86660:MDIS RS00275
gene id: 86660:MDIS_RS00275
uniprot id: A0A0C5WWV7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

86660:MDIS RS00865
gene id: 86660:MDIS_RS00865
uniprot id: A0A2D1UD12
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

86660:MDIS RS04400
gene id: 86660:MDIS_RS04400
uniprot id: A0A0C5WWJ1
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

86660:MDIS RS03715
gene id: 86660:MDIS_RS03715
uniprot id: A0A0C5WI66
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS00315
gene id: 86660:MDIS_RS00315
uniprot id: A0A0C5X6C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

86660:MDIS RS00245
gene id: 86660:MDIS_RS00245
uniprot id: A0A0C5WGK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

86660:MDIS RS02695
gene id: 86660:MDIS_RS02695
uniprot id: A0A0C5WXR9
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

86660:MDIS RS02140
gene id: 86660:MDIS_RS02140
uniprot id: A0A0C5WVM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

86660:MDIS RS01530
gene id: 86660:MDIS_RS01530
uniprot id: A0A0C5WXB9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

86660:MDIS RS01610
gene id: 86660:MDIS_RS01610
uniprot id: A0A0C5WVE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

86660:MDIS RS02860
gene id: 86660:MDIS_RS02860
uniprot id: A0A0C5WVU6
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS01490
gene id: 86660:MDIS_RS01490
uniprot id: A0A0C5X6Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

86660:MDIS RS00455
gene id: 86660:MDIS_RS00455
uniprot id: A0A0C5X150
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

86660:MDIS RS02365
gene id: 86660:MDIS_RS02365
uniprot id: A0A0C5WVQ1
names: Caution
names: Similarity
messages: Belongs to the peptidase S8 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS01505
gene id: 86660:MDIS_RS01505
uniprot id: A0A0C5WVC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

86660:MDIS RS02630
gene id: 86660:MDIS_RS02630
uniprot id: A0A0C5X205
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

86660:MDIS RS00005
gene id: 86660:MDIS_RS00005
uniprot id: A0A0C5WWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

86660:MDIS RS02335
gene id: 86660:MDIS_RS02335
uniprot id: A0A0C5WHN0
names: Similarity
messages: Belongs to the transketolase family.

86660:MDIS RS00790
gene id: 86660:MDIS_RS00790
uniprot id: A0A0C5X6J7
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS04290
gene id: 86660:MDIS_RS04290
uniprot id: A0A0C5WX01
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

86660:MDIS RS03760
gene id: 86660:MDIS_RS03760
uniprot id: A0A0C5X2H7
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS01980
gene id: 86660:MDIS_RS01980
uniprot id: A0A0C5X773
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

86660:MDIS RS02770
gene id: 86660:MDIS_RS02770
uniprot id: A0A0C5WXS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

86660:MDIS RS00690
gene id: 86660:MDIS_RS00690
uniprot id: A0A0C5WUW7
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

86660:MDIS RS01550
gene id: 86660:MDIS_RS01550
uniprot id: A0A0C5WHA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

86660:MDIS RS01525
gene id: 86660:MDIS_RS01525
uniprot id: A0A0C5WHA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

86660:MDIS RS01585
gene id: 86660:MDIS_RS01585
uniprot id: A0A0C5WVE3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

86660:MDIS RS02040
gene id: 86660:MDIS_RS02040
uniprot id: A0A0C5X778
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

86660:MDIS RS02655
gene id: 86660:MDIS_RS02655
uniprot id: A0A0C5X211
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

86660:MDIS RS00970
gene id: 86660:MDIS_RS00970
uniprot id: A0A0C5X6N7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

86660:MDIS RS04395
gene id: 86660:MDIS_RS04395
uniprot id: A0A0C5WYD0
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

86660:MDIS RS03350
gene id: 86660:MDIS_RS03350
uniprot id: A0A0C5WHX7
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS00055
gene id: 86660:MDIS_RS00055
uniprot id: A0A0C5WWS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

