Membrane

9031:MVP
gene id: 9031:MVP
uniprot id: Q5ZMI4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Nucleus
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity).
messages: The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).

9031:DSCR3
gene id: 9031:DSCR3
uniprot id: E1BSI1
names: Similarity
messages: Belongs to the VPS26 family.

9031:FAM124A
gene id: 9031:FAM124A
uniprot id: A0A1D5NXK4
names: Similarity
messages: Belongs to the FAM124 family.

9031:BARHL1
gene id: 9031:BARHL1
uniprot id: A0A1D5PMT7
names: Subcellular Location Annotation
messages: Nucleus

9031:PHOSPHO1
gene id: 9031:PHOSPHO1
uniprot id: O73884
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
messages: Expressed at sites of mineralization in bone and cartilage. Highly expressed in hypertrophic chondrocytes compared to non-chondrogenic tissues. Expressed in chondrocytes but not in heart, liver, lung, kidney, spleen, muscle, adipose tissues not duodenum. In diaphyseal cortical bone, it is expressed in the osteoid layer of the periosteum, forming surfaces of growing osteons, and newly formed osteocytes, whereas it is not expressed in the endosteum and closed osteons. In growth plate cartilage, it is limited to the early hypertrophic chondrocytes and the ossification groove of Ranvier. Highly expressed on the mineralization surfaces of the cartilage remnants and trabecular bone within the primary spongiosa. Expressed in 17-day-old embryonic calvaria, the osteoid present on the intramembranous and periosteal bone surfaces but not in soft tissues examined.
messages: Extracellular vesicle
messages: Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (By similarity). Involved in the generation of inorganic phosphate for bone mineralization (PubMed:15050893).
messages: Up-regulated 5-fold during chondrocyte terminal differentiation.

9031:WARS
gene id: 9031:WARS
uniprot id: E1C2Z5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9031:AMDHD2
gene id: 9031:AMDHD2
uniprot id: F1P5J8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

9031:MYH7B
gene id: 9031:MYH7B
uniprot id: Q8UWA0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:RUNX2
gene id: 9031:RUNX2
uniprot id: Q8UVG3
names: Subcellular Location Annotation
messages: Nucleus

9031:DUS4L
gene id: 9031:DUS4L
uniprot id: F1NHN2
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9031:ABCG8
gene id: 9031:ABCG8
uniprot id: A0A8V0ZKE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9031:FAM3C
gene id: 9031:FAM3C
uniprot id: E1BWA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9031:VIPAS39
gene id: 9031:VIPAS39
uniprot id: A0A1D5NXV6
uniprot id: A0A8V0XMY8
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Endosome
messages: Late endosome

9031:NFIC
gene id: 9031:NFIC
uniprot id: Q90930
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9031:CLCN4
gene id: 9031:CLCN4
uniprot id: A0A8V0XDV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9031:DSCC1
gene id: 9031:DSCC1
uniprot id: A0A8V0Y5P3
names: Similarity
messages: Belongs to the DCC1 family.

9031:FANCC
gene id: 9031:FANCC
uniprot id: F1NYH1
uniprot id: Q5F3H0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.
messages: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
messages: Nucleus

9031:PRKCE
gene id: 9031:PRKCE
uniprot id: A0A8V0Z776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9031:BIRC8
gene id: 9031:BIRC8
uniprot id: Q8UVF8
names: Similarity
messages: Belongs to the IAP family.

9031:HHEX
gene id: 9031:HHEX
uniprot id: Q05502
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: In all hematopoietic tissues except peripheral blood erythrocytes and in the liver and lung.
messages: Nucleus
messages: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation.

9031:TUBAL3
gene id: 9031:TUBAL3
uniprot id: F1P5B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:UBE2N
gene id: 9031:UBE2N
uniprot id: Q5F405
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:TMPO
gene id: 9031:TMPO
uniprot id: A0A1L1RX46
uniprot id: A0A8V0YNJ5
uniprot id: A0A8V0YQB2
uniprot id: A0A8V0YQC3
uniprot id: Q5ZMN6
names: Similarity
messages: Belongs to the LEM family.

9031:ANO5
gene id: 9031:ANO5
uniprot id: A0A8V0Z6Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9031:ADMP
gene id: 9031:ADMP
uniprot id: Q9PVK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9031:OAF
gene id: 9031:OAF
uniprot id: Q71SY6
names: Similarity
messages: Belongs to the OAF family.

9031:CNOT1
gene id: 9031:CNOT1
uniprot id: A0A8V0ZE30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9031:SMPD2
gene id: 9031:SMPD2
uniprot id: A0A1D5PL80
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9031:ATP1A1
gene id: 9031:ATP1A1
uniprot id: P09572
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Phosphorylation on Tyr-10 modulates pumping activity.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
messages: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
messages: sarcolemma

9031:ATE1
gene id: 9031:ATE1
uniprot id: Q5F446
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9031:POLR2E
gene id: 9031:POLR2E
uniprot id: F1NHV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

9031:SNRPF
gene id: 9031:SNRPF
uniprot id: A0A1L1RSB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9031:GABRB3
gene id: 9031:GABRB3
uniprot id: P19019
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
messages: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA- gated ion channel (By similarity).
messages: Postsynaptic cell membrane

9031:TMEM17
gene id: 9031:TMEM17
uniprot id: E1BY51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM17 family.
messages: Part of the tectonic-like complex (also named B9 complex).
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: cilium membrane

9031:OPN4-1
gene id: 9031:OPN4-1
uniprot id: A0A1D5NZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9031:ARCN1
gene id: 9031:ARCN1
uniprot id: Q5ZL57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

9031:BOLA3
gene id: 9031:BOLA3
uniprot id: A0A3Q3A7C9
names: Similarity
messages: Belongs to the BolA/IbaG family.

9031:ANAPC5
gene id: 9031:ANAPC5
uniprot id: Q5ZKK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Nucleus
messages: The APC/C is composed of at least 12 subunits.
messages: spindle

9031:A1CF
gene id: 9031:A1CF
uniprot id: A0A8V0ZPX5
names: Subcellular Location Annotation
messages: Cytoplasm

9031:RAG1
gene id: 9031:RAG1
uniprot id: P24271
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination (By similarity).
messages: Homodimer. Component of the RAG complex composed of core components RAG1 and RAG2 (By similarity).
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.
messages: The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity.

9031:MAP6
gene id: 9031:MAP6
uniprot id: O73737
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: In the embryo is expressed in the developing hindbrain and is accumulated in rhombomere boundary regions and in the rhombomere 2, 4 and 6.
messages: Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (By similarity).
messages: cytoskeleton

9031:SNX32
gene id: 9031:SNX32
uniprot id: A0A8V0XTK5
uniprot id: Q5ZK22
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9031:RCOR3
gene id: 9031:RCOR3
uniprot id: Q5ZJ40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoREST family.
messages: May act as a component of a corepressor complex that represses transcription.
messages: Nucleus

9031:SLC9A2
gene id: 9031:SLC9A2
uniprot id: E1BV56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9031:REEP2
gene id: 9031:REEP2
uniprot id: A0A8V0YGX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9031:MYH1A
gene id: 9031:MYH1A
uniprot id: Q8AY28
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:KBP
gene id: 9031:KBP
uniprot id: P19439
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

9031:ACE
gene id: 9031:ACE
uniprot id: Q10751
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 3 chloride ions per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity (By similarity). Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates (By similarity). Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin (By similarity). Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response (By similarity). Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins (By similarity). Catalyzes degradation of different enkephalin neuropeptides (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Phe and possibly Met-enkephalin-Arg-Gly-Leu) (By similarity). Also acts as a regulator of hematopoietic stem cell differentiation by mediating degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) (By similarity).

9031:BLK
gene id: 9031:BLK
uniprot id: A0A3Q2U1T2
uniprot id: E1BYL7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9031:ATG7
gene id: 9031:ATG7
uniprot id: Q5ZKY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (By similarity). Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress (By similarity). Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity).
messages: Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5 (By similarity).
messages: Preautophagosomal structure
messages: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.

9031:SPPL2C
gene id: 9031:SPPL2C
uniprot id: Q5F383
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.
messages: Lysosome membrane
messages: Membrane
messages: The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP.

9031:LPIN2
gene id: 9031:LPIN2
uniprot id: E1C3E3
names: Similarity
messages: Belongs to the lipin family.

9031:CA5A
gene id: 9031:CA5A
uniprot id: A0A8V0YA50
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9031:SDR42E2
gene id: 9031:SDR42E2
uniprot id: E1C196
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9031:SLC2A14
gene id: 9031:SLC2A14
uniprot id: P28568
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Deoxyglucose transport is inhibit by D-glucose, D-galactose and maltose. Galactose transport is inhibited by D-glucose and maltose.
messages: Facilitative glucose transporter. Can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Required for mesendoderm differentiation (By similarity).
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9031:EPHA1
gene id: 9031:EPHA1
uniprot id: Q98TD0
names: Subcellular Location Annotation
messages: Membrane

9031:CAPZA3
gene id: 9031:CAPZA3
uniprot id: E1BUP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9031:LOC101751545
gene id: 9031:LOC101751545
uniprot id: A0A3Q3AQ26
uniprot id: A0A3S5ZPH6
uniprot id: R4GLR2
names: Similarity
messages: Belongs to the CDI family.

9031:PCK1
gene id: 9031:PCK1
uniprot id: P05153
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one.
messages: Monomer.
messages: Phosphoenolpyruvate carboxykinase activity is regulated by glucose levels (By similarity). Phosphorylation at Ser-90 reduces the binding affinity to oxaloacetate and converts the enzyme into an atypical protein kinase using GTP as donor (By similarity).
messages: Phosphorylation at Ser-90 reduces the binding affinity to oxaloacetate and promotes the protein kinase activity.
messages: Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor.

9031:ORAI3
gene id: 9031:ORAI3
uniprot id: Q5ZLW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
messages: Membrane

9031:CHSY1
gene id: 9031:CHSY1
uniprot id: A0A8V0Z8G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9031:TFEB
gene id: 9031:TFEB
uniprot id: Q5ZM43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9031:FEM1B
gene id: 9031:FEM1B
uniprot id: Q5ZM55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fem-1 family.
messages: Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex.
messages: Cytoplasm
messages: Nucleus
messages: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, leading to their ubiquitination and degradation.

9031:CPT1A
gene id: 9031:CPT1A
uniprot id: Q6B842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9031:ACYP2
gene id: 9031:ACYP2
uniprot id: P07031
names: Function
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Its physiological role is not yet clear.

9031:ACLY
gene id: 9031:ACLY
uniprot id: A0A1D5PSE5
uniprot id: Q5F3V2
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9031:FAM46C
gene id: 9031:FAM46C
uniprot id: Q5ZL95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TENT family.
messages: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression.
messages: Cytoplasm
messages: Nucleus
messages: centrosome

9031:FCF1
gene id: 9031:FCF1
uniprot id: A0A1L1RUD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9031:SCD
gene id: 9031:SCD
uniprot id: Q9YGM2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9031:CNGA3
gene id: 9031:CNGA3
uniprot id: Q90805
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
messages: Membrane
messages: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors.

9031:CCLL4
gene id: 9031:CCLL4
uniprot id: Q5IEZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:FCER1G
gene id: 9031:FCER1G
uniprot id: A0PFW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9031:SIAH2
gene id: 9031:SIAH2
uniprot id: E1C3Q9
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9031:NKX2-6
gene id: 9031:NKX2-6
uniprot id: O13053
names: Subcellular Location Annotation
messages: Nucleus

9031:TNFAIP8L1
gene id: 9031:TNFAIP8L1
uniprot id: Q5ZJU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNFAIP8 family.
messages: Cytoplasm

9031:ADAMTS3
gene id: 9031:ADAMTS3
uniprot id: F1NVD1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:IGFBP5
gene id: 9031:IGFBP5
uniprot id: F1ND88
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:CGAS
gene id: 9031:CGAS
uniprot id: A0A8V0X930
names: Similarity
messages: Belongs to the mab-21 family.

9031:TAF1B
gene id: 9031:TAF1B
uniprot id: Q5ZJR9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (By similarity).
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity).
messages: nucleolus

9031:CYP2C18
gene id: 9031:CYP2C18
uniprot id: Q8QFT4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:HVCN1
gene id: 9031:HVCN1
uniprot id: Q5F4C0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Cell membrane
messages: Homodimer.
messages: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).
messages: Membrane
messages: The C-terminal coiled coil region mediates homodimerization. It is essential for normal subcellular localization (By similarity).
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain (By similarity).

9031:MYOZ1
gene id: 9031:MYOZ1
uniprot id: A0A8V0ZIK7
names: Similarity
messages: Belongs to the myozenin family.

9031:TAF5L
gene id: 9031:TAF5L
uniprot id: E1C8E9
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9031:CD40
gene id: 9031:CD40
uniprot id: Q9DDD2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SNCG
gene id: 9031:SNCG
uniprot id: Q9I9H0
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

9031:TCIRG1
gene id: 9031:TCIRG1
uniprot id: Q9I8C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9031:LCMT1
gene id: 9031:LCMT1
uniprot id: Q5ZII2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9031:RPL4
gene id: 9031:RPL4
uniprot id: Q5ZII1
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9031:RAN
gene id: 9031:RAN
uniprot id: P42558
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Cytoplasm
messages: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis.
messages: Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.
messages: Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis. Interacts with KPNB1. Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity. Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP. Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP. Interacts (GTP-bound form) with TNPO1; the interaction is direct. Interacts (GTP-bound form) with TNPO3; the interaction is direct. Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity. Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity. Interacts with RANGRF, which promotes the release of bound guanine nucleotide. RANGRF and RCC1 compete for an overlapping binding site on RAN. Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex. Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1. Identified in a complex composed of RAN, RANGAP1 and RANBP1. Identified in a complex that contains TNPO1, RAN and RANBP1. Identified in a nuclear export complex with XPO1. Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1.
messages: Nucleus
messages: Nucleus envelope
messages: cytosol

9031:UFD1L
gene id: 9031:UFD1L
uniprot id: Q98UC3
names: Similarity
messages: Belongs to the UFD1 family.

9031:ST6GALNAC2
gene id: 9031:ST6GALNAC2
uniprot id: Q92184
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundantly expressed at all embryonic stages but not present in adult tissues.
messages: Belongs to the glycosyltransferase 29 family.
messages: Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed:8034663). Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage (PubMed:8034663).
messages: Golgi apparatus membrane
messages: Heart, kidney, testes, brain, liver and lung.

9031:CDH5
gene id: 9031:CDH5
uniprot id: Q8AYD0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.
messages: Cell junction
messages: Cell membrane
messages: N-glycosylated.
messages: O-glycosylated.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:CHMP6
gene id: 9031:CHMP6
uniprot id: Q5ZL55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endomembrane system
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).

9031:DCXR
gene id: 9031:DCXR
uniprot id: Q8JIS3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the reduction of D-erythrulose to D-threitol with the concomitant oxidation of NAD(P)H to NAD(P)(+). NADH is less effective than NADPH. May also catalyze the reduction of L-xylulose.
messages: Cytoplasm
messages: Highly expressed in kidney, and also found in high amounts in liver and testis. Low expression seen in all other tissues tested.
messages: Homotetramer.
messages: The N-terminus is blocked.

9031:VIPR1
gene id: 9031:VIPR1
uniprot id: A5A0U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9031:HIST1H46L6
gene id: 9031:HIST1H46L6
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:VCL
gene id: 9031:VCL
uniprot id: A0A8V0ZI80
uniprot id: P12003
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated; mainly by myristic acid but also by a small amount of palmitic acid.
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Exhibits self-association properties. Interacts with APBB1IP, NRAP and TLN1. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin.
messages: Exists in at least two conformations. When in the closed, 'inactive' conformation, extensive interactions between the head and tail domains prevent detectable binding to most of its ligands. It takes on an 'active' conformation after cooperative and simultaneous binding of two different ligands. This activation involves displacement of the head-tail interactions and leads to a significant accumulation of ternary complexes. The active form then binds a number of proteins that have both signaling and structural roles that are essential for cell adhesion.
messages: Isoform Metavinculin is muscle-specific.
messages: Membrane
messages: Phosphorylated; on serines, threonines and tyrosines. Phosphorylation on Tyr-1134 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques.
messages: The N-terminal globular head (Vh) comprises of subdomains D1-D4. The C-terminal tail (Vt) binds F-actin and cross-links actin filaments into bundles. An intramolecular interaction between Vh and Vt masks the F-actin-binding domain located in Vt. The binding of talin and alpha-actinin to the D1 subdomain of vinculin induces a helical bundle conversion of this subdomain, leading to the disruption of the intramolecular interaction and the exposure of the cryptic F-actin-binding domain of Vt. Vt inhibits actin filament barbed end elongation without affecting the critical concentration of actin assembly.
messages: adherens junction
messages: cytoskeleton
messages: focal adhesion
messages: podosome
messages: sarcolemma

9031:STX17
gene id: 9031:STX17
uniprot id: Q5ZKI5
names: Similarity
messages: Belongs to the syntaxin family.

9031:C6orf106
gene id: 9031:C6orf106
uniprot id: Q5F3N9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May have a roles as negative regulator of innate antiviral response.
messages: Nucleus

9031:CCSER1
gene id: 9031:CCSER1
uniprot id: A0A1D5PLD1
uniprot id: A0A8V0XU74
uniprot id: A0A8V0Y0H5
names: Similarity
messages: Belongs to the CCSER family.

9031:SNX14
gene id: 9031:SNX14
uniprot id: Q5ZIZ8
names: Similarity
messages: Belongs to the sorting nexin family.

9031:SASS6
gene id: 9031:SASS6
uniprot id: Q5ZMV2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity).
messages: Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets.
messages: The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
messages: centrosome

9031:NAB1
gene id: 9031:NAB1
uniprot id: Q8QG58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9031:NUP88
gene id: 9031:NUP88
uniprot id: A0A8V1AL56
names: Subcellular Location Annotation
messages: nuclear pore complex

9031:TNFRSF8
gene id: 9031:TNFRSF8
uniprot id: Q800I0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:THRAP3
gene id: 9031:THRAP3
uniprot id: F1NY54
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9031:DLX5
gene id: 9031:DLX5
uniprot id: P50577
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus
messages: Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA.

9031:TOB2
gene id: 9031:TOB2
uniprot id: Q5F453
names: Similarity
messages: Belongs to the BTG family.

9031:MAPKAPK3
gene id: 9031:MAPKAPK3
uniprot id: E1BT35
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:RDH5
gene id: 9031:RDH5
uniprot id: Q9DGM0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:ZC3H12A
gene id: 9031:ZC3H12A
uniprot id: A0A1D5P3N0
names: Similarity
messages: Belongs to the ZC3H12 family.

9031:FBXO18
gene id: 9031:FBXO18
uniprot id: F1ND48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17283053). Also promotes cell death and DNA double-strand breakage in response to replication stress: promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Chromosome
messages: Nucleus
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBH1) (By similarity).

9031:TCF15
gene id: 9031:TCF15
uniprot id: P79782
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes.
messages: First detected in a subpopulation of cells lateral to the primitive streak corresponding with the area of prospective segmental plate mesoderm and somites (PubMed:9187085, PubMed:9281340). Later in development, it is expressed throughout the segmental plate and newly formed somites and is restricted to the paraxial mesoderm (PubMed:9187085, PubMed:9281340). After somite formation, its expression decline in the lateral region of the somite (PubMed:9187085, PubMed:9281340). Later it is expressed at highest levels at the cranial and caudal edges of the more mature somites (PubMed:9187085, PubMed:9281340). As the dermomyotome and sclerotome formed, expression disappeared from the ventral regions of the somite, but persisted in the dermomyotome (PubMed:9187085, PubMed:9281340). When the dermomyotome developed further into the dermatome and myotome, expression is detected in both compartments, although more prominently in the dermatome (PubMed:9187085, PubMed:9281340). Expression was also detected in migrating precursors of tongue muscle and in the limb buds (PubMed:9187085, PubMed:9281340).
messages: Heterodimer; efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus
messages: Surface ectoderm and neural tube are the sources of inductive signals required for gene expression and for somite formation.

9031:ORMDL1
gene id: 9031:ORMDL1
uniprot id: A0A1D5PR34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9031:RPA1
gene id: 9031:RPA1
uniprot id: Q5ZJJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus
messages: PML body

9031:ACVR1C
gene id: 9031:ACVR1C
uniprot id: A0A3Q2TUT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9031:PPM1K
gene id: 9031:PPM1K
uniprot id: F1P138
names: Similarity
messages: Belongs to the PP2C family.

9031:PDSS2
gene id: 9031:PDSS2
uniprot id: E1C4Y7
uniprot id: U3M6H4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9031:ELOVL6
gene id: 9031:ELOVL6
uniprot id: E3VVZ9
uniprot id: Q5ZJR8
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The reaction is stimulated by the presence of HSD17B12, the enzyme catalyzing the second step of the elongation cycle.

9031:GPHN
gene id: 9031:GPHN
uniprot id: A0A8V0ZJ63
uniprot id: A0A8V0ZJ77
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9031:KCNK5
gene id: 9031:KCNK5
uniprot id: A0A8V0ZDH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9031:CYBB
gene id: 9031:CYBB
uniprot id: A7E3K8
names: Subcellular Location Annotation
messages: Membrane

9031:MAP3K14
gene id: 9031:MAP3K14
uniprot id: Q5F350
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9031:SRSF1
gene id: 9031:SRSF1
uniprot id: F1NQW8
uniprot id: Q5ZML3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Cytoplasm
messages: May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.
messages: Nucleus speckle

9031:ARHGEF11
gene id: 9031:ARHGEF11
uniprot id: A0A8V1ADE3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9031:MATN3
gene id: 9031:MATN3
uniprot id: O42401
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Can form homooligomers (monomers, dimers, trimers and tetramers) and heterooligomers with matrilin-1.
messages: Expression is restricted to cartilaginous tissues.
messages: Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
messages: Secreted

9031:MBTPS2
gene id: 9031:MBTPS2
uniprot id: A0A3Q2TYD2
uniprot id: E1BR82
names: Similarity
messages: Belongs to the peptidase M50A family.

9031:PIGK
gene id: 9031:PIGK
uniprot id: Q5F451
names: Similarity
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.

9031:BMPR2
gene id: 9031:BMPR2
uniprot id: O42124
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9031:LMX1B
gene id: 9031:LMX1B
uniprot id: P53413
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Specifies dorsal cell fate during limb development.

9031:CEBPB
gene id: 9031:CEBPB
uniprot id: Q05826
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Binds DNA as a dimer. Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (PubMed:20111005).
messages: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:8467792). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications.
messages: Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates the transcription of these genes.
messages: Methylated. Methylation at Arg-3 by CARM1 and at Lys-39 by EHMT2, inhibit transactivation activity. Methylation is probably inhibited by phosphorylation at Thr-220.
messages: Nucleus
messages: Specifically expressed in myelomoncytic cells.

9031:ADGRL4
gene id: 9031:ADGRL4
uniprot id: A0A8V0ZRI6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:MRPL28
gene id: 9031:MRPL28
uniprot id: F6UK13
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

9031:NOX3
gene id: 9031:NOX3
uniprot id: A0A8V0XN18
names: Subcellular Location Annotation
messages: Membrane

9031:MANEAL
gene id: 9031:MANEAL
uniprot id: E1BYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:USP10
gene id: 9031:USP10
uniprot id: Q5ZJN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels. Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
messages: Nucleus

9031:NRP1
gene id: 9031:NRP1
uniprot id: A0A8V0XQ20
uniprot id: P79795
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neuropilin family.
messages: Cell membrane
messages: Developing nervous system; optic tectum (layers D and E of SGFS), amacrine cells of retina, neurites of dorsal root ganglia. Also expressed in non-neuronal cells, e.g. blood vessels in the entire embryo.
messages: Homodimer, and heterodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion membrane
messages: Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction (By similarity).

9031:CARS
gene id: 9031:CARS
uniprot id: Q5F408
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
messages: Cytoplasm
messages: Homodimer.

9031:COL4A3BP
gene id: 9031:COL4A3BP
uniprot id: A0A8V0Y7K8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

9031:VEGFA
gene id: 9031:VEGFA
uniprot id: P67964
uniprot id: Q540I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity).

9031:P4HA2
gene id: 9031:P4HA2
uniprot id: Q5ZLK5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P4HA family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen
messages: Heterotetramer of two alpha-2 chains and two beta chains (the beta chain is the multi-functional PDI).

9031:SEC23B
gene id: 9031:SEC23B
uniprot id: Q5ZK03
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.
messages: Endoplasmic reticulum membrane
messages: The Gelsolin-like repeat mediates interaction with proteins containing PPP motifs.
messages: cytosol

9031:FAM92A
gene id: 9031:FAM92A
uniprot id: A0A8V0YG70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole

9031:GNA11
gene id: 9031:GNA11
uniprot id: Q71RI7
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9031:ISY1
gene id: 9031:ISY1
uniprot id: F1P220
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9031:DRD4
gene id: 9031:DRD4
uniprot id: B6UVA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:GSG1L
gene id: 9031:GSG1L
uniprot id: E1BSG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9031:MAP2
gene id: 9031:MAP2
uniprot id: A0A3Q2U4G6
names: Subcellular Location Annotation
messages: cytoskeleton

9031:ADRA1A
gene id: 9031:ADRA1A
uniprot id: F1NP52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9031:INSRR
gene id: 9031:INSRR
uniprot id: H9KZZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9031:OGN
gene id: 9031:OGN
uniprot id: Q9W6H0
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Contains keratan sulfate.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: Levels decrease at each developmental time point and further decrease during maturation into adulthood.
messages: The composition of the N-linked chains or the substitution of the N-linked sites is different between embryonic and adult tissues.
messages: extracellular matrix

9031:FUT8
gene id: 9031:FUT8
uniprot id: Q659W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9031:LDB2
gene id: 9031:LDB2
uniprot id: Q9W676
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the LDB family.
messages: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.
messages: First expressed at stages 15-16 in presumptive limb mesoderm. As limb outgrowth proceeds, expressed in the entire limb bud, concentrating in the distal mesoderm throughout limb development. Both hindlimbs and forelimbs exhibit similar expression patterns.
messages: Lacks LIM-binding domain.
messages: Nucleus

9031:IREB2
gene id: 9031:IREB2
uniprot id: Q5ZLQ4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit. [4Fe-4S]-binding affects RNA-binding activity, thereby inhibiting activity of the protein.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
messages: Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen.

9031:MED30
gene id: 9031:MED30
uniprot id: A0A1D5NUC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9031:SLC17A5
gene id: 9031:SLC17A5
uniprot id: A0A3Q2U392
uniprot id: Q5ZL94
names: Subcellular Location Annotation
messages: Membrane

9031:PLN
gene id: 9031:PLN
uniprot id: P26677
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Heart.
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Phosphorylated in response to beta-adrenergic stimulation. Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake (By similarity).
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity).
messages: Sarcoplasmic reticulum membrane

9031:TMEM11
gene id: 9031:TMEM11
uniprot id: Q5ZLD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

9031:NTM
gene id: 9031:NTM
uniprot id: Q90773
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. IgLON family.
messages: Cell membrane
messages: Expressed by developing cerebellar Purkinje cells. Expression coincides with the growth of the dendritic tree, after Purkinje cells have finished their migration from the ventricular zone (from 15 dpc until 21 dpc). Expressed in the adult.
messages: Found on the dendrites, somata and axons of developing Purkinje cells. Undetectable on other neurons like Golgi or granule cells.
messages: Interacts with NEGR1.
messages: It may be a cellular address molecule specific to Purkinje cells. It may represent a receptor or a subunit of a receptor complex.

9031:SLC35E3
gene id: 9031:SLC35E3
uniprot id: F1NGX8
names: Subcellular Location Annotation
messages: Membrane

9031:MSMP
gene id: 9031:MSMP
uniprot id: A0A8V0Y2Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9031:SPTBN1
gene id: 9031:SPTBN1
uniprot id: A0A1D5P797
uniprot id: A0A1D5PJY1
names: Similarity
messages: Belongs to the spectrin family.

9031:CASP7
gene id: 9031:CASP7
uniprot id: F1NV61
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cleavage by different proteases, such as granzyme B (GZMB), caspase-1 (CASP1), caspase-8 (CASP8) or caspase-9 (CASP9) generate the two active subunits. Its involvement in different programmed cell death processes is probably specified by the protease that activates CASP7 (By similarity). Cleaved and activated by initiator caspases (CASP8 and/or CASP9), leading to execution phase of apoptosis (By similarity). Cleavage and maturation by GZMB regulates granzyme-mediated programmed cell death (By similarity). Cleaved and activated by CASP1 in response to bacterial infection (By similarity).
messages: During activation, the N-terminal disordered prodomain is removed by cleavage. Concomitantly, double cleavage gives rise to a large Caspase-7 subunit p20 and a small Caspase-7 subunit p11. The two large and two small subunits then assemble to form the active CASP7 complex. Can be cleaved and activated by different caspases, depending on the context (By similarity). Cleaved and activated by initiator caspases (CASP8 and/or CASP9), leading to execution phase of apoptosis (By similarity). Cleavage and maturation by GZMB regulates granzyme-mediated programmed cell death. Cleavage and maturation by CASP1 regulates pyroptosis (By similarity).
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.
messages: Nucleus
messages: Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:14583630). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (By similarity). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8 and/or CASP9), mediates execution of apoptosis by catalyzing cleavage of proteins (PubMed:14583630). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (By similarity). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (By similarity).
messages: cytosol
messages: extracellular space

9031:SSX2IP
gene id: 9031:SSX2IP
uniprot id: E1BU32
uniprot id: Q1L1D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

9031:STUB1
gene id: 9031:STUB1
uniprot id: Q5ZHY5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (By similarity). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity).
messages: Homodimer.
messages: The U-box domain is required for the ubiquitin protein ligase activity.

9031:PRPF19
gene id: 9031:PRPF19
uniprot id: Q5ZMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Cytoplasm
messages: Homotetramer. Component of activated, catalytic and post-catalytic spliceosomes. Component of the NTC complex (or PRP19-associated complex) which is associated with the spliceosome. Interacts with KHDC4 (By similarity).
messages: Lipid droplet
messages: Nucleus
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity.
messages: nucleoplasm
messages: spindle

9031:SDC2
gene id: 9031:SDC2
uniprot id: Q8JIX9
uniprot id: Q8JIY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9031:TGFBR2
gene id: 9031:TGFBR2
uniprot id: A0A1I7Q417
uniprot id: Q90999
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Detected at low levels in embryonic heart, brain and lung. Detected at high levels in hatchling heart and lung.
messages: Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer.
messages: Membrane
messages: Membrane raft
messages: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).

9031:FAM199X
gene id: 9031:FAM199X
uniprot id: F1NN36
names: Similarity
messages: Belongs to the FAM199 family.

9031:PFKFB2
gene id: 9031:PFKFB2
uniprot id: A0A8V1AG88
uniprot id: A0A8V1AI32
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9031:NHSL2
gene id: 9031:NHSL2
uniprot id: A0A8V0YRI4
uniprot id: A0A8V0YRJ0
uniprot id: A0A8V0YRM5
uniprot id: R4GFL3
names: Similarity
messages: Belongs to the NHS family.

9031:PNN
gene id: 9031:PNN
uniprot id: E1C2F2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

9031:HIST1H3H
gene id: 9031:HIST1H3H
uniprot id: P84229
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

9031:RPE65
gene id: 9031:RPE65
uniprot id: Q9YGX2
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cell membrane
messages: Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:19490105). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (By similarity). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).
messages: Cytoplasm
messages: Highly expressed in the retinal pigment epithelium (RPE)/ choroid of the 21 dpc embryos (at protein level).
messages: Microsome membrane
messages: Palmitoylation by LRAT regulates ligand binding specificity; the palmitoylated form (membrane form) specifically binds all-trans-retinyl-palmitate, while the soluble unpalmitoylated form binds all-trans-retinol (vitamin A).
messages: Retinal pigment epithelium specific.

9031:ERI1
gene id: 9031:ERI1
uniprot id: Q5ZL01
names: Subcellular Location Annotation
messages: Cytoplasm

9031:CYB5A
gene id: 9031:CYB5A
uniprot id: P00174
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:RPIA
gene id: 9031:RPIA
uniprot id: Q5ZI35
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9031:ANXA11
gene id: 9031:ANXA11
uniprot id: A0A1D5PN32
uniprot id: Q5ZLG6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9031:ACO1
gene id: 9031:ACO1
uniprot id: Q90875
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: cytosol

9031:C1orf174
gene id: 9031:C1orf174
uniprot id: F1P3V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9031:PRPSAP2
gene id: 9031:PRPSAP2
uniprot id: Q5ZL26
names: Function
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.

9031:APOD
gene id: 9031:APOD
uniprot id: Q5G8Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9031:HOXD4
gene id: 9031:HOXD4
uniprot id: F1NZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9031:KRT7
gene id: 9031:KRT7
uniprot id: A0A146F0A0
uniprot id: O93532
names: Developmental Stage
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Abundant in the cochlea of the inner ear, where it is found in the cells of the tegmentum vasculosum. Lower levels also found in the heart and forebrain.
messages: Belongs to the intermediate filament family.
messages: Heterotetramer of two type I and two type II keratins.
messages: Specifically expressed at the late developmental stages in the cochlea.

9031:IL13RA2
gene id: 9031:IL13RA2
uniprot id: Q0KKP6
names: Subcellular Location Annotation
messages: Membrane

9031:TBX4
gene id: 9031:TBX4
uniprot id: O93288
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:GPM6A
gene id: 9031:GPM6A
uniprot id: Q5EES3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9031:REV1
gene id: 9031:REV1
uniprot id: Q4KWZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion.
messages: Monomer.
messages: Nucleus
messages: The C-terminal domain is necessary for protein interactions.

9031:SPCS3
gene id: 9031:SPCS3
uniprot id: P28687
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SPCS3 family.
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:2831945). Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:2831945). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).
messages: Expressed in hen oviduct (at protein level).

9031:ARPP19
gene id: 9031:ARPP19
uniprot id: Q5ZLY8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Interacts (when phosphorylated at Ser-62) with PPP2R2D.
messages: Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A.
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).

9031:SHH
gene id: 9031:SHH
uniprot id: Q91035
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the hedgehog family.
messages: Binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain.
messages: By retinoic acid.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed in the posterior limb bud mesenchyme, the Hensen node, the notochord, and the floor plate of the neural tube.
messages: First detectable at stage 17 during the initiation of limb bud formation. From that point onwards, the expression pattern exactly matches the location of the zone of polarizing activity (ZPA).
messages: Golgi apparatus membrane
messages: Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus (By similarity). Interacts with BOC and CDON (By similarity). Interacts with HHIP (By similarity). Interacts with DISP1 via its cholesterol anchor (By similarity). Interacts with SCUBE2 (By similarity).
messages: Multimer.
messages: N-palmitoylation by HHAT of ShhN is required for sonic hedgehog protein N-product multimerization and full activity (By similarity). It is a prerequisite for the membrane-proximal positioning and the subsequent shedding of this N-terminal peptide (By similarity).
messages: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (ShhN) (By similarity). Cholesterylation is required for the sonic hedgehog protein N-product targeting to lipid rafts and multimerization (By similarity). ShhN is the active species in both local and long-range signaling, whereas the C-product (ShhC) is degraded in the reticulum endoplasmic (By similarity).
messages: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).
messages: The Cardin-Weintraub (CW) motif is required for heparan sulfate binding of the solubilized ShhNp (By similarity). The N-terminal palmitoylated peptide is cleaved at the Heparan sulfate-binding Cardin-Weintraub (CW) motif site (By similarity). The cleavage reduced the interactions with heparan sulfate. The cleavage is enhanced by SCUBE2 (By similarity).
messages: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed:7736596). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (By similarity).
messages: The lipidated N- and C-terminal peptides of ShhNp can be cleaved (shedding) (By similarity). The N-terminal palmitoylated peptide is cleaved at the Cardin-Weintraub (CW) motif site (By similarity). The cleavage reduced the interactions with heparan sulfate (By similarity). The cleavage is enhanced by SCUBE2 (By similarity).
messages: The several steps and mechanisms that permit controlled Shh dispersion and gradient formation remain controversial. The ShhNC C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity resulting in the cleavage and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (ShhN). The protein is further modified by covalent addition of palmitate at the N-terminal of ShhN, resulting to the dual-lipidated Shh (ShhNp). ShhNp is firmly tethered to the cell membrane where it forms multimers. Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by proteolytic removal of both terminal lipidated peptides. Once released, the fully processed Shh can signal within embryonic tissues both at short and long-range.

9031:ABCC5
gene id: 9031:ABCC5
uniprot id: A0A8V0Z5L8
names: Subcellular Location Annotation
messages: Membrane

9031:AvBD6
gene id: 9031:AvBD6
uniprot id: Q6QLR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Expressed in bone marrow, testis, ovary, lung and trachea. Expressed in the ovarian stroma, but not in the ovarian follicles.
messages: Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis.
messages: Secreted

9031:SPTY2D1
gene id: 9031:SPTY2D1
uniprot id: E1BUG7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT2 family.
messages: Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro) (By similarity). Modulates RNA polymerase 1-mediated transcription (PubMed:23378026). Required for optimal growth in the presence of the DNA damaging agents actinomycin D or mitomycin C (in vitro) (PubMed:23378026). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity).
messages: Interacts with POLR1A (Probable) (PubMed:23378026). Interacts with histones (PubMed:23378026). Interacts with a heterotetrameric complex formed by histone H3 and H4, especially when the histone tetramer is not bound to DNA (By similarity).
messages: The acidic C-terminal domain mediates interaction with histone H3/H4 complexes.
messages: nucleolus

9031:ILKAP
gene id: 9031:ILKAP
uniprot id: E1BYA9
names: Similarity
messages: Belongs to the PP2C family.

9031:NTSR1
gene id: 9031:NTSR1
uniprot id: E7FKE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:DLG1
gene id: 9031:DLG1
uniprot id: A0A1D5PT29
uniprot id: A0A3Q2TXA3
uniprot id: A0A8V0Z7R0
uniprot id: E1BT38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9031:KIZ
gene id: 9031:KIZ
uniprot id: Q5ZK13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

9031:AMY2A
gene id: 9031:AMY2A
uniprot id: Q98942
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9031:TAGLN3
gene id: 9031:TAGLN3
uniprot id: E1C7W7
names: Similarity
messages: Belongs to the calponin family.

9031:TAF7
gene id: 9031:TAF7
uniprot id: F1NI87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9031:FERMT2
gene id: 9031:FERMT2
uniprot id: A0A1D5PU09
names: Similarity
messages: Belongs to the kindlin family.

9031:RDX
gene id: 9031:RDX
uniprot id: Q9PU45
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
messages: cytoskeleton

9031:EIF3F
gene id: 9031:EIF3F
uniprot id: A0A8V0ZBR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

9031:LY6E
gene id: 9031:LY6E
uniprot id: Q90986
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed by thymic blast cells.

9031:VPS26B
gene id: 9031:VPS26B
uniprot id: F1NPH4
names: Similarity
messages: Belongs to the VPS26 family.

9031:CIR1
gene id: 9031:CIR1
uniprot id: Q5ZI03
names: Function
names: Subcellular Location Annotation
messages: May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor. Recruits repressors to the histone deacetylase complex (HDAC) (By similarity).
messages: Nucleus speckle

9031:FGF14
gene id: 9031:FGF14
uniprot id: A0A3Q3A899
uniprot id: Q9IAI5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:ACVR2A
gene id: 9031:ACVR2A
uniprot id: A0A8V0Y294
uniprot id: Q90669
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG).
messages: Expressed in hen anterior pituitary during the ovulatory cycle and in the ovarian follicle.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.

9031:MT4
gene id: 9031:MT4
uniprot id: P68497
names: Domain
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9031:CDC45
gene id: 9031:CDC45
uniprot id: A0A3Q2UBE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9031:SCRN1
gene id: 9031:SCRN1
uniprot id: F1N8X7
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9031:TPD52L1
gene id: 9031:TPD52L1
uniprot id: A0A8V0XNW1
uniprot id: Q9I8F4
names: Similarity
names: Subunit
messages: Belongs to the TPD52 family.
messages: Forms a homodimer or heterodimer with other members of the family.

9031:BLOC1S2
gene id: 9031:BLOC1S2
uniprot id: A0A1L1RL19
names: Similarity
messages: Belongs to the BLOC1S2 family.

9031:NXT2
gene id: 9031:NXT2
uniprot id: Q5ZLH0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with NXF1, NXF2, NXF3 and NXF5.
messages: Cytoplasm
messages: Nucleus
messages: Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity).

9031:RGS3
gene id: 9031:RGS3
uniprot id: Q7SYH9
names: Subcellular Location Annotation
messages: Cytoplasm

9031:SELENOT
gene id: 9031:SELENOT
uniprot id: Q5ZJN8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelWTH family. Selenoprotein T subfamily.
messages: Endoplasmic reticulum membrane
messages: May contain a selenide-sulfide bond between Cys-50 and Sec-53. This bond is speculated to serve as redox-active pair (By similarity).
messages: Selenoprotein with thioredoxin reductase-like oxidoreductase activity.

9031:LPAR3
gene id: 9031:LPAR3
uniprot id: B0FMV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:THOC5
gene id: 9031:THOC5
uniprot id: Q5ZJK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).
messages: Belongs to the THOC5 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.
messages: Cytoplasm
messages: May be involved in cell differentiation.
messages: Nucleus

9031:P3H2
gene id: 9031:P3H2
uniprot id: Q6JHU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leprecan family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (By similarity). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity).
messages: Sarcoplasmic reticulum

9031:PDGFD
gene id: 9031:PDGFD
uniprot id: A0A3Q2U6E1
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PCDHAC2
gene id: 9031:PCDHAC2
uniprot id: Q6R0H8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9031:PPIL1
gene id: 9031:PPIL1
uniprot id: A0A1D5PW44
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9031:CNOT9
gene id: 9031:CNOT9
uniprot id: A0A1D5PVC4
uniprot id: A0A8V0ZJK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9031:MRPS16
gene id: 9031:MRPS16
uniprot id: E1C907
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9031:TMOD3
gene id: 9031:TMOD3
uniprot id: Q5ZLY3
names: Subcellular Location Annotation
messages: cytoskeleton

9031:CD79B
gene id: 9031:CD79B
uniprot id: Q5ZLC0
uniprot id: Q8AV16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:NPM1
gene id: 9031:NPM1
uniprot id: P16039
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA (By similarity).
messages: Belongs to the nucleoplasmin family.
messages: Cytoplasm
messages: Decamer formed by two pentameric rings associated in a head-to-head fashion.
messages: Phosphorylated.
messages: nucleolus
messages: nucleoplasm

9031:GDPD4
gene id: 9031:GDPD4
uniprot id: F1NRU6
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:EIF1
gene id: 9031:EIF1
uniprot id: P51971
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SUI1 family.
messages: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. Together with eIF1A (EIF1AX), EIF1 facilitates scanning and is essential for start codon recognition on the basis of AUG nucleotide context and location relative to the 5'-cap. Participates to initiation codon selection by influencing the conformation of the 40S ribosomal subunit and the positions of bound mRNA and initiator tRNA; this is possible after its binding to the interface surface of the platform of the 40S ribosomal subunit close to the P-site. Together with eIF1A (EIF1AX), also regulates the opening and closing of the mRNA binding channel, which ensures mRNA recruitment, scanning and the fidelity of initiation codon selection. Continuously monitors and protects against premature and partial base-pairing of codons in the 5'-UTR with the anticodon of initiator tRNA. Together with eIF1A (EIF1AX), acts for ribosomal scanning, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. Interacts with EIF4G1, which in a mutual exclusive interaction associates either with EIF1 or with EIF4E on a common binding site. EIF4G1-EIF1 complex promotes ribosome scanning (on both short and long 5'UTR), leaky scanning (on short 5'UTR) which is the bypass of the initial start codon, and discrimination against cap-proximal AUG. Is probably maintained within the 43S PIC in open conformation thanks to eIF1A-EIF5 interaction. Once the correct start codon is reached, EIF1 is physically excluded from the decoding site, shifting the PIC into the closed conformation and arresting it at the start codon.
messages: Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with EIF4G1; in specific 5'-UTR length and AUG context. Interacts with EIF5; which in a mutual exclusive interaction associates either with EIF1 or with EIF2S2 on a common binding site. Interacts with RENT2.
messages: Cytoplasm

9031:TFDP2
gene id: 9031:TFDP2
uniprot id: A0A3Q2U996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9031:SYNJ1
gene id: 9031:SYNJ1
uniprot id: A0A8V0Y130
uniprot id: A0A8V0Y5M7
uniprot id: A0A8V0Y798
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9031:GNAI2
gene id: 9031:GNAI2
uniprot id: P50147
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division (By similarity).
messages: centrosome

9031:ATP1B4
gene id: 9031:ATP1B4
uniprot id: Q2HZ96
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Composed of two subunits: alpha (catalytic) and beta (accessory).
messages: Expressed in embryo in skeletal muscle, heart, brain, retina, inner ear and skin at 19 dpc.
messages: Expressed in skeletal muscle, intestine, heart, brain, retina, inner ear and skin.
messages: Glycosylated.
messages: Its function as a Na,K-ATPase beta-subunit will be lost in placental mammals.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9031:DYM
gene id: 9031:DYM
uniprot id: A0A3Q3ASW2
uniprot id: Q5ZLW3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dymeclin family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment.
messages: Necessary for correct organization of Golgi apparatus.

9031:BNIP3
gene id: 9031:BNIP3
uniprot id: A0A8V0X877
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9031:NUCB2
gene id: 9031:NUCB2
uniprot id: A0A8V0ZSE1
uniprot id: Q5ZHR1
names: Similarity
messages: Belongs to the nucleobindin family.

9031:NFIB
gene id: 9031:NFIB
uniprot id: P17924
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9031:RPL37
gene id: 9031:RPL37
uniprot id: E1C810
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9031:KIF3A
gene id: 9031:KIF3A
uniprot id: A0A8V0YVT3
uniprot id: Q5F3C2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:IGF2
gene id: 9031:IGF2
uniprot id: P33717
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.

9031:VAMP3
gene id: 9031:VAMP3
uniprot id: F1P4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9031:TMEM55A
gene id: 9031:TMEM55A
uniprot id: A0A1D5PD65
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9031:SLC9A1
gene id: 9031:SLC9A1
uniprot id: Q1PS52
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9031:ETF1
gene id: 9031:ETF1
uniprot id: A0A1L1RX26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9031:PTP4A2
gene id: 9031:PTP4A2
uniprot id: A0A1D5PVR6
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9031:WIF1
gene id: 9031:WIF1
uniprot id: A0A1D5PHP9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:NFIX
gene id: 9031:NFIX
uniprot id: Q90932
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9031:MSGN1
gene id: 9031:MSGN1
uniprot id: Q9DEQ9
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in the presomitic mesoderm preceding the formation of somites. At stage 4 expressed in and around the primitive streak. During subsequent development, expression domain persists, and gradually retracts in parallel to the retracting Hensen's node towards the caudal end. Expression begins to accumulate in gastrulating mesoderm and is later restricted to paraxial mesoderm, prior to the onset of somite formation. No expression is seen within somites, nor in the tailbud mesoderm.
messages: Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).
messages: Nucleus

9031:NGF
gene id: 9031:NGF
uniprot id: A0A140T8F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted

9031:ANKRD44
gene id: 9031:ANKRD44
uniprot id: Q5F478
names: Function
names: Subunit
messages: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).
messages: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

9031:MTTP
gene id: 9031:MTTP
uniprot id: M9QWS9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:LCAT
gene id: 9031:LCAT
uniprot id: P53760
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: APOA1 is the most potent activator in plasma. Also activated by APOE, APOC1 and APOA4 (By similarity).
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107).
messages: Detected in blood plasma (at protein level) (PubMed:7592817, PubMed:8820107). Expressed in liver, brain and adrenal glands. Lower expression in testes. In laying hens, expressed higher in brain than in liver. In roosters, higher levels in liver than in brain (PubMed:7592817).
messages: Expressed in liver during embryogenesis. Levels higher in liver than in brain up to 15 weeks after hatching. In the brain, first detected at 11 weeks after hatching and increasing levels from 15 weeks to maturity (25 weeks). Expression in the liver is much lower throughout these later stages of hatching.
messages: Secreted

9031:LOC107057555
gene id: 9031:LOC107057555
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:CHRNA1
gene id: 9031:CHRNA1
uniprot id: P09479
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
messages: Cell membrane
messages: One of the alpha chains that assemble within the acetylcholine receptor, a pentamer of two alpha chains, a beta, a delta, and a gamma or epsilon chains.
messages: Postsynaptic cell membrane
messages: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

9031:COPB1
gene id: 9031:COPB1
uniprot id: Q5ZIA5
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Expressed more highly in male embryonic day 3 (3 dpc) and 5 dpc whole embryos, paired urogenital system at 7 dpc and gonads at 9 dpc than in females.
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

9031:ZP3
gene id: 9031:ZP3
uniprot id: P79762
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, which mediates species-specific sperm binding. Directly binds to sperm. Important for egg fertilization.
messages: Detected in the ovarian perivitteline layer. Detected in granulosa cells in ovarian follicle (at protein level). Detected in granulosa cells in ovarian follicle.
messages: Homodimer. Forms higher oligomers, once its C-terminus has been proteolytically removed. Forms heterooligomers with other zona pellucida glycoproteins (By similarity).
messages: N-glycosylated.
messages: O-glycosylated. O-glycosylation at Thr-168 is important for efficient interaction with the sperm head.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: extracellular matrix

9031:AFAP1
gene id: 9031:AFAP1
uniprot id: Q90738
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Functions as an adapter molecule that links other proteins to the actin cytoskeleton. May function in facilitating interactions between SRC and actin filaments. May modulate changes in actin filament integrity and induce lamellipodia formation. Can cross-link actin filaments into both network and bundle structures.
messages: Isoform 2 is specifically expressed in brain.
messages: Monomer and homomultimer. Interacts via its C-terminus with F-actin; probably involving AFAP1 multimers. Interacts with activated SRC SH3-SH2 domains. May interact with FYN SH3-SH2 domains. Interacts via its PH 1 domain with PRKCA, PRKCB, PRKCI.
messages: Phosphorylated on tyrosine residues by SRC.
messages: stress fiber

9031:NKAPL
gene id: 9031:NKAPL
uniprot id: Q5ZIJ3
names: Similarity
messages: Belongs to the NKAP family.

9031:SERINC3
gene id: 9031:SERINC3
uniprot id: Q5ZJ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9031:GRPEL1
gene id: 9031:GRPEL1
uniprot id: Q5ZHV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9031:SSTR5
gene id: 9031:SSTR5
uniprot id: Q58G83
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:TMEM47
gene id: 9031:TMEM47
uniprot id: R4GIT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9031:DESI1
gene id: 9031:DESI1
uniprot id: A0A3Q3B0Z9
names: Similarity
messages: Belongs to the DeSI family.

9031:SH3GL3
gene id: 9031:SH3GL3
uniprot id: Q8AXU9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Early endosome membrane
messages: Expressed in early stages of follicle development up to large white follicles with highest level in small white follicles.
messages: Hens express reduced levels of SH3GL3 in ovarian follicles prior to uptake of yolk proteins.
messages: Highest level in a region associated with endocytosis of yolk proteins in developing oocytes (at protein level). Highest level in small ovarian follicles. High levels in brain and testis. Lower level in adrenal glands.
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Implicated in endocytosis of yolk proteins during oogenesis.
messages: Interacts with ARC (By similarity). Interacts with SYNJ1 and DNM1.

9031:PMPCA
gene id: 9031:PMPCA
uniprot id: Q5ZJ49
names: Similarity
messages: Belongs to the peptidase M16 family.

9031:WDFY1
gene id: 9031:WDFY1
uniprot id: Q5ZI38
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9031:KCNH8
gene id: 9031:KCNH8
uniprot id: F1P320
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9031:IL6
gene id: 9031:IL6
uniprot id: D9ZYR9
uniprot id: Q90YI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: Secreted

9031:FGF16
gene id: 9031:FGF16
uniprot id: Q197G3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:ARL1
gene id: 9031:ARL1
uniprot id: E1BVB0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9031:E2F4
gene id: 9031:E2F4
uniprot id: Q5ZJU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9031:AUH
gene id: 9031:AUH
uniprot id: A0A3Q2U419
uniprot id: E1BTQ9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9031:SSPO
gene id: 9031:SSPO
uniprot id: Q2PC93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thrombospondin family.
messages: Involved in the modulation of neuronal aggregation (By similarity). May be involved in developmental events during the formation of the central nervous system (By similarity).
messages: extracellular space

9031:TWF2
gene id: 9031:TWF2
uniprot id: Q5ZM35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin (By similarity).
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: Interacts with G-actin; ADP-actin form and capping protein (CP).
messages: cytoskeleton
messages: perinuclear region

9031:HMX3
gene id: 9031:HMX3
uniprot id: O57601
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMX homeobox family.
messages: Expressed in the otic placode beginning at stage 10 and exhibits a dynamic expression pattern during formation and further differentiation of the otic vesicle.
messages: Nucleus
messages: Regulated by DAN in inner ear.
messages: Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity).

9031:TMEM86A
gene id: 9031:TMEM86A
uniprot id: A0A3Q2U4R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9031:MINPP1
gene id: 9031:MINPP1
uniprot id: F1NPQ2
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (PubMed:9472008). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). May play a role in bone development (endochondral ossification) (By similarity). May play a role in the transition of chondrocytes from proliferation to hypertrophy (PubMed:8660956, PubMed:9472008).
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.
messages: Endoplasmic reticulum lumen
messages: Monogastric animals cannot hydrolyze dietary inositol hexakisphosphate (InsP6) which makes up the bulk of organic phosphates in soybean, grains and other plant seeds which are the primary source of animal feed. The high activity of the chicken protein toward InsP6 offers a genetic strategy for improving InsP6 digestion in poultry and reducing the pollution that results from high phosphate content in manure.
messages: N-glycosylated.
messages: Present in growth plate chondrocytes but not detectable in articular chondrocytes (at protein level) (PubMed:9472008). Spatially restricted to chondrocytes in the lower portion of the proliferative zone and the upper portion of the hypertrophic zone in the growth plate of long bones (at protein level) (PubMed:9472008). Weakly expressed in kidney, liver, lung, skin and spleen, and not detected in brain, heart and muscle (PubMed:8660956).
messages: Repressed by parathyroid hormone-related protein PTHLH/PTHRP.

9031:TAF15
gene id: 9031:TAF15
uniprot id: E1BT66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9031:PDGFB
gene id: 9031:PDGFB
uniprot id: Q90W23
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9031:SLC25A16
gene id: 9031:SLC25A16
uniprot id: A0A8V0ZR95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:BAP1
gene id: 9031:BAP1
uniprot id: Q5F3N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family. BAP1 subfamily.
messages: Component of the PR-DUB complex.
messages: Cytoplasm
messages: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity).
messages: Nucleus

9031:MIEF1
gene id: 9031:MIEF1
uniprot id: E1BVG4
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9031:CRPL1
gene id: 9031:CRPL1
uniprot id: Q2EJU6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9031:FZD6
gene id: 9031:FZD6
uniprot id: A0A8V0Y788
uniprot id: Q6WJ02
uniprot id: Q9PTW1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, may be involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).
messages: The FZ domain is involved in binding with Wnt ligands.

9031:NCOA1
gene id: 9031:NCOA1
uniprot id: A0A8V0YAE0
uniprot id: Q5F393
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9031:ASS1
gene id: 9031:ASS1
uniprot id: Q5ZJ23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family.
messages: Homotetramer.
messages: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
messages: cytosol

9031:OTP
gene id: 9031:OTP
uniprot id: R4GH47
names: Subcellular Location Annotation
messages: Nucleus

9031:CSGALNACT2
gene id: 9031:CSGALNACT2
uniprot id: E1C2T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9031:ATG16L2
gene id: 9031:ATG16L2
uniprot id: A0A8V0ZYB6
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9031:PCDHA1
gene id: 9031:PCDHA1
uniprot id: Q6R0J0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:CMTM7
gene id: 9031:CMTM7
uniprot id: Q5ZLJ3
names: Subcellular Location Annotation
messages: Membrane

9031:MT3
gene id: 9031:MT3
uniprot id: A4PBT0
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9031:TIMM44
gene id: 9031:TIMM44
uniprot id: F1NU71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

9031:GABRG2
gene id: 9031:GABRG2
uniprot id: A0A8V0XYY9
uniprot id: P21548
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by benzodiazepines (By similarity). Activated by pentobarbitol (By similarity). Inhibited by the antagonist bicuculline (By similarity). Inhibited by zinc ions (By similarity).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The extracellular domain contributes to synaptic contact formation.
messages: This subunit carries the benzodiazepine binding site.

9031:CDX2
gene id: 9031:CDX2
uniprot id: P79788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9031:ABCC4
gene id: 9031:ABCC4
uniprot id: Q5ZMK2
names: Subcellular Location Annotation
messages: Membrane

9031:TAGLN
gene id: 9031:TAGLN
uniprot id: P19966
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Actin cross-linking/gelling protein.
messages: Belongs to the calponin family.
messages: Cytoplasm
messages: Gizzard, uterus, intestine, esophagus, aorta, and trace amounts in brain, liver and heart.
messages: Monomer.

9031:CENPU
gene id: 9031:CENPU
uniprot id: Q2Z1W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-U/AME1 family.
messages: Interacts with CENPH-CENPI complex at the kinetochore.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for maintenance of sister chromatid adhesion during mitotic checkpoint activation.
messages: centromere

9031:TOR1AIP1
gene id: 9031:TOR1AIP1
uniprot id: A0A8V0Y6Y7
uniprot id: A0A8V0Y6Z2
uniprot id: A0A8V0YFE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9031:PAK1IP1
gene id: 9031:PAK1IP1
uniprot id: Q5ZKU8
names: Function
names: Subcellular Location Annotation
messages: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
messages: nucleolus

9031:PSMD9
gene id: 9031:PSMD9
uniprot id: Q5ZJS1
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9031:ACACA
gene id: 9031:ACACA
uniprot id: P11029
names: Activity Regulation
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 2 manganese ions per subunit.
messages: By phosphorylation.
messages: Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
messages: Cytoplasm

9031:LHX8
gene id: 9031:LHX8
uniprot id: F1P4G9
names: Subcellular Location Annotation
messages: Nucleus

9031:LGR4
gene id: 9031:LGR4
uniprot id: A0A1D5PB24
names: Subcellular Location Annotation
messages: Membrane

9031:MCTS1
gene id: 9031:MCTS1
uniprot id: Q5ZI42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm
messages: Plays a role as translation enhancer and involved in cell cycle regulation.
messages: The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function.

9031:CLK4
gene id: 9031:CLK4
uniprot id: E1C4D8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:MED9
gene id: 9031:MED9
uniprot id: A0A8V0Z2U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:BCAP29
gene id: 9031:BCAP29
uniprot id: E1C310
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9031:ATP8B4
gene id: 9031:ATP8B4
uniprot id: E1BVN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:TYR
gene id: 9031:TYR
uniprot id: A0A411DFI8
uniprot id: P55024
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Binds 2 copper ions per subunit.
messages: Melanosome
messages: Melanosome membrane
messages: Membrane
messages: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity).

