868131:MSWAN RS03315
gene id: 868131:MSWAN_RS03315
uniprot id: F6D652
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

868131:MSWAN RS04440
gene id: 868131:MSWAN_RS04440
uniprot id: F6D247
names: Similarity
messages: Belongs to the thioesterase PaaI family.

868131:MSWAN RS03270
gene id: 868131:MSWAN_RS03270
uniprot id: F6D643
names: Similarity
messages: Belongs to the peptidase U62 family.

868131:MSWAN RS11330
gene id: 868131:MSWAN_RS11330
uniprot id: F6D510
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

868131:MSWAN RS11600
gene id: 868131:MSWAN_RS11600
uniprot id: F6D5X4
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS08790
gene id: 868131:MSWAN_RS08790
uniprot id: F6D4C9
names: Similarity
messages: Belongs to the UPF0111 family.

868131:MSWAN RS00210
gene id: 868131:MSWAN_RS00210
uniprot id: F6D7E8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS09730
gene id: 868131:MSWAN_RS09730
uniprot id: F6D6T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

868131:MSWAN RS01435
gene id: 868131:MSWAN_RS01435
uniprot id: F6D2H1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

868131:MSWAN RS02105
gene id: 868131:MSWAN_RS02105
uniprot id: F6D441
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

868131:MSWAN RS08685
gene id: 868131:MSWAN_RS08685
uniprot id: F6D3W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

868131:MSWAN RS11575
gene id: 868131:MSWAN_RS11575
uniprot id: F6D5W9
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS00620
gene id: 868131:MSWAN_RS00620
uniprot id: F6D827
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

868131:MSWAN RS06515
gene id: 868131:MSWAN_RS06515
uniprot id: F6D6P5
names: Cofactor
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.

868131:MSWAN RS03310
gene id: 868131:MSWAN_RS03310
uniprot id: F6D651
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS06695
gene id: 868131:MSWAN_RS06695
uniprot id: F6D6Z6
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

868131:MSWAN RS00585
gene id: 868131:MSWAN_RS00585
uniprot id: F6D820
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS07170
gene id: 868131:MSWAN_RS07170
uniprot id: F6D7J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

868131:MSWAN RS10145
gene id: 868131:MSWAN_RS10145
uniprot id: F6D2C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

868131:MSWAN RS09950
gene id: 868131:MSWAN_RS09950
uniprot id: F6D762
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

868131:MSWAN RS01340
gene id: 868131:MSWAN_RS01340
uniprot id: F6D221
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

868131:MSWAN RS01635
gene id: 868131:MSWAN_RS01635
uniprot id: F6D306
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

868131:MSWAN RS07265
gene id: 868131:MSWAN_RS07265
uniprot id: F6D7L0
names: Similarity
messages: Belongs to the SUI1 family.

868131:MSWAN RS07020
gene id: 868131:MSWAN_RS07020
uniprot id: F6D794
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

868131:MSWAN RS10030
gene id: 868131:MSWAN_RS10030
uniprot id: F6D1W5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

868131:MSWAN RS02955
gene id: 868131:MSWAN_RS02955
uniprot id: F6D5L1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

868131:MSWAN RS09100
gene id: 868131:MSWAN_RS09100
uniprot id: F6D5B5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

868131:MSWAN RS00420
gene id: 868131:MSWAN_RS00420
uniprot id: F6D7Q2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

868131:MSWAN RS01505
gene id: 868131:MSWAN_RS01505
uniprot id: F6D2I5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

868131:MSWAN RS04300
gene id: 868131:MSWAN_RS04300
uniprot id: F6D1T1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

868131:MSWAN RS07665
gene id: 868131:MSWAN_RS07665
uniprot id: F6D8C3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

868131:MSWAN RS02205
gene id: 868131:MSWAN_RS02205
uniprot id: F6D458
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

868131:MSWAN RS10075
gene id: 868131:MSWAN_RS10075
uniprot id: F6D2B5
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

868131:MSWAN RS01655
gene id: 868131:MSWAN_RS01655
uniprot id: F6D310
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

868131:MSWAN RS08815
gene id: 868131:MSWAN_RS08815
uniprot id: F6D4D4
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

868131:MSWAN RS01480
gene id: 868131:MSWAN_RS01480
uniprot id: F6D2I0
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

868131:MSWAN RS00840
gene id: 868131:MSWAN_RS00840
uniprot id: F6D1I8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

868131:MSWAN RS07105
gene id: 868131:MSWAN_RS07105
uniprot id: F6D7B1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

868131:MSWAN RS07150
gene id: 868131:MSWAN_RS07150
uniprot id: F6D7I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

868131:MSWAN RS05225
gene id: 868131:MSWAN_RS05225
uniprot id: F6D3S2
names: Similarity
messages: Belongs to the UPF0201 family.

868131:MSWAN RS03215
gene id: 868131:MSWAN_RS03215
uniprot id: F6D631
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

868131:MSWAN RS08445
gene id: 868131:MSWAN_RS08445
uniprot id: F6D3C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

868131:MSWAN RS01485
gene id: 868131:MSWAN_RS01485
uniprot id: F6D2I1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

868131:MSWAN RS10435
gene id: 868131:MSWAN_RS10435
uniprot id: F6D2Y9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

868131:MSWAN RS01995
gene id: 868131:MSWAN_RS01995
uniprot id: F6D3M4
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

868131:MSWAN RS01440
gene id: 868131:MSWAN_RS01440
uniprot id: F6D2H2
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

868131:MSWAN RS11350
gene id: 868131:MSWAN_RS11350
uniprot id: F6D514
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

868131:MSWAN RS11010
gene id: 868131:MSWAN_RS11010
uniprot id: F6D4I8
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

868131:MSWAN RS06430
gene id: 868131:MSWAN_RS06430
uniprot id: F6D698
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

868131:MSWAN RS04485
gene id: 868131:MSWAN_RS04485
uniprot id: F6D256
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS09760
gene id: 868131:MSWAN_RS09760
uniprot id: F6D6U5
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

868131:MSWAN RS02140
gene id: 868131:MSWAN_RS02140
uniprot id: F6D447
names: Subcellular Location Annotation
messages: Cytoplasm

868131:MSWAN RS03595
gene id: 868131:MSWAN_RS03595
uniprot id: F6D7H0
names: Similarity
messages: Belongs to the glutaredoxin family.

868131:MSWAN RS01910
gene id: 868131:MSWAN_RS01910
uniprot id: F6D3K8
names: Similarity
messages: Belongs to the HypD family.

868131:MSWAN RS07525
gene id: 868131:MSWAN_RS07525
uniprot id: F6D806
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

868131:MSWAN RS00960
gene id: 868131:MSWAN_RS00960
uniprot id: F6D1L2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

868131:MSWAN RS11060
gene id: 868131:MSWAN_RS11060
uniprot id: F6D4J8
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS11470
gene id: 868131:MSWAN_RS11470
uniprot id: F6D5G5
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

868131:MSWAN RS09910
gene id: 868131:MSWAN_RS09910
uniprot id: F6D754
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

868131:MSWAN RS07025
gene id: 868131:MSWAN_RS07025
uniprot id: F6D795
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

868131:MSWAN RS02420
gene id: 868131:MSWAN_RS02420
uniprot id: F6D4N6
names: Similarity
messages: Belongs to the MtxX family.

868131:MSWAN RS02325
gene id: 868131:MSWAN_RS02325
uniprot id: F6D481
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

868131:MSWAN RS05310
gene id: 868131:MSWAN_RS05310
uniprot id: F6D484
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

868131:MSWAN RS02670
gene id: 868131:MSWAN_RS02670
uniprot id: F6D537
names: Similarity
messages: Belongs to the soluble Thoeris ThsA family.

868131:MSWAN RS11235
gene id: 868131:MSWAN_RS11235
uniprot id: F6D4Z2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

868131:MSWAN RS08675
gene id: 868131:MSWAN_RS08675
uniprot id: F6D3W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

868131:MSWAN RS11300
gene id: 868131:MSWAN_RS11300
uniprot id: F6D504
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

868131:MSWAN RS05830
gene id: 868131:MSWAN_RS05830
uniprot id: F6D578
names: Function
messages: Part of a potassium transport system.

868131:MSWAN RS00200
gene id: 868131:MSWAN_RS00200
uniprot id: F6D7E6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS07450
gene id: 868131:MSWAN_RS07450
uniprot id: F6D7Z1
names: Similarity
messages: Belongs to the class-I fumarase family.

868131:MSWAN RS00665
gene id: 868131:MSWAN_RS00665
uniprot id: F6D836
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

868131:MSWAN RS11170
gene id: 868131:MSWAN_RS11170
uniprot id: F6D4Y1
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS10365
gene id: 868131:MSWAN_RS10365
uniprot id: F6D2X5
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

868131:MSWAN RS09550
gene id: 868131:MSWAN_RS09550
uniprot id: F6D6C0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

868131:MSWAN RS01605
gene id: 868131:MSWAN_RS01605
uniprot id: F6D300
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

868131:MSWAN RS11910
gene id: 868131:MSWAN_RS11910
uniprot id: F6D6G9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS11320
gene id: 868131:MSWAN_RS11320
uniprot id: F6D508
names: Similarity
messages: Belongs to the UPF0215 family.