86660:MDIS RS01555
gene id: 86660:MDIS_RS01555
uniprot id: A0A0C5WXC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

86660:MDIS RS02215
gene id: 86660:MDIS_RS02215
uniprot id: A0A0C5WVN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

86660:MDIS RS01015
gene id: 86660:MDIS_RS01015
uniprot id: A0A0C5WX48
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

86660:MDIS RS01750
gene id: 86660:MDIS_RS01750
uniprot id: A0A0C5X731
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

86660:MDIS RS03905
gene id: 86660:MDIS_RS03905
uniprot id: A0A0C5WWB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

86660:MDIS RS00835
gene id: 86660:MDIS_RS00835
uniprot id: A0A0C5WGX7
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS00260
gene id: 86660:MDIS_RS00260
uniprot id: A0A0C5X123
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

86660:MDIS RS03200
gene id: 86660:MDIS_RS03200
uniprot id: A0A0C5X7H9
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS01780
gene id: 86660:MDIS_RS01780
uniprot id: A0A0C5X1P7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

86660:MDIS RS00070
gene id: 86660:MDIS_RS00070
uniprot id: A0A0C5X680
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

86660:MDIS RS01690
gene id: 86660:MDIS_RS01690
uniprot id: A0A0C5WXD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

86660:MDIS RS02990
gene id: 86660:MDIS_RS02990
uniprot id: A0A0C5WVV8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

86660:MDIS RS00755
gene id: 86660:MDIS_RS00755
uniprot id: A0A0C5WUX8
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

86660:MDIS RS00155
gene id: 86660:MDIS_RS00155
uniprot id: A0A0C5WGJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

86660:MDIS RS03380
gene id: 86660:MDIS_RS03380
uniprot id: A0A0C5WY00
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

86660:MDIS RS01600
gene id: 86660:MDIS_RS01600
uniprot id: A0A0C5WHB7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

86660:MDIS RS02760
gene id: 86660:MDIS_RS02760
uniprot id: A0A0C5X7D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

86660:MDIS RS01350
gene id: 86660:MDIS_RS01350
uniprot id: A0A0C5X6V8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

86660:MDIS RS00570
gene id: 86660:MDIS_RS00570
uniprot id: A0A0C5WGS5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

86660:MDIS RS00640
gene id: 86660:MDIS_RS00640
uniprot id: A0A0C5X6H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

86660:MDIS RS02895
gene id: 86660:MDIS_RS02895
uniprot id: A0A0C5WVV1
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

86660:MDIS RS01270
gene id: 86660:MDIS_RS01270
uniprot id: A0A0C5WH64
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

86660:MDIS RS00205
gene id: 86660:MDIS_RS00205
uniprot id: A0A0C5X115
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

86660:MDIS RS03190
gene id: 86660:MDIS_RS03190
uniprot id: A0A0C5WVY3
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

86660:MDIS RS01135
gene id: 86660:MDIS_RS01135
uniprot id: A0A0C5WH34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

86660:MDIS RS00305
gene id: 86660:MDIS_RS00305
uniprot id: A0A0C5WUP1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

86660:MDIS RS00945
gene id: 86660:MDIS_RS00945
uniprot id: A0A0C5WH02
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS01680
gene id: 86660:MDIS_RS01680
uniprot id: A0A0C5X720
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

86660:MDIS RS01140
gene id: 86660:MDIS_RS01140
uniprot id: A0A0C5WX65
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

86660:MDIS RS00470
gene id: 86660:MDIS_RS00470
uniprot id: A0A0C5WWY2
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS00135
gene id: 86660:MDIS_RS00135
uniprot id: A0A0C5WWT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

86660:MDIS RS02880
gene id: 86660:MDIS_RS02880
uniprot id: A0A0C5WHS6
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS01815
gene id: 86660:MDIS_RS01815
uniprot id: A0A0C5WHF1
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS01880
gene id: 86660:MDIS_RS01880
uniprot id: A0A0C5X753
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