9031:ARL6
gene id: 9031:ARL6
uniprot id: A0A1D5PWK2
uniprot id: A0A1L1RMR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9031:SFRP1
gene id: 9031:SFRP1
uniprot id: A0A1L1RQ37
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ARPC3
gene id: 9031:ARPC3
uniprot id: E1C8Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9031:SEPTIN6
gene id: 9031:SEPTIN6
uniprot id: A0A8V0YP91
uniprot id: Q5ZM42
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9031:ORC5
gene id: 9031:ORC5
uniprot id: A0A8V0Y3N9
uniprot id: Q5F3H9
names: Subcellular Location Annotation
messages: Nucleus

9031:STT3A
gene id: 9031:STT3A
uniprot id: Q5ZLA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9031:CHEK1
gene id: 9031:CHEK1
uniprot id: Q8AYC9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated through phosphorylation by atr or atm in response to DNA damage or inhibition of DNA replication.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by ATR in a RAD17-dependent manner in response to ultraviolet irradiation and inhibition of DNA replication. Phosphorylated by ATM in response to ionizing irradiation (By similarity). Phosphorylation at Ser-345 induces a change in the conformation of the protein and activates the kinase activity. Phosphorylation at Ser-345 also increases binding to 14-3-3 proteins and promotes nuclear retention (PubMed:12554671).
messages: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:12554671). May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. This inhibits their activity through proteasomal degradation, nucleo-cytoplasmic shuttling and inhibition by proteins of the 13-3-3 family. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May promote DNA repair, regulate chromatin assembly and the transcription of genes that regulate cell-cycle progression. May also play a role in replication fork maintenance (By similarity).
messages: The autoinhibitory region (AIR) inhibits the activity of the kinase domain.
messages: centrosome

9031:CDC26
gene id: 9031:CDC26
uniprot id: A0A3Q2UD09
names: Similarity
messages: Belongs to the CDC26 family.

9031:SNRPA1
gene id: 9031:SNRPA1
uniprot id: Q5ZKP1
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9031:C9orf64
gene id: 9031:C9orf64
uniprot id: E1C455
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

9031:MYF5
gene id: 9031:MYF5
uniprot id: Q08856
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9031:FUT11
gene id: 9031:FUT11
uniprot id: Q8AWC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Probable fucosyltransferase.

9031:ITGA1
gene id: 9031:ITGA1
uniprot id: O42094
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9031:ZFYVE27
gene id: 9031:ZFYVE27
uniprot id: Q5ZL36
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers (monomers, dimers and tetramers).
messages: Endoplasmic reticulum membrane
messages: Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections.
messages: Recycling endosome membrane
messages: growth cone membrane

9031:CDKN1A
gene id: 9031:CDKN1A
uniprot id: M9TKU1
uniprot id: Q8AYE7
names: Similarity
messages: Belongs to the CDI family.

9031:FGF12
gene id: 9031:FGF12
uniprot id: A0A1D5PQL5
uniprot id: Q9IAI7
uniprot id: Q9W6A1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:LGALSL
gene id: 9031:LGALSL
uniprot id: Q5ZHQ2
names: Caution
names: Function
messages: Does not bind lactose, and may not bind carbohydrates.
messages: Most of the residues in the galectin domain that have been shown to be critical for carbohydrate-binding in other galectins are not conserved.

9031:CHST12
gene id: 9031:CHST12
uniprot id: E1BR90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:EGF
gene id: 9031:EGF
uniprot id: Q6PPB4
names: Caution
names: Function
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
messages: Interacts with EGFR and promotes EGFR dimerization.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PSMB7
gene id: 9031:PSMB7
uniprot id: Q7ZT63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9031:HNRNPA1
gene id: 9031:HNRNPA1
uniprot id: A0A8V0ZQM4
uniprot id: A0A8V0ZRC6
uniprot id: Q5ZLB3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:SRFBP1
gene id: 9031:SRFBP1
uniprot id: E1C0L6
names: Function
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

9031:SSTR2
gene id: 9031:SSTR2
uniprot id: Q58G84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9031:IL2RA
gene id: 9031:IL2RA
uniprot id: Q90WJ4
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9031:LSM14B
gene id: 9031:LSM14B
uniprot id: A0A1D5PS81
uniprot id: A0A8V0ZRX9
names: Similarity
messages: Belongs to the LSM14 family.

9031:CSRP2
gene id: 9031:CSRP2
uniprot id: P50460
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Totally down-regulated in transformed cells. May therefore take part in the control of cell growth and differentiation.

9031:COA7
gene id: 9031:COA7
uniprot id: A0A1D5PGZ5
uniprot id: A0A1D5PPW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

9031:AARSD1
gene id: 9031:AARSD1
uniprot id: F1NC49
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9031:PIF1
gene id: 9031:PIF1
uniprot id: A0A8V0ZR10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
messages: Mitochondrion
messages: Monomer.
messages: Nucleus

9031:ANXA6
gene id: 9031:ANXA6
uniprot id: P51901
uniprot id: Q6B344
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Cytoplasm
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores (By similarity).
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

9031:CYLD
gene id: 9031:CYLD
uniprot id: A0A8V0ZJC8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9031:EDA2R
gene id: 9031:EDA2R
uniprot id: A2SWM7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:HSPB9
gene id: 9031:HSPB9
uniprot id: A0A8V0ZLR4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

9031:CCDC124
gene id: 9031:CCDC124
uniprot id: A0A8V1ACL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC124 family.
messages: Midbody

9031:ORM1
gene id: 9031:ORM1
uniprot id: Q8JIG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Functions as transport protein in the blood stream.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9031:TMEM50A
gene id: 9031:TMEM50A
uniprot id: A0A1D5P292
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9031:TBR1
gene id: 9031:TBR1
uniprot id: A0A1D5P6N0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:ATP10B
gene id: 9031:ATP10B
uniprot id: E1BX05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:CERS2
gene id: 9031:CERS2
uniprot id: A0A8V1AL62
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9031:WNT2B
gene id: 9031:WNT2B
uniprot id: Q98SN7
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At stage 11, expressed in the medial sites of the embryonic right and left coelom, as well as in the medial region of the forming somites. Between stages 14 and 16, expression in the presumptive wing field, with strongest expression at stage 15. At stage 17, a faint expression is detected in the posterior region of the nascent limb bud. Expressed in the ocular surface ectoderm, including the corneal epithelium, starting from the onset of the lens vesicle closing at stage 16.
messages: Belongs to the Wnt family.
messages: Detected at the marginal tip of the developing retina (PubMed:12490564). Expressed in the intermediate and the lateral plate mesoderm in the presumptive chick forelimb region. Expressed in the eye, head ectoderm, prospective forelimb mesenchyme, lung bud, pharyngeal arches, the brain and otic vesicle.
messages: Interacts with FZD4 and FZD5.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (PubMed:12490564). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:12490564). Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo (PubMed:11290326).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: Was initially thought to be WNT13.
messages: extracellular matrix

9031:SYPL1
gene id: 9031:SYPL1
uniprot id: R4GKH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9031:CTSS
gene id: 9031:CTSS
uniprot id: Q5ZMR6
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:UBA5
gene id: 9031:UBA5
uniprot id: Q6IVA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Cytoplasm
messages: E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Homodimer; homodimerization is required for UFM1 activation. Interacts (via UIS motif) with UFM1; binds UFM1 via a trans-binding mechanism in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Interacts (via C-terminus) with UFC1.
messages: Nucleus

9031:LOC420160
gene id: 9031:LOC420160
uniprot id: A0A1D5PFI5
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:PTGES
gene id: 9031:PTGES
uniprot id: E2IPN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9031:PIK3C2A
gene id: 9031:PIK3C2A
uniprot id: A0A8V0ZLS9
uniprot id: E1C1G0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:TES
gene id: 9031:TES
uniprot id: Q90YH9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. May play a role in the regulation of cell proliferation. May inhibit cell growth (By similarity).
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with other proteins.
messages: focal adhesion

9031:B4GALT6
gene id: 9031:B4GALT6
uniprot id: Q5F3E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:AREG
gene id: 9031:AREG
uniprot id: Q645M5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CTSO
gene id: 9031:CTSO
uniprot id: Q5ZMK0
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:MANBAL
gene id: 9031:MANBAL
uniprot id: A0A1D5NZB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9031:LOC431316
gene id: 9031:LOC431316
uniprot id: A0A1D5PAN7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:BTC
gene id: 9031:BTC
uniprot id: Q64EU6
uniprot id: Q6B4U6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ACAA2
gene id: 9031:ACAA2
uniprot id: Q5ZLW8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9031:BRAF
gene id: 9031:BRAF
uniprot id: Q04982
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed preferentially in neural tissue.
messages: In quiescent cells, maintained in an inactive state via an intramolecular interaction between the protein kinase and N-terminal domains. Following mitogen-mediated cell activation, binds via its RGB domain to active HRAS (GTP-bound) which releases the inhibitory intramolecular interaction between the two domains. This allows the MAP2K1-mediated dimerization of KSR1 or KSR2, and BRAF which activates BRAF.
messages: Nucleus
messages: Protein kinase involved in the activation of the MAP signaling cascade. May play a role in transducing specific signals in neural cells.

9031:KCNJ5
gene id: 9031:KCNJ5
uniprot id: F1P3M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9031:B3GNT5
gene id: 9031:B3GNT5
uniprot id: A0A1D5PGR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:METTL14
gene id: 9031:METTL14
uniprot id: Q5ZK35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of METTL3 and METTL14.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing.

9031:PLXNA1
gene id: 9031:PLXNA1
uniprot id: A0A8V0ZNY6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:OSMR
gene id: 9031:OSMR
uniprot id: A0A8V0YLX6
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9031:CNDP2
gene id: 9031:CNDP2
uniprot id: Q5ZLV5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9031:UTP15
gene id: 9031:UTP15
uniprot id: Q5F3D7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome.
messages: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

9031:B4GALT5
gene id: 9031:B4GALT5
uniprot id: A0A8V0YI53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:SYNGR2
gene id: 9031:SYNGR2
uniprot id: Q5ZM48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9031:SLC6A8
gene id: 9031:SLC6A8
uniprot id: A0A1L1RLR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:RARA
gene id: 9031:RARA
uniprot id: Q90966
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Expressed from day 7-8.5 during feather morphogenesis in dermal and epidermal cells. Also expressed in heart from day 8.5-14.5. At later stages, when the feather follicle forms, expression still abundant in the epidermis, especially in the feather barb ridges.
messages: Heterodimer; with an RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.
messages: Nucleus
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning and appears to be required for skin development.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Ubiquitous.

9031:MED1
gene id: 9031:MED1
uniprot id: E1BUI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9031:APOA4
gene id: 9031:APOA4
uniprot id: O93601
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9031:PGA5
gene id: 9031:PGA5
uniprot id: Q9PRG9
names: Similarity
messages: Belongs to the peptidase A1 family.

9031:TFB1M
gene id: 9031:TFB1M
uniprot id: E1BWX0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9031:CD5
gene id: 9031:CD5
uniprot id: O73906
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ATP5G3
gene id: 9031:ATP5G3
uniprot id: E1BV48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9031:GRM4
gene id: 9031:GRM4
uniprot id: A0A8V0ZXL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9031:ANXA7
gene id: 9031:ANXA7
uniprot id: E1C1D1
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9031:UBE2L3
gene id: 9031:UBE2L3
uniprot id: Q5ZKN7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:SLC44A5
gene id: 9031:SLC44A5
uniprot id: A0A1D5P952
uniprot id: A0A3Q3AVJ7
uniprot id: A0A8V0ZXN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9031:RAP2A
gene id: 9031:RAP2A
uniprot id: E1BQI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

9031:MYH10
gene id: 9031:MYH10
uniprot id: Q02015
uniprot id: Q789A4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:TMEM41B
gene id: 9031:TMEM41B
uniprot id: Q5ZIL6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Endomembrane system
messages: Endoplasmic reticulum membrane
messages: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Required for normal motor neuron development (By similarity).
messages: The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.

9031:TMEM184C
gene id: 9031:TMEM184C
uniprot id: Q5ZMP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM184 family.
messages: May play a role in cell growth.
messages: Membrane

9031:C1D
gene id: 9031:C1D
uniprot id: Q5ZHS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9031:GNPDA1
gene id: 9031:GNPDA1
uniprot id: Q5ZLA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9031:SIKE1
gene id: 9031:SIKE1
uniprot id: A0A8V1A7C6
uniprot id: Q5ZIH5
names: Similarity
messages: Belongs to the SIKE family.

9031:VDAC1
gene id: 9031:VDAC1
uniprot id: E1BYN7
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9031:ABCB9
gene id: 9031:ABCB9
uniprot id: A0A8V1A3B2
names: Subcellular Location Annotation
messages: Membrane

9031:TNFAIP1
gene id: 9031:TNFAIP1
uniprot id: Q5F3E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BACURD family.
messages: Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and RBX1.
messages: Cytoplasm
messages: Endosome
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

9031:SARAF
gene id: 9031:SARAF
uniprot id: Q5ZK00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:GOLGA7
gene id: 9031:GOLGA7
uniprot id: Q5ZLC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERF4 family.
messages: Golgi apparatus membrane
messages: Interacts with ZDHHC9.
messages: May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity).

9031:TMEM123
gene id: 9031:TMEM123
uniprot id: Q5ZHZ6
uniprot id: Q5ZJI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9031:AK4
gene id: 9031:AK4
uniprot id: A0A8V0ZQU1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9031:DNAJC18
gene id: 9031:DNAJC18
uniprot id: E1C5R7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:PCMT1
gene id: 9031:PCMT1
uniprot id: Q5F3N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.
messages: Monomer.
messages: cytosol

9031:TRMT61A
gene id: 9031:TRMT61A
uniprot id: F1NZ19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9031:CFTR
gene id: 9031:CFTR
uniprot id: A0M8U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
messages: Membrane
messages: Recycling endosome membrane

9031:LOC101751614
gene id: 9031:LOC101751614
uniprot id: A0A8V1AJQ6
names: Similarity
messages: Belongs to the avian keratin family.

9031:SEC16A
gene id: 9031:SEC16A
uniprot id: A0A8V1A7G0
uniprot id: A0A8V1AJE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

9031:RPLP2
gene id: 9031:RPLP2
uniprot id: A0A1D5PMT8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9031:DD1CR
gene id: 9031:DD1CR
uniprot id: B7U502
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:HRAS
gene id: 9031:HRAS
uniprot id: P08642
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

9031:FGF9
gene id: 9031:FGF9
uniprot id: Q7ZZN4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:MRPS9
gene id: 9031:MRPS9
uniprot id: A0A1D5P607
uniprot id: A0A8V0YCQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Nucleus

9031:TCEB1
gene id: 9031:TCEB1
uniprot id: Q5ZJT7
names: Similarity
messages: Belongs to the SKP1 family.

9031:EPS8L2
gene id: 9031:EPS8L2
uniprot id: A0A8V0ZP51
names: Similarity
messages: Belongs to the EPS8 family.

9031:EIF2S1
gene id: 9031:EIF2S1
uniprot id: Q5ZLX2
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is regulated by phosphorylation at Ser-49 and Ser-52, which stabilizes the eIF2/GDP/eIF-2B complex and prevents the eIF-2B-mediated exchange of GDP for GTP, thereby preventing the formation of the 43S pre-initiation complex (43S PIC). This results in the global attenuation of 5' cap-dependent protein synthesis and concomitant translation of ISR-specific mRNAs that contain a short upstream open reading frame (uORF) in their 5' UTR.
messages: Belongs to the eIF-2-alpha family.
messages: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1.
messages: Phosphorylation at Ser-49 and Ser-52 stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation, while concomitantly initiating the preferential translation of integrated stress response (ISR)-specific mRNAs.
messages: Stress granule
messages: eIF2 is an heterotrimer composed of an alpha (EIF2S1), a beta (EIF2S2) and a gamma (EIF2S3) chain.

9031:SLC4A4
gene id: 9031:SLC4A4
uniprot id: A0A8V0XP11
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9031:VGLL1
gene id: 9031:VGLL1
uniprot id: A0A8V0YHT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9031:SLC10A7
gene id: 9031:SLC10A7
uniprot id: A0A8V0XLN1
uniprot id: A0A8V0XSZ8
uniprot id: E1BU54
uniprot id: Q5ZJH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates.

9031:PTGER3
gene id: 9031:PTGER3
uniprot id: Q1KMR2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:LRRC59
gene id: 9031:LRRC59
uniprot id: Q5F334
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Interacts with SGO1.
messages: Microsome membrane
messages: Nucleus envelope
messages: Required for nuclear import of FGF1.

9031:FSCN1
gene id: 9031:FSCN1
uniprot id: D5LPR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9031:PKIB
gene id: 9031:PKIB
uniprot id: A0A8V0YH48
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9031:LOC418701
gene id: 9031:LOC418701
uniprot id: A0A8V0YVD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 23 family.
messages: Secreted

9031:SEPTIN14
gene id: 9031:SEPTIN14
uniprot id: E1BV11
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9031:NDP
gene id: 9031:NDP
uniprot id: E1BWM4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:ACSL5
gene id: 9031:ACSL5
uniprot id: Q5ZIG7
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

9031:MID1
gene id: 9031:MID1
uniprot id: Q71R46
uniprot id: Q90WD1
names: Subcellular Location Annotation
messages: cytoskeleton

9031:LOC418170
gene id: 9031:LOC418170
uniprot id: E1BVD1
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9031:IFITM10
gene id: 9031:IFITM10
uniprot id: A0A1D5NV57
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9031:SP8
gene id: 9031:SP8
uniprot id: Q64HY5
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Detected in early stages of embryos as an oval and 2 stripes at HH stage 5, which becomes two lateral stripes at HH stage 7, running along the anteroposterior body axis from the head ectoderm to the anterior region of the primitive streak. At HH stage 8, strong expression in the anterior neuroectoderm, which forms the central nervous system, is observed, and at HH stage 9, expressed in the most anterior region of the forebrain, midbrain, neural groove and Hensen's node. At HH stage 15-16, the expression is seen in the surface ectoderm of the limb-forming fields, in addition to the neural tube. The expression in the limb field became confined to the distal region of the limb at HH stage 16 and 17, with still scattered signal visible in the surface ectoderm of the limb bud. Strongly expressed in the apical ectodermal ridge (AER) and weakly in the ectoderm in the developing limb bud at HH stage 21. The expression in the AER is detected throughout later stages of limb development.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.

9031:RNH1
gene id: 9031:RNH1
uniprot id: Q5ZIY8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

9031:PCBP3
gene id: 9031:PCBP3
uniprot id: A0A8V0YNB8
uniprot id: A0A8V0YV85
names: Subcellular Location Annotation
messages: Cytoplasm

9031:HIST1H4D
gene id: 9031:HIST1H4D
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:TRHR
gene id: 9031:TRHR
uniprot id: O93603
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9031:NRN1L
gene id: 9031:NRN1L
uniprot id: A0A3Q3AUX4
names: Similarity
messages: Belongs to the neuritin family.

9031:UBE2G1
gene id: 9031:UBE2G1
uniprot id: Q5ZLH8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:CPN1
gene id: 9031:CPN1
uniprot id: E1C7M0
names: Similarity
messages: Belongs to the peptidase M14 family.

9031:MYC
gene id: 9031:MYC
uniprot id: A0A167VDX5
uniprot id: P01109
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Alternative translation initiation from an upstream, in-frame non-ATG (ATT) codon or a downstream ATG start site results in the production of 2 isoforms with distinct N-termini, shown in this entry as isoform 2 and isoform 1, respectively.
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
messages: In cell culture, down-regulated as cells approach high densities (at protein level).
messages: Nucleus
messages: Produced by alternative translation initiation from a ATT codon, which is translated as Met.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
messages: Up-regulated in cultured cells by methionine deprivation (at protein level).

9031:RPL36
gene id: 9031:RPL36
uniprot id: Q98TF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL36 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: cytosol

9031:TLR7
gene id: 9031:TLR7
uniprot id: A0A1L4FML6
uniprot id: Q5ZJD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane
messages: phagosome

9031:SLC5A12
gene id: 9031:SLC5A12
uniprot id: F1NJG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9031:DYNC1LI1
gene id: 9031:DYNC1LI1
uniprot id: Q90828
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity). May regulate the movement of peripheral sorting endosomes along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (By similarity).
messages: Belongs to the dynein light intermediate chain family.
messages: Cytoplasm
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs) (By similarity).
messages: Phosphorylated.
messages: Recycling endosome membrane
messages: cytoskeleton
messages: kinetochore
messages: spindle pole

9031:ENTPD6
gene id: 9031:ENTPD6
uniprot id: A0A1L1RPW8
uniprot id: A0A8V0YYE8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9031:FN1
gene id: 9031:FN1
uniprot id: P11722
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).
messages: Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
messages: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN7 (By similarity).
messages: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix.
messages: Sulfated.
messages: extracellular matrix

9031:CDH2
gene id: 9031:CDH2
uniprot id: P10288
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (PubMed:2831236). Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). Required for proper neurite branching, and pre- and postsynaptic organization (PubMed:29760652).
messages: Cell junction
messages: Cell membrane
messages: Cell surface
messages: Detected in embryonic brain and heart (at protein level) (PubMed:1638632). Detected in embryonic brain and heart (PubMed:2831236).
messages: Homodimer (via extracellular region). Can also form heterodimers with other cadherins (via extracellular region). Dimerization occurs in trans, i.e. with a cadherin chain from another cell (By similarity). Interacts with CTNNA2 (PubMed:1638632).
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1.
messages: adherens junction
messages: desmosome
messages: sarcolemma

9031:PSKH1
gene id: 9031:PSKH1
uniprot id: E1BX19
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:CRYGN
gene id: 9031:CRYGN
uniprot id: D0FH75
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9031:SLC22A1
gene id: 9031:SLC22A1
uniprot id: A0A8V0XSD3
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9031:H1F0
gene id: 9031:H1F0
uniprot id: P02259
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Erythroid cells.
messages: Histone H5 performs the same function as H1, being necessary for the condensation of nucleosome chains into higher order structures, and replaces histone H1 in certain cells.
messages: Nucleus

9031:TIMM13
gene id: 9031:TIMM13
uniprot id: R4GGQ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9031:HOOK3
gene id: 9031:HOOK3
uniprot id: A0A8V0Y7B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9031:TRAF3
gene id: 9031:TRAF3
uniprot id: A0A3Q2UB30
uniprot id: A0A3Q2UF43
uniprot id: A0A3Q3AAA5
uniprot id: E1BW11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9031:SEC62
gene id: 9031:SEC62
uniprot id: Q5F3A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Part of a complex that contains SEC61, SEC62 and SEC63.
messages: Required for preprotein translocation.

9031:MECOM
gene id: 9031:MECOM
uniprot id: A0A1D5P950
names: Subcellular Location Annotation
messages: Nucleus

9031:CHAT
gene id: 9031:CHAT
uniprot id: Q90YJ9
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
messages: Detected in brain and in embryonic retina.

9031:CANX
gene id: 9031:CANX
uniprot id: Q5ZMF5
names: Similarity
messages: Belongs to the calreticulin family.

9031:CD9
gene id: 9031:CD9
uniprot id: Q9IBC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

9031:WNT6
gene id: 9031:WNT6
uniprot id: Q3C2H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:SATB2
gene id: 9031:SATB2
uniprot id: E1BZL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9031:CYB561
gene id: 9031:CYB561
uniprot id: E1C8U5
names: Subcellular Location Annotation
messages: Membrane

9031:SERINC2
gene id: 9031:SERINC2
uniprot id: Q5ZJZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9031:RRM2
gene id: 9031:RRM2
uniprot id: E1BXP4
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9031:PDCD5
gene id: 9031:PDCD5
uniprot id: A0A8V1A468
names: Similarity
messages: Belongs to the PDCD5 family.

9031:FOPNL
gene id: 9031:FOPNL
uniprot id: Q5ZJ24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CEP43 family.
messages: Cytoplasmic granule
messages: Homooligomer; probably required for localization to centrosomes.
messages: Involved in the biogenesis of cilia (By similarity). Required for the recruitment of PLK1 to centrosomes and S phase progression (By similarity).
messages: centriolar satellite
messages: centrosome
messages: cilium
messages: cilium basal body

9031:GMDS
gene id: 9031:GMDS
uniprot id: A0A1D5PD70
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9031:NR4A3
gene id: 9031:NR4A3
uniprot id: E1BYS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:C2orf49
gene id: 9031:C2orf49
uniprot id: Q5ZK74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9031:CECR1
gene id: 9031:CECR1
uniprot id: F1NML7
uniprot id: Q5ZJV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

9031:PCSK7
gene id: 9031:PCSK7
uniprot id: Q5ZKB5
names: Similarity
messages: Belongs to the peptidase S8 family.

9031:DNMT1
gene id: 9031:DNMT1
uniprot id: Q92072
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Homodimer (By similarity). Interacts with PCNA (PubMed:9302295).
messages: Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing.
messages: Nucleus
messages: Testis and lung.

9031:HISTH2A4L1
gene id: 9031:HISTH2A4L1
uniprot id: P02263
uniprot id: Q92069
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).
messages: Monoubiquitination of Lys-120 (H2AK119Ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties, leading to the recruitment of repair proteins to sites of DNA damage. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:PELI3
gene id: 9031:PELI3
uniprot id: A0A8V0Z864
uniprot id: Q5ZKT7
names: Similarity
messages: Belongs to the pellino family.

9031:MAP2K2
gene id: 9031:MAP2K2
uniprot id: A0A8V1AAM3
uniprot id: Q90891
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation on Ser/Thr catalyzed by MAP kinase kinase kinases (RAF).
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).

9031:TIRAP
gene id: 9031:TIRAP
uniprot id: Q4U127
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

9031:IDH2
gene id: 9031:IDH2
uniprot id: Q5ZL82
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9031:C2H6orf52
gene id: 9031:C2H6orf52
uniprot id: A0A1D5NX87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Nucleus

9031:RNF145
gene id: 9031:RNF145
uniprot id: E1C258
names: Subcellular Location Annotation
messages: Membrane

9031:TMEM14C
gene id: 9031:TMEM14C
uniprot id: A0A1D5PLN3
names: Similarity
messages: Belongs to the TMEM14 family.

9031:ERO1B
gene id: 9031:ERO1B
uniprot id: A0A8V0Y127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9031:MAGI3
gene id: 9031:MAGI3
uniprot id: Q5F488
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes.
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: tight junction

9031:BCL9
gene id: 9031:BCL9
uniprot id: A0A1D5PQ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9031:SLC16A8
gene id: 9031:SLC16A8
uniprot id: Q90632
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: First detected at embryonic day 5 (5 dpc) in both apical and basolateral membranes. By 14 dpc the distribution is restricted to the basolateral surface of retinal pigment epithelium. Restricted to the basolateral membrane in adult.
messages: Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (Probable). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity).
messages: Retinal pigment epithelium.
messages: The two basolateral sorting signals (BSS) are required to direct SLC16A8 to the basolateral membrane.

9031:FBN1
gene id: 9031:FBN1
uniprot id: A0A8V0ZDK1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:HSPB7
gene id: 9031:HSPB7
uniprot id: E1BV54
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

9031:LAT2
gene id: 9031:LAT2
uniprot id: Q5S7W5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells. May also be involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization through the recruitment of GRB2.
messages: Phosphorylated on tyrosines following cross-linking of BCR; which induces the recruitment of GRB2.
messages: When phosphorylated, interacts with GRB2.

9031:DESI2
gene id: 9031:DESI2
uniprot id: Q5ZIV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeSI family.
messages: Cytoplasm
messages: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9031:LIPG
gene id: 9031:LIPG
uniprot id: A0A1D5P986
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:PPP1CC
gene id: 9031:PPP1CC
uniprot id: Q5ZL39
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.

9031:CAPZA2
gene id: 9031:CAPZA2
uniprot id: A0M8U0
uniprot id: P28497
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line.
messages: Heterodimer of an alpha and a beta subunit.
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex (By similarity).
messages: Present in all tissues examined.
messages: Z line

9031:EYA2
gene id: 9031:EYA2
uniprot id: A0A8V0ZPI4
uniprot id: Q9YI56
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9031:CTSC
gene id: 9031:CTSC
uniprot id: A0A8V0XNR7
names: Similarity
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9031:TARS
gene id: 9031:TARS
uniprot id: Q5ZLW1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9031:PODXL
gene id: 9031:PODXL
uniprot id: A0A8V0XU83
uniprot id: O57604
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the podocalyxin family.
messages: Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes (By similarity). The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with NHERF1 and for targeting NHERF1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation.
messages: Cell membrane
messages: Expressed in thrombocytes, kidney podocytes, vascular endothelia and mono- and multipotent progenitors from the bone marrow (at protein level).
messages: Expressed on the surface of extra- and intraembryonic hematopoietic cells, neural tube, aorta, glomerulus, liver, heart and coelomic cavity in 4 day old embryo; in each of these tissues, detection is restricted to cells comprising the lumenal surfaces of tissues or boundary elements between tissues such as in the liver capsule, aorta, mesonephros, coelomic cavity and the central canal of the neural tube. Expressed in multipotent progenitors of day three yolk sac (at protein level).
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells (By similarity). Induces the formation of apical actin-dependent microvilli.
messages: Membrane
messages: Membrane raft
messages: N- and O-linked glycosylated. Sialoglycoprotein (By similarity).
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

9031:OTX5
gene id: 9031:OTX5
uniprot id: Q06AC6
names: Subcellular Location Annotation
messages: Nucleus

9031:KCND3
gene id: 9031:KCND3
uniprot id: A0A1D5P8P4
uniprot id: Q9PTD3
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

9031:GSTM2
gene id: 9031:GSTM2
uniprot id: P20136
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity) (PubMed:10903867). Participates in the formation of novel hepoxilin regioisomers (By similarity).
messages: Cytoplasm
messages: Homodimer.

9031:GPR65
gene id: 9031:GPR65
uniprot id: F1NJ83
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:RANBP10
gene id: 9031:RANBP10
uniprot id: A0A8V0ZMA2
uniprot id: F1NUL5
names: Similarity
messages: Belongs to the RANBP9/10 family.

9031:CCDC80
gene id: 9031:CCDC80
uniprot id: Q8AXP2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC80 family.
messages: Binds to various extracellular matrix proteins.
messages: Isoform 2 is expressed in the lens placode at stage 14. Isoform 1 is expressed in the lens vesicle at stage 17. Isoform 1 and isoform 2 are expressed in the lens, isthmus, cranial neuronal tube, dermatome and vitelin vein at stage 19. Isoform 1 and isoform 2 are expressed in the lens equatorial region during 4.5 dpc to 10 dpc.
messages: Promotes cell adhesion and matrix assembly (By similarity). May play a role in eye formation.
messages: extracellular matrix

9031:LHX9
gene id: 9031:LHX9
uniprot id: A0A8V0Y4F1
uniprot id: Q90881
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in the limb mesenchyme throughout stages 16 to 32. Expressed in the prospective wing bud at stage 16. Expressed in the leg bud at stage 17. Expressed in the forebrain throughout stages 14 to 21.
messages: May be involved in gonadal development.
messages: Nucleus

9031:MYL12A
gene id: 9031:MYL12A
uniprot id: P24032
names: Function
names: Miscellaneous
names: PTM
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).
messages: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity.
messages: This chain binds calcium.

9031:POFUT1
gene id: 9031:POFUT1
uniprot id: Q8AWB4
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

9031:LZIC
gene id: 9031:LZIC
uniprot id: Q5ZKW2
names: Similarity
names: Subunit
messages: Belongs to the CTNNBIP1 family.
messages: Does not interact with CTNNB1.

9031:SLC25A14
gene id: 9031:SLC25A14
uniprot id: Q5ZJX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:PSMA6
gene id: 9031:PSMA6
uniprot id: F1NEQ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9031:SSR3
gene id: 9031:SSR3
uniprot id: R4GJK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9031:TP53INP1
gene id: 9031:TP53INP1
uniprot id: A0A1D5PSS7
uniprot id: A0A8V0YET2
uniprot id: Q5F460
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9031:KIF11
gene id: 9031:KIF11
uniprot id: Q5ZMS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle pole

9031:IL5
gene id: 9031:IL5
uniprot id: Q5W4T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9031:HIST1H2BO
gene id: 9031:HIST1H2BO
uniprot id: P0C1H3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct.
messages: Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:RPL13
gene id: 9031:RPL13
uniprot id: P41125
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL13 family.
messages: Component of the 60S large ribosomal subunit (LSU).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs.
messages: Cytoplasm

9031:VEGFD
gene id: 9031:VEGFD
uniprot id: A0A1L1RNL9
uniprot id: F1NHR2
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9031:YWHAH
gene id: 9031:YWHAH
uniprot id: Q5ZKJ2
names: Similarity
messages: Belongs to the 14-3-3 family.

9031:RHOC
gene id: 9031:RHOC
uniprot id: Q9PSX7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Cleavage furrow
messages: Detected in embryonic notochord.
messages: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity).

9031:PPP1R16B
gene id: 9031:PPP1R16B
uniprot id: Q5ZHY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:FABP1
gene id: 9031:FABP1
uniprot id: Q90WA9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9031:LOC431321
gene id: 9031:LOC431321
uniprot id: A0A8V1AAE8
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:LOC121106490
gene id: 9031:LOC121106490
uniprot id: A0A1D5P312
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:HACD4
gene id: 9031:HACD4
uniprot id: R4GIV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SKIL
gene id: 9031:SKIL
uniprot id: Q05951
names: Similarity
messages: Belongs to the SKI family.

9031:ADGRB3
gene id: 9031:ADGRB3
uniprot id: A0A3Q2TVT9
uniprot id: A0A3Q2UBW1
uniprot id: A0A3Q2UE52
uniprot id: E1BZ18
names: Subcellular Location Annotation
messages: Membrane

9031:TRPC1
gene id: 9031:TRPC1
uniprot id: Q6DMS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9031:OPA1
gene id: 9031:OPA1
uniprot id: A0A1D5PM27
uniprot id: Q5F499
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity).
messages: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion membrane
messages: Oligomeric complex consisting of membrane-bound and soluble forms of OPA1. Binds PARL (By similarity).
messages: PARL-dependent proteolytic processing releases an antiapoptotic soluble form not required for mitochondrial fusion. Cleaved by OMA1 at position S1 following stress conditions.

9031:LOC396477
gene id: 9031:LOC396477
uniprot id: P02707
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Hepatic lectin is a membrane receptor protein that recognizes and binds exposed N-acetylglucosamine moieties of plasma glycoproteins, thus mediating their clearance (from the circulation) and endocytosis.
messages: Membrane
messages: Some or all of the cysteines are involved in disulfide bonds.

9031:LDHB
gene id: 9031:LDHB
uniprot id: P00337
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).

9031:NKIRAS2
gene id: 9031:NKIRAS2
uniprot id: Q5ZJW6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation.
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
messages: Cytoplasm
messages: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

9031:SERPINB6
gene id: 9031:SERPINB6
uniprot id: Q5ZLB6
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9031:CUX1
gene id: 9031:CUX1
uniprot id: Q90765
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Golgi apparatus membrane
messages: Membrane

9031:CKB
gene id: 9031:CKB
uniprot id: P05122
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Ba-CK and Bb-CK are phosphorylated.
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Cell membrane
messages: Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
messages: Expressed in almost all tissues and found enriched in various region of the brain, retina, heart, gizzard, gut and sperm.
messages: Mitochondrion
messages: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8525081, PubMed:20026305). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable).
messages: The N-terminus of BA-CK is blocked.
messages: cytosol

9031:GCK
gene id: 9031:GCK
uniprot id: A0A8V0ZFP3
names: Similarity
messages: Belongs to the hexokinase family.

9031:ARNTL2
gene id: 9031:ARNTL2
uniprot id: Q8QGQ7
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the BMAL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator.
messages: Expressed in the pineal gland.
messages: Expression in the pineal gland exhibits circadian rhythm. Maximum levels expressed at CT14, and between ZT14 and ZT18.
messages: Nucleus
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …

9031:GATAD1
gene id: 9031:GATAD1
uniprot id: F1P024
names: Subcellular Location Annotation
messages: Nucleus

9031:MTHFD1
gene id: 9031:MTHFD1
uniprot id: Q5ZI76
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9031:METTL9
gene id: 9031:METTL9
uniprot id: Q5ZMH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the METTL9 family.
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (By similarity). Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid); 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (By similarity).

9031:DAD1
gene id: 9031:DAD1
uniprot id: A2NR64
uniprot id: O13113
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9031:SGPL1
gene id: 9031:SGPL1
uniprot id: A0A8V0ZK58
uniprot id: F1NMD8
uniprot id: Q5ZMK8
names: Similarity
messages: Belongs to the group II decarboxylase family.

9031:SST7
gene id: 9031:SST7
uniprot id: A0MAR6
uniprot id: Q7T2S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9031:SLC34A1
gene id: 9031:SLC34A1
uniprot id: A0A1D5NWQ4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9031:VSNL1
gene id: 9031:VSNL1
uniprot id: P62764
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the recoverin family.
messages: Probably binds three calcium ions.
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.
messages: Widely expressed in the brain but not detectable in liver, heart or skeletal muscle.

9031:SLC7A9
gene id: 9031:SLC7A9
uniprot id: E5L8B7
names: Subcellular Location Annotation
messages: Membrane

9031:NDUFS5
gene id: 9031:NDUFS5
uniprot id: E1C5D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9031:INHBB
gene id: 9031:INHBB
uniprot id: P27093
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9031:ART4
gene id: 9031:ART4
uniprot id: B6RDJ8
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9031:KCNJ13
gene id: 9031:KCNJ13
uniprot id: A0A8V0ZXM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9031:LDAH
gene id: 9031:LDAH
uniprot id: A0A8V0XX01
uniprot id: Q5F477
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Endoplasmic reticulum
messages: Lipid droplet
messages: Probable serine lipid hydrolase associated with lipid droplets. Appears to lack cholesterol esterase activity. Appears to lack triglyceride lipase activity.
messages: The catalytic activity is unsure despite catalytic sites being conserved.

9031:ALDH1A3
gene id: 9031:ALDH1A3
uniprot id: Q9DD46
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9031:HIST1H101
gene id: 9031:HIST1H101
uniprot id: P08284
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

9031:CUL1
gene id: 9031:CUL1
uniprot id: A0A1D5P2L3
names: Similarity
messages: Belongs to the cullin family.

9031:VAPA
gene id: 9031:VAPA
uniprot id: Q5F419
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:KIF27
gene id: 9031:KIF27
uniprot id: A0A3Q2U8W8
uniprot id: E1C472
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:NCOR2
gene id: 9031:NCOR2
uniprot id: A0A8V1A155
names: Similarity
messages: Belongs to the N-CoR nuclear receptor corepressors family.

9031:CFAP20
gene id: 9031:CFAP20
uniprot id: Q5ZHP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP20 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation.
messages: Nucleus
messages: centriole
messages: cilium axoneme
messages: cilium basal body

9031:MAPKAPK2
gene id: 9031:MAPKAPK2
uniprot id: F1NCY7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:ETV4
gene id: 9031:ETV4
uniprot id: A0A8V1A142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:ODC
gene id: 9031:ODC
uniprot id: P27118
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
messages: Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.
messages: Inhibited by antizymes (AZs) in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.

9031:UPF1
gene id: 9031:UPF1
uniprot id: A0A8V1AHU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

9031:KLHL14
gene id: 9031:KLHL14
uniprot id: Q5F3N5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: cytosol

9031:LAMP2
gene id: 9031:LAMP2
uniprot id: Q90617
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAMP family.
messages: Cell membrane
messages: Endosome membrane
messages: Extensively N-glycosylated. Contains a minor proportion of O-linked glycans.
messages: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (By similarity). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (By similarity).
messages: Lysosome membrane
messages: Monomer. Forms large homooligomers.
messages: autophagosome membrane

9031:CNPPD1
gene id: 9031:CNPPD1
uniprot id: Q5ZJH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNPPD1 family.
messages: Membrane

9031:SLC25A32
gene id: 9031:SLC25A32
uniprot id: Q5ZJN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:SAMD4A
gene id: 9031:SAMD4A
uniprot id: A0A8V0Z834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9031:TMEM251
gene id: 9031:TMEM251
uniprot id: Q5ZLR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Golgi apparatus membrane
messages: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases.

9031:PAFAH1B1
gene id: 9031:PAFAH1B1
uniprot id: Q9PTR5
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with dynein, dynactin, NDE1 and NDEL1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Expressed in the intermediate and lateral mesoderm, posterior neural tube, notochord and somites of stage 9 embryos. Expressed in the neural tube, roof plate, notochord, somites, dermomymotomes and eye of stage 20 embryos. This expression pattern persists in stage 27 embryos, where expression is also seen in the heart, intestine and dorsal aorta. Weakly and uniformly expressed in the stage 35 embryo.
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
messages: centrosome
messages: cytoskeleton

9031:GDF3
gene id: 9031:GDF3
uniprot id: Q90723
uniprot id: Q98950
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9031:SMAD5
gene id: 9031:SMAD5
uniprot id: Q56I99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: May form trimers with the co-SMAD SMAD4.
messages: Nucleus
messages: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity).

9031:HOXD8
gene id: 9031:HOXD8
uniprot id: P23459
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:GRHL2
gene id: 9031:GRHL2
uniprot id: A0A8V0YCE3
names: Subcellular Location Annotation
messages: Nucleus

9031:LOC107052389
gene id: 9031:LOC107052389
uniprot id: A0A3Q2TSE5
names: Similarity
messages: Belongs to the SERF family.

9031:IKZF5
gene id: 9031:IKZF5
uniprot id: Q5ZLR2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Pegasus' was the winged horse in Greek mythology.
messages: Belongs to the Ikaros C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Probably self-associates.
messages: Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence.

9031:SLC16A2
gene id: 9031:SLC16A2
uniprot id: A0A142EGP9
names: Subcellular Location Annotation
messages: Membrane

9031:PTPN21
gene id: 9031:PTPN21
uniprot id: A0A1D5P6Q1
uniprot id: E1C5H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9031:TOMM7
gene id: 9031:TOMM7
uniprot id: A0A1L1RYN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9031:HOXB4
gene id: 9031:HOXB4
uniprot id: A0A8V0ZWE5
uniprot id: P14840
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:CTAGE1
gene id: 9031:CTAGE1
uniprot id: Q9I8P6
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MIA/OTOR family.
messages: Highly expressed in cochlea.
messages: Secreted

9031:TBXA2R
gene id: 9031:TBXA2R
uniprot id: A0A1D5P7R6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:CDS1
gene id: 9031:CDS1
uniprot id: F1NYE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9031:SOCS3
gene id: 9031:SOCS3
uniprot id: Q90X67
names: Domain
names: Function
names: PTM
names: Subunit
messages: Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and EPO receptor. Binding to JAK is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO and gp130 receptors.
messages: Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1.
messages: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
messages: The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

9031:DLL1
gene id: 9031:DLL1
uniprot id: Q90656
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9031:SRD5A2
gene id: 9031:SRD5A2
uniprot id: F1NUW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9031:NTRK2
gene id: 9031:NTRK2
uniprot id: Q91987
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Detected in embryonic brain and orsal root ganglia.
messages: Endosome membrane
messages: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor (By similarity). Interacts with SORCS2; this interaction is important for normal targeting to post-synaptic densities in response to high-frequency stimulation (By similarity). Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway (By similarity). Interacts with APPL1 (By similarity). Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (By similarity).
messages: It is unsure whether Leu-144 or Met-188 is the initiator of isoform 2.
messages: Ligand-mediated auto-phosphorylation.
messages: Postsynaptic density
messages: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4 (PubMed:8287802, PubMed:8670834). Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:8670834). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia (By similarity).
messages: Specifically activated by BDNF but not NTF3 and NTF4.
messages: The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity).
messages: axon
messages: dendrite
messages: perinuclear region

9031:BMP6
gene id: 9031:BMP6
uniprot id: A0A8V0Y5G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9031:ACSL1
gene id: 9031:ACSL1
uniprot id: Q5F420
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

9031:CYP1A2
gene id: 9031:CYP1A2
uniprot id: P79761
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:CYCS
gene id: 9031:CYCS
uniprot id: P67881
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

9031:ARMC1
gene id: 9031:ARMC1
uniprot id: Q5ZMQ0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Interacts with mitochondrial contact site and cristae organizing system (MICOS) complex components IMMT/MIC60 and MICOS10/MIC10 (By similarity). Interacts with mitochondrial outer membrane sorting assembly machinery (SAM) complex components SAMM50 and MTX1 (By similarity).
messages: Mitochondrion
messages: Mitochondrion outer membrane

9031:ARHGEF6
gene id: 9031:ARHGEF6
uniprot id: Q5ZLR6
names: Function
names: Subcellular Location Annotation
messages: Acts as a RAC1 guanine nucleotide exchange factor (GEF).
messages: lamellipodium

9031:PTBP1
gene id: 9031:PTBP1
uniprot id: A0A8V1ABY0
uniprot id: Q5F456
names: Subcellular Location Annotation
messages: Nucleus

9031:MORF4L2
gene id: 9031:MORF4L2
uniprot id: A0A8V0ZD42
names: Subcellular Location Annotation
messages: Nucleus

9031:TMEM231
gene id: 9031:TMEM231
uniprot id: F1NNL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM231 family.
messages: Part of the tectonic-like complex (also named B9 complex).
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: cilium membrane

9031:KIAA2022
gene id: 9031:KIAA2022
uniprot id: A0A8V0YMF7
names: Subcellular Location Annotation
messages: Nucleus

9031:CDK2AP2
gene id: 9031:CDK2AP2
uniprot id: A0A8V0ZMV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDK2AP family.
messages: Nucleus

9031:EPHB2
gene id: 9031:EPHB2
uniprot id: A0A8V0YRG2
uniprot id: P28693
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
messages: Cell membrane
messages: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
messages: Ligand binding induces cleavage by matrix metalloproteinases (MMPs) such as MMP7/MMP9, producing an EphB2/N-terminal fragment (NTF) and a C-terminal long fragment (EphB2-LF). EphB2-LF is further cleaved by MMPs, producing EphB2/CTF1 which is further cleaved by the PS1/gamma-secretase producing EphB2/CTF2.
messages: Membrane
messages: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses (By similarity).
messages: Wide tissue distribution throughout development and sustained expression in adult brain. The longer form (CEK5+) is specifically expressed in the central nervous system.
messages: axon
messages: dendrite

9031:GAB3
gene id: 9031:GAB3
uniprot id: A0A8V0YU15
names: Similarity
messages: Belongs to the GAB family.

9031:ELP3
gene id: 9031:ELP3
uniprot id: Q5ZHS1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
messages: Component of the elongator complex.
messages: Cytoplasm
messages: Nucleus
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

9031:PTX3
gene id: 9031:PTX3
uniprot id: Q5UMH8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:DYNC1H1
gene id: 9031:DYNC1H1
uniprot id: F1NKL4
names: Similarity
messages: Belongs to the dynein heavy chain family.

9031:TNR
gene id: 9031:TNR
uniprot id: A0A8V0XZF7
uniprot id: Q00546
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tenascin family.
messages: Brain specific.
messages: Expression weakly detectable at 6 dpc embryo, reaches a maximum at 16 dpc and declines in the adult.
messages: Forms homodimers and homotrimers. Interacts with CNTN1, NFASC and CSPG5.
messages: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Involved in cell attachment and neurite formation. Interaction with CNTN1 enhances the neurite outgrowth.
messages: The N-terminus cysteine-rich segment may mediate the formation of oligomers. The fibronectin type-III 2-3 mediate the binding to contactin 1. The fibronectin type-III 9 mediates the cell attachment. The fibronectin type-III 2-5 mediate NFASC binding. The fibrinogen C-terminal domain mediates interaction with CSPG5.
messages: extracellular matrix

9031:TRMU
gene id: 9031:TRMU
uniprot id: Q5ZKW0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
messages: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
messages: Mitochondrion

9031:PITX3
gene id: 9031:PITX3
uniprot id: A0A8V0Z8X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9031:SLC13A4
gene id: 9031:SLC13A4
uniprot id: A0A8V0YBN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9031:ST6GALNAC1
gene id: 9031:ST6GALNAC1
uniprot id: Q92183
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 29 family.
messages: Embryo.
messages: Golgi apparatus membrane
messages: Heart, kidney, testes, brain, liver and lung.
messages: Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (By similarity). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:8288607).

9031:NELFCD
gene id: 9031:NELFCD
uniprot id: Q5ZIQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

9031:SEC22B
gene id: 9031:SEC22B
uniprot id: Q5ZJW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptobrevin family.
messages: Component of 2 distinct SNARE complexes.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9031:BLOC1S5
gene id: 9031:BLOC1S5
uniprot id: Q5ZK77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking (By similarity).
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).

9031:MAPK8
gene id: 9031:MAPK8
uniprot id: A0A3Q2TY19
uniprot id: A0A8V0Z7M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9031:EMC7
gene id: 9031:EMC7
uniprot id: E1C0R9
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

9031:CHRM3
gene id: 9031:CHRM3
uniprot id: P49578
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
messages: Brain, heart atria, and ventricle.
messages: Cell membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9031:NPFFR2
gene id: 9031:NPFFR2
uniprot id: Q4AE91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9031:SLC25A13
gene id: 9031:SLC25A13
uniprot id: Q5ZIF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9031:FRZB
gene id: 9031:FRZB
uniprot id: Q9IA95
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At stage 7 of embryonic development, expressed in the neural plate with lower expression in the midline. At stage 9, expression restricted to the dorsal neural tube and cranial neural crest. At stage 12, expressed in the lateral plate mesoderm. In the developing trunk, expressed, from stages 9-12, in the ventral migrating neural crest with some expression at stage 12 in the dorsal streams From stage 15, expressed in the endocardial cells of the outflow tract of the developing heart. From stage 18, expression found in the epibranchial placodes, in endocardial and mesenchymal cells of the developing atrioventricular canal and of the outflow tract cushions. Expression in these regions of the developing heart continue until stage 26. During limb development, low expression found, by stage 18, in the developing limb buds, By stage 20, highly expressed in the ventral mesenchyme of both fore- and hind-limb buds. By stage 24, expression localized to the central core of the developing limb bud, which contains the chondrogenic precursors. Also expressed in the surrounding nonchondrogenic mesenchyme. Later expression confined to the perichondrium and to the epiphyses of the early developing skeletal elements.
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
messages: The FZ domain is involved in binding with Wnt ligands.

9031:MYT1
gene id: 9031:MYT1
uniprot id: A0A8V0ZM15
uniprot id: A0A8V0ZZS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9031:PAX3
gene id: 9031:PAX3
uniprot id: Q8QGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9031:TMEM43
gene id: 9031:TMEM43
uniprot id: E1BUH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

9031:CA2
gene id: 9031:CA2
uniprot id: P07630
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea.
messages: Cell membrane
messages: Cytoplasm
messages: Inhibited by acetazolamide.

9031:SRP14
gene id: 9031:SRP14
uniprot id: Q5ZIE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

9031:ADAMTS19
gene id: 9031:ADAMTS19
uniprot id: E1C0E3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:CPNE7
gene id: 9031:CPNE7
uniprot id: A0A8V0XR03
names: Similarity
messages: Belongs to the copine family.

9031:BICD1
gene id: 9031:BICD1
uniprot id: A0A8V0YMG5
uniprot id: A0A8V0YU86
uniprot id: A0A8V0Z0M1
names: Similarity
messages: Belongs to the BicD family.

9031:GPR37
gene id: 9031:GPR37
uniprot id: A1IHG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:PROM1
gene id: 9031:PROM1
uniprot id: A0A8V0Y739
uniprot id: E1C9E2
uniprot id: F1CLE7
uniprot id: F1CLE8
uniprot id: F1CLE9
uniprot id: F1CLF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9031:MOSPD1
gene id: 9031:MOSPD1
uniprot id: A0A8V0YV69
uniprot id: F1NE32
names: Subcellular Location Annotation
messages: Membrane

9031:SLC8A1
gene id: 9031:SLC8A1
uniprot id: Q000J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9031:SLC25A36
gene id: 9031:SLC25A36
uniprot id: Q5ZKP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism.
messages: Mitochondrion inner membrane

9031:MDM1
gene id: 9031:MDM1
uniprot id: Q5ZMW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.
messages: Nucleus
messages: centriole
messages: centrosome

9031:COX7A2
gene id: 9031:COX7A2
uniprot id: F1NWK2
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9031:TUBA5
gene id: 9031:TUBA5
uniprot id: A0A1D5PAR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:CLP1
gene id: 9031:CLP1
uniprot id: Q5ZJL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by dicer1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).

9031:MET
gene id: 9031:MET
uniprot id: Q90975
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SLC25A3
gene id: 9031:SLC25A3
uniprot id: A0A8V0Y9K6
uniprot id: Q5ZLZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9031:FIGN
gene id: 9031:FIGN
uniprot id: A0A8V1A487
names: Similarity
messages: Belongs to the AAA ATPase family.

9031:POLE2
gene id: 9031:POLE2
uniprot id: Q5ZKQ6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity).
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus

9031:CD82
gene id: 9031:CD82
uniprot id: Q5ZKY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:NR0B1
gene id: 9031:NR0B1
uniprot id: Q9PTE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

9031:RPA2
gene id: 9031:RPA2
uniprot id: Q5ZLH1
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

9031:INPP4B
gene id: 9031:INPP4B
uniprot id: A0A1D5PYC2
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9031:TRIM9
gene id: 9031:TRIM9
uniprot id: A0A3Q2U2G8
uniprot id: A0A8V0ZAN5
names: Subcellular Location Annotation
messages: cytoskeleton

9031:CRCP
gene id: 9031:CRCP
uniprot id: A0A8V1APQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9031:TMEM39B
gene id: 9031:TMEM39B
uniprot id: E1C8M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

9031:TOMM20
gene id: 9031:TOMM20
uniprot id: A0A1D5PKT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9031:DGAT2
gene id: 9031:DGAT2
uniprot id: A0A1D5PMU1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:AP2M1
gene id: 9031:AP2M1
uniprot id: Q5ZMP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids.
messages: coated pit

9031:SCFD2
gene id: 9031:SCFD2
uniprot id: A0A1D5NZ00
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9031:PARK7
gene id: 9031:PARK7
uniprot id: Q8UW59
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C56 family.
messages: Cell membrane
messages: Cytoplasm
messages: Deglycase activity does not require glutathione as a cofactor, however, glycated glutathione constitutes a PARK7 substrate.
messages: Endoplasmic reticulum
messages: Glyoxylase activity previously reported may reflect in fact its deglycase activity.
messages: Homodimer.
messages: Membrane raft
messages: Mitochondrion
messages: Nucleus
messages: Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity. Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease. It is involved in neuroprotective mechanisms as well as cell growth and transformation. Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury io…
messages: Sumoylated on Lys-130; which is essential for cell-growth promoting activity and transforming activity.
messages: The protein deglycation activity has been ascribed to a TRIS buffer artifact by a publication, which has then been rebutted by clear biochemical experiments showing that PARK7 is a bona fide deglycase. Deglycase activity is even strengthened by a novel article that reports nucleotide deglycation activity.
messages: Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress.

9031:ASIP
gene id: 9031:ASIP
uniprot id: B0ZDU3
names: Subcellular Location Annotation
messages: Secreted

9031:NDUFS8
gene id: 9031:NDUFS8
uniprot id: A0A1D5PE41
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

9031:DDR1
gene id: 9031:DDR1
uniprot id: Q5F3X2
names: Subcellular Location Annotation
messages: Membrane

9031:FAM105A
gene id: 9031:FAM105A
uniprot id: A0A1D5PWB5
uniprot id: F1NNA2
uniprot id: Q5ZK68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9031:AZIN1
gene id: 9031:AZIN1
uniprot id: A0A1D5PIE4
uniprot id: Q5ZJ04
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9031:SERPINE2
gene id: 9031:SERPINE2
uniprot id: A0A1D5PLJ1
uniprot id: A0A8V0ZZS6
uniprot id: E1BWU2
names: Similarity
messages: Belongs to the serpin family.

9031:YWHAB
gene id: 9031:YWHAB
uniprot id: Q5ZLQ6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.
messages: Phosphorylated.

9031:RGS17
gene id: 9031:RGS17
uniprot id: Q9PWA0
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with GNAI1 and GNAQ (By similarity). Interacts with GNAZ and GNAI2. Forms a complex with mu-opioid receptors and G(alpha)z/i2 subunits, including GNAZ and GNAI2; the formation of this complex results in mu-opioid receptor desensitization (By similarity).
messages: Membrane
messages: N- and O-glycosylated in synapsomal membranes.
messages: Nucleus
messages: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
messages: Serine phosphorylated in synapsomal membranes.
messages: Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.
messages: synaptosome

9031:IAPP
gene id: 9031:IAPP
uniprot id: Q90743
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted

9031:USP7
gene id: 9031:USP7
uniprot id: Q6U7I1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Chromosome
messages: Cytoplasm
messages: Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling.
messages: Nucleus
messages: PML body
messages: Phosphorylated.
messages: Polyneddylated.
messages: Polyubiquitinated.

9031:MAP7D1
gene id: 9031:MAP7D1
uniprot id: A0A8V0YPU7
names: Similarity
messages: Belongs to the MAP7 family.

9031:FAM76B
gene id: 9031:FAM76B
uniprot id: F1NYM6
names: Similarity
messages: Belongs to the FAM76 family.

9031:DCLRE1C
gene id: 9031:DCLRE1C
uniprot id: Q5QJC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Interacts with PRKDC.
messages: Nucleus
messages: Phosphorylation on undefined residues by PRKDC may stimulate endonucleolytic activity on 5' and 3' hairpins and overhangs. PRKDC must remain present, even after phosphorylation, for efficient hairpin opening (By similarity).
messages: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity).

9031:INTS10
gene id: 9031:INTS10
uniprot id: A0A1I7Q410
uniprot id: Q5ZLS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 10 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus

9031:SPPL3
gene id: 9031:SPPL3
uniprot id: E1C173
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9031:TMEM216
gene id: 9031:TMEM216
uniprot id: A0A1D5PGJ8
names: Subcellular Location Annotation
messages: Membrane

9031:RIOX1
gene id: 9031:RIOX1
uniprot id: Q5ZMM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. NO66 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (By similarity). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes demethylation of non-histone proteins (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity).
messages: nucleolus
messages: nucleoplasm

9031:INTS7
gene id: 9031:INTS7
uniprot id: Q5ZL91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 7 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Chromosome
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. May play a role in DNA damage response (DDR) signaling during the S phase.
messages: Nucleus

9031:TMEM9
gene id: 9031:TMEM9
uniprot id: F1NKS2
names: Similarity
messages: Belongs to the TMEM9 family.