868131:MSWAN RS11335
gene id: 868131:MSWAN_RS11335
uniprot id: F6D511
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

868131:MSWAN RS08575
gene id: 868131:MSWAN_RS08575
uniprot id: F6D3U6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS09560
gene id: 868131:MSWAN_RS09560
uniprot id: F6D6C2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

868131:MSWAN RS10510
gene id: 868131:MSWAN_RS10510
uniprot id: F6D3F2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

868131:MSWAN RS02300
gene id: 868131:MSWAN_RS02300
uniprot id: F6D476
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

868131:MSWAN RS00800
gene id: 868131:MSWAN_RS00800
uniprot id: F6D864
names: Subcellular Location Annotation
messages: Cell membrane

868131:MSWAN RS09165
gene id: 868131:MSWAN_RS09165
uniprot id: F6D5C8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

868131:MSWAN RS02495
gene id: 868131:MSWAN_RS02495
uniprot id: F6D4Q2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

868131:MSWAN RS11430
gene id: 868131:MSWAN_RS11430
uniprot id: F6D5F8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

868131:MSWAN RS02265
gene id: 868131:MSWAN_RS02265
uniprot id: F6D469
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

868131:MSWAN RS12100
gene id: 868131:MSWAN_RS12100
uniprot id: F6D6Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

868131:MSWAN RS11385
gene id: 868131:MSWAN_RS11385
uniprot id: F6D5E8
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS01915
gene id: 868131:MSWAN_RS01915
uniprot id: F6D3K9
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

868131:MSWAN RS10160
gene id: 868131:MSWAN_RS10160
uniprot id: F6D2D2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

868131:MSWAN RS07970
gene id: 868131:MSWAN_RS07970
uniprot id: F6D2A2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

868131:MSWAN RS07200
gene id: 868131:MSWAN_RS07200
uniprot id: F6D7J6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

868131:MSWAN RS05215
gene id: 868131:MSWAN_RS05215
uniprot id: F6D3S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

868131:MSWAN RS01040
gene id: 868131:MSWAN_RS01040
uniprot id: F6D1M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

868131:MSWAN RS10950
gene id: 868131:MSWAN_RS10950
uniprot id: F6D4H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

868131:MSWAN RS12230
gene id: 868131:MSWAN_RS12230
uniprot id: F6D1Q1
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

868131:MSWAN RS04500
gene id: 868131:MSWAN_RS04500
uniprot id: F6D259
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

868131:MSWAN RS02915
gene id: 868131:MSWAN_RS02915
uniprot id: F6D5K3
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS07515
gene id: 868131:MSWAN_RS07515
uniprot id: F6D804
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS09740
gene id: 868131:MSWAN_RS09740
uniprot id: F6D6U1
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

868131:MSWAN RS04470
gene id: 868131:MSWAN_RS04470
uniprot id: F6D253
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

868131:MSWAN RS01185
gene id: 868131:MSWAN_RS01185
uniprot id: F6D1Z1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

868131:MSWAN RS03590
gene id: 868131:MSWAN_RS03590
uniprot id: F6D7G9
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

868131:MSWAN RS01165
gene id: 868131:MSWAN_RS01165
uniprot id: F6D1Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

868131:MSWAN RS07090
gene id: 868131:MSWAN_RS07090
uniprot id: F6D7A8
names: Similarity
messages: Belongs to the MEMO1 family.

868131:MSWAN RS00990
gene id: 868131:MSWAN_RS00990
uniprot id: F6D1L8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

868131:MSWAN RS09540
gene id: 868131:MSWAN_RS09540
uniprot id: F6D6B8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

868131:MSWAN RS07875
gene id: 868131:MSWAN_RS07875
uniprot id: F6D282
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

868131:MSWAN RS05975
gene id: 868131:MSWAN_RS05975
uniprot id: F6D5A9
names: Similarity
messages: Belongs to the nitroreductase family.

868131:MSWAN RS00390
gene id: 868131:MSWAN_RS00390
uniprot id: F6D7P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

868131:MSWAN RS07595
gene id: 868131:MSWAN_RS07595
uniprot id: F6D8A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

868131:MSWAN RS07070
gene id: 868131:MSWAN_RS07070
uniprot id: F6D7A4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

868131:MSWAN RS02350
gene id: 868131:MSWAN_RS02350
uniprot id: F6D4M3
names: Similarity
messages: Belongs to the UPF0440 family.

868131:MSWAN RS07585
gene id: 868131:MSWAN_RS07585
uniprot id: F6D8A7
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS02480
gene id: 868131:MSWAN_RS02480
uniprot id: F6D4P9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

868131:MSWAN RS10185
gene id: 868131:MSWAN_RS10185
uniprot id: F6D2D7
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

868131:MSWAN RS02410
gene id: 868131:MSWAN_RS02410
uniprot id: F6D4N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

868131:MSWAN RS02770
gene id: 868131:MSWAN_RS02770
uniprot id: F6D557
names: Similarity
messages: Belongs to the UDPGP type 2 family.

868131:MSWAN RS01960
gene id: 868131:MSWAN_RS01960
uniprot id: F6D3L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

868131:MSWAN RS10900
gene id: 868131:MSWAN_RS10900
uniprot id: F6D431
names: Similarity
messages: Belongs to the UPF0145 family.

868131:MSWAN RS01740
gene id: 868131:MSWAN_RS01740
uniprot id: F6D326
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

868131:MSWAN RS03845
gene id: 868131:MSWAN_RS03845
uniprot id: F6D7V9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

868131:MSWAN RS01420
gene id: 868131:MSWAN_RS01420
uniprot id: F6D2G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

868131:MSWAN RS09160
gene id: 868131:MSWAN_RS09160
uniprot id: F6D5C7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

868131:MSWAN RS04560
gene id: 868131:MSWAN_RS04560
uniprot id: F6D2K3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

868131:MSWAN RS07115
gene id: 868131:MSWAN_RS07115
uniprot id: F6D7B3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

868131:MSWAN RS04540
gene id: 868131:MSWAN_RS04540
uniprot id: F6D267
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

868131:MSWAN RS08645
gene id: 868131:MSWAN_RS08645
uniprot id: F6D3W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

868131:MSWAN RS06050
gene id: 868131:MSWAN_RS06050
uniprot id: F6D5Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

868131:MSWAN RS10910
gene id: 868131:MSWAN_RS10910
uniprot id: F6D433
names: Similarity
messages: Belongs to the band 7/mec-2 family.

868131:MSWAN RS12130
gene id: 868131:MSWAN_RS12130
uniprot id: F6D6Y9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS02055
gene id: 868131:MSWAN_RS02055
uniprot id: F6D3N6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

868131:MSWAN RS06240
gene id: 868131:MSWAN_RS06240
uniprot id: F6D661
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

868131:MSWAN RS04090
gene id: 868131:MSWAN_RS04090
uniprot id: F6D1N9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

868131:MSWAN RS00440
gene id: 868131:MSWAN_RS00440
uniprot id: F6D7Q6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

868131:MSWAN RS02635
gene id: 868131:MSWAN_RS02635
uniprot id: F6D530
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

868131:MSWAN RS11905
gene id: 868131:MSWAN_RS11905
uniprot id: F6D6G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

868131:MSWAN RS09745
gene id: 868131:MSWAN_RS09745
uniprot id: F6D6U2
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

868131:MSWAN RS02490
gene id: 868131:MSWAN_RS02490
uniprot id: F6D4Q1
names: Similarity
messages: Belongs to the SAICAR synthetase family.

868131:MSWAN RS02945
gene id: 868131:MSWAN_RS02945
uniprot id: F6D5K9
names: Similarity
messages: Belongs to the HupF/HypC family.

868131:MSWAN RS02980
gene id: 868131:MSWAN_RS02980
uniprot id: F6D5L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

868131:MSWAN RS11325
gene id: 868131:MSWAN_RS11325
uniprot id: F6D509
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

868131:MSWAN RS09105
gene id: 868131:MSWAN_RS09105
uniprot id: F6D5B6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

868131:MSWAN RS11925
gene id: 868131:MSWAN_RS11925
uniprot id: F6D6H2
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

868131:MSWAN RS04870
gene id: 868131:MSWAN_RS04870
uniprot id: F6D358
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS09180
gene id: 868131:MSWAN_RS09180
uniprot id: F6D5D1
names: Similarity
messages: Belongs to the MCM family.

868131:MSWAN RS09695
gene id: 868131:MSWAN_RS09695
uniprot id: F6D6T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

868131:MSWAN RS06815
gene id: 868131:MSWAN_RS06815
uniprot id: F6D720
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS11495
gene id: 868131:MSWAN_RS11495
uniprot id: F6D5H0
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

868131:MSWAN RS08520
gene id: 868131:MSWAN_RS08520
uniprot id: F6D3E4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

868131:MSWAN RS02825
gene id: 868131:MSWAN_RS02825
uniprot id: F6D5I6
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

868131:MSWAN RS08665
gene id: 868131:MSWAN_RS08665
uniprot id: F6D3W4
names: Caution
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS08740
gene id: 868131:MSWAN_RS08740
uniprot id: F6D3Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

868131:MSWAN RS05110
gene id: 868131:MSWAN_RS05110
uniprot id: F6D3Q1
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

868131:MSWAN RS02885
gene id: 868131:MSWAN_RS02885
uniprot id: F6D5J7
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

868131:MSWAN RS07075
gene id: 868131:MSWAN_RS07075
uniprot id: F6D7A5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS08870
gene id: 868131:MSWAN_RS08870
uniprot id: F6D4E4
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

868131:MSWAN RS01570
gene id: 868131:MSWAN_RS01570
uniprot id: F6D2J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

868131:MSWAN RS08710
gene id: 868131:MSWAN_RS08710
uniprot id: F6D3X3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

868131:MSWAN RS01610
gene id: 868131:MSWAN_RS01610
uniprot id: F6D301
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

868131:MSWAN RS10920
gene id: 868131:MSWAN_RS10920
uniprot id: F6D435
names: Function
messages: Part of a potassium transport system.

868131:MSWAN RS00400
gene id: 868131:MSWAN_RS00400
uniprot id: F6D7P8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

868131:MSWAN RS05435
gene id: 868131:MSWAN_RS05435
uniprot id: F6D4A9
names: Similarity
messages: Belongs to the UPF0145 family.

868131:MSWAN RS11555
gene id: 868131:MSWAN_RS11555
uniprot id: F6D5I3
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

868131:MSWAN RS10060
gene id: 868131:MSWAN_RS10060
uniprot id: F6D1X2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

868131:MSWAN RS07710
gene id: 868131:MSWAN_RS07710
uniprot id: F6D1T9
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

868131:MSWAN RS02320
gene id: 868131:MSWAN_RS02320
uniprot id: F6D480
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

868131:MSWAN RS01970
gene id: 868131:MSWAN_RS01970
uniprot id: F6D3L9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

868131:MSWAN RS08095
gene id: 868131:MSWAN_RS08095
uniprot id: F6D2R5
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

868131:MSWAN RS02155
gene id: 868131:MSWAN_RS02155
uniprot id: F6D450
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the small carbamoyl-phosphate synthase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Catalyzes the synthesis of carbamoyl phosphate from ATP, ammonium and bicarbonate. Proceeds via a three-step mechanism, i.e. the phosphorylation of hydrogencarbonate to carboxyphosphate, a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate, and the phosphorylation of carbamate forming carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS04865
gene id: 868131:MSWAN_RS04865
uniprot id: F6D357
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

868131:MSWAN RS01595
gene id: 868131:MSWAN_RS01595
uniprot id: F6D2Z8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

868131:MSWAN RS09600
gene id: 868131:MSWAN_RS09600
uniprot id: F6D6D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

868131:MSWAN RS05220
gene id: 868131:MSWAN_RS05220
uniprot id: F6D3S1
names: Similarity
messages: Belongs to the UPF0200 family.