86660:MDIS RS00735
gene id: 86660:MDIS_RS00735
uniprot id: A0A0C5X187
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

86660:MDIS RS00175
gene id: 86660:MDIS_RS00175
uniprot id: A0A0C5X696
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

86660:MDIS RS02810
gene id: 86660:MDIS_RS02810
uniprot id: A0A0C5X7E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

86660:MDIS RS01285
gene id: 86660:MDIS_RS01285
uniprot id: A0A0C5X1H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

86660:MDIS RS03790
gene id: 86660:MDIS_RS03790
uniprot id: A0A0C5X7P3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

86660:MDIS RS03015
gene id: 86660:MDIS_RS03015
uniprot id: A0A0C5WVW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

86660:MDIS RS00020
gene id: 86660:MDIS_RS00020
uniprot id: A0A0C5X671
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

86660:MDIS RS03620
gene id: 86660:MDIS_RS03620
uniprot id: A0A0C5X2F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

86660:MDIS RS03345
gene id: 86660:MDIS_RS03345
uniprot id: A0A0C5X7J5
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

86660:MDIS RS00900
gene id: 86660:MDIS_RS00900
uniprot id: A0A0C5WX31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

86660:MDIS RS00250
gene id: 86660:MDIS_RS00250
uniprot id: A0A0C5WWV4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

86660:MDIS RS01605
gene id: 86660:MDIS_RS01605
uniprot id: A0A0C5WXC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

86660:MDIS RS00415
gene id: 86660:MDIS_RS00415
uniprot id: A0A0C5WWB6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas9 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.
messages: Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Binds crRNA and tracrRNA.

86660:MDIS RS00585
gene id: 86660:MDIS_RS00585
uniprot id: A0A0C5X166
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

86660:MDIS RS02540
gene id: 86660:MDIS_RS02540
uniprot id: A0A0C5WXQ2
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS03610
gene id: 86660:MDIS_RS03610
uniprot id: A0A2D1UED4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

86660:MDIS RS00015
gene id: 86660:MDIS_RS00015
uniprot id: A0A0C5X0Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

86660:MDIS RS00390
gene id: 86660:MDIS_RS00390
uniprot id: A0A0C5X142
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

86660:MDIS RS02700
gene id: 86660:MDIS_RS02700
uniprot id: A0A0C5WVT1
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

86660:MDIS RS02620
gene id: 86660:MDIS_RS02620
uniprot id: A0A0C5WXQ5
names: Cofactor
messages: Binds 1 zinc ion per subunit.

86660:MDIS RS00280
gene id: 86660:MDIS_RS00280
uniprot id: A0A0C5WUN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

86660:MDIS RS00210
gene id: 86660:MDIS_RS00210
uniprot id: A0A0C5X6A0
names: Function
names: Similarity
messages: Belongs to the ATPase gamma chain family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

86660:MDIS RS00895
gene id: 86660:MDIS_RS00895
uniprot id: A0A0C5WGY9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

86660:MDIS RS01265
gene id: 86660:MDIS_RS01265
uniprot id: A0A0C5X6U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

86660:MDIS RS03040
gene id: 86660:MDIS_RS03040
uniprot id: A0A0C5WXV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

86660:MDIS RS01520
gene id: 86660:MDIS_RS01520
uniprot id: A0A2D1UDG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

86660:MDIS RS00870
gene id: 86660:MDIS_RS00870
uniprot id: A0A0C5WGY3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

86660:MDIS RS00215
gene id: 86660:MDIS_RS00215
uniprot id: A0A0C5WGK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

86660:MDIS RS02005
gene id: 86660:MDIS_RS02005
uniprot id: A0A0C5WVL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

86660:MDIS RS02640
gene id: 86660:MDIS_RS02640
uniprot id: A0A0C5WHP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

86660:MDIS RS00100
gene id: 86660:MDIS_RS00100
uniprot id: A0A0C5WGI0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

86660:MDIS RS00105
gene id: 86660:MDIS_RS00105
uniprot id: A0A0C5WWT3
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

86660:MDIS RS00730
gene id: 86660:MDIS_RS00730
uniprot id: A0A0C5WUX2
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS03705
gene id: 86660:MDIS_RS03705
uniprot id: A0A0C5X2G7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

86660:MDIS RS01810
gene id: 86660:MDIS_RS01810
uniprot id: A0A0C5X742
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.