9031:PER2
gene id: 9031:PER2
uniprot id: Q8QGQ8
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1E, and the PER proteins. Interacts directly with PER3, and through a C-terminal domain, with CRY1 and CRY2.
messages: Cytoplasm
messages: Exhibits circadian rhythm expression. Peak levels in early morning and low levels at early night.
messages: Nucleus
messages: Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …

9031:ROR2
gene id: 9031:ROR2
uniprot id: A0SVH2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SCAMP1
gene id: 9031:SCAMP1
uniprot id: A0A8V0YN78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9031:HAGH
gene id: 9031:HAGH
uniprot id: Q5ZI23
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.
messages: Produced by alternative initiation at Met-51 of isoform 1. Alternative initiation has been proven in human.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

9031:DDB2
gene id: 9031:DDB2
uniprot id: Q5ZJL7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Chromosome
messages: Component of the UV-DDB complex which includes DDB1 and DDB2 (By similarity). Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1), which includes CUL4A or CUL4B, DDB1, DDB2 and RBX1. DDB2 may function as the substrate recognition module within this complex. A large number of other DCX complexes may also exist in which an alternate substrate targeting subunit replaces DDB2. These targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins (By similarity).
messages: Interblade loops of the WD repeat region mediate most of the interaction with DNA. A hairpin between blades 5 and 6 inserts into DNA minor groove and mediates recognition of lesions and separation of the damaged and undamaged strands (By similarity).
messages: Nucleus
messages: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair.
messages: The DWD box is required for interaction with DDB1.

9031:FLRT3
gene id: 9031:FLRT3
uniprot id: F1NUK7
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell membrane
messages: Detected in distal ectodermal cells at Hamburger Hamilton stage 18 (18HH). Becomes restricted to the apical ectodermal ridge (AER) (at protein level). At stage 11HH, detected in neural ectoderm, developing optic placodes, the neural crest around the otic placodes, and along the anterior-posterior axis in somites. Detected in the ectoderm of the limb bud at 16HH to 18HH. Becomes restricted to the dermomyotome closer to the neural tube at stage 18HH. At 19HH and 23HH, detected in the apical ectodermal ridge, the developing eye and branchial arches.
messages: Endoplasmic reticulum membrane
messages: Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development (PubMed:21575622). Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC-5 family members. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning (By similarity).
messages: N-glycosylated.
messages: Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.
messages: Secreted
messages: axon
messages: focal adhesion
messages: growth cone membrane

9031:RPS27A
gene id: 9031:RPS27A
uniprot id: P79781
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 40S subunit of the ribosome. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Part of the 40S ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Ubiquitin Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
messages: Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.
messages: nucleolus

9031:INSIG1
gene id: 9031:INSIG1
uniprot id: Q5ZMT9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex; association is mediated via its interaction with SCAP and only takes place in the presence of sterols.
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs). Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBPs to the Golgi. Sterol deprivation reduces oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs. Also regulates cholesterol synthesis by regulating degradation of HMGCR.
messages: The KxHxx motif mediates association with the coatomer complex.

9031:KPTN
gene id: 9031:KPTN
uniprot id: A0A1D5PJB7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: Lysosome membrane
messages: May be part of the KICSTOR complex.
messages: lamellipodium
messages: stereocilium

9031:SMYD2
gene id: 9031:SMYD2
uniprot id: A0A0A0MQ47
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
messages: cytosol

9031:PIK3R1
gene id: 9031:PIK3R1
uniprot id: A0A1D5PUK7
uniprot id: A0A3Q3ACS4
uniprot id: E1C8M4
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9031:CBR3
gene id: 9031:CBR3
uniprot id: Q4JK63
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:SGK1
gene id: 9031:SGK1
uniprot id: A0A3Q2UHJ7
uniprot id: Q6U1I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus
messages: Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity).

9031:NDUFA6
gene id: 9031:NDUFA6
uniprot id: A0A1D5P4B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:HOXA6
gene id: 9031:HOXA6
uniprot id: Q5YLH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:GHRH
gene id: 9031:GHRH
uniprot id: Q1KNA7
uniprot id: Q1KNA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9031:GPR137C
gene id: 9031:GPR137C
uniprot id: F1NU49
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9031:VWC2
gene id: 9031:VWC2
uniprot id: A0A3Q2TT95
names: Subcellular Location Annotation
messages: Synapse

9031:SPTLC2
gene id: 9031:SPTLC2
uniprot id: Q5ZJ96
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9031:SMIM19
gene id: 9031:SMIM19
uniprot id: A0A1D5PP98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9031:HSDL2
gene id: 9031:HSDL2
uniprot id: E1C7S2
names: Subcellular Location Annotation
messages: Peroxisome

9031:DIAPH2
gene id: 9031:DIAPH2
uniprot id: Q9DEH3
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

9031:PBX1
gene id: 9031:PBX1
uniprot id: Q9IB15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9031:NOL11
gene id: 9031:NOL11
uniprot id: Q5ZL79
names: Function
names: Subcellular Location Annotation
messages: Ribosome biogenesis factor. May be required for both optimal rDNA transcription and pre-rRNA processing (By similarity).
messages: nucleolus

9031:POPDC3
gene id: 9031:POPDC3
uniprot id: Q9DG25
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the popeye family.
messages: Expressed first preferentially in atrium and later also in the subepicardial compact layer of the ventricles.
messages: Expression was first detected at HH stage 10 and was initially expressed throughout the heart. With heart looping at HH stage 11, expression was restricted to the atrial compartment and absent from the presumptive ventricular segments. The atrial-specific expression was still observed at stage 17. During HH stages 17-24, increased expression in the subepicardial compact layer was seen. At HH stage 30, expression was seen intensely in the whole myocardium with the exception of the outflow tract.
messages: May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding. May play a role in the regulation of KCNK2-mediated current amplitude (By similarity).
messages: Membrane

9031:PLA2G15
gene id: 9031:PLA2G15
uniprot id: A0A8V0ZSC5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9031:SLCO4A1
gene id: 9031:SLCO4A1
uniprot id: A0A8V0ZP49
uniprot id: Q5ZMP9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:NME8
gene id: 9031:NME8
uniprot id: A0A1D5PUV4
names: Similarity
messages: Belongs to the NDK family.

9031:NAP1L1
gene id: 9031:NAP1L1
uniprot id: A0A8V0YS67
uniprot id: E1BZS2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9031:YIPF5
gene id: 9031:YIPF5
uniprot id: E1C6B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9031:TUBA3E
gene id: 9031:TUBA3E
uniprot id: F1NWX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:HIST1H2A4L3
gene id: 9031:HIST1H2A4L3
uniprot id: P02263
uniprot id: Q92069
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).
messages: Monoubiquitination of Lys-120 (H2AK119Ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties, leading to the recruitment of repair proteins to sites of DNA damage. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:CCR5
gene id: 9031:CCR5
uniprot id: B2BJC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:CLDN10
gene id: 9031:CLDN10
uniprot id: E1C926
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:TMED10
gene id: 9031:TMED10
uniprot id: Q5ZIR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:FSHB
gene id: 9031:FSHB
uniprot id: Q8QGF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9031:SPON2
gene id: 9031:SPON2
uniprot id: A0A1D5PVD0
names: Subcellular Location Annotation
messages: extracellular matrix

9031:SFR1
gene id: 9031:SFR1
uniprot id: E1BXS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFR1/MEI5 family.
messages: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (By similarity). May act as a transcriptional modulator for ESR1 (By similarity).
messages: Component of the swi5-sfr1 complex.
messages: Nucleus

9031:AXL
gene id: 9031:AXL
uniprot id: Q98949
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autophosphorylated on tyrosine residues.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
messages: Cell membrane
messages: Detected in embryonic retina (at protein level). detected in brain, retina, kidney and in retinal Mueller glia-like cells.
messages: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, enhances PI3-kinase activity and activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes (By similarity).

9031:TNKS
gene id: 9031:TNKS
uniprot id: Q800D9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:TMEM184B
gene id: 9031:TMEM184B
uniprot id: Q5F3F0
names: Subcellular Location Annotation
messages: Membrane

9031:MRPS17
gene id: 9031:MRPS17
uniprot id: E1C9H4
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9031:KCNK10
gene id: 9031:KCNK10
uniprot id: F1NUZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9031:GORAB
gene id: 9031:GORAB
uniprot id: F1NUY6
names: Similarity
messages: Belongs to the GORAB family.

9031:ERG
gene id: 9031:ERG
uniprot id: A0A1D5P6W0
uniprot id: Q8UUU0
uniprot id: Q90837
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a transcriptional activator.
messages: Belongs to the ETS family.
messages: Expressed in mesoderm- and, to a lesser extent, in ectoderm-derived tissues.
messages: Nucleus

9031:ARHGDIB
gene id: 9031:ARHGDIB
uniprot id: F1NLT8
names: Similarity
messages: Belongs to the Rho GDI family.

9031:BMPR1B
gene id: 9031:BMPR1B
uniprot id: F1NTD3
uniprot id: Q05438
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcription (By similarity). Positively regulates chondrocyte differentiation (PubMed:24129431, PubMed:14523231).

9031:HOXB5
gene id: 9031:HOXB5
uniprot id: Q5I188
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9031:BORA
gene id: 9031:BORA
uniprot id: A0A3Q2U088
uniprot id: Q5F3S1
names: Similarity
messages: Belongs to the BORA family.

9031:PDCD10
gene id: 9031:PDCD10
uniprot id: Q5ZIV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development.

9031:RHBDF1
gene id: 9031:RHBDF1
uniprot id: A0A3Q3AKI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

9031:SLC6A4
gene id: 9031:SLC6A4
uniprot id: A0A8V1AK67
uniprot id: F1NZ44
uniprot id: Q6PWI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Synapse
messages: focal adhesion
messages: neuron projection

9031:GNGT2
gene id: 9031:GNGT2
uniprot id: A0A1D5PLZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9031:GNMT
gene id: 9031:GNMT
uniprot id: A0A8V0Z8I0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9031:DNTTIP1
gene id: 9031:DNTTIP1
uniprot id: A0A8V0YU04
names: Subcellular Location Annotation
messages: Nucleus

9031:PLAA
gene id: 9031:PLAA
uniprot id: A0A1L1RWJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9031:APIP
gene id: 9031:APIP
uniprot id: Q5ZLP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.
messages: Cytoplasm

9031:BTF3L4
gene id: 9031:BTF3L4
uniprot id: Q5ZJG3
names: Similarity
messages: Belongs to the NAC-beta family.

9031:PCK2
gene id: 9031:PCK2
uniprot id: P21642
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Appears to be constitutively expressed.
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver.
messages: In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one. In birds, PEPCK-M is the sole form of hepatic PEPCK, but it constitutes 60% of the enzyme in the kidney.
messages: Mitochondrion
messages: Monomer.
messages: Present in liver and kidney.

9031:ACSS1A
gene id: 9031:ACSS1A
uniprot id: F1NLR1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9031:POU4F1
gene id: 9031:POU4F1
uniprot id: A0A1D5P1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9031:L3MBTL3
gene id: 9031:L3MBTL3
uniprot id: A0A1D5PTN3
names: Subcellular Location Annotation
messages: Nucleus

9031:PMEPA1
gene id: 9031:PMEPA1
uniprot id: Q5ZJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9031:KHDRBS3
gene id: 9031:KHDRBS3
uniprot id: A0A1D5PBZ2
uniprot id: A0A8V0Y7U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDRBS family.
messages: Cytoplasm

9031:GALNT14
gene id: 9031:GALNT14
uniprot id: A0A8V0YU13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:GDF10
gene id: 9031:GDF10
uniprot id: A0A8V0ZGH5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9031:NDUFV3
gene id: 9031:NDUFV3
uniprot id: D5M8S6
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

9031:SARS1
gene id: 9031:SARS1
uniprot id: Q5ZM75
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9031:NEMP2
gene id: 9031:NEMP2
uniprot id: Q5ZJY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9031:ADSS2
gene id: 9031:ADSS2
uniprot id: Q5ZJL5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited competitively by AMP and IMP and non-competitively by fructose 1,6-bisphosphate.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

9031:DDX6
gene id: 9031:DDX6
uniprot id: Q5ZKB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
messages: Cytoplasm
messages: Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation.
messages: Nucleus
messages: P-body

9031:SDHD
gene id: 9031:SDHD
uniprot id: Q5ZIS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9031:RPL14
gene id: 9031:RPL14
uniprot id: A0A8V0YR80
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9031:IWS1
gene id: 9031:IWS1
uniprot id: E1BRQ9
names: Subcellular Location Annotation
messages: Nucleus

9031:ADGRD1
gene id: 9031:ADGRD1
uniprot id: A0A1D5P588
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:PBX3
gene id: 9031:PBX3
uniprot id: Q5ZLI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9031:PNRC1
gene id: 9031:PNRC1
uniprot id: Q5ZII5
names: Subcellular Location Annotation
messages: Nucleus

9031:DERL1
gene id: 9031:DERL1
uniprot id: Q5ZMF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9031:KAT2A
gene id: 9031:KAT2A
uniprot id: A0A8V0ZTT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9031:CLDN23
gene id: 9031:CLDN23
uniprot id: A0A1D5PZV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9031:GALR1
gene id: 9031:GALR1
uniprot id: B2ZE94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:PSPH
gene id: 9031:PSPH
uniprot id: E1C9F4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

9031:EED
gene id: 9031:EED
uniprot id: Q5ZKH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ESC family.
messages: Component of the PRC2/EED-EZH2 complex.
messages: Nucleus
messages: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity).

9031:BTD
gene id: 9031:BTD
uniprot id: E1C3J7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9031:DTX1
gene id: 9031:DTX1
uniprot id: A0A8V0X556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9031:GHR
gene id: 9031:GHR
uniprot id: F1N9U3
uniprot id: Q02092
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Broad specificity.
messages: Cell membrane
messages: Defects in GHR are a cause of sex-linked dwarf chicken. A restriction fragment length polymorphism, and an aberrantly-sized transcript in liver leads to a GHR with undetectable GH-binding activity causing growth deficiency and other endocrine abnormalities.
messages: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.
messages: On GH binding, proteolytically cleaved, in vitro, to produce GHBP.
messages: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.
messages: On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).
messages: Proteolytically cleaved, in vitro, to release the growth hormone-binding protein (GHBP).
messages: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
messages: The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

9031:ENDOG
gene id: 9031:ENDOG
uniprot id: A0A8V1A9K2
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9031:PDE4B
gene id: 9031:PDE4B
uniprot id: Q5ZKR6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:SF3B5
gene id: 9031:SF3B5
uniprot id: A0A1D5P7U7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9031:CNTN1
gene id: 9031:CNTN1
uniprot id: P14781
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. Contactin family.
messages: Cell membrane
messages: Interacts with TNR.
messages: Mediates cell surface interactions during nervous system development. Interaction with TNR enhances the neurite outgrowth.

9031:CYP1A1
gene id: 9031:CYP1A1
uniprot id: P79760
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:HMGB1
gene id: 9031:HMGB1
uniprot id: Q9YH06
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome
messages: Cytoplasm
messages: Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucleic acids. May promote inflammatory response to sterile and infectious signals and may be involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm may function as sensor and/or chaperone for immunogenic nucleic acids, and mediate autophagy. May act as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury.
messages: Nucleus
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).
messages: Secreted
messages: The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins; may involve Lys-3 and histone H3 'Lys-37' and 'Lys-38'.

9031:ETV1
gene id: 9031:ETV1
uniprot id: A0A8V0XBQ2
uniprot id: Q9YHW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:SYF2
gene id: 9031:SYF2
uniprot id: F1P0B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

9031:C11orf70
gene id: 9031:C11orf70
uniprot id: E1C9D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9031:PLK3
gene id: 9031:PLK3
uniprot id: A0A1D5P517
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9031:GFRA2
gene id: 9031:GFRA2
uniprot id: O13157
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (By similarity).

9031:MC4R
gene id: 9031:MC4R
uniprot id: Q6E6M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9031:TNFRSF1B
gene id: 9031:TNFRSF1B
uniprot id: Q5ZL08
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:FHL5
gene id: 9031:FHL5
uniprot id: E1C1I0
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9031:FLI1
gene id: 9031:FLI1
uniprot id: A0A8V0ZST3
uniprot id: Q5ZKX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:NQO1
gene id: 9031:NQO1
uniprot id: A0A8V0XZ95
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9031:LACC1
gene id: 9031:LACC1
uniprot id: A0A3Q2UAL7
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9031:SFRP2
gene id: 9031:SFRP2
uniprot id: Q9IA96
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: In embryo, expressed in developing neural structures as well as in heart, branchial arches and limb buds. First expressed at stage 7 in the neural plate with lower expression in the midline. By stage 9, expressed through out the developing neural tube with lower levels in the future posterior mesencephalon and rhombomere 3. In anterior regions, highest expression in the dorsal neural tube and, more posteriorly throughout the closing neural tube. Also expressed in the ectoderm flanking the neural tube. In the developing brain, expression found in the presumptive forbrain. By stage 12, expression restricted to the dorsal prosencephalon, hindbrain and posterior neural tube. In the placodes, first expressed at stage 11, in the otic placode. By stage 15, expressed in the olfactory and epibranchial placodes. In facial primordia, expression found at stage 2,0 throughout the ectoderm. By stage 24, high mesenchymal expression in a small region of the posterior maxillary primordia, and in the lateral region of the mandibular primordia. By stage 28, expressed in a subset of muscles, including the intermandibularis muscle and the muscle medial to the eye. In the developing trunk, expression found throughout the dermamyotome in the more developed somites. By stage 20, expression restricted to the small region in the dorsal medial lip in all somites. In addition, also expressed in the ventral lateral lip of the dermamyotome that gives rise to the muscles of the limbs and body wall. During limb development, expressed between stages 20 and 30, in the proximal mesenchyme in association with developing muscles. Between stages 27 and 30, expression found in mesenchyme containing undifferentiated myogenic cells. In the developing heart, expression restricted to the myocardial and endocardial cell layers of the trabeculae in the ventricular compartment between stages 20 and 28.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 appears to be associated with myogenesis.
messages: The FZ domain is involved in binding with Wnt ligands.

9031:WTAP
gene id: 9031:WTAP
uniprot id: A0A8V0XHC1
uniprot id: E1BV94
names: Similarity
messages: Belongs to the fl(2)d family.

9031:FABP9
gene id: 9031:FABP9
uniprot id: A0A1D5PJZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9031:TUBA8B
gene id: 9031:TUBA8B
uniprot id: P08070
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: Testis specific.
messages: The MREC motif may be critical for tubulin autoregulation.
messages: There are at least seven alpha tubulin genes (alpha-1 to alpha-6, and alpha-8), and a pseudogene (alpha-7) in chicken.
messages: This tubulin does not have a C-terminal tyrosine.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:B2M
gene id: 9031:B2M
uniprot id: P21611
uniprot id: Q6L753
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.
messages: Secreted

9031:MEPE
gene id: 9031:MEPE
uniprot id: F1NSM7
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Asn-62 is fully glycosylated, whereas only less than 10% of Asn-293 seem to be glycosylated.
messages: Belongs to the osteoregulin family.
messages: Expressed at high levels at the middle of the calcification stage of shell formation. Expression levels are similar at 3-4 hours post-oviposition prior to entry of the egg into the uterus and at 16-17 hours post-oviposition during eggshell calcification. Expressed in tibia from 5 dpc and in mandible from 7 dpc until the end of embryonic development at 19 dpc. Expression detected first in osteoblasts, in later stages both in osteoblasts and osteocytes, and by the end of embryonic development mainly in osteocytes.
messages: In the eggshell, expressed mainly in the palisade and mammillary layers. Expression also detected in the hypertrophic zone of the epiphyseal growth plate, and in cortical and medullary bone (at protein level). Highly expressed in uterus. Not detected in the proximal oviduct, liver, magnum, duodenum and kidney.
messages: Major component of the eggshell matrix. May play an important role in the regulation of calcite growth during eggshell calcification. May also regulate the mineralization process in developing and growing bones.
messages: extracellular matrix

9031:UMOD
gene id: 9031:UMOD
uniprot id: Q766V2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ATP2B4
gene id: 9031:ATP2B4
uniprot id: A0A1D5PJX0
uniprot id: A0A1D5PU07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:NETO1
gene id: 9031:NETO1
uniprot id: A0A1D5PQM2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:EPHB6
gene id: 9031:EPHB6
uniprot id: Q07497
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
messages: Membrane
messages: Most abundant in thymus and detectable in brain, retina, kidney, lung and heart. Not detected in skeletal muscle and liver.
messages: Receptor for members of the ephrin-B family.

9031:SLAIN2
gene id: 9031:SLAIN2
uniprot id: A0A3Q2U2B3
uniprot id: F1NZZ4
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9031:RFX3
gene id: 9031:RFX3
uniprot id: A0A3Q2UHK2
uniprot id: F1NC32
names: Subcellular Location Annotation
messages: Nucleus

9031:SLC1A7
gene id: 9031:SLC1A7
uniprot id: A0A8V1A904
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9031:SOX14
gene id: 9031:SOX14
uniprot id: Q9W7R6
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a negative regulator of transcription.
messages: Highly expressed in developing brain and spinal cord.
messages: Nucleus

9031:EIF5
gene id: 9031:EIF5
uniprot id: Q5ZIE0
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9031:HOXD11
gene id: 9031:HOXD11
uniprot id: A0A8V0ZUN5
uniprot id: P24342
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Coordinately expressed in partially overlapping domains during wing development.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:SOX4
gene id: 9031:SOX4
uniprot id: Q5J7B6
names: Subcellular Location Annotation
messages: Nucleus

9031:AK1
gene id: 9031:AK1
uniprot id: P05081
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (PubMed:2161682, PubMed:2229026, PubMed:2542324, PubMed:1958702). Exhibits nucleoside diphosphate kinase catalyzing the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and dTTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor (By similarity). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (PubMed:2229026, PubMed:8431472).
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Skeletal muscle.

9031:PHF20
gene id: 9031:PHF20
uniprot id: A0A8V0ZFL3
uniprot id: A0A8V0ZTD9
uniprot id: E1BRX7
names: Subcellular Location Annotation
messages: Nucleus

9031:LIN9
gene id: 9031:LIN9
uniprot id: Q5ZMF8
names: Similarity
messages: Belongs to the lin-9 family.

9031:ATAD1
gene id: 9031:ATAD1
uniprot id: F1NT80
names: Similarity
messages: Belongs to the AAA ATPase family.

9031:PPP2R2B
gene id: 9031:PPP2R2B
uniprot id: A0A1D5PC44
uniprot id: A0A1D5PWQ5
uniprot id: F1NS72
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9031:ART1L3
gene id: 9031:ART1L3
uniprot id: P55807
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.
messages: extracellular space

9031:BRIX1
gene id: 9031:BRIX1
uniprot id: Q5ZLV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9031:CPSF2
gene id: 9031:CPSF2
uniprot id: F1NMN0
uniprot id: Q5F3I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9031:ATP6V1G3
gene id: 9031:ATP6V1G3
uniprot id: A0A1D5P6L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9031:MPPE1
gene id: 9031:MPPE1
uniprot id: Q5ZK82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Binds 2 manganese ions per subunit.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity).
messages: cis-Golgi network membrane

9031:MRPS33
gene id: 9031:MRPS33
uniprot id: R4GM73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9031:MICAL2
gene id: 9031:MICAL2
uniprot id: A0A8V0ZNK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9031:DCAF1
gene id: 9031:DCAF1
uniprot id: A0A1D5PF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

9031:CAPRIN1
gene id: 9031:CAPRIN1
uniprot id: Q5XNV3
names: Similarity
messages: Belongs to the caprin family.

9031:VAC14
gene id: 9031:VAC14
uniprot id: Q5ZIW5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities. Interacts with NOS1.
messages: Microsome membrane
messages: Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
messages: The C-terminal domain (residues 523-782) mediates pentameric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex.

9031:IFNA3
gene id: 9031:IFNA3
uniprot id: P42165
uniprot id: Q38IF1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears first at 3 hours post-infection, increases to give the strongest signal at about 9 hours and gradually wanes to almost nothing at 24 hours.
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:SV2B
gene id: 9031:SV2B
uniprot id: A0A1D5PW37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9031:HTR6
gene id: 9031:HTR6
uniprot id: D2XUT1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:TEF
gene id: 9031:TEF
uniprot id: Q92172
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. PAR subfamily.
messages: Binds DNA as a homodimer or a heterodimer. Exists as a stable dimer in the absence of DNA.
messages: Isoform 1 and isoform 3 are expressed in a variety of somatic tissues, including liver, heart, intestine, stomach and kidney. Both isoforms are also expressed in hepatoma (LMH) cells and in embryonic fibroblast cell lines. Isoform 2 and isoform 4 are expressed in adult heart and intestine.
messages: Isoform 3 is expressed as early as embryonic day 10.
messages: Nucleus
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform 1.
messages: Produced by alternative splicing of isoform 2.
messages: Transcription factor that binds to and transactivates the vitellogenin II (VTG2) promoter. Binds to the palindromic sequence 5'-GTTTACATAAAC-3'.

9031:EEF1B2
gene id: 9031:EEF1B2
uniprot id: Q9YGQ1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
messages: Phosphorylation affects the GDP/GTP exchange rate.

9031:TTC27
gene id: 9031:TTC27
uniprot id: Q5F3K0
names: Similarity
messages: Belongs to the TTC27 family.

9031:GHRHR
gene id: 9031:GHRHR
uniprot id: Q1PCF1
uniprot id: Q309X7
names: Subcellular Location Annotation
messages: Membrane

9031:SCAMP3
gene id: 9031:SCAMP3
uniprot id: A0A8V1AII1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9031:CAB39
gene id: 9031:CAB39
uniprot id: R4GI86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9031:TSEN2
gene id: 9031:TSEN2
uniprot id: Q5ZIN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity).
messages: Nucleus
messages: tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34/LENG5 and SEN54.

9031:PDS5A
gene id: 9031:PDS5A
uniprot id: Q5F3V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDS5 family.
messages: Interacts with the cohesin complex. Binds chromatin in a cohesin-dependent manner (By similarity).
messages: May regulate sister chromatid cohesion during mitosis and couple it to DNA replication.
messages: Nucleus

9031:HIST1H2B7L4
gene id: 9031:HIST1H2B7L4
uniprot id: P0C1H3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct.
messages: Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:TNFSF15
gene id: 9031:TNFSF15
uniprot id: Q50L61
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9031:S100A12
gene id: 9031:S100A12
uniprot id: P28318
names: Similarity
names: Tissue Specificity
messages: Belongs to the S-100 family.
messages: Expressed in v-myb-transformed myelomonocytic cells.

9031:MYF6
gene id: 9031:MYF6
uniprot id: C4P6Q1
uniprot id: Q01795
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
messages: Nucleus
messages: Skeletal muscle.

9031:RIF1
gene id: 9031:RIF1
uniprot id: E1C2U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIF1 family.
messages: Chromosome
messages: Interacts with TP53BP1 (when phosphorylated by ATM).
messages: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:23333306). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).
messages: Nucleus
messages: spindle
messages: telomere

9031:HIF1A
gene id: 9031:HIF1A
uniprot id: Q9YIB9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID) (By similarity).
messages: Cytoplasm
messages: Efficient DNA binding requires heterodimerization of an alpha and a beta/ARNT subunit.
messages: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
messages: In normoxia, is hydroxylated on Asn-788, thus abrogating interaction with CREBBP and EP300 and preventing transcriptional activation.
messages: In normoxia, is hydroxylated on Pro-402 and Pro-562. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (By similarity).
messages: Induced by reactive oxygen species (ROS).
messages: Nucleus
messages: Nucleus speckle
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.

9031:PNPLA7
gene id: 9031:PNPLA7
uniprot id: B3TZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:EDC4
gene id: 9031:EDC4
uniprot id: A0A1D5P1Q3
uniprot id: A0A1D5PW21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9031:DGKB
gene id: 9031:DGKB
uniprot id: A0A1D5PLX8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9031:PRDX6
gene id: 9031:PRDX6
uniprot id: Q5ZJF4
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration (By similarity).
messages: Irreversibly inactivated by overoxidation of Cys-46 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress.
messages: Lysosome
messages: Phosphorylation at Thr-176 by MAP kinases increases the phospholipase activity of the enzyme (By similarity). The phosphorylated form exhibits a greater lysophosphatidylcholine acyltransferase activity compared to the non-phosphorylated form (By similarity).
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) is reactivated by glutathionylation mediated by glutathione S-transferase Pi, followed by spontaneous reduction of the enzyme with glutathione.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity).

9031:PRSS3
gene id: 9031:PRSS3
uniprot id: Q90627
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: High levels are seen in the pancreas while lower levels are found in the liver, spleen and thymus.
messages: extracellular space

9031:STX19
gene id: 9031:STX19
uniprot id: E1C6K1
names: Similarity
messages: Belongs to the syntaxin family.

9031:SLC16A9
gene id: 9031:SLC16A9
uniprot id: Q5ZJU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter. Functions also as a pH-independent carnitine efflux transporter.

9031:FTH1
gene id: 9031:FTH1
uniprot id: P08267
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferritin family.
messages: Cytoplasm
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.

9031:MAEA
gene id: 9031:MAEA
uniprot id: Q5F398
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity).
messages: Cytoplasm
messages: Identified in the CTLH complex that contains at least MAEA, RMND5A, GID8, WDR26, and RANBP9 and/or RANBP10 as the catalytic core. Interacts with F-actin.
messages: Nucleus matrix
messages: The expected RING-type zinc finger domain is highly divergent and most of the expected Cys residues are not conserved. Still, the protein is required for CTLH complex E3 ubiquitin-protein transferase activity. In addition, the conserved Cys-314 in this highly divergent region is required for ubiquitination by the yeast GID complex, suggesting a direct role in catalyzing ubiquitination.
messages: cytoskeleton
messages: nucleoplasm

9031:ADGRF4
gene id: 9031:ADGRF4
uniprot id: A0A3Q2UI82
names: Subcellular Location Annotation
messages: Membrane

9031:UBE3A
gene id: 9031:UBE3A
uniprot id: A0A1D5PTI9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9031:VPS41
gene id: 9031:VPS41
uniprot id: A0A1D5PZF2
uniprot id: Q5ZL70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9031:UTP11
gene id: 9031:UTP11
uniprot id: E1BU24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9031:MAP2K5
gene id: 9031:MAP2K5
uniprot id: A0A8V0YZ74
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:EIF3H
gene id: 9031:EIF3H
uniprot id: Q5ZLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

9031:BLCAP
gene id: 9031:BLCAP
uniprot id: A0A3Q3ANJ1
names: Similarity
messages: Belongs to the BLCAP family.

9031:RPL29
gene id: 9031:RPL29
uniprot id: A0A1L1RNZ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9031:HOXD13
gene id: 9031:HOXD13
uniprot id: P24344
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Coordinately expressed in partially overlapping domains during wing development.
messages: Nucleus
messages: Sequence-specific transcription factor that binds gene promoters and activates their transcription (By similarity). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (PubMed:1672266).

9031:SDR42E1
gene id: 9031:SDR42E1
uniprot id: A0A8V0Y0K1
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9031:MBL2
gene id: 9031:MBL2
uniprot id: Q98TA4
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.
messages: In contrast to mammals, which contain two copies of MBL (MBL1 and MBL2), chicken genome only contains one copy of MBL.
messages: Oligomeric complex of 3 or more homotrimers.
messages: Secreted

9031:DCN
gene id: 9031:DCN
uniprot id: P28675
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, to fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN (By similarity).
messages: May affect the rate of fibrils formation.
messages: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
messages: extracellular matrix

9031:LOC422609
gene id: 9031:LOC422609
uniprot id: A0A1D5P2I2
uniprot id: A0A8V0XNW5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9031:PUS7
gene id: 9031:PUS7
uniprot id: A0A8V0Y5Y2
uniprot id: F1NCJ9
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9031:EIF3L
gene id: 9031:EIF3L
uniprot id: Q5F428
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

9031:SNCA
gene id: 9031:SNCA
uniprot id: Q9I9H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse

9031:CTNNB1
gene id: 9031:CTNNB1
uniprot id: A0A1D5PQN0
uniprot id: O42486
names: Similarity
messages: Belongs to the beta-catenin family.

9031:C11orf1
gene id: 9031:C11orf1
uniprot id: A0A8V1A480
names: Function
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.

9031:CTPS1
gene id: 9031:CTPS1
uniprot id: A0A1D5PSR2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9031:BCL2L1
gene id: 9031:BCL2L1
uniprot id: Q07816
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Bcl-2 family.
messages: Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).
messages: Highest expression in organs with lymphoid development.
messages: Mitochondrion matrix
messages: Mitochondrion membrane
messages: Nucleus membrane
messages: The BH4 motif seems to be involved in the anti-apoptotic function. Intact BH1 and BH2 motifs are required for anti-apoptotic activity (By similarity).
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9031:ADK
gene id: 9031:ADK
uniprot id: A0A1D5NZY6
uniprot id: Q5ZMK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9031:ALB
gene id: 9031:ALB
uniprot id: A0A8V0XJ14
names: Subcellular Location Annotation
messages: Secreted

9031:MPPED2
gene id: 9031:MPPED2
uniprot id: E1BXB8
names: Similarity
messages: Belongs to the UPF0046 family.

9031:DICER1
gene id: 9031:DICER1
uniprot id: Q25BN1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. Dicer subfamily.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. Note that the trimeric RLC/miRLC is also referred to as RISC (By similarity).
messages: Cytoplasm
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity).
messages: It is uncertain whether Met-1 or Met-11 is the initiator.

9031:IFT20
gene id: 9031:IFT20
uniprot id: A0A8V1ADP5
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9031:LAMTOR2
gene id: 9031:LAMTOR2
uniprot id: A0A8V1AEX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9031:OVALY
gene id: 9031:OVALY
uniprot id: I0J178
uniprot id: P01014
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: Down-regulated by dietary stress. Decreased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens.
messages: Major protein of egg white (PubMed:25436390, PubMed:16428832). Expressed in the magnum of the oviduct (at protein level) (PubMed:25436390).
messages: N-glycosylated on at least two Asn residues by ovomucoid type carbohydrate units.
messages: Secreted
messages: The N-terminus is blocked.

9031:FGF1
gene id: 9031:FGF1
uniprot id: A0A2L2DDN9
uniprot id: P19596
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9031:NFE2L2
gene id: 9031:NFE2L2
uniprot id: Q90834
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9031:PAX6
gene id: 9031:PAX6
uniprot id: O42348
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9031:HIST2H3A
gene id: 9031:HIST2H3A
uniprot id: P84229
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

9031:UPF2
gene id: 9031:UPF2
uniprot id: A0A8V0XT80
names: Subcellular Location Annotation
messages: Cytoplasm

9031:HAND1
gene id: 9031:HAND1
uniprot id: Q90691
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: At stage 8, detected in the cardiac crescent. At stage 10, expressed throughout the cardiac tube and the sinus venosus. By stage 15, expressed homogeneously in the various regions of the heart, including the atria, future left ventricle, bulbus cordis and truncus arteriosus, and in the forming branchial arches. Expression persists through stage 20, but decreases thereafter.
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Transcription factor (By similarity). Plays an essential role in cardiac morphogenesis (PubMed:8533092).
messages: nucleolus
messages: nucleoplasm

9031:PKNOX1
gene id: 9031:PKNOX1
uniprot id: E1BYI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9031:GART
gene id: 9031:GART
uniprot id: A0A547
uniprot id: P21872
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Binds 1 magnesium or manganese ion per subunit.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.
messages: The C-terminal GART domain carries the phosphoribosylglycinamide formyltransferase activity.
messages: The N-terminal ATP-grasp domain carries the phosphoribosylamine--glycine ligase activity.
messages: The central AIRS domain carries the phosphoribosylformylglycinamidine cyclo-ligase activity.
messages: Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway.

9031:KIF3B
gene id: 9031:KIF3B
uniprot id: A0A8V0YJY7
uniprot id: Q5F423
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:PIK3IP1
gene id: 9031:PIK3IP1
uniprot id: A0A8V0ZS63
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CLCC1
gene id: 9031:CLCC1
uniprot id: F1P073
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane

9031:SF3B6
gene id: 9031:SF3B6
uniprot id: A0A8V0Y6V5
names: Subcellular Location Annotation
messages: Nucleus

9031:CORO2A
gene id: 9031:CORO2A
uniprot id: A0A8V0XNL2
names: Similarity
messages: Belongs to the WD repeat coronin family.

9031:GATC
gene id: 9031:GATC
uniprot id: A0A8V0ZHK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9031:ZEB1
gene id: 9031:ZEB1
uniprot id: A0A2D3HKK9
uniprot id: P36197
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a transcriptional repressor. Positively regulates neuronal differentiation. Represses transcription by binding to the E box-containing promoter. Binds to delta 1-crystallin enhancer core and represses lens-specific transcription (PubMed:7904558). It also binds many other non-lens specific DNA sequences (PubMed:7904558).
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
messages: Expression is developmentally regulated with high expression in mesoderm, nervous system and lens.
messages: Expression starts after gastrulation, when organogenesis has just begun.
messages: Nucleus

9031:ELOVL5
gene id: 9031:ELOVL5
uniprot id: A0A8V0X898
uniprot id: E3VVZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: dendrite

9031:PTHLH
gene id: 9031:PTHLH
uniprot id: A0A8V0ZL24
uniprot id: P17251
uniprot id: Q5TLZ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity).

9031:XKR7
gene id: 9031:XKR7
uniprot id: A0A8V0YSZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9031:SMN
gene id: 9031:SMN
uniprot id: Q98SU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body
messages: Perikaryon
messages: Z line
messages: gem
messages: neuron projection

9031:BSG
gene id: 9031:BSG
uniprot id: P17790
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Brain endothelial cells, kidney epithelial cells and erythroblasts (at protein level).
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687).
messages: Interacts with NXNL1, SLC2A1 and SLC16A1.
messages: N-glycosylated.
messages: Photoreceptor inner segment
messages: Retinal cone photoreceptors (at protein level).
messages: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (By similarity). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity).
messages: photoreceptor outer segment

9031:LOC107057554
gene id: 9031:LOC107057554
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:QARS
gene id: 9031:QARS
uniprot id: Q5F3C0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9031:SEMA6D
gene id: 9031:SEMA6D
uniprot id: A0A1D5PMF8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GATA2
gene id: 9031:GATA2
uniprot id: A0A8V1AC24
uniprot id: P23824
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in all developmental stages of erythroid cells but is additionally found in a limited subset of other tissues.
messages: Nucleus
messages: Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.

9031:EIF5B
gene id: 9031:EIF5B
uniprot id: E1BVP1
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

9031:TNNT2
gene id: 9031:TNNT2
uniprot id: P02642
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9031:MCM4
gene id: 9031:MCM4
uniprot id: E1C2U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9031:IRX1
gene id: 9031:IRX1
uniprot id: Q9I9C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9031:STMN3
gene id: 9031:STMN3
uniprot id: O93388
names: Similarity
messages: Belongs to the stathmin family.

9031:MAPK8IP3
gene id: 9031:MAPK8IP3
uniprot id: A0A8V0YW32
names: Similarity
messages: Belongs to the JIP scaffold family.

9031:TSPAN15
gene id: 9031:TSPAN15
uniprot id: Q5ZJ30
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:GFI1B
gene id: 9031:GFI1B
uniprot id: O42409
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
messages: Expressed in erythroid cells of primitive and definitive lineage and bone marrow cells.
messages: Nucleus
messages: The zinc finger domain is essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain.

9031:BLOC1S6
gene id: 9031:BLOC1S6
uniprot id: Q5ZIM2
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9031:CDH13
gene id: 9031:CDH13
uniprot id: P33150
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Neural tissues. Also found in muscles; kidney and retina.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:IK
gene id: 9031:IK
uniprot id: Q5ZHM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9031:MED7
gene id: 9031:MED7
uniprot id: E1C6N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9031:HRH1
gene id: 9031:HRH1
uniprot id: F1NEN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:MUSTN1
gene id: 9031:MUSTN1
uniprot id: Q76MS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: May be involved in the development and regeneration of the musculoskeletal system.
messages: Nucleus

9031:NADK
gene id: 9031:NADK
uniprot id: A0A1D5PVT8
uniprot id: Q5F3R0
names: Similarity
messages: Belongs to the NAD kinase family.

9031:GPD1L2
gene id: 9031:GPD1L2
uniprot id: A0A3Q2TX12
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9031:EXOSC9
gene id: 9031:EXOSC9
uniprot id: Q6B7Z6
names: Subcellular Location Annotation
messages: Cytoplasm

9031:FGF3
gene id: 9031:FGF3
uniprot id: P48801
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.
messages: Secreted

9031:ASTL
gene id: 9031:ASTL
uniprot id: P0DJJ2
names: Cofactor
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cortical granule
messages: Cytoplasm
messages: Expressed in embryonic stem cells. Expressed in the pluripotent cells of the epiblast. Detected at the junction of non-neuronal and neuronal ectoderm just before neural tube closure. Expressed in the ventral epidermis before ventral closure, in the intermediate mesoderm, gonads and the forming nephric duct and tubules of the mesonephros and metanephros.
messages: Expressed in ovary and gonads.
messages: Probable oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. May act as a protease (By similarity).

9031:ERRFI1
gene id: 9031:ERRFI1
uniprot id: E1C8Y8
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9031:ACAP2
gene id: 9031:ACAP2
uniprot id: Q5ZK62
names: Activity Regulation
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).

9031:STMN2
gene id: 9031:STMN2
uniprot id: Q90987
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Expression is neuron-specific and found in cerebellum, forebrain, midbrain, tectum and spinal cord.
messages: Is a key regulator of neurite extension through regulation of microtubule instabilily.
messages: Membrane
messages: axon
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9031:ENTPD2
gene id: 9031:ENTPD2
uniprot id: A0A1D5PS27
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9031:PDIA4
gene id: 9031:PDIA4
uniprot id: Q5ZK20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9031:GPR137B
gene id: 9031:GPR137B
uniprot id: Q5ZLT1
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9031:GNPDA2
gene id: 9031:GNPDA2
uniprot id: E1C878
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9031:PRDM12
gene id: 9031:PRDM12
uniprot id: E1C6K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

9031:CA8
gene id: 9031:CA8
uniprot id: A0A1D5PPM5
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9031:LBH
gene id: 9031:LBH
uniprot id: Q5ZM46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9031:KHDRBS1
gene id: 9031:KHDRBS1
uniprot id: Q8UUW7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Positively correlates with ability to bind RNA (By similarity).
messages: Belongs to the KHDRBS family.
messages: Cytoplasm
messages: Membrane
messages: Methylated by HRMT1L2. Required for nuclear localization (By similarity).
messages: Nucleus
messages: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion.
messages: Self-associates to form homooligomers when bound to RNA, oligomerization appears to be limited when binding to proteins.
messages: The KH domain is required for binding to RNA.
messages: Tyrosine phosphorylated by several non-receptor tyrosine kinases including LCK, FYN and JAK3.

9031:TMPRSS2
gene id: 9031:TMPRSS2
uniprot id: F1NY88
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:RPL6
gene id: 9031:RPL6
uniprot id: Q8UWG7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9031:SLC35A1
gene id: 9031:SLC35A1
uniprot id: Q8AW01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:WFDC1
gene id: 9031:WFDC1
uniprot id: Q8JG33
names: Function
names: Subcellular Location Annotation
messages: Has growth inhibitory activity.
messages: Secreted

9031:UGCG
gene id: 9031:UGCG
uniprot id: E1C7A5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9031:HAPLN1
gene id: 9031:HAPLN1
uniprot id: P07354
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAPLN family.
messages: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
messages: extracellular matrix

9031:EMC6
gene id: 9031:EMC6
uniprot id: A0A1L1RMS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:GPX8
gene id: 9031:GPX8
uniprot id: R4GGB2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9031:HAT1
gene id: 9031:HAT1
uniprot id: Q9DFS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9031:ELK3
gene id: 9031:ELK3
uniprot id: Q5ZMM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:CSK
gene id: 9031:CSK
uniprot id: P41239
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
messages: Cytoplasm
messages: Homodimer (via SH3-domain).
messages: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs). Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane (By similarity).
messages: Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated (By similarity).
messages: The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.

9031:PRL
gene id: 9031:PRL
uniprot id: A0A0B5KZ08
uniprot id: P14676
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9031:NEDD9
gene id: 9031:NEDD9
uniprot id: A0A3Q2TVN1
uniprot id: F1NW90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9031:LOC426913
gene id: 9031:LOC426913
uniprot id: R4GKP9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:NPY4R
gene id: 9031:NPY4R
uniprot id: Q8QGM3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:XPOT
gene id: 9031:XPOT
uniprot id: E1C593
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9031:TMEM167A
gene id: 9031:TMEM167A
uniprot id: Q5ZII6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.

9031:BET1L
gene id: 9031:BET1L
uniprot id: F1P2A4
uniprot id: Q5ZLZ4
names: Subcellular Location Annotation
messages: Membrane

9031:TSPAN13
gene id: 9031:TSPAN13
uniprot id: A0A1D5P7Y2
uniprot id: A0A1D5PPC9
names: Subcellular Location Annotation
messages: Membrane

9031:NDUFS3
gene id: 9031:NDUFS3
uniprot id: F1ND23
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

9031:CLTCL1
gene id: 9031:CLTCL1
uniprot id: A0A1D5PAU8
uniprot id: A0A8V1A986
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9031:CCL5
gene id: 9031:CCL5
uniprot id: Q8QG57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:RACK1
gene id: 9031:RACK1
uniprot id: E6N1V8
uniprot id: P63247
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity).
messages: Nucleus
messages: Perikaryon
messages: dendrite
messages: perinuclear region

9031:UFM1
gene id: 9031:UFM1
uniprot id: Q5ZMK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UFM1 family.
messages: Cytoplasm
messages: Interacts with UBA5. Interacts with UFC1.
messages: Nucleus
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9031:TWSG1
gene id: 9031:TWSG1
uniprot id: Q98T89
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the twisted gastrulation protein family.
messages: Interacts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7 (By similarity).
messages: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
messages: Secreted
messages: The N-terminal domain is sufficient to interact with BMP4.

9031:HMBOX1
gene id: 9031:HMBOX1
uniprot id: A0A8V0Y7V0
uniprot id: E1BZ53
names: Subcellular Location Annotation
messages: Nucleus

9031:ADAM17
gene id: 9031:ADAM17
uniprot id: Q5ZL93
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:LOC426218
gene id: 9031:LOC426218
uniprot id: H9L096
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:EVC
gene id: 9031:EVC
uniprot id: Q670Z8
names: Subcellular Location Annotation
messages: Membrane
messages: cilium basal body
messages: cilium membrane

9031:GJB2
gene id: 9031:GJB2
uniprot id: E1C2J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:RGS20
gene id: 9031:RGS20
uniprot id: Q9PWA1
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).
messages: Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity).
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
messages: Membrane
messages: N- and O-glycosylated in synapsomal membranes.
messages: Nucleus
messages: Sumoylated by SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).

9031:FOS
gene id: 9031:FOS
uniprot id: P11939
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Fos subfamily.
messages: Endoplasmic reticulum
messages: Expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.
messages: Heterodimer. Interacts with MAFB.
messages: May be Tyr-phosphorylated in quiescent cells and dephosphorylated upon cell growth induction.
messages: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity).
messages: Nucleus
messages: cytosol

9031:TUBGCP2
gene id: 9031:TUBGCP2
uniprot id: Q5ZKY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9031:MYBPHL
gene id: 9031:MYBPHL
uniprot id: Q05623
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. MyBP family.
messages: Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
messages: Skeletal muscle. Seems to be also expressed in the slow tonic ald muscle. Not detected in gizzard or heart.

9031:SAMHD1
gene id: 9031:SAMHD1
uniprot id: Q5ZJL9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated and regulated via the combined actions of GTP and dNTPs (dATP, dGTP, dTTP and dCTP): Allosteric site 1 binds GTP, while allosteric site 2 binds dNTP. Allosteric activation promotes the formation of highly active homotetramers.
messages: Belongs to the SAMHD1 family.
messages: Binds 1 zinc ion per subunit.
messages: Chromosome
messages: Homodimer; in absence of GTP and dNTP. Homotetramer; in GTP- and dNTP-bound form (By similarity). Interacts with rbbp8/CtIP (By similarity).
messages: Nucleus
messages: Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication. Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation. Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity.

9031:CNN2
gene id: 9031:CNN2
uniprot id: Q5ZKU6
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9031:GLCE
gene id: 9031:GLCE
uniprot id: A0A8V0Z2Q6
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9031:THADA
gene id: 9031:THADA
uniprot id: A8C754
names: Function
names: Similarity
messages: Belongs to the THADA family.
messages: Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.

9031:MFSD7
gene id: 9031:MFSD7
uniprot id: F1ND71
names: Subcellular Location Annotation
messages: Membrane

9031:MDM2
gene id: 9031:MDM2
uniprot id: F1NGX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9031:SEC61A2
gene id: 9031:SEC61A2
uniprot id: A0A1D5NXC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:CDC6
gene id: 9031:CDC6
uniprot id: A0A3Q2TYA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9031:HBE1
gene id: 9031:HBE1
uniprot id: Q90864
names: Similarity
messages: Belongs to the globin family.

9031:NR4A2
gene id: 9031:NR4A2
uniprot id: A0A1D5NYR5
uniprot id: E1C6K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Nucleus

9031:MRPS36
gene id: 9031:MRPS36
uniprot id: F1N8U1
names: Subcellular Location Annotation
messages: Mitochondrion

9031:SOHO1
gene id: 9031:SOHO1
uniprot id: Q91964
names: Subcellular Location Annotation
messages: Nucleus

9031:SNAP91
gene id: 9031:SNAP91
uniprot id: Q5ZLX6
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9031:ARL8A
gene id: 9031:ARL8A
uniprot id: Q5ZKQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity).
messages: Synapse
messages: axon
messages: spindle

9031:PGA3
gene id: 9031:PGA3
uniprot id: P16476
names: Developmental Stage
names: Similarity
messages: Belongs to the peptidase A1 family.
messages: Specifically secreted during the embryonic period in the chicken proventriculus (glandular stomach).

9031:PDCL
gene id: 9031:PDCL
uniprot id: E1BQM7
names: Similarity
messages: Belongs to the phosducin family.

9031:CER1
gene id: 9031:CER1
uniprot id: Q9PUK2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:TXLNG
gene id: 9031:TXLNG
uniprot id: F1NI14
uniprot id: V9GWR2
names: Similarity
messages: Belongs to the taxilin family.

9031:MKNK2
gene id: 9031:MKNK2
uniprot id: A0A8V1ADT4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:RECQL
gene id: 9031:RECQL
uniprot id: F1NPI7
uniprot id: Q8AYS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9031:TOB1
gene id: 9031:TOB1
uniprot id: Q90VW0
names: Similarity
messages: Belongs to the BTG family.

9031:CELF2
gene id: 9031:CELF2
uniprot id: Q7T2T1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Expressed in heart at embryonic day 12 and 14 (at protein level). Expressed in heart at embryonic day 8.
messages: Expressed in heart.
messages: Nucleus
messages: RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation repression and stability. Mediates exon inclusion in TNNT2 pre-mRNA.

9031:NFYA
gene id: 9031:NFYA
uniprot id: A0A8V1A4Z1
uniprot id: A0A8V1AH79
uniprot id: Q5ZMH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9031:HSF3
gene id: 9031:HSF3
uniprot id: A0A1D5PS43
uniprot id: P38531
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HSF family.
messages: Cytoplasm
messages: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF3 binds DNA constitutively only when the C-terminal region is deleted.
messages: Expressed during development.
messages: Expressed in most tissues. High levels are found in erythrocytes and low levels in liver.
messages: Homotrimer.
messages: Nucleus

9031:PTDSS1
gene id: 9031:PTDSS1
uniprot id: Q5ZM65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
messages: Endoplasmic reticulum membrane

9031:IL4I1
gene id: 9031:IL4I1
uniprot id: E6N1V0
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9031:EEF2
gene id: 9031:EEF2
uniprot id: Q90705
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Binds to 80S ribosomes (By similarity). Actively translating ribosomes show mutually exclusive binding of eIF5a (EIF5A or EIF5A2) and EEF2/eEF2 (By similarity). Interacts with SERBP1; interaction sequesters EEF2/eEF2 at the A-site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation (By similarity). Interacts with HABP4; interaction takes place at the A-site of hibernating ribosomes and promotes ribosome stabilization (By similarity).
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm
messages: Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine (By similarity).
messages: Nucleus
messages: Phosphorylation by EF-2 kinase completely inactivates EF-2.

9031:RBM3
gene id: 9031:RBM3
uniprot id: Q45KQ2
uniprot id: Q5ZLU8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm

9031:PDIA2
gene id: 9031:PDIA2
uniprot id: A0A1D5PKM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9031:TMEM170B
gene id: 9031:TMEM170B
uniprot id: A0A8V0Y5X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9031:NDUFA8
gene id: 9031:NDUFA8
uniprot id: A0A1D5P3K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9031:TMLHE
gene id: 9031:TMLHE
uniprot id: Q5F4B3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gamma-BBH/TMLD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
messages: Homodimer.
messages: Mitochondrion matrix

9031:STX7
gene id: 9031:STX7
uniprot id: Q5ZMP2
names: Similarity
messages: Belongs to the syntaxin family.

9031:ACTB
gene id: 9031:ACTB
uniprot id: P60706
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylation at His-73 by SETD3 (PubMed:30626964). Methylation stabilizes actin filaments (PubMed:11955010).
messages: N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP.
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (By similarity). Each actin can bind to 4 others (By similarity).
messages: cytoskeleton

9031:TMED2
gene id: 9031:TMED2
uniprot id: Q5ZKB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9031:NUF2
gene id: 9031:NUF2
uniprot id: A0A140T8H9
uniprot id: Q76I90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12829748). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (By similarity). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity).
messages: Belongs to the NUF2 family.
messages: Component of the NDC80 complex, which is composed of at least NDC80/HEC1 and CDCA1.
messages: Cytoplasm
messages: Nucleus
messages: centrosome
messages: kinetochore

9031:SMIM8
gene id: 9031:SMIM8
uniprot id: F1P1R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9031:GRIA2
gene id: 9031:GRIA2
uniprot id: Q90728
uniprot id: Q90856
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:RAP1GDS1
gene id: 9031:RAP1GDS1
uniprot id: Q5ZL86
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion

9031:RAD1
gene id: 9031:RAD1
uniprot id: A0A1D5PSK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9031:CDO1
gene id: 9031:CDO1
uniprot id: E1C9J4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9031:MIXL1
gene id: 9031:MIXL1
uniprot id: O73592
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Expressed early in embryogenis in a sickle-shaped area in the posterior zone of the blastoderm. With the beginning of gastrulation, it is found in the primitive streak primordium, then in the young and medium-sized streak, however not in the mesoderm after its emergence. In the fully-extended streak, it is restricted to its middle, i.e. the prospective ventral mesoderm. It is then undetectable by in later stages.
messages: Nucleus
messages: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood (By similarity).

9031:ITGA6
gene id: 9031:ITGA6
uniprot id: P26007
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha-6 levels decrease with age.
messages: Belongs to the integrin alpha chain family.
messages: Cell membrane
messages: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 (ITGB1) or beta-4 (ITGB4) to form ITGA6:ITGB1 and ITGA6:ITGB4, respectively.
messages: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
messages: Phosphorylated in vivo.

9031:CLU
gene id: 9031:CLU
uniprot id: Q9YGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol

9031:LDLRAD4
gene id: 9031:LDLRAD4
uniprot id: E1BYM2
uniprot id: F6RPR8
uniprot id: Q5ZJR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9031:SLC9A9
gene id: 9031:SLC9A9
uniprot id: Q5F3I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Recycling endosome membrane

9031:EMX1
gene id: 9031:EMX1
uniprot id: A0A1D5PI40
names: Subcellular Location Annotation
messages: Nucleus

9031:SEMA3D
gene id: 9031:SEMA3D
uniprot id: Q90663
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Developing spinal cord and developing visual system. Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.
messages: Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin.
messages: Secreted
messages: Strong binding to neuropilin is mediated by the carboxy third of the protein.

9031:ITFG1
gene id: 9031:ITFG1
uniprot id: Q5ZL76
names: Similarity
messages: Belongs to the TIP family.

9031:TMSB15B
gene id: 9031:TMSB15B
uniprot id: Q0GFE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9031:ABHD2
gene id: 9031:ABHD2
uniprot id: F1P1V6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9031:RPS14
gene id: 9031:RPS14
uniprot id: Q5ZHW8
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9031:SLBP
gene id: 9031:SLBP
uniprot id: Q6B7Z7
names: Similarity
messages: Belongs to the SLBP family.

9031:MARCKS
gene id: 9031:MARCKS
uniprot id: P16527
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MARCKS family.
messages: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
messages: Membrane
messages: cytoskeleton

9031:ZIC1
gene id: 9031:ZIC1
uniprot id: A0A1D5PND2
uniprot id: Q8JJC0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Expressed in dorsal undifferentiated neural cells in the spinal cord at stages 8 and 23 (at protein level). Expressed in the dorsal neural tube along almost the entire rostrocaudal extent and dorsomedial somites at stage 8. Expressed in the dorsal hindbrain, spinal cord, midbrain and forebrain at stage 17. Expressed in somites and the dorsal CNS at stage 23.
messages: Nucleus

9031:SNX8
gene id: 9031:SNX8
uniprot id: A0A3Q2U5T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9031:NPBWR2
gene id: 9031:NPBWR2
uniprot id: A0A172PX08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:CSRNP1
gene id: 9031:CSRNP1
uniprot id: A0A8V1A8R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9031:HINT2
gene id: 9031:HINT2
uniprot id: Q9I882
names: Similarity
messages: Belongs to the HINT family.

9031:VAPB
gene id: 9031:VAPB
uniprot id: Q5ZJJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:BCR
gene id: 9031:BCR
uniprot id: E1C0M5
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9031:SLC29A1
gene id: 9031:SLC29A1
uniprot id: A0A8V0ZHI1
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9031:CD3E
gene id: 9031:CD3E
uniprot id: P70069
names: Subcellular Location Annotation
messages: Membrane

9031:RAX2
gene id: 9031:RAX2
uniprot id: Q9PVY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus
messages: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.

9031:CORO1C
gene id: 9031:CORO1C
uniprot id: Q5ZI60
names: Similarity
messages: Belongs to the WD repeat coronin family.

9031:B4GALT1
gene id: 9031:B4GALT1
uniprot id: Q92074
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:NFIA
gene id: 9031:NFIA
uniprot id: Q90925
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9031:CRH
gene id: 9031:CRH
uniprot id: Q703P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9031:RAB6A
gene id: 9031:RAB6A
uniprot id: Q1KME6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Golgi apparatus membrane
messages: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER.

9031:CREG1
gene id: 9031:CREG1
uniprot id: Q5ZJ73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: May contribute to the transcriptional control of cell growth and differentiation.
messages: Secreted

9031:LOC419080
gene id: 9031:LOC419080
uniprot id: A0A8V0X985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:MRPS30
gene id: 9031:MRPS30
uniprot id: O42270
names: Subcellular Location Annotation
messages: Mitochondrion

9031:VANGL2
gene id: 9031:VANGL2
uniprot id: A0A8V1AFD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9031:AvBD1
gene id: 9031:AvBD1
uniprot id: P46156
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Detected in the theca layer of the ovarian follicle in the white follicle (WF) stage, but decreases throughout the F1, F3, F5, and postovulatory follicle stages. Detected in the granulosa layer of the ovarian follicle in the white follicle (WF) stage, F1, F3, F5, and postovulatory follicle stages. In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens.
messages: Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans.
messages: Induced in the theca layer of the F3 stage ovarian follicle by intravenous injection of LPS. Repressed in the granulosa layer of the F3 stage ovarian follicle by intravenous injection of LPS. Expression in cultured vaginal cells is increased by LPS and S.enteritidis. Expression in the kidney and liver is not affected by intravenous injection of LPS.
messages: Secreted
messages: Strong expression in the bone marrow, lung, testis. Moderate expression in the bursa and intestine. Low expression in the cloaca, gall bladder, brain and pancreas. Expressed in the vagina, ovarian stroma and the theca and granulosa layers of the ovarian follicle.