868131:MSWAN RS09450
gene id: 868131:MSWAN_RS09450
uniprot id: F6D6A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

868131:MSWAN RS02975
gene id: 868131:MSWAN_RS02975
uniprot id: F6D5L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

868131:MSWAN RS08610
gene id: 868131:MSWAN_RS08610
uniprot id: F6D3V3
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

868131:MSWAN RS03025
gene id: 868131:MSWAN_RS03025
uniprot id: F6D5M4
names: Subcellular Location Annotation
messages: Cell membrane

868131:MSWAN RS09040
gene id: 868131:MSWAN_RS09040
uniprot id: F6D4X3
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

868131:MSWAN RS09725
gene id: 868131:MSWAN_RS09725
uniprot id: F6D6T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

868131:MSWAN RS03455
gene id: 868131:MSWAN_RS03455
uniprot id: F6D6L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

868131:MSWAN RS09960
gene id: 868131:MSWAN_RS09960
uniprot id: F6D764
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-101 inactivates the nitrogenase reductase and regulates nitrogenase activity.

868131:MSWAN RS01965
gene id: 868131:MSWAN_RS01965
uniprot id: F6D3L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

868131:MSWAN RS03040
gene id: 868131:MSWAN_RS03040
uniprot id: F6D5M7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

868131:MSWAN RS02850
gene id: 868131:MSWAN_RS02850
uniprot id: F6D5J1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

868131:MSWAN RS09170
gene id: 868131:MSWAN_RS09170
uniprot id: F6D5C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

868131:MSWAN RS09010
gene id: 868131:MSWAN_RS09010
uniprot id: F6D4W6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

868131:MSWAN RS03360
gene id: 868131:MSWAN_RS03360
uniprot id: F6D6J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

868131:MSWAN RS11345
gene id: 868131:MSWAN_RS11345
uniprot id: F6D513
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

868131:MSWAN RS07240
gene id: 868131:MSWAN_RS07240
uniprot id: F6D7K5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

868131:MSWAN RS02880
gene id: 868131:MSWAN_RS02880
uniprot id: F6D5J6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

868131:MSWAN RS10825
gene id: 868131:MSWAN_RS10825
uniprot id: F6D416
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

868131:MSWAN RS07065
gene id: 868131:MSWAN_RS07065
uniprot id: F6D7A3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

868131:MSWAN RS01195
gene id: 868131:MSWAN_RS01195
uniprot id: F6D1Z3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

868131:MSWAN RS00140
gene id: 868131:MSWAN_RS00140
uniprot id: F6D7D3
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS12040
gene id: 868131:MSWAN_RS12040
uniprot id: F6D6X1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

868131:MSWAN RS04550
gene id: 868131:MSWAN_RS04550
uniprot id: F6D2K1
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

868131:MSWAN RS10590
gene id: 868131:MSWAN_RS10590
uniprot id: F6D3G8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS11565
gene id: 868131:MSWAN_RS11565
uniprot id: F6D5W7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

868131:MSWAN RS11520
gene id: 868131:MSWAN_RS11520
uniprot id: F6D5H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS04100
gene id: 868131:MSWAN_RS04100
uniprot id: F6D1P1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

868131:MSWAN RS01170
gene id: 868131:MSWAN_RS01170
uniprot id: F6D1Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

868131:MSWAN RS05145
gene id: 868131:MSWAN_RS05145
uniprot id: F6D3Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

868131:MSWAN RS06865
gene id: 868131:MSWAN_RS06865
uniprot id: F6D728
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS11140
gene id: 868131:MSWAN_RS11140
uniprot id: F6D4L5
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

868131:MSWAN RS00520
gene id: 868131:MSWAN_RS00520
uniprot id: F6D7S3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS06460
gene id: 868131:MSWAN_RS06460
uniprot id: F6D6N4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

868131:MSWAN RS02735
gene id: 868131:MSWAN_RS02735
uniprot id: F6D550
names: Similarity
messages: Belongs to the UPF0235 family.

868131:MSWAN RS07255
gene id: 868131:MSWAN_RS07255
uniprot id: F6D7K8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

868131:MSWAN RS03635
gene id: 868131:MSWAN_RS03635
uniprot id: F6D7H7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

868131:MSWAN RS07095
gene id: 868131:MSWAN_RS07095
uniprot id: F6D7A9
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

868131:MSWAN RS01210
gene id: 868131:MSWAN_RS01210
uniprot id: F6D1Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

868131:MSWAN RS10165
gene id: 868131:MSWAN_RS10165
uniprot id: F6D2D3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

868131:MSWAN RS06410
gene id: 868131:MSWAN_RS06410
uniprot id: F6D694
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

868131:MSWAN RS01810
gene id: 868131:MSWAN_RS01810
uniprot id: F6D341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

868131:MSWAN RS07245
gene id: 868131:MSWAN_RS07245
uniprot id: F6D7K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

868131:MSWAN RS03640
gene id: 868131:MSWAN_RS03640
uniprot id: F6D7H8
names: Similarity
messages: Belongs to the aspartokinase family.

868131:MSWAN RS10125
gene id: 868131:MSWAN_RS10125
uniprot id: F6D2C5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

868131:MSWAN RS08640
gene id: 868131:MSWAN_RS08640
uniprot id: F6D3V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

868131:MSWAN RS08435
gene id: 868131:MSWAN_RS08435
uniprot id: F6D3C7
names: Similarity
messages: Belongs to the ZPR1 family.

868131:MSWAN RS12095
gene id: 868131:MSWAN_RS12095
uniprot id: F6D6Y2
names: Similarity
messages: Belongs to the GARS family.

868131:MSWAN RS02190
gene id: 868131:MSWAN_RS02190
uniprot id: F6D455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

868131:MSWAN RS08695
gene id: 868131:MSWAN_RS08695
uniprot id: F6D3X0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

868131:MSWAN RS00195
gene id: 868131:MSWAN_RS00195
uniprot id: F6D7E5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

868131:MSWAN RS07800
gene id: 868131:MSWAN_RS07800
uniprot id: F6D268
names: Similarity
messages: Belongs to the UPF0288 family.

868131:MSWAN RS11285
gene id: 868131:MSWAN_RS11285
uniprot id: F6D501
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

868131:MSWAN RS10025
gene id: 868131:MSWAN_RS10025
uniprot id: F6D1W4
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

868131:MSWAN RS02485
gene id: 868131:MSWAN_RS02485
uniprot id: F6D4Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

868131:MSWAN RS10130
gene id: 868131:MSWAN_RS10130
uniprot id: F6D2C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

868131:MSWAN RS07185
gene id: 868131:MSWAN_RS07185
uniprot id: F6D7J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

868131:MSWAN RS10615
gene id: 868131:MSWAN_RS10615
uniprot id: F6D3H3
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

868131:MSWAN RS10175
gene id: 868131:MSWAN_RS10175
uniprot id: F6D2D5
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

868131:MSWAN RS06450
gene id: 868131:MSWAN_RS06450
uniprot id: F6D6N2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

868131:MSWAN RS10115
gene id: 868131:MSWAN_RS10115
uniprot id: F6D2C3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

868131:MSWAN RS02985
gene id: 868131:MSWAN_RS02985
uniprot id: F6D5L7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS10390
gene id: 868131:MSWAN_RS10390
uniprot id: F6D2Y0
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

868131:MSWAN RS07145
gene id: 868131:MSWAN_RS07145
uniprot id: F6D7I6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

868131:MSWAN RS07180
gene id: 868131:MSWAN_RS07180
uniprot id: F6D7J2
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS12635
gene id: 868131:MSWAN_RS12635
uniprot id: F6D701
names: Similarity
messages: Belongs to the polysaccharide synthase family.

868131:MSWAN RS07215
gene id: 868131:MSWAN_RS07215
uniprot id: F6D7J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

868131:MSWAN RS03230
gene id: 868131:MSWAN_RS03230
uniprot id: F6D635
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS03565
gene id: 868131:MSWAN_RS03565
uniprot id: F6D7G4
names: Similarity
messages: Belongs to the UPF0305 family.

868131:MSWAN RS00490
gene id: 868131:MSWAN_RS00490
uniprot id: F6D7R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

868131:MSWAN RS11420
gene id: 868131:MSWAN_RS11420
uniprot id: F6D5F6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

868131:MSWAN RS07005
gene id: 868131:MSWAN_RS07005
uniprot id: F6D791
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

868131:MSWAN RS09465
gene id: 868131:MSWAN_RS09465
uniprot id: F6D6A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

868131:MSWAN RS06925
gene id: 868131:MSWAN_RS06925
uniprot id: F6D742
names: Similarity
messages: Belongs to the intimin/invasin family.

868131:MSWAN RS13075
gene id: 868131:MSWAN_RS13075
uniprot id: F6D1U0
names: Similarity
messages: Belongs to the HdrC family.

868131:MSWAN RS01815
gene id: 868131:MSWAN_RS01815
uniprot id: F6D342
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

868131:MSWAN RS11800
gene id: 868131:MSWAN_RS11800
uniprot id: F6D6E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

868131:MSWAN RS00885
gene id: 868131:MSWAN_RS00885
uniprot id: F6D1J7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

868131:MSWAN RS06485
gene id: 868131:MSWAN_RS06485
uniprot id: F6D6N9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

868131:MSWAN RS12085
gene id: 868131:MSWAN_RS12085
uniprot id: F6D6Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

868131:MSWAN RS12090
gene id: 868131:MSWAN_RS12090
uniprot id: F6D6Y1
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

868131:MSWAN RS11510
gene id: 868131:MSWAN_RS11510
uniprot id: F6D5H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

868131:MSWAN RS00750
gene id: 868131:MSWAN_RS00750
uniprot id: F6D854
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

868131:MSWAN RS00875
gene id: 868131:MSWAN_RS00875
uniprot id: F6D1J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

868131:MSWAN RS06055
gene id: 868131:MSWAN_RS06055
uniprot id: F6D5Q1
names: Similarity
messages: Belongs to the UPF0179 family.