86660:MDIS RS00380
gene id: 86660:MDIS_RS00380
uniprot id: A0A0C5WWX1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

86660:MDIS RS03900
gene id: 86660:MDIS_RS03900
uniprot id: A0A0C5WY73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Cell membrane
messages: Membrane

86660:MDIS RS00745
gene id: 86660:MDIS_RS00745
uniprot id: A0A0C5WGW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

86660:MDIS RS01620
gene id: 86660:MDIS_RS01620
uniprot id: A0A0C5X715
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

86660:MDIS RS00980
gene id: 86660:MDIS_RS00980
uniprot id: A0A0C5X2V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

86660:MDIS RS01785
gene id: 86660:MDIS_RS01785
uniprot id: A0A0C5X738
names: Similarity
messages: Belongs to the IMPACT family.

86660:MDIS RS03335
gene id: 86660:MDIS_RS03335
uniprot id: A0A0C5WW07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

86660:MDIS RS00590
gene id: 86660:MDIS_RS00590
uniprot id: A0A0C5X6G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

86660:MDIS RS00195
gene id: 86660:MDIS_RS00195
uniprot id: A0A0C5WWU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

86660:MDIS RS03395
gene id: 86660:MDIS_RS03395
uniprot id: A0A0C5X7K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

86660:MDIS RS00395
gene id: 86660:MDIS_RS00395
uniprot id: A0A0C5X6D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

86660:MDIS RS01000
gene id: 86660:MDIS_RS01000
uniprot id: A0A0C5X1C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

86660:MDIS RS00230
gene id: 86660:MDIS_RS00230
uniprot id: A0A0C5X120
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

86660:MDIS RS00040
gene id: 86660:MDIS_RS00040
uniprot id: A0A0C5X0Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

86660:MDIS RS01840
gene id: 86660:MDIS_RS01840
uniprot id: A0A0C5WYA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

86660:MDIS RS03285
gene id: 86660:MDIS_RS03285
uniprot id: A0A0C5X2A6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS03050
gene id: 86660:MDIS_RS03050
uniprot id: A0A0C5X271
names: Function
messages: Part of a high-affinity transport system.

86660:MDIS RS00050
gene id: 86660:MDIS_RS00050
uniprot id: A0A0C5WGH1
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

86660:MDIS RS02255
gene id: 86660:MDIS_RS02255
uniprot id: A0A0C5WHM2
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS01565
gene id: 86660:MDIS_RS01565
uniprot id: A0A0C5X1L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

86660:MDIS RS00335
gene id: 86660:MDIS_RS00335
uniprot id: A0A0C5X134
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

86660:MDIS RS01805
gene id: 86660:MDIS_RS01805
uniprot id: A0A0C5X1Q1
names: Similarity
messages: Belongs to the MG185/MG260 family.

86660:MDIS RS03695
gene id: 86660:MDIS_RS03695
uniprot id: A0A0C5WY44
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS00635
gene id: 86660:MDIS_RS00635
uniprot id: A0A0C5X175
names: Similarity
messages: Belongs to the DprA/Smf family.