9031:PTH
gene id: 9031:PTH
uniprot id: A9YX65
uniprot id: P15743
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.
messages: Secreted

9031:LHFPL1
gene id: 9031:LHFPL1
uniprot id: E1BUW2
names: Subcellular Location Annotation
messages: Membrane

9031:HIST2H4B
gene id: 9031:HIST2H4B
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:SLC39A3
gene id: 9031:SLC39A3
uniprot id: A0A3Q2U760
names: Subcellular Location Annotation
messages: Membrane

9031:SLC13A2
gene id: 9031:SLC13A2
uniprot id: A0A8V1AM47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9031:ASCC1
gene id: 9031:ASCC1
uniprot id: A0A1D5PKQ5
names: Subcellular Location Annotation
messages: Cytoplasm

9031:HTR1A
gene id: 9031:HTR1A
uniprot id: D2K8P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:GDA
gene id: 9031:GDA
uniprot id: A0A3Q2UHG8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9031:NUP42
gene id: 9031:NUP42
uniprot id: Q5ZI22
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus membrane
messages: Probable component of the nuclear pore complex (NPC).
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.
messages: The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.
messages: nuclear pore complex

9031:CD151
gene id: 9031:CD151
uniprot id: Q5ZII8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:ZC2HC1C
gene id: 9031:ZC2HC1C
uniprot id: F1NAH9
names: Similarity
messages: Belongs to the ZC2HC1 family.

9031:MFSD2A
gene id: 9031:MFSD2A
uniprot id: F1NCD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (By similarity). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity).

9031:DPYSL3
gene id: 9031:DPYSL3
uniprot id: A0A1D5PZ51
uniprot id: Q71SF8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9031:HTR7
gene id: 9031:HTR7
uniprot id: A0A8V0ZDC6
uniprot id: D4P5A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:ATG5
gene id: 9031:ATG5
uniprot id: F7AY48
uniprot id: Q5ZHW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9031:ADIPOR2
gene id: 9031:ADIPOR2
uniprot id: Q5ZMH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9031:RGN
gene id: 9031:RGN
uniprot id: Q9I923
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+).
messages: Cytoplasm
messages: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).

9031:COPS3
gene id: 9031:COPS3
uniprot id: Q5ZJF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN3 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Component of the CSN complex, probably composed of COPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7, COPS8 and COPS9.
messages: Cytoplasm
messages: Nucleus

9031:EDNRB2
gene id: 9031:EDNRB2
uniprot id: A0A3Q2UCL4
uniprot id: Q8JHV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:LSM7
gene id: 9031:LSM7
uniprot id: Q5ZL52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9031:CDH7
gene id: 9031:CDH7
uniprot id: Q90763
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
messages: Cell membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:SLC9A3R1
gene id: 9031:SLC9A3R1
uniprot id: Q5ZM14
names: Function
names: Subcellular Location Annotation
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. May enhance Wnt signaling (By similarity).
messages: filopodium
messages: microvillus
messages: ruffle

9031:UBAC1
gene id: 9031:UBAC1
uniprot id: Q5ZJI9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the KPC complex.
messages: Cytoplasm
messages: Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1. Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome.
messages: The UBA domains recognize and bind polyubiquitinated proteins.

9031:PPP1R14C
gene id: 9031:PPP1R14C
uniprot id: A0A1D5PUM3
uniprot id: A0A8V0XI66
names: Similarity
messages: Belongs to the PP1 inhibitor family.

9031:MYL1
gene id: 9031:MYL1
uniprot id: P02604
uniprot id: P02605
names: PTM
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: The N-terminus is blocked.
messages: The N-terminus is blocked. N,N,N-trimethylalanine, found in other myosin light chains would not have been detected in the N-terminal tryptic peptide in PubMed:6709041 and PubMed:7238855 because it would remain trimethylated and ninhydrin negative after hydrolysis.

9031:CORO2B
gene id: 9031:CORO2B
uniprot id: A0A3Q3AYV8
uniprot id: E1C2B6
names: Similarity
messages: Belongs to the WD repeat coronin family.

9031:MYO1G
gene id: 9031:MYO1G
uniprot id: Q5ZMC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cell membrane
messages: Interacts with calmodulin; via its IQ motifs.
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).
messages: Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication.
messages: phagocytic cup

9031:SUCLA2
gene id: 9031:SUCLA2
uniprot id: Q5F3B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9031:FOSL2
gene id: 9031:FOSL2
uniprot id: P18625
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Fos subfamily.
messages: Heterodimer with JUN.
messages: Nucleus
messages: Serum inducible, and cycloheximide superinducible.

9031:YIPF3
gene id: 9031:YIPF3
uniprot id: Q5F384
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity).
messages: cis-Golgi network membrane

9031:SLC2A11L5
gene id: 9031:SLC2A11L5
uniprot id: A0A3Q2UNR7
uniprot id: A0A8V0ZYA9
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:ERCC3
gene id: 9031:ERCC3
uniprot id: F1NZ23
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9031:FOXL2
gene id: 9031:FOXL2
uniprot id: Q5J7N5
names: Subcellular Location Annotation
messages: Nucleus

9031:VWC2L
gene id: 9031:VWC2L
uniprot id: E1BSM6
names: Subcellular Location Annotation
messages: Synapse

9031:ARL8BL
gene id: 9031:ARL8BL
uniprot id: A0A1D5NTX3
uniprot id: Q5ZKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9031:CASD1
gene id: 9031:CASD1
uniprot id: A0A8V0XJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

9031:LOC428499
gene id: 9031:LOC428499
uniprot id: A0A1D5NWC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9031:AVPR2
gene id: 9031:AVPR2
uniprot id: Q9PTN7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:FUCA2
gene id: 9031:FUCA2
uniprot id: E1BS94
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9031:GGACT
gene id: 9031:GGACT
uniprot id: A0A3Q2U3N8
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9031:RPS10
gene id: 9031:RPS10
uniprot id: E1C4N0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9031:MSRB3
gene id: 9031:MSRB3
uniprot id: R4GI10
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9031:XRCC4
gene id: 9031:XRCC4
uniprot id: F1NDC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

9031:DYL1
gene id: 9031:DYL1
uniprot id: Q5F412
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9031:PSD2
gene id: 9031:PSD2
uniprot id: A0A1D5P0H4
uniprot id: A0A8V0YJM9
names: Subcellular Location Annotation
messages: ruffle membrane

9031:SCP2
gene id: 9031:SCP2
uniprot id: Q07598
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A 10-fold increase in expression levels is seen by 1 week post-hatch and declines slightly between 3 and 4 weeks post-hatch.
messages: Contains a putative mitochondrial transit peptide at positions 1-20.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Expressed at high levels in the liver, intestine and ovarian granulosa cells.
messages: In the N-terminal section; belongs to the thiolase-like superfamily. Thiolase family.
messages: Levels remain unchanged during day 20 embryo to 4 weeks post-hatch.
messages: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity).
messages: Mitochondrion
messages: Peroxisome
messages: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (By similarity). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity).
messages: preSCP2, a protein with a molecular mass of about 15 kDa, is processed into its mature form (SCP2) by proteolytic cleavage of a 20 residue leader sequence after translocation into peroxisomes.

9031:LHX2
gene id: 9031:LHX2
uniprot id: O42108
names: Subcellular Location Annotation
messages: Nucleus

9031:CDPF1
gene id: 9031:CDPF1
uniprot id: Q5ZKB8
names: Similarity
messages: Belongs to the CDPF1 family.

9031:HSPB3
gene id: 9031:HSPB3
uniprot id: A0A3Q2TSR2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

9031:FIBIN
gene id: 9031:FIBIN
uniprot id: E1BX99
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9031:CHUK
gene id: 9031:CHUK
uniprot id: Q5ZJB4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated when phosphorylated and inactivated when dephosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

9031:NDUFAF2
gene id: 9031:NDUFAF2
uniprot id: R4GHM9
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9031:GRID1
gene id: 9031:GRID1
uniprot id: A0A8V0Y0B5
uniprot id: A0A8V0Y0C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:NR2E1
gene id: 9031:NR2E1
uniprot id: Q91379
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Expressed exclusively in the neuroepithelium of the embryonic brain.
messages: Monomer.
messages: Nucleus
messages: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation (By similarity). Involved in the regulation of retinal development.

9031:FUBP3
gene id: 9031:FUBP3
uniprot id: A0A3Q2TU83
uniprot id: A0A3Q3AB26
uniprot id: Q5ZM76
names: Subcellular Location Annotation
messages: Cytoplasm

9031:SLC40A1
gene id: 9031:SLC40A1
uniprot id: Q5F3K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lateral cell membrane
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

9031:BRD1
gene id: 9031:BRD1
uniprot id: A0A3Q2U221
names: Subcellular Location Annotation
messages: Nucleus

9031:DRAM1
gene id: 9031:DRAM1
uniprot id: E1BYC9
names: Subcellular Location Annotation
messages: Membrane

9031:DPT
gene id: 9031:DPT
uniprot id: A0A1D5NVS3
names: Similarity
messages: Belongs to the dermatopontin family.

9031:CD47
gene id: 9031:CD47
uniprot id: A0A8V0XHV1
uniprot id: Q5ZL65
uniprot id: Q6XFR0
uniprot id: Q6XFR1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:FZR1
gene id: 9031:FZR1
uniprot id: H9L1Y1
uniprot id: Q8UWJ7
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9031:CMTR1
gene id: 9031:CMTR1
uniprot id: A0A8V0ZDM0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

9031:SCARB1
gene id: 9031:SCARB1
uniprot id: A0A1D5PMI6
uniprot id: A0A3Q2TTF7
uniprot id: A0A8V0ZGQ0
uniprot id: F1NAN9
names: Similarity
messages: Belongs to the CD36 family.

9031:LOC418421
gene id: 9031:LOC418421
uniprot id: A0A8V0XH91
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:KIF2A
gene id: 9031:KIF2A
uniprot id: A0A1D5PBU5
uniprot id: Q5ZKV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
messages: Cytoplasm
messages: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity).
messages: centrosome
messages: spindle
messages: spindle pole

9031:RPS6KB1
gene id: 9031:RPS6KB1
uniprot id: Q5ZLW5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9031:BCHE
gene id: 9031:BCHE
uniprot id: Q90ZK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9031:SLC10A2
gene id: 9031:SLC10A2
uniprot id: A0A3S5ZP78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9031:F10
gene id: 9031:F10
uniprot id: P25155
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. VAP cleaves the fusion proteins of Sendai virus, NDV, and influenza virus a at a specific single arginine-containing site, and plays a key role in the viral spreading in the allantoic sac.
messages: Liver and chorioallantoic membrane.
messages: Secreted
messages: The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
messages: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds.
messages: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.

9031:CAMK2A
gene id: 9031:CAMK2A
uniprot id: O93559
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9031:GDNF
gene id: 9031:GDNF
uniprot id: A0A8V0YHD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9031:NUP205
gene id: 9031:NUP205
uniprot id: E1BV83
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

9031:SEPSECS
gene id: 9031:SEPSECS
uniprot id: Q5F3Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9031:ADCY9
gene id: 9031:ADCY9
uniprot id: A0A1L1RTJ6
uniprot id: F1NP57
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9031:PCDHA4
gene id: 9031:PCDHA4
uniprot id: Q6R0I7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:FOXD2
gene id: 9031:FOXD2
uniprot id: P79770
names: Subcellular Location Annotation
messages: Nucleus

9031:COLEC10
gene id: 9031:COLEC10
uniprot id: Q2LK95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the COLEC10/COLEC11 family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration.
messages: Secreted
messages: Widely expressed. Highly expressed in lung. Weakly expressed in larynx, syrinx and cranial air sac. Expressed throughout the lower gastrointestinal tract in increasing levels starting from a faint signal in duodenum and ending with relatively high signals in proctodeum, coprodeum and urodeum. In the upper part of the gastrointestinal tract, expressed in tongue, crop, and mucosa of the crop.

9031:A4GALT
gene id: 9031:A4GALT
uniprot id: E1C034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9031:SMC2
gene id: 9031:SMC2
uniprot id: Q90988
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
messages: Chromosome
messages: Cytoplasm
messages: Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and probably some non SMC subunits that regulate the complex.
messages: Nucleus
messages: The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.

9031:CTBPL
gene id: 9031:CTBPL
uniprot id: Q5ZMM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9031:CALD1
gene id: 9031:CALD1
uniprot id: P12957
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping.
messages: Belongs to the caldesmon family.
messages: High-molecular-weight caldesmon (h-caldesmon) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (l-caldesmon) is widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
messages: Phosphorylated in non-muscle cells. Phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization (By similarity).
messages: The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the muscle forms.
messages: cytoskeleton
messages: myofibril
messages: stress fiber

9031:KRR1
gene id: 9031:KRR1
uniprot id: Q5ZKE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

9031:PPP6R3
gene id: 9031:PPP6R3
uniprot id: A0A8V1ABS4
uniprot id: Q5F471
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SAPS family.
messages: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).
messages: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit (By similarity).

9031:PSEN1
gene id: 9031:PSEN1
uniprot id: A0A3Q2UE42
uniprot id: Q4JIM4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.
messages: Cell membrane
messages: Cytoplasmic granule
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by a caspase.
messages: Homodimer.
messages: Homodimer. The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity (By similarity). Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment (By similarity). Interacts with CDH2 (PubMed:16046145).
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Substrates, such as NOTCH1 and APP peptides, are bound between PSEN1 transmembrane domains and via the first lumenal loop and the cytoplasmic loop between the sixth and seventh transmembrane domains. Substrate binding causes a conformation change and formation of an intermolecular antiparallel beta-sheet between PSEN1 and its substrates.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9031:GALNT6
gene id: 9031:GALNT6
uniprot id: Q5F4C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:GUSB
gene id: 9031:GUSB
uniprot id: A0A1L1RSD2
uniprot id: Q5ZIA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Lysosome

9031:WEE1
gene id: 9031:WEE1
uniprot id: Q5F400
uniprot id: R4GJW5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

9031:PTPRB
gene id: 9031:PTPRB
uniprot id: A0A8V0YIN5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9031:MGAT5B
gene id: 9031:MGAT5B
uniprot id: A0A8V1AHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:C2orf88
gene id: 9031:C2orf88
uniprot id: A0A1D5PFG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

9031:STEAP3
gene id: 9031:STEAP3
uniprot id: A0A1D5P106
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9031:CTU2
gene id: 9031:CTU2
uniprot id: A0A3Q2U523
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9031:IGF2R
gene id: 9031:IGF2R
uniprot id: Q90681
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TUBB2B
gene id: 9031:TUBB2B
uniprot id: P32882
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Highly expressed in neuronal cells.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:NRAS
gene id: 9031:NRAS
uniprot id: Q5F352
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

9031:SOD1
gene id: 9031:SOD1
uniprot id: P80566
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.
messages: Nucleus

9031:DIP2B
gene id: 9031:DIP2B
uniprot id: A0A3Q2U035
uniprot id: A0A8V0ZHV5
names: Similarity
messages: Belongs to the DIP2 family.

9031:PLCG2
gene id: 9031:PLCG2
uniprot id: A0A1D5PHP4
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9031:FGF6
gene id: 9031:FGF6
uniprot id: F1P5Y5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:QRFPR
gene id: 9031:QRFPR
uniprot id: B2CL09
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:AFF3
gene id: 9031:AFF3
uniprot id: A0A8V0YTP1
names: Similarity
messages: Belongs to the AF4 family.

9031:ASCC3
gene id: 9031:ASCC3
uniprot id: F1NTD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes.
messages: Belongs to the helicase family.
messages: Nucleus
messages: Nucleus speckle
messages: cytosol

9031:CHRNB4
gene id: 9031:CHRNB4
uniprot id: Q7T3Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:MYD88
gene id: 9031:MYD88
uniprot id: A5HNF6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
messages: Cytoplasm
messages: Expressed in spleen, liver, kidney, bursa of Fabricius, lung and brain (at protein level). Expressed in cecum, heart, spleen, liver, kidney, female reproductive tract, thymus, bursa of Fabricius, muscle and lung.
messages: Nucleus
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.

9031:FAM228
gene id: 9031:FAM228
uniprot id: A0A1L1RWM1
names: Similarity
messages: Belongs to the FAM228 family.

9031:RIC8B
gene id: 9031:RIC8B
uniprot id: A0A1D5PF61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

9031:SLC4A7
gene id: 9031:SLC4A7
uniprot id: A0A3Q2UMA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

9031:CBFA2T3
gene id: 9031:CBFA2T3
uniprot id: Q5F3B1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBFA2T family.
messages: Expressed in the spinal cord of stage 22 embryos. Expressed during neurogenesis in the mantle zone of the spinal cord in domains corresponding to interneurons.
messages: Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein (By similarity).
messages: Golgi apparatus
messages: nucleolus
messages: nucleoplasm

9031:SCAMP2
gene id: 9031:SCAMP2
uniprot id: F1NV32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9031:F2
gene id: 9031:F2
uniprot id: Q91001
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

9031:CPS1
gene id: 9031:CPS1
uniprot id: Q5KTI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GRIN1
gene id: 9031:GRIN1
uniprot id: A0A3Q2U5F6
uniprot id: A0A8V1AJ32
uniprot id: Q6R6I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:TMEM70
gene id: 9031:TMEM70
uniprot id: Q5ZLJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM70 family.
messages: Mitochondrion inner membrane
messages: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1. Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis.

9031:NONO
gene id: 9031:NONO
uniprot id: A0A8V0YZ19
uniprot id: Q5ZIZ5
names: Subcellular Location Annotation
messages: Nucleus speckle

9031:PPP6C
gene id: 9031:PPP6C
uniprot id: Q5ZIV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9031:F11R
gene id: 9031:F11R
uniprot id: A1E345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9031:AARS1
gene id: 9031:AARS1
uniprot id: F1P5J5
uniprot id: Q5ZKF3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9031:ECHDC2
gene id: 9031:ECHDC2
uniprot id: F1NSS6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9031:LOC107057539
gene id: 9031:LOC107057539
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:SFRP5
gene id: 9031:SFRP5
uniprot id: A0A0K0PVD8
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PDGFRL
gene id: 9031:PDGFRL
uniprot id: E1C836
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.

9031:YIPF4
gene id: 9031:YIPF4
uniprot id: Q5ZJD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Involved in the maintenance of the Golgi structure.
messages: cis-Golgi network membrane

9031:INTS13
gene id: 9031:INTS13
uniprot id: A0A8V0YPL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

9031:ANXA2
gene id: 9031:ANXA2
uniprot id: A0A1C9KD18
uniprot id: P17785
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
messages: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.
messages: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
messages: Membrane
messages: basement membrane

9031:MIOS
gene id: 9031:MIOS
uniprot id: F1NS24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9031:NMNAT2
gene id: 9031:NMNAT2
uniprot id: E1BXJ1
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9031:HIST1H2B5
gene id: 9031:HIST1H2B5
uniprot id: P0C1H4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:NR2F2
gene id: 9031:NR2F2
uniprot id: Q90733
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Binds DNA as a homodimer.
messages: Highly expressed in the developing spinal motor neurons.
messages: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development.
messages: Nucleus

9031:COPS4
gene id: 9031:COPS4
uniprot id: Q5ZJV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9031:KCNG4
gene id: 9031:KCNG4
uniprot id: E1BQU8
names: Subcellular Location Annotation
messages: Membrane

9031:SLC16A1
gene id: 9031:SLC16A1
uniprot id: Q5ZLZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9031:NRG1
gene id: 9031:NRG1
uniprot id: Q05199
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Contains an Ig-like domain.
messages: Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses (PubMed:8453670, PubMed:9491987). Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity).
messages: ERBB receptor binding is elicited entirely by the EGF-like domain.
messages: Extensive glycosylation precedes the proteolytic cleavage.
messages: Isoform 2-isoform 4 are detected at embryonic day 4 (ED4) in both visceral and somatic motor neurons of spinal cord and is highest at ED6. Isoform 1 is not expressed until ED 6 in spinal cord. At ED 11 both isoforms display comparable levels.
messages: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
messages: Secreted
messages: The EGF-like domain is replaced by a cysteine-rich domain (CRD).
messages: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).

9031:PIK3AP1
gene id: 9031:PIK3AP1
uniprot id: Q9DDT2
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Constitutively phosphorylated (By similarity). Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation.
messages: Cytoplasm
messages: Homooligomer (By similarity). Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase.
messages: It is unsure whether this isoform is produced by alternative splicing or alternative initiation.
messages: Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
messages: The DBB domain is required for dimerization.

9031:YWHAZ
gene id: 9031:YWHAZ
uniprot id: Q5ZKC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer.

9031:MLF1
gene id: 9031:MLF1
uniprot id: A0A1D5PNX1
uniprot id: A0A1L1RRD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9031:AADACL4B
gene id: 9031:AADACL4B
uniprot id: A0A8V0ZH66
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9031:WRB
gene id: 9031:WRB
uniprot id: F6R8U4
uniprot id: Q5ZJM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:CUTC
gene id: 9031:CUTC
uniprot id: Q5ZKA1
names: Similarity
messages: Belongs to the CutC family.

9031:IFNL3A
gene id: 9031:IFNL3A
uniprot id: A0A8V0YKJ0
uniprot id: B4ER10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Cytokine which plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exhibits antiviral activity against the H5N1 influenza A virus. Induces the expression of the antiviral MX protein in epithelial-rich tissues, such as intestine, trachea and lung.
messages: Secreted

9031:SMARCA2
gene id: 9031:SMARCA2
uniprot id: Q90755
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9031:KLHL40
gene id: 9031:KLHL40
uniprot id: A0A8V1ABP8
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

9031:KCNG3
gene id: 9031:KCNG3
uniprot id: A0A8V0ZD61
names: Subcellular Location Annotation
messages: Membrane

9031:OXCT1
gene id: 9031:OXCT1
uniprot id: Q5F3M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9031:MED4
gene id: 9031:MED4
uniprot id: A0A1D5P8W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:AP1G1
gene id: 9031:AP1G1
uniprot id: F1NDA9
uniprot id: Q5ZJ83
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9031:CASP8
gene id: 9031:CASP8
uniprot id: Q90WU1
names: Similarity
messages: Belongs to the peptidase C14A family.

9031:NPAS2
gene id: 9031:NPAS2
uniprot id: Q5ZQU2
names: Activity Regulation
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Carbon monoxide (CO) and the redox state of the cell can modulate the transcriptional activity of the NPAS2-BMAL1 heterodimer. NADH and NADPH enhance the DNA-binding activity of the heterodimer whereas CO binds the heme group in NPAS2 and inhibits the DNA-binding activity of the heterodimer.
messages: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with BMAL1 and this heterodimerization is required for E-box-dependent transactivation.
messages: Exhibits a circadian rhythm in the retina with peak levels in early subjective night. No circadian rhythm pattern in the pineal gland.
messages: Expressed in the retinal photoreceptor cells (at protein level). Expressed in the pineal gland and retina.
messages: Nucleus
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …

9031:IPO11
gene id: 9031:IPO11
uniprot id: A0A8V0YBZ9
names: Subcellular Location Annotation
messages: Cytoplasm

9031:MBOAT2
gene id: 9031:MBOAT2
uniprot id: Q5ZKL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. May catalyze preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Prefers oleoyl-CoA as the acyl donor.
messages: Belongs to the membrane-bound acyltransferase family.
messages: Endoplasmic reticulum
messages: Membrane

9031:AP5M1
gene id: 9031:AP5M1
uniprot id: A0A8V0Z1H8
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9031:C11orf58
gene id: 9031:C11orf58
uniprot id: Q9I9J6
names: Developmental Stage
names: Similarity
names: Tissue Specificity
messages: Belongs to the SMAP family.
messages: Expressed in brain, heart, eye, liver, kidney and skeletal muscle.
messages: Expressed in embryos at 2, 4 and 6 dpc.

9031:HMGN2P46
gene id: 9031:HMGN2P46
uniprot id: Q5ZIR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9031:SRPX2
gene id: 9031:SRPX2
uniprot id: A0A3Q2U607
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SH3GL2
gene id: 9031:SH3GL2
uniprot id: Q8AXV1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface (By similarity).
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Early endosome
messages: Highly expressed in brain.
messages: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
messages: Membrane
messages: Monomer; in cytoplasm. Homodimer; when associated with membranes. Associates with MAP4K3. This interaction appears to regulate MAP4K3-mediated JNK activation (By similarity). Interacts with SYNJ1 and DNM1.
messages: Presynapse

9031:SLC33A1
gene id: 9031:SLC33A1
uniprot id: A0A8V0X6L4
names: Subcellular Location Annotation
messages: Membrane

9031:CEP19
gene id: 9031:CEP19
uniprot id: A0A8V0ZZU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9031:TNNC1
gene id: 9031:TNNC1
uniprot id: P09860
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the troponin C family.
messages: Slow skeletal muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.
messages: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

9031:CELF4
gene id: 9031:CELF4
uniprot id: A0A8V0YAN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

9031:CDH8
gene id: 9031:CDH8
uniprot id: A6YJX2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

9031:ATP5F1AZ
gene id: 9031:ATP5F1AZ
uniprot id: Q8UVX3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9031:YWHAQ
gene id: 9031:YWHAQ
uniprot id: Q5ZMD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.

9031:GPR180
gene id: 9031:GPR180
uniprot id: A0A8V0XNV0
names: Subcellular Location Annotation
messages: Membrane

9031:HOXD3
gene id: 9031:HOXD3
uniprot id: E1BZG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9031:IL17F
gene id: 9031:IL17F
uniprot id: F1NFI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9031:KCNJ2
gene id: 9031:KCNJ2
uniprot id: P52186
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Found in the apical basilar papilla of the inner ear, brain, muscle, cerebellum, heart and liver.
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3, resulting in an enhanced G-protein-induced current. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).
messages: Membrane
messages: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

9031:PNPT1
gene id: 9031:PNPT1
uniprot id: A0A1D5NZ09
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

9031:HOXA4
gene id: 9031:HOXA4
uniprot id: P17277
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
messages: The proline stretch works as a part of the transcriptional activation domain.

9031:ARHGDIA
gene id: 9031:ARHGDIA
uniprot id: F1P3P3
uniprot id: Q5ZMT1
names: Similarity
messages: Belongs to the Rho GDI family.

9031:HACD3
gene id: 9031:HACD3
uniprot id: Q5ZM57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Involved in Rac1-signaling pathways leading to the modulation of gene expression.
messages: Endoplasmic reticulum membrane
messages: Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity.

9031:C4BPG
gene id: 9031:C4BPG
uniprot id: Q4AEI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:KPNA3
gene id: 9031:KPNA3
uniprot id: C6KIB2
names: Similarity
messages: Belongs to the importin alpha family.

9031:SKP1
gene id: 9031:SKP1
uniprot id: Q5ZKF5
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).

9031:CBWD1
gene id: 9031:CBWD1
uniprot id: Q5ZK54
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9031:TMTC4
gene id: 9031:TMTC4
uniprot id: A0A8V0XFN4
uniprot id: F1P0M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9031:TMEM150C
gene id: 9031:TMEM150C
uniprot id: A0A3Q2TW69
names: Subcellular Location Annotation
messages: Membrane

9031:MMP16
gene id: 9031:MMP16
uniprot id: A0A1D5PZ77
uniprot id: Q1EQ66
uniprot id: Q98947
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9031:PLA2G4F
gene id: 9031:PLA2G4F
uniprot id: A0A8V0ZL36
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9031:RGS7BP
gene id: 9031:RGS7BP
uniprot id: A0A8V0YCI7
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9031:S100A11
gene id: 9031:S100A11
uniprot id: P24479
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the S-100 family.
messages: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.
messages: Homodimer; disulfide-linked.
messages: Smooth muscle and non-muscle tissues.

9031:RHOT1
gene id: 9031:RHOT1
uniprot id: A0A8V1ADZ7
uniprot id: Q5ZM73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
messages: Mitochondrion outer membrane

9031:KCTD20
gene id: 9031:KCTD20
uniprot id: A0A1D5PY88
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ERCC4
gene id: 9031:ERCC4
uniprot id: V5Y0M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9031:SLC44A1
gene id: 9031:SLC44A1
uniprot id: A0A3Q2U280
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9031:RFT1
gene id: 9031:RFT1
uniprot id: A0A8V1AJA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

9031:LOC428144
gene id: 9031:LOC428144
uniprot id: A0A4P9IVJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9031:AMACR
gene id: 9031:AMACR
uniprot id: Q5ZL63
names: Similarity
messages: Belongs to the CoA-transferase III family.

9031:EXOC5
gene id: 9031:EXOC5
uniprot id: A0A8V0YTI3
uniprot id: Q5F3N2
names: Similarity
messages: Belongs to the SEC10 family.

9031:UNC45A
gene id: 9031:UNC45A
uniprot id: A0A1D5P9T4
names: Subcellular Location Annotation
messages: perinuclear region

9031:MCM2
gene id: 9031:MCM2
uniprot id: Q5ZLZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

9031:DLX3
gene id: 9031:DLX3
uniprot id: Q9PT89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9031:LOC101749502
gene id: 9031:LOC101749502
uniprot id: A0A1L1S0V0
names: Subcellular Location Annotation
messages: Secreted

9031:RXFP1
gene id: 9031:RXFP1
uniprot id: F1NY48
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:PSMD1
gene id: 9031:PSMD1
uniprot id: Q5F418
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD1. Interacts with ADRM1.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9031:SNRNP27
gene id: 9031:SNRNP27
uniprot id: E1BYM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9031:KRT23
gene id: 9031:KRT23
uniprot id: A0A1D5PQ65
names: Similarity
messages: Belongs to the intermediate filament family.

9031:EDNRB
gene id: 9031:EDNRB
uniprot id: A0A7L4W6L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:SMAD9
gene id: 9031:SMAD9
uniprot id: Q56I98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9031:AMFR
gene id: 9031:AMFR
uniprot id: F1NBB7
names: Subcellular Location Annotation
messages: Membrane

9031:EXFABP
gene id: 9031:EXFABP
uniprot id: P21760
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Developmentally regulated in chick embryo.
messages: Does not seem to be glycosylated.
messages: Down-regulated by dietary stress. Significantly decreased expression between days 0 to 5 in egg whites of eggs laid by corticosterone-fed hens (at protein level). Decreased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens.
messages: Expressed in egg white (at protein level). Expressed in the magnum of the oviduct (at protein level) (PubMed:25436390). Preferentially synthesized in nonproliferating cells.
messages: Monomer.
messages: Secreted
messages: Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor.

9031:LOC107057537
gene id: 9031:LOC107057537
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:CUEDC2
gene id: 9031:CUEDC2
uniprot id: A0A1D5P910
uniprot id: E1C7R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9031:STRADA
gene id: 9031:STRADA
uniprot id: A0A1D5PQK3
uniprot id: F1NL91
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9031:PHOX2B
gene id: 9031:PHOX2B
uniprot id: F1NMR6
names: Subcellular Location Annotation
messages: Nucleus

9031:STRN
gene id: 9031:STRN
uniprot id: A0A8V0XUY6
uniprot id: A0A8V0Y0R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9031:ATP1B1
gene id: 9031:ATP1B1
uniprot id: P08251
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

9031:HOXC10
gene id: 9031:HOXC10
uniprot id: A0A1D5PP81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9031:CDK9
gene id: 9031:CDK9
uniprot id: Q5ZKN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with cyclin-T to form P-TEFb. Also associates with cyclin-K (By similarity).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro (By similarity).
messages: Nucleus

9031:PIP5K1B
gene id: 9031:PIP5K1B
uniprot id: Q5ZJ58
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity).
messages: Cell membrane
messages: Endomembrane system
messages: cytosol

9031:NSFL1C
gene id: 9031:NSFL1C
uniprot id: Q5ZK10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSFL1C family.
messages: Golgi stack
messages: Nucleus
messages: Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
messages: centrosome

9031:CDK14
gene id: 9031:CDK14
uniprot id: A0A3Q2U2B1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:TMEM97
gene id: 9031:TMEM97
uniprot id: F1N859
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM97/sigma-2 receptor family.
messages: Endoplasmic reticulum membrane
messages: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

9031:AGPS
gene id: 9031:AGPS
uniprot id: A0A8V0ZXE3
uniprot id: F1P5J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
messages: Homodimer.
messages: Peroxisome

9031:CD99
gene id: 9031:CD99
uniprot id: A0A3Q3A7M3
names: Similarity
messages: Belongs to the CD99 family.

9031:MSX1
gene id: 9031:MSX1
uniprot id: P50223
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Msh homeobox family.
messages: Early limb development. First present in an asymmetric arc extending from the anterior border of the limb bud to the mesenchymal cells directly adjacent to the AER. Later abundantly expressed in the proximal anterior periphery and in the mid-proximal region of the posterior periphery. In older wing buds, detectable throughout the necrotic mesenchyme between the developing digits.
messages: Nucleus
messages: Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death.

9031:SLC4A3
gene id: 9031:SLC4A3
uniprot id: E1C314
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Membrane

9031:COL6A2
gene id: 9031:COL6A2
uniprot id: P15988
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type VI collagen family.
messages: Collagen VI acts as a cell-binding protein.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: Trimers composed of three different chains: alpha 1(VI), alpha 2(VI), and alpha 3(VI).
messages: extracellular matrix

9031:ATG4A
gene id: 9031:ATG4A
uniprot id: A0A1I7Q405
uniprot id: Q5ZIW7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy.
messages: Cytoplasm
messages: The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins. Required for proteolytic activation and delipidation of ATG8 proteins.

9031:RBM38
gene id: 9031:RBM38
uniprot id: Q5ZJX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM38 family.
messages: Nucleus
messages: RNA-binding protein that specifically bind the 3'-UTR of some transcripts, leading to maintain their stability. Also acts as a mRNA splicing factor. May play a role in myogenic differentiation (By similarity).
messages: cytosol

9031:ZFYVE9
gene id: 9031:ZFYVE9
uniprot id: E1C6T3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9031:TOR1A
gene id: 9031:TOR1A
uniprot id: Q5ZIP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9031:ERGIC2
gene id: 9031:ERGIC2
uniprot id: E1C3D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9031:CHMP1B
gene id: 9031:CHMP1B
uniprot id: Q5ZKX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome
messages: Late endosome membrane
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III).
messages: cytosol

9031:TRH
gene id: 9031:TRH
uniprot id: Q6ZXC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9031:TRIO
gene id: 9031:TRIO
uniprot id: A0A1D5NZW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm

9031:XPO4
gene id: 9031:XPO4
uniprot id: Q5ZMR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Mediates the nuclear export of proteins (cargos) with broad substrate specificity.
messages: Nucleus

9031:DTL
gene id: 9031:DTL
uniprot id: Q5ZJW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat cdt2 family.
messages: Chromosome
messages: Component of the DCX(DTL) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DTL/CDT2 and RBX1.
messages: Nucleus
messages: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity). May play a role in the regulation of the circadian clock (By similarity).
messages: centrosome

9031:ATRN
gene id: 9031:ATRN
uniprot id: A0A8V0ZBQ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:OCM1
gene id: 9031:OCM1
uniprot id: P43305
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the parvalbumin family.
messages: Binds two calcium ions.
messages: Restricted to the thymic stroma.
messages: This parvalbumin has an isoelectric point of 4.6.

9031:TPD52
gene id: 9031:TPD52
uniprot id: A0A8V0XJM2
uniprot id: A0A8V0XME1
uniprot id: Q5ZHP4
names: Similarity
messages: Belongs to the TPD52 family.

9031:FMR1
gene id: 9031:FMR1
uniprot id: A0A8V0YPG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9031:CAT
gene id: 9031:CAT
uniprot id: Q5ZMM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

9031:MCM3
gene id: 9031:MCM3
uniprot id: Q5ZMN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus

9031:FOXQ1
gene id: 9031:FOXQ1
uniprot id: A0A8V0YLB3
names: Subcellular Location Annotation
messages: Nucleus

9031:ID2
gene id: 9031:ID2
uniprot id: O73933
names: Subcellular Location Annotation
messages: Nucleus

9031:LOC100857744
gene id: 9031:LOC100857744
uniprot id: P42165
uniprot id: Q38IF1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears first at 3 hours post-infection, increases to give the strongest signal at about 9 hours and gradually wanes to almost nothing at 24 hours.
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:MYOG
gene id: 9031:MYOG
uniprot id: C4P6Q3
uniprot id: P17920
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).
messages: Homodimer and heterodimer. Efficient DNA binding requires dimerization with another bHLH protein (By similarity).
messages: Nucleus

9031:GRPR
gene id: 9031:GRPR
uniprot id: Q802E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:OPNVA
gene id: 9031:OPNVA
uniprot id: A7M6L0
uniprot id: A8QJE7
uniprot id: D0E2W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9031:GSTT1
gene id: 9031:GSTT1
uniprot id: P20135
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.

9031:RNP
gene id: 9031:RNP
uniprot id: A9CDT7
names: Subcellular Location Annotation
messages: Secreted

9031:OGFOD1
gene id: 9031:OGFOD1
uniprot id: F1NBM0
names: Similarity
messages: Belongs to the TPA1 family.

9031:SST1
gene id: 9031:SST1
uniprot id: A5YW27
uniprot id: P33094
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted
messages: Somatostatin inhibits the release of somatotropin.

9031:TMEM68
gene id: 9031:TMEM68
uniprot id: Q5ZJD8
names: Subcellular Location Annotation
messages: Membrane

9031:NAPG
gene id: 9031:NAPG
uniprot id: E1BWS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9031:NUP93
gene id: 9031:NUP93
uniprot id: Q5F386
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9031:DAPK3
gene id: 9031:DAPK3
uniprot id: A0A1D5PRN8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:HSD17B1
gene id: 9031:HSD17B1
uniprot id: O12968
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Favors the reduction of estrogens and androgens. Uses preferentially NADH.

9031:GREM2
gene id: 9031:GREM2
uniprot id: A0A3Q3AYA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9031:SMG1
gene id: 9031:SMG1
uniprot id: A0A1D5PE85
uniprot id: E1BW33
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9031:MYL9
gene id: 9031:MYL9
uniprot id: P02612
names: Function
names: Miscellaneous
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).
messages: This chain binds calcium.

9031:FMO3
gene id: 9031:FMO3
uniprot id: Q8QH01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9031:RECQL5
gene id: 9031:RECQL5
uniprot id: D3KR67
uniprot id: Q8AYS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9031:AMH
gene id: 9031:AMH
uniprot id: Q788U7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

9031:PARL
gene id: 9031:PARL
uniprot id: F1NUI6
names: Subcellular Location Annotation
messages: Membrane

9031:SMG7
gene id: 9031:SMG7
uniprot id: A0A1D5PMZ7
uniprot id: A0A8V0Y557
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

9031:IL12B
gene id: 9031:IL12B
uniprot id: Q6X0K9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-12B family.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Secreted

9031:ARSK
gene id: 9031:ARSK
uniprot id: Q5ZK90
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity).
messages: Lysosome
messages: Secreted
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:TALDO1
gene id: 9031:TALDO1
uniprot id: Q5ZKN8
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

9031:SIAH3
gene id: 9031:SIAH3
uniprot id: R4GKE1
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9031:CA3A
gene id: 9031:CA3A
uniprot id: A0A1D5NTS2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9031:NUP85
gene id: 9031:NUP85
uniprot id: Q5ZIU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9031:BTG2
gene id: 9031:BTG2
uniprot id: A0A3Q3AWP4
names: Similarity
messages: Belongs to the BTG family.

9031:UNC119
gene id: 9031:UNC119
uniprot id: A0A8V1AI80
names: Similarity
messages: Belongs to the PDE6D/unc-119 family.

9031:CFL2
gene id: 9031:CFL2
uniprot id: P21566
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the actin-binding proteins ADF family.
messages: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
messages: Nucleus matrix
messages: The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
messages: Widely distributed in various tissues.
messages: cytoskeleton

9031:LECT1
gene id: 9031:LECT1
uniprot id: Q9PUU8
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
messages: Belongs to the chondromodulin-1 family.
messages: Bifunctional growth regulator. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity).
messages: Endomembrane system
messages: Expressed in the cartilage and in fetal precartilaginous tissues as well as in heart and eye.
messages: Expression onset occurs between stage 10 and stage 13.
messages: extracellular matrix

9031:SOX3
gene id: 9031:SOX3
uniprot id: Q9PSV6
names: Subcellular Location Annotation
messages: Nucleus

9031:DENND5B
gene id: 9031:DENND5B
uniprot id: A0A1L1RPK6
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:LRP1
gene id: 9031:LRP1
uniprot id: P98157
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the LDLR family.
messages: Binds vitellogenin and LRPAP1 (alpha 2-macroglobulin).
messages: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated.
messages: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an alpha-2-macroglobulin receptor.
messages: Membrane
messages: Somatic.
messages: coated pit

9031:COL4A1
gene id: 9031:COL4A1
uniprot id: A0A1D5P8P3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9031:IMPA1
gene id: 9031:IMPA1
uniprot id: A0A1D5PHE2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9031:IL6R
gene id: 9031:IL6R
uniprot id: Q5DWQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.
messages: Membrane

9031:TSN
gene id: 9031:TSN
uniprot id: P79769
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots (By similarity).
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand (By similarity).
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9031:BF2
gene id: 9031:BF2
uniprot id: Q95601
names: Similarity
messages: Belongs to the MHC class I family.

9031:GCLC
gene id: 9031:GCLC
uniprot id: F1NQZ9
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9031:TRIP13
gene id: 9031:TRIP13
uniprot id: E1C6Q1
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways (By similarity).

9031:TIMM8A
gene id: 9031:TIMM8A
uniprot id: F1NIC5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9031:UXS1
gene id: 9031:UXS1
uniprot id: E1BV28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

9031:AOC3
gene id: 9031:AOC3
uniprot id: A0A8V1A8Q8
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9031:ARL8B
gene id: 9031:ARL8B
uniprot id: F1P0Z7
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9031:MFSD1
gene id: 9031:MFSD1
uniprot id: A0A8V0X1H2
uniprot id: F1P182
uniprot id: Q5ZIT9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily.
messages: Homodimer.
messages: Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP.
messages: Lysosome membrane
messages: Membrane
messages: Not N-glycosylated.
messages: The dileucine internalization motif is required for lysosomal localization.

9031:COPA
gene id: 9031:COPA
uniprot id: Q5F354
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9031:CPEB1
gene id: 9031:CPEB1
uniprot id: A0A8V0ZW49
names: Similarity
messages: Belongs to the RRM CPEB family.

9031:CREM
gene id: 9031:CREM
uniprot id: A0A1D5PT13
names: Subcellular Location Annotation
messages: Nucleus

9031:DCLK1
gene id: 9031:DCLK1
uniprot id: A0A1D5P0Z1
uniprot id: A0A3Q2U592
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9031:DNMT3A
gene id: 9031:DNMT3A
uniprot id: A0A1D5NTR2
uniprot id: Q4W5Z4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Chromosome
messages: Cytoplasm
messages: Nucleus
messages: Required for genome-wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity. Also has weak auto-methylation activity on some Cys residue in absence of DNA.
messages: The PWWP domain is essential for targeting to pericentric heterochromatin.

9031:GSTA4
gene id: 9031:GSTA4
uniprot id: Q9W6J2
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9031:PSMB5
gene id: 9031:PSMB5
uniprot id: P34065
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Directly interacts with POMP. Interacts with ABCB1 and TAP1.

9031:GATA6
gene id: 9031:GATA6
uniprot id: P43693
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: More abundant in stomach, and in small intestine. Lower levels in lung, liver, ovary and heart.
messages: Nucleus
messages: Transcriptional activator.

9031:CHAC2
gene id: 9031:CHAC2
uniprot id: F1NE73
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9031:SIN3A
gene id: 9031:SIN3A
uniprot id: E1BX21
names: Subcellular Location Annotation
messages: Nucleus

9031:TCF7L2
gene id: 9031:TCF7L2
uniprot id: A0A1D5P979
uniprot id: A0A8V0Z222
uniprot id: A0A8V0Z8F7
uniprot id: A0A8V0ZFC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9031:CCNA2
gene id: 9031:CCNA2
uniprot id: P43449
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
messages: Cytoplasm
messages: Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes.
messages: Nucleus

9031:POU6F2
gene id: 9031:POU6F2
uniprot id: A0A8V0YYR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9031:ALOX5AP
gene id: 9031:ALOX5AP
uniprot id: R4GHN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:LOC101747367
gene id: 9031:LOC101747367
uniprot id: A0A8V0ZED1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

9031:FYTTD1
gene id: 9031:FYTTD1
uniprot id: Q5ZJ20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the UIF family.
messages: Nucleus speckle
messages: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore (By similarity).
messages: Widely expressed.
messages: nucleoplasm

9031:PSMA4
gene id: 9031:PSMA4
uniprot id: F1NC02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9031:HOXA2
gene id: 9031:HOXA2
uniprot id: Q08727
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Proboscipedia subfamily.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:BIRC2
gene id: 9031:BIRC2
uniprot id: Q90660
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apoptotic suppressor.
messages: Belongs to the IAP family.
messages: Cells of the T-lymphocyte lineage. Found in both cortical and medullary cells of the thymus. Expressed at relatively high levels also in spleen, bursa, intestine and lung and at very low levels in testis, brain and skeletal muscle.
messages: Cytoplasm
messages: High levels are induced within 4-8 hours of T-cell activation in spleen and thymus.
messages: Nucleus
messages: The ring finger is important for its antiapoptotic effect.

9031:ARHGEF3
gene id: 9031:ARHGEF3
uniprot id: A0A8V1A1T2
uniprot id: Q5ZLX4
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9031:KDR
gene id: 9031:KDR
uniprot id: Q677M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9031:PEMT
gene id: 9031:PEMT
uniprot id: Q5ZJB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9031:OPNP
gene id: 9031:OPNP
uniprot id: P51475
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Pineal gland.
messages: Produces a slow and prolonged phototransduction response consistent with the non-visual function of pineal photoreception.

9031:SS18L2
gene id: 9031:SS18L2
uniprot id: E1BUW3
names: Similarity
messages: Belongs to the SS18 family.

9031:TM4SF1a
gene id: 9031:TM4SF1a
uniprot id: R4GLJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9031:HNF4G
gene id: 9031:HNF4G
uniprot id: A0A8V0XA13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:IRX4
gene id: 9031:IRX4
uniprot id: Q9YGS0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: All stages of heart development.
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus
messages: Regulates the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain-1 (Vmhc1) and suppressing the expression of the atrial myosin heavy chain-1 (Amhc1) in the ventricles. May play a critical role in establishing chamber-specific gene expression in the developing heart.
messages: Ventricles of the heart, developing feather buds, retina, hindbrain.

9031:MAFF
gene id: 9031:MAFF
uniprot id: Q90595
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. Maf subfamily.
messages: Highly expressed in the ovary, lower expression in the brain, heart and mesenterium.
messages: Monomer and homo- or heterodimer.
messages: Nucleus
messages: Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerizes among itself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response.

9031:CCNA1
gene id: 9031:CCNA1
uniprot id: F1P4N0
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9031:KIF1B
gene id: 9031:KIF1B
uniprot id: A0A3Q2UDS2
uniprot id: A0A8V0Z471
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

9031:CLUAP1
gene id: 9031:CLUAP1
uniprot id: A0A8V0Z465
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9031:JUP
gene id: 9031:JUP
uniprot id: E1C1V3
names: Similarity
messages: Belongs to the beta-catenin family.

9031:AGO4
gene id: 9031:AGO4
uniprot id: Q5ZMW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family. Ago subfamily.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9031:ACTG1
gene id: 9031:ACTG1
uniprot id: P53478
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9031:SYT1
gene id: 9031:SYT1
uniprot id: P47191
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes.
messages: Cytoplasm
messages: Homotetramer.
messages: The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
messages: The second C2 domain mediates interaction with SV2A and probably with STN2.
messages: chromaffin granule membrane
messages: secretory vesicle membrane
messages: synaptic vesicle membrane

9031:TAP1
gene id: 9031:TAP1
uniprot id: A5HUM0
uniprot id: B5BSK4
names: Subcellular Location Annotation
messages: Membrane

9031:C9ORF58
gene id: 9031:C9ORF58
uniprot id: X2J6L4
names: Subcellular Location Annotation
messages: ruffle membrane

9031:CCZ1
gene id: 9031:CCZ1
uniprot id: Q5ZLN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCZ1 family.
messages: Lysosome membrane

9031:PCDHA7
gene id: 9031:PCDHA7
uniprot id: Q6R0I4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:WLS
gene id: 9031:WLS
uniprot id: Q5ZLR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: May play an essential role in Wnt signaling pathway. May be required for Wnt-dependent patterning processes (By similarity).

9031:FLT1
gene id: 9031:FLT1
uniprot id: Q8QHL3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on tyrosine residues upon ligand binding.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Endosome
messages: Interacts with VEGFA, VEGFB and PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in the presence of bound VEGFA, VEGFB and PGF (By similarity).
messages: Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFB or PGF leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: Secreted
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates PLCG1. Promotes phosphorylation of AKT1 and CBL (By similarity).

9031:IL2RB
gene id: 9031:IL2RB
uniprot id: I3PL65
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.

9031:TLR3
gene id: 9031:TLR3
uniprot id: A0A1L4FLS3
uniprot id: Q0PQ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9031:SH2B1
gene id: 9031:SH2B1
uniprot id: A0A8V1AHB4
names: Similarity
messages: Belongs to the SH2B adapter family.

9031:CNTNAP5
gene id: 9031:CNTNAP5
uniprot id: A0A8V0ZLH9
uniprot id: Q0V8S9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neurexin family.
messages: Expressed in brain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.
messages: Membrane

9031:MYO1E
gene id: 9031:MYO1E
uniprot id: A0A8V0ZXK6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:AURKAIP1
gene id: 9031:AURKAIP1
uniprot id: Q5ZJI3
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.

9031:ITGB3
gene id: 9031:ITGB3
uniprot id: Q92071
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9031:TWF1
gene id: 9031:TWF1
uniprot id: A0A8V0XDW8
uniprot id: Q5ZLN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9031:ALAS1
gene id: 9031:ALAS1
uniprot id: P07997
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Ubiquitous.

9031:SDC3
gene id: 9031:SDC3
uniprot id: P26261
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan that may bear both heparan sulfate and chondroitin sulfate. The multiple functional domains provide potential sites for mediating the adhesive cell-matrix interactions and cytoskeletal reorganization involved in limb chondrogenesis. Interaction with other matrix ligands as well as phosphorylation and shedding of the ectodomain might be involved in cell shape changes that occur during chondrogenesis. Furthermore, shedding of the ectodomain might break the adhesive interactions that promoted condensation, thus facilitating the deposition of cartilage matrix molecules.
messages: Expressed in high amounts at the onset of limb cartilage differentiation.
messages: Membrane
messages: O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules.
messages: Proximal chondrogenic central core of embryonic limb buds where cartilage differentiation is being initiated.

9031:IRF1
gene id: 9031:IRF1
uniprot id: M4M675
uniprot id: Q90876
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by CK2 and this positively regulates its activity.
messages: Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-271. Sumoylation is enhanced by PIAS3. Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites (By similarity).
messages: Transcriptional regulator that specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes (By similarity). Acts as a tumor suppressor (By similarity).
messages: Ubiquitinated. Appears to compete with sumoylation on C-terminal sites (By similarity).

9031:SHKBP1
gene id: 9031:SHKBP1
uniprot id: E1C9F1
names: Similarity
messages: Belongs to the KCTD3 family.

9031:ONECUT1
gene id: 9031:ONECUT1
uniprot id: A0A1D5NY75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9031:LOC107052803
gene id: 9031:LOC107052803
uniprot id: A0A1D5P312
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:DDI2
gene id: 9031:DDI2
uniprot id: A0A1D5NXK6
uniprot id: A0A8V0ZI87
names: Similarity
messages: Belongs to the DDI1 family.

9031:GPR18
gene id: 9031:GPR18
uniprot id: F1NA96
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:HBZ
gene id: 9031:HBZ
uniprot id: P02007
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the globin family.
messages: Only one chromosomal locus was found, suggesting that the pi gene either does not exist or is an allele of the pi' gene.
messages: The pi' chain is the counterpart of the alpha chain in the major early embryonic hemoglobin P.

9031:UBXN2B
gene id: 9031:UBXN2B
uniprot id: Q5ZLK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. Regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
messages: Belongs to the NSFL1C family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Nucleus
messages: centrosome
messages: cytosol

9031:NXPE3
gene id: 9031:NXPE3
uniprot id: E1C8F5
names: Similarity
messages: Belongs to the NXPE family.

9031:PSMD5
gene id: 9031:PSMD5
uniprot id: Q5F3P0
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9031:PSPC1
gene id: 9031:PSPC1
uniprot id: Q5ZK88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSPC family.
messages: Cytoplasm
messages: Nucleus matrix
messages: Nucleus speckle
messages: Together with NONO, required for the formation of nuclear paraspeckles. Acts as a coactivator during transcriptional activation. Binds to RNA. May act as a regulator the circadian clock (By similarity).
messages: nucleolus

9031:GORASP2
gene id: 9031:GORASP2
uniprot id: Q5F353
names: Similarity
messages: Belongs to the GORASP family.

9031:VKORC1L1
gene id: 9031:VKORC1L1
uniprot id: F1P573
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:UNC5D
gene id: 9031:UNC5D
uniprot id: A0A1D5P4F5
uniprot id: A0A1D5PNP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9031:ITGB2
gene id: 9031:ITGB2
uniprot id: A0A8V0YJ29
uniprot id: Q92070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9031:TPT1
gene id: 9031:TPT1
uniprot id: P43347
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Involved in calcium binding and microtubule stabilization.

9031:LARGE1
gene id: 9031:LARGE1
uniprot id: Q66PG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (By similarity). Plays a key role in skeletal muscle function and regeneration (By similarity).
messages: Binds 2 Mn(2+) ions per subunit. The xylosyltransferase part binds one Mn(2+) and the beta-1,3-glucuronyltransferase part binds one Mn(2+).
messages: Golgi apparatus membrane
messages: In the C-terminal section; belongs to the glycosyltransferase 49 family.
messages: In the N-terminal section; belongs to the glycosyltransferase 8 family.

9031:RAPSN
gene id: 9031:RAPSN
uniprot id: O42393
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.
messages: Belongs to the RAPsyn family.
messages: Cell membrane
messages: Expressed in muscle fibers and in neurons.
messages: Postsynaptic cell membrane
messages: Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity).
messages: cytoskeleton

9031:NAF1
gene id: 9031:NAF1
uniprot id: A0A8V0XQ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

9031:NDUFA13
gene id: 9031:NDUFA13
uniprot id: A0A1D5P179
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

9031:EDEM1
gene id: 9031:EDEM1
uniprot id: Q5ZK76
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9031:OLFR4
gene id: 9031:OLFR4
uniprot id: Q90808
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:HADH
gene id: 9031:HADH
uniprot id: E1BZH9
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9031:LMOD2
gene id: 9031:LMOD2
uniprot id: E1BTG2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomodulin family.
messages: Can bind at least three actin monomers and thereby provides a nucleus for actin filament formation. Interacts (via N-terminus) with tropomyosin alpha (TPM1) (via N-terminus). May also interact with TPM2 (via N-terminus).
messages: First detected in myocardium at HH stage 14. Detected in myocardium and somites at HH stage 17 and 19.
messages: M line
messages: Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length (PubMed:20736303). Required for normal sarcomere organization in the heart, and for normal heart function (By similarity).
messages: cytoskeleton
messages: myofibril
messages: sarcomere

9031:PTS
gene id: 9031:PTS
uniprot id: F1NL99
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9031:ARF6
gene id: 9031:ARF6
uniprot id: P26990
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity).
messages: In 3 days embryos.
messages: Midbody ring
messages: Recycling endosome membrane
messages: cytosol
messages: filopodium membrane
messages: ruffle

9031:PARP11
gene id: 9031:PARP11
uniprot id: A0A1D5P5E7
uniprot id: A0A8V1A6E7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:ATP5E
gene id: 9031:ATP5E
uniprot id: A0A3Q2TXM3
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9031:PLLP
gene id: 9031:PLLP
uniprot id: Q5ZIE5
names: Subcellular Location Annotation
messages: Membrane

9031:TSHB
gene id: 9031:TSHB
uniprot id: A5YW28
uniprot id: O57340
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Indispensable for the control of thyroid structure and metabolism.
messages: Secreted

9031:HIST1H103
gene id: 9031:HIST1H103
uniprot id: P08285
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

9031:CXCL12
gene id: 9031:CXCL12
uniprot id: A0A8V0ZMM6
uniprot id: Q6T7C0
names: Similarity
messages: Belongs to the intercrine alpha (chemokine CxC) family.

9031:VAX1
gene id: 9031:VAX1
uniprot id: Q9PVN2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: First detected within the ventral eye at Hamburger-Hamilton (HH) stage 14 as the optic vesicle invaginates. Expression restricted to the ventral retina at HH stage 22 and at 4 dpc as well as later in development.
messages: Nucleus
messages: Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina.

9031:DUOXA1L
gene id: 9031:DUOXA1L
uniprot id: A0A1D5PDQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9031:DYL2
gene id: 9031:DYL2
uniprot id: E1C5T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9031:FLNB
gene id: 9031:FLNB
uniprot id: A0A1D5NYG3
names: Similarity
messages: Belongs to the filamin family.

9031:PFKM
gene id: 9031:PFKM
uniprot id: Q90YA3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PDHX
gene id: 9031:PDHX
uniprot id: Q5F3G9
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

9031:FGF2
gene id: 9031:FGF2
uniprot id: P48800
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity).
messages: Belongs to the heparin-binding growth factors family.
messages: Nucleus
messages: Secreted

9031:KIF2C
gene id: 9031:KIF2C
uniprot id: A0A8V1A697
uniprot id: A0A8V1A8V3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:USP5
gene id: 9031:USP5
uniprot id: A0A8V0ZUX9
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:MMP27
gene id: 9031:MMP27
uniprot id: O93342
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9031:PPP2CB
gene id: 9031:PPP2CB
uniprot id: P48463
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. May indirectly interact with SGOL1, most probably through regulatory B56 subunits (By similarity).
messages: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
messages: Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation (By similarity).
messages: Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity).
messages: centromere
messages: spindle pole

9031:NOP56
gene id: 9031:NOP56
uniprot id: Q5ZMD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9031:TNFSF8
gene id: 9031:TNFSF8
uniprot id: Q800J1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9031:HSPA9
gene id: 9031:HSPA9
uniprot id: Q5ZM98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging.
messages: Interacts strongly with the intermediate form of FXN and weakly with its mature form. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Mitochondrion

9031:HOXA10
gene id: 9031:HOXA10
uniprot id: E1C8Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9031:OPTC
gene id: 9031:OPTC
uniprot id: Q6YEX8
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9031:PA2G4
gene id: 9031:PA2G4
uniprot id: A0A1D5P7C6
names: Similarity
messages: Belongs to the peptidase M24 family.