868131:MSWAN RS11445
gene id: 868131:MSWAN_RS11445
uniprot id: F6D5G0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

868131:MSWAN RS07300
gene id: 868131:MSWAN_RS07300
uniprot id: F6D7L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

868131:MSWAN RS12105
gene id: 868131:MSWAN_RS12105
uniprot id: F6D6Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

868131:MSWAN RS10135
gene id: 868131:MSWAN_RS10135
uniprot id: F6D2C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

868131:MSWAN RS01475
gene id: 868131:MSWAN_RS01475
uniprot id: F6D2H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

868131:MSWAN RS10050
gene id: 868131:MSWAN_RS10050
uniprot id: F6D1X0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

868131:MSWAN RS02610
gene id: 868131:MSWAN_RS02610
uniprot id: F6D525
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS06285
gene id: 868131:MSWAN_RS06285
uniprot id: F6D669
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

868131:MSWAN RS06085
gene id: 868131:MSWAN_RS06085
uniprot id: F6D5Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

868131:MSWAN RS07510
gene id: 868131:MSWAN_RS07510
uniprot id: F6D804
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS09660
gene id: 868131:MSWAN_RS09660
uniprot id: F6D6S5
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

868131:MSWAN RS08800
gene id: 868131:MSWAN_RS08800
uniprot id: F6D4D1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

868131:MSWAN RS07250
gene id: 868131:MSWAN_RS07250
uniprot id: F6D7K7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

868131:MSWAN RS11210
gene id: 868131:MSWAN_RS11210
uniprot id: F6D4Y8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

868131:MSWAN RS06235
gene id: 868131:MSWAN_RS06235
uniprot id: F6D660
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS06140
gene id: 868131:MSWAN_RS06140
uniprot id: F6D5S1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

868131:MSWAN RS07925
gene id: 868131:MSWAN_RS07925
uniprot id: F6D292
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

868131:MSWAN RS07640
gene id: 868131:MSWAN_RS07640
uniprot id: F6D8B9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

868131:MSWAN RS08480
gene id: 868131:MSWAN_RS08480
uniprot id: F6D3D6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

868131:MSWAN RS09095
gene id: 868131:MSWAN_RS09095
uniprot id: F6D5B4
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

868131:MSWAN RS06120
gene id: 868131:MSWAN_RS06120
uniprot id: F6D5R7
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

868131:MSWAN RS01415
gene id: 868131:MSWAN_RS01415
uniprot id: F6D2G7
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

868131:MSWAN RS00030
gene id: 868131:MSWAN_RS00030
uniprot id: F6D776
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

868131:MSWAN RS07060
gene id: 868131:MSWAN_RS07060
uniprot id: F6D7A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

868131:MSWAN RS04435
gene id: 868131:MSWAN_RS04435
uniprot id: F6D246
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

868131:MSWAN RS02820
gene id: 868131:MSWAN_RS02820
uniprot id: F6D5I5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

868131:MSWAN RS01935
gene id: 868131:MSWAN_RS01935
uniprot id: F6D3L2
names: Caution
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS00125
gene id: 868131:MSWAN_RS00125
uniprot id: F6D7D0
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

868131:MSWAN RS01985
gene id: 868131:MSWAN_RS01985
uniprot id: F6D3M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

868131:MSWAN RS07285
gene id: 868131:MSWAN_RS07285
uniprot id: F6D7L4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

868131:MSWAN RS06070
gene id: 868131:MSWAN_RS06070
uniprot id: F6D5Q6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homooctamer.

868131:MSWAN RS01975
gene id: 868131:MSWAN_RS01975
uniprot id: F6D3M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

868131:MSWAN RS09635
gene id: 868131:MSWAN_RS09635
uniprot id: F6D6D7
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

868131:MSWAN RS08535
gene id: 868131:MSWAN_RS08535
uniprot id: F6D3T7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS10325
gene id: 868131:MSWAN_RS10325
uniprot id: F6D2W7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

868131:MSWAN RS11500
gene id: 868131:MSWAN_RS11500
uniprot id: F6D5H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

868131:MSWAN RS07590
gene id: 868131:MSWAN_RS07590
uniprot id: F6D8A8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

868131:MSWAN RS02450
gene id: 868131:MSWAN_RS02450
uniprot id: F6D4P3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

868131:MSWAN RS08615
gene id: 868131:MSWAN_RS08615
uniprot id: F6D3V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

868131:MSWAN RS09680
gene id: 868131:MSWAN_RS09680
uniprot id: F6D6S9
names: Similarity
messages: Belongs to the UPF0145 family.

868131:MSWAN RS03330
gene id: 868131:MSWAN_RS03330
uniprot id: F6D6J0
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS04535
gene id: 868131:MSWAN_RS04535
uniprot id: F6D266
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

868131:MSWAN RS00645
gene id: 868131:MSWAN_RS00645
uniprot id: F6D832
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

868131:MSWAN RS10885
gene id: 868131:MSWAN_RS10885
uniprot id: F6D428
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

868131:MSWAN RS09055
gene id: 868131:MSWAN_RS09055
uniprot id: F6D4X6
names: Similarity
messages: Belongs to the TPP enzyme family.

868131:MSWAN RS10865
gene id: 868131:MSWAN_RS10865
uniprot id: F6D424
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS03120
gene id: 868131:MSWAN_RS03120
uniprot id: F6D611
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

868131:MSWAN RS11780
gene id: 868131:MSWAN_RS11780
uniprot id: F6D6E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

868131:MSWAN RS09565
gene id: 868131:MSWAN_RS09565
uniprot id: F6D6C3
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS03370
gene id: 868131:MSWAN_RS03370
uniprot id: F6D6J7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

868131:MSWAN RS02425
gene id: 868131:MSWAN_RS02425
uniprot id: F6D4N7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS02355
gene id: 868131:MSWAN_RS02355
uniprot id: F6D4M4
names: Similarity
messages: Belongs to the HisA/HisF family.

868131:MSWAN RS03015
gene id: 868131:MSWAN_RS03015
uniprot id: F6D5M2
names: Similarity
messages: Belongs to the glutamate synthase family.

868131:MSWAN RS04680
gene id: 868131:MSWAN_RS04680
uniprot id: F6D2M7
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS03645
gene id: 868131:MSWAN_RS03645
uniprot id: F6D7H9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

868131:MSWAN RS10155
gene id: 868131:MSWAN_RS10155
uniprot id: F6D2D1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

868131:MSWAN RS11855
gene id: 868131:MSWAN_RS11855
uniprot id: F6D6F8
names: Similarity
messages: Belongs to the malic enzymes family.

868131:MSWAN RS06075
gene id: 868131:MSWAN_RS06075
uniprot id: F6D5Q7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

868131:MSWAN RS00485
gene id: 868131:MSWAN_RS00485
uniprot id: F6D7R6
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

868131:MSWAN RS05360
gene id: 868131:MSWAN_RS05360
uniprot id: F6D494
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

868131:MSWAN RS08890
gene id: 868131:MSWAN_RS08890
uniprot id: F6D4E8
names: Function
messages: Could be involved in the regulation of nitrogen fixation.

868131:MSWAN RS03005
gene id: 868131:MSWAN_RS03005
uniprot id: F6D5M0
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

868131:MSWAN RS08620
gene id: 868131:MSWAN_RS08620
uniprot id: F6D3V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

868131:MSWAN RS00540
gene id: 868131:MSWAN_RS00540
uniprot id: F6D811
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

868131:MSWAN RS08580
gene id: 868131:MSWAN_RS08580
uniprot id: F6D3U7
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

868131:MSWAN RS06385
gene id: 868131:MSWAN_RS06385
uniprot id: F6D689
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

868131:MSWAN RS00545
gene id: 868131:MSWAN_RS00545
uniprot id: F6D812
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

868131:MSWAN RS10170
gene id: 868131:MSWAN_RS10170
uniprot id: F6D2D4
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

868131:MSWAN RS12115
gene id: 868131:MSWAN_RS12115
uniprot id: F6D6Y6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS11185
gene id: 868131:MSWAN_RS11185
uniprot id: F6D4Y4
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS05275
gene id: 868131:MSWAN_RS05275
uniprot id: F6D3T2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

868131:MSWAN RS09945
gene id: 868131:MSWAN_RS09945
uniprot id: F6D761
names: Function
names: Subunit
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

868131:MSWAN RS08630
gene id: 868131:MSWAN_RS08630
uniprot id: F6D3V7
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

868131:MSWAN RS00285
gene id: 868131:MSWAN_RS00285
uniprot id: F6D7M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

868131:MSWAN RS07765
gene id: 868131:MSWAN_RS07765
uniprot id: F6D1V1
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

868131:MSWAN RS01745
gene id: 868131:MSWAN_RS01745
uniprot id: F6D328
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS11275
gene id: 868131:MSWAN_RS11275
uniprot id: F6D4Z9
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

868131:MSWAN RS00315
gene id: 868131:MSWAN_RS00315
uniprot id: F6D7N1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

868131:MSWAN RS10485
gene id: 868131:MSWAN_RS10485
uniprot id: F6D3E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

868131:MSWAN RS07605
gene id: 868131:MSWAN_RS07605
uniprot id: F6D8B1
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS09940
gene id: 868131:MSWAN_RS09940
uniprot id: F6D760
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

868131:MSWAN RS05345
gene id: 868131:MSWAN_RS05345
uniprot id: F6D491
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

868131:MSWAN RS00650
gene id: 868131:MSWAN_RS00650
uniprot id: F6D833
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

868131:MSWAN RS04315
gene id: 868131:MSWAN_RS04315
uniprot id: F6D1T4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

868131:MSWAN RS00660
gene id: 868131:MSWAN_RS00660
uniprot id: F6D835
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS10620
gene id: 868131:MSWAN_RS10620
uniprot id: F6D3H4
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS03235
gene id: 868131:MSWAN_RS03235
uniprot id: F6D636
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

868131:MSWAN RS10350
gene id: 868131:MSWAN_RS10350
uniprot id: F6D2X2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

868131:MSWAN RS02315
gene id: 868131:MSWAN_RS02315
uniprot id: F6D479
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

868131:MSWAN RS08670
gene id: 868131:MSWAN_RS08670
uniprot id: F6D3W5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

868131:MSWAN RS01130
gene id: 868131:MSWAN_RS01130
uniprot id: F6D1Y5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

868131:MSWAN RS05920
gene id: 868131:MSWAN_RS05920
uniprot id: F6D597
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

868131:MSWAN RS01665
gene id: 868131:MSWAN_RS01665
uniprot id: F6D312
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

868131:MSWAN RS00090
gene id: 868131:MSWAN_RS00090
uniprot id: F6D7C3
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

868131:MSWAN RS03225
gene id: 868131:MSWAN_RS03225
uniprot id: F6D634
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

868131:MSWAN RS01800
gene id: 868131:MSWAN_RS01800
uniprot id: F6D339
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

868131:MSWAN RS07160
gene id: 868131:MSWAN_RS07160
uniprot id: F6D7I8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

868131:MSWAN RS01565
gene id: 868131:MSWAN_RS01565
uniprot id: F6D2J8
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

868131:MSWAN RS02860
gene id: 868131:MSWAN_RS02860
uniprot id: F6D5J3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

868131:MSWAN RS08490
gene id: 868131:MSWAN_RS08490
uniprot id: F6D3D8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

868131:MSWAN RS08700
gene id: 868131:MSWAN_RS08700
uniprot id: F6D3X1
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

868131:MSWAN RS00115
gene id: 868131:MSWAN_RS00115
uniprot id: F6D7C8
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Homodimer.