86660:MDIS RS01590
gene id: 86660:MDIS_RS01590
uniprot id: A0A0C5X1M1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

86660:MDIS RS01560
gene id: 86660:MDIS_RS01560
uniprot id: A0A0C5WVD7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

86660:MDIS RS02800
gene id: 86660:MDIS_RS02800
uniprot id: A0A0C5WVU1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

86660:MDIS RS00115
gene id: 86660:MDIS_RS00115
uniprot id: A0A0C5X104
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

86660:MDIS RS00665
gene id: 86660:MDIS_RS00665
uniprot id: A0A0C5X6H6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

86660:MDIS RS02430
gene id: 86660:MDIS_RS02430
uniprot id: A0A0C5X7A6
names: Similarity
messages: Belongs to the peptidase S8 family.

86660:MDIS RS01410
gene id: 86660:MDIS_RS01410
uniprot id: A0A0C5WID8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

86660:MDIS RS03660
gene id: 86660:MDIS_RS03660
uniprot id: A0A0C5WY40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

86660:MDIS RS01405
gene id: 86660:MDIS_RS01405
uniprot id: A0A0C5X6X1
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

86660:MDIS RS00875
gene id: 86660:MDIS_RS00875
uniprot id: A0A0C5WX27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

86660:MDIS RS02180
gene id: 86660:MDIS_RS02180
uniprot id: A0A0C5WHL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

86660:MDIS RS00190
gene id: 86660:MDIS_RS00190
uniprot id: A0A0C5WGJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

86660:MDIS RS03510
gene id: 86660:MDIS_RS03510
uniprot id: A0A0C5X2D7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

86660:MDIS RS02165
gene id: 86660:MDIS_RS02165
uniprot id: A0A0C5WVN1
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

86660:MDIS RS02320
gene id: 86660:MDIS_RS02320
uniprot id: A0A0C5WVP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS04020
gene id: 86660:MDIS_RS04020
uniprot id: A0A0C5WYF7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

86660:MDIS RS00060
gene id: 86660:MDIS_RS00060
uniprot id: A0A0C5WUK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

86660:MDIS RS00010
gene id: 86660:MDIS_RS00010
uniprot id: A0A0C5WUK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

86660:MDIS RS03615
gene id: 86660:MDIS_RS03615
uniprot id: A0A0C5WW53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

86660:MDIS RS02520
gene id: 86660:MDIS_RS02520
uniprot id: A0A0C5WVR3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

86660:MDIS RS03090
gene id: 86660:MDIS_RS03090
uniprot id: A0A0C5WHU7
names: Similarity
messages: Belongs to the MG185/MG260 family.

86660:MDIS RS01400
gene id: 86660:MDIS_RS01400
uniprot id: A0A0C5X1J0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS03910
gene id: 86660:MDIS_RS03910
uniprot id: A0A0C5X2K0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

86660:MDIS RS02740
gene id: 86660:MDIS_RS02740
uniprot id: A0A0C5WHQ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

86660:MDIS RS01120
gene id: 86660:MDIS_RS01120
uniprot id: A0A0C5WV52
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

86660:MDIS RS00565
gene id: 86660:MDIS_RS00565
uniprot id: A0A0C5X6F7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

86660:MDIS RS00750
gene id: 86660:MDIS_RS00750
uniprot id: A0A0C5WX12
names: Similarity
messages: Belongs to the LacAB/RpiB family.

86660:MDIS RS01725
gene id: 86660:MDIS_RS01725
uniprot id: A0A0C5X726
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Cytoplasm
messages: Homotetramer.

86660:MDIS RS03665
gene id: 86660:MDIS_RS03665
uniprot id: A0A0C5WW60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

86660:MDIS RS00325
gene id: 86660:MDIS_RS00325
uniprot id: A0A0C5WWW4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

86660:MDIS RS00270
gene id: 86660:MDIS_RS00270
uniprot id: A0A0C5WGL3
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

86660:MDIS RS03020
gene id: 86660:MDIS_RS03020
uniprot id: A0A0C5X267
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS00605
gene id: 86660:MDIS_RS00605
uniprot id: A0A0C5WUV0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

86660:MDIS RS00960
gene id: 86660:MDIS_RS00960
uniprot id: A0A0C5WV19
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

86660:MDIS RS00125
gene id: 86660:MDIS_RS00125
uniprot id: A0A0C5X688
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

86660:MDIS RS02260
gene id: 86660:MDIS_RS02260
uniprot id: A0A0C5WXM4
names: Similarity
messages: Belongs to the peptidase M17 family.