9031:MYO6
gene id: 9031:MYO6
uniprot id: Q9I8D1
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Divided into three regions: a N-terminal motor (head) domain, followed by a neck domain consisting of a calmodulin-binding linker domain and a single IQ motif, and a C-terminal tail region with a three-helix bundle region, a SAH domain and a unique globular domain required for interaction with other proteins such as cargo-binding.
messages: Golgi apparatus
messages: Homodimer; dimerization seems to implicate the unfolding of the three-helix bundle region creating an additional calmodulin binding site, and cargo binding (By similarity). Able to function as a monomer under specific conditions in vitro (By similarity). Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells (By similarity). Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal (By similarity). This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium (By similarity). Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (By similarity). Interacts with DAB2 (By similarity). In vitro, the C-terminal globular tail binds a C-terminal region of DAB2 (By similarity). Interacts with CFTR (By similarity). Interacts with OPTN (PubMed:15837803). Interacts with CABP5 (By similarity). Interacts (via residues 1139-1257) with TOM1 (via residues 397-488) (By similarity). Interacts with TAX1BP1 and CALCOCO2/NDP52 (By similarity). Interacts with TOM1L2 (By similarity).
messages: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (By similarity). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (By similarity). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (By similarity). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (By similarity). May act as a regulator of F-actin dynamics (By similarity). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Modulates RNA polymerase II-dependent transcription (By similarity).
messages: Nucleus
messages: Originally predicted to contain a coiled coil domain but generally accepted to contain a stable SAH domain instead.
messages: Phosphorylation in the motor domain, induced by EGF, results in translocation of MYO6 from the cell surface to membrane ruffles. Phosphorylated in vitro by p21-activated kinase (PAK).
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-6 (MYH6).
messages: The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds (By similarity). Its contribution to the mechanism confering the myosin movement on actin filaments is debated (By similarity).
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: clathrin-coated vesicle membrane
messages: cytosol
messages: filopodium
messages: microvillus
messages: perinuclear region
messages: ruffle membrane
messages: trans-Golgi network membrane

9031:REL
gene id: 9031:REL
uniprot id: P16236
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex. Component of the NF-KAPPA-B p65-c-Rel complex.
messages: Nucleus
messages: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator (By similarity).

9031:E2F5
gene id: 9031:E2F5
uniprot id: Q5ZI31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9031:GADD45G
gene id: 9031:GADD45G
uniprot id: Q2HZD5
names: Similarity
messages: Belongs to the GADD45 family.

9031:TPRG1L
gene id: 9031:TPRG1L
uniprot id: F1P107
names: Similarity
messages: Belongs to the TPRG1 family.

9031:LOC100857297
gene id: 9031:LOC100857297
uniprot id: A0A1D5PSK7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:RPS4Y1
gene id: 9031:RPS4Y1
uniprot id: P47836
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

9031:LAMP3
gene id: 9031:LAMP3
uniprot id: B0BL88
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9031:GRIA3
gene id: 9031:GRIA3
uniprot id: P79776
uniprot id: Q90731
uniprot id: Q90857
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:RDM1
gene id: 9031:RDM1
uniprot id: Q8JFQ4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Confers resistance to the antitumor agent cisplatin. Binds preferentially to sites of DNA modified by cisplatin in vitro. Binds to double-stranded DNA in a cooperative manner resulting in the formation of filament-like structures. Binds to single-stranded DNA with no cooperativity. Binds to RNA.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: nucleolus

9031:TMBIM4
gene id: 9031:TMBIM4
uniprot id: E1C1Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9031:NMUR1
gene id: 9031:NMUR1
uniprot id: E1BWP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

9031:UCN3
gene id: 9031:UCN3
uniprot id: E1BUW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9031:ANXA1
gene id: 9031:ANXA1
uniprot id: Q6QAZ9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium

9031:UBE2A
gene id: 9031:UBE2A
uniprot id: Q9W6F3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:NETO2
gene id: 9031:NETO2
uniprot id: A0A1D5P8L8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:HOXA1
gene id: 9031:HOXA1
uniprot id: R4GHI8
names: Subcellular Location Annotation
messages: Nucleus

9031:PROC
gene id: 9031:PROC
uniprot id: Q804X5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:FAM19A4
gene id: 9031:FAM19A4
uniprot id: A0A8V0ZB42
names: Similarity
messages: Belongs to the TAFA family.

9031:DEGS1
gene id: 9031:DEGS1
uniprot id: Q5F3C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Expressed in retina and retinal pigment epithelium by Mueller cells (at protein level).
messages: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity). Catalyzes the equilibrium isomerization of retinols (PubMed:23143414).
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.

9031:FGF8
gene id: 9031:FGF8
uniprot id: Q4R0X9
uniprot id: Q90722
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs.
messages: Secreted

9031:CFDP1
gene id: 9031:CFDP1
uniprot id: Q75QI0
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

9031:ADRA2C
gene id: 9031:ADRA2C
uniprot id: F1NDD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:AKT1
gene id: 9031:AKT1
uniprot id: O57513
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9031:SH3BP4
gene id: 9031:SH3BP4
uniprot id: F1P4F1
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9031:PROK2
gene id: 9031:PROK2
uniprot id: F1NP50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9031:SS18
gene id: 9031:SS18
uniprot id: A0A1D5PX83
uniprot id: Q5ZMA8
names: Similarity
messages: Belongs to the SS18 family.

9031:CRYGS
gene id: 9031:CRYGS
uniprot id: D0UYB8
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9031:B4GALT2
gene id: 9031:B4GALT2
uniprot id: Q92073
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:RSPO3
gene id: 9031:RSPO3
uniprot id: M4M6X6
names: Similarity
messages: Belongs to the R-spondin family.

9031:LPP
gene id: 9031:LPP
uniprot id: Q5F464
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zyxin/ajuba family.
messages: Cell junction
messages: Cytoplasm
messages: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. May be involved in signal transduction from cell adhesion sites to the nucleus (By similarity).
messages: Nucleus

9031:AKT3
gene id: 9031:AKT3
uniprot id: A0A1D5NTY9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9031:MAPKAP1
gene id: 9031:MAPKAP1
uniprot id: A0A3Q2U9J6
uniprot id: A0A3Q2UHQ6
uniprot id: Q9W6S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SIN1 family.
messages: Essential component of the TORC2 complex, which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).
messages: Part of the target of rapamycin 2 complex (TORC2).

9031:SCNM1
gene id: 9031:SCNM1
uniprot id: A0A8V1AJG7
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: nucleoplasm

9031:POSTN
gene id: 9031:POSTN
uniprot id: A0A3Q2U321
uniprot id: F1P4N9
uniprot id: Q6DMS3
names: Subcellular Location Annotation
messages: extracellular matrix

9031:NT5C3B
gene id: 9031:NT5C3B
uniprot id: Q5ZKF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm
messages: Monomer.
messages: Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity).

9031:VGLL2
gene id: 9031:VGLL2
uniprot id: A0A8V0Y957
uniprot id: A0A8V0YFF2
uniprot id: C0KDW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

9031:RAB14
gene id: 9031:RAB14
uniprot id: Q5ZKU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity).
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9031:NRDC
gene id: 9031:NRDC
uniprot id: Q5ZMI8
names: Similarity
messages: Belongs to the peptidase M16 family.

9031:ADA
gene id: 9031:ADA
uniprot id: Q5ZKP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity).
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle lumen
messages: Lysosome

9031:NMD3
gene id: 9031:NMD3
uniprot id: E1BTL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9031:SOX10
gene id: 9031:SOX10
uniprot id: Q9W757
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.
messages: Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination.

9031:SLC24A2
gene id: 9031:SLC24A2
uniprot id: A0A1L1RQA3
uniprot id: Q9IAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:10662833). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synaptic plasticity (By similarity).
messages: Cell membrane
messages: Membrane
messages: Retinal cones (PubMed:10662833). Found in the cone inner segment layer and in a subpopulation of ganglion cells (PubMed:10662833).

9031:CD36
gene id: 9031:CD36
uniprot id: Q5ZLI8
names: Similarity
messages: Belongs to the CD36 family.

9031:GLS2
gene id: 9031:GLS2
uniprot id: A0A8V0YM08
names: Similarity
messages: Belongs to the glutaminase family.

9031:GRK7
gene id: 9031:GRK7
uniprot id: E1C4P5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9031:GTPBP4
gene id: 9031:GTPBP4
uniprot id: Q5ZM18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9031:GPD2
gene id: 9031:GPD2
uniprot id: F1NCA2
names: Function
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.

9031:TEAD3
gene id: 9031:TEAD3
uniprot id: A0A8V1A931
uniprot id: A0A8V1AE10
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

9031:STK40
gene id: 9031:STK40
uniprot id: Q7T0B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9031:NKX6-2
gene id: 9031:NKX6-2
uniprot id: A0A3Q2UGY9
names: Subcellular Location Annotation
messages: Nucleus

9031:TMEM106B
gene id: 9031:TMEM106B
uniprot id: A0A1D5PUI5
uniprot id: Q5F3Z0
names: Similarity
messages: Belongs to the TMEM106 family.

9031:AOX1
gene id: 9031:AOX1
uniprot id: Q2QB50
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9031:TNFRSF1A
gene id: 9031:TNFRSF1A
uniprot id: Q5ZJG1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:C1R
gene id: 9031:C1R
uniprot id: F1NAB7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:HGF
gene id: 9031:HGF
uniprot id: Q788Q2
uniprot id: Q90978
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9031:CDC73
gene id: 9031:CDC73
uniprot id: Q5ZLM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC73 family.
messages: Component of the PAF1 complex, which at least consists of CDC73, PAF1, LEO1, CTR9 and RTF1.
messages: Nucleus
messages: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).

9031:MGME1
gene id: 9031:MGME1
uniprot id: A0A1L1RXX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGME1 family.
messages: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair.
messages: Mitochondrion

9031:SLC16A3
gene id: 9031:SLC16A3
uniprot id: P57788
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Interacts with BSG; interaction mediates SLC16A3 targeting to the plasma membrane.
messages: Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (By similarity). Plays a predominant role in the L-lactate efflux from highly glycolytic cells (By similarity).
messages: Two basolateral sorting signals (BSS) in its C-terminal cytoplasmic tail are required to direct SLC16A3 to the basolateral membrane.
messages: Was initially thought to be considered to be a low affinity lactate transporter with negligible affinity for pyruvate (By similarity). However, it was later shown that SLC16A3 is a high affinity lactate transporter with physiologically relevant affinity for pyruvate (By similarity).

9031:MSTN
gene id: 9031:MSTN
uniprot id: O42220
uniprot id: Q06BS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

9031:FNTA
gene id: 9031:FNTA
uniprot id: A0A8V0YTE3
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9031:AP1S3
gene id: 9031:AP1S3
uniprot id: E1BWN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9031:GABRA5
gene id: 9031:GABRA5
uniprot id: A0A8V0XHI4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:PIWIL1
gene id: 9031:PIWIL1
uniprot id: A6N7Y9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family. Piwi subfamily.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs (By similarity).
messages: Methylated on arginine residues; required for the interaction with Tudor domain-containing protein and subsequent localization to the meiotic nuage, also named P granule.
messages: The PAZ domain specifically recognizes binds the 2'-O-methylated 3'-end of piRNAs. The MID region is required for recognition of uridine in the first position of piRNAs (g1U preference, also named 1U-bias).

9031:PRMT3
gene id: 9031:PRMT3
uniprot id: A0A8V0ZDB2
uniprot id: A0A8V0ZJS9
uniprot id: F1NYG2
names: Subcellular Location Annotation
messages: Cytoplasm

9031:DACT1
gene id: 9031:DACT1
uniprot id: Q1G7H4
names: Similarity
messages: Belongs to the dapper family.

9031:MPDZ
gene id: 9031:MPDZ
uniprot id: G1JT17
names: Subcellular Location Annotation
messages: tight junction

9031:NFASC
gene id: 9031:NFASC
uniprot id: A0A1D5P601
uniprot id: A0A1D5PN99
uniprot id: A0A8V1A8K6
uniprot id: A0A8V1A8L6
uniprot id: O42414
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
messages: Cell membrane
messages: May be proteolytically cleaved at Arg-636.
messages: N-glycosylated and O-glycosylated.
messages: There is one major 'early' isoform and multiple 'late' isoforms. Around 50 isoforms are found at different developmental stages.

9031:PLCB4
gene id: 9031:PLCB4
uniprot id: A0A3Q2U0G2
uniprot id: A0A3Q3AX15
uniprot id: R4GFB3
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9031:HBBA
gene id: 9031:HBBA
uniprot id: P02112
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of 2 alpha (or alpha-D) and 2 beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D.
messages: Red blood cells.

9031:NF2L
gene id: 9031:NF2L
uniprot id: A0A3Q3AT45
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9031:FOXN2
gene id: 9031:FOXN2
uniprot id: A0A8V0Z2Y1
uniprot id: F1NV54
names: Subcellular Location Annotation
messages: Nucleus

9031:HUS1
gene id: 9031:HUS1
uniprot id: A0A1D5PTJ5
names: Similarity
messages: Belongs to the HUS1 family.

9031:NPVF
gene id: 9031:NPVF
uniprot id: Q75XU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9031:CRYAA
gene id: 9031:CRYAA
uniprot id: A3FMM9
uniprot id: P02504
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. May act as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Cytoplasm
messages: Heteropolymer composed of three CRYAA and one CRYAB subunits (By similarity). Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity).
messages: Nucleus

9031:POPDC2
gene id: 9031:POPDC2
uniprot id: Q6TRX0
names: Similarity
messages: Belongs to the popeye family.

9031:TRAF5
gene id: 9031:TRAF5
uniprot id: Q805B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9031:MRGBP
gene id: 9031:MRGBP
uniprot id: F1NRH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

9031:G6PC2
gene id: 9031:G6PC2
uniprot id: F1NTA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9031:NINJ1
gene id: 9031:NINJ1
uniprot id: R4GJU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9031:ATP5B
gene id: 9031:ATP5B
uniprot id: A0A8V1A624
uniprot id: Q5ZLC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion inner membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9031:CLTA
gene id: 9031:CLTA
uniprot id: A0A3Q2U5N2
uniprot id: Q5ZHR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9031:ISL1
gene id: 9031:ISL1
uniprot id: P50211
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator (PubMed:7528105). Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (PubMed:7528105). Acts in conjunction with LHX1, LHX3 and ISL2 (PubMed:7528105). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development (By similarity).
messages: Expressed in motor neurons between stages 34 and 35 (at protein level). Expressed prior to the formation of distinct motor axon pathways and before the segregation of motor neurons into columns. Expressed throughout the median motor column and the medial subdivision of the lateral motor column (LMCm).
messages: Nucleus

9031:CAPN3
gene id: 9031:CAPN3
uniprot id: A0A1D5PLJ8
uniprot id: A0A1L1RQ67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9031:ANAPC2
gene id: 9031:ANAPC2
uniprot id: F1NLT0
names: Similarity
messages: Belongs to the cullin family.

9031:AGTR1
gene id: 9031:AGTR1
uniprot id: P79785
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: C-terminal Ser or Thr residues may be phosphorylated.
messages: Cell membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

9031:BRS3
gene id: 9031:BRS3
uniprot id: Q802E6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9031:UBE2D3
gene id: 9031:UBE2D3
uniprot id: A0A8V0Z577
uniprot id: Q5ZL59
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:HEXB
gene id: 9031:HEXB
uniprot id: F1NTQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9031:ABHD12
gene id: 9031:ABHD12
uniprot id: Q5ZIN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Endoplasmic reticulum membrane
messages: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity).

9031:SLC25A25
gene id: 9031:SLC25A25
uniprot id: A0A3Q3AJ87
uniprot id: A0A8V1ABW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9031:ING4
gene id: 9031:ING4
uniprot id: Q5ZKY4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication.
messages: Homodimer. Component of the HBO1 complex.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9031:APOOL
gene id: 9031:APOOL
uniprot id: Q5ZK55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Mitochondrion inner membrane

9031:PPFIBP1
gene id: 9031:PPFIBP1
uniprot id: Q5F3X7
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9031:DLX1
gene id: 9031:DLX1
uniprot id: Q6DV98
names: Subcellular Location Annotation
messages: Nucleus

9031:DTX4
gene id: 9031:DTX4
uniprot id: F1NLX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9031:CTCF
gene id: 9031:CTCF
uniprot id: Q08705
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as both a transcriptional activator and repressor of the MYC gene.
messages: Belongs to the CTCF zinc-finger protein family.
messages: Nucleus

9031:AXIN1
gene id: 9031:AXIN1
uniprot id: A0A1D5P395
uniprot id: O42400
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination at 'Lys-48' and subsequent activation of the Wnt signaling pathway.
messages: Cell membrane
messages: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.
messages: Cytoplasm
messages: Expressed at stage 12 to 15.
messages: Homodimer.
messages: Membrane
messages: Nucleus
messages: Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway.

9031:SGF29
gene id: 9031:SGF29
uniprot id: Q5ZL38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF29 family.
messages: Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (By similarity). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Also binds non-histone proteins that are methylated on Lys residues (By similarity).
messages: Interacts with dimethylated and trimethylated 'Lys-4' of histone H3 (H3K4me2 and H3K4me3), with a preference for the trimethylated form (H3K4me3). Component of some SAGA-type complexes. Component of the ADA2A-containing complex (ATAC).
messages: Nucleus
messages: The SGF29 C-terminal (also named tudor-like) domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me).

9031:TBC1D23
gene id: 9031:TBC1D23
uniprot id: Q5F415
names: Function
names: Subcellular Location Annotation
messages: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development (By similarity). May act as a general inhibitor of innate immunity signaling (By similarity).
messages: trans-Golgi network

9031:NPC2
gene id: 9031:NPC2
uniprot id: Q5ZJS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9031:NIPAL3
gene id: 9031:NIPAL3
uniprot id: A0A8V0YM47
uniprot id: E1BR96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9031:COCH
gene id: 9031:COCH
uniprot id: O42163
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in inner ear structures; the spindle-shaped cells of the basilar papilla. Weaker expression found in the inferior and superior fibrocartilaginous plates and skeletal muscle.
messages: Monomer.
messages: Plays a role in the control of cell shape and motility in the trabecular meshwork.
messages: Secreted
messages: Specifically expressed at the late developmental stages in the cochlea.

9031:RGS5
gene id: 9031:RGS5
uniprot id: R4GKX0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9031:ST6GALNAC6
gene id: 9031:ST6GALNAC6
uniprot id: A0A3Q2UCV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:LMNB1
gene id: 9031:LMNB1
uniprot id: P14731
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Homodimer. Interacts with lamin-associated polypeptides IA, IB and 2.
messages: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
messages: Nucleus lamina
messages: Phosphorylated. Phosphorylation is increased before envelope disintegration and probably plays a role in regulating lamin associations (By similarity).
messages: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.

9031:TMEM2
gene id: 9031:TMEM2
uniprot id: F1NJD8
names: Similarity
messages: Belongs to the CEMIP family.

9031:ARHGAP19
gene id: 9031:ARHGAP19
uniprot id: Q5F3G0
names: Function
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

9031:BUD31
gene id: 9031:BUD31
uniprot id: E1BV47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9031:CISD2
gene id: 9031:CISD2
uniprot id: R4GLS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CISD protein family. CISD2 subfamily.
messages: Binds 1 [2Fe-2S] cluster.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Mitochondrion outer membrane
messages: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy.

9031:VCP
gene id: 9031:VCP
uniprot id: Q5ZMU9
names: Similarity
messages: Belongs to the AAA ATPase family.

9031:LOC100857191
gene id: 9031:LOC100857191
uniprot id: A0A3Q2U125
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:PIK3CB
gene id: 9031:PIK3CB
uniprot id: Q5F4A2
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:TPI1
gene id: 9031:TPI1
uniprot id: P00940
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9031:CACFD1
gene id: 9031:CACFD1
uniprot id: A0A1D5PHF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

9031:ABHD3
gene id: 9031:ABHD3
uniprot id: F1NTP8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9031:ATP6V1A
gene id: 9031:ATP6V1A
uniprot id: F1NBW2
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

9031:CAV3
gene id: 9031:CAV3
uniprot id: F1NXR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9031:KCNF1
gene id: 9031:KCNF1
uniprot id: F1NK95
names: Subcellular Location Annotation
messages: Membrane

9031:LOC107056270
gene id: 9031:LOC107056270
uniprot id: A0A8V0XUP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9031:HTATSF1
gene id: 9031:HTATSF1
uniprot id: F1P1G7
names: Similarity
messages: Belongs to the HTATSF1 family.

9031:NPY
gene id: 9031:NPY
uniprot id: P28673
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
messages: Secreted
messages: neuronal dense core vesicle

9031:PARD6B
gene id: 9031:PARD6B
uniprot id: Q0PVE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9031:COG4
gene id: 9031:COG4
uniprot id: Q5ZMU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

9031:MXRA8
gene id: 9031:MXRA8
uniprot id: A0A8V0YXS4
uniprot id: Q90WI4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer in cis. Does not appear to form trans-homodimers.
messages: Membrane
messages: Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro.

9031:ST8SIA3L
gene id: 9031:ST8SIA3L
uniprot id: A0A8V0YB47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:TEK
gene id: 9031:TEK
uniprot id: A0A3Q2UKD3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:RAD17
gene id: 9031:RAD17
uniprot id: Q76F78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

9031:BVES
gene id: 9031:BVES
uniprot id: Q9DG23
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the popeye family.
messages: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Involved in epithelial movement during corneal sheet formation and regeneration. May play a role in VAMP3-mediated vesicular transport and recycling of receptor molecules. May play a role in the regulation of cell shape and movement by modulating the Rho-GTPase activity. May be involved in skeletal muscle and heart development as well as in the maintenance of heart function (By similarity). May also be involved in striated muscle regeneration and in the regulation of cell spreading.
messages: Expressed during heart development in the proepicardial organ, migrating proepicardial strands, delaminated mesenchymal cells and vascular smooth muscle. Expressed in epithelial precursors of the cornea, lens and retina of the developing eye (at protein level). Expressed in the left ventricular segment of the tubular heart at stage 11. Expressed in the myotome, notochord and ventral half of the neuronal tube.
messages: Expressed in the heart and skeletal muscle (at protein level). Isoform 1 and isoform 4: expressed in heart, muscle, brain, stomach, kidney, lung and spleen.
messages: Homodimer. Homodimerization requires the C-terminus cytoplasmic region.
messages: Incomplete sequence.
messages: Lateral cell membrane
messages: Membrane
messages: caveola
messages: sarcolemma
messages: tight junction

9031:LOC418813
gene id: 9031:LOC418813
uniprot id: A0A3Q2UIQ3
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:IMMP1L
gene id: 9031:IMMP1L
uniprot id: F1P533
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9031:NIPSNAP3A
gene id: 9031:NIPSNAP3A
uniprot id: R4GJL1
names: Similarity
messages: Belongs to the NipSnap family.

9031:LOC396365
gene id: 9031:LOC396365
uniprot id: P09859
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Potent stimulus of gastric acid, but not of pancreatic secretion.
messages: Secreted

9031:PATL2
gene id: 9031:PATL2
uniprot id: A0A8V0ZVN2
uniprot id: A0A8V1A003
names: Similarity
messages: Belongs to the PAT1 family.

9031:SERPINI1
gene id: 9031:SERPINI1
uniprot id: Q90935
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Detected in embryonic ocular vitreous fluid (at protein level) (PubMed:9442076). In the embryo present in retina, brain, cerebellum and spinal cord (PubMed:8670795). In adult, predominantly expressed in the brain (PubMed:8670795).
messages: Perikaryon
messages: Secreted
messages: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
messages: secretory vesicle lumen

9031:VEZT
gene id: 9031:VEZT
uniprot id: A0A8V0YAZ0
uniprot id: F1P4W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9031:CALB2
gene id: 9031:CALB2
uniprot id: P07090
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9031:KALRN
gene id: 9031:KALRN
uniprot id: A0A8V0Z5A6
names: Subcellular Location Annotation
messages: Cytoplasm

9031:CTNNAL1
gene id: 9031:CTNNAL1
uniprot id: F1NMC0
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9031:AGAP3
gene id: 9031:AGAP3
uniprot id: A0A1D5PDD2
uniprot id: A0A3Q2UN32
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9031:STK38L
gene id: 9031:STK38L
uniprot id: Q5ZLR3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:SEC16B
gene id: 9031:SEC16B
uniprot id: Q6AW68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

9031:CHRNA5
gene id: 9031:CHRNA5
uniprot id: P26152
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
messages: Cell membrane
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.
messages: Postsynaptic cell membrane

9031:HOXA5
gene id: 9031:HOXA5
uniprot id: Q6B3N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity).

9031:GOSR1
gene id: 9031:GOSR1
uniprot id: Q5ZK51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9031:HMGB2
gene id: 9031:HMGB2
uniprot id: P26584
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome
messages: Cytoplasm
messages: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner (By similarity). Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA (PubMed:14672558). Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity).
messages: Nucleus
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).
messages: Secreted

9031:CYP26A1
gene id: 9031:CYP26A1
uniprot id: A0A8V0Z7G1
uniprot id: Q9PUB4
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:10588879). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (By similarity) (PubMed:10588879). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (By similarity).
messages: Belongs to the cytochrome P450 family.
messages: By retinoic acid.
messages: Endoplasmic reticulum membrane
messages: Expressed at stage 4 in the ectoderm, stage 5-7 in the nascent notochord and at stage 7 its expression decreases in the anterior part of the embryo. From stage 7-10 its expression is restricted to the dorsal folds of the neural tube and to rhombomere 2. At stage 10, it is expressed in the lateral plate endoderm and in the tail bud and by stage 11/12 it disappears in the neural tube, followed by a confined expression at stage 12 to dorsal neural tube and at stage 15 an increasing expression in the ectoderm.
messages: Microsome membrane

9031:CNGA1
gene id: 9031:CNGA1
uniprot id: Q90980
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
messages: Membrane
messages: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.

9031:RNPS1
gene id: 9031:RNPS1
uniprot id: E1BV45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus speckle

9031:SLC34A2
gene id: 9031:SLC34A2
uniprot id: Q6TQF9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9031:AGA
gene id: 9031:AGA
uniprot id: Q5ZJG0
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9031:PIAS4
gene id: 9031:PIAS4
uniprot id: A0A1D5P2D1
names: Similarity
messages: Belongs to the PIAS family.

9031:BLMH
gene id: 9031:BLMH
uniprot id: P87362
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm
messages: Homooctamer.
messages: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.

9031:DERL2
gene id: 9031:DERL2
uniprot id: A0A1D5PW06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9031:KPNB1
gene id: 9031:KPNB1
uniprot id: A0A1D5P1W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

9031:ARNTL
gene id: 9031:ARNTL
uniprot id: Q9I8T7
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated on Lys-545 by CLOCK during the repression phase of the circadian cycle. Acetylation facilitates recruitment of CRY1 protein and initiates the repression phase of the circadian cycle. Acetylated at Lys-545 by KAT5 during the activation phase of the cycle, leading to recruitment of the positive transcription elongation factor b (P-TEFb) and BRD4, followed by productive elongation of circadian transcripts. Deacetylated by SIRT1, which may result in decreased protein stability.
messages: Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins (By similarity). Forms a heterodimer with CLOCK (PubMed:10931848). The CLOCK-BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1 (By similarity). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (By similarity). Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation (By similarity). Interacts with NPAS2 (PubMed:10931848).
messages: Cytoplasm
messages: Exhibits circadian rhythm expression in the pineal gland. Maximum levels between ZT13 and ZT16 during light/dark cycle. Similar expression in constant darkness. Expression in the retinal photoreceptor cells oscillates in a circadian manner.
messages: Expressed in pineal gland and retina.
messages: Nucleus
messages: O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-BMAL1 heterodimer thereby increasing CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2/3 and CRY1/2.
messages: PML body
messages: Phosphorylated upon dimerization with CLOCK. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the CLOCK-BMAL1 heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver with a peak between CT10 to CT14. Phosphorylation at Ser-97 by CK2 is essential for its nuclear localization, its interaction with CLOCK and controls CLOCK nuclear entry. Dephosphorylation at Ser-85 is important for dimerization with CLOCK and transcriptional activity.
messages: Sumoylated on Lys-266 upon dimerization with CLOCK. Predominantly conjugated to poly-SUMO2/3 rather than SUMO1 and the level of these conjugates undergo rhythmic variation, peaking at CT9-CT12. Sumoylation localizes it exclusively to the PML body and promotes its ubiquitination in the PML body, ubiquitin-dependent proteasomal degradation and the transcriptional activity of the CLOCK-BMAL1 heterodimer.
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …
messages: Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP9X.
messages: Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.

9031:ACTR1A
gene id: 9031:ACTR1A
uniprot id: Q5ZM58
names: Similarity
messages: Belongs to the actin family.

9031:LETM1
gene id: 9031:LETM1
uniprot id: Q5ZK33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LETM1 family.
messages: Homohexamer.
messages: Mitochondrion inner membrane
messages: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Functions also as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity).

9031:LZTFL1
gene id: 9031:LZTFL1
uniprot id: A0A3Q3B012
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9031:POMK
gene id: 9031:POMK
uniprot id: Q5F349
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although related to the Ser/Thr protein kinase family, has no protein kinase activity and acts as a mannose kinase instead.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
messages: Endoplasmic reticulum membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity).

9031:SEMA7A
gene id: 9031:SEMA7A
uniprot id: A0A8V0ZB91
uniprot id: F1NIZ9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SLCO3A1
gene id: 9031:SLCO3A1
uniprot id: F1NSG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9031:ESRRG
gene id: 9031:ESRRG
uniprot id: Q5UKY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9031:DHODH
gene id: 9031:DHODH
uniprot id: Q5ZHY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9031:GJD2
gene id: 9031:GJD2
uniprot id: Q8UVE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:RPS6
gene id: 9031:RPS6
uniprot id: P47838
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Cytoplasm
messages: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest.
messages: nucleolus

9031:PIM3
gene id: 9031:PIM3
uniprot id: E1BY69
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9031:ZDHHC18
gene id: 9031:ZDHHC18
uniprot id: Q5ZHZ3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:LMF2
gene id: 9031:LMF2
uniprot id: Q5ZKZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).

9031:MST1
gene id: 9031:MST1
uniprot id: Q90865
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TACC3
gene id: 9031:TACC3
uniprot id: Q5ZLP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9031:CXCR7
gene id: 9031:CXCR7
uniprot id: A1KXM6
uniprot id: R4GKC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:SMS
gene id: 9031:SMS
uniprot id: Q5F3Z6
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9031:GRM5
gene id: 9031:GRM5
uniprot id: F1NWG3
uniprot id: Q98UC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9031:PAX5
gene id: 9031:PAX5
uniprot id: F1NKV2
uniprot id: Q9W601
names: Subcellular Location Annotation
messages: Nucleus

9031:USP15
gene id: 9031:USP15
uniprot id: A0A1D5P1U9
uniprot id: A0A1D5P9H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Nucleus

9031:PRIMPOL
gene id: 9031:PRIMPOL
uniprot id: Q5F3K7
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9031:MTFR2
gene id: 9031:MTFR2
uniprot id: E1BWR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9031:TMEM121
gene id: 9031:TMEM121
uniprot id: Q8QFN3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM121 family.
messages: Expressed in the cardiac crescent and later in the myocardium in stages 4 to 25.
messages: May play a role in MAPK signaling.
messages: Membrane

9031:ACTC1
gene id: 9031:ACTC1
uniprot id: P68034
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9031:RAB19
gene id: 9031:RAB19
uniprot id: F1P278
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane

9031:JAKMIP2
gene id: 9031:JAKMIP2
uniprot id: A0A8V0YME3
uniprot id: A0A8V0YUH7
uniprot id: A0A8V0YUJ2
uniprot id: E1BZS6
names: Similarity
messages: Belongs to the JAKMIP family.

9031:PSMC3
gene id: 9031:PSMC3
uniprot id: Q5ZIT7
names: Similarity
messages: Belongs to the AAA ATPase family.

9031:OPN5
gene id: 9031:OPN5
uniprot id: B3XZF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:GMNN
gene id: 9031:GMNN
uniprot id: A0A8V0XR36
uniprot id: Q5ZKE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9031:BEST3
gene id: 9031:BEST3
uniprot id: E1C882
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

9031:FRG1BP
gene id: 9031:FRG1BP
uniprot id: E1BY86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9031:IFI6
gene id: 9031:IFI6
uniprot id: Q6IEC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9031:RBPMS2
gene id: 9031:RBPMS2
uniprot id: Q9W6I1
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in developing heart.
messages: Highly expressed in embryonic stomach, midgut and colon during the period of visceral smooth muscle cell differentiation; levels decrease rapidly thereafter (PubMed:22683258). mRNA already detected at stage 7-8 in the cardiogenic mesoderm, and become almost undetectable in the outer curvature of the ventricular region whereas remaining high in the developing atrial regions (PubMed:10096065).
messages: Homodimer.
messages: RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:22683258, PubMed:25064856). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway (PubMed:25064856). Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (PubMed:25064856).

9031:NATD1
gene id: 9031:NATD1
uniprot id: Q5ZJI6
names: Similarity
messages: Belongs to the NATD1 family.

9031:CCR8
gene id: 9031:CCR8
uniprot id: A0A1D5P622
uniprot id: Q5ZI02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9031:XPO7
gene id: 9031:XPO7
uniprot id: Q5ZLT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Mediates the nuclear export of proteins (cargos) with broad substrate specificity.
messages: Nucleus

9031:FAM163B
gene id: 9031:FAM163B
uniprot id: R4GL56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9031:DYNLT3
gene id: 9031:DYNLT3
uniprot id: E1BVZ7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9031:CDH19
gene id: 9031:CDH19
uniprot id: A6YJX3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane

9031:GOSR2
gene id: 9031:GOSR2
uniprot id: A0A8V1A9S7
names: Subcellular Location Annotation
messages: Membrane

9031:FGFR1OP2
gene id: 9031:FGFR1OP2
uniprot id: Q5ZKJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIKE family.
messages: Cytoplasm

9031:ACADL
gene id: 9031:ACADL
uniprot id: Q5ZJ93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

9031:CTBP1
gene id: 9031:CTBP1
uniprot id: Q5ZIZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9031:UTP6
gene id: 9031:UTP6
uniprot id: Q5ZI50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

9031:ARRDC1
gene id: 9031:ARRDC1
uniprot id: Q5ZKV5
names: Similarity
messages: Belongs to the arrestin family.

9031:GRAMD1C
gene id: 9031:GRAMD1C
uniprot id: A0A1D5PFV8
uniprot id: A0A8V0XT51
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:CSNK1E
gene id: 9031:CSNK1E
uniprot id: Q5ZLL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm (By similarity).
messages: Cytoplasm
messages: Monomer (By similarity). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1E, and the PER proteins (By similarity).

9031:VCAM1
gene id: 9031:VCAM1
uniprot id: F1P201
names: Subcellular Location Annotation
messages: Cell membrane

9031:SEC13
gene id: 9031:SEC13
uniprot id: A0A1D5NYF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane

9031:PVALB
gene id: 9031:PVALB
uniprot id: C1L370
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9031:ETV6
gene id: 9031:ETV6
uniprot id: A0A8V0ZUM0
uniprot id: F1NRC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:DNTT
gene id: 9031:DNTT
uniprot id: P36195
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Can also utilize other divalent cations, such as Mn(2+) and Co(2+) (in vitro).
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

9031:CTSE
gene id: 9031:CTSE
uniprot id: A0A8V1A722
names: Similarity
messages: Belongs to the peptidase A1 family.

9031:LOC769000
gene id: 9031:LOC769000
uniprot id: A0A1D5NUH3
uniprot id: A0A8V0YB95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9031:TNFRSF21
gene id: 9031:TNFRSF21
uniprot id: Q98SM6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:NXPH3
gene id: 9031:NXPH3
uniprot id: A0A8V1A0H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9031:KIF18B
gene id: 9031:KIF18B
uniprot id: Q5ZLK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Cytoplasm
messages: May play an important role in microtubule plus-end depolymerizing activity in mitotic cells.
messages: Nucleus
messages: cytoskeleton

9031:RBPJ
gene id: 9031:RBPJ
uniprot id: A0A3Q2UCS9
uniprot id: A0A8V0Y210
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9031:GJA1
gene id: 9031:GJA1
uniprot id: P14154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins. Interacts with TMEM65.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: In all tissues, but mostly in lens.
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles.
messages: gap junction

9031:PLPPR3
gene id: 9031:PLPPR3
uniprot id: A0A1D5PYJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9031:C12orf65
gene id: 9031:C12orf65
uniprot id: A0A1D5PY53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9031:PIK3R3
gene id: 9031:PIK3R3
uniprot id: A0A8V1A076
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9031:H2AFY
gene id: 9031:H2AFY
uniprot id: O93327
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ADP-ribosylated.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: In contrast to isoform 1, does not bind poly-ADP-ribose.
messages: Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism. Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them. This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration.
messages: Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.
messages: Nucleus
messages: Present in immature erythrocytes (at protein level).
messages: Present in liver (at protein level).
messages: The macro domain specifically binds poly-ADP-ribose.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

9031:ZDHHC17
gene id: 9031:ZDHHC17
uniprot id: Q5ZIM1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:FBF1
gene id: 9031:FBF1
uniprot id: Q5ZIB2
names: Function
names: Subcellular Location Annotation
messages: Cell junction
messages: Keratin-binding protein required for epithelial cell polarization. Required for ciliogenesis (By similarity).
messages: centriole
messages: spindle pole

9031:COX14
gene id: 9031:COX14
uniprot id: A0A8V1A933
names: Subcellular Location Annotation
messages: Membrane

9031:CRY2
gene id: 9031:CRY2
uniprot id: Q8QG60
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) non-covalently per subunit.
messages: Binds 1 FAD per subunit.
messages: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1E, and the PER proteins.
messages: Cytoplasm
messages: Exhibits some circadian rhythm expression. Levels increase slightly during subjective day peaking at 10 hours. Levels decrease between 14 hours and 18 hours to peak again at 20 hours-22 hours.
messages: Expressed in the pineal gland.
messages: Nucleus
messages: Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …

9031:LARGE2
gene id: 9031:LARGE2
uniprot id: Q66PG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 (By similarity). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity).
messages: Binds 2 Mn(2+) ions per subunit. The xylosyltransferase part binds one Mn(2+) and the beta-1,3-glucuronyltransferase part binds one Mn(2+).
messages: Golgi apparatus membrane
messages: In the C-terminal section; belongs to the glycosyltransferase 49 family.
messages: In the N-terminal section; belongs to the glycosyltransferase 8 family.

9031:MAPK8IP1
gene id: 9031:MAPK8IP1
uniprot id: A0A8V0ZG48
uniprot id: A0A8V0ZNM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JIP scaffold family.
messages: Cytoplasm

9031:CNOT10
gene id: 9031:CNOT10
uniprot id: Q5ZIW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).
messages: Component of the CCR4-NOT complex. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold (By similarity).
messages: Cytoplasm
messages: Nucleus

9031:OR6B1
gene id: 9031:OR6B1
uniprot id: O57597
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:EMC8
gene id: 9031:EMC8
uniprot id: F1N8E6
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9031:USP20
gene id: 9031:USP20
uniprot id: A0A8V1AGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: centrosome
messages: perinuclear region

9031:VWA9
gene id: 9031:VWA9
uniprot id: Q5ZK21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9031:WNT7A
gene id: 9031:WNT7A
uniprot id: Q9DEB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:ETV5
gene id: 9031:ETV5
uniprot id: F1NEG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:NOX1
gene id: 9031:NOX1
uniprot id: A7E3K3
names: Subcellular Location Annotation
messages: Membrane

9031:EIF5A2
gene id: 9031:EIF5A2
uniprot id: A0A1B1XXT1
uniprot id: Q07460
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-5A family.
messages: Binds to 80S ribosomes. Actively translating ribosomes show mutually exclusive binding of eIF5a (EIF5A or EIF5A2) and EEF2/eEF2 (By similarity). Interacts with DAPL1; interaction takes place at the polypeptide exit tunnel of hibernating ribosomes and prevents translation (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Lys-50 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain and leads to the formation of a hypusine residue. eIF-5As are the only known proteins to undergo this modification, which is essential for their function.
messages: Membrane
messages: Nucleus
messages: The N-terminus is blocked.
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity).
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

9031:IMPACT
gene id: 9031:IMPACT
uniprot id: A0A8V0XLX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

9031:WIPI2
gene id: 9031:WIPI2
uniprot id: Q5ZHN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures.
messages: Preautophagosomal structure membrane
messages: The L/FRRG motif is required for recruitment to PtdIns3P.

9031:PDCL3
gene id: 9031:PDCL3
uniprot id: Q5ZL90
names: Similarity
messages: Belongs to the phosducin family.

9031:GDI1
gene id: 9031:GDI1
uniprot id: O93382
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9031:ANXA5
gene id: 9031:ANXA5
uniprot id: P17153
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Collagen-binding protein.

9031:PRTFDC1
gene id: 9031:PRTFDC1
uniprot id: A0A8V0XLN3
uniprot id: E1C5K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9031:GEMIN2
gene id: 9031:GEMIN2
uniprot id: Q5ZJH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

9031:PPIL2
gene id: 9031:PPIL2
uniprot id: Q5ZJH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9031:SERPINH1
gene id: 9031:SERPINH1
uniprot id: P13731
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
messages: By heat shock.
messages: Endoplasmic reticulum lumen

9031:RHBDL3
gene id: 9031:RHBDL3
uniprot id: A0A8V1AE07
uniprot id: A0A8V1AJE5
uniprot id: A0A8V1AMX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9031:AK6
gene id: 9031:AK6
uniprot id: Q5F4A8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9031:GNAL
gene id: 9031:GNAL
uniprot id: E1BS74
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9031:CHP1
gene id: 9031:CHP1
uniprot id: Q5ZM44
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family. CHP subfamily.
messages: Calcium-binding or N-myristoylation are necessary for the Na(+)/H(+) exchange activities.
messages: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription. Acts as a negative regulator of the calcineurin/NFAT signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Endomembrane system
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Membrane
messages: Monomer.
messages: Nucleus
messages: Phosphorylated.
messages: cytoskeleton

9031:PLEKHO1
gene id: 9031:PLEKHO1
uniprot id: Q5F3C8
names: Function
names: PTM
names: Subcellular Location Annotation
messages: C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage.
messages: Cytoplasm
messages: Membrane
messages: Nucleus
messages: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).

9031:CAMK1D
gene id: 9031:CAMK1D
uniprot id: A0A8V0XQX1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:SSR1
gene id: 9031:SSR1
uniprot id: Q5ZM63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9031:LOC107052806
gene id: 9031:LOC107052806
uniprot id: A0A1D5P6V7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:ERP29
gene id: 9031:ERP29
uniprot id: P81628
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.
messages: Endoplasmic reticulum lumen
messages: Homodimer.

9031:TAF5
gene id: 9031:TAF5
uniprot id: Q5F3I7
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9031:HTR1B
gene id: 9031:HTR1B
uniprot id: D3Y1H8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1D.
messages: Membrane

9031:ARR3
gene id: 9031:ARR3
uniprot id: A4L9I7
names: Similarity
messages: Belongs to the arrestin family.

9031:TMOD1
gene id: 9031:TMOD1
uniprot id: Q91006
names: Subcellular Location Annotation
messages: cytoskeleton

9031:LOC426514
gene id: 9031:LOC426514
uniprot id: A0A1D5PRY8
uniprot id: H9L1Y4
names: Similarity
messages: Belongs to the HARBI1 family.

9031:FABP5
gene id: 9031:FABP5
uniprot id: Q5ZIR7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9031:YTHDF3
gene id: 9031:YTHDF3
uniprot id: Q5ZLM1
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9031:MPI
gene id: 9031:MPI
uniprot id: A0A1D5Q008
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9031:PITX2
gene id: 9031:PITX2
uniprot id: O93385
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis.
messages: Nucleus

9031:MSI1
gene id: 9031:MSI1
uniprot id: A0A8V0ZCA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm

9031:TPST2
gene id: 9031:TPST2
uniprot id: Q5ZJI0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane
messages: Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding cleft.

9031:SEMA5A
gene id: 9031:SEMA5A
uniprot id: A0A1D5PFR3
uniprot id: R4GFU3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ARL6IP5
gene id: 9031:ARL6IP5
uniprot id: Q5F433
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA1 family.
messages: Binds to prenylated RAB and Ras superfamily members.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic.
messages: cytoskeleton

9031:LHX3
gene id: 9031:LHX3
uniprot id: P53412
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed prior to the formation of distinct motor axon pathways and before the segregation of motor neurons into columns. Expression restricted to the medial subdivision of the median motor column (MMCm).
messages: Nucleus
messages: Transcription factor (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2.

9031:HSD17B4
gene id: 9031:HSD17B4
uniprot id: A0A1D5NWL9
uniprot id: O42484
names: Subcellular Location Annotation
messages: Peroxisome

9031:LSM1
gene id: 9031:LSM1
uniprot id: A0A8V0Z4N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Probably involved with other LSm subunits in the general process of degradation of mRNAs.

9031:MMD
gene id: 9031:MMD
uniprot id: Q5ZKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9031:TMEM198
gene id: 9031:TMEM198
uniprot id: A0A8V0ZGW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9031:TMEM255B
gene id: 9031:TMEM255B
uniprot id: A0A1D5PFG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9031:CEBPG
gene id: 9031:CEBPG
uniprot id: Q98944
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

9031:MPC2
gene id: 9031:MPC2
uniprot id: F1NU06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9031:IGF1
gene id: 9031:IGF1
uniprot id: C5J073
uniprot id: P18254
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.

9031:SLC30A4
gene id: 9031:SLC30A4
uniprot id: E1C7N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9031:SLC2A11L4
gene id: 9031:SLC2A11L4
uniprot id: F1P492
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:MAT2L
gene id: 9031:MAT2L
uniprot id: E1C7X8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9031:STAR
gene id: 9031:STAR
uniprot id: Q9DG09
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed principally in steroidogenic tissues as ovary (granulosa from the largest preovulatory follicle and stromal tissues) and adrenals.
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).

9031:STARD3NL
gene id: 9031:STARD3NL
uniprot id: A0A1L1RKF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Membrane

9031:TPM2
gene id: 9031:TPM2
uniprot id: A0A8V0YB91
uniprot id: A0A8V0YFX2
uniprot id: P19352
uniprot id: Q05705
uniprot id: Q05706
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
messages: Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

9031:LOC121106449
gene id: 9031:LOC121106449
uniprot id: E1C781
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:LOC768760
gene id: 9031:LOC768760
uniprot id: B0Z662
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9031:LOC776273
gene id: 9031:LOC776273
uniprot id: A0A8V0Y6G0
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9031:TCEA1
gene id: 9031:TCEA1
uniprot id: Q5ZHQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9031:EZH1
gene id: 9031:EZH1
uniprot id: A0A8V0ZGY2
names: Subcellular Location Annotation
messages: Nucleus

9031:BAK1
gene id: 9031:BAK1
uniprot id: Q5F404
names: Similarity
messages: Belongs to the Bcl-2 family.

9031:RREB1
gene id: 9031:RREB1
uniprot id: O57415
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Broadly expressed, except in brain.
messages: Nucleus
messages: Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters.

9031:RNF20
gene id: 9031:RNF20
uniprot id: F1N9A6
uniprot id: Q5ZLS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively).
messages: Component of the RNF20/40 complex (also known as BRE1 complex).
messages: Nucleus

9031:PLBD2
gene id: 9031:PLBD2
uniprot id: A0A8V0X7D0
uniprot id: F1P0Z3
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9031:TDO2
gene id: 9031:TDO2
uniprot id: A0A8V0XY50
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:LOC100859039
gene id: 9031:LOC100859039
uniprot id: A0A1D5P312
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:LOC107055267
gene id: 9031:LOC107055267
uniprot id: A0A8V1A6H4
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:LYSMD3
gene id: 9031:LYSMD3
uniprot id: Q5ZKK0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Essential for Golgi structural integrity.
messages: Golgi apparatus

9031:VIL1
gene id: 9031:VIL1
uniprot id: P02640
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the villin/gelsolin family.
messages: Consists of a large core fragment in the N-terminal portion and a small headpiece (HP) in the C-terminal portion. The core fragment is necessary for both actin-nucleating and -severing activities, whereas the HP binds F-actin strongly in both the presence and absence of calcium and is necessary in actin-bundling activity. The Gelsolin-like 1 repeat is necessary for the actin-capping activity. The entire core fragment is necessary for the actin-severing activity (By similarity).
messages: Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). Its actin-bundling activity is inhibited by tropomyosin.
messages: Monomer. Homodimer (By similarity). Associates with F-actin; the association with F-actin is inhibited by tropomyosin.
messages: Phosphorylated on tyrosine residues. The unphosphorylated form increases the initial rate of actin-nucleating activity, whereas the tyrosine-phosphorylated form inhibits actin-nucleating activity, enhances actin-bundling activity and enhances actin-severing activity by reducing high Ca(2+) requirements. The tyrosine-phosphorylated form does not regulate actin-capping activity. Tyrosine phosphorylation is essential for cell migration: tyrosine phosphorylation sites in the N-terminus half regulate actin reorganization and cell morphology, whereas tyrosine phosphorylation sites in the C-terminus half regulate cell migration. Tyrosine phosphorylation is induced by epidermal growth factor (EGF) and stimulates cell migration (By similarity).
messages: Specifically expressed in epithelial cells. Component of brush border microvilli.
messages: cytoskeleton
messages: filopodium
messages: filopodium tip
messages: lamellipodium
messages: microvillus
messages: ruffle

9031:ZFYVE28
gene id: 9031:ZFYVE28
uniprot id: A0A8V0YVC2
uniprot id: A0A8V0Z992
names: Similarity
messages: Belongs to the lst-2 family.

9031:TBCCD1
gene id: 9031:TBCCD1
uniprot id: Q5ZKT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: May play a role in the regulation of centrosome and Golgi apparatus positioning.
messages: centrosome
messages: spindle pole

9031:NFXL1
gene id: 9031:NFXL1
uniprot id: E1C027
names: Similarity
messages: Belongs to the NFX1 family.

9031:TMEM206
gene id: 9031:TMEM206
uniprot id: A0A1D5PH61
uniprot id: A0A1D5PSZ0
uniprot id: A0A8V0ZH83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9031:ATG101
gene id: 9031:ATG101
uniprot id: A0A8V1A5H9
names: Similarity
messages: Belongs to the ATG101 family.

9031:LOC419429
gene id: 9031:LOC419429
uniprot id: A0A1L1RU24
uniprot id: A0A8V0ZLS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9031:CHAF1B
gene id: 9031:CHAF1B
uniprot id: Q5R1S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat HIR1 family.
messages: Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
messages: Interacts with CHAF1A.
messages: Nucleus

9031:NACC2
gene id: 9031:NACC2
uniprot id: Q5ZI70
names: Subcellular Location Annotation
messages: Nucleus

9031:MAB21L3
gene id: 9031:MAB21L3
uniprot id: A0A8V1A2Q3
names: Similarity
messages: Belongs to the mab-21 family.

9031:ATP5G1
gene id: 9031:ATP5G1
uniprot id: A0A8V1AAX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9031:MALRD1
gene id: 9031:MALRD1
uniprot id: R9W6V6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ATP2A2
gene id: 9031:ATP2A2
uniprot id: A0A1L1RKB7
uniprot id: Q03669
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN). Interacts with DWORF (By similarity). Interacts with TMX2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Only isoform 2 is detected in heart, while both isoforms are expressed in brain, with isoform 2 being predominant.
messages: PLN and SLN both have a single transmembrane helix; both occupy a similar binding site that is situated between the ATP2A2 transmembrane helices.
messages: Reversibly inhibited by phospholamban (PLN) at low calcium concentrations (By similarity). Inhibited by sarcolipin (SLN) and myoregulin (MRLN) (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. May act as a regulator of TNFSF11-mediated Ca(2+) signaling during osteoclastogenesis.

9031:SOX9
gene id: 9031:SOX9
uniprot id: P48434
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: By BMP2 during chondrogenesis.
messages: Found in chondrogenic regions in the branchial arches, somites and limb buds at 22 dpc. At 28 dpc detected in the limbs, developing scapula, prevertebrae and ribs. Found in condensing mesenchyme of the forelimb at 25 dpc. Expressed in the condensing mesenchyme at the distal tips of the developing hindlimbs at 26 dpc.
messages: Interacts with SNAI2; triggers neural crest delamination in a phosphorylation dependent manner. Interacts with UBE2I.
messages: Nucleus
messages: Phosphorylated at Ser-181 in the developing neural tube. Phosphorylation at either Ser-64 or Ser-181 is required for sumoylation, but phosphorylation is not dependent on sumoylation. Sumoylation is enhanced by PKA. Phosphorylation is required for interaction with SNAI2 to trigger neural crest delamination and for an efficient trunk neural crest delamination, whereas sumoylation plays a less significant role. Phosphorylation and sumoylation are induced by BMP signaling pathway.
messages: Sumoylated at Lys-376; phosphorylation at either Ser-64 or Ser-181 is required for sumoylation. Sumoylation is induced by BMP signaling pathway.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:10340758, PubMed:9858536). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including COL2A1 (PubMed:10340758, PubMed:9858536). Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells (By similarity). In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination (PubMed:23382206).

9031:ADRM1
gene id: 9031:ADRM1
uniprot id: Q98SH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ADRM1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor.
messages: Cytoplasm
messages: Nucleus

9031:GRIK1
gene id: 9031:GRIK1
uniprot id: A0A8V0YE44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:SLC16A14
gene id: 9031:SLC16A14
uniprot id: E1C1Q8
names: Subcellular Location Annotation
messages: Membrane

9031:MB21D2
gene id: 9031:MB21D2
uniprot id: E1C397
names: Similarity
messages: Belongs to the mab-21 family.

9031:SEMA3F
gene id: 9031:SEMA3F
uniprot id: Q8QGU9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:STK39
gene id: 9031:STK39
uniprot id: A0A8V1A7M0
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9031:CCNL1
gene id: 9031:CCNL1
uniprot id: A0A8V0X2N2
names: Similarity
messages: Belongs to the cyclin family.

9031:FDX1
gene id: 9031:FDX1
uniprot id: P13216
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenodoxin/putidaredoxin family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons.
messages: Mitochondrion matrix

9031:FAM98A
gene id: 9031:FAM98A
uniprot id: Q5ZMB0
names: Similarity
messages: Belongs to the FAM98 family.

9031:TFPI2
gene id: 9031:TFPI2
uniprot id: A0A3Q3A7D8
names: Subcellular Location Annotation
messages: Secreted

9031:POU1F1
gene id: 9031:POU1F1
uniprot id: O57599
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9031:LOC428720
gene id: 9031:LOC428720
uniprot id: A0A3Q2UGZ3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:VGLL4
gene id: 9031:VGLL4
uniprot id: F1NEM0
uniprot id: R4GG38
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

9031:NTN4L
gene id: 9031:NTN4L
uniprot id: F1P486
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GOT1
gene id: 9031:GOT1
uniprot id: P00504
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
messages: Cytoplasm
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9031:IKZF1
gene id: 9031:IKZF1
uniprot id: O42410
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Ikaros C2H2-type zinc-finger protein family.
messages: Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity).
messages: Expressed early in embryo from embryonic day 2 onwards.
messages: Expressed in embryonic hematopoietic organs such as the bursa of Fabricius, thymus and spleen. In the adult, expressed in spleen, thymus, bursa and peripheral blood leukocytes.
messages: Nucleus

9031:UQCC1
gene id: 9031:UQCC1
uniprot id: Q5ZIZ3
names: Similarity
messages: Belongs to the CBP3 family.

9031:RTCB
gene id: 9031:RTCB
uniprot id: F1NYI3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9031:GK5
gene id: 9031:GK5
uniprot id: Q5ZMJ4
names: Similarity
messages: Belongs to the FGGY kinase family.

9031:WDR48
gene id: 9031:WDR48
uniprot id: Q5F3K4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Cytoplasm
messages: Late endosome
messages: Lysosome
messages: Nucleus
messages: Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme. Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes.Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress.
messages: The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46.

9031:ARPC1A
gene id: 9031:ARPC1A
uniprot id: Q5ZJI7
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9031:COPG1
gene id: 9031:COPG1
uniprot id: Q5F402
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9031:CPE
gene id: 9031:CPE
uniprot id: R4GFJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Membrane
messages: secretory vesicle membrane

9031:FGFR2
gene id: 9031:FGFR2
uniprot id: A0A8V0X2A5
uniprot id: A0A8V0XB30
uniprot id: A0A8V0XB42
uniprot id: P18461
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Membrane
messages: Monomer. Homodimer after ligand binding (By similarity).
messages: N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus (By similarity).
messages: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans.
messages: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity).
messages: Ubiquitinated. FGFR2 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation. Subject to degradation both in lysosomes and by the proteasome (By similarity).

9031:TLN2
gene id: 9031:TLN2
uniprot id: A0A8V0ZT95
names: Subcellular Location Annotation
messages: cytoskeleton

9031:GATAD2A
gene id: 9031:GATAD2A
uniprot id: A0A1D5PFQ6
uniprot id: A0A1D5PG96
uniprot id: Q5F328
names: Subcellular Location Annotation
messages: Nucleus

9031:CHST3
gene id: 9031:CHST3
uniprot id: Q92179
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Golgi apparatus membrane
messages: N-glycosylated.
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin (PubMed:7629189). Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (PubMed:7629189). Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan (PubMed:7629189). Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (PubMed:9147050).

9031:PIK3CA
gene id: 9031:PIK3CA
uniprot id: O42391
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:TFF3
gene id: 9031:TFF3
uniprot id: E1BZ37
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:VIPR2
gene id: 9031:VIPR2
uniprot id: Q56IA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9031:HNF4beta
gene id: 9031:HNF4beta
uniprot id: Q5ILG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9031:LECT2
gene id: 9031:LECT2
uniprot id: F1NEF7
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9031:RAB2A
gene id: 9031:RAB2A
uniprot id: Q90965
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Interacts with PRKCI. Interacts with TRIP11 (By similarity). Interacts (in GTP-bound form) with GARIN1B (By similarity).
messages: Melanosome
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology.
messages: acrosome

9031:UBE2R2L
gene id: 9031:UBE2R2L
uniprot id: R4GIV8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:TRMT11
gene id: 9031:TRMT11
uniprot id: Q6YJI5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

9031:FAM206A
gene id: 9031:FAM206A
uniprot id: Q5ZHW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons.
messages: Belongs to the ABITRAM family.
messages: Nucleus
messages: Nucleus speckle
messages: dendrite
messages: growth cone
messages: lamellipodium

9031:TIMP2
gene id: 9031:TIMP2
uniprot id: O42146
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
messages: Secreted
messages: The activity of TIMP2 is dependent on the presence of disulfide bonds.