868131:MSWAN RS03625
gene id: 868131:MSWAN_RS03625
uniprot id: F6D7H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

868131:MSWAN RS02260
gene id: 868131:MSWAN_RS02260
uniprot id: F6D468
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

868131:MSWAN RS07530
gene id: 868131:MSWAN_RS07530
uniprot id: F6D807
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

868131:MSWAN RS10235
gene id: 868131:MSWAN_RS10235
uniprot id: F6D2E6
names: Similarity
messages: Belongs to the ComB family.

868131:MSWAN RS09515
gene id: 868131:MSWAN_RS09515
uniprot id: F6D6B3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

868131:MSWAN RS09805
gene id: 868131:MSWAN_RS09805
uniprot id: F6D6V4
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS12640
gene id: 868131:MSWAN_RS12640
uniprot id: F6D702
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

868131:MSWAN RS02900
gene id: 868131:MSWAN_RS02900
uniprot id: F6D5K0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

868131:MSWAN RS08455
gene id: 868131:MSWAN_RS08455
uniprot id: F6D3D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

868131:MSWAN RS09325
gene id: 868131:MSWAN_RS09325
uniprot id: F6D5U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

868131:MSWAN RS08850
gene id: 868131:MSWAN_RS08850
uniprot id: F6D4E0
names: Similarity
messages: Belongs to the glutamate synthase family.

868131:MSWAN RS07125
gene id: 868131:MSWAN_RS07125
uniprot id: F6D7I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

868131:MSWAN RS02540
gene id: 868131:MSWAN_RS02540
uniprot id: F6D4R0
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

868131:MSWAN RS01080
gene id: 868131:MSWAN_RS01080
uniprot id: F6D1X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

868131:MSWAN RS03095
gene id: 868131:MSWAN_RS03095
uniprot id: F6D606
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

868131:MSWAN RS09185
gene id: 868131:MSWAN_RS09185
uniprot id: F6D5D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

868131:MSWAN RS07535
gene id: 868131:MSWAN_RS07535
uniprot id: F6D808
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS02305
gene id: 868131:MSWAN_RS02305
uniprot id: F6D477
names: Similarity
messages: Belongs to the SDO1/SBDS family.

868131:MSWAN RS09285
gene id: 868131:MSWAN_RS09285
uniprot id: F6D5U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

868131:MSWAN RS08365
gene id: 868131:MSWAN_RS08365
uniprot id: F6D3B3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

868131:MSWAN RS00020
gene id: 868131:MSWAN_RS00020
uniprot id: F6D774
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

868131:MSWAN RS00180
gene id: 868131:MSWAN_RS00180
uniprot id: F6D7E2
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS07675
gene id: 868131:MSWAN_RS07675
uniprot id: F6D8C5
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

868131:MSWAN RS10535
gene id: 868131:MSWAN_RS10535
uniprot id: F6D3F7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS03660
gene id: 868131:MSWAN_RS03660
uniprot id: F6D7S6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS08715
gene id: 868131:MSWAN_RS08715
uniprot id: F6D3X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

868131:MSWAN RS06480
gene id: 868131:MSWAN_RS06480
uniprot id: F6D6N8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

868131:MSWAN RS10005
gene id: 868131:MSWAN_RS10005
uniprot id: F6D1W0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

868131:MSWAN RS07975
gene id: 868131:MSWAN_RS07975
uniprot id: F6D2A3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

868131:MSWAN RS07465
gene id: 868131:MSWAN_RS07465
uniprot id: F6D7Z4
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

868131:MSWAN RS11715
gene id: 868131:MSWAN_RS11715
uniprot id: F6D5Z6
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

868131:MSWAN RS10335
gene id: 868131:MSWAN_RS10335
uniprot id: F6D2W9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

868131:MSWAN RS10760
gene id: 868131:MSWAN_RS10760
uniprot id: F6D403
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS01350
gene id: 868131:MSWAN_RS01350
uniprot id: F6D223
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

868131:MSWAN RS09845
gene id: 868131:MSWAN_RS09845
uniprot id: F6D6W3
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS11290
gene id: 868131:MSWAN_RS11290
uniprot id: F6D502
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

868131:MSWAN RS01025
gene id: 868131:MSWAN_RS01025
uniprot id: F6D1M5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

868131:MSWAN RS07270
gene id: 868131:MSWAN_RS07270
uniprot id: F6D7L1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

868131:MSWAN RS11475
gene id: 868131:MSWAN_RS11475
uniprot id: F6D5G6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS00425
gene id: 868131:MSWAN_RS00425
uniprot id: F6D7Q3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

868131:MSWAN RS10370
gene id: 868131:MSWAN_RS10370
uniprot id: F6D2X6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

868131:MSWAN RS06560
gene id: 868131:MSWAN_RS06560
uniprot id: F6D6Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

868131:MSWAN RS10830
gene id: 868131:MSWAN_RS10830
uniprot id: F6D417
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

868131:MSWAN RS09150
gene id: 868131:MSWAN_RS09150
uniprot id: F6D5C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

868131:MSWAN RS07205
gene id: 868131:MSWAN_RS07205
uniprot id: F6D7J7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

868131:MSWAN RS11225
gene id: 868131:MSWAN_RS11225
uniprot id: F6D4Z0
names: Similarity
messages: Belongs to the FrhG family.

868131:MSWAN RS06940
gene id: 868131:MSWAN_RS06940
uniprot id: F6D744
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

868131:MSWAN RS10700
gene id: 868131:MSWAN_RS10700
uniprot id: F6D3Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

868131:MSWAN RS07335
gene id: 868131:MSWAN_RS07335
uniprot id: F6D7W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

868131:MSWAN RS05935
gene id: 868131:MSWAN_RS05935
uniprot id: F6D5A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

868131:MSWAN RS11490
gene id: 868131:MSWAN_RS11490
uniprot id: F6D5G9
names: Similarity
messages: Belongs to the replication factor A protein 1 family.

868131:MSWAN RS09980
gene id: 868131:MSWAN_RS09980
uniprot id: F6D768
names: Similarity
messages: Belongs to the LarC family.

868131:MSWAN RS05315
gene id: 868131:MSWAN_RS05315
uniprot id: F6D485
names: Similarity
messages: Belongs to the peptidase C56 family.

868131:MSWAN RS11955
gene id: 868131:MSWAN_RS11955
uniprot id: F6D6H8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

868131:MSWAN RS01270
gene id: 868131:MSWAN_RS01270
uniprot id: F6D207
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

868131:MSWAN RS09625
gene id: 868131:MSWAN_RS09625
uniprot id: F6D6D5
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS11130
gene id: 868131:MSWAN_RS11130
uniprot id: F6D4L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

868131:MSWAN RS07210
gene id: 868131:MSWAN_RS07210
uniprot id: F6D7J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

868131:MSWAN RS07220
gene id: 868131:MSWAN_RS07220
uniprot id: F6D7K0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

868131:MSWAN RS00530
gene id: 868131:MSWAN_RS00530
uniprot id: F6D809
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

868131:MSWAN RS08375
gene id: 868131:MSWAN_RS08375
uniprot id: F6D3B5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

868131:MSWAN RS09735
gene id: 868131:MSWAN_RS09735
uniprot id: F6D6U0
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

868131:MSWAN RS09090
gene id: 868131:MSWAN_RS09090
uniprot id: F6D5B3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

868131:MSWAN RS12045
gene id: 868131:MSWAN_RS12045
uniprot id: F6D6X2
names: Similarity
messages: Belongs to the UPF0251 family.

868131:MSWAN RS00745
gene id: 868131:MSWAN_RS00745
uniprot id: F6D853
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS10420
gene id: 868131:MSWAN_RS10420
uniprot id: F6D2Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

868131:MSWAN RS03205
gene id: 868131:MSWAN_RS03205
uniprot id: F6D629
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

868131:MSWAN RS01120
gene id: 868131:MSWAN_RS01120
uniprot id: F6D1Y3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

868131:MSWAN RS03105
gene id: 868131:MSWAN_RS03105
uniprot id: F6D608
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

868131:MSWAN RS08705
gene id: 868131:MSWAN_RS08705
uniprot id: F6D3X2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

868131:MSWAN RS02390
gene id: 868131:MSWAN_RS02390
uniprot id: F6D4N0
names: Similarity
messages: Belongs to the HypE family.

868131:MSWAN RS11280
gene id: 868131:MSWAN_RS11280
uniprot id: F6D500
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

868131:MSWAN RS03285
gene id: 868131:MSWAN_RS03285
uniprot id: F6D646
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

868131:MSWAN RS10880
gene id: 868131:MSWAN_RS10880
uniprot id: F6D427
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

868131:MSWAN RS11895
gene id: 868131:MSWAN_RS11895
uniprot id: F6D6G6
names: Caution
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

868131:MSWAN RS02335
gene id: 868131:MSWAN_RS02335
uniprot id: F6D4M0
names: Function
messages: Probably involved in the biogenesis of the ribosome.

868131:MSWAN RS10595
gene id: 868131:MSWAN_RS10595
uniprot id: F6D3G9
names: Cofactor
messages: Binds 1 zinc ion per subunit.