86660:MDIS RS00680
gene id: 86660:MDIS_RS00680
uniprot id: A0A0C5WGU9
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

86660:MDIS RS00860
gene id: 86660:MDIS_RS00860
uniprot id: A0A0C5X1A3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

86660:MDIS RS02100
gene id: 86660:MDIS_RS02100
uniprot id: A0A0C5WXK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

86660:MDIS RS01615
gene id: 86660:MDIS_RS01615
uniprot id: A0A0C5X1M6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

86660:MDIS RS00310
gene id: 86660:MDIS_RS00310
uniprot id: A0A0C5X130
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

86660:MDIS RS00385
gene id: 86660:MDIS_RS00385
uniprot id: A0A0C5WUQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

86660:MDIS RS02210
gene id: 86660:MDIS_RS02210
uniprot id: A0A0C5WXL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

86660:MDIS RS01210
gene id: 86660:MDIS_RS01210
uniprot id: A0A0C5WH52
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

86660:MDIS RS03310
gene id: 86660:MDIS_RS03310
uniprot id: A0A0C5WW01
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS01495
gene id: 86660:MDIS_RS01495
uniprot id: A0A0C5WH95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

86660:MDIS RS01185
gene id: 86660:MDIS_RS01185
uniprot id: A0A0C5WH45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

86660:MDIS RS02120
gene id: 86660:MDIS_RS02120
uniprot id: A0A0C5X1V7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

86660:MDIS RS00725
gene id: 86660:MDIS_RS00725
uniprot id: A0A0C5WX07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS02000
gene id: 86660:MDIS_RS02000
uniprot id: A0A0C5WXJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

86660:MDIS RS01390
gene id: 86660:MDIS_RS01390
uniprot id: A0A0C5WXA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

86660:MDIS RS01230
gene id: 86660:MDIS_RS01230
uniprot id: A0A0C5X6T9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

86660:MDIS RS01580
gene id: 86660:MDIS_RS01580
uniprot id: A0A0C5WXC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

86660:MDIS RS01215
gene id: 86660:MDIS_RS01215
uniprot id: A0A0C5WX79
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS02025
gene id: 86660:MDIS_RS02025
uniprot id: A0A0C5WXK1
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

86660:MDIS RS02145
gene id: 86660:MDIS_RS02145
uniprot id: A0A0C5X1W0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S16 family.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

86660:MDIS RS02220
gene id: 86660:MDIS_RS02220
uniprot id: A0A0C5X1W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

86660:MDIS RS01430
gene id: 86660:MDIS_RS01430
uniprot id: A0A0C5WVB4
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS03605
gene id: 86660:MDIS_RS03605
uniprot id: A0A0C5WY32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

86660:MDIS RS03670
gene id: 86660:MDIS_RS03670
uniprot id: A0A0C5X2G3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

86660:MDIS RS01500
gene id: 86660:MDIS_RS01500
uniprot id: A0A0C5WXB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

86660:MDIS RS01760
gene id: 86660:MDIS_RS01760
uniprot id: A0A0C5WXE6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

86660:MDIS RS00410
gene id: 86660:MDIS_RS00410
uniprot id: A0A0C5WWX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

86660:MDIS RS02835
gene id: 86660:MDIS_RS02835
uniprot id: A0A0C5WVU3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

86660:MDIS RS01545
gene id: 86660:MDIS_RS01545
uniprot id: A0A0C5X6Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

86660:MDIS RS03645
gene id: 86660:MDIS_RS03645
uniprot id: A0A0C5X2F9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

86660:MDIS RS01320
gene id: 86660:MDIS_RS01320
uniprot id: A0A0C5X1I1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

86660:MDIS RS03650
gene id: 86660:MDIS_RS03650
uniprot id: A0A0C5X7M8
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

86660:MDIS RS03785
gene id: 86660:MDIS_RS03785
uniprot id: A0A0C5X2I2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

86660:MDIS RS01235
gene id: 86660:MDIS_RS01235
uniprot id: A0A0C5WH57
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

86660:MDIS RS03865
gene id: 86660:MDIS_RS03865
uniprot id: A0A0C5X7Q0
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

86660:MDIS RS00910
gene id: 86660:MDIS_RS00910
uniprot id: A0A0C5X1B3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

86660:MDIS RS01115
gene id: 86660:MDIS_RS01115
uniprot id: A0A0C5WX60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

86660:MDIS RS03435
gene id: 86660:MDIS_RS03435
uniprot id: A0A0C5WW28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

86660:MDIS RS01745
gene id: 86660:MDIS_RS01745
uniprot id: A0A0C5X1P2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

86660:MDIS RS01180
gene id: 86660:MDIS_RS01180
uniprot id: A0A0C5X6S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

86660:MDIS RS02910
gene id: 86660:MDIS_RS02910
uniprot id: A0A2D1UE23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

86660:MDIS RS01595
gene id: 86660:MDIS_RS01595
uniprot id: A0A0C5X707
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

86660:MDIS RS01220
gene id: 86660:MDIS_RS01220
uniprot id: A0A0C5WV74
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

86660:MDIS RS03385
gene id: 86660:MDIS_RS03385
uniprot id: A0A0C5WW19
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

86660:MDIS RS03300
gene id: 86660:MDIS_RS03300
uniprot id: A0A0C5WXY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

86660:MDIS RS01260
gene id: 86660:MDIS_RS01260
uniprot id: A0A0C5X1G9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

86660:MDIS RS00535
gene id: 86660:MDIS_RS00535
uniprot id: A0A0C5X159
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

86660:MDIS RS03710
gene id: 86660:MDIS_RS03710
uniprot id: A0A0C5X7N5
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

86660:MDIS RS01945
gene id: 86660:MDIS_RS01945
uniprot id: A0A0C5WXJ0
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS03575
gene id: 86660:MDIS_RS03575
uniprot id: A0A0C5WI29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

86660:MDIS RS03425
gene id: 86660:MDIS_RS03425
uniprot id: A0A0C5WHZ9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

86660:MDIS RS01275
gene id: 86660:MDIS_RS01275
uniprot id: A0A0C5WX87
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

86660:MDIS RS00200
gene id: 86660:MDIS_RS00200
uniprot id: A0A0C5WUM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

86660:MDIS RS00095
gene id: 86660:MDIS_RS00095
uniprot id: A0A0C5X683
names: Similarity
messages: Belongs to the peptidase A8 family.

86660:MDIS RS01735
gene id: 86660:MDIS_RS01735
uniprot id: A0A0C5WXE2
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS01540
gene id: 86660:MDIS_RS01540
uniprot id: A0A0C5X1L1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

86660:MDIS RS02415
gene id: 86660:MDIS_RS02415
uniprot id: A0A0C5WXN7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

86660:MDIS RS03725
gene id: 86660:MDIS_RS03725
uniprot id: A0A0C5WW71
names: Subunit
messages: Monomer.