9031:FNIP2
gene id: 9031:FNIP2
uniprot id: A0A3Q2U512
uniprot id: A0A8V0Y3U1
uniprot id: F1NVA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9031:CLSPN
gene id: 9031:CLSPN
uniprot id: A0A8V0YSE4
uniprot id: D2XSJ5
names: Subcellular Location Annotation
messages: Nucleus

9031:HRH2
gene id: 9031:HRH2
uniprot id: A0A3Q2TUM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:WNT3A
gene id: 9031:WNT3A
uniprot id: Q2LMP1
names: Caution
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A palmitoylation site was proposed at Cys-77, but it was later shown that this cysteine is engaged in a disulfide bond.
messages: Belongs to the Wnt family.
messages: Cytoplasm
messages: Disulfide bonds have critical and distinct roles in secretion and activity. Loss of each conserved cysteine in WNT3A results in high molecular weight oxidized Wnt oligomers, which are formed through inter-Wnt disulfide bonding (By similarity).
messages: Expressed in cornea. Isoform 1 is expressed in the primitive streak, dorsal neural tube, proximal otic vesicle, the apical ectodermal ridge and the epithelium of feather buds.
messages: In the eye, the expression was observed at stage 23 in the ocular surface epithelium ventral to the corneal epithelium. Strongly expressed in the entire ocular surface at stage 26 including the corneal epithelium. Remained strongly expressed at stage 30.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:17488271). Regulates chick apical ectodermal ridge formation (PubMed:17488271). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity).
messages: Not secreted.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors (PubMed:22046319). Depalmitoleoylation leads to inhibit the Wnt signaling pathway (By similarity).
messages: Secreted
messages: extracellular matrix

9031:NDNF
gene id: 9031:NDNF
uniprot id: F1NIF2
names: Subcellular Location Annotation
messages: Secreted

9031:TGM3
gene id: 9031:TGM3
uniprot id: A0A1D5NXS5
uniprot id: A0A8V0ZXT6
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9031:CNTN2
gene id: 9031:CNTN2
uniprot id: P28685
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Axon-associated cell adhesion molecule (AxCAM) which promotes neurite outgrowth by interaction with the AxCAM L1 (G4) of neuritic membrane. Contributes to the organization of axonal domains at nodes of Ranvier (By similarity).
messages: Belongs to the immunoglobulin superfamily. Contactin family.
messages: Cell membrane
messages: The N-terminus is blocked.

9031:GCH1
gene id: 9031:GCH1
uniprot id: P50141
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Cytoplasm
messages: GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity. Zinc is required for catalytic activity. Inhibited by Mg(2+).
messages: May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence.
messages: Nucleus
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

9031:NPY1R
gene id: 9031:NPY1R
uniprot id: Q8QFM1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:RDH10
gene id: 9031:RDH10
uniprot id: A0A1D5PLZ3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:DNAH7
gene id: 9031:DNAH7
uniprot id: A0A8V0Y8G8
names: Similarity
messages: Belongs to the dynein heavy chain family.

9031:FOXN4
gene id: 9031:FOXN4
uniprot id: A3EYS4
names: Subcellular Location Annotation
messages: Nucleus

9031:ETS1
gene id: 9031:ETS1
uniprot id: G9LQW2
uniprot id: G9LQW3
uniprot id: P13474
uniprot id: P15062
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoinhibited by a module composed of four alpha helices (HI-1, HI-2, H4, and H5) that flank the DNA-binding ETS domain, reducing the affinity for DNA.
messages: Belongs to the ETS family.
messages: Binds DNA as a homodimer; homodimerization is required for transcription activation.
messages: Cytoplasm
messages: Nucleus
messages: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts.

9031:LUC7L
gene id: 9031:LUC7L
uniprot id: A0A8V0Z0F5
names: Similarity
messages: Belongs to the Luc7 family.

9031:PRKCD
gene id: 9031:PRKCD
uniprot id: A0A1D5PXN4
uniprot id: Q5ZKE2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

9031:PHAF1
gene id: 9031:PHAF1
uniprot id: Q5ZKM4
names: Similarity
messages: Belongs to the PHAF1 family.

9031:TRIM105
gene id: 9031:TRIM105
uniprot id: A0A8V0YXT2
names: Subcellular Location Annotation
messages: Cytoplasm

9031:TICAM1
gene id: 9031:TICAM1
uniprot id: A0FKC7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.
messages: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
messages: Mitochondrion
messages: The N-terminal region is essential for activation of the IFNB promoter activity.
messages: autophagosome
messages: cytosol

9031:GALR1L
gene id: 9031:GALR1L
uniprot id: B2CNR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:SIX3
gene id: 9031:SIX3
uniprot id: O42406
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: First detected in the corneal epithelium and lens epithelium at 6.5 dpc and 12 dpc. At 12 dpc is present in the corneal endothelium and the limbal region. After 16 dpc and at hatching (H1), expression persisted in multiple anterior segment tissues, including the lens epithelium, the corneal endothelium, the iris, and the trabecular meshwork (at protein level).
messages: Nucleus
messages: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon (PubMed:12569128). Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner (PubMed:12050133). Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway. Plays a role i…

9031:KIF5C
gene id: 9031:KIF5C
uniprot id: F1NE00
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:STX2
gene id: 9031:STX2
uniprot id: A0A1D5PY18
uniprot id: A0A8V0ZR60
names: Similarity
messages: Belongs to the syntaxin family.

9031:PAQR7
gene id: 9031:PAQR7
uniprot id: C6KGD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9031:STARD3
gene id: 9031:STARD3
uniprot id: A0A1D5PID8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9031:NTMT1
gene id: 9031:NTMT1
uniprot id: H9L0S2
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9031:IRF2
gene id: 9031:IRF2
uniprot id: Q98925
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IRF family.
messages: Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity.
messages: Nucleus
messages: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation (By similarity).

9031:PRRT1B
gene id: 9031:PRRT1B
uniprot id: A0A8V1AFR5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9031:PHKG1
gene id: 9031:PHKG1
uniprot id: A0A8V1AJR9
uniprot id: Q5ZJ45
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9031:UBAC2
gene id: 9031:UBAC2
uniprot id: Q5ZJQ8
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). May negatively regulate the canonical Wnt signaling pathway in the lymphocytes (By similarity).

9031:CDR2L
gene id: 9031:CDR2L
uniprot id: R4GIU8
names: Similarity
messages: Belongs to the CDR2 family.

9031:BMP5
gene id: 9031:BMP5
uniprot id: P87373
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9031:SGMS1
gene id: 9031:SGMS1
uniprot id: Q7T3T4
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Golgi apparatus membrane
messages: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide (By similarity).
messages: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.

9031:OSBPL2
gene id: 9031:OSBPL2
uniprot id: Q5ZLC4
names: Similarity
messages: Belongs to the OSBP family.

9031:TPD52L2
gene id: 9031:TPD52L2
uniprot id: Q5ZI93
names: Similarity
messages: Belongs to the TPD52 family.

9031:HDX
gene id: 9031:HDX
uniprot id: Q5ZKW8
names: Subcellular Location Annotation
messages: Nucleus

9031:UGP2
gene id: 9031:UGP2
uniprot id: A0A1D5P0A1
uniprot id: Q5ZKW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9031:TAP2
gene id: 9031:TAP2
uniprot id: A5HUM1
names: Subcellular Location Annotation
messages: Membrane

9031:NDRG4
gene id: 9031:NDRG4
uniprot id: A0A8V0ZRI4
uniprot id: A0A8V0ZRI9
names: Similarity
messages: Belongs to the NDRG family.

9031:GLO1
gene id: 9031:GLO1
uniprot id: A0A1L1RZK1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9031:NFKB1
gene id: 9031:NFKB1
uniprot id: Q04861
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Active NF-kappa-B is a heterodimer of an about 50 kDa DNA-binding subunit and the weak DNA-binding subunit p65. Two heterodimers might form a labile tetramer.
messages: Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor. Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions.
messages: Cytoplasm
messages: Generation of the NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) transcription factor takes place both cotranslationally and post-translationally via non-mutually exclusive mechanisms. A cotranslational processing allows the production of both p50 and p105 (Nuclear factor NF-kappa-B p105 subunit) from a single NFKB1 mRNA. While translation occurs, the particular unfolded structure after the GRR repeat region acts as a substrate for the proteasome, promoting degradation of the C-terminus. The GRR acts as a proteasomal 'stop signal', protecting the region upstream of the GRR from degradation and promoting generation of p50. It is unclear if limited proteasome degradation during cotranslational processing depends on ubiquitination. NF-kappa-B p50 is also generated post-translationally following ubiquitination by the KPC complex, leading to limited processing by the proteasome downstream of the GRR region, thereby generating p50.
messages: Glycine-rich region (GRR) is a critical element in the generation of p50 (Nuclear factor NF-kappa-B p50 subunit) by acting as a proteasomal 'stop signal', which leads to limited proteasomal degradation of the C-terminus, while generating p50.
messages: Nucleus
messages: P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B. The precursor protein itself does not bind to DNA. Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105.
messages: Phosphorylation at the C-terminus by IKBKB/IKKB acts as a signal for ubiquitination and promotes either complete degradation or processing to generate the NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) (By similarity). Phosphorylation at Ser-938 are required for BTRC/BTRCP-mediated ubiquitination and proteolysis (By similarity). Phosphorylation at Ser-938 is also required for ubiquitination by the KPC complex and limited processing to generate NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit) (By similarity).
messages: Polyubiquitinated at multiple Lys residues in the C-terminus. Polyubiquitinated by the SCF(FBXW11) and SCF(BTRC) complexes following phosphorylation at Ser-938, leading to its complete degradation. In contrast, polyubiquitination by the KPC complex following phosphorylation at Ser-938 leads to limited proteosomal processing and generation of the active NF-kappa-B p50 (Nuclear factor NF-kappa-B p50 subunit).
messages: S-nitrosylation of Cys-66 affects DNA binding.
messages: The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation.
messages: The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation.

9031:MIB2
gene id: 9031:MIB2
uniprot id: Q5ZIJ9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

9031:CHIA
gene id: 9031:CHIA
uniprot id: Q8AV87
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9031:STARD5
gene id: 9031:STARD5
uniprot id: F1NPH6
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9031:FOXB1
gene id: 9031:FOXB1
uniprot id: A0A8V0ZZC0
names: Subcellular Location Annotation
messages: Nucleus

9031:MMP1
gene id: 9031:MMP1
uniprot id: E1C9D9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9031:ADAM12
gene id: 9031:ADAM12
uniprot id: B8XA31
uniprot id: D6R189
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:NTHL1
gene id: 9031:NTHL1
uniprot id: A0A8V0Z483
uniprot id: A7M7B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Mitochondrion
messages: Nucleus

9031:PHC1
gene id: 9031:PHC1
uniprot id: Q5ZKD2
names: Subcellular Location Annotation
messages: Nucleus

9031:ATP4B
gene id: 9031:ATP4B
uniprot id: Q07420
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9031:PRKAB2
gene id: 9031:PRKAB2
uniprot id: Q156C5
uniprot id: Q156C7
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9031:AMPD3
gene id: 9031:AMPD3
uniprot id: A0A8V0ZAB9
uniprot id: F1NG97
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9031:GAP43
gene id: 9031:GAP43
uniprot id: P35001
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neuromodulin family.
messages: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Cell membrane
messages: Expressed in neurons.
messages: First expressed in the body and head at embryonic stage 3 dpc (PubMed:2153895). Expressed in the mid-thoracic region of embryos and also in the spinal cord, dorsal root and sympathetic ganglia at embryonic stage 10 dpc (PubMed:2153895). Highly expressed in the brain at embryonic stage 13 dpc (PubMed:2153895). Expressed at low levels in the gut at embryonic stage 16 dpc (PubMed:2153895). Not expressed in heart, skeletal muscle or liver at embryonic stage 16 dpc (PubMed:2153895).
messages: Palmitoylated (PubMed:9813098). Palmitoylation is essential for plasma membrane association (PubMed:9813098).
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
messages: filopodium membrane
messages: growth cone membrane

9031:GNA13
gene id: 9031:GNA13
uniprot id: A0A1D5PQE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9031:RLBP1
gene id: 9031:RLBP1
uniprot id: E1C1U1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DEGS1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.

9031:DRC1
gene id: 9031:DRC1
uniprot id: F1NGP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC1 family.
messages: cilium axoneme
messages: flagellum axoneme

9031:TARDBP
gene id: 9031:TARDBP
uniprot id: Q5ZLN5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus
messages: Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity (By similarity).
messages: Stress granule
messages: The RRM domains can bind to both DNA and RNA.

9031:POLR1C
gene id: 9031:POLR1C
uniprot id: A0A1D5PP80
uniprot id: A0A8V0Y760
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9031:POLR2B
gene id: 9031:POLR2B
uniprot id: Q5ZMN9
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9031:BAMBI
gene id: 9031:BAMBI
uniprot id: E1AWU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9031:TMEM242
gene id: 9031:TMEM242
uniprot id: A0A8V0XU67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9031:ADAM23
gene id: 9031:ADAM23
uniprot id: A0A8V1A903
uniprot id: A0A8V1ADZ2
uniprot id: F1NYC6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PSMD12
gene id: 9031:PSMD12
uniprot id: Q5ZI37
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9031:TFAP2C
gene id: 9031:TFAP2C
uniprot id: E1C5K7
names: Similarity
messages: Belongs to the AP-2 family.

9031:EEF2KMT
gene id: 9031:EEF2KMT
uniprot id: Q5ZIM0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

9031:IHH
gene id: 9031:IHH
uniprot id: Q98938
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the hedgehog family.
messages: Binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain.
messages: Cell membrane
messages: Cholesterylation is required for N-product targeting to lipid rafts and multimerization.
messages: Endoplasmic reticulum membrane
messages: Expressed in developing midgut, lung and cartilage of developing long bones in the limb.
messages: Golgi apparatus membrane
messages: Interacts with BOC and CDON. Interacts with PTCH1 (By similarity). Interacts with glypican GPC3 (By similarity).
messages: Multimer.
messages: N-palmitoylation by HHAT of N-product is required for indian hedgehog protein N-product multimerization and full activity.
messages: Secreted
messages: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). The N-product is the active species in both local and long-range signaling, whereas the C-product is degraded in the reticulum endoplasmic (By similarity).
messages: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity).
messages: The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton. Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy. In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway (PubMed:8662546).

9031:TCF12
gene id: 9031:TCF12
uniprot id: P30985
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Abundantly expressed during development of the central nervous system, in particular in proliferating neuroblasts and in cells at the initial stages of differentiation. Also expressed at high levels in morphogenetically active regions such as limb buds, somites and mesonephric tubules. Expression decreases once cellular differentiation is over.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin, E12 and ITF2 proteins (By similarity).
messages: Nucleus
messages: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box-containing promoter (By similarity).

9031:IRF8
gene id: 9031:IRF8
uniprot id: Q90871
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system (By similarity).

9031:TSSC4
gene id: 9031:TSSC4
uniprot id: Q5ZJS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TSSC4 family.
messages: Cytoplasm
messages: Nucleus

9031:XRCC6
gene id: 9031:XRCC6
uniprot id: O93257
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ku70 family.
messages: Chromosome
messages: Heterodimer composed of XRCC5/Ku80 and XRCC6/Ku70. Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF. Additional component of the NHEJ complex includes PAXX. Following autophosphorylation, PRKDC dissociates from DNA, leading to formation of the short-range NHEJ complex, composed of LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF.
messages: Nucleus
messages: Phosphorylated on serine residues.
messages: Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection. Binding to DNA may be mediated by XRCC6. The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (By similarity).

9031:STMN1
gene id: 9031:STMN1
uniprot id: P31395
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the stathmin family.
messages: Binds to two alpha/beta-tubulin heterodimers.
messages: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity).
messages: Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF (By similarity).
messages: cytoskeleton

9031:UTS2B
gene id: 9031:UTS2B
uniprot id: Q6Q273
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9031:BGN
gene id: 9031:BGN
uniprot id: E1BT96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9031:THAP5
gene id: 9031:THAP5
uniprot id: Q5ZHN5
names: Subcellular Location Annotation
messages: Nucleus

9031:TPH2
gene id: 9031:TPH2
uniprot id: Q6PKI7
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9031:RNF13
gene id: 9031:RNF13
uniprot id: Q90972
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By myostatin.
messages: E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:20015074). Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity).
messages: Endoplasmic reticulum membrane
messages: Expressed in skeletal muscle tissue during embryonic development and for 2 weeks after hatching; becomes undetectable 3 weeks after hatching (at protein level).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Nucleus inner membrane
messages: The RING-type zinc finger domain is required for E3 ligase activity and for promoting ER stress-induced JNK activation and apoptosis.
messages: Widely expressed (at protein level). Lowest levels in the liver, moderate levels in the heart, intestine and spleen, and high levels in skeletal muscle, kidney, proventriculus and brain. Also expressed in inner ear after noise exposure.

9031:HK2
gene id: 9031:HK2
uniprot id: Q8AYP7
names: Similarity
messages: Belongs to the hexokinase family.

9031:SHFM1
gene id: 9031:SHFM1
uniprot id: Q5ZJW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

9031:LMNB2
gene id: 9031:LMNB2
uniprot id: P14732
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
messages: Belongs to the intermediate filament family.
messages: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
messages: Nucleus lamina
messages: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.

9031:CDH10
gene id: 9031:CDH10
uniprot id: P79995
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
messages: Cell membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:FGFBP1
gene id: 9031:FGFBP1
uniprot id: A0A8V0Y5K2
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9031:PPP2R5E
gene id: 9031:PPP2R5E
uniprot id: F1NLM6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

9031:HSCB
gene id: 9031:HSCB
uniprot id: F1N857
names: Similarity
messages: Belongs to the HscB family.

9031:TAAR2
gene id: 9031:TAAR2
uniprot id: E1C0A1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:EMC2
gene id: 9031:EMC2
uniprot id: A0A3Q2UDL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

9031:MAD1L1
gene id: 9031:MAD1L1
uniprot id: E1BRU0
names: Similarity
messages: Belongs to the MAD1 family.

9031:NME1
gene id: 9031:NME1
uniprot id: F1N910
names: Similarity
messages: Belongs to the NDK family.

9031:PDGFA
gene id: 9031:PDGFA
uniprot id: Q90WK1
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9031:LPGAT1
gene id: 9031:LPGAT1
uniprot id: Q5ZKD0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9031:FGFR4
gene id: 9031:FGFR4
uniprot id: F1NCL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

9031:TVP23A
gene id: 9031:TVP23A
uniprot id: A0A1D5P6B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9031:PPARD
gene id: 9031:PPARD
uniprot id: F1NHW8
uniprot id: Q9I8W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:BBS7
gene id: 9031:BBS7
uniprot id: E1BXI4
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9031:NPBWR1
gene id: 9031:NPBWR1
uniprot id: A0A172PWX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:VSX1
gene id: 9031:VSX1
uniprot id: Q9IAL2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At stage 12, expressed throughout the invaginating optic vesicles and a subset of cells in the ventral spinal cord, presumably interneuron precursors. At stage 14, when the optic cup forms, expression is restricted to a subset of retinoblasts. At stage 15, expression along the ventral spinal and hindbrain intensifies and persists beyond stage 20.
messages: Belongs to the paired homeobox family.
messages: Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity).
messages: Nucleus
messages: Restricted to bipolar cells of the retina and spinal cord.

9031:DUT
gene id: 9031:DUT
uniprot id: Q5ZKJ3
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

9031:CYP2C23b
gene id: 9031:CYP2C23b
uniprot id: P20678
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By phenobarbital.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:HNRNPH1
gene id: 9031:HNRNPH1
uniprot id: Q6WNG8
names: Subcellular Location Annotation
messages: nucleoplasm

9031:CDH4
gene id: 9031:CDH4
uniprot id: P24503
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
messages: Cell membrane
messages: Detected only after some degree of neuronal differentiation has taken place and persists at least up to the newly hatched stage.
messages: Embryonic brain and neuronal retina.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:SEMA5B
gene id: 9031:SEMA5B
uniprot id: A0A1D5PWJ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:USP35
gene id: 9031:USP35
uniprot id: A0A3Q2UDW5
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:CASR
gene id: 9031:CASR
uniprot id: A0A8V0ZLX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:AvBD5
gene id: 9031:AvBD5
uniprot id: Q6IV26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Has bactericidal activity.
messages: Secreted
messages: Strong expression in the tongue and bone marrow. Low expression in the esophagus, trachea, lung, brain and ovary. Expressed in the ovarian stroma, but not in the ovarian follicles.

9031:NPLOC4
gene id: 9031:NPLOC4
uniprot id: A0A1L1RME9
names: Similarity
messages: Belongs to the NPL4 family.

9031:CPLX3
gene id: 9031:CPLX3
uniprot id: A9DA55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9031:EHD3
gene id: 9031:EHD3
uniprot id: Q5ZM17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9031:ARHGDIG
gene id: 9031:ARHGDIG
uniprot id: A0A8V0YRZ8
names: Similarity
messages: Belongs to the Rho GDI family.

9031:ABCD3
gene id: 9031:ABCD3
uniprot id: Q5F4B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9031:TMPRSS6
gene id: 9031:TMPRSS6
uniprot id: A0A8V0YWI1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SLC6A1
gene id: 9031:SLC6A1
uniprot id: E1BVF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:LOC428295
gene id: 9031:LOC428295
uniprot id: A0A8V1A6H4
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:IGFBP4
gene id: 9031:IGFBP4
uniprot id: Q801D7
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:BASP1
gene id: 9031:BASP1
uniprot id: P23614
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the BASP1 family.
messages: Developing tissues.
messages: May play a specific role in the development of tissues.
messages: cytoskeleton

9031:AGAP1
gene id: 9031:AGAP1
uniprot id: A0A8V0YG47
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9031:DAZL
gene id: 9031:DAZL
uniprot id: Q804A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM DAZ family.
messages: Cytoplasm
messages: RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (By similarity).

9031:NELFE
gene id: 9031:NELFE
uniprot id: A0A3Q2UGX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

9031:LASP1
gene id: 9031:LASP1
uniprot id: D2Z1L9
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9031:MRPL53
gene id: 9031:MRPL53
uniprot id: A0A1D5PKK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

9031:DBT
gene id: 9031:DBT
uniprot id: Q98UJ6
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

9031:TLR21
gene id: 9031:TLR21
uniprot id: Q5ZJ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9031:LYVE1
gene id: 9031:LYVE1
uniprot id: E1C9I1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TINAG
gene id: 9031:TINAG
uniprot id: E1BTI7
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:LPAR6
gene id: 9031:LPAR6
uniprot id: A0A8V0XKR5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:PLG
gene id: 9031:PLG
uniprot id: F1NWX6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

9031:ADAT2
gene id: 9031:ADAT2
uniprot id: F1P565
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9031:APMAP
gene id: 9031:APMAP
uniprot id: Q5ZIF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the strictosidine synthase family.
messages: Membrane

9031:RAD52
gene id: 9031:RAD52
uniprot id: A0A1D5NXF5
names: Similarity
messages: Belongs to the RAD52 family.

9031:TRAPPC4
gene id: 9031:TRAPPC4
uniprot id: Q5ZHS6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9031:TOP2A
gene id: 9031:TOP2A
uniprot id: O42130
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (By similarity). May play a role in the regulation of circadian rhythm (By similarity).
messages: Nucleus
messages: nucleolus
messages: nucleoplasm

9031:LEAP2
gene id: 9031:LEAP2
uniprot id: Q6QLQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

9031:BTG4
gene id: 9031:BTG4
uniprot id: E1C802
names: Similarity
messages: Belongs to the BTG family.

9031:MMP10
gene id: 9031:MMP10
uniprot id: E1C9E0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9031:LY86
gene id: 9031:LY86
uniprot id: Q90890
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By myb.
messages: Detected in the macrophage-like 10.4 cells.
messages: M-shaped tetramer of two CD180-LY86 heterodimers.
messages: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).
messages: extracellular space

9031:SLC26A6
gene id: 9031:SLC26A6
uniprot id: R4GKK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9031:GGNBP2
gene id: 9031:GGNBP2
uniprot id: A0A8V1AFJ3
uniprot id: Q6GVH4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.

9031:LOC100858444
gene id: 9031:LOC100858444
uniprot id: A0A1D5PJ64
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:PDE6B
gene id: 9031:PDE6B
uniprot id: F1NA42
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:MFGE8
gene id: 9031:MFGE8
uniprot id: E1C0K5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SH3BP5
gene id: 9031:SH3BP5
uniprot id: Q5ZK11
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9031:RCAN1
gene id: 9031:RCAN1
uniprot id: E1BUP1
names: Similarity
messages: Belongs to the RCAN family.

9031:SLCO1B3
gene id: 9031:SLCO1B3
uniprot id: G4XPB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9031:DRD1
gene id: 9031:DRD1
uniprot id: B8YLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:SCX
gene id: 9031:SCX
uniprot id: P59101
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At stage 21, expressed in leg buds in a superficial proximomedial domain, expression is enhanced by stage 23. By stage 29, expression is elaborated to include both leg and wing. By stage 35, expressed in all muscle-to-bone attachment sites. Expressed also in a wing aponeurosis, a tendinous element arranged in flattened bands, and in some of the flattened sheets of connective tissue associated with muscle.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Dimerizes and binds the E-box consensus sequence with E12.
messages: Expressed in the intersomitic, the superficial proximomedial limb mesenchyme and the subectodermal mesenchyme.
messages: Nucleus
messages: Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.

9031:PRDM5
gene id: 9031:PRDM5
uniprot id: A0A8V0XU14
names: Subcellular Location Annotation
messages: Nucleus

9031:SF3B4
gene id: 9031:SF3B4
uniprot id: H9L019
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9031:ZEB2
gene id: 9031:ZEB2
uniprot id: A0A0U4VU53
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9031:COQ5
gene id: 9031:COQ5
uniprot id: Q5ZLL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9031:PERPB
gene id: 9031:PERPB
uniprot id: R4GHW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9031:ADCY2
gene id: 9031:ADCY2
uniprot id: E1BX91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9031:SLC35B3
gene id: 9031:SLC35B3
uniprot id: F1P4W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9031:PYGB
gene id: 9031:PYGB
uniprot id: Q5ZME4
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9031:EPDR1
gene id: 9031:EPDR1
uniprot id: A0A8V0Z152
names: Similarity
messages: Belongs to the ependymin family.

9031:FEZ2
gene id: 9031:FEZ2
uniprot id: E1C6V5
names: Similarity
messages: Belongs to the zygin family.

9031:SLC24A1
gene id: 9031:SLC24A1
uniprot id: Q9IAL8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:10662833). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (By similarity).
messages: Cell membrane
messages: Retinal rods. Localizes to the inner segment of rod photoreceptors.
messages: The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration and topology.

9031:SF3B3
gene id: 9031:SF3B3
uniprot id: A0A1D6UPS9
names: Subcellular Location Annotation
messages: Nucleus

9031:PSMA1
gene id: 9031:PSMA1
uniprot id: O42265
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9031:GABRA2
gene id: 9031:GABRA2
uniprot id: F1NXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9031:PGRMC1
gene id: 9031:PGRMC1
uniprot id: Q5ZKN2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). May be required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.
messages: Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.
messages: Microsome membrane
messages: Mitochondrion outer membrane
messages: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
messages: Secreted
messages: Smooth endoplasmic reticulum membrane
messages: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 105 and 129.

9031:SH3RF1
gene id: 9031:SH3RF1
uniprot id: F1NYR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3RF family.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

9031:S100A6
gene id: 9031:S100A6
uniprot id: Q98953
names: Function
names: Similarity
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).

9031:DSTYK
gene id: 9031:DSTYK
uniprot id: Q6XUX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.
messages: Widely expressed with the highest expression in brain and ovary.

9031:CHRM4
gene id: 9031:CHRM4
uniprot id: P17200
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
messages: Cell membrane
messages: Expressed in heart and brain.
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. May couple to multiple functional responses in cell lines.

9031:QKI
gene id: 9031:QKI
uniprot id: A0A8V0XU17
uniprot id: Q9YH18
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the quaking family.
messages: Cytoplasm
messages: Homodimer; does not require RNA to homodimerize.
messages: Major isoform.
messages: Nucleus
messages: RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (By similarity). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (By similarity). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (By similarity). Promotes the formation of circular RNAs (circRNAs): acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation (By similarity). Acts as an important regulator of muscle development (By similarity).

9031:GH
gene id: 9031:GH
uniprot id: P08998
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Growth hormone plays an important role in growth control.
messages: Secreted

9031:GHSR
gene id: 9031:GHSR
uniprot id: Q7ZT14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:RBM24
gene id: 9031:RBM24
uniprot id: Q5ZMA3
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed in differentiated myotomal muscle progenitors in embryos at 3 days of development (at protein level). Expressed in somites in embryos at 3 and 3.5 days of development. Expressed in the mesodermal core of the first and second branchial arches at 3 days of development. Expressed in forelimbs and hindlimbs at 3.5 days of development. Expressed in non-muscle territories including lens and otic vesicle at 3 days of development.
messages: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating MYOG levels. Binds to a huge amount of mRNAs (By similarity). Involved in embryonic heart development and myogenic differentiation of somitic muscle progenitors (PubMed:25217815).
messages: Nucleus
messages: The RRM domain is necessary for mRNA stability and mRNA translation regulation.

9031:NOB1
gene id: 9031:NOB1
uniprot id: F1NRU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9031:BRPF1
gene id: 9031:BRPF1
uniprot id: A0A8V0ZIL8
uniprot id: Q5F3S4
names: Subcellular Location Annotation
messages: Nucleus

9031:MIER1
gene id: 9031:MIER1
uniprot id: Q5ZKT9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor regulating the expression of a number of genes. Probably functions through recruitment of histone deacetylases involved in chromatin silencing (By similarity).

9031:GYS2
gene id: 9031:GYS2
uniprot id: E1BXK3
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9031:MRRFP1
gene id: 9031:MRRFP1
uniprot id: A0A8V1AIE0
uniprot id: E1BQ58
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9031:OPN5L2
gene id: 9031:OPN5L2
uniprot id: B3XZF6
names: Subcellular Location Annotation
messages: Membrane

9031:NMT1
gene id: 9031:NMT1
uniprot id: A0A1L1RKT0
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9031:SF3B1
gene id: 9031:SF3B1
uniprot id: E1C2C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9031:DLGAP3
gene id: 9031:DLGAP3
uniprot id: A0A1D5PFI6
names: Similarity
messages: Belongs to the SAPAP family.

9031:PSMB2
gene id: 9031:PSMB2
uniprot id: R4GLB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9031:SUCLG2
gene id: 9031:SUCLG2
uniprot id: Q5ZL37
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9031:SP4
gene id: 9031:SP4
uniprot id: A0A1D5PLW4
names: Subcellular Location Annotation
messages: Nucleus

9031:PFDN1
gene id: 9031:PFDN1
uniprot id: A0A1D5PB69
uniprot id: F1NDS5
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9031:NR3C1
gene id: 9031:NR3C1
uniprot id: Q38HX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

9031:MMP2
gene id: 9031:MMP2
uniprot id: Q90611
names: Cofactor
names: Domain
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 4 Ca(2+) ions per subunit.
messages: Ligand for integrin alpha-V/beta-3.
messages: Produced by normal skin fibroblasts.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3).
messages: extracellular matrix

9031:TLR2
gene id: 9031:TLR2
uniprot id: C4PC51
uniprot id: Q9DGB6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Toll-like receptor family.
messages: Binds MYD88 (via TIR domain).
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Highly expressed in ovary. Also detected in brain, heart, lung, liver, spleen and kidney, and at low levels in gizzard, muscle, testis and proventriculus.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Membrane
messages: N-glycosylated.
messages: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).

9031:LDHA
gene id: 9031:LDHA
uniprot id: E1BTT8
uniprot id: P00340
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).

9031:CDC42EP3
gene id: 9031:CDC42EP3
uniprot id: E1C7B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9031:RPL39L
gene id: 9031:RPL39L
uniprot id: Q98TF5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL39 family.
messages: Interacts with IMPACT.

9031:USP1
gene id: 9031:USP1
uniprot id: Q5ZJE0
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:IARS2
gene id: 9031:IARS2
uniprot id: Q5ZKA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

9031:CAPN7
gene id: 9031:CAPN7
uniprot id: A0A8V0Z0N6
names: Similarity
messages: Belongs to the peptidase C2 family.

9031:HMG20A
gene id: 9031:HMG20A
uniprot id: Q5ZKF4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in neuronal differentiation.

9031:BRMS1L
gene id: 9031:BRMS1L
uniprot id: Q5ZLL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRMS1 family.
messages: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity.
messages: Nucleus

9031:SLC18A3
gene id: 9031:SLC18A3
uniprot id: Q6R1Z3
names: Subcellular Location Annotation
messages: Membrane

9031:DLG3
gene id: 9031:DLG3
uniprot id: A0A3Q2U4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9031:SEPTIN5
gene id: 9031:SEPTIN5
uniprot id: A0A8V0ZSS5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9031:SBF2
gene id: 9031:SBF2
uniprot id: A0A8V0ZNP8
uniprot id: E1C7M2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9031:AVDL
gene id: 9031:AVDL
uniprot id: E1BTQ4
names: Similarity
messages: Belongs to the avidin/streptavidin family.

9031:NEFM
gene id: 9031:NEFM
uniprot id: P16053
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with other neuronal intermediate filament proteins to form neuronal filamentous networks (By similarity).
messages: Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
messages: There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
messages: axon
messages: cytoskeleton

9031:ELAVL4
gene id: 9031:ELAVL4
uniprot id: A0A8V0ZSM8
uniprot id: A0A8V0ZSN5
uniprot id: Q9PW22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9031:NANOG
gene id: 9031:NANOG
uniprot id: A7Y7W3
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nanog homeobox family.
messages: During embryonic development, expressed preferentially in epiblastic cells and germ cells. In pre-streak embryos, detected in the whole epiblast, but not in the forming hypoblast (stages XI through XIII) (at protein level). As the primitive streak starts to form, disappears from the primitive streak epiblast, but still expressed throughout the area pellucida epiblast (stage XIV -> 3+). At the end of gastrulation (stage 4+), quickly decreases in the epiblast and persists in a crescent anterior to the emerging head process (stages 4+ through 6). At stage 5, strongly expressed in some of the cells in the germinal crescent, probably corresponding primordial germ cells. At stage 7 (neurula stage), undetectable in differentiated cells (at protein level). As the neural plate forms (stages 6-8), expression in the epiblast is restricted to the anterior neural plate. At stage 33, still expressed in germ cells. At stages 42-43, expressed in gonads, as well as in brain, kidney and heart, but at much lower levels than in proliferating embryonic stem cells.
messages: Nucleus
messages: Strongly down-regulated during embryonic stem cell differentiation, induced either by retinoic acid treatment, or by cell adhesion prevention leading to embryoid body formation.
messages: Transcription factor required for the maintenance of pluripotency and self-renewal of embryonic stem cells.

9031:DHRS7B
gene id: 9031:DHRS7B
uniprot id: A0A3Q2UBH5
uniprot id: F1NH35
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:ZHX2
gene id: 9031:ZHX2
uniprot id: A0A1D5PYW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9031:TRNT1
gene id: 9031:TRNT1
uniprot id: A0A1D5P668
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

9031:C4
gene id: 9031:C4
uniprot id: Q076D6
names: Subcellular Location Annotation
messages: Secreted

9031:ADGRA3
gene id: 9031:ADGRA3
uniprot id: A0A8V0Y2M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9031:SLC25A34
gene id: 9031:SLC25A34
uniprot id: A0A1D5NWQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:CPLX1
gene id: 9031:CPLX1
uniprot id: E1C8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9031:PCNA
gene id: 9031:PCNA
uniprot id: Q9DEA3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with DNMT1 (By similarity). Interacts with CHAF1A. Component of the replisome complex (By similarity).
messages: Monoubiquitinated by the UBE2B-RAD18 complex on Lys-164. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the DCX(DTL) complex, leading to enhance PCNA-dependent translesion DNA synthesis (By similarity).
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9031:LYPLA1
gene id: 9031:LYPLA1
uniprot id: A0A1D5P263
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9031:MAFK
gene id: 9031:MAFK
uniprot id: Q90596
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Maf subfamily.
messages: Homodimer or heterodimer.
messages: Nucleus
messages: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.

9031:SLC22A5
gene id: 9031:SLC22A5
uniprot id: Q5W4T3
names: Subcellular Location Annotation
names: Subunit
messages: Basal cell membrane
messages: Interacts with PDZK1.

9031:HMCES
gene id: 9031:HMCES
uniprot id: Q5ZJT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SOS response-associated peptidase family.
messages: Chromosome
messages: Glu-127 is involved in sensing abasic sites in single-stranded DNA (ssDNA). His-202 stabilizes the abasic sites by forming a hydrogen bond with the O4' hydroxyl group.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).

9031:SLC25A24
gene id: 9031:SLC25A24
uniprot id: A0A3Q2TTG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9031:HCRT
gene id: 9031:HCRT
uniprot id: Q8AV17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: Synapse
messages: Vesicle

9031:ST3GAL5
gene id: 9031:ST3GAL5
uniprot id: A0A8V0Z2U6
uniprot id: Q6R3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:CNOT8
gene id: 9031:CNOT8
uniprot id: Q5ZKA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9031:SIDT1
gene id: 9031:SIDT1
uniprot id: A0A3Q3AP82
uniprot id: F1NBM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9031:TK1
gene id: 9031:TK1
uniprot id: P04047
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration.
messages: Cytoplasm
messages: Homotetramer. Tetramerization from dimerization is induced by ATP and increases catalytic efficiency due to a high affinity for thymidine. Tetramerization is inhibited by phosphorylation at Ser-13. Interacts (via the KEN box) with FZR1.
messages: KEN box sequence located in the C-terminal region is required for its mitotic degradation by the APC/C-FZR1 ubiquitin ligase and interaction capability with FZR1.
messages: Phosphorylated on Ser-13 in mitosis. Phosphorylation of Ser-13 by CDK1 during mitosis reduces homotetramerization and catalytic efficiency when DNA replication is complete and intracellular TK1 is still present at a high level.
messages: Polyubiquitinated. Postmitosis, ubiquitination leads to proteasomal degradation. The KEN box sequence located at the C-terminal region targets for degradation by the anaphase promoting complex (APC/C) activated and rate-limited by FZR1.
messages: Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

9031:LOC107052820
gene id: 9031:LOC107052820
uniprot id: A0A1D5P6V7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:RBM48
gene id: 9031:RBM48
uniprot id: Q5F3S8
names: Function
names: Similarity
messages: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: Belongs to the RBM48 family.

9031:MRPS12
gene id: 9031:MRPS12
uniprot id: A0A8V0XW97
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9031:ILK
gene id: 9031:ILK
uniprot id: Q9DF58
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on serine residues.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cell membrane
messages: Interacts with PXN/PAXILLIN (via LD motif 4).
messages: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling.
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9031:NMB
gene id: 9031:NMB
uniprot id: A0MAR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted

9031:GNAQ
gene id: 9031:GNAQ
uniprot id: Q5F3B5
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9031:CDC14B
gene id: 9031:CDC14B
uniprot id: A0A1D5PXT4
uniprot id: D5K9Y4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9031:ADRA1D
gene id: 9031:ADRA1D
uniprot id: A0A1D5PRZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9031:SNX9
gene id: 9031:SNX9
uniprot id: E1BTY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9031:MAP2K3
gene id: 9031:MAP2K3
uniprot id: A0A1D5PD64
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:AVPR1A
gene id: 9031:AVPR1A
uniprot id: A8CWP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

9031:TNIP2
gene id: 9031:TNIP2
uniprot id: A0A1D5NW22
names: Subcellular Location Annotation
messages: Cytoplasm

9031:VTI1B
gene id: 9031:VTI1B
uniprot id: E1BUX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9031:LOC396008
gene id: 9031:LOC396008
uniprot id: P55806
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.
messages: extracellular space

9031:HACD1
gene id: 9031:HACD1
uniprot id: A0A8V0XQ35
uniprot id: F1NL16
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:ZFP36L2
gene id: 9031:ZFP36L2
uniprot id: S5TYV1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9031:HS6ST1
gene id: 9031:HS6ST1
uniprot id: Q76KB2
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate (By similarity). May also play a role in limb development.
messages: Belongs to the sulfotransferase 6 family.
messages: Expressed in the developing wing bud. At stage 31, widely expressed with a lower level in the heart.
messages: Membrane
messages: N-glycosylated.

9031:SERPINB10B
gene id: 9031:SERPINB10B
uniprot id: O73790
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: Chromosome
messages: DNA-binding protein that promotes DNA condensation into transcriptionally inactive heterochromatin in terminally differentiated avian blood cells. Promotes tight packing of nucleosomes into spherical clusters by binding to linker DNA and subsequent oligomerization. Acts as a cysteine protease inhibitor towards CTSL (cathepsin L1) and CTSV (cathepsin L2), but does not inhibit serine proteases.
messages: Detected in all major blood cell types. Highly expressed in granulocytes (at protein level).
messages: Homodimer and homooligomer. Interaction with DNA promotes oligomerization.
messages: Nucleus

9031:HMGN5
gene id: 9031:HMGN5
uniprot id: A3RKL2
uniprot id: P12902
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
messages: Nucleus
messages: There are two HMG-14 proteins in chicken: HMG-14A the major component, and HMG-14B the minor component.

9031:TXNL4A
gene id: 9031:TXNL4A
uniprot id: A0A1D5PKW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9031:CUL5
gene id: 9031:CUL5
uniprot id: A0A8V0XKY0
names: Similarity
messages: Belongs to the cullin family.

9031:LIG4
gene id: 9031:LIG4
uniprot id: Q90YB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4.
messages: Interacts with XRCC4; the LIG4-XRCC4 subcomplex has a 1:2 stoichiometry (By similarity). Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF (By similarity). Additional component of the NHEJ complex includes PAXX (By similarity). Following autophosphorylation, PRKDC dissociates from DNA, leading to formation of the short-range NHEJ complex, composed of LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF (By similarity).
messages: Nucleus

9031:EAF2
gene id: 9031:EAF2
uniprot id: A0A8V0Z6F3
uniprot id: Q5ZHP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF family.
messages: May act as a transcriptional transactivator.
messages: Nucleus speckle

9031:KLC2
gene id: 9031:KLC2
uniprot id: A0A8V0Z790
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9031:SLC5A11
gene id: 9031:SLC5A11
uniprot id: A0A3Q2U0A6
uniprot id: E1C8N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9031:TMEM132E
gene id: 9031:TMEM132E
uniprot id: F1P195
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9031:CANT1
gene id: 9031:CANT1
uniprot id: Q5ZJN6
names: Similarity
messages: Belongs to the apyrase family.

9031:KDSR
gene id: 9031:KDSR
uniprot id: Q5ZKZ6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:CHRNB2
gene id: 9031:CHRNB2
uniprot id: P09484
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.
messages: Cell membrane
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains. The pentamer alpha3-beta-2 interacts with the conotoxin BuIA and the conotoxin MII (By similarity).
messages: Postsynaptic cell membrane

9031:HSF4
gene id: 9031:HSF4
uniprot id: D0VYS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9031:USP16
gene id: 9031:USP16
uniprot id: A0A8V0Y5F1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Homotetramer.
messages: Nucleus
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9031:ST3GAL3
gene id: 9031:ST3GAL3
uniprot id: A0A1D5PQ75
uniprot id: A0A8V0ZQ30
uniprot id: F1P2W7
uniprot id: I6WCL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:TSHR
gene id: 9031:TSHR
uniprot id: Q3V5L9
uniprot id: Q3V5M0
uniprot id: Q3V5M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

9031:INCENP
gene id: 9031:INCENP
uniprot id: P53352
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INCENP family.
messages: Chromosome
messages: Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP and AURKB; in the complex binds directly to AURKB via the IN box, and forms a triple-helix bundle-based subcomplex with BIRC5 and CDCA8 via its N-terminus. The initially reported homodimerization is questioned as the SAH domain is shown to be monomeric. Interacts with CBX5.
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin. Activates AURKB.
messages: Midbody
messages: Nucleus
messages: Originally predicted to contain a coiled coil domain but shown to contain a stable SAH domain instead.
messages: The IN box mediates interaction with AURKB and AURKC.
messages: The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric.
messages: centromere
messages: kinetochore
messages: spindle

9031:WNT9A
gene id: 9031:WNT9A
uniprot id: Q3L251
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:CD14
gene id: 9031:CD14
uniprot id: B0BL87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

9031:ORC2
gene id: 9031:ORC2
uniprot id: Q5ZJL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

9031:LOC100857348
gene id: 9031:LOC100857348
uniprot id: A0A1D5P6V7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:NRTN
gene id: 9031:NRTN
uniprot id: A2PYM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9031:CLRN1
gene id: 9031:CLRN1
uniprot id: E1C4Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9031:INTS12
gene id: 9031:INTS12
uniprot id: A0A8V0XXG2
uniprot id: E1C843
names: Similarity
messages: Belongs to the Integrator subunit 12 family.

9031:ENTPD1
gene id: 9031:ENTPD1
uniprot id: A0A8V0ZGE3
uniprot id: A0A8V0ZNK0
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9031:CCT4
gene id: 9031:CCT4
uniprot id: Q9I8D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9031:SV2C
gene id: 9031:SV2C
uniprot id: F1NCT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9031:CACNB2
gene id: 9031:CACNB2
uniprot id: E1BZF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

9031:SLC24A4
gene id: 9031:SLC24A4
uniprot id: A0A8V0YS99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9031:SNAP23
gene id: 9031:SNAP23
uniprot id: E1BRL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

9031:OPRK1
gene id: 9031:OPRK1
uniprot id: E1C0V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with NHERF1. Interacts with GABARAPL1.
messages: Membrane

9031:TNMD
gene id: 9031:TNMD
uniprot id: Q6YDP0
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9031:SGCB
gene id: 9031:SGCB
uniprot id: Q5ZJR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

9031:GALNT13
gene id: 9031:GALNT13
uniprot id: A0A8V0Y752
uniprot id: A0A8V0YE26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:KCNK13
gene id: 9031:KCNK13
uniprot id: A0A1D5P3M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9031:PHF20L1
gene id: 9031:PHF20L1
uniprot id: A0A1D5P8S4
names: Subcellular Location Annotation
messages: Nucleus

9031:HOXA11
gene id: 9031:HOXA11
uniprot id: P31258
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:NCBP3
gene id: 9031:NCBP3
uniprot id: Q5ZM19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.
messages: Belongs to the NCBP3 family.
messages: Component of an alternative cap-binding complex (CBC) composed of NCBP1/CBP80 and NCBP3.
messages: Cytoplasm
messages: Nucleus

9031:PSMD4
gene id: 9031:PSMD4
uniprot id: Q5ZI14
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9031:NAAA
gene id: 9031:NAAA
uniprot id: F1NCS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid ceramidase family.
messages: Lysosome

9031:HSDL1
gene id: 9031:HSDL1
uniprot id: A0A8V1A1L2
uniprot id: Q5ZJG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: May catalyze the metabolism of steroid hormones and thus play an important role in sex differentiation, the emergence and maintenance of the secondary sexual characters, and the regulation of endocrine.
messages: Mitochondrion

9031:ABL1
gene id: 9031:ABL1
uniprot id: A0A8V1ACF7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9031:INTS9
gene id: 9031:INTS9
uniprot id: Q5ZKK2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus

9031:DDX51
gene id: 9031:DDX51
uniprot id: A0A8V1A5D6
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9031:SOX2
gene id: 9031:SOX2
uniprot id: P48430
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expression is maximal at stages 24-31, then begins to decline. Expression is low by stage 37 and is absent by stage 39. Does not appear to be expressed in adults.
messages: First expressed in the embryonic neural plate shortly before closure and expression continues in the neural tube. From stage 16 onwards, expressed throughout the CNS including the brain, with expression predominant in the undifferentiated cells of the neural epithelium. Also expressed at a low level in the retina and the gut epithelium. Highly expressed in the lens placode at stage 13 and in the lens at stage 17.
messages: It is uncertain whether Met-1 or Met-4 is the initiator.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional activator (PubMed:7628452). Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3' (PubMed:7628452). In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens (PubMed:7628452). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (PubMed:14517545). May function as a switch in neuronal development (PubMed:7748786).

9031:TCEA2
gene id: 9031:TCEA2
uniprot id: A0A1L1RNA8
uniprot id: A0A8V0ZVY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

9031:MSX2
gene id: 9031:MSX2
uniprot id: P28362
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator in bone development. Binds to DNA (By similarity). Morphogenetic role.
messages: Belongs to the Msh homeobox family.
messages: Nucleus

9031:ACE2
gene id: 9031:ACE2
uniprot id: A0A5J6CU64
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9031:RELL1
gene id: 9031:RELL1
uniprot id: Q5F3A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RELT family.
messages: Cell membrane

9031:SFXN2
gene id: 9031:SFXN2
uniprot id: F1NDD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9031:VIP
gene id: 9031:VIP
uniprot id: P48143
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: PHI also causes vasodilation.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

9031:NSMCE1
gene id: 9031:NSMCE1
uniprot id: E1BWX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9031:EFNB2
gene id: 9031:EFNB2
uniprot id: Q9PUJ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:ABLIM3
gene id: 9031:ABLIM3
uniprot id: A0A8V0YF19
names: Subcellular Location Annotation
messages: Cytoplasm

9031:SIRT3
gene id: 9031:SIRT3
uniprot id: A0A1D5NYI2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

9031:NAT10
gene id: 9031:NAT10
uniprot id: Q5ZJN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9031:BEST4
gene id: 9031:BEST4
uniprot id: A0A1D5P6F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

9031:HSD3B1
gene id: 9031:HSD3B1
uniprot id: Q91997
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9031:ARHGEF7
gene id: 9031:ARHGEF7
uniprot id: A0A3Q2TZR1
uniprot id: A0A3Q3API9
names: Subcellular Location Annotation
messages: lamellipodium

9031:SOX8
gene id: 9031:SOX8
uniprot id: P57074
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.
messages: Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
messages: Widely expressed in the embryo.

9031:LOC769866
gene id: 9031:LOC769866
uniprot id: A0A8V0XPF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9031:SRM
gene id: 9031:SRM
uniprot id: A0A1D5NY06
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9031:PHACTR1
gene id: 9031:PHACTR1
uniprot id: A0A8V0Y5V2
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9031:LOC395551
gene id: 9031:LOC395551
uniprot id: A4UIL7
uniprot id: Q90826
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Homodimer.
messages: Monokine with inflammatory and chemokinetic properties.
messages: Secreted

9031:CCND3
gene id: 9031:CCND3
uniprot id: Q5ZKI9
names: Similarity
messages: Belongs to the cyclin family.

9031:PNPLA6
gene id: 9031:PNPLA6
uniprot id: A0A8V0XL35
uniprot id: B0FLU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:ARVCF
gene id: 9031:ARVCF
uniprot id: A0A8V0ZTI6
names: Similarity
messages: Belongs to the beta-catenin family.

9031:CS
gene id: 9031:CS
uniprot id: A0A8V1A0Y3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

9031:PSMA3
gene id: 9031:PSMA3
uniprot id: Q5ZLI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9031:CCNI
gene id: 9031:CCNI
uniprot id: F1P1K0
names: Similarity
messages: Belongs to the cyclin family.

9031:E2F3
gene id: 9031:E2F3
uniprot id: A0A8V0XRX4
uniprot id: F1NR90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9031:SGTB
gene id: 9031:SGTB
uniprot id: Q5ZJ95
names: Similarity
messages: Belongs to the SGT family.

9031:SSU72
gene id: 9031:SSU72
uniprot id: Q5ZJQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Cytoplasm
messages: May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination.
messages: Nucleus

9031:BRIP1
gene id: 9031:BRIP1
uniprot id: Q3YK19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway of DNA repair, after FANCD2 ubiquitination. Probably not involved in the repair of DNA double-strand breaks by homologous recombination.
messages: Nucleus

9031:FAM134C
gene id: 9031:FAM134C
uniprot id: A0A3Q2UKZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:TMEM233
gene id: 9031:TMEM233
uniprot id: A0A8V0ZUT5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9031:INIP
gene id: 9031:INIP
uniprot id: F1NAD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9031:PDK1
gene id: 9031:PDK1
uniprot id: F1NLP2
uniprot id: Q5ZLT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9031:F9
gene id: 9031:F9
uniprot id: Q804X6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by factor XIa, which excises the activation peptide. The propeptide can also be removed by snake venom protease.
messages: Belongs to the peptidase S1 family.
messages: Calcium binds to the gamma-carboxyglutamic acid (Gla) residues in the Gla domain. Calcium can also bind, with stronger affinity, to another site beyond the Gla domain. Under physiological ion concentrations, Ca(2+) is displaced by Mg(2+) from some of the gammaglutamate residues in the N-terminal Gla domain. This leads to a subtle conformation change that may affect the interaction with its binding protein.
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Heterodimer of a light chain and a heavy chain; disulfide-linked.
messages: Secreted
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

9031:ZC3H12B
gene id: 9031:ZC3H12B
uniprot id: A0A1D5PB60
names: Similarity
messages: Belongs to the ZC3H12 family.

9031:MYCN
gene id: 9031:MYCN
uniprot id: E1C3E1
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9031:NRXN1
gene id: 9031:NRXN1
uniprot id: D0PRN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neurexin family.
messages: Brain and arteries (at protein level).
messages: Membrane
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling (By similarity). Plays a role in angiogenesis.

9031:TESC
gene id: 9031:TESC
uniprot id: A0AVX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcineurin regulatory subunit family. CHP subfamily.
messages: Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the bipotential gonad by E4.5 and expressed in both the testis and ovary by E5.5, but with expression higher in the testis. Expressed in the testis cords but also at low levels in the interstitium. In the ovary, expression is principally in the ovarian cortex, but also in the medulla. Also expressed in the embryonic brain, with expression highest in the region between the nasal placode and olfactory bulb. Also expressed in the embryonic heart and tail.
messages: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin (By similarity).
messages: Membrane
messages: Monomer (By similarity). Homodimer (By similarity).
messages: Nucleus
messages: lamellipodium
messages: ruffle membrane

9031:TERF2
gene id: 9031:TERF2
uniprot id: Q9PU53
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (By similarity).
messages: Highly expressed in embryo.
messages: Homodimer. Component of the shelterin complex (telosome) (By similarity). Interacts with TERF2IP/RAP1.
messages: Nucleus
messages: telomere

9031:VPS36
gene id: 9031:VPS36
uniprot id: A0A8V0XGX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

9031:CELF3
gene id: 9031:CELF3
uniprot id: A0A8V1ABK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Nucleus

9031:RPS27L
gene id: 9031:RPS27L
uniprot id: A0A3Q2TV39
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9031:GDAP2
gene id: 9031:GDAP2
uniprot id: A0A8V0ZUK7
names: Similarity
messages: Belongs to the GDAP2 family.

9031:MEIS2
gene id: 9031:MEIS2
uniprot id: F5ANJ3
uniprot id: Q9PTH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9031:LIX1
gene id: 9031:LIX1
uniprot id: Q8UVV7
names: Developmental Stage
names: Similarity
messages: Belongs to the LIX1 family.
messages: Transiently expressed in the nascent hindlimb bud between Hamburger-Hamilton stages 15 and 19. Also found in the basal plate of rhombomeres 3 and 5, in pharyngeal and in foregut mesenchyme and in all facial primordia except for the mandibular arches.

9031:EIF2S2
gene id: 9031:EIF2S2
uniprot id: Q9DEQ6
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9031:TBL1XR1
gene id: 9031:TBL1XR1
uniprot id: Q5ZKZ7
names: Similarity
messages: Belongs to the WD repeat EBI family.

9031:GNB1
gene id: 9031:GNB1
uniprot id: F1NLV4
uniprot id: Q5ZLB5
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9031:ARSH
gene id: 9031:ARSH
uniprot id: Q71BV1
names: Similarity
messages: Belongs to the sulfatase family.

9031:CHD7
gene id: 9031:CHD7
uniprot id: Q06A37
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Expressed in the neural epithelium, otic placodes, optic placodes, branchial arches, and the olfactory placodes,.
messages: Expression is pan-neuronal at stages 8-20. Expressed throughout the rostral neural ectoderm and along the rostrocaudal axis but is absent from the more lateral, non-neuronal ectoderm. Adjacent to the neural tube, detected at the optic and otic placodes. At stage 20, expression is observed in the branchial arches and olfactory placodes in addition to brain and optic and otic placodes.
messages: Nucleus
messages: Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity).

9031:VTG2
gene id: 9031:VTG2
uniprot id: P02845
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Tissue Specificity
messages: After incorporation from serum via a specific receptor, it is cleaved into four fragments, heavy and light chain lipovitellins, phosphovitin and YGP40, and YGP40 is released into the yolk plasma before or during compartmentation of lipovitellin-phosvitin complex into the yolk granule.
messages: By steroids (estrogen).
messages: Cathepsin D is responsible for intraoocytic processing of vitellogenin.
messages: May contain intrachain disulfide bonds.
messages: Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo.
messages: Phosvitin, an egg yolk storage protein, is one of the most highly phosphorylated (10%) proteins in nature.
messages: Precursor of the major egg-yolk proteins that are sources of nutrients during early development of oviparous organisms.
messages: Vitellogenin II is the most abundant of the three vitellogenins (I, II, and III).

9031:ELOVL1
gene id: 9031:ELOVL1
uniprot id: A0A8V0ZRH3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9031:ST3GAL6
gene id: 9031:ST3GAL6
uniprot id: Q70D52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:IGBP1
gene id: 9031:IGBP1
uniprot id: A0A8V0Z1T4
names: Similarity
messages: Belongs to the IGBP1/TAP42 family.

9031:CD320
gene id: 9031:CD320
uniprot id: Q6JBY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SSTR1
gene id: 9031:SSTR1
uniprot id: A9UGZ3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:TM9SF4
gene id: 9031:TM9SF4
uniprot id: F1NVX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9031:TBX19
gene id: 9031:TBX19
uniprot id: P79778
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: First expressed in the early primitive streak. By stage 4, in Hensen node, early prechordal plate and notochord. Also expressed in early development in the neural plate ectoderm immediately anterior to Hensen node. Expression not detected after stage 10-12.
messages: May be involved in the initial formation of the chordamesoderm.
messages: Nucleus

9031:GINS1
gene id: 9031:GINS1
uniprot id: Q5F333
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

9031:RALGPS2
gene id: 9031:RALGPS2
uniprot id: Q5ZJK0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide exchange factor. May be involved in cytoskeletal organization.
messages: The PH domain mediates binding to membranes.

9031:TBPL1
gene id: 9031:TBPL1
uniprot id: Q9YGV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.
messages: Cytoplasm
messages: Nucleus
messages: Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity).
messages: Present in the brain, heart, liver and gizzard.

9031:DNM1L
gene id: 9031:DNM1L
uniprot id: A0A3Q2UHM4
uniprot id: A0A8V0Y8A4
uniprot id: Q5F469
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9031:ADORA2B
gene id: 9031:ADORA2B
uniprot id: O13076
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9031:TMEM80
gene id: 9031:TMEM80
uniprot id: A0A3Q3AHI4
names: Subcellular Location Annotation
messages: Membrane

9031:MLNR
gene id: 9031:MLNR
uniprot id: B2KSC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:RAB3IL1
gene id: 9031:RAB3IL1
uniprot id: E1C3B3
names: Similarity
messages: Belongs to the SEC2 family.