868131:MSWAN RS02290
gene id: 868131:MSWAN_RS02290
uniprot id: F6D474
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

868131:MSWAN RS09755
gene id: 868131:MSWAN_RS09755
uniprot id: F6D6U4
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

868131:MSWAN RS07235
gene id: 868131:MSWAN_RS07235
uniprot id: F6D7K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

868131:MSWAN RS06920
gene id: 868131:MSWAN_RS06920
uniprot id: F6D741
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

868131:MSWAN RS04515
gene id: 868131:MSWAN_RS04515
uniprot id: F6D262
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS09035
gene id: 868131:MSWAN_RS09035
uniprot id: F6D4X1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

868131:MSWAN RS04425
gene id: 868131:MSWAN_RS04425
uniprot id: F6D244
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

868131:MSWAN RS07055
gene id: 868131:MSWAN_RS07055
uniprot id: F6D7A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

868131:MSWAN RS11990
gene id: 868131:MSWAN_RS11990
uniprot id: F6D6I5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

868131:MSWAN RS00495
gene id: 868131:MSWAN_RS00495
uniprot id: F6D7R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

868131:MSWAN RS11360
gene id: 868131:MSWAN_RS11360
uniprot id: F6D516
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

868131:MSWAN RS02810
gene id: 868131:MSWAN_RS02810
uniprot id: F6D565
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

868131:MSWAN RS03465
gene id: 868131:MSWAN_RS03465
uniprot id: F6D6L4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

868131:MSWAN RS01875
gene id: 868131:MSWAN_RS01875
uniprot id: F6D3K1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

868131:MSWAN RS11310
gene id: 868131:MSWAN_RS11310
uniprot id: F6D506
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

868131:MSWAN RS07820
gene id: 868131:MSWAN_RS07820
uniprot id: F6D272
names: Similarity
messages: Belongs to the MoaB/Mog family.

868131:MSWAN RS12020
gene id: 868131:MSWAN_RS12020
uniprot id: F6D6W9
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

868131:MSWAN RS03320
gene id: 868131:MSWAN_RS03320
uniprot id: F6D6I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

868131:MSWAN RS08865
gene id: 868131:MSWAN_RS08865
uniprot id: F6D4E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

868131:MSWAN RS08855
gene id: 868131:MSWAN_RS08855
uniprot id: F6D4E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

868131:MSWAN RS10260
gene id: 868131:MSWAN_RS10260
uniprot id: F6D2F1
names: Similarity
messages: Belongs to the UPF0045 family.

868131:MSWAN RS07280
gene id: 868131:MSWAN_RS07280
uniprot id: F6D7L3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

868131:MSWAN RS00240
gene id: 868131:MSWAN_RS00240
uniprot id: F6D7F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Belongs to the MvhD/VhuD family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

868131:MSWAN RS07225
gene id: 868131:MSWAN_RS07225
uniprot id: F6D7K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

868131:MSWAN RS07130
gene id: 868131:MSWAN_RS07130
uniprot id: F6D7I3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

868131:MSWAN RS09120
gene id: 868131:MSWAN_RS09120
uniprot id: F6D5B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

868131:MSWAN RS05720
gene id: 868131:MSWAN_RS05720
uniprot id: F6D4V5
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS03150
gene id: 868131:MSWAN_RS03150
uniprot id: F6D617
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS06260
gene id: 868131:MSWAN_RS06260
uniprot id: F6D665
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

868131:MSWAN RS11945
gene id: 868131:MSWAN_RS11945
uniprot id: F6D6H6
names: Similarity
messages: Belongs to the UPF0147 family.

868131:MSWAN RS09195
gene id: 868131:MSWAN_RS09195
uniprot id: F6D5D4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS05305
gene id: 868131:MSWAN_RS05305
uniprot id: F6D483
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

868131:MSWAN RS02710
gene id: 868131:MSWAN_RS02710
uniprot id: F6D546
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

868131:MSWAN RS07485
gene id: 868131:MSWAN_RS07485
uniprot id: F6D7Z8
names: Similarity
messages: Belongs to the UPF0173 family.

868131:MSWAN RS04350
gene id: 868131:MSWAN_RS04350
uniprot id: F6D229
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

868131:MSWAN RS02150
gene id: 868131:MSWAN_RS02150
uniprot id: F6D449
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS07965
gene id: 868131:MSWAN_RS07965
uniprot id: F6D2A1
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

868131:MSWAN RS09815
gene id: 868131:MSWAN_RS09815
uniprot id: F6D6V6
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS08860
gene id: 868131:MSWAN_RS08860
uniprot id: F6D4E2
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

868131:MSWAN RS09585
gene id: 868131:MSWAN_RS09585
uniprot id: F6D6C7
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

868131:MSWAN RS03385
gene id: 868131:MSWAN_RS03385
uniprot id: F6D6K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

868131:MSWAN RS01710
gene id: 868131:MSWAN_RS01710
uniprot id: F6D321
names: Similarity
messages: Belongs to the AHA1 family.

868131:MSWAN RS05855
gene id: 868131:MSWAN_RS05855
uniprot id: F6D584
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

868131:MSWAN RS09140
gene id: 868131:MSWAN_RS09140
uniprot id: F6D5C3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS02280
gene id: 868131:MSWAN_RS02280
uniprot id: F6D472
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

868131:MSWAN RS09535
gene id: 868131:MSWAN_RS09535
uniprot id: F6D6B7
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

868131:MSWAN RS06710
gene id: 868131:MSWAN_RS06710
uniprot id: F6D6Z9
names: Similarity
messages: Belongs to the peptidase C1 family.

868131:MSWAN RS05625
gene id: 868131:MSWAN_RS05625
uniprot id: F6D4T6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

868131:MSWAN RS08495
gene id: 868131:MSWAN_RS08495
uniprot id: F6D3D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

868131:MSWAN RS01105
gene id: 868131:MSWAN_RS01105
uniprot id: F6D1Y0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

868131:MSWAN RS10875
gene id: 868131:MSWAN_RS10875
uniprot id: F6D426
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

868131:MSWAN RS11505
gene id: 868131:MSWAN_RS11505
uniprot id: F6D5H2
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS00040
gene id: 868131:MSWAN_RS00040
uniprot id: F6D7B4
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

868131:MSWAN RS00095
gene id: 868131:MSWAN_RS00095
uniprot id: F6D7C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

868131:MSWAN RS08380
gene id: 868131:MSWAN_RS08380
uniprot id: F6D3B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

868131:MSWAN RS00830
gene id: 868131:MSWAN_RS00830
uniprot id: F6D1I6
names: Similarity
messages: Belongs to the group II decarboxylase family.

868131:MSWAN RS10815
gene id: 868131:MSWAN_RS10815
uniprot id: F6D414
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

868131:MSWAN RS03305
gene id: 868131:MSWAN_RS03305
uniprot id: F6D650
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

868131:MSWAN RS04430
gene id: 868131:MSWAN_RS04430
uniprot id: F6D245
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS03220
gene id: 868131:MSWAN_RS03220
uniprot id: F6D633
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

868131:MSWAN RS07755
gene id: 868131:MSWAN_RS07755
uniprot id: F6D1U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

868131:MSWAN RS00335
gene id: 868131:MSWAN_RS00335
uniprot id: F6D7N5
names: Similarity
messages: Belongs to the SfsA family.

868131:MSWAN RS02385
gene id: 868131:MSWAN_RS02385
uniprot id: F6D4M9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

868131:MSWAN RS01215
gene id: 868131:MSWAN_RS01215
uniprot id: F6D1Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

868131:MSWAN RS08585
gene id: 868131:MSWAN_RS08585
uniprot id: F6D3U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

868131:MSWAN RS06115
gene id: 868131:MSWAN_RS06115
uniprot id: F6D5R6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

868131:MSWAN RS01345
gene id: 868131:MSWAN_RS01345
uniprot id: F6D222
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS01015
gene id: 868131:MSWAN_RS01015
uniprot id: F6D1M3
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

868131:MSWAN RS09000
gene id: 868131:MSWAN_RS09000
uniprot id: F6D4H2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

868131:MSWAN RS07880
gene id: 868131:MSWAN_RS07880
uniprot id: F6D283
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS05575
gene id: 868131:MSWAN_RS05575
uniprot id: F6D4S6
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS12075
gene id: 868131:MSWAN_RS12075
uniprot id: F6D6X8
names: Similarity
messages: Belongs to the UPF0285 family.

868131:MSWAN RS05020
gene id: 868131:MSWAN_RS05020
uniprot id: F6D388
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Belongs to the MvhD/VhuD family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

868131:MSWAN RS03020
gene id: 868131:MSWAN_RS03020
uniprot id: F6D5M3
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

868131:MSWAN RS07080
gene id: 868131:MSWAN_RS07080
uniprot id: F6D7A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

868131:MSWAN RS11370
gene id: 868131:MSWAN_RS11370
uniprot id: F6D518
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

868131:MSWAN RS11480
gene id: 868131:MSWAN_RS11480
uniprot id: F6D5G7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

868131:MSWAN RS11840
gene id: 868131:MSWAN_RS11840
uniprot id: F6D6F5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

868131:MSWAN RS03570
gene id: 868131:MSWAN_RS03570
uniprot id: F6D7G5
names: Similarity
messages: Belongs to the UPF0305 family.

868131:MSWAN RS08805
gene id: 868131:MSWAN_RS08805
uniprot id: F6D4D2
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

868131:MSWAN RS04880
gene id: 868131:MSWAN_RS04880
uniprot id: F6D360
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

868131:MSWAN RS11135
gene id: 868131:MSWAN_RS11135
uniprot id: F6D4L4
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

868131:MSWAN RS11655
gene id: 868131:MSWAN_RS11655
uniprot id: F6D5Y5
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

868131:MSWAN RS07175
gene id: 868131:MSWAN_RS07175
uniprot id: F6D7J1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

868131:MSWAN RS10810
gene id: 868131:MSWAN_RS10810
uniprot id: F6D413
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS07140
gene id: 868131:MSWAN_RS07140
uniprot id: F6D7I5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

868131:MSWAN RS10360
gene id: 868131:MSWAN_RS10360
uniprot id: F6D2X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

868131:MSWAN RS00950
gene id: 868131:MSWAN_RS00950
uniprot id: F6D1L0
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

868131:MSWAN RS09435
gene id: 868131:MSWAN_RS09435
uniprot id: F6D699
names: Similarity
messages: Belongs to the class-I fumarase family.