86660:MDIS RS02105
gene id: 86660:MDIS_RS02105
uniprot id: A0A0C5WVM4
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

86660:MDIS RS01695
gene id: 86660:MDIS_RS01695
uniprot id: A0A0C5WVG0
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

86660:MDIS RS00580
gene id: 86660:MDIS_RS00580
uniprot id: A0A0C5WUU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

86660:MDIS RS00495
gene id: 86660:MDIS_RS00495
uniprot id: A0A0C5WGR1
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS02340
gene id: 86660:MDIS_RS02340
uniprot id: A0A0C5WXN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

86660:MDIS RS01125
gene id: 86660:MDIS_RS01125
uniprot id: A0A0C5X1E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

86660:MDIS RS03365
gene id: 86660:MDIS_RS03365
uniprot id: A0A0C5X2B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

86660:MDIS RS02160
gene id: 86660:MDIS_RS02160
uniprot id: A0A0C5WXL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

86660:MDIS RS03255
gene id: 86660:MDIS_RS03255
uniprot id: A0A0C5WVZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

86660:MDIS RS03600
gene id: 86660:MDIS_RS03600
uniprot id: A0A0C5WI37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

86660:MDIS RS00695
gene id: 86660:MDIS_RS00695
uniprot id: A0A0C5X182
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

86660:MDIS RS00130
gene id: 86660:MDIS_RS00130
uniprot id: A0A0C5WGI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

86660:MDIS RS01485
gene id: 86660:MDIS_RS01485
uniprot id: A0A0C5X1K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

86660:MDIS RS00475
gene id: 86660:MDIS_RS00475
uniprot id: A0A0C5WUT0
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS03260
gene id: 86660:MDIS_RS03260
uniprot id: A0A0C5X2A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

86660:MDIS RS02865
gene id: 86660:MDIS_RS02865
uniprot id: A0A0C5X244
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

86660:MDIS RS00450
gene id: 86660:MDIS_RS00450
uniprot id: A0A0C5WUS3
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS00930
gene id: 86660:MDIS_RS00930
uniprot id: A0A0C5WV13
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

86660:MDIS RS01160
gene id: 86660:MDIS_RS01160
uniprot id: A0A0C5WH39
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS03640
gene id: 86660:MDIS_RS03640
uniprot id: A0A0C5WW57
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS03370
gene id: 86660:MDIS_RS03370
uniprot id: A0A0C5X7J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

86660:MDIS RS02820
gene id: 86660:MDIS_RS02820
uniprot id: A0A0C5WHR6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

86660:MDIS RS03755
gene id: 86660:MDIS_RS03755
uniprot id: A0A0C5WW78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

86660:MDIS RS03230
gene id: 86660:MDIS_RS03230
uniprot id: A0A0C5X295
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS00905
gene id: 86660:MDIS_RS00905
uniprot id: A0A0C5WV05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

86660:MDIS RS01885
gene id: 86660:MDIS_RS01885
uniprot id: A0A0C5WHG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

86660:MDIS RS00940
gene id: 86660:MDIS_RS00940
uniprot id: A0A0C5X6N2
names: Subcellular Location Annotation
messages: Membrane

86660:MDIS RS02935
gene id: 86660:MDIS_RS02935
uniprot id: A0A0C5WVV3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

86660:MDIS RS03220
gene id: 86660:MDIS_RS03220
uniprot id: A0A0C5WXX6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

86660:MDIS RS03080
gene id: 86660:MDIS_RS03080
uniprot id: A0A0C5WWM0
names: Similarity
messages: Belongs to the MG185/MG260 family.

86660:MDIS RS01535
gene id: 86660:MDIS_RS01535
uniprot id: A0A2D1UDT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

86660:MDIS RS01290
gene id: 86660:MDIS_RS01290
uniprot id: A0A0C5X6V1
names: Similarity
messages: Belongs to the CTP synthase family.

86660:MDIS RS00480
gene id: 86660:MDIS_RS00480
uniprot id: A0A0C5X154
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

86660:MDIS RS01415
gene id: 86660:MDIS_RS01415
uniprot id: A0A0C5WH85
names: Similarity
messages: Belongs to the DapA family.

86660:MDIS RS01510
gene id: 86660:MDIS_RS01510
uniprot id: A0A0C5X1K6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

86660:MDIS RS03885
gene id: 86660:MDIS_RS03885
uniprot id: A0A0C5X2J5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.