9031:ODF2
gene id: 9031:ODF2
uniprot id: Q5ZKK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODF2 family.
messages: Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail (By similarity).
messages: Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network (By similarity).
messages: centriole
messages: centrosome
messages: cilium
messages: flagellum
messages: spindle pole

9031:TMEM129
gene id: 9031:TMEM129
uniprot id: Q5ZI25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9031:MPP1
gene id: 9031:MPP1
uniprot id: Q5ZJ00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: May play a role in the regulation of neutrophil polarization.
messages: Membrane
messages: stereocilium

9031:RAB11A
gene id: 9031:RAB11A
uniprot id: Q5ZJN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Endosome membrane
messages: Golgi apparatus
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling (By similarity). May also be involved in the regulation of preciliary trafficking and neosynthesized protein export (By similarity).
messages: phagosome
messages: trans-Golgi network

9031:EVA1CL
gene id: 9031:EVA1CL
uniprot id: A0A8V0YS53
names: Similarity
messages: Belongs to the EVA1 family.

9031:RPL19
gene id: 9031:RPL19
uniprot id: Q5ZKK8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

9031:IGF2BP3
gene id: 9031:IGF2BP3
uniprot id: Q5ZLP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All KH domains contribute binding to target mRNA. Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 also contribute. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.
messages: Belongs to the RRM IMP/VICKZ family.
messages: Cytoplasm
messages: Homodimer and multimer.
messages: Nucleus
messages: P-body
messages: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability.
messages: Stress granule

9031:OXSR1
gene id: 9031:OXSR1
uniprot id: A0A3Q2U9U9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9031:ZDHHC20
gene id: 9031:ZDHHC20
uniprot id: A0A8V0XRH9
uniprot id: A0A8V0XRI9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:SLCO4C1
gene id: 9031:SLCO4C1
uniprot id: R4GGA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9031:PRRX1
gene id: 9031:PRRX1
uniprot id: Q05437
uniprot id: Q8UVD3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At stage 10, expressed in the neural tube throughout the mesoderm. By early stage 13, expression becomes restricted to the lateral mesoderm in the trunk region and in the cranial region, to the dermomyotome, to the somatic mseoderm-derived pericardium and to a group of cells located ventral to the dermomyotome. Expression continues at high levels in the dermatome. In later stages, high expression found in the limb bud mesenchyme pharyngeal arches, the maxillary arches and the frontonasal mass and to a lesser extent, in the aorta, cardiac valve mesenchyme, the pericardial wall and the ventral foregut wall.
messages: Belongs to the paired homeobox family.
messages: Expressed predominantly in the mesodermal cells of the limb bud, visceral arches and craniofacial process, and at lower levels, in cranial mesenchyme, upper and lower eyelids, somites and cartilage of vertebra. Also found in the heart, especially the developing semilunar and atrioventricular valves and in the brain, in a distinct region of the ventral part of the hypothalamus as well as in a broader region of the telencephalon.
messages: Interacts with MAF and MAFB.
messages: May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face.
messages: Nucleus

9031:BARX1
gene id: 9031:BARX1
uniprot id: Q9DED6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the BAR homeobox family.
messages: Expressed in smooth muscle cells of the upper digestive organs and their attached arteries and to craniofacial structures.
messages: Interacts with serum response factor (SRF).
messages: Nucleus
messages: Transcription factor which is involved with the serum response factor (SRF) in the smooth muscle cell-specific transcription of the beta-tropomyosin gene in the upper digestive organs and their attached arteries.

9031:PARN
gene id: 9031:PARN
uniprot id: Q5ZJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm

9031:MBLAC2
gene id: 9031:MBLAC2
uniprot id: Q5F336
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18.
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cell membrane
messages: Endoplasmic reticulum membrane

9031:CCT8
gene id: 9031:CCT8
uniprot id: A0A8V0Y814
uniprot id: Q6EE31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.
messages: Cytoplasm
messages: centrosome
messages: cilium basal body

9031:HAGHL
gene id: 9031:HAGHL
uniprot id: Q5ZLY2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Hydrolase acting on ester bonds.

9031:TBCA
gene id: 9031:TBCA
uniprot id: F1NVH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9031:TK2
gene id: 9031:TK2
uniprot id: Q5ZI21
names: Similarity
messages: Belongs to the DCK/DGK family.

9031:ASXL2
gene id: 9031:ASXL2
uniprot id: A0A3Q2UB41
uniprot id: Q5ZM88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may be required for an association with nuclear receptors.
messages: Nucleus
messages: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (By similarity).

9031:PSME3
gene id: 9031:PSME3
uniprot id: Q5F3J5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1 (By similarity).
messages: Belongs to the PA28 family.
messages: Homoheptamer.
messages: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity).

9031:DDX20
gene id: 9031:DDX20
uniprot id: F1P5C0
names: Similarity
messages: Belongs to the DEAD box helicase family.

9031:CYP11A1
gene id: 9031:CYP11A1
uniprot id: O13254
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion inner membrane

9031:VHL
gene id: 9031:VHL
uniprot id: A0A8V0Z8B2
names: Similarity
messages: Belongs to the VHL family.

9031:TAF3
gene id: 9031:TAF3
uniprot id: Q5F489
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF3 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TAF10 via the histone fold. Interacts with TAF13, TBP, SAP130 and GCN5L2. Interacts with TBPL2.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF3 forms the TFIID-A module together with TAF5 and TBP. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process.

9031:MC1R
gene id: 9031:MC1R
uniprot id: Q59I39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9031:PDK4
gene id: 9031:PDK4
uniprot id: F1NYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9031:FOXE1
gene id: 9031:FOXE1
uniprot id: R4GIS6
names: Subcellular Location Annotation
messages: Nucleus

9031:TP73
gene id: 9031:TP73
uniprot id: A0A8V0ZJ40
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Found in a complex with p53/TP53 and CABLES1.
messages: Nucleus
messages: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

9031:CYP2C23a
gene id: 9031:CYP2C23a
uniprot id: P05180
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: By phenobarbital (PubMed:2424910). Significantly increased expression by estrogen. Rapidly up-regulated within 0.5 hour after extrogen exposure with a peak at 1-4 hours. Expression is significantly decreased below control level after 30 hours (PubMed:11572089).
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Expressed in liver.
messages: Microsome membrane

9031:UBAP2L
gene id: 9031:UBAP2L
uniprot id: H9L3J8
names: Subcellular Location Annotation
messages: Cytoplasm

9031:NTRK1
gene id: 9031:NTRK1
uniprot id: Q90699
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9031:LOC396480
gene id: 9031:LOC396480
uniprot id: H9KZL7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:NR5A2
gene id: 9031:NR5A2
uniprot id: A0A1D5PUH1
uniprot id: O42101
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Detected in liver and adrenal gland.
messages: Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism (By similarity). Activates the transcription of CYP2C38 (By similarity).
messages: Nucleus

9031:CDC34
gene id: 9031:CDC34
uniprot id: F1NL19
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:CTH
gene id: 9031:CTH
uniprot id: E1BYF1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9031:MTHFR
gene id: 9031:MTHFR
uniprot id: E1BXL1
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

9031:RPL37A
gene id: 9031:RPL37A
uniprot id: P32046
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9031:MYO1B
gene id: 9031:MYO1B
uniprot id: A0A8V0YG88
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:C2orf40
gene id: 9031:C2orf40
uniprot id: A0A8K1B0E1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9031:AQP10
gene id: 9031:AQP10
uniprot id: A0A8V1A5Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9031:MAML1
gene id: 9031:MAML1
uniprot id: A0A8V0Z600
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9031:LAP3
gene id: 9031:LAP3
uniprot id: Q5ZJU9
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9031:MID1IP1
gene id: 9031:MID1IP1
uniprot id: Q6Q123
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9031:PTP4A1
gene id: 9031:PTP4A1
uniprot id: Q5ZIQ1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9031:LOC107049042
gene id: 9031:LOC107049042
uniprot id: A0A8V1A8A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:TEAD1
gene id: 9031:TEAD1
uniprot id: A0A1D5PMA2
names: Subcellular Location Annotation
messages: Nucleus

9031:AGPAT4
gene id: 9031:AGPAT4
uniprot id: E1BY49
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9031:GJD4
gene id: 9031:GJD4
uniprot id: E1C7P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:RIMBP2
gene id: 9031:RIMBP2
uniprot id: Q8QFX1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RIMBP family.
messages: Brain, cochlea and retina.
messages: Cell membrane
messages: Interacts with RIMS1, RIMS2, CACNA1D and CACNA1B, and potentially with other Ca(2+) channel alpha-1 isoforms.
messages: Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
messages: Synapse
messages: The SH3 domains mediate binding to a proline-rich motif in RIMS1, RIMS2, CACNA1D and CACNA1B.

9031:METTL2B
gene id: 9031:METTL2B
uniprot id: Q5ZHP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. METL family.
messages: Cytoplasm
messages: Monomer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). N(3)-methylcytidine methylation by METTL2 requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite.

9031:TSNARE1
gene id: 9031:TSNARE1
uniprot id: A0A3Q3AGU9
names: Similarity
messages: Belongs to the syntaxin family.

9031:LOC100859722
gene id: 9031:LOC100859722
uniprot id: A0A1L1RYD1
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:ALDH1A1
gene id: 9031:ALDH1A1
uniprot id: P27463
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (By similarity). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
messages: Homotetramer.
messages: axon
messages: cytosol

9031:PSMG1
gene id: 9031:PSMG1
uniprot id: Q5F3H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with psmg2.

9031:LOC417937
gene id: 9031:LOC417937
uniprot id: E1BSS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9031:ATP5F1AW
gene id: 9031:ATP5F1AW
uniprot id: A0A8V0Y6W1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9031:PPP3CA
gene id: 9031:PPP3CA
uniprot id: A0A8V0XL95
uniprot id: A0A8V0XRD8
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9031:CBL
gene id: 9031:CBL
uniprot id: Q98TY6
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9031:MVB12B
gene id: 9031:MVB12B
uniprot id: F1P3Y0
uniprot id: Q5F367
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9031:TMCC3
gene id: 9031:TMCC3
uniprot id: A0A8V0Y7E3
uniprot id: F1NWA6
names: Similarity
messages: Belongs to the TEX28 family.

9031:CBFB
gene id: 9031:CBFB
uniprot id: Q8QGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

9031:CGA
gene id: 9031:CGA
uniprot id: F1NJD3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer of an alpha and a beta chain.
messages: Secreted

9031:EPHA8
gene id: 9031:EPHA8
uniprot id: A0A8V0YYI3
names: Subcellular Location Annotation
messages: Membrane

9031:MGAT4A
gene id: 9031:MGAT4A
uniprot id: Q5F407
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity).
messages: Golgi apparatus membrane
messages: Inhibited by UDP.
messages: N-glycosylated.
messages: Secreted

9031:SLC1A3
gene id: 9031:SLC1A3
uniprot id: A0A3Q2U6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9031:NDFIP2
gene id: 9031:NDFIP2
uniprot id: Q5F3V5
names: Subcellular Location Annotation
messages: Membrane

9031:RNF152
gene id: 9031:RNF152
uniprot id: E1C2W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation.
messages: Lysosome membrane

9031:GALK2
gene id: 9031:GALK2
uniprot id: Q5ZMN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Nucleus

9031:LOC772071
gene id: 9031:LOC772071
uniprot id: A0A1D5P5X7
uniprot id: A0A8V0YM69
uniprot id: A0A8V0YM73
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9031:FAM198A
gene id: 9031:FAM198A
uniprot id: A0A8V0Z338
names: Similarity
messages: Belongs to the GASK family.

9031:LOC421583
gene id: 9031:LOC421583
uniprot id: A0A8V0XQ77
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9031:LSAMP
gene id: 9031:LSAMP
uniprot id: Q98919
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. IgLON family.
messages: Cell membrane
messages: Mediates selective neuronal growth and axon targeting. Probably serves as a recognition molecule for the formation of limbic connections (By similarity).

9031:LOC426385
gene id: 9031:LOC426385
uniprot id: Q5ZJE9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:PADI3
gene id: 9031:PADI3
uniprot id: F1NP39
uniprot id: O57400
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9031:TNFRSF10B
gene id: 9031:TNFRSF10B
uniprot id: Q9IAR7
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

9031:CFC1
gene id: 9031:CFC1
uniprot id: Q9I8Q3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Cell membrane
messages: First detected in the early streak embryo, specifically in the epiblast layer. At the late streak stage, expression is condensed in the rostral half of the primitive streak. At HH stage 4 expression appeared for the first time in the mesendodermal layer of the presumptive prechordal plate rostrally and in the expanding mesoderm laterally. At HH stage 6, labeling in mesendodermal progenitors underlying the future forebrain level of the neuraxis reached its maximum, whereas mesoderm expression, which was restricted to the lateral plate, was accompanied by an underlying endodermal expression at the level of the heart-forming regions. Later gastrulation (HH stage 5-7) was marked by strong expression in the notochord, beneath the future floor plate of the neural tube. Expressed in Hensen node, within its mesenchymal core beneath the epiblast, and at a time when it is morphologically asymmetric.
messages: May play a role in mesoderm and/or neural patterning during gastrulation.
messages: Secreted

9031:RBP2
gene id: 9031:RBP2
uniprot id: F1NZY4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9031:VDAC3
gene id: 9031:VDAC3
uniprot id: A0A8V0YXU7
names: Similarity
messages: Belongs to the eukaryotic mitochondrial porin family.

9031:TRMT6
gene id: 9031:TRMT6
uniprot id: Q5ZJK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

9031:ITM2A
gene id: 9031:ITM2A
uniprot id: Q5F3H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9031:KIT
gene id: 9031:KIT
uniprot id: Q08156
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: High in the brain and testes and also present in the bursa of Fabricus, heart, kidney, lung, spleen thymus and ovary.
messages: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. KIT promotes activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor (By similarity).
messages: Ubiquitinated. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation.

9031:SPIN1L
gene id: 9031:SPIN1L
uniprot id: Q90WG2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SPIN/STSY family.
messages: Expressed in early embryo.
messages: Expressed predominantly in ovarian granulosa and thecal cell.
messages: May play a role in mitosis.
messages: Nucleus

9031:KCNA10
gene id: 9031:KCNA10
uniprot id: Q7T199
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.
messages: Detected in brain, cochlear sensory epithelium, cochlear ganglion, tegumentum vasculosum. Detected at low levels in cochlear lagena.
messages: First detected at very low levels at embryonic day 6. Detected at embryonic day 9 and 14, and 3 days after hatching.
messages: Homotetramer.
messages: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP (By similarity).
messages: Membrane
messages: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

9031:NUS1
gene id: 9031:NUS1
uniprot id: F1N8Y0
names: Similarity
messages: Belongs to the UPP synthase family.

9031:WBSCR22
gene id: 9031:WBSCR22
uniprot id: Q5ZI10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9031:AGO3
gene id: 9031:AGO3
uniprot id: F1P3Z0
uniprot id: Q5ZLG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family. Ago subfamily.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.

9031:CRB2
gene id: 9031:CRB2
uniprot id: A0A8V1AI95
uniprot id: E1BYW1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:RDH14
gene id: 9031:RDH14
uniprot id: F1N970
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:SIX1
gene id: 9031:SIX1
uniprot id: Q3C2H5
names: Subcellular Location Annotation
messages: Nucleus

9031:FFAR2L7
gene id: 9031:FFAR2L7
uniprot id: A0A0C4WTK8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:LGI1
gene id: 9031:LGI1
uniprot id: Q1EGJ8
names: Subcellular Location Annotation
messages: Secreted

9031:STXBP5L
gene id: 9031:STXBP5L
uniprot id: A0A8V1A593
uniprot id: A0A8V1A8A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9031:MTPN
gene id: 9031:MTPN
uniprot id: Q91955
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myotrophin family.
messages: Cytoplasm
messages: Nucleus
messages: Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity).
messages: perinuclear region

9031:ASPHD1
gene id: 9031:ASPHD1
uniprot id: E1BSD3
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9031:CHPT1
gene id: 9031:CHPT1
uniprot id: Q5ZHQ5
uniprot id: R9PXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes.
messages: Golgi apparatus membrane

9031:RPL7L1
gene id: 9031:RPL7L1
uniprot id: Q5ZKA7
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9031:YPEL1
gene id: 9031:YPEL1
uniprot id: A0A3Q2UEU8
names: Similarity
messages: Belongs to the yippee family.

9031:GATA5
gene id: 9031:GATA5
uniprot id: F1NZV5
names: Subcellular Location Annotation
messages: Nucleus

9031:ZDHHC2
gene id: 9031:ZDHHC2
uniprot id: A0A8V0YUB9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:VMA21
gene id: 9031:VMA21
uniprot id: Q5ZLL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase) (By similarity). Interacts with ATP6AP2 (By similarity).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9031:CCN3
gene id: 9031:CCN3
uniprot id: P28686
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CCN family.
messages: Brain and heart, and at a lower level in muscle and intestine, in the embryo. Lung and less so in brain and spleen, in adult chicken.
messages: Cytoplasm
messages: Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro.
messages: MAV1-induced nephroblastomas express a high level of NOV gene whose transcription is normally arrested in adult kidney.
messages: Secreted
messages: gap junction

9031:GDE1
gene id: 9031:GDE1
uniprot id: A0A1D5PNJ4
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:TLX1
gene id: 9031:TLX1
uniprot id: O93366
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Seems to be involved in the development of cranial sensory innervation from peripheral ganglia.

9031:SCGN
gene id: 9031:SCGN
uniprot id: E1BY74
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ATP9B
gene id: 9031:ATP9B
uniprot id: A0A1D5P8E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:LRRC8A
gene id: 9031:LRRC8A
uniprot id: E1BQK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9031:STC2
gene id: 9031:STC2
uniprot id: E1BRJ2
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9031:SMYD5
gene id: 9031:SMYD5
uniprot id: Q5ZIZ2
names: Function
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression.

9031:ZPR1
gene id: 9031:ZPR1
uniprot id: F6T844
names: Similarity
messages: Belongs to the ZPR1 family.

9031:CRAT
gene id: 9031:CRAT
uniprot id: A0A8V1AJL7
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9031:ZYX
gene id: 9031:ZYX
uniprot id: Q04584
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Nucleus
messages: cytoskeleton
messages: focal adhesion

9031:PYGL
gene id: 9031:PYGL
uniprot id: Q7ZZK3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9031:TAF11
gene id: 9031:TAF11
uniprot id: E1C6Y5
names: Similarity
messages: Belongs to the TAF11 family.

9031:EFL1
gene id: 9031:EFL1
uniprot id: Q5F430
names: Subcellular Location Annotation
messages: Nucleus

9031:SLC2A2
gene id: 9031:SLC2A2
uniprot id: Q90592
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: D-glucose and maltose competitively inhibit fructose transport. D-glucose, D-fructose and maltose inhibit deoxyglucose transport.
messages: Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells.

9031:CATH2
gene id: 9031:CATH2
uniprot id: C4PFJ8
uniprot id: Q2IAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cathelicidin family.
messages: Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.
messages: Detected in trachea, lung, proventriculus, duodenum, jejunum, ileum, caeca, colon, caecal tonsil, bursa of Fabricius, kidney, ovary, testis, thymus, liver, spleen, bone marrow, skin, uropygial gland, muscle and brain.
messages: Secreted

9031:RABGGTB
gene id: 9031:RABGGTB
uniprot id: F1P4E5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9031:ADSL
gene id: 9031:ADSL
uniprot id: P21265
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Expressed in liver.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.
messages: Significantly increased expression by estrogen. Rapidly up-regulated within 0.5 hour after extrogen exposure with a peak at 1-4 hours and diminishing thereafter.

9031:CLDN9
gene id: 9031:CLDN9
uniprot id: A0A1D5PQ41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:LUC7L3
gene id: 9031:LUC7L3
uniprot id: A0A1D5P7P5
uniprot id: Q5ZIU4
names: Similarity
messages: Belongs to the Luc7 family.

9031:SLC7A5
gene id: 9031:SLC7A5
uniprot id: Q5ZIJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9031:HSPA2
gene id: 9031:HSPA2
uniprot id: A0A346RQZ3
uniprot id: P08106
uniprot id: Q7SX63
names: Domain
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.

9031:CYP46A1
gene id: 9031:CYP46A1
uniprot id: F1NEB6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:GLYCTK
gene id: 9031:GLYCTK
uniprot id: A0A3Q2U5V7
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9031:AHSA1
gene id: 9031:AHSA1
uniprot id: E1C123
names: Similarity
messages: Belongs to the AHA1 family.

9031:SMCO4
gene id: 9031:SMCO4
uniprot id: R4GG67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMCO4 family.
messages: Membrane

9031:TBCK
gene id: 9031:TBCK
uniprot id: Q5F361
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Cytoplasm
messages: Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization.
messages: Midbody
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: spindle

9031:DENND6A
gene id: 9031:DENND6A
uniprot id: Q5F3L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF) for RAB14.
messages: Recycling endosome

9031:PPEF1
gene id: 9031:PPEF1
uniprot id: E1BTX9
names: Similarity
messages: Belongs to the PPP phosphatase family.

9031:CAPN11
gene id: 9031:CAPN11
uniprot id: P00789
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by micromolar concentrations of calcium and inhibited by calpastatin.
messages: Belongs to the peptidase C2 family.
messages: Binds 3 Ca(2+) ions.
messages: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
messages: Cell membrane
messages: Cytoplasm
messages: Heterodimer of large (catalytic) and a small (regulatory) subunit.
messages: The N-terminus is blocked.
messages: This protein was previously thought to be M-calpain but has since been found to be an intermediate form between the M and Mu types.
messages: Ubiquitously expressed.

9031:SAP18
gene id: 9031:SAP18
uniprot id: Q90ZH5
names: Function
names: Similarity
messages: Belongs to the SAP18 family.
messages: Involved in the tethering of the SIN3 complex to core histone proteins.

9031:CASP2
gene id: 9031:CASP2
uniprot id: Q98943
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit.
messages: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
messages: Only form found in the ovary.

9031:FAR1
gene id: 9031:FAR1
uniprot id: Q5ZM72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis.
messages: Peroxisome membrane

9031:IMP3
gene id: 9031:IMP3
uniprot id: A0A3Q2U8J0
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9031:MRPL50
gene id: 9031:MRPL50
uniprot id: Q5ZLC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

9031:CALHM2
gene id: 9031:CALHM2
uniprot id: E1C257
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9031:CDKN1B
gene id: 9031:CDKN1B
uniprot id: Q8JIV2
names: Similarity
messages: Belongs to the CDI family.

9031:GMPPA
gene id: 9031:GMPPA
uniprot id: A0A8V0Z6G1
uniprot id: F1NYN9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9031:MTMR12
gene id: 9031:MTMR12
uniprot id: F1NQP5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9031:DNAAF4
gene id: 9031:DNAAF4
uniprot id: Q5QIE2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Dynein axonemal particle
messages: neuron projection

9031:CAPZA1
gene id: 9031:CAPZA1
uniprot id: P13127
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
messages: Heterodimer of an alpha and a beta subunit. Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters (By similarity). Component of the WASH complex (By similarity).
messages: Present in all tissues examined.
messages: Was originally thought to have an internal disulfide bond.
messages: Z line

9031:YKT6
gene id: 9031:YKT6
uniprot id: A0A1D5PH43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9031:NUDT19
gene id: 9031:NUDT19
uniprot id: Q5ZL13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).
messages: Monomer.
messages: Peroxisome

9031:TNNI2
gene id: 9031:TNNI2
uniprot id: P68246
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the troponin I family.
messages: Binds to actin and tropomyosin.
messages: The N-terminus is blocked.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9031:PLOD1
gene id: 9031:PLOD1
uniprot id: P24802
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
messages: Homodimer.
messages: Rough endoplasmic reticulum membrane

9031:RCAN3
gene id: 9031:RCAN3
uniprot id: Q5ZJV6
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).

9031:GPR34
gene id: 9031:GPR34
uniprot id: Q6XCE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Orphan receptor.

9031:NUTF2
gene id: 9031:NUTF2
uniprot id: F1NLL4
uniprot id: Q5ZLY4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9031:GPR107
gene id: 9031:GPR107
uniprot id: Q5ZJ99
names: Subcellular Location Annotation
messages: Membrane

9031:TTC39A
gene id: 9031:TTC39A
uniprot id: A0A8V1A0L8
names: Similarity
messages: Belongs to the TTC39 family.

9031:RPS12
gene id: 9031:RPS12
uniprot id: P84175
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS12 family.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Subunit of the 40S ribosomal complex (By similarity).
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Subunit of the 40S ribosomal complex (By similarity).
messages: nucleolus

9031:PTGS2
gene id: 9031:PTGS2
uniprot id: P27607
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: By cytokines and mitogens.
messages: Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
messages: Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(…
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Microsome membrane
messages: PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
messages: The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.

9031:OTUD6A
gene id: 9031:OTUD6A
uniprot id: Q5ZIP6
names: Function
messages: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes.

9031:LOC101751709
gene id: 9031:LOC101751709
uniprot id: R4GJP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:NEUROD1
gene id: 9031:NEUROD1
uniprot id: P79765
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator that mediates transcriptional activation by binding to E box-containing promoter (5'-CANNTG-3') (PubMed:9310321, PubMed:9740021). Acts as a differentiation factor during neurogenesis (PubMed:9310321). Induces photoreceptor cell overproduction in vivo and de novo generation in vitro (PubMed:9740021). May play a role in photoreceptor cell production (PubMed:9740021).
messages: Cytoplasm
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: In the spinal cord it is found in neurons that are migrating or have reached their final position. Expressed in cells located at the outer portion of the developing retinal neuroepithelium, the location where prospective photoreceptors reside.
messages: Nucleus

9031:PRPSAP1
gene id: 9031:PRPSAP1
uniprot id: A0A8V1AKA5
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9031:MAT1A
gene id: 9031:MAT1A
uniprot id: E1C735
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9031:IL17RD
gene id: 9031:IL17RD
uniprot id: Q7T2L7
names: Function
names: Subcellular Location Annotation
messages: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
messages: Membrane

9031:RNF114
gene id: 9031:RNF114
uniprot id: Q5ZM24
uniprot id: Q6J211
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
messages: Nucleus

9031:SPRY2
gene id: 9031:SPRY2
uniprot id: Q9PTL2
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as an antagonist of FGF-induced retinal lens fiber differentiation (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). May play an important role in FGF-mediated patterning of the mid/hindbrain region by acting to modulate the signaling effects of FGF8 (PubMed:10662503).
messages: At the 4- to 5-somite stage (4/5S) found in the embryo in scattered cells across the neural plate in the presumptive mid/ hindbrain region (PubMed:10662503). At 7/8S found in the isthmus and throughout the presumptive r1 territory. Between 10-14S stage found throughout the R1 region and at the isthmic constriction (PubMed:10662503). By 26S the anterior limit of expression extends into the posterior midbrain region and this pattern of expression is maintained at later stages (PubMed:10662503).
messages: Belongs to the sprouty family.
messages: Brain and interlimb region.
messages: By FGF signaling.
messages: Cytoplasm
messages: Membrane
messages: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

9031:FAM65C
gene id: 9031:FAM65C
uniprot id: A0A8V0YQN1
names: Similarity
messages: Belongs to the RIPOR family.

9031:ANKRD1
gene id: 9031:ANKRD1
uniprot id: Q7ZT11
names: Function
names: Subcellular Location Annotation
messages: May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.
messages: Nucleus

9031:ADH1C
gene id: 9031:ADH1C
uniprot id: P23991
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

9031:IL17RA
gene id: 9031:IL17RA
uniprot id: W0GHX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:TMEM65
gene id: 9031:TMEM65
uniprot id: Q5ZKY6
names: Subcellular Location Annotation
messages: Membrane

9031:UBE2U
gene id: 9031:UBE2U
uniprot id: R4GJY8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:C3AR1L
gene id: 9031:C3AR1L
uniprot id: Q5ZIN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9031:IRF5
gene id: 9031:IRF5
uniprot id: Q5ZJM5
names: Subcellular Location Annotation
messages: Nucleus

9031:ESRP2
gene id: 9031:ESRP2
uniprot id: Q5ZLR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus
messages: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity).

9031:CDH11
gene id: 9031:CDH11
uniprot id: O93319
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration.
messages: Cell membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:BID
gene id: 9031:BID
uniprot id: Q8JGM8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.
messages: Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity).
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2 family.
messages: Mitochondrion outer membrane

9031:RARS
gene id: 9031:RARS
uniprot id: Q5ZM11
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.
messages: Monomer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.
messages: The alpha-helical N-terminus (residues 1-72) mediates interaction with AIMP1 and thereby contributes to the assembly of the multisynthetase complex.
messages: cytosol

9031:XPO1
gene id: 9031:XPO1
uniprot id: A0A1D5P8H7
uniprot id: Q5ZIV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9031:IL2
gene id: 9031:IL2
uniprot id: O42288
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9031:GABRA1
gene id: 9031:GABRA1
uniprot id: P19150
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Allosterically activated by benzodiazepines, the neuroanesthetic alphaxalone and pentobarbital (By similarity). Inhibited by the antagonist bicuculline (By similarity).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Brain.
messages: Cell membrane
messages: Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.
messages: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
messages: Postsynaptic cell membrane
messages: The extracellular domain contributes to synaptic contact formation.

9031:DUSP4
gene id: 9031:DUSP4
uniprot id: Q9PW71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus
messages: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

9031:ASZ1
gene id: 9031:ASZ1
uniprot id: A0M8U3
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.

9031:TRAM1L1
gene id: 9031:TRAM1L1
uniprot id: Q8AXQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9031:PRKG1
gene id: 9031:PRKG1
uniprot id: A0A8V0ZJY3
uniprot id: A0A8V0ZS54
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9031:GPX4
gene id: 9031:GPX4
uniprot id: Q8QG67
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9031:AVR2
gene id: 9031:AVR2
uniprot id: P56732
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the avidin/streptavidin family.
messages: Homotetramer.
messages: Secreted

9031:KIF1A
gene id: 9031:KIF1A
uniprot id: A0A8V1A8K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

9031:DRD2
gene id: 9031:DRD2
uniprot id: A9YZQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:RAB5B
gene id: 9031:RAB5B
uniprot id: Q5ZHW4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Early endosome membrane
messages: Protein transport. Probably involved in vesicular traffic.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

9031:ADIPOR1
gene id: 9031:ADIPOR1
uniprot id: A0A3Q2UGK1
uniprot id: Q4PKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9031:PABPC1
gene id: 9031:PABPC1
uniprot id: Q5ZL53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9031:SLA
gene id: 9031:SLA
uniprot id: Q7T3X8
names: Subcellular Location Annotation
messages: Cytoplasm

9031:NOP58
gene id: 9031:NOP58
uniprot id: E1BUS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9031:L3MBTL4
gene id: 9031:L3MBTL4
uniprot id: A0A8V0YUY7
names: Subcellular Location Annotation
messages: Nucleus

9031:GCLM
gene id: 9031:GCLM
uniprot id: Q5ZL03
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

9031:CMPK1
gene id: 9031:CMPK1
uniprot id: Q5ZKE7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9031:NMNAT1
gene id: 9031:NMNAT1
uniprot id: A0A1D5NZW2
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9031:TBC1D24
gene id: 9031:TBC1D24
uniprot id: A0A1D5P4W1
uniprot id: F1NEU9
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse

9031:CL2
gene id: 9031:CL2
uniprot id: Q5GAL6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9031:C2H5ORF22
gene id: 9031:C2H5ORF22
uniprot id: E1C2V6
names: Similarity
messages: Belongs to the UPF0489 family.

9031:PCBD2
gene id: 9031:PCBD2
uniprot id: Q9DG45
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
messages: Highest level found in the kidney, liver, heart and ovarian follicles.
messages: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity).
messages: Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.

9031:KCNC4
gene id: 9031:KCNC4
uniprot id: A0A8V1A2Y8
uniprot id: E1C3U8
names: Subcellular Location Annotation
messages: Membrane

9031:HSBP1L1
gene id: 9031:HSBP1L1
uniprot id: A0A1D5PHZ3
names: Similarity
messages: Belongs to the HSBP1 family.

9031:CNP1
gene id: 9031:CNP1
uniprot id: A9CDT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9031:MEX3B
gene id: 9031:MEX3B
uniprot id: A0A8V0Z344
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:LHX5
gene id: 9031:LHX5
uniprot id: E1BQX0
names: Subcellular Location Annotation
messages: Nucleus

9031:PLP1
gene id: 9031:PLP1
uniprot id: P23289
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

9031:MRPL41
gene id: 9031:MRPL41
uniprot id: A0A3Q2UGE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9031:ORMDL3
gene id: 9031:ORMDL3
uniprot id: R4GJY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9031:EXT2
gene id: 9031:EXT2
uniprot id: A0A8V0ZI75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

9031:FGFR1OP
gene id: 9031:FGFR1OP
uniprot id: F1P288
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: cilium basal body

9031:APOV1
gene id: 9031:APOV1
uniprot id: P02659
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: ApoII mRNA induction by estrogen in kidney at day 11 is at 10% of the level in the liver but estrogen-responsiveness decreases later in development and is low in the adult.
messages: Belongs to the apovitellenin family.
messages: By steroids (estrogen).
messages: Homodimer; disulfide-linked.
messages: Produced by the liver, secreted into the blood and then sequestred by receptor mediated endocytosis into growing oocytes.
messages: Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes.

9031:MTFR1
gene id: 9031:MTFR1
uniprot id: Q9PTD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MTFR1 family.
messages: May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission.
messages: Mitochondrion
messages: Widely expressed in embryonic tissues with higher expression in cartilage and hypertrophic chondrocytes. Specifically expressed in hypertrophic chondrocytes (at protein level).

9031:SLC7A1
gene id: 9031:SLC7A1
uniprot id: C0IN11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9031:PNRC2
gene id: 9031:PNRC2
uniprot id: Q5ZMB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
messages: Nucleus
messages: P-body

9031:IRX2
gene id: 9031:IRX2
uniprot id: Q9PU52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9031:KPNA2
gene id: 9031:KPNA2
uniprot id: A0A1L1RX89
uniprot id: Q5ZMA9
names: Similarity
messages: Belongs to the importin alpha family.

9031:WASF3
gene id: 9031:WASF3
uniprot id: A0A3Q2UPF3
uniprot id: E1C2T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9031:EIF3M
gene id: 9031:EIF3M
uniprot id: Q5ZJ64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

9031:HCCS
gene id: 9031:HCCS
uniprot id: Q5F339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Mitochondrion inner membrane

9031:SNRPN
gene id: 9031:SNRPN
uniprot id: Q9PV94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP SmB/SmN family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (By similarity). Component of the U1 snRNP (By similarity). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (By similarity). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (By similarity). Component of the minor spliceosome, which splices U12-type introns (By similarity). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly (By similarity). Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (By similarity). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts with TDRD3 and SNUPN (By similarity). Interacts with PRMT5; interaction leads to it…
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).
messages: cytosol

9031:RNASEH2B
gene id: 9031:RNASEH2B
uniprot id: Q5ZK59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

9031:STAT4
gene id: 9031:STAT4
uniprot id: A0A1D5PNV3
uniprot id: Q08I97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9031:SEMA6B
gene id: 9031:SEMA6B
uniprot id: A0A3S5ZP31
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:RAB10
gene id: 9031:RAB10
uniprot id: Q5ZIT5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Also plays a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. Finally, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (By similarity).
messages: cilium
messages: perinuclear region
messages: phagosome membrane
messages: trans-Golgi network membrane

9031:TSPAN8
gene id: 9031:TSPAN8
uniprot id: E1C3Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:CTSH
gene id: 9031:CTSH
uniprot id: F5CE71
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:ALX4
gene id: 9031:ALX4
uniprot id: O93582
names: Subcellular Location Annotation
messages: Nucleus

9031:PIGG
gene id: 9031:PIGG
uniprot id: A0A8V0YHF9
uniprot id: A0A8V0YM78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:PRCP
gene id: 9031:PRCP
uniprot id: A0A1D5PVG8
names: Similarity
messages: Belongs to the peptidase S28 family.

9031:SERF2
gene id: 9031:SERF2
uniprot id: A0A3Q2ULA2
names: Similarity
messages: Belongs to the SERF family.

9031:ME3
gene id: 9031:ME3
uniprot id: A0A8V0XPQ6
uniprot id: A0A8V0XYP3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9031:UTS2R
gene id: 9031:UTS2R
uniprot id: E1BYR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

9031:ID1
gene id: 9031:ID1
uniprot id: Q90X15
names: Subcellular Location Annotation
messages: Nucleus

9031:ADI1
gene id: 9031:ADI1
uniprot id: Q5ZL43
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

9031:FAM26E
gene id: 9031:FAM26E
uniprot id: Q5F482
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9031:RBBP4
gene id: 9031:RBBP4
uniprot id: A0A8V0YVH2
uniprot id: Q9W7I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Binds directly to histone H4, probably via helix 1 of the histone fold, a region that is not accessible when histone H4 is in chromatin (PubMed:11112423). Interacts with CHAF1A, HDAC1, HDAC2, HDAC3 and HIRA (PubMed:10347232, PubMed:15527972, PubMed:17065558). May also interact with HAT1 (PubMed:11112423, PubMed:11160883).
messages: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism.
messages: Nucleus
messages: telomere

9031:BABAM1
gene id: 9031:BABAM1
uniprot id: A0A8V1AJF1
names: Subcellular Location Annotation
messages: Nucleus

9031:BAIAP2
gene id: 9031:BAIAP2
uniprot id: A0A1D5P0L1
uniprot id: A0A8V1AKR7
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9031:PRLR
gene id: 9031:PRLR
uniprot id: Q04594
uniprot id: Q6QDA0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9031:LAMTOR3
gene id: 9031:LAMTOR3
uniprot id: Q5ZIP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
messages: Belongs to the LAMTOR3 family.
messages: Late endosome membrane
messages: Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).

9031:TMED7
gene id: 9031:TMED7
uniprot id: Q5ZLF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9031:FZD10
gene id: 9031:FZD10
uniprot id: Q9PWH2
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: By Sonic hedgehog (Shh) in limb bud.
messages: Cell membrane
messages: Expressed in the dorsal ectoderm overlying the developing spinal cord.
messages: Expressed in the region posterior to the Hensen node at stage 6. Detected in the dorsal domain of the neural tube and the CNS of the developing embryo. In the developing limb, expression starts at stage 18 in the posterior-dorsal region of the distal mesenchyme, and gradually expands to the anterior-distal region. Also found in the feather bud and branchial arch.
messages: Interacts with WNT7A.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. Activation by WNT7A induces expression of beta-catenin target genes (PubMed:11142678). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:11142678). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
messages: The FZ domain is involved in binding with Wnt ligands.

9031:PAN2
gene id: 9031:PAN2
uniprot id: Q5F450
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9031:FAM69C
gene id: 9031:FAM69C
uniprot id: F1P454
names: Similarity
messages: Belongs to the DIPK family.

9031:SGTA
gene id: 9031:SGTA
uniprot id: Q5ZHW6
names: Similarity
messages: Belongs to the SGT family.

9031:MTCH2
gene id: 9031:MTCH2
uniprot id: Q9PVL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:HNRNPA3
gene id: 9031:HNRNPA3
uniprot id: A0A1D5PXH1
uniprot id: A0A8V0ZQZ3
names: Subcellular Location Annotation
messages: Nucleus

9031:SLC7A13
gene id: 9031:SLC7A13
uniprot id: A0A1D5PVL1
names: Subcellular Location Annotation
messages: Membrane

9031:ERBB3
gene id: 9031:ERBB3
uniprot id: Q2HZD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9031:WWOX
gene id: 9031:WWOX
uniprot id: Q5F389
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Lysosome
messages: Mitochondrion
messages: Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity).

9031:GLRA2
gene id: 9031:GLRA2
uniprot id: A0A8V0X314
uniprot id: A0A8V0X9E5
uniprot id: A0A8V0XC54
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9031:TRAF6
gene id: 9031:TRAF6
uniprot id: E1C626
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9031:SUPT3H
gene id: 9031:SUPT3H
uniprot id: Q5ZIW0
names: Subcellular Location Annotation
messages: Nucleus

9031:ADNP
gene id: 9031:ADNP
uniprot id: A0A1D5PL01
names: Subcellular Location Annotation
messages: Nucleus

9031:USP3
gene id: 9031:USP3
uniprot id: F1NQJ6
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:BIN2
gene id: 9031:BIN2
uniprot id: Q5ZKL7
names: Subcellular Location Annotation
messages: Cytoplasm

9031:PRKCB
gene id: 9031:PRKCB
uniprot id: A0A1D5PCZ1
uniprot id: A0A1D5PUY5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9031:NPY2R
gene id: 9031:NPY2R
uniprot id: Q9DDN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for neuropeptide Y and peptide YY.

9031:ITGAV
gene id: 9031:ITGAV
uniprot id: P26008
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin alpha chain family.
messages: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V (ITGAV) associates with either beta-1 (ITGB1), beta-3 (ITGB3), beta-5 (ITGB5), beta-6 (ITGB6) or beta-8 (ITGB8) (By similarity). Interacts with RAB25. Interacts with CIB1 (By similarity). Integrins ITGAV:ITGB3 and ITGAV:ITGB5 interact with FBLN5 (via N-terminus) (By similarity). ITGAV:ITGB3 and ITGAV:ITGB5 interact with CCN3 (By similarity). ITGAV:ITGB3 interacts with ADGRA2 (By similarity). ITGAV:ITGB3 interacts with FGF2; it is likely that FGF2 can simultaneously bind ITGAV:ITGB3 and FGF receptors (By similarity). ITGAV:ITGB3 is found in a ternary complex with CX3CR1 and CX3CL1. ITGAV:ITGB3 is found in a ternary complex with NRG1 and ERBB3. ITGAV:ITGB3 is found in a ternary complex with FGF1 and FGFR1. ITGAV:ITGB3 is found in a ternary complex with IGF1 and IGF1R (By similarity). ITGAV:ITGB3 interacts with IGF2 (By similarity). ITGAV:ITGB3 and ITGAV:ITGB6 interact with FBN1 (By similarity). ITGAV:ITGB3 interacts with CD9, CD81 and CD151 (via second extracellular domain) (By similarity). ITGAV:ITGB6 interacts with TGFB1 (By similarity).
messages: Membrane
messages: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). ITGAV:ITGB3 acts as a receptor for CD40LG (By similarity).
messages: focal adhesion

9031:ESYT2
gene id: 9031:ESYT2
uniprot id: A0A1D5P2W2
uniprot id: A0A3Q3AYW8
uniprot id: A0A8V1A5Y4
uniprot id: F1NW17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:EIF2A
gene id: 9031:EIF2A
uniprot id: Q5ZKC1
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9031:YWHAE
gene id: 9031:YWHAE
uniprot id: A0A8V1AHK4
uniprot id: Q5ZMT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.
messages: Nucleus

9031:UBE2R2
gene id: 9031:UBE2R2
uniprot id: R4GIV8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:SPP1
gene id: 9031:SPP1
uniprot id: P23498
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
messages: Belongs to the osteopontin family.
messages: Extensively phosphorylated on serine residues.
messages: Ligand for integrin alpha-V/beta-3.
messages: Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
messages: N-glycosylated.
messages: Secreted

9031:CXCR4
gene id: 9031:CXCR4
uniprot id: A0A3S5ZPQ6
uniprot id: Q9DGI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Membrane

9031:PPP1CB
gene id: 9031:PPP1CB
uniprot id: P62207
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Detected in gizzard (at protein level).
messages: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress (By similarity).
messages: Nucleus
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen (By similarity).
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity.

9031:BRD7
gene id: 9031:BRD7
uniprot id: Q5ZKG2
names: Function
names: Subcellular Location Annotation
messages: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Participates in the Wnt signaling pathway. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Inhibits cell cycle progression from G1 to S phase (By similarity).
messages: Chromosome
messages: Nucleus

9031:DERL3
gene id: 9031:DERL3
uniprot id: F6RIR9
uniprot id: Q5ZHP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9031:POU3F4
gene id: 9031:POU3F4
uniprot id: A0A8V0ZAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9031:LMBR1
gene id: 9031:LMBR1
uniprot id: Q7ZUA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the LIMR family.
messages: Detected ubiquitously at low levels throughout the developing embryo. Present initially in the limb mesoderm as the limb bud emerges from the body wall and up-regulated along the posterior margin of the developing limb bud with progression of the limb outgrowth. Higher levels are detected in limb buds, otic vesicles and pharyngeal arches. Isoform 1 is detected in lung, spleen, heart, breast muscle, cartilage and liver of the adult tissues. Isoform 3 is detected in adult lung, spleen, heart and breast muscle but not detected in cartilage and liver.
messages: Membrane
messages: Putative membrane receptor.

9031:HOXB2
gene id: 9031:HOXB2
uniprot id: R4GLI3
names: Subcellular Location Annotation
messages: Nucleus

9031:RAMP3
gene id: 9031:RAMP3
uniprot id: B9VGZ4
names: Similarity
messages: Belongs to the RAMP family.

9031:DPAGT1
gene id: 9031:DPAGT1
uniprot id: A0A1D5PQ50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:RNF175
gene id: 9031:RNF175
uniprot id: F1ND46
names: Subcellular Location Annotation
messages: Membrane

9031:SYT17
gene id: 9031:SYT17
uniprot id: A0A1D5PSH0
uniprot id: A0A8V0ZFD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9031:ITPA
gene id: 9031:ITPA
uniprot id: F1NLH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9031:DKK3
gene id: 9031:DKK3
uniprot id: A0A8V0ZGB2
uniprot id: Q90839
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
messages: Belongs to the dickkopf family.
messages: Expressed in eye lens.
messages: Interacts with LRP5 and LRP6.
messages: Secreted
messages: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.

9031:GRIK2
gene id: 9031:GRIK2
uniprot id: F1NU20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:GDF5
gene id: 9031:GDF5
uniprot id: Q9W6G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9031:EXTL3
gene id: 9031:EXTL3
uniprot id: F1NGB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

9031:TAF12
gene id: 9031:TAF12
uniprot id: Q5ZKX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9031:HNF4A
gene id: 9031:HNF4A
uniprot id: Q5ILH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:GABRE
gene id: 9031:GABRE
uniprot id: P34904
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in several brain regions, including the ectostriatum, nucleus rotundus and hyperstriatum ventrale.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG4 sub-subfamily.
messages: Cell membrane
messages: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
messages: Postsynaptic cell membrane
messages: This subunit carries the benzodiazepine binding site.

9031:EOMES
gene id: 9031:EOMES
uniprot id: R4GH67
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:RNF170
gene id: 9031:RNF170
uniprot id: A0A8V0YK77
uniprot id: D5M8S4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:PALM
gene id: 9031:PALM
uniprot id: A0A1D5PFN2
uniprot id: A0A1L1RL66
uniprot id: A0A8V1ABU1
names: Similarity
messages: Belongs to the paralemmin family.

9031:PLEKHB2
gene id: 9031:PLEKHB2
uniprot id: Q5F3S2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Involved in retrograde transport of recycling endosomes.
messages: Recycling endosome membrane
messages: The PH domain specifically binds phosphatidylserine, which is enriched in recycling endosome membranes, it doesn't recognize PIPs.

9031:SIRT5
gene id: 9031:SIRT5
uniprot id: E1BRE2
uniprot id: R9PXP3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-101 and Arg-104) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
messages: Nucleus
messages: cytosol

9031:MED13
gene id: 9031:MED13
uniprot id: A0A8V1AN45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:PCOLCE2
gene id: 9031:PCOLCE2
uniprot id: A0A8V0YLY1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:GPR1
gene id: 9031:GPR1
uniprot id: F1NYB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9031:GPR83L
gene id: 9031:GPR83L
uniprot id: F8UV75
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:STK4
gene id: 9031:STK4
uniprot id: Q5ZJK4
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Homodimer; mediated via the coiled-coil region.
messages: Nucleus
messages: Proteolytically cleaved by caspase-3 during apoptosis at Asp-325 resulting in a 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N) (By similarity).
messages: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
messages: The C-terminal non-catalytic region inhibits the kinase activity, the enzyme is activated by caspase-cleavage. Homodimerization and autophosphorylation of Thr-182 is also required for full activation (By similarity).

9031:MEA1
gene id: 9031:MEA1
uniprot id: A0A1D5PZX0
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

9031:MST1R
gene id: 9031:MST1R
uniprot id: Q08757
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:PTMA
gene id: 9031:PTMA
uniprot id: A0A1D5PPP9
names: Similarity
messages: Belongs to the pro/parathymosin family.

9031:VAMP7
gene id: 9031:VAMP7
uniprot id: Q5ZL74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: phagosome membrane
messages: secretory vesicle membrane
messages: synaptosome
messages: trans-Golgi network membrane

9031:FAM150B
gene id: 9031:FAM150B
uniprot id: A0A1D5PAD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9031:FLCN
gene id: 9031:FLCN
uniprot id: E1BQH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9031:AQP2
gene id: 9031:AQP2
uniprot id: A7M7C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9031:CSTF2
gene id: 9031:CSTF2
uniprot id: A0A3Q2UCR0
uniprot id: A0A8V0YX48
uniprot id: Q5ZLS0
names: Subcellular Location Annotation
messages: Nucleus

9031:PI15
gene id: 9031:PI15
uniprot id: Q98ST6
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: First expressed the mesoderm of the emerging dorsal pancreatic bud at stage 17-18. Also expressed in the thyroid anlagen. Expression persists throughout the dorsal pancreatic mesoderm through 6 dpc as the pancreas continues to enlarge. After 6 dpc, the amount of mesoderm in the pancreas declines to a minimal level and little or no expression is seen. The expression in the mesoderm of the thyroid persists at least through 8 dpc in the development of this organ. Weakly expressed within the emerging lung buds and developing gut. Also expressed in developing carniofacial structures. At stage 17, expression is restricted to the cranial paraxial mesoderm. At stage 24, expressed in the corners of the frontonasal mass (globular processes) where the lip will fuse. At stage 26 through 29, becomes focused in the center of the frontonasal mass. At stage 30, further restricted to the future egg tooth. By stage 34, found in the egg tooth and structures derived from the frontonasal mass, such as the premaxillary mesenchyme (PubMed:26385749).
messages: Secreted
messages: Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (PubMed:26385749).
messages: Up-regulated by Noggin/NOG and retinoic acid. May be a direct retinoic acid target.
messages: Was named SugarCrisp after the breakfast cereal.

9031:GPC1
gene id: 9031:GPC1
uniprot id: F1P150
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

9031:METAP2
gene id: 9031:METAP2
uniprot id: Q5ZIL5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9031:CNTN5
gene id: 9031:CNTN5
uniprot id: Q90W79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. Contactin family.
messages: Cell membrane
messages: Contactins mediate cell surface interactions during nervous system development. May contribute to the formation of somatotopic maps of cerebellar afferents during the development of the nervous system.
messages: Expressed by subpopulations of Purkinje cells in the cerebellum. Also expressed by one type of Purkinje cell afferents, the climbing fibers.
messages: Interacts with INgCAM/L1 and the tenascin-R TNP protein. Does not interacts with NrCAM.

9031:GFRA1
gene id: 9031:GFRA1
uniprot id: O13156
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).

9031:MAPRE1
gene id: 9031:MAPRE1
uniprot id: Q5ZLC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: Golgi apparatus
messages: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9031:SLC25A46
gene id: 9031:SLC25A46
uniprot id: Q5ZIG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion outer membrane
messages: Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization. May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane. Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission.

9031:APPL1
gene id: 9031:APPL1
uniprot id: A0A8V1A9G6
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9031:FAM65B
gene id: 9031:FAM65B
uniprot id: Q5F3L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing.
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cytoplasm
messages: Homooligomer; homooligomerization is regulated by RHOC and leads to the formation of concatemers through the association of N- and C-termini. Interacts with NCAM.
messages: cytoskeleton
messages: filopodium
messages: stereocilium
messages: stereocilium membrane

9031:FOXA2
gene id: 9031:FOXA2
uniprot id: Q9PWP8
names: Subcellular Location Annotation
messages: Nucleus

9031:IL1R1
gene id: 9031:IL1R1
uniprot id: Q90874
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9031:ACTR3
gene id: 9031:ACTR3
uniprot id: Q90WD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the actin family. ARP3 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
messages: Detected in fibroblasts.
messages: Nucleus
messages: cytoskeleton

9031:CDH6
gene id: 9031:CDH6
uniprot id: Q90762
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
messages: Cell membrane
messages: First expressed in splanchnic mesoderm of stage 4 embryos. At stage 6, strongly expressed along the neural fold in a region corresponding to the future neural crest. Expression in the neural fold continues during closure of the neural tube but diminishes after neural crest cells have left the neural tube.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:PCMTD1
gene id: 9031:PCMTD1
uniprot id: Q5ZMR3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the active site residue Ser is conserved, appears to lack catalytic activity in vitro.
messages: At its N-terminus, contains L-isoaspartate and S-adenosylmethionine (AdoMet) binding motifs. Also contains an extended SOCS box motif, where the Cul-box is separated from the BC-box by ~90 residues, within its C-terminus.
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Component of the probable ECS(PCMTD1) E3 ubiquitin-protein ligase complex, at least composed of CUL5, ELOB, ELOC, RBX2 and PCMTD1.
messages: Cytoplasm
messages: Membrane
messages: Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity. May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein.

9031:MMP9
gene id: 9031:MMP9
uniprot id: Q9DE15
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:RABEP1
gene id: 9031:RABEP1
uniprot id: A0A8V1AL72
uniprot id: O42351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

9031:RNF7
gene id: 9031:RNF7
uniprot id: Q5ZJA0
names: Similarity
messages: Belongs to the RING-box family.

9031:ERGIC1
gene id: 9031:ERGIC1
uniprot id: A0A8V0Y256
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9031:HTR2A
gene id: 9031:HTR2A
uniprot id: E1BVI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

9031:CERS1
gene id: 9031:CERS1
uniprot id: F1N9S0
names: Subcellular Location Annotation
messages: Membrane

9031:TAF4
gene id: 9031:TAF4
uniprot id: E1BXA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

9031:BKJ
gene id: 9031:BKJ
uniprot id: O13152
names: Similarity
messages: Belongs to the avian keratin family.

9031:HSP90B1
gene id: 9031:HSP90B1
uniprot id: P08110
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Endoplasmic reticulum lumen
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity).
messages: Sarcoplasmic reticulum lumen

9031:PPIE
gene id: 9031:PPIE
uniprot id: A0A8V0Z3A2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

9031:CCKAR
gene id: 9031:CCKAR
uniprot id: A0ZPS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9031:MAP3K8
gene id: 9031:MAP3K8
uniprot id: E1C848
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9031:AR
gene id: 9031:AR
uniprot id: Q2ACE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9031:LOC415664
gene id: 9031:LOC415664
uniprot id: A0A2Z5EM90
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:RAD9A
gene id: 9031:RAD9A
uniprot id: Q76F79
names: Similarity
messages: Belongs to the rad9 family.

9031:KIFC1
gene id: 9031:KIFC1
uniprot id: A1KXL9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:GRK2
gene id: 9031:GRK2
uniprot id: Q5ZJB8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9031:MMP13
gene id: 9031:MMP13
uniprot id: A0A7L8YSP2
uniprot id: O93363
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9031:TAL1
gene id: 9031:TAL1
uniprot id: P24899
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3 (By similarity).
messages: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation.
messages: Nucleus
messages: Phosphorylated on serine residues.

9031:BCL2L14
gene id: 9031:BCL2L14
uniprot id: A0A8V0ZTL6
names: Similarity
messages: Belongs to the Bcl-2 family.

9031:IDI2
gene id: 9031:IDI2
uniprot id: A0A8V0XM86
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9031:SLC11A1
gene id: 9031:SLC11A1
uniprot id: P51027
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NRAMP family.
messages: In response to lymphokine or bacterial products.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
messages: Macrophages; spleen and thymus and at lower level in liver and lung.

9031:HMOX1
gene id: 9031:HMOX1
uniprot id: P14791
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form arises by proteolytic removal of the membrane anchor.
messages: Belongs to the heme oxygenase family.
messages: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:1996964, PubMed:2158889). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity).
messages: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
messages: Endoplasmic reticulum membrane
messages: Homodimer and higher order homooligomer. Oligomerization is crucial for its stability and function in the endoplasmic reticulum.
messages: Inhibited by metalloporphyrins in the following order of decreasing potency: tin mesoporphyrin > tin protoporphyrin > zinc protoporphyrin > manganese protoporphyrin > cobalt protoporphyrin.
messages: The transmembrane domain is necessary for its oligomerization.

9031:ELF1
gene id: 9031:ELF1
uniprot id: Q5ZMG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:DSTN
gene id: 9031:DSTN
uniprot id: P18359
names: Function
names: Similarity
messages: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
messages: Belongs to the actin-binding proteins ADF family.

9031:SMARCB1
gene id: 9031:SMARCB1
uniprot id: Q5ZK40
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) (By similarity). Component of the BAF (SWI/SNF) chromatin remodeling complex. Component of the SWI/SNF-B (PBAF) chromatin remodeling complex. Binds to double-stranded DNA.
messages: Involved in chromatin-remodeling. Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity).
messages: Nucleus
messages: The N-terminal DNA-binding region is structurally similar to winged helix domains.

9031:SLC6A12
gene id: 9031:SLC6A12
uniprot id: E1BQT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:PSAP
gene id: 9031:PSAP
uniprot id: O13035
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Lysosome
messages: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
messages: Saposin-B is a homodimer.
messages: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.
messages: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).
messages: Secreted
messages: The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymatic proteins: the sphingolipids activator proteins (coproteins).
messages: This precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins.

9031:UCHL1
gene id: 9031:UCHL1
uniprot id: A1IMF0
names: Similarity
messages: Belongs to the peptidase C12 family.

9031:RORA
gene id: 9031:RORA
uniprot id: A0A3Q2UCE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:CTTNBP2
gene id: 9031:CTTNBP2
uniprot id: A0M8U5
names: Subcellular Location Annotation
messages: cell cortex
messages: dendritic spine

9031:GRHL3
gene id: 9031:GRHL3
uniprot id: A0A1D5PGS7
uniprot id: A0A3Q3AVX2
names: Subcellular Location Annotation
messages: Nucleus

9031:RARRES1
gene id: 9031:RARRES1
uniprot id: C7G540
uniprot id: Q90YI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protease inhibitor I47 (latexin) family.
messages: Component of the matrix of the eggshell.
messages: Expressed at high levels in the uterine and isthmus regions of the oviduct, and concentrated in the eggshell.
messages: Secreted

9031:IL1RAPL2
gene id: 9031:IL1RAPL2
uniprot id: A0A8V0YEW7
uniprot id: A0A8V0YH07
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9031:TMSB4Y
gene id: 9031:TMSB4Y
uniprot id: A0A3Q2UAP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9031:MMADHC
gene id: 9031:MMADHC
uniprot id: Q5ZKP2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer with MMACHC. Forms a multiprotein complex with MMACHC, MTR and MTRR.
messages: Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Mitochondrion

9031:MCOLN2
gene id: 9031:MCOLN2
uniprot id: A0A8V0ZM53
uniprot id: E1BWI2
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9031:ATP13A2
gene id: 9031:ATP13A2
uniprot id: Q5F3F1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:TOMM5
gene id: 9031:TOMM5
uniprot id: A0A8V0X9V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

9031:AVD
gene id: 9031:AVD
uniprot id: P02701
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the avidin/streptavidin family.
messages: Homotetramer.
messages: N-linked glycan at Asn-41 consists of GlcNAc(beta1-2)Man(alpha1-3)[GlcNAc(beta1-4)][Man(alpha1-?)Man(alpha1-6)] Man(beta1-4)GlcNAc(beta1-4)GlcNAc.
messages: Secreted
messages: Synthesized in hen oviduct and concentrated in egg white (where it represents 0.05% of the total protein).
messages: The biological function of avidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of avidin).