868131:MSWAN RS08830
gene id: 868131:MSWAN_RS08830
uniprot id: F6D4D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

868131:MSWAN RS09210
gene id: 868131:MSWAN_RS09210
uniprot id: F6D5D7
names: Similarity
messages: Belongs to the thymidylate kinase family.

868131:MSWAN RS11695
gene id: 868131:MSWAN_RS11695
uniprot id: F6D5Z2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

868131:MSWAN RS01880
gene id: 868131:MSWAN_RS01880
uniprot id: F6D3K2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

868131:MSWAN RS00790
gene id: 868131:MSWAN_RS00790
uniprot id: F6D862
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

868131:MSWAN RS01425
gene id: 868131:MSWAN_RS01425
uniprot id: F6D2G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

868131:MSWAN RS04975
gene id: 868131:MSWAN_RS04975
uniprot id: F6D380
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

868131:MSWAN RS09410
gene id: 868131:MSWAN_RS09410
uniprot id: F6D5W2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

868131:MSWAN RS09130
gene id: 868131:MSWAN_RS09130
uniprot id: F6D5C1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

868131:MSWAN RS07730
gene id: 868131:MSWAN_RS07730
uniprot id: F6D1U4
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS07500
gene id: 868131:MSWAN_RS07500
uniprot id: F6D801
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS11460
gene id: 868131:MSWAN_RS11460
uniprot id: F6D5G3
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

868131:MSWAN RS04490
gene id: 868131:MSWAN_RS04490
uniprot id: F6D257
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

868131:MSWAN RS11645
gene id: 868131:MSWAN_RS11645
uniprot id: F6D5Y3
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

868131:MSWAN RS09710
gene id: 868131:MSWAN_RS09710
uniprot id: F6D6T5
names: Similarity
messages: Belongs to the class-I fumarase family.

868131:MSWAN RS08755
gene id: 868131:MSWAN_RS08755
uniprot id: F6D3Y3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

868131:MSWAN RS04575
gene id: 868131:MSWAN_RS04575
uniprot id: F6D2K6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

868131:MSWAN RS06220
gene id: 868131:MSWAN_RS06220
uniprot id: F6D657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

868131:MSWAN RS09935
gene id: 868131:MSWAN_RS09935
uniprot id: F6D759
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

868131:MSWAN RS08900
gene id: 868131:MSWAN_RS08900
uniprot id: F6D4F0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

868131:MSWAN RS07305
gene id: 868131:MSWAN_RS07305
uniprot id: F6D7L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

868131:MSWAN RS02195
gene id: 868131:MSWAN_RS02195
uniprot id: F6D456
names: Function
messages: Part of a potassium transport system.

868131:MSWAN RS01540
gene id: 868131:MSWAN_RS01540
uniprot id: F6D2J2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

868131:MSWAN RS09355
gene id: 868131:MSWAN_RS09355
uniprot id: F6D5V2
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS08750
gene id: 868131:MSWAN_RS08750
uniprot id: F6D3Y2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

868131:MSWAN RS06135
gene id: 868131:MSWAN_RS06135
uniprot id: F6D5S0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

868131:MSWAN RS02095
gene id: 868131:MSWAN_RS02095
uniprot id: F6D439
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

868131:MSWAN RS09135
gene id: 868131:MSWAN_RS09135
uniprot id: F6D5C2
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS11090
gene id: 868131:MSWAN_RS11090
uniprot id: F6D4K4
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

868131:MSWAN RS00780
gene id: 868131:MSWAN_RS00780
uniprot id: F6D860
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS09555
gene id: 868131:MSWAN_RS09555
uniprot id: F6D6C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

868131:MSWAN RS09955
gene id: 868131:MSWAN_RS09955
uniprot id: F6D763
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

868131:MSWAN RS02080
gene id: 868131:MSWAN_RS02080
uniprot id: F6D3P1
names: Similarity
messages: Belongs to the UPF0146 family.

868131:MSWAN RS01585
gene id: 868131:MSWAN_RS01585
uniprot id: F6D2Z6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS10915
gene id: 868131:MSWAN_RS10915
uniprot id: F6D434
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS10265
gene id: 868131:MSWAN_RS10265
uniprot id: F6D2F2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

868131:MSWAN RS11560
gene id: 868131:MSWAN_RS11560
uniprot id: F6D5I4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

868131:MSWAN RS10500
gene id: 868131:MSWAN_RS10500
uniprot id: F6D3F0
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

868131:MSWAN RS05445
gene id: 868131:MSWAN_RS05445
uniprot id: F6D4B1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

868131:MSWAN RS07035
gene id: 868131:MSWAN_RS07035
uniprot id: F6D797
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

868131:MSWAN RS01020
gene id: 868131:MSWAN_RS01020
uniprot id: F6D1M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

868131:MSWAN RS02600
gene id: 868131:MSWAN_RS02600
uniprot id: F6D523
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

868131:MSWAN RS06175
gene id: 868131:MSWAN_RS06175
uniprot id: F6D5S8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

868131:MSWAN RS05100
gene id: 868131:MSWAN_RS05100
uniprot id: F6D3P9
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

868131:MSWAN RS02225
gene id: 868131:MSWAN_RS02225
uniprot id: F6D462
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

868131:MSWAN RS11735
gene id: 868131:MSWAN_RS11735
uniprot id: F6D600
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

868131:MSWAN RS02330
gene id: 868131:MSWAN_RS02330
uniprot id: F6D4L9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

868131:MSWAN RS04225
gene id: 868131:MSWAN_RS04225
uniprot id: F6D1R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane
messages: Membrane

868131:MSWAN RS00655
gene id: 868131:MSWAN_RS00655
uniprot id: F6D834
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS07295
gene id: 868131:MSWAN_RS07295
uniprot id: F6D7L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

868131:MSWAN RS04410
gene id: 868131:MSWAN_RS04410
uniprot id: F6D241
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS05485
gene id: 868131:MSWAN_RS05485
uniprot id: F6D4B9
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS01795
gene id: 868131:MSWAN_RS01795
uniprot id: F6D338
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

868131:MSWAN RS09080
gene id: 868131:MSWAN_RS09080
uniprot id: F6D5B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

868131:MSWAN RS08780
gene id: 868131:MSWAN_RS08780
uniprot id: F6D3Y8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

868131:MSWAN RS05620
gene id: 868131:MSWAN_RS05620
uniprot id: F6D4T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

868131:MSWAN RS09220
gene id: 868131:MSWAN_RS09220
uniprot id: F6D5D9
names: Similarity
messages: Belongs to the thymidylate kinase family.

868131:MSWAN RS08895
gene id: 868131:MSWAN_RS08895
uniprot id: F6D4E9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

868131:MSWAN RS03390
gene id: 868131:MSWAN_RS03390
uniprot id: F6D6K1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

868131:MSWAN RS07580
gene id: 868131:MSWAN_RS07580
uniprot id: F6D8A6
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS10855
gene id: 868131:MSWAN_RS10855
uniprot id: F6D422
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS07620
gene id: 868131:MSWAN_RS07620
uniprot id: F6D8B5
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS09215
gene id: 868131:MSWAN_RS09215
uniprot id: F6D5D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

868131:MSWAN RS02220
gene id: 868131:MSWAN_RS02220
uniprot id: F6D461
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

868131:MSWAN RS05370
gene id: 868131:MSWAN_RS05370
uniprot id: F6D496
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

868131:MSWAN RS08550
gene id: 868131:MSWAN_RS08550
uniprot id: F6D3U0
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

868131:MSWAN RS02970
gene id: 868131:MSWAN_RS02970
uniprot id: F6D5L4
names: Similarity
messages: Belongs to the TrpF family.

868131:MSWAN RS02210
gene id: 868131:MSWAN_RS02210
uniprot id: F6D459
names: Similarity
messages: Belongs to the DEAD box helicase family.

868131:MSWAN RS07520
gene id: 868131:MSWAN_RS07520
uniprot id: F6D805
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS09750
gene id: 868131:MSWAN_RS09750
uniprot id: F6D6U3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

868131:MSWAN RS03650
gene id: 868131:MSWAN_RS03650
uniprot id: F6D7I0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

868131:MSWAN RS08655
gene id: 868131:MSWAN_RS08655
uniprot id: F6D3W2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

868131:MSWAN RS02200
gene id: 868131:MSWAN_RS02200
uniprot id: F6D457
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

868131:MSWAN RS02070
gene id: 868131:MSWAN_RS02070
uniprot id: F6D3N9
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

868131:MSWAN RS06125
gene id: 868131:MSWAN_RS06125
uniprot id: F6D5R8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

868131:MSWAN RS03155
gene id: 868131:MSWAN_RS03155
uniprot id: F6D618
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS03460
gene id: 868131:MSWAN_RS03460
uniprot id: F6D6L3
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

868131:MSWAN RS09020
gene id: 868131:MSWAN_RS09020
uniprot id: F6D4W8
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

868131:MSWAN RS07750
gene id: 868131:MSWAN_RS07750
uniprot id: F6D1U8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

868131:MSWAN RS04740
gene id: 868131:MSWAN_RS04740
uniprot id: F6D2N9
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS03780
gene id: 868131:MSWAN_RS03780
uniprot id: F6D7U6
names: Similarity
messages: Belongs to the DtxR/MntR family.

868131:MSWAN RS01250
gene id: 868131:MSWAN_RS01250
uniprot id: F6D203
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS08565
gene id: 868131:MSWAN_RS08565
uniprot id: F6D3U4
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS00410
gene id: 868131:MSWAN_RS00410
uniprot id: F6D7Q0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS03440
gene id: 868131:MSWAN_RS03440
uniprot id: F6D6K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

868131:MSWAN RS01190
gene id: 868131:MSWAN_RS01190
uniprot id: F6D1Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

868131:MSWAN RS09930
gene id: 868131:MSWAN_RS09930
uniprot id: F6D758
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

868131:MSWAN RS01955
gene id: 868131:MSWAN_RS01955
uniprot id: F6D3L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

868131:MSWAN RS04980
gene id: 868131:MSWAN_RS04980
uniprot id: F6D381
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

868131:MSWAN RS11815
gene id: 868131:MSWAN_RS11815
uniprot id: F6D6F2
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS10000
gene id: 868131:MSWAN_RS10000
uniprot id: F6D1V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

868131:MSWAN RS07290
gene id: 868131:MSWAN_RS07290
uniprot id: F6D7L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

868131:MSWAN RS08650
gene id: 868131:MSWAN_RS08650
uniprot id: F6D3W1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

868131:MSWAN RS00805
gene id: 868131:MSWAN_RS00805
uniprot id: F6D865
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

868131:MSWAN RS05630
gene id: 868131:MSWAN_RS05630
uniprot id: F6D4T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

868131:MSWAN RS06495
gene id: 868131:MSWAN_RS06495
uniprot id: F6D6P1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS01615
gene id: 868131:MSWAN_RS01615
uniprot id: F6D302
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS01680
gene id: 868131:MSWAN_RS01680
uniprot id: F6D315
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

868131:MSWAN RS01650
gene id: 868131:MSWAN_RS01650
uniprot id: F6D309
names: Similarity
messages: Belongs to the UPF0292 family.

868131:MSWAN RS00275
gene id: 868131:MSWAN_RS00275
uniprot id: F6D7M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

868131:MSWAN RS03445
gene id: 868131:MSWAN_RS03445
uniprot id: F6D6L0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

868131:MSWAN RS11950
gene id: 868131:MSWAN_RS11950
uniprot id: F6D6H7
names: Subunit
messages: Homotetramer.

868131:MSWAN RS00985
gene id: 868131:MSWAN_RS00985
uniprot id: F6D1L7
names: Similarity
messages: Belongs to the AAA ATPase family.

868131:MSWAN RS00525
gene id: 868131:MSWAN_RS00525
uniprot id: F6D7S4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS02605
gene id: 868131:MSWAN_RS02605
uniprot id: F6D524
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

868131:MSWAN RS00965
gene id: 868131:MSWAN_RS00965
uniprot id: F6D1L3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

868131:MSWAN RS03820
gene id: 868131:MSWAN_RS03820
uniprot id: F6D7V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

868131:MSWAN RS09115
gene id: 868131:MSWAN_RS09115
uniprot id: F6D5B8
names: Similarity
messages: Belongs to the PDCD5 family.

868131:MSWAN RS08635
gene id: 868131:MSWAN_RS08635
uniprot id: F6D3V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

868131:MSWAN RS02065
gene id: 868131:MSWAN_RS02065
uniprot id: F6D3N8
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS04355
gene id: 868131:MSWAN_RS04355
uniprot id: F6D231
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

868131:MSWAN RS07825
gene id: 868131:MSWAN_RS07825
uniprot id: F6D273
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS02550
gene id: 868131:MSWAN_RS02550
uniprot id: F6D4R3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

868131:MSWAN RS10790
gene id: 868131:MSWAN_RS10790
uniprot id: F6D409
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

868131:MSWAN RS08390
gene id: 868131:MSWAN_RS08390
uniprot id: F6D3B8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

868131:MSWAN RS05140
gene id: 868131:MSWAN_RS05140
uniprot id: F6D3Q7
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

868131:MSWAN RS05860
gene id: 868131:MSWAN_RS05860
uniprot id: F6D585
names: Function
messages: Part of a potassium transport system.

868131:MSWAN RS09440
gene id: 868131:MSWAN_RS09440
uniprot id: F6D6A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

868131:MSWAN RS00205
gene id: 868131:MSWAN_RS00205
uniprot id: F6D7E7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

868131:MSWAN RS04790
gene id: 868131:MSWAN_RS04790
uniprot id: F6D2P9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

868131:MSWAN RS10140
gene id: 868131:MSWAN_RS10140
uniprot id: F6D2C8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

868131:MSWAN RS09975
gene id: 868131:MSWAN_RS09975
uniprot id: F6D767
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

868131:MSWAN RS12080
gene id: 868131:MSWAN_RS12080
uniprot id: F6D6X9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS02530
gene id: 868131:MSWAN_RS02530
uniprot id: F6D4Q8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

868131:MSWAN RS10495
gene id: 868131:MSWAN_RS10495
uniprot id: F6D3E9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS02800
gene id: 868131:MSWAN_RS02800
uniprot id: F6D563
names: Similarity
messages: Belongs to the HerA family.

868131:MSWAN RS11340
gene id: 868131:MSWAN_RS11340
uniprot id: F6D512
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

868131:MSWAN RS00405
gene id: 868131:MSWAN_RS00405
uniprot id: F6D7P9
names: Similarity
messages: Belongs to the CutA family.

868131:MSWAN RS07950
gene id: 868131:MSWAN_RS07950
uniprot id: F6D298
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

868131:MSWAN RS01525
gene id: 868131:MSWAN_RS01525
uniprot id: F6D2I9
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS09615
gene id: 868131:MSWAN_RS09615
uniprot id: F6D6D3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

868131:MSWAN RS10015
gene id: 868131:MSWAN_RS10015
uniprot id: F6D1W2
names: Similarity
messages: Belongs to the UPRTase family.

868131:MSWAN RS06325
gene id: 868131:MSWAN_RS06325
uniprot id: F6D677
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS06445
gene id: 868131:MSWAN_RS06445
uniprot id: F6D6N1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

868131:MSWAN RS00850
gene id: 868131:MSWAN_RS00850
uniprot id: F6D1J0
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

868131:MSWAN RS00130
gene id: 868131:MSWAN_RS00130
uniprot id: F6D7D1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

868131:MSWAN RS05615
gene id: 868131:MSWAN_RS05615
uniprot id: F6D4T4
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS06280
gene id: 868131:MSWAN_RS06280
uniprot id: F6D668
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

868131:MSWAN RS03700
gene id: 868131:MSWAN_RS03700
uniprot id: F6D7T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

868131:MSWAN RS04555
gene id: 868131:MSWAN_RS04555
uniprot id: F6D2K2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

868131:MSWAN RS01045
gene id: 868131:MSWAN_RS01045
uniprot id: F6D1M9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

868131:MSWAN RS10150
gene id: 868131:MSWAN_RS10150
uniprot id: F6D2D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

868131:MSWAN RS01125
gene id: 868131:MSWAN_RS01125
uniprot id: F6D1Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

868131:MSWAN RS02965
gene id: 868131:MSWAN_RS02965
uniprot id: F6D5L3
names: Similarity
messages: Belongs to the TrpC family.

868131:MSWAN RS11935
gene id: 868131:MSWAN_RS11935
uniprot id: F6D6H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

868131:MSWAN RS11425
gene id: 868131:MSWAN_RS11425
uniprot id: F6D5F7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

868131:MSWAN RS09345
gene id: 868131:MSWAN_RS09345
uniprot id: F6D5V0
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

868131:MSWAN RS10385
gene id: 868131:MSWAN_RS10385
uniprot id: F6D2X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

868131:MSWAN RS07195
gene id: 868131:MSWAN_RS07195
uniprot id: F6D7J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

868131:MSWAN RS00695
gene id: 868131:MSWAN_RS00695
uniprot id: F6D842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

868131:MSWAN RS02845
gene id: 868131:MSWAN_RS02845
uniprot id: F6D5J0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

868131:MSWAN RS06675
gene id: 868131:MSWAN_RS06675
uniprot id: F6D6Z2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

868131:MSWAN RS09290
gene id: 868131:MSWAN_RS09290
uniprot id: F6D5U2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

868131:MSWAN RS10250
gene id: 868131:MSWAN_RS10250
uniprot id: F6D2E9
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

868131:MSWAN RS11665
gene id: 868131:MSWAN_RS11665
uniprot id: F6D5Y7
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

868131:MSWAN RS02375
gene id: 868131:MSWAN_RS02375
uniprot id: F6D4M8
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

868131:MSWAN RS09780
gene id: 868131:MSWAN_RS09780
uniprot id: F6D6U9
names: Similarity
messages: Belongs to the UPF0216 family.

868131:MSWAN RS03510
gene id: 868131:MSWAN_RS03510
uniprot id: F6D6M2
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

868131:MSWAN RS00080
gene id: 868131:MSWAN_RS00080
uniprot id: F6D7C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

868131:MSWAN RS01030
gene id: 868131:MSWAN_RS01030
uniprot id: F6D1M6
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

868131:MSWAN RS11995
gene id: 868131:MSWAN_RS11995
uniprot id: F6D6I6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

868131:MSWAN RS02310
gene id: 868131:MSWAN_RS02310
uniprot id: F6D478
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

868131:MSWAN RS10475
gene id: 868131:MSWAN_RS10475
uniprot id: F6D2Z2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

868131:MSWAN RS10035
gene id: 868131:MSWAN_RS10035
uniprot id: F6D1W6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

868131:MSWAN RS12005
gene id: 868131:MSWAN_RS12005
uniprot id: F6D6W6
names: Similarity
messages: Belongs to the UPF0284 family.

868131:MSWAN RS11930
gene id: 868131:MSWAN_RS11930
uniprot id: F6D6H3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

868131:MSWAN RS00565
gene id: 868131:MSWAN_RS00565
uniprot id: F6D816
names: Similarity
messages: Belongs to the MvhD/VhuD family.

868131:MSWAN RS06440
gene id: 868131:MSWAN_RS06440
uniprot id: F6D6N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

868131:MSWAN RS11805
gene id: 868131:MSWAN_RS11805
uniprot id: F6D6F0
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS03690
gene id: 868131:MSWAN_RS03690
uniprot id: F6D7T2
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

868131:MSWAN RS08660
gene id: 868131:MSWAN_RS08660
uniprot id: F6D3W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

868131:MSWAN RS07120
gene id: 868131:MSWAN_RS07120
uniprot id: F6D7I1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

868131:MSWAN RS08395
gene id: 868131:MSWAN_RS08395
uniprot id: F6D3B9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

868131:MSWAN RS05835
gene id: 868131:MSWAN_RS05835
uniprot id: F6D579
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS01200
gene id: 868131:MSWAN_RS01200
uniprot id: F6D1Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

868131:MSWAN RS02345
gene id: 868131:MSWAN_RS02345
uniprot id: F6D4M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

868131:MSWAN RS06640
gene id: 868131:MSWAN_RS06640
uniprot id: F6D6R8
names: Subcellular Location Annotation
messages: Membrane

868131:MSWAN RS09225
gene id: 868131:MSWAN_RS09225
uniprot id: F6D5E0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

868131:MSWAN RS05805
gene id: 868131:MSWAN_RS05805
uniprot id: F6D574
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

868131:MSWAN RS09025
gene id: 868131:MSWAN_RS09025
uniprot id: F6D4W9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

868131:MSWAN RS00225
gene id: 868131:MSWAN_RS00225
uniprot id: F6D7F1
names: Similarity
messages: Belongs to the intimin/invasin family.