9031:MAFB
gene id: 9031:MAFB
uniprot id: Q90888
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha-A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE).
messages: Belongs to the bZIP family. Maf subfamily.
messages: Expressed in brain, thymus, gut, lung, mesenterium, spleen, kidney, ovary and bursa.
messages: Expressed in the lens placode at stages 5, 8 and 14. Expressed at stage 18 when the invaginating lens placode closes to form the lens vesicle.
messages: Homodimer or heterodimer with other bHLH-Zip transcription factors (By similarity). Binds DNA as a homodimer or heterodimer. Self-associates; the interaction requires the intact MAFB leucine-zipper domain. Interacts with FOS, HOXD12 and PRRX1.
messages: Nucleus

9031:SULT1B1
gene id: 9031:SULT1B1
uniprot id: Q8JG30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3).

9031:NCDN
gene id: 9031:NCDN
uniprot id: Q5ZIG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse
messages: Probably involved in signal transduction, in the nervous system. Required for the spatial learning process. May also be involved in neurite outgrowth (By similarity).
messages: cytosol
messages: dendrite

9031:CRKL
gene id: 9031:CRKL
uniprot id: A0A8V1ACY3
names: Similarity
messages: Belongs to the CRK family.

9031:PCM1
gene id: 9031:PCM1
uniprot id: Q8AV28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PCM1 family.
messages: Cytoplasmic granule
messages: Required for centrosome assembly and function (PubMed:12403812). Essential for the correct localization of several centrosomal proteins including CETN3 and PCNT (By similarity). Required to anchor microtubules to the centrosome (PubMed:12403812). Probably involved in the biogenesis of cilia (By similarity).
messages: Self-associates.
messages: centriolar satellite
messages: centrosome
messages: cilium basal body
messages: cytoskeleton

9031:PAF1
gene id: 9031:PAF1
uniprot id: A0A8V0Y4C2
names: Similarity
messages: Belongs to the PAF1 family.

9031:COPG2
gene id: 9031:COPG2
uniprot id: A0A1L1RZW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9031:FOXJ3
gene id: 9031:FOXJ3
uniprot id: A0A3Q3AWD2
uniprot id: A0A8V0ZDT2
names: Subcellular Location Annotation
messages: Nucleus

9031:CDIN1
gene id: 9031:CDIN1
uniprot id: Q5F476
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May play a role in erythroid cell differentiation.
messages: Nucleus

9031:NTN1
gene id: 9031:NTN1
uniprot id: Q90922
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors.
messages: Secreted

9031:PTPN6
gene id: 9031:PTPN6
uniprot id: Q5F3I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9031:TMEFF2
gene id: 9031:TMEFF2
uniprot id: A0A8V0Y1W5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:RSPO2
gene id: 9031:RSPO2
uniprot id: I0IVW2
names: Similarity
messages: Belongs to the R-spondin family.

9031:MC5R
gene id: 9031:MC5R
uniprot id: O73671
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

9031:CNIH3
gene id: 9031:CNIH3
uniprot id: E1BT86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9031:SLCO1B1
gene id: 9031:SLCO1B1
uniprot id: F1NPJ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:HBBR
gene id: 9031:HBBR
uniprot id: P02127
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The rho chain is the major early embryonic beta-type hemoglobin chain.

9031:KCNA4
gene id: 9031:KCNA4
uniprot id: Q9YGX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

9031:NR5A1
gene id: 9031:NR5A1
uniprot id: O42102
uniprot id: Q9PWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9031:RDH11
gene id: 9031:RDH11
uniprot id: E1BTL3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:FXYD6
gene id: 9031:FXYD6
uniprot id: Q5ZM59
names: Similarity
messages: Belongs to the FXYD family.

9031:SLC2A11
gene id: 9031:SLC2A11
uniprot id: E1C4E5
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:POLR2L
gene id: 9031:POLR2L
uniprot id: E1BSY6
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

9031:RPS19BP1
gene id: 9031:RPS19BP1
uniprot id: Q5ZMG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AROS family.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1. Direct regulator of SIRT1.
messages: nucleolus

9031:MYCL
gene id: 9031:MYCL
uniprot id: F1NXY9
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9031:KCTD7
gene id: 9031:KCTD7
uniprot id: Q5ZJP7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be involved in the control of excitability of cortical neurons.
messages: cytosol

9031:LUM
gene id: 9031:LUM
uniprot id: P51890
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: Contains keratan sulfate.
messages: Cornea and other tissues.
messages: extracellular matrix

9031:DARS
gene id: 9031:DARS
uniprot id: Q5ZJQ5
uniprot id: Q5ZJQ6
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9031:MEOX2
gene id: 9031:MEOX2
uniprot id: Q90YH7
names: Subcellular Location Annotation
messages: Nucleus

9031:DDX42
gene id: 9031:DDX42
uniprot id: Q5F485
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands.
messages: Belongs to the DEAD box helicase family. DDX42 subfamily.
messages: Cytoplasm
messages: Nucleus

9031:SMAD1
gene id: 9031:SMAD1
uniprot id: Q56IA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9031:LOC107057556
gene id: 9031:LOC107057556
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:GCGR
gene id: 9031:GCGR
uniprot id: A6N8N7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:TACR1
gene id: 9031:TACR1
uniprot id: Q9W6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:ATP2C1
gene id: 9031:ATP2C1
uniprot id: A0A8V0Z072
uniprot id: A0A8V0ZDM9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:CSF3
gene id: 9031:CSF3
uniprot id: C0MN01
uniprot id: P13854
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage.
messages: Secreted

9031:SLC25A15
gene id: 9031:SLC25A15
uniprot id: Q5ZIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:SSTR3
gene id: 9031:SSTR3
uniprot id: Q4ZJF2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:CD81
gene id: 9031:CD81
uniprot id: Q5F3G3
names: Subcellular Location Annotation
messages: Membrane

9031:NECAP2
gene id: 9031:NECAP2
uniprot id: Q5ZMR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9031:MAFIP
gene id: 9031:MAFIP
uniprot id: E1C2N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

9031:BF1
gene id: 9031:BF1
uniprot id: A0ZXL5
uniprot id: Q5PY04
names: Similarity
messages: Belongs to the MHC class I family.

9031:SNX11
gene id: 9031:SNX11
uniprot id: H9L0R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9031:TCF7
gene id: 9031:TCF7
uniprot id: A0A3Q2TTV3
uniprot id: A0A8V0Z0F6
uniprot id: Q8JHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9031:DMRTB1
gene id: 9031:DMRTB1
uniprot id: E9LHE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9031:PGK2
gene id: 9031:PGK2
uniprot id: P51903
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.
messages: Cytoplasm
messages: Monomer.

9031:FOXO3
gene id: 9031:FOXO3
uniprot id: F1NNE8
names: Subcellular Location Annotation
messages: Nucleus

9031:COA3
gene id: 9031:COA3
uniprot id: A0A8V0ZV35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

9031:RPEL1
gene id: 9031:RPEL1
uniprot id: A0A8V0YHK1
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

9031:ATPAF2
gene id: 9031:ATPAF2
uniprot id: A0A8V0Z276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9031:STK11
gene id: 9031:STK11
uniprot id: Q0GGW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
messages: Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta).
messages: Cytoplasm
messages: Nucleus
messages: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity).
messages: Ubiquitously expressed in all tissues tested. High levels were observed in duodenum and skeletal muscle, lower levels in liver and pancreas.

9031:ST8SIA2
gene id: 9031:ST8SIA2
uniprot id: Q6ZXD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:RNGTT
gene id: 9031:RNGTT
uniprot id: E1C254
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9031:COX7A2L
gene id: 9031:COX7A2L
uniprot id: A0A8V0Z6B5
uniprot id: A0A8V0ZDK7
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9031:ADORA1
gene id: 9031:ADORA1
uniprot id: P49892
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9031:LOC101749175
gene id: 9031:LOC101749175
uniprot id: A0A8V1AM39
names: Subcellular Location Annotation
messages: Membrane

9031:GGA3
gene id: 9031:GGA3
uniprot id: A0A8V1ALS0
uniprot id: Q5F496
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9031:SQSTM1
gene id: 9031:SQSTM1
uniprot id: A0A1D5PLN4
uniprot id: A0A1D5PXQ2
names: Subcellular Location Annotation
messages: autophagosome

9031:DHFR
gene id: 9031:DHFR
uniprot id: A3RKL3
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9031:GCG
gene id: 9031:GCG
uniprot id: P68259
uniprot id: Q3HWX0
uniprot id: Q3HWX1
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
messages: Potent stimulator of glucose-dependent insulin release. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation.
messages: Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
messages: Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1 and GLP-2. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide (By similarity).
messages: Secreted
messages: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.

9031:BCL6
gene id: 9031:BCL6
uniprot id: Q5ZM39
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation (By similarity).

9031:ST8SIA3
gene id: 9031:ST8SIA3
uniprot id: Q6ZXD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:ODR4
gene id: 9031:ODR4
uniprot id: A0A8V0ZIJ2
uniprot id: Q5ZKH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.
messages: Membrane

9031:DTWD2
gene id: 9031:DTWD2
uniprot id: Q5ZM87
names: Similarity
messages: Belongs to the TDD superfamily. DTWD2 family.

9031:ITGA3
gene id: 9031:ITGA3
uniprot id: Q98TT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9031:RSPH3
gene id: 9031:RSPH3
uniprot id: A0A1L1RT39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flagellar radial spoke RSP3 family.
messages: flagellum axoneme

9031:CHRDL1
gene id: 9031:CHRDL1
uniprot id: Q90ZD5
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Mainly expressed in the ventral retina.
messages: Secreted
messages: Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors.

9031:GJC3
gene id: 9031:GJC3
uniprot id: P18861
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Mostly in heart and stomach.
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:MOCS2
gene id: 9031:MOCS2
uniprot id: A0A140T8H0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).
messages: cytosol

9031:LOC107049127
gene id: 9031:LOC107049127
uniprot id: A0A8V0Z313
uniprot id: A0A8V0Z8T6
names: Similarity
messages: Belongs to the serpin family.

9031:RHAG
gene id: 9031:RHAG
uniprot id: Q7T066
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9031:STEAP2
gene id: 9031:STEAP2
uniprot id: E1BTX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9031:HMGA1
gene id: 9031:HMGA1
uniprot id: Q6W8X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9031:IGFBP1
gene id: 9031:IGFBP1
uniprot id: Q6PN72
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:CHRNA8
gene id: 9031:CHRNA8
uniprot id: Q03481
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:PDPK1
gene id: 9031:PDPK1
uniprot id: Q5F3U4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

9031:MTMR1
gene id: 9031:MTMR1
uniprot id: A0A1D5P2Z0
uniprot id: A0A1D5PA82
uniprot id: A0A8V0YB67
uniprot id: F1NGM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9031:TMC3
gene id: 9031:TMC3
uniprot id: Q5YCC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TMC family.
messages: Expressed in a range of tissues including cerebrum, cerebellum, retina, cochlea, lung, liver and heart. Also expressed in the apical, medial and basal portions of the basillar papilla.
messages: Membrane
messages: Probable ion channel.

9031:MCM6
gene id: 9031:MCM6
uniprot id: Q5ZKR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

9031:MNAT1
gene id: 9031:MNAT1
uniprot id: E1BVP0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9031:HS3ST5
gene id: 9031:HS3ST5
uniprot id: R4GJI3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:UNC5C
gene id: 9031:UNC5C
uniprot id: Q7T2Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Cell surface
messages: Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977).
messages: Restricted to proprioceptive neurons.
messages: axon
messages: dendrite
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: synaptosome

9031:MEIS1
gene id: 9031:MEIS1
uniprot id: A0A3Q2U0L7
uniprot id: B6Z9R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9031:CRYBA4
gene id: 9031:CRYBA4
uniprot id: P49152
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9031:GATA4
gene id: 9031:GATA4
uniprot id: P43691
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: More abundant in heart, with lower levels detected in ovary and small intestine.
messages: Nucleus
messages: Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity).

9031:RSPO1
gene id: 9031:RSPO1
uniprot id: E1BVU3
names: Similarity
messages: Belongs to the R-spondin family.

9031:HK1
gene id: 9031:HK1
uniprot id: Q8AYP8
names: Similarity
messages: Belongs to the hexokinase family.

9031:SBNO1
gene id: 9031:SBNO1
uniprot id: A0A8V1A4D5
uniprot id: Q5F371
names: Similarity
messages: Belongs to the SBNO family.

9031:EML4
gene id: 9031:EML4
uniprot id: A0A1D5NU87
uniprot id: A0A8V0Z1F7
uniprot id: F1NH66
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9031:TNFRSF19
gene id: 9031:TNFRSF19
uniprot id: A1XGV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:URM1
gene id: 9031:URM1
uniprot id: Q5ZJU4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3 homolog.
messages: Cytoplasm

9031:LOC395991
gene id: 9031:LOC395991
uniprot id: O42397
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ATP5H
gene id: 9031:ATP5H
uniprot id: E1C658
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9031:LEF1
gene id: 9031:LEF1
uniprot id: O93345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9031:LOC101747587
gene id: 9031:LOC101747587
uniprot id: P0CG62
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family.
messages: Cytoplasm
messages: For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
messages: Mitochondrion outer membrane
messages: Nucleus
messages: Ubiquitin Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

9031:HSPB8
gene id: 9031:HSPB8
uniprot id: E1C6V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.

9031:SEMA3C
gene id: 9031:SEMA3C
uniprot id: O42236
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.
messages: Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin.
messages: Secreted
messages: Strong binding to neuropilin is mediated by the carboxy third of the protein.

9031:ACTG2
gene id: 9031:ACTG2
uniprot id: P63270
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-74 by SETD3.
messages: Monomethylation at Lys-85 (K85me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.
messages: Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9031:CTLA4
gene id: 9031:CTLA4
uniprot id: Q1XDY5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9031:CCR2
gene id: 9031:CCR2
uniprot id: Q702H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:MIS12
gene id: 9031:MIS12
uniprot id: Q1T769
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
messages: kinetochore

9031:FMOD
gene id: 9031:FMOD
uniprot id: P51887
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds keratan sulfate chains.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

9031:SEC24A
gene id: 9031:SEC24A
uniprot id: E1BSA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9031:CNOT2
gene id: 9031:CNOT2
uniprot id: Q5ZKI3
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9031:PEBP1
gene id: 9031:PEBP1
uniprot id: A0A8V0ZTA5
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9031:SEMA6A
gene id: 9031:SEMA6A
uniprot id: A0A090AQR1
uniprot id: A0A090ATY8
uniprot id: A0A090AVG4
uniprot id: E1C1C2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PIAS2
gene id: 9031:PIAS2
uniprot id: A0A8V0Y3I6
uniprot id: Q5ZIN4
names: Similarity
messages: Belongs to the PIAS family.

9031:SLC17A9
gene id: 9031:SLC17A9
uniprot id: Q5ZMU1
names: Subcellular Location Annotation
messages: Membrane

9031:YTHDF1
gene id: 9031:YTHDF1
uniprot id: Q5F3J9
uniprot id: Q5ZME7
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9031:DPF3
gene id: 9031:DPF3
uniprot id: A0A452J871
uniprot id: P58270
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the requiem/DPF family.
messages: Component of the BAF complex. Interacts with acetylated histones H3 and H4. Component of neuron-specific chromatin remodeling complex (nBAF complex), a subfamily of ATP-dependent SWI/SNF chromatin remodeling complexes (By similarity).
messages: Expressed in the heart and somites.
messages: Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and plays a role in neural development.
messages: Nucleus
messages: The PHD-type zinc fingers mediate the binding to acetylated histones.

9031:SLC30A7
gene id: 9031:SLC30A7
uniprot id: Q5MNV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cytoplasmic vesicle
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Mitochondrion
messages: Sarcoplasmic reticulum
messages: Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:15525635, PubMed:15994300, PubMed:16636052). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (PubMed:15525635, PubMed:15994300, PubMed:16636052).
messages: trans-Golgi network

9031:SZRD1
gene id: 9031:SZRD1
uniprot id: Q5ZK25
names: Similarity
messages: Belongs to the SZRD1 family.

9031:DDC
gene id: 9031:DDC
uniprot id: E1BV90
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9031:ZRANB2
gene id: 9031:ZRANB2
uniprot id: Q5ZLX5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: May regulate alternative splicing by interfering with constitutive 5'-splice site selection.
messages: Nucleus
messages: The RanBP2-type zinc fingers mediate binding to RNA.

9031:HOXC9
gene id: 9031:HOXC9
uniprot id: A0A1D5PQW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:EIF3I
gene id: 9031:EIF3I
uniprot id: E1C6T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

9031:KRT24
gene id: 9031:KRT24
uniprot id: O93256
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Expressed in the digestive tract throughout development in the epithelia of proventriculus and glandular structures. In 13 day embryo, strongly expressed in esophagus with moderate expression in proventriculus and lung. Weak expression in gizzard, small intestine, lung and dorsal skin. In embryos over 13 days old, observed in ectodermal, endodermal epithelium and also in neural and mesodermal tissues (i.e. notochord), floorplate in the neural tube, somatic mesoderm, splanchnic mesoderm and dermatome. In more developed embryos, expression was localized in the anterior lobe of the pituitary gland, notochord and hypothalamus of the diencephalon (derived from the floor plate of the neural tube). Also localized in the mesonephric mesoderm and lateral plate mesoderm.
messages: Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD (By similarity).
messages: Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity).
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
messages: This keratin differs from all other IF proteins in lacking the C-terminal tail domain.

9031:RPSAP58
gene id: 9031:RPSAP58
uniprot id: P50890
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9031:BROX
gene id: 9031:BROX
uniprot id: E1BY06
names: Similarity
messages: Belongs to the BROX family.

9031:CCDC167
gene id: 9031:CCDC167
uniprot id: F1NAT1
names: Subcellular Location Annotation
messages: Membrane

9031:TLR4
gene id: 9031:TLR4
uniprot id: C4PCF3
uniprot id: Q7ZTG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9031:PTGFR
gene id: 9031:PTGFR
uniprot id: Q1PA18
uniprot id: Q3HS34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:NADSYN1
gene id: 9031:NADSYN1
uniprot id: Q5ZMA6
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source.
messages: Homohexamer.
messages: In the C-terminal section; belongs to the NAD synthetase family.

9031:FUT4
gene id: 9031:FUT4
uniprot id: Q98952
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9031:SLC5A7
gene id: 9031:SLC5A7
uniprot id: F1P4Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9031:MYOM2
gene id: 9031:MYOM2
uniprot id: Q02173
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Can be detected by day 10-13 in ovo, the content is gradually increased throughout the ovo development and reached its peak after hatching.
messages: Expressed in pectoralis and cardiac muscle.
messages: Is a structural constituent of myofibrillar M-band in striated muscle.

9031:FST
gene id: 9031:FST
uniprot id: Q90844
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds directly to activin and functions as an activin antagonist. Inhibits activin A signaling in the iris and regulates somatostatin phenotype in ciliary ganglion neurons. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
messages: Ciliary ganglion neurons. Levels are higher in the iris than the choroid.
messages: Levels increase in the iris from embryonic day 9 (9 dpc) to 16 dpc in contrast to the choroid where it remains low relative to iris. During early hindbrain development strongly expressed in rhombomeres R2, R4, R5 and R6 but not in R3. Expression in R3 is seen at later stages and is dependent on neighboring interactions.
messages: Monomer.
messages: Secreted

9031:Pou5f3
gene id: 9031:Pou5f3
uniprot id: A7Y7W2
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus
messages: Required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Transcriptional activator that binds the DNA consensus sequence 5'-ATGCAAAT-3'.
messages: Strongly down-regulated during embryonic stem cell differentiation induced either by retinoic acid treatment, or by cell adhesion prevention leading to embryoid body formation.
messages: Widely expressed during embryonic development (at protein level). In pre-primitive streak stage embryos, expressed in the epiblast and in a salt-and-pepper fashion in the forming hypoblast (stages XI and XIII) (at protein level). As the primitive streak starts to form, strongly expressed in the epiblast of the streak itself (stage XIV) and in the mesoderm emerging from it, whereas expression in the lower layer tends to decrease (stages 2 through 4+). Expression in the area opaca is lost by stage 3+. At later stages, continues to be expressed in the mesoderm, but not detected in the endoderm (stages 5 through 8). At stage 5, expressed in all cells of the germinal crescent. At stage 8 and subsequently, strongly expressed in the neural plate and neural tube with particularly strong expression in the anterior hindbrain/posterior midbrain. At stage 9 and subsequently, still expressed in neural tissue and in primordial germ cells (at protein level). At stage 33, still expressed in germ cells. At stages 42-43, expressed in male and female gonads, as well as in spleen and brain, but at much lower levels than in proliferating embryonic stem cells.

9031:TMSB4X
gene id: 9031:TMSB4X
uniprot id: Q6WEB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9031:LOC769852
gene id: 9031:LOC769852
uniprot id: P84229
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

9031:PKP1
gene id: 9031:PKP1
uniprot id: A0A8V1A511
names: Similarity
messages: Belongs to the beta-catenin family.

9031:TDRD3
gene id: 9031:TDRD3
uniprot id: Q5ZMS6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of mRNA stress granules.
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.
messages: The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 'Arg-17' (H3R17me2a) and histones H4 'Arg-3', 2 tags for epigenetic transcriptional activation.

9031:FAM96A
gene id: 9031:FAM96A
uniprot id: Q5ZJP2
names: Similarity
messages: Belongs to the MIP18 family.

9031:ADAM33
gene id: 9031:ADAM33
uniprot id: A3EYJ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SYP
gene id: 9031:SYP
uniprot id: Q90661
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9031:PTPA
gene id: 9031:PTPA
uniprot id: Q5ZM56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9031:CCND1
gene id: 9031:CCND1
uniprot id: P55169
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex (By similarity). The cyclin subunit imparts substrate specificity to the complex (By similarity).
messages: Nucleus
messages: Phosphorylation at Thr-283 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex.
messages: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
messages: Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation. The DCX(AMBRA1) complex represents the major regulator of CCND1 stability during the G1/S transition.

9031:BMP10
gene id: 9031:BMP10
uniprot id: F6S3W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

9031:HIGD1C
gene id: 9031:HIGD1C
uniprot id: Q5ZJI8
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9031:TBK1
gene id: 9031:TBK1
uniprot id: E1C581
names: Subcellular Location Annotation
messages: Cytoplasm

9031:PROX1
gene id: 9031:PROX1
uniprot id: Q91018
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Prospero homeodomain family.
messages: Expressed most actively in the developing lens and midgut and at lower levels in the developing brain, heart, muscle and retina.
messages: First detected at stage 14 in the early lens placode. At later stages of development, it was observed throughout the lens, but it appeared more abundant around the bow region of the equator than in the anterior epithelium or the fibers. In the retina, expression was detected mainly in the inner nuclear layer during later stages of histogenesis.
messages: Nucleus
messages: The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
messages: Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes.

9031:GLP1R
gene id: 9031:GLP1R
uniprot id: B4ZY91
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:CLN8
gene id: 9031:CLN8
uniprot id: A0A1D5NZY8
names: Subcellular Location Annotation
messages: Membrane

9031:ATVR1
gene id: 9031:ATVR1
uniprot id: A0A8V0Y6D3
uniprot id: Q90ZK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity).

9031:OPRM1
gene id: 9031:OPRM1
uniprot id: F1NW54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

9031:DIO3
gene id: 9031:DIO3
uniprot id: O42412
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iodothyronine deiodinase family.
messages: Cell membrane
messages: Endosome membrane
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine).

9031:C10orf2
gene id: 9031:C10orf2
uniprot id: Q5ZIW1
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homohexamer (via C-terminus) which assembled in a ring-like structure. Homoheptamer which assembled in a ring-like structure. Oligomerization is Mg(2+), nucleotide and DNA-independent, however, Mg(2+) and nucleotide stabilize the homohexameric form.
messages: Mitochondrial helicase involved in mtDNA replication and repair. Might have a role in mtDNA repair. Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB. Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate. Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand. In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities.
messages: N-terminus enhances protein stability and hexamer formation, which is important for DNA binding, and is required for DNA helicase activity and, ultimately, for mtDNA replisome processivity.
messages: The N-terminus contains a putative primase-like domain; however the absence of the zinc binding domain and other motifs important for catalysis suggests that TWNK lacks primase activity.
messages: mitochondrion nucleoid

9031:ADRB3
gene id: 9031:ADRB3
uniprot id: A0A4P9IV16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:TMEM258
gene id: 9031:TMEM258
uniprot id: Q76LT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9031:S100A10
gene id: 9031:S100A10
uniprot id: P27003
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
messages: Belongs to the S-100 family.
messages: Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.
messages: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.

9031:METTL6
gene id: 9031:METTL6
uniprot id: A0A1D5PBA2
uniprot id: A0A3Q2U5F1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9031:TFAP2A
gene id: 9031:TFAP2A
uniprot id: A0A8V0XYI6
uniprot id: A0A8V0Y715
uniprot id: O13111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9031:EBF1
gene id: 9031:EBF1
uniprot id: F1N9Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9031:XKR8
gene id: 9031:XKR8
uniprot id: Q49M60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9031:ITPR2
gene id: 9031:ITPR2
uniprot id: A0A1D5P2S9
uniprot id: F1P1X4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9031:BRE
gene id: 9031:BRE
uniprot id: Q5ZML0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1, BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: Nucleus

9031:USP44
gene id: 9031:USP44
uniprot id: F1P4C5
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:SLC6A15
gene id: 9031:SLC6A15
uniprot id: E1BS25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

9031:ACOX1
gene id: 9031:ACOX1
uniprot id: A0A8V1AQ25
uniprot id: Q5ZM10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9031:DIP2A
gene id: 9031:DIP2A
uniprot id: A0A8V0YAH0
uniprot id: A0A8V0YF37
names: Similarity
messages: Belongs to the DIP2 family.

9031:TIMM23B
gene id: 9031:TIMM23B
uniprot id: E1BR29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9031:STX16
gene id: 9031:STX16
uniprot id: A0A8V0YRD7
uniprot id: Q5ZK87
names: Similarity
messages: Belongs to the syntaxin family.

9031:GTF2E2
gene id: 9031:GTF2E2
uniprot id: Q5ZIE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9031:MAL2
gene id: 9031:MAL2
uniprot id: A0A1D5PRH9
uniprot id: Q5F3S0
names: Subcellular Location Annotation
messages: Membrane

9031:CD74
gene id: 9031:CD74
uniprot id: Q6J613
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:RPL24
gene id: 9031:RPL24
uniprot id: A0A8V0XRE7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9031:PLA2G7
gene id: 9031:PLA2G7
uniprot id: Q90678
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
messages: Plasma.
messages: extracellular space

9031:NME5
gene id: 9031:NME5
uniprot id: A0A8V0YTD8
names: Similarity
messages: Belongs to the NDK family.

9031:HMGN4
gene id: 9031:HMGN4
uniprot id: P02314
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
messages: Nucleus

9031:ST8SIA4
gene id: 9031:ST8SIA4
uniprot id: O42399
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:ADCY6
gene id: 9031:ADCY6
uniprot id: A0A1D5P0J0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9031:BMT2
gene id: 9031:BMT2
uniprot id: Q5ZJ87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9031:POLH
gene id: 9031:POLH
uniprot id: Q5ZIW9
names: Subcellular Location Annotation
messages: Nucleus

9031:PDLIM4
gene id: 9031:PDLIM4
uniprot id: Q9PW72
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Early endosome membrane
messages: Interacts (via LIM domain) with PTPN13 (By similarity). Interacts (via PDZ domain) with ACTN1 (PubMed:14729062).
messages: Nucleus
messages: Recycling endosome membrane
messages: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity).
messages: cytoskeleton
messages: dendritic spine
messages: lamellipodium
messages: perinuclear region
messages: synaptosome

9031:RGS2
gene id: 9031:RGS2
uniprot id: Q7ZZS4
uniprot id: Q7ZZS5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: nucleolus

9031:ART7B
gene id: 9031:ART7B
uniprot id: A9NJ59
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9031:C7
gene id: 9031:C7
uniprot id: F1DQG4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:PPP1R21
gene id: 9031:PPP1R21
uniprot id: Q5ZL12
names: Function
names: Subcellular Location Annotation
messages: Early endosome
messages: Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway.

9031:ZDHHC6
gene id: 9031:ZDHHC6
uniprot id: A0A8V0ZI56
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:HCN1
gene id: 9031:HCN1
uniprot id: F1N9K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9031:PHTF1
gene id: 9031:PHTF1
uniprot id: E1BZ77
names: Subcellular Location Annotation
messages: Membrane

9031:AKIRIN2
gene id: 9031:AKIRIN2
uniprot id: E1C249
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9031:PABIR3
gene id: 9031:PABIR3
uniprot id: Q5ZLN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint.
messages: Belongs to the FAM122 family.
messages: Cytoplasm
messages: Nucleus

9031:RXFP2
gene id: 9031:RXFP2
uniprot id: A0A1D5P7S6
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:PPP3CB
gene id: 9031:PPP3CB
uniprot id: Q5ZIM8
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9031:CEPT1
gene id: 9031:CEPT1
uniprot id: F1NT05
uniprot id: Q5ZKD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane

9031:BOK
gene id: 9031:BOK
uniprot id: Q9I8I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: May play a role in apoptosis.
messages: Membrane

9031:TAS2R7
gene id: 9031:TAS2R7
uniprot id: Q2AB81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9031:OGT
gene id: 9031:OGT
uniprot id: A0A8V0YYY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9031:CAMK2G
gene id: 9031:CAMK2G
uniprot id: A0A8V0ZB39
uniprot id: A0A8V0ZI83
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9031:CREB1
gene id: 9031:CREB1
uniprot id: Q7SX83
names: Subcellular Location Annotation
messages: Nucleus

9031:ITGA9
gene id: 9031:ITGA9
uniprot id: Q5ZM22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9031:GAPDH
gene id: 9031:GAPDH
uniprot id: P00356
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
messages: Homotetramer.
messages: Nucleus
messages: S-nitrosylation of Cys-150 leads to translocation to the nucleus.
messages: cytoskeleton
messages: cytosol

9031:FDXR
gene id: 9031:FDXR
uniprot id: A0A8V1AEK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

9031:LOC771085
gene id: 9031:LOC771085
uniprot id: A0A3S5ZPJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9031:H2AFZ
gene id: 9031:H2AFZ
uniprot id: Q5ZMD6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity).
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site.
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).

9031:DKC1
gene id: 9031:DKC1
uniprot id: Q5ZJH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pseudouridine synthase TruB family.
messages: Cajal body
messages: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance.
messages: Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate.
messages: nucleolus

9031:AAR2
gene id: 9031:AAR2
uniprot id: Q5ZJ10
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9031:CCT2
gene id: 9031:CCT2
uniprot id: Q5F424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9031:CHRNA9
gene id: 9031:CHRNA9
uniprot id: Q9PTS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.
messages: Cell membrane
messages: Expressed in hair cells of the cochlea (at protein level). Expressed in hair cells of the cochlea.
messages: Ionotropic receptor that may play a role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane.
messages: Postsynaptic cell membrane

9031:SLC26A5
gene id: 9031:SLC26A5
uniprot id: A0FKN5
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Electrogenic antiporter that exchanges sulfate or oxalate for chloride ion in a strictly coupled manner with a 1:1 stoichiometry (PubMed:17442754, PubMed:24710176, PubMed:22399806). Adopts a dynamic conformation, which alternates between the exposure of the central binding site to the extra- and intracellular solutions leading to an inward-to-outward conformational transition during the transport cycle (PubMed:24710176).
messages: Homodimer (PubMed:26635354). Interacts (via STAS domain) with CALM; this interaction is calcium-dependent (PubMed:33667636).
messages: Sulfate/chloride antiport activity is inhibited by salicylate; this inhibition is reversible.
messages: The anion-binding site in STAS domain is lacking (PubMed:26635354). The STAS domain mediates dimerization, with both STAS domains latched onto each other in a domain-swapped manner. The N-terminus domain is involved in dimerization such that each N-terminus domain embraces both STAS domains (By similarity). The transmembrane domain consists of 14 transmembrane segments organized in a 7(+)7 inverted repeat architecture that can be divided into two main helix bundles, the ''core'' domain and the ''gate'' domain (By similarity). The transmembrane regions are domain-swapped with the STAS domain containing N- and C-terminal cytoplasmic domains (By similarity). The STAS domain mediates CALM binding CALM (PubMed:33667636).
messages: The anion-binding site that controls electromotility and associated charge movement in mammalian corresponds to the central binding site of the anion translocation pathway in non-mammalian.

9031:COPS7A
gene id: 9031:COPS7A
uniprot id: Q5ZJA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9031:IFRD1
gene id: 9031:IFRD1
uniprot id: Q90W08
names: Similarity
messages: Belongs to the IFRD family.

9031:MRPS11
gene id: 9031:MRPS11
uniprot id: Q5ZL20
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9031:USP48
gene id: 9031:USP48
uniprot id: Q5ZM45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Nucleus
messages: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

9031:MRE11
gene id: 9031:MRE11
uniprot id: Q9IAM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11 and NBN. Interacts with DCLRE1C/Artemis (By similarity).
messages: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).
messages: Nucleus

9031:CRYBA2
gene id: 9031:CRYBA2
uniprot id: P55164
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9031:FTL
gene id: 9031:FTL
uniprot id: Q8AYG9
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9031:CENPP
gene id: 9031:CENPP
uniprot id: Q1T7B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-P/CTF19 family.
messages: Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: Component of the CENPA-HI complex, at least composed of CENPH, CENPI, CENPK, CENPL, CENPM, CENPO and CENPP.
messages: Nucleus
messages: centromere

9031:CCND2
gene id: 9031:CCND2
uniprot id: P49706
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
messages: Nucleus
messages: Nucleus membrane
messages: Phosphorylation at Thr-282 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex.
messages: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
messages: Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-282 phosphorylation. The DCX(AMBRA1) complex represents the major regulator of CCND2 stability during the G1/S transition.

9031:RABEPK
gene id: 9031:RABEPK
uniprot id: Q5ZJ37
names: Function
messages: Rab9 effector required for endosome to trans-Golgi network (TGN) transport.

9031:PTPRJ
gene id: 9031:PTPRJ
uniprot id: Q9W6V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
messages: Cell junction
messages: Cell membrane
messages: Found on the apical surfaces of retinal Mueller cells, renal tubule cells and intestinal brush border cells.
messages: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of several substrates (By similarity). Plays a role in cell adhesion, migration, proliferation and differentiation (By similarity). May influence the potential of nonsensory supporting cells to either proliferate or differentiate into hair cells (PubMed:10366616).
messages: ruffle membrane

9031:TRIP12
gene id: 9031:TRIP12
uniprot id: A0A8V0ZS27
uniprot id: A0A8V0ZV74
uniprot id: A0A8V0ZZM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9031:LOC418658
gene id: 9031:LOC418658
uniprot id: A0A8V0XEI4
uniprot id: E1BYN0
names: Similarity
messages: Belongs to the sulfatase family.

9031:TOP1MT
gene id: 9031:TOP1MT
uniprot id: A0A3Q2UPP2
uniprot id: Q6T722
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9031:CDK18
gene id: 9031:CDK18
uniprot id: A0A8V1AC40
uniprot id: E1C3N0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:TIMM10
gene id: 9031:TIMM10
uniprot id: E1BXY8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9031:AGPAT2
gene id: 9031:AGPAT2
uniprot id: A0A8V1AKE3
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9031:TMOD2
gene id: 9031:TMOD2
uniprot id: A0A1D5PW62
names: Subcellular Location Annotation
messages: cytoskeleton

9031:RPL17
gene id: 9031:RPL17
uniprot id: A0A1D5PR40
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9031:JARID2
gene id: 9031:JARID2
uniprot id: Q5F363
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the PRC2 complex.
messages: Belongs to the JARID2 family.
messages: Nucleus
messages: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (By similarity). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity (By similarity).
messages: The ARID domain is required to target the PRC2 complex to its target genes.

9031:PPM1A
gene id: 9031:PPM1A
uniprot id: A0A8V0YY86
uniprot id: E1BVM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9031:ANKRD13A
gene id: 9031:ANKRD13A
uniprot id: A0A8V0ZT30
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9031:SPIN1
gene id: 9031:SPIN1
uniprot id: Q90WG1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SPIN/STSY family.
messages: Expressed in early embryo.
messages: Expressed in several tissues including testis.
messages: May play a role in mitosis.
messages: Nucleus

9031:PPP2CA
gene id: 9031:PPP2CA
uniprot id: Q5ZM47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9031:CXCL13L3
gene id: 9031:CXCL13L3
uniprot id: G4U4M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9031:NAP1L4
gene id: 9031:NAP1L4
uniprot id: A0A8V1A3D3
uniprot id: Q5ZI86
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9031:SLC6A2
gene id: 9031:SLC6A2
uniprot id: A0A1D5P472
uniprot id: Q9DGN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:TNFSF13B
gene id: 9031:TNFSF13B
uniprot id: Q8JHJ4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9031:DRAXIN
gene id: 9031:DRAXIN
uniprot id: B6ZI38
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the draxin family.
messages: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord and cortical explants in vitro. Binds directly to the neurites and growth cones.
messages: Expressed transiently during development of the brain and spinal cord, especially in the roof plate and the dorsal lip of the dermomyotome. Also present at the dorsolateral basement membrane of the spinal cord (at protein level).
messages: Secreted

9031:HCK
gene id: 9031:HCK
uniprot id: A0A8V0YUN5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9031:SLC2A13
gene id: 9031:SLC2A13
uniprot id: A0A8V0XY55
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:LOC770890
gene id: 9031:LOC770890
uniprot id: A0A1L1RQ52
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9031:P3H1
gene id: 9031:P3H1
uniprot id: Q6JHU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the leprecan family.
messages: Binds unfolded collagen in a complex with CYPB and CRTAP.
messages: Endoplasmic reticulum
messages: Expressed in embryonic dermis, tendon, cartilage, liver and kidney. Expression in the kidney is restricted to the calyx. In the liver, expression is restricted to the interlobular septum.
messages: Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types IV and V. May be involved in the secretoty pathway of cells. Has growth suppressive activity in fibroblasts.

9031:OSBPL10
gene id: 9031:OSBPL10
uniprot id: A0A8V0X532
names: Similarity
messages: Belongs to the OSBP family.

9031:P2RX1
gene id: 9031:P2RX1
uniprot id: Q8AWC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9031:RGMA
gene id: 9031:RGMA
uniprot id: Q8JG54
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum.
messages: Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Expressed in the periventricular layer surrounding the tectal ventricle (9 dpc). Forms a spatial gradient with increasing concentration from the anterior to posterior pole of the embryonic optic tectum.

9031:ANKRD13C
gene id: 9031:ANKRD13C
uniprot id: A0A8V0ZXI8
names: Subcellular Location Annotation
messages: Membrane

9031:TMEM132B
gene id: 9031:TMEM132B
uniprot id: F1N8B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9031:DECR2
gene id: 9031:DECR2
uniprot id: F1NG68
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

9031:CAND2
gene id: 9031:CAND2
uniprot id: E1BVC2
names: Similarity
messages: Belongs to the CAND family.

9031:RAD51
gene id: 9031:RAD51
uniprot id: P37383
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Expressed at high levels in lymphoid and reproductive organs.
messages: Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9031:NEU3
gene id: 9031:NEU3
uniprot id: I6LL52
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9031:NPR2
gene id: 9031:NPR2
uniprot id: R4GI22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9031:EMC3
gene id: 9031:EMC3
uniprot id: E1BQV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9031:LOC107055197
gene id: 9031:LOC107055197
uniprot id: E1C5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9031:NKAIN2
gene id: 9031:NKAIN2
uniprot id: A0A8V0XR87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9031:MLLT3
gene id: 9031:MLLT3
uniprot id: A0A1D5PVW7
uniprot id: F1NQ29
names: Subcellular Location Annotation
messages: Nucleus

9031:RPL22
gene id: 9031:RPL22
uniprot id: Q98TF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9031:SLC15A2
gene id: 9031:SLC15A2
uniprot id: U5TSZ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9031:TRAPPC3
gene id: 9031:TRAPPC3
uniprot id: Q5ZI57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer. Part of the multisubunit TRAPP (transport protein particle) complex (By similarity).
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9031:SYT2
gene id: 9031:SYT2
uniprot id: A0A8V1AD51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9031:USP46
gene id: 9031:USP46
uniprot id: A0A1D5PXU2
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:NDUFAF1
gene id: 9031:NDUFAF1
uniprot id: E1BZH1
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9031:RPL35
gene id: 9031:RPL35
uniprot id: Q98TF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9031:BFSP2
gene id: 9031:BFSP2
uniprot id: Q90809
uniprot id: Q90976
names: Similarity
messages: Belongs to the intermediate filament family.

9031:LPAR4
gene id: 9031:LPAR4
uniprot id: E1BWJ9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:EIF3D
gene id: 9031:EIF3D
uniprot id: F1NCE1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Cytoplasm
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9031:CRYBB1
gene id: 9031:CRYBB1
uniprot id: P07530
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9031:CZH18ORF25
gene id: 9031:CZH18ORF25
uniprot id: A0A1D5NXP4
uniprot id: A0A3Q2U1Q8
uniprot id: A0A8V0YG14
names: Subcellular Location Annotation
messages: Nucleus

9031:DNAJC27
gene id: 9031:DNAJC27
uniprot id: Q6IMM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: GTPase possibly involved in regulation of the MEK/ERK pathway.
messages: Nucleus

9031:DMRT1
gene id: 9031:DMRT1
uniprot id: Q0H8S8
names: Similarity
messages: Belongs to the DMRT family.

9031:ADAMTS6
gene id: 9031:ADAMTS6
uniprot id: E1C0H0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:PLAU
gene id: 9031:PLAU
uniprot id: P15120
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Secreted
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9031:CHDSD
gene id: 9031:CHDSD
uniprot id: A0A8V1ABE9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DSD1 family.
messages: Catalyzes the conversion of D-serine, an allosteric activator of the N-methyl-D-aspartate (NMDA) receptor for L-glutamate, to pyruvate and ammonia.
messages: Cytoplasm
messages: Expressed in kidney, specifically in the proximal tubule epithelial cells (at protein level) (PubMed:17977854, PubMed:24529545, PubMed:21676877). Expressed in the liver, specifically in hepatocytes (at protein level) (PubMed:17977854, PubMed:24529545). Low expression levels in cerebellum, brain stem, midbrain and cerebrum (at protein level) (PubMed:17977854, PubMed:24529545). In the cerebellum, expressed in Bergmann glial cells and astrocytes (at protein level) (PubMed:24529545). In the cerebrum, expressed in astrocytes (at protein level) (PubMed:24529545).
messages: Inhibited by hydroxylamine and aminooxyacetate.
messages: May form homo- or hetero- dimers.
messages: dendrite

9031:THOC7
gene id: 9031:THOC7
uniprot id: F1N915
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

9031:KCNJ1
gene id: 9031:KCNJ1
uniprot id: A0A8V0ZV50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9031:TNFSF10
gene id: 9031:TNFSF10
uniprot id: A0A8V0Z0M2
uniprot id: Q5ZK93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

9031:EXOC1
gene id: 9031:EXOC1
uniprot id: A0A8V0YJX7
uniprot id: E1BS87
names: Similarity
messages: Belongs to the SEC3 family.

9031:DPP4
gene id: 9031:DPP4
uniprot id: A0A1D5PJA5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane raft
messages: invadopodium membrane
messages: lamellipodium membrane

9031:CENPS
gene id: 9031:CENPS
uniprot id: E1BSW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (By similarity).
messages: Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners. MHF heterodimers can assemble to form tetrameric structures (PubMed:22304917). MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex (PubMed:22304917). Forms a discrete complex with FANCM and CENPX, called FANCM-MHF; this interaction, probably mediated by direct binding between CENPS and FANCM, leads to synergistic activation of double-stranded DNA binding and strongly stimulates FANCM-mediated DNA remodeling. Recruited by FANCM to the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha (TOP3A), RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. The super complex between FA and BLM is called BRAFT. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).
messages: Nucleus
messages: centromere
messages: kinetochore

9031:IPO7
gene id: 9031:IPO7
uniprot id: F1NBA8
names: Subcellular Location Annotation
messages: Cytoplasm

9031:EXT1
gene id: 9031:EXT1
uniprot id: A0A8V0Y8L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

9031:EIF2B5
gene id: 9031:EIF2B5
uniprot id: A0A8V0ZAC0
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

9031:BTAF1
gene id: 9031:BTAF1
uniprot id: A0A1D5P1T4
names: Subcellular Location Annotation
messages: Nucleus

9031:SCPEP1
gene id: 9031:SCPEP1
uniprot id: A0A8V1APA8
uniprot id: Q5F3W4
names: Similarity
messages: Belongs to the peptidase S10 family.

9031:ATP12A
gene id: 9031:ATP12A
uniprot id: Q5ZIK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

9031:MDH1
gene id: 9031:MDH1
uniprot id: Q5ZME2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).
messages: Homodimer.
messages: cytosol

9031:PRRX2
gene id: 9031:PRRX2
uniprot id: R4GIL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9031:PPP1RL
gene id: 9031:PPP1RL
uniprot id: O13155
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9031:MAP3K7
gene id: 9031:MAP3K7
uniprot id: A0A8V0XCV5
uniprot id: A0A8V0XFP5
uniprot id: A0A8V0XIG1
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9031:PRKCI
gene id: 9031:PRKCI
uniprot id: Q5F3H2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

9031:HTR2B
gene id: 9031:HTR2B
uniprot id: F1NU82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9031:CYP21A1
gene id: 9031:CYP21A1
uniprot id: A5HUM5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:CACNG1
gene id: 9031:CACNG1
uniprot id: F1NC88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

9031:RRAGC
gene id: 9031:RRAGC
uniprot id: A0A1D5PLJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9031:BPNT1
gene id: 9031:BPNT1
uniprot id: Q5ZMR5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9031:ATP5C1
gene id: 9031:ATP5C1
uniprot id: A0A1D5P0U8
uniprot id: A0A1L1RYK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9031:CHAF1A
gene id: 9031:CHAF1A
uniprot id: Q5R1T0
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHAF1A family.
messages: Cells lacking CHAF1A show delayed S-phase progression with retarded DNA synthesis and defects in a rapid nucleosome formation of newly replicated DNA.
messages: Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
messages: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains.
messages: Nucleus
messages: Subunit of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. Interacts with CHAF1B, PCNA and RBBP4 (PubMed:17065558).

9031:KDM4A
gene id: 9031:KDM4A
uniprot id: E1C6D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9031:FOXA1
gene id: 9031:FOXA1
uniprot id: A0A1D5PCB1
names: Subcellular Location Annotation
messages: Nucleus

9031:ARC
gene id: 9031:ARC
uniprot id: Q8AWC3
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ARC/ARG3.1 family.
messages: By synaptic activity. Transcript level significantly increased in auditory cortex as well as two higher-associative brain regions by auditory imprinting stimulus in newborn chicks.
messages: Early endosome membrane
messages: Expressed at various levels throughout the brain.
messages: Extracellular vesicle membrane
messages: Homooligomer; homooligomerizes into virion-like capsids.
messages: Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material.
messages: Palmitoylation anchors the protein into the membrane by allowing direct insertion into the hydrophobic core of the lipid bilayer.
messages: Postsynaptic cell membrane
messages: Postsynaptic density
messages: Synapse
messages: The protein is evolutionarily related to retrotransposon Gag proteins: it contains large N- and C-terminal domains that form a bi-lobar architecture similar to the capsid domain of human immunodeficiency virus (HIV) gag protein. It contains structural elements found within viral Gag polyproteins originated from the Ty3/gypsy retrotransposon family and retains the ability to form virion-like capsid structures that can mediate mRNA transfer between cells. Tetrapod and fly Arc protein-coding genes originated independently from distinct lineages of Ty3/gypsy retrotransposons.
messages: cell cortex
messages: cytoskeleton
messages: dendrite
messages: dendritic spine

9031:ADH4
gene id: 9031:ADH4
uniprot id: Q5ZK81
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9031:TFRC
gene id: 9031:TFRC
uniprot id: Q90997
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
messages: Homodimer; disulfide-linked. Binds one transferrin molecule per subunit (By similarity).
messages: Melanosome
messages: N- and O-glycosylated, phosphorylated and palmitoylated.
messages: Stearoylated (By similarity). Stearoylation does not affect iron uptake (By similarity).

9031:HP1BP3
gene id: 9031:HP1BP3
uniprot id: Q5ZM33
names: Domain
names: Function
names: Subcellular Location Annotation
messages: A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
messages: Chromosome
messages: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity.
messages: Nucleus

9031:ARID1B
gene id: 9031:ARID1B
uniprot id: A0A8V0XN27
names: Subcellular Location Annotation
messages: Nucleus

9031:HPGDS
gene id: 9031:HPGDS
uniprot id: O73888
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the GST superfamily. Sigma family.
messages: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide.
messages: Cytoplasm
messages: Glutathione is required for the prostaglandin D synthase activity.
messages: Highly expressed in liver, kidney, small intestine and colon, moderately in pancreas, bone marrow, lung and ovary, and expressed at low levels in spleen, thymus, heart and brain. Not detected in oviduct or skin (at protein level) (PubMed:9657971). Expressed in liver (PubMed:11572089).
messages: Significantly increased expression by estrogen. Up-regulated after 1 hour of exposure to estrogen. Expression persists through 72 hours.

9031:GSTZ1
gene id: 9031:GSTZ1
uniprot id: A0A1D5PN41
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9031:LOC768614
gene id: 9031:LOC768614
uniprot id: Q9PWI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:IL1RL1
gene id: 9031:IL1RL1
uniprot id: Q9DEE4
uniprot id: Q9DEE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

9031:TFIP11
gene id: 9031:TFIP11
uniprot id: Q5ZII9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.
messages: Nucleus

9031:CYSLTR1
gene id: 9031:CYSLTR1
uniprot id: A0A8V0ZAZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:UBLCP1
gene id: 9031:UBLCP1
uniprot id: Q5ZJJ8
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome where it dephosphorylates 19S component PSMC2 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome.
messages: Nucleus
messages: The Ubiquitin-like domain mediates interaction with proteasomes.

9031:MDK
gene id: 9031:MDK
uniprot id: P24052
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pleiotrophin family.
messages: By retinoic acid.
messages: Cell surface
messages: Essentially expressed during embryogenesis.
messages: Has mitogenic activity, and neurite extension activity for PC12 cells.
messages: basement membrane

9031:PHB2
gene id: 9031:PHB2
uniprot id: Q5ZMN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Cytoplasm
messages: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan.
messages: In the nucleus, serves as transcriptional co-regulator.
messages: Mitochondrion inner membrane
messages: Nucleus
messages: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.
messages: The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2), assembled into a membrane-associated ring-shaped supercomplex of approximately 1 mDa.

9031:CHD1
gene id: 9031:CHD1
uniprot id: O42142
names: Subcellular Location Annotation
messages: Nucleus

9031:PUS3
gene id: 9031:PUS3
uniprot id: F1P3X5
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9031:RORB
gene id: 9031:RORB
uniprot id: Q98934
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:PMP22
gene id: 9031:PMP22
uniprot id: A0A1D5PDJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

9031:CKAP2
gene id: 9031:CKAP2
uniprot id: Q5ZJF0
names: Similarity
messages: Belongs to the CKAP2 family.

9031:PIAS1
gene id: 9031:PIAS1
uniprot id: A0A1D5P1W4
uniprot id: Q5QGZ1
names: Similarity
messages: Belongs to the PIAS family.

9031:TMEM255A
gene id: 9031:TMEM255A
uniprot id: E1BZD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9031:ST6GALNAC5
gene id: 9031:ST6GALNAC5
uniprot id: F6VMN5
uniprot id: Q6ZXY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:GTF2H5
gene id: 9031:GTF2H5
uniprot id: Q5ZKH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Cytoplasm
messages: Nucleus

9031:WNT8A
gene id: 9031:WNT8A
uniprot id: P51030
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Cells that form rhombomere 4. Hensen node and the neural plate immediately anterior to it.
messages: Expressed during embryogenesis.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Is likely to signal over only few cell diameters. May be involved in the regulation of axis formation and in the rhombomere specification.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
messages: Proteolytic processing by tiki1 and tiki2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of wnt8c.
messages: extracellular matrix

9031:CTSV
gene id: 9031:CTSV
uniprot id: F1NYJ1
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:ACTR10
gene id: 9031:ACTR10
uniprot id: Q5ZID3
names: Similarity
messages: Belongs to the actin family.

9031:DCK2
gene id: 9031:DCK2
uniprot id: Q5ZJM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DCK/DGK family.
messages: Expressed at high levels in adult intestine, spleen, thymus and testis with lower levels in skeletal muscle and eye. In the embryo, expressed at higher levels until day 10 with lower levels in later stages.
messages: Homodimer.
messages: Nucleus
messages: Phosphorylates the deoxyribonucleosides deoxyadenosine, deoxycytidine and deoxyguanosine (PubMed:27906638). Shows highest activity against deoxyguanosine followed by deoxycytidine and then deoxyadenosine (PubMed:27906638). Shows only very minor activity against deoxyuridine and deoxythymidine (PubMed:27906638).

9031:CHPF2
gene id: 9031:CHPF2
uniprot id: A0A1L1RW56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9031:GJA4
gene id: 9031:GJA4
uniprot id: F1NJ17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:PFKFB4
gene id: 9031:PFKFB4
uniprot id: A0A8V1A7E3
uniprot id: A0A8V1AHI4
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9031:TMEM192
gene id: 9031:TMEM192
uniprot id: A0A3Q2UAD1
uniprot id: A0A8V0XZV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9031:TMEM161B
gene id: 9031:TMEM161B
uniprot id: A0A8V0XHM0
uniprot id: A0A8V0XRU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9031:MBD4
gene id: 9031:MBD4
uniprot id: Q9I9F1
names: Subcellular Location Annotation
messages: Nucleus

9031:CDADC1
gene id: 9031:CDADC1
uniprot id: A0A1D5NZE1
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9031:CCNT2
gene id: 9031:CCNT2
uniprot id: A0A8V0Z9Z4
uniprot id: A0A8V0ZBG8
names: Similarity
messages: Belongs to the cyclin family.

9031:LOC769223
gene id: 9031:LOC769223
uniprot id: A0A1D5PMF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9031:SURF6
gene id: 9031:SURF6
uniprot id: Q5ZHN7
names: Similarity
messages: Belongs to the SURF6 family.

9031:CHRM2
gene id: 9031:CHRM2
uniprot id: P30372
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
messages: Cell membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
messages: This receptor has a high affinity for pirenzepine.

9031:STRAP
gene id: 9031:STRAP
uniprot id: Q5ZL33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat STRAP family.
messages: Cytoplasm
messages: Nucleus
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex (By similarity).

9031:RPS15
gene id: 9031:RPS15
uniprot id: P62846
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Component of the small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9031:SEMA4D
gene id: 9031:SEMA4D
uniprot id: Q90665
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the semaphorin family.
messages: Cell membrane
messages: Cell surface receptor for PLXNB1 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity).
messages: Homodimer (By similarity). Interacts with PLXNB1 (By similarity).

9031:HINT1
gene id: 9031:HINT1
uniprot id: A0A3Q2UBJ7
names: Similarity
messages: Belongs to the HINT family.

9031:INSR
gene id: 9031:INSR
uniprot id: A0A8V1AFM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9031:FOXP1
gene id: 9031:FOXP1
uniprot id: Q58NQ4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: The leucine-zipper is required for dimerization and transcriptional repression.
messages: Transcriptional repressor.

9031:DDA1
gene id: 9031:DDA1
uniprot id: Q5ZK14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DDA1 family.
messages: Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1.
messages: Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.

9031:KCNJ6
gene id: 9031:KCNJ6
uniprot id: A0A3Q2UNZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9031:NDUFA10
gene id: 9031:NDUFA10
uniprot id: Q5ZIQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

9031:GRIA1
gene id: 9031:GRIA1
uniprot id: A0A1D5PIW7
uniprot id: Q90855
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:SRRM1
gene id: 9031:SRRM1
uniprot id: Q5ZMJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Involved in pre-mRNA splicing and processing events.
messages: Nucleus

9031:LEPR
gene id: 9031:LEPR
uniprot id: Q9I8V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9031:MED22
gene id: 9031:MED22
uniprot id: Q800L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 22 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

9031:YIPF7
gene id: 9031:YIPF7
uniprot id: E1C864
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9031:SDHA
gene id: 9031:SDHA
uniprot id: Q9YHT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9031:TEKT5
gene id: 9031:TEKT5
uniprot id: E1C109
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

9031:DIMT1
gene id: 9031:DIMT1
uniprot id: E1C0U9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9031:FUS
gene id: 9031:FUS
uniprot id: Q6J4Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9031:ADD3
gene id: 9031:ADD3
uniprot id: F1NEA1
uniprot id: Q8AVB3
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9031:LMNA
gene id: 9031:LMNA
uniprot id: P13648
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
messages: Nucleus

9031:KERA
gene id: 9031:KERA
uniprot id: O42235
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds keratan sulfate chains.
messages: Plays an important role in generating and maintaining a transparent matrix within the corneal stroma.
messages: extracellular matrix

9031:RABGAP1L
gene id: 9031:RABGAP1L
uniprot id: Q5ZJ17
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Early endosome
messages: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).
messages: Golgi apparatus
messages: Interacts with ANK2.
messages: The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.

9031:MITF
gene id: 9031:MITF
uniprot id: B6E281
uniprot id: O73871
uniprot id: Q9IAU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9031:ART7C
gene id: 9031:ART7C
uniprot id: A9NJ60
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9031:LOC100859906
gene id: 9031:LOC100859906
uniprot id: A0A8V0Z3F5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9031:ELMO2
gene id: 9031:ELMO2
uniprot id: A0A3Q2UB91
uniprot id: A0A8V0YUQ4
uniprot id: E1C122
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9031:NIM1K
gene id: 9031:NIM1K
uniprot id: E1C6B4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:MYL4
gene id: 9031:MYL4
uniprot id: P09540
names: Miscellaneous
names: Subunit
messages: Light chain 23 is expressed in chicken embryonic skeletal, cardiac, smooth muscles and in brain continuously from embryo to adult.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.

9031:CRIM1
gene id: 9031:CRIM1
uniprot id: Q8AWW5
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed at embryonic stage 20 in the notchcord and weakly in the foor plate and persist until stage 29. Expressed in the motor neuron pool at stage 23. At stage 26 and 29 highly expressed in the ventrolateral neural tube and also in the roof plate.
messages: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.
messages: Membrane

9031:CPEB3
gene id: 9031:CPEB3
uniprot id: A0A8V0ZD11
uniprot id: A0A8V0ZIK6
names: Similarity
messages: Belongs to the RRM CPEB family.

9031:CTSA
gene id: 9031:CTSA
uniprot id: Q5ZIJ5
names: Similarity
messages: Belongs to the peptidase S10 family.

9031:STT3B
gene id: 9031:STT3B
uniprot id: Q5ZKX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane