858215:THEXY RS11180
gene id: 858215:THEXY_RS11180
uniprot id: F6BL86
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

858215:THEXY RS01770
gene id: 858215:THEXY_RS01770
uniprot id: F6BGP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

858215:THEXY RS09595
gene id: 858215:THEXY_RS09595
uniprot id: F6BJ91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

858215:THEXY RS00430
gene id: 858215:THEXY_RS00430
uniprot id: F6BLG1
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

858215:THEXY RS03470
gene id: 858215:THEXY_RS03470
uniprot id: F6BIA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

858215:THEXY RS06125
gene id: 858215:THEXY_RS06125
uniprot id: F6BL41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS04055
gene id: 858215:THEXY_RS04055
uniprot id: F6BIZ2
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

858215:THEXY RS07020
gene id: 858215:THEXY_RS07020
uniprot id: F6BG61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

858215:THEXY RS08220
gene id: 858215:THEXY_RS08220
uniprot id: F6BHP1
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.

858215:THEXY RS06650
gene id: 858215:THEXY_RS06650
uniprot id: F6BFJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

858215:THEXY RS10570
gene id: 858215:THEXY_RS10570
uniprot id: F6BKE9
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

858215:THEXY RS11375
gene id: 858215:THEXY_RS11375
uniprot id: F6BLQ6
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

858215:THEXY RS10080
gene id: 858215:THEXY_RS10080
uniprot id: F6BJY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS05465
gene id: 858215:THEXY_RS05465
uniprot id: F6BK97
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS12025
gene id: 858215:THEXY_RS12025
uniprot id: F6BFS8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

858215:THEXY RS00915
gene id: 858215:THEXY_RS00915
uniprot id: F6BFF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

858215:THEXY RS05265
gene id: 858215:THEXY_RS05265
uniprot id: F6BK59
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS00570
gene id: 858215:THEXY_RS00570
uniprot id: F6BF86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

858215:THEXY RS10190
gene id: 858215:THEXY_RS10190
uniprot id: F6BK05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

858215:THEXY RS02375
gene id: 858215:THEXY_RS02375
uniprot id: F6BH55
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

858215:THEXY RS01895
gene id: 858215:THEXY_RS01895
uniprot id: F6BGR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

858215:THEXY RS05345
gene id: 858215:THEXY_RS05345
uniprot id: F6BK73
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS06945
gene id: 858215:THEXY_RS06945
uniprot id: F6BG46
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

858215:THEXY RS11065
gene id: 858215:THEXY_RS11065
uniprot id: F6BL64
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS07110
gene id: 858215:THEXY_RS07110
uniprot id: F6BG80
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

858215:THEXY RS10335
gene id: 858215:THEXY_RS10335
uniprot id: F6BK33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

858215:THEXY RS05275
gene id: 858215:THEXY_RS05275
uniprot id: F6BK61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

858215:THEXY RS10760
gene id: 858215:THEXY_RS10760
uniprot id: F6BKQ2
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS05305
gene id: 858215:THEXY_RS05305
uniprot id: F6BK67
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

858215:THEXY RS02395
gene id: 858215:THEXY_RS02395
uniprot id: F6BH59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

858215:THEXY RS06195
gene id: 858215:THEXY_RS06195
uniprot id: F6BLJ2
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

858215:THEXY RS06915
gene id: 858215:THEXY_RS06915
uniprot id: F6BG40
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

858215:THEXY RS05720
gene id: 858215:THEXY_RS05720
uniprot id: F6BKL0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS12075
gene id: 858215:THEXY_RS12075
uniprot id: F6BFT8
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
messages: Homodimer.
messages: In the C-terminal section; belongs to the MurCDEF family.

858215:THEXY RS06280
gene id: 858215:THEXY_RS06280
uniprot id: F6BLL0
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

858215:THEXY RS05615
gene id: 858215:THEXY_RS05615
uniprot id: F6BKJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

858215:THEXY RS11470
gene id: 858215:THEXY_RS11470
uniprot id: F6BLS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

858215:THEXY RS07250
gene id: 858215:THEXY_RS07250
uniprot id: F6BGI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS00985
gene id: 858215:THEXY_RS00985
uniprot id: F6BFV4
names: Similarity
messages: Belongs to the threonine aldolase family.

858215:THEXY RS12060
gene id: 858215:THEXY_RS12060
uniprot id: F6BFT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

858215:THEXY RS09125
gene id: 858215:THEXY_RS09125
uniprot id: F6BIT3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

858215:THEXY RS00655
gene id: 858215:THEXY_RS00655
uniprot id: F6BFA4
names: Similarity
messages: Belongs to the DEAD box helicase family.

858215:THEXY RS05300
gene id: 858215:THEXY_RS05300
uniprot id: F6BK66
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

858215:THEXY RS06095
gene id: 858215:THEXY_RS06095
uniprot id: F6BL35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

858215:THEXY RS11090
gene id: 858215:THEXY_RS11090
uniprot id: F6BL69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

858215:THEXY RS06505
gene id: 858215:THEXY_RS06505
uniprot id: F6BFG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

858215:THEXY RS10840
gene id: 858215:THEXY_RS10840
uniprot id: F6BKR8
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

858215:THEXY RS07660
gene id: 858215:THEXY_RS07660
uniprot id: F6BGY4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

858215:THEXY RS08125
gene id: 858215:THEXY_RS08125
uniprot id: F6BHM3
names: Similarity
messages: Belongs to the transglycosylase Slt family.

858215:THEXY RS03305
gene id: 858215:THEXY_RS03305
uniprot id: F6BI79
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

858215:THEXY RS05475
gene id: 858215:THEXY_RS05475
uniprot id: F6BK99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

858215:THEXY RS01090
gene id: 858215:THEXY_RS01090
uniprot id: F6BFX4
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

858215:THEXY RS00175
gene id: 858215:THEXY_RS00175
uniprot id: F6BKY2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS02505
gene id: 858215:THEXY_RS02505
uniprot id: F6BH81
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS09480
gene id: 858215:THEXY_RS09480
uniprot id: F6BJ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

858215:THEXY RS07775
gene id: 858215:THEXY_RS07775
uniprot id: F6BH07
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

858215:THEXY RS05785
gene id: 858215:THEXY_RS05785
uniprot id: F6BKM4
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

858215:THEXY RS00920
gene id: 858215:THEXY_RS00920
uniprot id: F6BFF4
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS01135
gene id: 858215:THEXY_RS01135
uniprot id: F6BFY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

858215:THEXY RS09330
gene id: 858215:THEXY_RS09330
uniprot id: F6BIX1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

858215:THEXY RS05660
gene id: 858215:THEXY_RS05660
uniprot id: F6BKJ8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

858215:THEXY RS03375
gene id: 858215:THEXY_RS03375
uniprot id: F6BI90
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

858215:THEXY RS00280
gene id: 858215:THEXY_RS00280
uniprot id: F6BLD7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

858215:THEXY RS09245
gene id: 858215:THEXY_RS09245
uniprot id: F6BIV4
names: Similarity
messages: Belongs to the EamA transporter family.

858215:THEXY RS11095
gene id: 858215:THEXY_RS11095
uniprot id: F6BL70
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS08215
gene id: 858215:THEXY_RS08215
uniprot id: F6BHP0
names: Similarity
messages: Belongs to the UPF0340 family.

858215:THEXY RS03035
gene id: 858215:THEXY_RS03035
uniprot id: F6BHW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

858215:THEXY RS10370
gene id: 858215:THEXY_RS10370
uniprot id: F6BKB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS01595
gene id: 858215:THEXY_RS01595
uniprot id: F6BGE4
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

858215:THEXY RS07445
gene id: 858215:THEXY_RS07445
uniprot id: F6BGM7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS11850
gene id: 858215:THEXY_RS11850
uniprot id: F6BFP7
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

858215:THEXY RS07095
gene id: 858215:THEXY_RS07095
uniprot id: F6BG77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

858215:THEXY RS01510
gene id: 858215:THEXY_RS01510
uniprot id: F6BGC6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

858215:THEXY RS12570
gene id: 858215:THEXY_RS12570
uniprot id: F6BK35
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

858215:THEXY RS11740
gene id: 858215:THEXY_RS11740
uniprot id: F6BLX9
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS02890
gene id: 858215:THEXY_RS02890
uniprot id: F6BHM1
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS02385
gene id: 858215:THEXY_RS02385
uniprot id: F6BH57
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

858215:THEXY RS00630
gene id: 858215:THEXY_RS00630
uniprot id: F6BF99
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Belongs to the carbamoyltransferase HypF family.

858215:THEXY RS03445
gene id: 858215:THEXY_RS03445
uniprot id: F6BI89
names: Similarity
messages: Belongs to the UPF0236 family.

858215:THEXY RS06920
gene id: 858215:THEXY_RS06920
uniprot id: F6BG41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

858215:THEXY RS01755
gene id: 858215:THEXY_RS01755
uniprot id: F6BGN7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

858215:THEXY RS02590
gene id: 858215:THEXY_RS02590
uniprot id: F6BHG1
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

858215:THEXY RS03480
gene id: 858215:THEXY_RS03480
uniprot id: F6BIB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

858215:THEXY RS11020
gene id: 858215:THEXY_RS11020
uniprot id: F6BL54
names: Similarity
messages: Belongs to the UPF0045 family.

858215:THEXY RS01280
gene id: 858215:THEXY_RS01280
uniprot id: F6BG07
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

858215:THEXY RS07325
gene id: 858215:THEXY_RS07325
uniprot id: F6BGK4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

858215:THEXY RS09740
gene id: 858215:THEXY_RS09740
uniprot id: F6BJI9
names: Similarity
messages: Belongs to the HepT RNase toxin family.

858215:THEXY RS03500
gene id: 858215:THEXY_RS03500
uniprot id: F6BIB5
names: Similarity
messages: Belongs to the MotB family.

858215:THEXY RS07200
gene id: 858215:THEXY_RS07200
uniprot id: F6BGH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

858215:THEXY RS01110
gene id: 858215:THEXY_RS01110
uniprot id: F6BFX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

858215:THEXY RS03170
gene id: 858215:THEXY_RS03170
uniprot id: F6BHZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

858215:THEXY RS02010
gene id: 858215:THEXY_RS02010
uniprot id: F6BGS6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

858215:THEXY RS10985
gene id: 858215:THEXY_RS10985
uniprot id: F6BKU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS09710
gene id: 858215:THEXY_RS09710
uniprot id: F6BJB1
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

858215:THEXY RS07355
gene id: 858215:THEXY_RS07355
uniprot id: F6BGL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS00270
gene id: 858215:THEXY_RS00270
uniprot id: F6BLD5
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

858215:THEXY RS03785
gene id: 858215:THEXY_RS03785
uniprot id: F6BIN8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

858215:THEXY RS06430
gene id: 858215:THEXY_RS06430
uniprot id: F6BLP0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS07665
gene id: 858215:THEXY_RS07665
uniprot id: F6BGY5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

858215:THEXY RS00125
gene id: 858215:THEXY_RS00125
uniprot id: F6BKX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

858215:THEXY RS00620
gene id: 858215:THEXY_RS00620
uniprot id: F6BF97
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

858215:THEXY RS00090
gene id: 858215:THEXY_RS00090
uniprot id: F6BKW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS08175
gene id: 858215:THEXY_RS08175
uniprot id: F6BHN2
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

858215:THEXY RS06390
gene id: 858215:THEXY_RS06390
uniprot id: F6BLN2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

858215:THEXY RS05680
gene id: 858215:THEXY_RS05680
uniprot id: F6BKK2
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

858215:THEXY RS06995
gene id: 858215:THEXY_RS06995
uniprot id: F6BG56
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

858215:THEXY RS09210
gene id: 858215:THEXY_RS09210
uniprot id: F6BIU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

858215:THEXY RS03055
gene id: 858215:THEXY_RS03055
uniprot id: F6BHW6
names: Similarity
messages: Belongs to the thioesterase PaaI family.

858215:THEXY RS04670
gene id: 858215:THEXY_RS04670
uniprot id: F6BJH0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS00470
gene id: 858215:THEXY_RS00470
uniprot id: F6BLG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

858215:THEXY RS10980
gene id: 858215:THEXY_RS10980
uniprot id: F6BKU6
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

858215:THEXY RS05635
gene id: 858215:THEXY_RS05635
uniprot id: F6BKJ3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

858215:THEXY RS10610
gene id: 858215:THEXY_RS10610
uniprot id: F6BKF7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

858215:THEXY RS07630
gene id: 858215:THEXY_RS07630
uniprot id: F6BGX8
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

858215:THEXY RS07220
gene id: 858215:THEXY_RS07220
uniprot id: F6BGI2
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

858215:THEXY RS01740
gene id: 858215:THEXY_RS01740
uniprot id: F6BGN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

858215:THEXY RS07645
gene id: 858215:THEXY_RS07645
uniprot id: F6BGY1
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

858215:THEXY RS11960
gene id: 858215:THEXY_RS11960
uniprot id: F6BFR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

858215:THEXY RS03205
gene id: 858215:THEXY_RS03205
uniprot id: F6BHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS08135
gene id: 858215:THEXY_RS08135
uniprot id: F6BHM5
names: Similarity
messages: Belongs to the peptidase C40 family.

858215:THEXY RS11835
gene id: 858215:THEXY_RS11835
uniprot id: F6BFP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

858215:THEXY RS04495
gene id: 858215:THEXY_RS04495
uniprot id: F6BJD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

858215:THEXY RS03300
gene id: 858215:THEXY_RS03300
uniprot id: F6BI78
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

858215:THEXY RS09940
gene id: 858215:THEXY_RS09940
uniprot id: F6BJM9
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

858215:THEXY RS05760
gene id: 858215:THEXY_RS05760
uniprot id: F6BKL9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

858215:THEXY RS10145
gene id: 858215:THEXY_RS10145
uniprot id: F6BJZ6
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS05010
gene id: 858215:THEXY_RS05010
uniprot id: F6BJU5
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

858215:THEXY RS10385
gene id: 858215:THEXY_RS10385
uniprot id: F6BKB6
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

858215:THEXY RS07090
gene id: 858215:THEXY_RS07090
uniprot id: F6BG76
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

858215:THEXY RS08305
gene id: 858215:THEXY_RS08305
uniprot id: F6BHQ9
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS06515
gene id: 858215:THEXY_RS06515
uniprot id: F6BFG5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

858215:THEXY RS11450
gene id: 858215:THEXY_RS11450
uniprot id: F6BLS1
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS07430
gene id: 858215:THEXY_RS07430
uniprot id: F6BGM4
names: Similarity
messages: Belongs to the thioredoxin family.

858215:THEXY RS06940
gene id: 858215:THEXY_RS06940
uniprot id: F6BG45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

858215:THEXY RS06855
gene id: 858215:THEXY_RS06855
uniprot id: F6BG28
names: Similarity
messages: Belongs to the DprA/Smf family.

858215:THEXY RS03690
gene id: 858215:THEXY_RS03690
uniprot id: F6BIL9
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

858215:THEXY RS01500
gene id: 858215:THEXY_RS01500
uniprot id: F6BGC4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

858215:THEXY RS07305
gene id: 858215:THEXY_RS07305
uniprot id: F6BGK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

858215:THEXY RS05110
gene id: 858215:THEXY_RS05110
uniprot id: F6BJW5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS05550
gene id: 858215:THEXY_RS05550
uniprot id: F6BKH7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS08140
gene id: 858215:THEXY_RS08140
uniprot id: F6BHM6
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS12050
gene id: 858215:THEXY_RS12050
uniprot id: F6BFT3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

858215:THEXY RS05745
gene id: 858215:THEXY_RS05745
uniprot id: F6BKL5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS01290
gene id: 858215:THEXY_RS01290
uniprot id: F6BG10
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS03370
gene id: 858215:THEXY_RS03370
uniprot id: F6BI89
names: Similarity
messages: Belongs to the UPF0236 family.

858215:THEXY RS06490
gene id: 858215:THEXY_RS06490
uniprot id: F6BLQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

858215:THEXY RS11580
gene id: 858215:THEXY_RS11580
uniprot id: F6BLU7
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

858215:THEXY RS03190
gene id: 858215:THEXY_RS03190
uniprot id: F6BHZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

858215:THEXY RS00275
gene id: 858215:THEXY_RS00275
uniprot id: F6BLD6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

858215:THEXY RS03215
gene id: 858215:THEXY_RS03215
uniprot id: F6BI00
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

858215:THEXY RS12065
gene id: 858215:THEXY_RS12065
uniprot id: F6BFT6
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS01610
gene id: 858215:THEXY_RS01610
uniprot id: F6BGE7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS06370
gene id: 858215:THEXY_RS06370
uniprot id: F6BLM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

858215:THEXY RS00130
gene id: 858215:THEXY_RS00130
uniprot id: F6BKX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS06715
gene id: 858215:THEXY_RS06715
uniprot id: F6BFK6
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

858215:THEXY RS03650
gene id: 858215:THEXY_RS03650
uniprot id: F6BIL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

858215:THEXY RS00800
gene id: 858215:THEXY_RS00800
uniprot id: F6BFD0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS03075
gene id: 858215:THEXY_RS03075
uniprot id: F6BHX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

858215:THEXY RS08240
gene id: 858215:THEXY_RS08240
uniprot id: F6BHP5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS04420
gene id: 858215:THEXY_RS04420
uniprot id: F6BJC0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.

858215:THEXY RS02810
gene id: 858215:THEXY_RS02810
uniprot id: F6BHK4
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

858215:THEXY RS07125
gene id: 858215:THEXY_RS07125
uniprot id: F6BG83
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS09550
gene id: 858215:THEXY_RS09550
uniprot id: F6BJ82
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

858215:THEXY RS04205
gene id: 858215:THEXY_RS04205
uniprot id: F6BJ23
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

858215:THEXY RS05805
gene id: 858215:THEXY_RS05805
uniprot id: F6BKM8
names: Similarity
messages: Belongs to the thioredoxin family.

858215:THEXY RS09660
gene id: 858215:THEXY_RS09660
uniprot id: F6BJA4
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

858215:THEXY RS10100
gene id: 858215:THEXY_RS10100
uniprot id: F6BJY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS04290
gene id: 858215:THEXY_RS04290
uniprot id: F6BJ38
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

858215:THEXY RS04245
gene id: 858215:THEXY_RS04245
uniprot id: F6BJ31
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

858215:THEXY RS00945
gene id: 858215:THEXY_RS00945
uniprot id: F6BFF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

858215:THEXY RS08395
gene id: 858215:THEXY_RS08395
uniprot id: F6BHS7
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

858215:THEXY RS06030
gene id: 858215:THEXY_RS06030
uniprot id: F6BL22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

858215:THEXY RS02670
gene id: 858215:THEXY_RS02670
uniprot id: F6BHH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

858215:THEXY RS09965
gene id: 858215:THEXY_RS09965
uniprot id: F6BJN4
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

858215:THEXY RS07655
gene id: 858215:THEXY_RS07655
uniprot id: F6BGY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

858215:THEXY RS06845
gene id: 858215:THEXY_RS06845
uniprot id: F6BG26
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

858215:THEXY RS09365
gene id: 858215:THEXY_RS09365
uniprot id: F6BIX8
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

858215:THEXY RS11635
gene id: 858215:THEXY_RS11635
uniprot id: F6BLV7
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS00265
gene id: 858215:THEXY_RS00265
uniprot id: F6BLD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

858215:THEXY RS04750
gene id: 858215:THEXY_RS04750
uniprot id: F6BJI5
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

858215:THEXY RS08885
gene id: 858215:THEXY_RS08885
uniprot id: F6BIH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS11795
gene id: 858215:THEXY_RS11795
uniprot id: F6BFN7
names: Cofactor
messages: Binds 1 zinc ion per subunit.

858215:THEXY RS07970
gene id: 858215:THEXY_RS07970
uniprot id: F6BHB8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

858215:THEXY RS12545
gene id: 858215:THEXY_RS12545
uniprot id: F6BFK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

858215:THEXY RS06360
gene id: 858215:THEXY_RS06360
uniprot id: F6BLM6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

858215:THEXY RS08810
gene id: 858215:THEXY_RS08810
uniprot id: F6BIF7
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

858215:THEXY RS06550
gene id: 858215:THEXY_RS06550
uniprot id: F6BFH2
names: Similarity
messages: Belongs to the peptidase M16 family.

858215:THEXY RS05175
gene id: 858215:THEXY_RS05175
uniprot id: F6BK40
names: Similarity
messages: Belongs to the ThiD family.

858215:THEXY RS00910
gene id: 858215:THEXY_RS00910
uniprot id: F6BFF2
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

858215:THEXY RS04405
gene id: 858215:THEXY_RS04405
uniprot id: F6BJB7
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS10775
gene id: 858215:THEXY_RS10775
uniprot id: F6BKQ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS07240
gene id: 858215:THEXY_RS07240
uniprot id: F6BGI6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS07525
gene id: 858215:THEXY_RS07525
uniprot id: F6BGV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

858215:THEXY RS04835
gene id: 858215:THEXY_RS04835
uniprot id: F6BJR3
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

858215:THEXY RS04485
gene id: 858215:THEXY_RS04485
uniprot id: F6BJD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

858215:THEXY RS08060
gene id: 858215:THEXY_RS08060
uniprot id: F6BHD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

858215:THEXY RS06570
gene id: 858215:THEXY_RS06570
uniprot id: F6BFH6
names: Similarity
messages: Belongs to the ribF family.

858215:THEXY RS09380
gene id: 858215:THEXY_RS09380
uniprot id: F6BIY1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS07785
gene id: 858215:THEXY_RS07785
uniprot id: F6BH09
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

858215:THEXY RS01820
gene id: 858215:THEXY_RS01820
uniprot id: F6BGQ0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

858215:THEXY RS11465
gene id: 858215:THEXY_RS11465
uniprot id: F6BLS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

858215:THEXY RS06315
gene id: 858215:THEXY_RS06315
uniprot id: F6BLL7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

858215:THEXY RS04490
gene id: 858215:THEXY_RS04490
uniprot id: F6BJD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

858215:THEXY RS08195
gene id: 858215:THEXY_RS08195
uniprot id: F6BHN6
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS11405
gene id: 858215:THEXY_RS11405
uniprot id: F6BLR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

858215:THEXY RS08720
gene id: 858215:THEXY_RS08720
uniprot id: F6BI65
names: Similarity
messages: Belongs to the phosphohexose mutase family.

858215:THEXY RS03770
gene id: 858215:THEXY_RS03770
uniprot id: F6BIN5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

858215:THEXY RS01550
gene id: 858215:THEXY_RS01550
uniprot id: F6BGD5
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

858215:THEXY RS07450
gene id: 858215:THEXY_RS07450
uniprot id: F6BGM8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS04235
gene id: 858215:THEXY_RS04235
uniprot id: F6BJ29
names: Similarity
messages: Belongs to the UPF0251 family.

858215:THEXY RS11135
gene id: 858215:THEXY_RS11135
uniprot id: F6BL78
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

858215:THEXY RS11105
gene id: 858215:THEXY_RS11105
uniprot id: F6BL72
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

858215:THEXY RS04215
gene id: 858215:THEXY_RS04215
uniprot id: F6BJ25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

858215:THEXY RS00815
gene id: 858215:THEXY_RS00815
uniprot id: F6BFD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

858215:THEXY RS01915
gene id: 858215:THEXY_RS01915
uniprot id: F6BGR9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

858215:THEXY RS02725
gene id: 858215:THEXY_RS02725
uniprot id: F6BHI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

858215:THEXY RS02200
gene id: 858215:THEXY_RS02200
uniprot id: F6BH26
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS04885
gene id: 858215:THEXY_RS04885
uniprot id: F6BJS3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.

858215:THEXY RS06510
gene id: 858215:THEXY_RS06510
uniprot id: F6BFG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

858215:THEXY RS06830
gene id: 858215:THEXY_RS06830
uniprot id: F6BG23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

858215:THEXY RS05520
gene id: 858215:THEXY_RS05520
uniprot id: F6BKA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

858215:THEXY RS07160
gene id: 858215:THEXY_RS07160
uniprot id: F6BGH3
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

858215:THEXY RS09215
gene id: 858215:THEXY_RS09215
uniprot id: F6BIU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

858215:THEXY RS01140
gene id: 858215:THEXY_RS01140
uniprot id: F6BFY4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

858215:THEXY RS11160
gene id: 858215:THEXY_RS11160
uniprot id: F6BL83
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS02290
gene id: 858215:THEXY_RS02290
uniprot id: F6BH40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS01420
gene id: 858215:THEXY_RS01420
uniprot id: F6BGA8
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

858215:THEXY RS10315
gene id: 858215:THEXY_RS10315
uniprot id: F6BK29
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

858215:THEXY RS09840
gene id: 858215:THEXY_RS09840
uniprot id: F6BJK9
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS07115
gene id: 858215:THEXY_RS07115
uniprot id: F6BG81
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

858215:THEXY RS08300
gene id: 858215:THEXY_RS08300
uniprot id: F6BHQ8
names: Similarity
messages: Belongs to the AlaDH/PNT family.

858215:THEXY RS03760
gene id: 858215:THEXY_RS03760
uniprot id: F6BIN3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

858215:THEXY RS07210
gene id: 858215:THEXY_RS07210
uniprot id: F6BGI0
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

858215:THEXY RS01370
gene id: 858215:THEXY_RS01370
uniprot id: F6BG97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

858215:THEXY RS12140
gene id: 858215:THEXY_RS12140
uniprot id: F6BG89
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS02800
gene id: 858215:THEXY_RS02800
uniprot id: F6BHK2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

858215:THEXY RS11155
gene id: 858215:THEXY_RS11155
uniprot id: F6BL82
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS09765
gene id: 858215:THEXY_RS09765
uniprot id: F6BJJ4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

858215:THEXY RS00795
gene id: 858215:THEXY_RS00795
uniprot id: F6BFC9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

858215:THEXY RS11395
gene id: 858215:THEXY_RS11395
uniprot id: F6BLR0
names: Similarity
messages: Belongs to the peptidase S41A family.

858215:THEXY RS05570
gene id: 858215:THEXY_RS05570
uniprot id: F6BKI1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

858215:THEXY RS11350
gene id: 858215:THEXY_RS11350
uniprot id: F6BLB9
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS04775
gene id: 858215:THEXY_RS04775
uniprot id: F6BJQ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

858215:THEXY RS09240
gene id: 858215:THEXY_RS09240
uniprot id: F6BIV3
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS05480
gene id: 858215:THEXY_RS05480
uniprot id: F6BKA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

858215:THEXY RS06825
gene id: 858215:THEXY_RS06825
uniprot id: F6BG22
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

858215:THEXY RS00895
gene id: 858215:THEXY_RS00895
uniprot id: F6BFE9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

858215:THEXY RS01720
gene id: 858215:THEXY_RS01720
uniprot id: F6BGG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

858215:THEXY RS06980
gene id: 858215:THEXY_RS06980
uniprot id: F6BG53
names: Function
names: Similarity
messages: Belongs to the FapR family.
messages: Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.

858215:THEXY RS08890
gene id: 858215:THEXY_RS08890
uniprot id: F6BIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS04950
gene id: 858215:THEXY_RS04950
uniprot id: F6BJT6
names: Function
messages: Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.

858215:THEXY RS10205
gene id: 858215:THEXY_RS10205
uniprot id: F6BK08
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

858215:THEXY RS10415
gene id: 858215:THEXY_RS10415
uniprot id: F6BKC2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

858215:THEXY RS04100
gene id: 858215:THEXY_RS04100
uniprot id: F6BJ02
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

858215:THEXY RS05455
gene id: 858215:THEXY_RS05455
uniprot id: F6BK95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsL family.
messages: Cell membrane
messages: Essential cell division protein.
messages: Membrane

858215:THEXY RS06470
gene id: 858215:THEXY_RS06470
uniprot id: F6BLP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

858215:THEXY RS03800
gene id: 858215:THEXY_RS03800
uniprot id: F6BIP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS12115
gene id: 858215:THEXY_RS12115
uniprot id: F6BFU6
names: Similarity
messages: Belongs to the ParB family.

858215:THEXY RS11270
gene id: 858215:THEXY_RS11270
uniprot id: F6BLA2
names: Similarity
messages: Belongs to the EamA transporter family.

858215:THEXY RS05515
gene id: 858215:THEXY_RS05515
uniprot id: F6BKA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

858215:THEXY RS06850
gene id: 858215:THEXY_RS06850
uniprot id: F6BG27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

858215:THEXY RS02980
gene id: 858215:THEXY_RS02980
uniprot id: F6BHV1
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

858215:THEXY RS08025
gene id: 858215:THEXY_RS08025
uniprot id: F6BHC9
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

858215:THEXY RS08295
gene id: 858215:THEXY_RS08295
uniprot id: F6BHQ7
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS04330
gene id: 858215:THEXY_RS04330
uniprot id: F6BJ43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

858215:THEXY RS04210
gene id: 858215:THEXY_RS04210
uniprot id: F6BJ24
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

858215:THEXY RS09825
gene id: 858215:THEXY_RS09825
uniprot id: F6BJK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

858215:THEXY RS01430
gene id: 858215:THEXY_RS01430
uniprot id: F6BGB0
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

858215:THEXY RS08400
gene id: 858215:THEXY_RS08400
uniprot id: F6BHS8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Cytoplasm

858215:THEXY RS01010
gene id: 858215:THEXY_RS01010
uniprot id: F0DSR4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

858215:THEXY RS03995
gene id: 858215:THEXY_RS03995
uniprot id: F6BIR7
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS11415
gene id: 858215:THEXY_RS11415
uniprot id: F6BLR4
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

858215:THEXY RS10925
gene id: 858215:THEXY_RS10925
uniprot id: F6BKT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

858215:THEXY RS10770
gene id: 858215:THEXY_RS10770
uniprot id: F0DSR4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

858215:THEXY RS08695
gene id: 858215:THEXY_RS08695
uniprot id: F6BI60
names: Similarity
messages: Belongs to the UDPGP type 2 family.

858215:THEXY RS05185
gene id: 858215:THEXY_RS05185
uniprot id: F6BK42
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

858215:THEXY RS02720
gene id: 858215:THEXY_RS02720
uniprot id: F6BHI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

858215:THEXY RS07050
gene id: 858215:THEXY_RS07050
uniprot id: F6BG67
names: Similarity
messages: Belongs to the asp23 family.

858215:THEXY RS11745
gene id: 858215:THEXY_RS11745
uniprot id: F6BLY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS10880
gene id: 858215:THEXY_RS10880
uniprot id: F6BKS6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

858215:THEXY RS07735
gene id: 858215:THEXY_RS07735
uniprot id: F6BGZ9
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

858215:THEXY RS01710
gene id: 858215:THEXY_RS01710
uniprot id: F6BGG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

858215:THEXY RS00135
gene id: 858215:THEXY_RS00135
uniprot id: F6BKX7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS09260
gene id: 858215:THEXY_RS09260
uniprot id: F6BIV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

858215:THEXY RS01460
gene id: 858215:THEXY_RS01460
uniprot id: F6BGB6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS06630
gene id: 858215:THEXY_RS06630
uniprot id: F6BFI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

858215:THEXY RS08150
gene id: 858215:THEXY_RS08150
uniprot id: F6BHM7
names: Similarity
messages: Belongs to the NadC/ModD family.

858215:THEXY RS06105
gene id: 858215:THEXY_RS06105
uniprot id: F6BL37
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

858215:THEXY RS10765
gene id: 858215:THEXY_RS10765
uniprot id: F6BKQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

858215:THEXY RS08055
gene id: 858215:THEXY_RS08055
uniprot id: F6BHD5
names: Similarity
messages: Belongs to the UPF0758 family.

858215:THEXY RS06585
gene id: 858215:THEXY_RS06585
uniprot id: F6BFH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

858215:THEXY RS07565
gene id: 858215:THEXY_RS07565
uniprot id: F6BGW6
names: Similarity
messages: Belongs to the YggT family.

858215:THEXY RS05935
gene id: 858215:THEXY_RS05935
uniprot id: F6BL03
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS10240
gene id: 858215:THEXY_RS10240
uniprot id: F6BK14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.

858215:THEXY RS01590
gene id: 858215:THEXY_RS01590
uniprot id: F6BGE3
names: Similarity
messages: Belongs to the ycf81 family.

858215:THEXY RS03780
gene id: 858215:THEXY_RS03780
uniprot id: F6BIN7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

858215:THEXY RS02365
gene id: 858215:THEXY_RS02365
uniprot id: F6BH53
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

858215:THEXY RS08455
gene id: 858215:THEXY_RS08455
uniprot id: F6BI14
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family. DapH subfamily.
messages: Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.

858215:THEXY RS02910
gene id: 858215:THEXY_RS02910
uniprot id: F6BHT7
names: Similarity
messages: Belongs to the ribulokinase family.

858215:THEXY RS08820
gene id: 858215:THEXY_RS08820
uniprot id: F6BIF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS04595
gene id: 858215:THEXY_RS04595
uniprot id: F6BJF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

858215:THEXY RS10535
gene id: 858215:THEXY_RS10535
uniprot id: F6BKE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS03640
gene id: 858215:THEXY_RS03640
uniprot id: F6BIK9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

858215:THEXY RS01835
gene id: 858215:THEXY_RS01835
uniprot id: F6BGQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

858215:THEXY RS07455
gene id: 858215:THEXY_RS07455
uniprot id: F6BGM9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

858215:THEXY RS00610
gene id: 858215:THEXY_RS00610
uniprot id: F6BF95
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

858215:THEXY RS02480
gene id: 858215:THEXY_RS02480
uniprot id: F6BH76
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS03825
gene id: 858215:THEXY_RS03825
uniprot id: F6BIP6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

858215:THEXY RS07040
gene id: 858215:THEXY_RS07040
uniprot id: F6BG65
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

858215:THEXY RS03275
gene id: 858215:THEXY_RS03275
uniprot id: F6BI73
names: Function
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

858215:THEXY RS03655
gene id: 858215:THEXY_RS03655
uniprot id: F6BIL2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

858215:THEXY RS00385
gene id: 858215:THEXY_RS00385
uniprot id: F6BLF4
names: Similarity
messages: Belongs to the class-I fumarase family.

858215:THEXY RS05545
gene id: 858215:THEXY_RS05545
uniprot id: F6BKH6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

858215:THEXY RS08675
gene id: 858215:THEXY_RS08675
uniprot id: F6BI56
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

858215:THEXY RS04730
gene id: 858215:THEXY_RS04730
uniprot id: F6BJI2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS00780
gene id: 858215:THEXY_RS00780
uniprot id: F6BFC6
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

858215:THEXY RS10130
gene id: 858215:THEXY_RS10130
uniprot id: F6BJZ3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

858215:THEXY RS08020
gene id: 858215:THEXY_RS08020
uniprot id: F6BHC8
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

858215:THEXY RS03235
gene id: 858215:THEXY_RS03235
uniprot id: F6BI04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS00480
gene id: 858215:THEXY_RS00480
uniprot id: F6BLH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

858215:THEXY RS02640
gene id: 858215:THEXY_RS02640
uniprot id: F6BHH1
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS11485
gene id: 858215:THEXY_RS11485
uniprot id: F6BLS8
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

858215:THEXY RS11130
gene id: 858215:THEXY_RS11130
uniprot id: F6BL77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

858215:THEXY RS05565
gene id: 858215:THEXY_RS05565
uniprot id: F6BKI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

858215:THEXY RS01725
gene id: 858215:THEXY_RS01725
uniprot id: F6BGH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

858215:THEXY RS08130
gene id: 858215:THEXY_RS08130
uniprot id: F6BHM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

858215:THEXY RS04275
gene id: 858215:THEXY_RS04275
uniprot id: F6BJ35
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

858215:THEXY RS11050
gene id: 858215:THEXY_RS11050
uniprot id: F6BL61
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS05080
gene id: 858215:THEXY_RS05080
uniprot id: F6BJV9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS07350
gene id: 858215:THEXY_RS07350
uniprot id: F6BGK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

858215:THEXY RS03260
gene id: 858215:THEXY_RS03260
uniprot id: F6BI70
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

858215:THEXY RS04150
gene id: 858215:THEXY_RS04150
uniprot id: F6BJ12
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

858215:THEXY RS03610
gene id: 858215:THEXY_RS03610
uniprot id: F6BID6
names: Similarity
messages: Belongs to the peptidase S8 family.

858215:THEXY RS03270
gene id: 858215:THEXY_RS03270
uniprot id: F6BI72
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

858215:THEXY RS02540
gene id: 858215:THEXY_RS02540
uniprot id: F6BHF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

858215:THEXY RS01490
gene id: 858215:THEXY_RS01490
uniprot id: F6BGC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0291 family.
messages: Cytoplasm

858215:THEXY RS07195
gene id: 858215:THEXY_RS07195
uniprot id: F6BGH7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS01425
gene id: 858215:THEXY_RS01425
uniprot id: F6BGA9
names: Similarity
messages: Belongs to the GerABKA family.

858215:THEXY RS10725
gene id: 858215:THEXY_RS10725
uniprot id: F6BKP5
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS04715
gene id: 858215:THEXY_RS04715
uniprot id: F6BJH9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS06250
gene id: 858215:THEXY_RS06250
uniprot id: F6BLK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

858215:THEXY RS01825
gene id: 858215:THEXY_RS01825
uniprot id: F6BGQ1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

858215:THEXY RS01870
gene id: 858215:THEXY_RS01870
uniprot id: F6BGR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

858215:THEXY RS06425
gene id: 858215:THEXY_RS06425
uniprot id: F6BLN9
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

858215:THEXY RS01810
gene id: 858215:THEXY_RS01810
uniprot id: F6BGP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

858215:THEXY RS04740
gene id: 858215:THEXY_RS04740
uniprot id: F6BJI3
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS02545
gene id: 858215:THEXY_RS02545
uniprot id: F6BHF2
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

858215:THEXY RS06135
gene id: 858215:THEXY_RS06135
uniprot id: F6BL43
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

858215:THEXY RS04830
gene id: 858215:THEXY_RS04830
uniprot id: F6BJR2
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

858215:THEXY RS03685
gene id: 858215:THEXY_RS03685
uniprot id: F6BIL8
names: Similarity
messages: Belongs to the GARS family.

858215:THEXY RS06765
gene id: 858215:THEXY_RS06765
uniprot id: F6BFL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

858215:THEXY RS00900
gene id: 858215:THEXY_RS00900
uniprot id: F6BFF0
names: Similarity
messages: Belongs to the SleB family.

858215:THEXY RS09340
gene id: 858215:THEXY_RS09340
uniprot id: F6BIX3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

858215:THEXY RS07270
gene id: 858215:THEXY_RS07270
uniprot id: F6BGJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

858215:THEXY RS09285
gene id: 858215:THEXY_RS09285
uniprot id: F6BIW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

858215:THEXY RS09300
gene id: 858215:THEXY_RS09300
uniprot id: F6BIW5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

858215:THEXY RS01075
gene id: 858215:THEXY_RS01075
uniprot id: F6BFX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

858215:THEXY RS09875
gene id: 858215:THEXY_RS09875
uniprot id: F6BJL6
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

858215:THEXY RS05235
gene id: 858215:THEXY_RS05235
uniprot id: F6BK52
names: Similarity
messages: Belongs to the asparagine synthetase family.

858215:THEXY RS01785
gene id: 858215:THEXY_RS01785
uniprot id: F6BGP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

858215:THEXY RS08570
gene id: 858215:THEXY_RS08570
uniprot id: F6BI37
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

858215:THEXY RS04955
gene id: 858215:THEXY_RS04955
uniprot id: F6BJT7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

858215:THEXY RS07230
gene id: 858215:THEXY_RS07230
uniprot id: F6BGI4
names: Similarity
messages: Belongs to the HypE family.

858215:THEXY RS00885
gene id: 858215:THEXY_RS00885
uniprot id: F6BFE7
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

858215:THEXY RS10150
gene id: 858215:THEXY_RS10150
uniprot id: F6BJZ7
names: Similarity
messages: Belongs to the UPF0111 family.

858215:THEXY RS07290
gene id: 858215:THEXY_RS07290
uniprot id: F6BGJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

858215:THEXY RS08155
gene id: 858215:THEXY_RS08155
uniprot id: F6BHM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane

858215:THEXY RS10905
gene id: 858215:THEXY_RS10905
uniprot id: F6BKT1
names: Similarity
messages: Belongs to the UPF0175 family.

858215:THEXY RS02765
gene id: 858215:THEXY_RS02765
uniprot id: F6BHJ5
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS10455
gene id: 858215:THEXY_RS10455
uniprot id: F6BKD0
names: Similarity
messages: Belongs to the UPF0749 family.

858215:THEXY RS07515
gene id: 858215:THEXY_RS07515
uniprot id: F6BGV6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS10810
gene id: 858215:THEXY_RS10810
uniprot id: F6BKR2
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS08650
gene id: 858215:THEXY_RS08650
uniprot id: F6BI51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

858215:THEXY RS08610
gene id: 858215:THEXY_RS08610
uniprot id: F6BI43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

858215:THEXY RS03225
gene id: 858215:THEXY_RS03225
uniprot id: F6BI02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane

858215:THEXY RS05495
gene id: 858215:THEXY_RS05495
uniprot id: F6BKA3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS06495
gene id: 858215:THEXY_RS06495
uniprot id: F6BLQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

858215:THEXY RS06440
gene id: 858215:THEXY_RS06440
uniprot id: F6BLP2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

858215:THEXY RS07215
gene id: 858215:THEXY_RS07215
uniprot id: F6BGI1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS08265
gene id: 858215:THEXY_RS08265
uniprot id: F6BHQ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS04660
gene id: 858215:THEXY_RS04660
uniprot id: F6BJG8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS05620
gene id: 858215:THEXY_RS05620
uniprot id: F6BKJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

858215:THEXY RS06010
gene id: 858215:THEXY_RS06010
uniprot id: F6BL18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

858215:THEXY RS00880
gene id: 858215:THEXY_RS00880
uniprot id: F6BFE6
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

858215:THEXY RS06575
gene id: 858215:THEXY_RS06575
uniprot id: F6BFH7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

858215:THEXY RS01860
gene id: 858215:THEXY_RS01860
uniprot id: F6BGQ8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

858215:THEXY RS06960
gene id: 858215:THEXY_RS06960
uniprot id: F6BG49
names: Similarity
messages: Belongs to the fabD family.

858215:THEXY RS03665
gene id: 858215:THEXY_RS03665
uniprot id: F6BIL4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

858215:THEXY RS05740
gene id: 858215:THEXY_RS05740
uniprot id: F6BKL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

858215:THEXY RS10730
gene id: 858215:THEXY_RS10730
uniprot id: F6BKP6
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS02095
gene id: 858215:THEXY_RS02095
uniprot id: F6BGU3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS01015
gene id: 858215:THEXY_RS01015
uniprot id: F6BFW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Membrane

858215:THEXY RS00150
gene id: 858215:THEXY_RS00150
uniprot id: F6BKX8
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

858215:THEXY RS07130
gene id: 858215:THEXY_RS07130
uniprot id: F6BG84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

858215:THEXY RS09165
gene id: 858215:THEXY_RS09165
uniprot id: F6BIU0
names: Similarity
messages: Belongs to the polysaccharide synthase family.

858215:THEXY RS01560
gene id: 858215:THEXY_RS01560
uniprot id: F6BGD7
names: Similarity
messages: Belongs to the CtsR family.

858215:THEXY RS00225
gene id: 858215:THEXY_RS00225
uniprot id: F0DSR4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

858215:THEXY RS00380
gene id: 858215:THEXY_RS00380
uniprot id: F6BLF3
names: Similarity
messages: Belongs to the class-I fumarase family.

858215:THEXY RS07155
gene id: 858215:THEXY_RS07155
uniprot id: F6BGH2
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

858215:THEXY RS05610
gene id: 858215:THEXY_RS05610
uniprot id: F6BKI9
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

858215:THEXY RS10560
gene id: 858215:THEXY_RS10560
uniprot id: F6BKE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rhamnose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
messages: Cytoplasm

858215:THEXY RS03630
gene id: 858215:THEXY_RS03630
uniprot id: F6BIE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

858215:THEXY RS06925
gene id: 858215:THEXY_RS06925
uniprot id: F6BG42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

858215:THEXY RS04760
gene id: 858215:THEXY_RS04760
uniprot id: F6BJI7
names: Similarity
messages: Belongs to the OsmC/Ohr family.

858215:THEXY RS12125
gene id: 858215:THEXY_RS12125
uniprot id: F6BFU8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

858215:THEXY RS09295
gene id: 858215:THEXY_RS09295
uniprot id: F6BIW4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

858215:THEXY RS03110
gene id: 858215:THEXY_RS03110
uniprot id: F6BHX7
names: Similarity
messages: Belongs to the universal stress protein A family.

858215:THEXY RS03070
gene id: 858215:THEXY_RS03070
uniprot id: F6BHW9
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS00095
gene id: 858215:THEXY_RS00095
uniprot id: F6BKW8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS02805
gene id: 858215:THEXY_RS02805
uniprot id: F6BHK3
names: Cofactor
names: Similarity
messages: Belongs to the PHP family.
messages: Binds 3 Zn(2+) ions per subunit.

858215:THEXY RS02900
gene id: 858215:THEXY_RS02900
uniprot id: F6BHT5
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS05825
gene id: 858215:THEXY_RS05825
uniprot id: F6BKN2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

858215:THEXY RS04180
gene id: 858215:THEXY_RS04180
uniprot id: F6BJ18
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

858215:THEXY RS00960
gene id: 858215:THEXY_RS00960
uniprot id: F6BFG2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

858215:THEXY RS00785
gene id: 858215:THEXY_RS00785
uniprot id: F6BFC7
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

858215:THEXY RS04240
gene id: 858215:THEXY_RS04240
uniprot id: F6BJ30
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

858215:THEXY RS03670
gene id: 858215:THEXY_RS03670
uniprot id: F6BIL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

858215:THEXY RS00360
gene id: 858215:THEXY_RS00360
uniprot id: F6BLE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS11770
gene id: 858215:THEXY_RS11770
uniprot id: F6BFN2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS11380
gene id: 858215:THEXY_RS11380
uniprot id: F6BLQ7
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

858215:THEXY RS06840
gene id: 858215:THEXY_RS06840
uniprot id: F6BG25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

858215:THEXY RS00645
gene id: 858215:THEXY_RS00645
uniprot id: F6BFA2
names: Similarity
messages: Belongs to the HypE family.

858215:THEXY RS08180
gene id: 858215:THEXY_RS08180
uniprot id: F6BHN3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

858215:THEXY RS01865
gene id: 858215:THEXY_RS01865
uniprot id: F6BGQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

858215:THEXY RS04605
gene id: 858215:THEXY_RS04605
uniprot id: F6BJF7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

858215:THEXY RS09320
gene id: 858215:THEXY_RS09320
uniprot id: F6BIW9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

858215:THEXY RS06865
gene id: 858215:THEXY_RS06865
uniprot id: F6BG30
names: Similarity
messages: Belongs to the UPF0102 family.

858215:THEXY RS00260
gene id: 858215:THEXY_RS00260
uniprot id: F6BLD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

858215:THEXY RS06205
gene id: 858215:THEXY_RS06205
uniprot id: F6BLJ4
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor family.
messages: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.

858215:THEXY RS04845
gene id: 858215:THEXY_RS04845
uniprot id: F6BJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS06760
gene id: 858215:THEXY_RS06760
uniprot id: F6BFL5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

858215:THEXY RS12085
gene id: 858215:THEXY_RS12085
uniprot id: F6BFU0
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

858215:THEXY RS11680
gene id: 858215:THEXY_RS11680
uniprot id: F6BLW6
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

858215:THEXY RS01730
gene id: 858215:THEXY_RS01730
uniprot id: F6BGH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

858215:THEXY RS04505
gene id: 858215:THEXY_RS04505
uniprot id: F6BJD7
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS11735
gene id: 858215:THEXY_RS11735
uniprot id: F6BLX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

858215:THEXY RS07460
gene id: 858215:THEXY_RS07460
uniprot id: F6BGN0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

858215:THEXY RS01775
gene id: 858215:THEXY_RS01775
uniprot id: F6BGP1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

858215:THEXY RS06435
gene id: 858215:THEXY_RS06435
uniprot id: F6BLP1
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

858215:THEXY RS02755
gene id: 858215:THEXY_RS02755
uniprot id: F6BHJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

858215:THEXY RS01455
gene id: 858215:THEXY_RS01455
uniprot id: F6BGB5
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

858215:THEXY RS02295
gene id: 858215:THEXY_RS02295
uniprot id: F6BH41
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

858215:THEXY RS01675
gene id: 858215:THEXY_RS01675
uniprot id: F6BGG0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

858215:THEXY RS08520
gene id: 858215:THEXY_RS08520
uniprot id: F6BI27
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

858215:THEXY RS08420
gene id: 858215:THEXY_RS08420
uniprot id: F6BHT2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS09790
gene id: 858215:THEXY_RS09790
uniprot id: F6BJJ9
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

858215:THEXY RS08015
gene id: 858215:THEXY_RS08015
uniprot id: F6BHC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

858215:THEXY RS11230
gene id: 858215:THEXY_RS11230
uniprot id: F6BL94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

858215:THEXY RS01765
gene id: 858215:THEXY_RS01765
uniprot id: F6BGN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

858215:THEXY RS01690
gene id: 858215:THEXY_RS01690
uniprot id: F6BGG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

858215:THEXY RS05180
gene id: 858215:THEXY_RS05180
uniprot id: F6BK41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

858215:THEXY RS12150
gene id: 858215:THEXY_RS12150
uniprot id: F6BG91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

858215:THEXY RS11830
gene id: 858215:THEXY_RS11830
uniprot id: F6BFP3
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

858215:THEXY RS06900
gene id: 858215:THEXY_RS06900
uniprot id: F6BG37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

858215:THEXY RS00505
gene id: 858215:THEXY_RS00505
uniprot id: F6BLH6
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

858215:THEXY RS00070
gene id: 858215:THEXY_RS00070
uniprot id: F6BKW3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS03675
gene id: 858215:THEXY_RS03675
uniprot id: F6BIL6
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS07920
gene id: 858215:THEXY_RS07920
uniprot id: F6BHA7
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

858215:THEXY RS03765
gene id: 858215:THEXY_RS03765
uniprot id: F6BIN4
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS04930
gene id: 858215:THEXY_RS04930
uniprot id: F6BJT2
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS08200
gene id: 858215:THEXY_RS08200
uniprot id: F6BHN7
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS07850
gene id: 858215:THEXY_RS07850
uniprot id: F6BH96
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

858215:THEXY RS10195
gene id: 858215:THEXY_RS10195
uniprot id: F6BK06
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

858215:THEXY RS05950
gene id: 858215:THEXY_RS05950
uniprot id: F6BL06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS05925
gene id: 858215:THEXY_RS05925
uniprot id: F6BL01
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

858215:THEXY RS04850
gene id: 858215:THEXY_RS04850
uniprot id: F6BJR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS08385
gene id: 858215:THEXY_RS08385
uniprot id: F6BHS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

858215:THEXY RS01120
gene id: 858215:THEXY_RS01120
uniprot id: F6BFY0
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

858215:THEXY RS09485
gene id: 858215:THEXY_RS09485
uniprot id: F6BJ69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

858215:THEXY RS08700
gene id: 858215:THEXY_RS08700
uniprot id: F6BI61
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

858215:THEXY RS12015
gene id: 858215:THEXY_RS12015
uniprot id: F6BFS6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

858215:THEXY RS01620
gene id: 858215:THEXY_RS01620
uniprot id: F6BGE9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

858215:THEXY RS06120
gene id: 858215:THEXY_RS06120
uniprot id: F6BL40
names: Similarity
messages: Belongs to the TlyA family.

858215:THEXY RS07955
gene id: 858215:THEXY_RS07955
uniprot id: F6BHB5
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

858215:THEXY RS09060
gene id: 858215:THEXY_RS09060
uniprot id: F6BIK8
names: Similarity
messages: Belongs to the SecB family.

858215:THEXY RS02210
gene id: 858215:THEXY_RS02210
uniprot id: F6BH28
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

858215:THEXY RS01695
gene id: 858215:THEXY_RS01695
uniprot id: F6BGG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

858215:THEXY RS11100
gene id: 858215:THEXY_RS11100
uniprot id: F6BL71
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

858215:THEXY RS03660
gene id: 858215:THEXY_RS03660
uniprot id: F6BIL3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

858215:THEXY RS01155
gene id: 858215:THEXY_RS01155
uniprot id: F6BFY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS10260
gene id: 858215:THEXY_RS10260
uniprot id: F6BK18
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS06870
gene id: 858215:THEXY_RS06870
uniprot id: F6BG31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS12020
gene id: 858215:THEXY_RS12020
uniprot id: F6BFS7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

858215:THEXY RS04200
gene id: 858215:THEXY_RS04200
uniprot id: F6BJ22
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

858215:THEXY RS03485
gene id: 858215:THEXY_RS03485
uniprot id: F6BIB2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

858215:THEXY RS06885
gene id: 858215:THEXY_RS06885
uniprot id: F6BG34
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

858215:THEXY RS08335
gene id: 858215:THEXY_RS08335
uniprot id: F6BHR5
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

858215:THEXY RS07625
gene id: 858215:THEXY_RS07625
uniprot id: F6BGX7
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

858215:THEXY RS07310
gene id: 858215:THEXY_RS07310
uniprot id: F6BGK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

858215:THEXY RS11575
gene id: 858215:THEXY_RS11575
uniprot id: F6BLU6
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

858215:THEXY RS06405
gene id: 858215:THEXY_RS06405
uniprot id: F6BLN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

858215:THEXY RS03085
gene id: 858215:THEXY_RS03085
uniprot id: F6BHX2
names: Function
names: Subcellular Location Annotation
messages: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).
messages: Cytoplasm

858215:THEXY RS06400
gene id: 858215:THEXY_RS06400
uniprot id: F6BLN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

858215:THEXY RS04560
gene id: 858215:THEXY_RS04560
uniprot id: F6BJE8
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS07505
gene id: 858215:THEXY_RS07505
uniprot id: F6BGV4
names: Similarity
messages: Belongs to the TrpF family.

858215:THEXY RS08475
gene id: 858215:THEXY_RS08475
uniprot id: F6BI18
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

858215:THEXY RS09220
gene id: 858215:THEXY_RS09220
uniprot id: F6BIU9
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS05085
gene id: 858215:THEXY_RS05085
uniprot id: F6BJW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

858215:THEXY RS12550
gene id: 858215:THEXY_RS12550
uniprot id: F6BFK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Role in flagellar biosynthesis.

858215:THEXY RS00040
gene id: 858215:THEXY_RS00040
uniprot id: F6BKV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

858215:THEXY RS00935
gene id: 858215:THEXY_RS00935
uniprot id: F6BFF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

858215:THEXY RS04170
gene id: 858215:THEXY_RS04170
uniprot id: F6BJ16
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

858215:THEXY RS04615
gene id: 858215:THEXY_RS04615
uniprot id: F6BJF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

858215:THEXY RS02325
gene id: 858215:THEXY_RS02325
uniprot id: F6BH45
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS01415
gene id: 858215:THEXY_RS01415
uniprot id: F6BGA7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS00035
gene id: 858215:THEXY_RS00035
uniprot id: F6BKV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

858215:THEXY RS07730
gene id: 858215:THEXY_RS07730
uniprot id: F6BGZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

858215:THEXY RS04545
gene id: 858215:THEXY_RS04545
uniprot id: F6BJE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

858215:THEXY RS12040
gene id: 858215:THEXY_RS12040
uniprot id: F6BFT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

858215:THEXY RS00590
gene id: 858215:THEXY_RS00590
uniprot id: F6BF91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Membrane

858215:THEXY RS08505
gene id: 858215:THEXY_RS08505
uniprot id: F6BI24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS09325
gene id: 858215:THEXY_RS09325
uniprot id: F6BIX0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

858215:THEXY RS06245
gene id: 858215:THEXY_RS06245
uniprot id: F6BLK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

858215:THEXY RS10035
gene id: 858215:THEXY_RS10035
uniprot id: F6BJX4
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS11980
gene id: 858215:THEXY_RS11980
uniprot id: F6BFR9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

858215:THEXY RS02795
gene id: 858215:THEXY_RS02795
uniprot id: F6BHK1
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

858215:THEXY RS05290
gene id: 858215:THEXY_RS05290
uniprot id: F6BK64
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

858215:THEXY RS06735
gene id: 858215:THEXY_RS06735
uniprot id: F6BFL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

858215:THEXY RS05910
gene id: 858215:THEXY_RS05910
uniprot id: F6BKZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
messages: Homodimer.

858215:THEXY RS01665
gene id: 858215:THEXY_RS01665
uniprot id: F6BGF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

858215:THEXY RS01605
gene id: 858215:THEXY_RS01605
uniprot id: F6BGE6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS01750
gene id: 858215:THEXY_RS01750
uniprot id: F6BGN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

858215:THEXY RS10500
gene id: 858215:THEXY_RS10500
uniprot id: F6BKD9
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS09450
gene id: 858215:THEXY_RS09450
uniprot id: F6BJ62
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

858215:THEXY RS05320
gene id: 858215:THEXY_RS05320
uniprot id: F6BK70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

858215:THEXY RS03795
gene id: 858215:THEXY_RS03795
uniprot id: F6BIP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS02865
gene id: 858215:THEXY_RS02865
uniprot id: F6BHL6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

858215:THEXY RS08045
gene id: 858215:THEXY_RS08045
uniprot id: F6BHD3
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

858215:THEXY RS05535
gene id: 858215:THEXY_RS05535
uniprot id: F6BKH4
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

858215:THEXY RS06910
gene id: 858215:THEXY_RS06910
uniprot id: F6BG39
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

858215:THEXY RS05415
gene id: 858215:THEXY_RS05415
uniprot id: F6BK87
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

858215:THEXY RS01105
gene id: 858215:THEXY_RS01105
uniprot id: F6BFX7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS05530
gene id: 858215:THEXY_RS05530
uniprot id: F6BKH3
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

858215:THEXY RS04860
gene id: 858215:THEXY_RS04860
uniprot id: F6BJR8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

858215:THEXY RS09880
gene id: 858215:THEXY_RS09880
uniprot id: F6BJL7
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

858215:THEXY RS08090
gene id: 858215:THEXY_RS08090
uniprot id: F6BHE2
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

858215:THEXY RS07895
gene id: 858215:THEXY_RS07895
uniprot id: F6BHA2
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

858215:THEXY RS10875
gene id: 858215:THEXY_RS10875
uniprot id: F6BKS5
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

858215:THEXY RS04005
gene id: 858215:THEXY_RS04005
uniprot id: F6BIR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

858215:THEXY RS00085
gene id: 858215:THEXY_RS00085
uniprot id: F6BKW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

858215:THEXY RS09725
gene id: 858215:THEXY_RS09725
uniprot id: F6BJB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS01085
gene id: 858215:THEXY_RS01085
uniprot id: F6BFX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

858215:THEXY RS02420
gene id: 858215:THEXY_RS02420
uniprot id: F6BH64
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

858215:THEXY RS01575
gene id: 858215:THEXY_RS01575
uniprot id: F6BGE0
names: Similarity
messages: Belongs to the ClpA/ClpB family.

858215:THEXY RS12130
gene id: 858215:THEXY_RS12130
uniprot id: F6BFU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

858215:THEXY RS00045
gene id: 858215:THEXY_RS00045
uniprot id: F6BKV8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

858215:THEXY RS01320
gene id: 858215:THEXY_RS01320
uniprot id: F6BG16
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

858215:THEXY RS11075
gene id: 858215:THEXY_RS11075
uniprot id: F6BL66
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

858215:THEXY RS10660
gene id: 858215:THEXY_RS10660
uniprot id: F6BKG7
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

858215:THEXY RS11240
gene id: 858215:THEXY_RS11240
uniprot id: F6BL96
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

858215:THEXY RS08405
gene id: 858215:THEXY_RS08405
uniprot id: F6BHS9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

858215:THEXY RS08040
gene id: 858215:THEXY_RS08040
uniprot id: F6BHD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

858215:THEXY RS06005
gene id: 858215:THEXY_RS06005
uniprot id: F6BL17
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

858215:THEXY RS09885
gene id: 858215:THEXY_RS09885
uniprot id: F6BJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS06880
gene id: 858215:THEXY_RS06880
uniprot id: F6BG33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

858215:THEXY RS10975
gene id: 858215:THEXY_RS10975
uniprot id: F6BKU5
names: Similarity
names: Subunit
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

858215:THEXY RS08560
gene id: 858215:THEXY_RS08560
uniprot id: F6BI35
names: Similarity
messages: Belongs to the UPF0236 family.

858215:THEXY RS11995
gene id: 858215:THEXY_RS11995
uniprot id: F6BFS2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS09315
gene id: 858215:THEXY_RS09315
uniprot id: F6BIW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

858215:THEXY RS05510
gene id: 858215:THEXY_RS05510
uniprot id: F6BKA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

858215:THEXY RS07150
gene id: 858215:THEXY_RS07150
uniprot id: F6BG88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS04020
gene id: 858215:THEXY_RS04020
uniprot id: F6BIS2
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

858215:THEXY RS08010
gene id: 858215:THEXY_RS08010
uniprot id: F6BHC6
names: Caution
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS10750
gene id: 858215:THEXY_RS10750
uniprot id: F6BKQ0
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS07380
gene id: 858215:THEXY_RS07380
uniprot id: F6BGL5
names: Similarity
messages: Belongs to the IMPACT family.

858215:THEXY RS01715
gene id: 858215:THEXY_RS01715
uniprot id: F6BGG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

858215:THEXY RS12145
gene id: 858215:THEXY_RS12145
uniprot id: F6BG90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

858215:THEXY RS08485
gene id: 858215:THEXY_RS08485
uniprot id: F6BI20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS05580
gene id: 858215:THEXY_RS05580
uniprot id: F6BKI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

858215:THEXY RS08640
gene id: 858215:THEXY_RS08640
uniprot id: F6BI49
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Amj family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS01530
gene id: 858215:THEXY_RS01530
uniprot id: F6BGD1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

858215:THEXY RS06290
gene id: 858215:THEXY_RS06290
uniprot id: F6BLL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

858215:THEXY RS03775
gene id: 858215:THEXY_RS03775
uniprot id: F6BIN6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

858215:THEXY RS00640
gene id: 858215:THEXY_RS00640
uniprot id: F6BFA1
names: Similarity
messages: Belongs to the HypD family.

858215:THEXY RS02945
gene id: 858215:THEXY_RS02945
uniprot id: F6BHU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

858215:THEXY RS09280
gene id: 858215:THEXY_RS09280
uniprot id: F6BIW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

858215:THEXY RS11080
gene id: 858215:THEXY_RS11080
uniprot id: F6BL67
names: Similarity
messages: Belongs to the LacAB/RpiB family.

858215:THEXY RS06090
gene id: 858215:THEXY_RS06090
uniprot id: F6BL34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

858215:THEXY RS08725
gene id: 858215:THEXY_RS08725
uniprot id: F6BI66
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

858215:THEXY RS07910
gene id: 858215:THEXY_RS07910
uniprot id: F6BHA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

858215:THEXY RS00625
gene id: 858215:THEXY_RS00625
uniprot id: F6BF98
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

858215:THEXY RS00485
gene id: 858215:THEXY_RS00485
uniprot id: F6BLH2
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS01300
gene id: 858215:THEXY_RS01300
uniprot id: F6BG12
names: Similarity
messages: Belongs to the UPF0237 family.

858215:THEXY RS03025
gene id: 858215:THEXY_RS03025
uniprot id: F6BHW0
names: Similarity
messages: Belongs to the transpeptidase family.

858215:THEXY RS07120
gene id: 858215:THEXY_RS07120
uniprot id: F6BG82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

858215:THEXY RS04625
gene id: 858215:THEXY_RS04625
uniprot id: F6BJG1
names: Similarity
messages: Belongs to the DsrF/TusC family.

858215:THEXY RS06415
gene id: 858215:THEXY_RS06415
uniprot id: F6BLN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

858215:THEXY RS09265
gene id: 858215:THEXY_RS09265
uniprot id: F6BIV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

858215:THEXY RS08425
gene id: 858215:THEXY_RS08425
uniprot id: F6BHT3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

858215:THEXY RS08710
gene id: 858215:THEXY_RS08710
uniprot id: F6BI63
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS05170
gene id: 858215:THEXY_RS05170
uniprot id: F6BI89
names: Similarity
messages: Belongs to the UPF0236 family.

858215:THEXY RS05190
gene id: 858215:THEXY_RS05190
uniprot id: F6BK43
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

858215:THEXY RS05220
gene id: 858215:THEXY_RS05220
uniprot id: F6BK49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS06895
gene id: 858215:THEXY_RS06895
uniprot id: F6BG36
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

858215:THEXY RS02005
gene id: 858215:THEXY_RS02005
uniprot id: F6BGS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

858215:THEXY RS05450
gene id: 858215:THEXY_RS05450
uniprot id: F6BK94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

858215:THEXY RS03750
gene id: 858215:THEXY_RS03750
uniprot id: F6BIN1
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

858215:THEXY RS11120
gene id: 858215:THEXY_RS11120
uniprot id: F6BL75
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

858215:THEXY RS04645
gene id: 858215:THEXY_RS04645
uniprot id: F6BJG5
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS05120
gene id: 858215:THEXY_RS05120
uniprot id: F6BJW7
names: Similarity
messages: Belongs to the EamA transporter family.

858215:THEXY RS08835
gene id: 858215:THEXY_RS08835
uniprot id: F6BIG2
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS02350
gene id: 858215:THEXY_RS02350
uniprot id: F6BH50
names: Similarity
messages: Belongs to the band 7/mec-2 family.

858215:THEXY RS06985
gene id: 858215:THEXY_RS06985
uniprot id: F6BG54
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

858215:THEXY RS02460
gene id: 858215:THEXY_RS02460
uniprot id: F6BH72
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS10930
gene id: 858215:THEXY_RS10930
uniprot id: F6BKT6
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

858215:THEXY RS00510
gene id: 858215:THEXY_RS00510
uniprot id: F6BLH7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS07070
gene id: 858215:THEXY_RS07070
uniprot id: F6BG72
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

858215:THEXY RS09140
gene id: 858215:THEXY_RS09140
uniprot id: F6BIT5
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS03680
gene id: 858215:THEXY_RS03680
uniprot id: F6BIL7
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

858215:THEXY RS04460
gene id: 858215:THEXY_RS04460
uniprot id: F6BJC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

858215:THEXY RS04340
gene id: 858215:THEXY_RS04340
uniprot id: F6BJ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

858215:THEXY RS10695
gene id: 858215:THEXY_RS10695
uniprot id: F6BKN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS01100
gene id: 858215:THEXY_RS01100
uniprot id: F6BFX6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS07695
gene id: 858215:THEXY_RS07695
uniprot id: F6BGZ1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

858215:THEXY RS01650
gene id: 858215:THEXY_RS01650
uniprot id: F6BGF5
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival.

858215:THEXY RS08840
gene id: 858215:THEXY_RS08840
uniprot id: F6BIG3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS02380
gene id: 858215:THEXY_RS02380
uniprot id: F6BH56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

858215:THEXY RS06775
gene id: 858215:THEXY_RS06775
uniprot id: F6BFL8
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

858215:THEXY RS01125
gene id: 858215:THEXY_RS01125
uniprot id: F6BFY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS06640
gene id: 858215:THEXY_RS06640
uniprot id: F6BFJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

858215:THEXY RS07825
gene id: 858215:THEXY_RS07825
uniprot id: F6BH91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS10235
gene id: 858215:THEXY_RS10235
uniprot id: F6BK13
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

858215:THEXY RS11250
gene id: 858215:THEXY_RS11250
uniprot id: F6BL98
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

858215:THEXY RS11460
gene id: 858215:THEXY_RS11460
uniprot id: F6BLS3
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS10860
gene id: 858215:THEXY_RS10860
uniprot id: F6BKS2
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

858215:THEXY RS06645
gene id: 858215:THEXY_RS06645
uniprot id: F6BFJ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

858215:THEXY RS05525
gene id: 858215:THEXY_RS05525
uniprot id: F6BKA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U4 family.
messages: Cell membrane
messages: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.

858215:THEXY RS05285
gene id: 858215:THEXY_RS05285
uniprot id: F6BK63
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

858215:THEXY RS03530
gene id: 858215:THEXY_RS03530
uniprot id: F6BIC1
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

858215:THEXY RS09775
gene id: 858215:THEXY_RS09775
uniprot id: F6BJJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS05075
gene id: 858215:THEXY_RS05075
uniprot id: F6BJV8
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS00790
gene id: 858215:THEXY_RS00790
uniprot id: F6BFC8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS05625
gene id: 858215:THEXY_RS05625
uniprot id: F6BKJ2
names: Function
names: Subcellular Location Annotation
messages: ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
messages: Cytoplasm

858215:THEXY RS00925
gene id: 858215:THEXY_RS00925
uniprot id: F6BFF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

858215:THEXY RS11690
gene id: 858215:THEXY_RS11690
uniprot id: F6BLW8
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

858215:THEXY RS12045
gene id: 858215:THEXY_RS12045
uniprot id: F6BFT2
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

858215:THEXY RS01700
gene id: 858215:THEXY_RS01700
uniprot id: F6BGG5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

858215:THEXY RS08415
gene id: 858215:THEXY_RS08415
uniprot id: F6BHT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: Membrane

858215:THEXY RS01485
gene id: 858215:THEXY_RS01485
uniprot id: F6BGC1
names: Similarity
messages: Belongs to the SfsA family.

858215:THEXY RS06410
gene id: 858215:THEXY_RS06410
uniprot id: F6BLN6
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

858215:THEXY RS01735
gene id: 858215:THEXY_RS01735
uniprot id: F6BGN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

858215:THEXY RS04160
gene id: 858215:THEXY_RS04160
uniprot id: F6BJ14
names: Similarity
messages: Belongs to the peptidase S16 family.

858215:THEXY RS01875
gene id: 858215:THEXY_RS01875
uniprot id: F6BGR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

858215:THEXY RS11970
gene id: 858215:THEXY_RS11970
uniprot id: F6BFR7
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

858215:THEXY RS10285
gene id: 858215:THEXY_RS10285
uniprot id: F6BK23
names: Similarity
messages: Belongs to the glycosyl hydrolase.

858215:THEXY RS11040
gene id: 858215:THEXY_RS11040
uniprot id: F6BL59
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS06835
gene id: 858215:THEXY_RS06835
uniprot id: F6BG24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

858215:THEXY RS02975
gene id: 858215:THEXY_RS02975
uniprot id: F6BHV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

858215:THEXY RS11385
gene id: 858215:THEXY_RS11385
uniprot id: F6BLQ8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

858215:THEXY RS07570
gene id: 858215:THEXY_RS07570
uniprot id: F6BGW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

858215:THEXY RS05420
gene id: 858215:THEXY_RS05420
uniprot id: F6BK88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

858215:THEXY RS02390
gene id: 858215:THEXY_RS02390
uniprot id: F6BH58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

858215:THEXY RS12135
gene id: 858215:THEXY_RS12135
uniprot id: F6BFV0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS01910
gene id: 858215:THEXY_RS01910
uniprot id: F6BGR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

858215:THEXY RS02745
gene id: 858215:THEXY_RS02745
uniprot id: F6BHJ1
names: Similarity
messages: Belongs to the ComB family.

858215:THEXY RS02220
gene id: 858215:THEXY_RS02220
uniprot id: F6BH30
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

858215:THEXY RS06820
gene id: 858215:THEXY_RS06820
uniprot id: F6BFM7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

858215:THEXY RS10395
gene id: 858215:THEXY_RS10395
uniprot id: F6BKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS08580
gene id: 858215:THEXY_RS08580
uniprot id: F6BI39
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

858215:THEXY RS04990
gene id: 858215:THEXY_RS04990
uniprot id: F6BJU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

858215:THEXY RS07335
gene id: 858215:THEXY_RS07335
uniprot id: F6BGK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

858215:THEXY RS09610
gene id: 858215:THEXY_RS09610
uniprot id: F6BJ94
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

858215:THEXY RS09415
gene id: 858215:THEXY_RS09415
uniprot id: F6BJ55
names: Similarity
messages: Belongs to the helicase family. RAD3/XPD subfamily.

858215:THEXY RS03015
gene id: 858215:THEXY_RS03015
uniprot id: F6BHV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

858215:THEXY RS09355
gene id: 858215:THEXY_RS09355
uniprot id: F6BIX6
names: Similarity
messages: Belongs to the manganese catalase family.

858215:THEXY RS06740
gene id: 858215:THEXY_RS06740
uniprot id: F6BFL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

858215:THEXY RS01685
gene id: 858215:THEXY_RS01685
uniprot id: F6BGG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

858215:THEXY RS06660
gene id: 858215:THEXY_RS06660
uniprot id: F6BFJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

858215:THEXY RS03715
gene id: 858215:THEXY_RS03715
uniprot id: F6BIM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

858215:THEXY RS03120
gene id: 858215:THEXY_RS03120
uniprot id: F6BHX9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

858215:THEXY RS00390
gene id: 858215:THEXY_RS00390
uniprot id: F6BLF5
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

858215:THEXY RS07715
gene id: 858215:THEXY_RS07715
uniprot id: F6BGZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

858215:THEXY RS02880
gene id: 858215:THEXY_RS02880
uniprot id: F6BHL9
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 51 family.
messages: Homohexamer; trimer of dimers.

858215:THEXY RS12080
gene id: 858215:THEXY_RS12080
uniprot id: F6BFT9
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

858215:THEXY RS07280
gene id: 858215:THEXY_RS07280
uniprot id: F6BGJ4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

858215:THEXY RS07330
gene id: 858215:THEXY_RS07330
uniprot id: F6BGK5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

858215:THEXY RS00015
gene id: 858215:THEXY_RS00015
uniprot id: F6BKV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

858215:THEXY RS11355
gene id: 858215:THEXY_RS11355
uniprot id: F6BLC0
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

858215:THEXY RS02615
gene id: 858215:THEXY_RS02615
uniprot id: F6BHG6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS06085
gene id: 858215:THEXY_RS06085
uniprot id: F6BL33
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

858215:THEXY RS05885
gene id: 858215:THEXY_RS05885
uniprot id: F6BKZ3
names: Similarity
messages: Belongs to the UPF0473 family.

858215:THEXY RS09805
gene id: 858215:THEXY_RS09805
uniprot id: F6BJK2
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS06680
gene id: 858215:THEXY_RS06680
uniprot id: F6BFJ9
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

858215:THEXY RS00775
gene id: 858215:THEXY_RS00775
uniprot id: F6BFC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

858215:THEXY RS09620
gene id: 858215:THEXY_RS09620
uniprot id: F6BJ96
names: Similarity
messages: Belongs to the FlgM family.

858215:THEXY RS11265
gene id: 858215:THEXY_RS11265
uniprot id: F6BLA1
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS11895
gene id: 858215:THEXY_RS11895
uniprot id: F6BFQ5
names: Similarity
messages: Belongs to the UPF0236 family.

858215:THEXY RS10865
gene id: 858215:THEXY_RS10865
uniprot id: F6BKS3
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

858215:THEXY RS03495
gene id: 858215:THEXY_RS03495
uniprot id: F6BIB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

858215:THEXY RS04120
gene id: 858215:THEXY_RS04120
uniprot id: F6BJ06
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS07590
gene id: 858215:THEXY_RS07590
uniprot id: F6BGX1
names: Similarity
messages: Belongs to the glutamine synthetase family.

858215:THEXY RS11420
gene id: 858215:THEXY_RS11420
uniprot id: F6BLR5
names: Similarity
messages: Belongs to the UPF0735 family.

858215:THEXY RS07605
gene id: 858215:THEXY_RS07605
uniprot id: F6BGX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

858215:THEXY RS08030
gene id: 858215:THEXY_RS08030
uniprot id: F6BHD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

858215:THEXY RS06750
gene id: 858215:THEXY_RS06750
uniprot id: F6BFL3
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS00635
gene id: 858215:THEXY_RS00635
uniprot id: F6BFA0
names: Similarity
messages: Belongs to the HupF/HypC family.

858215:THEXY RS02430
gene id: 858215:THEXY_RS02430
uniprot id: F6BH66
names: Similarity
messages: Belongs to the phosphohexose mutase family.

858215:THEXY RS05880
gene id: 858215:THEXY_RS05880
uniprot id: F6BKZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

858215:THEXY RS04865
gene id: 858215:THEXY_RS04865
uniprot id: F6BJR9
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

858215:THEXY RS01540
gene id: 858215:THEXY_RS01540
uniprot id: F6BGD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

858215:THEXY RS00100
gene id: 858215:THEXY_RS00100
uniprot id: F6BKW9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

858215:THEXY RS11140
gene id: 858215:THEXY_RS11140
uniprot id: F6BL79
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS05960
gene id: 858215:THEXY_RS05960
uniprot id: F6BL08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

858215:THEXY RS04410
gene id: 858215:THEXY_RS04410
uniprot id: F6BJB8
names: Similarity
messages: Belongs to the peptidase M24B family.

858215:THEXY RS03390
gene id: 858215:THEXY_RS03390
uniprot id: F6BI93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

858215:THEXY RS00120
gene id: 858215:THEXY_RS00120
uniprot id: F6BKX3
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

858215:THEXY RS08490
gene id: 858215:THEXY_RS08490
uniprot id: F6BI21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS06560
gene id: 858215:THEXY_RS06560
uniprot id: F6BFH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

858215:THEXY RS03315
gene id: 858215:THEXY_RS03315
uniprot id: F6BI81
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

858215:THEXY RS08915
gene id: 858215:THEXY_RS08915
uniprot id: F6BIH8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

858215:THEXY RS06635
gene id: 858215:THEXY_RS06635
uniprot id: F6BFI9
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS10585
gene id: 858215:THEXY_RS10585
uniprot id: F6BKF2
names: Function
names: Similarity
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

858215:THEXY RS04610
gene id: 858215:THEXY_RS04610
uniprot id: F6BJF8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

858215:THEXY RS00080
gene id: 858215:THEXY_RS00080
uniprot id: F6BKW5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

858215:THEXY RS04050
gene id: 858215:THEXY_RS04050
uniprot id: F6BIZ1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

858215:THEXY RS03580
gene id: 858215:THEXY_RS03580
uniprot id: F6BID0
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS06350
gene id: 858215:THEXY_RS06350
uniprot id: F6BLM4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

858215:THEXY RS11295
gene id: 858215:THEXY_RS11295
uniprot id: F6BLA7
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS07745
gene id: 858215:THEXY_RS07745
uniprot id: F6BH01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

858215:THEXY RS07535
gene id: 858215:THEXY_RS07535
uniprot id: F6BGW0
names: Similarity
messages: Belongs to the UPF0045 family.

858215:THEXY RS01580
gene id: 858215:THEXY_RS01580
uniprot id: F6BGE1
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

858215:THEXY RS05790
gene id: 858215:THEXY_RS05790
uniprot id: F6BKM5
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS04425
gene id: 858215:THEXY_RS04425
uniprot id: F6BJC1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

858215:THEXY RS06145
gene id: 858215:THEXY_RS06145
uniprot id: F6BL45
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS05835
gene id: 858215:THEXY_RS05835
uniprot id: F6BKN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS08270
gene id: 858215:THEXY_RS08270
uniprot id: F6BHQ2
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

858215:THEXY RS07510
gene id: 858215:THEXY_RS07510
uniprot id: F6BGV5
names: Similarity
messages: Belongs to the TrpC family.

858215:THEXY RS03645
gene id: 858215:THEXY_RS03645
uniprot id: F6BIL0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

858215:THEXY RS03830
gene id: 858215:THEXY_RS03830
uniprot id: F6BIP7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

858215:THEXY RS04935
gene id: 858215:THEXY_RS04935
uniprot id: F6BJT3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

858215:THEXY RS11860
gene id: 858215:THEXY_RS11860
uniprot id: F6BFP9
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

858215:THEXY RS03820
gene id: 858215:THEXY_RS03820
uniprot id: F6BIP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

858215:THEXY RS03595
gene id: 858215:THEXY_RS03595
uniprot id: F6BID3
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS00460
gene id: 858215:THEXY_RS00460
uniprot id: F6BLG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS06200
gene id: 858215:THEXY_RS06200
uniprot id: F6BLJ3
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.
messages: In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.

858215:THEXY RS07005
gene id: 858215:THEXY_RS07005
uniprot id: F6BG58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS09855
gene id: 858215:THEXY_RS09855
uniprot id: F6BJL2
names: Similarity
messages: Belongs to the BMP lipoprotein family.

858215:THEXY RS04010
gene id: 858215:THEXY_RS04010
uniprot id: F6BIS0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

858215:THEXY RS01890
gene id: 858215:THEXY_RS01890
uniprot id: F6BGR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

858215:THEXY RS10065
gene id: 858215:THEXY_RS10065
uniprot id: F6BJY1
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

858215:THEXY RS06815
gene id: 858215:THEXY_RS06815
uniprot id: F6BFM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

858215:THEXY RS02705
gene id: 858215:THEXY_RS02705
uniprot id: F6BHI3
names: Similarity
messages: Belongs to the glutamate synthase family.

858215:THEXY RS09820
gene id: 858215:THEXY_RS09820
uniprot id: F6BJK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

858215:THEXY RS09275
gene id: 858215:THEXY_RS09275
uniprot id: F6BIW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

858215:THEXY RS01635
gene id: 858215:THEXY_RS01635
uniprot id: F6BGF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

858215:THEXY RS01780
gene id: 858215:THEXY_RS01780
uniprot id: F6BGP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

858215:THEXY RS11840
gene id: 858215:THEXY_RS11840
uniprot id: F6BFP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

858215:THEXY RS01840
gene id: 858215:THEXY_RS01840
uniprot id: F6BGQ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

858215:THEXY RS08895
gene id: 858215:THEXY_RS08895
uniprot id: F6BIH4
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

858215:THEXY RS08390
gene id: 858215:THEXY_RS08390
uniprot id: F6BHS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

858215:THEXY RS05895
gene id: 858215:THEXY_RS05895
uniprot id: F6BKZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

858215:THEXY RS09155
gene id: 858215:THEXY_RS09155
uniprot id: F6BIT8
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

858215:THEXY RS01365
gene id: 858215:THEXY_RS01365
uniprot id: F6BG96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

858215:THEXY RS06525
gene id: 858215:THEXY_RS06525
uniprot id: F6BFG7
names: Similarity
messages: Belongs to the peptidase S14 family.

858215:THEXY RS05810
gene id: 858215:THEXY_RS05810
uniprot id: F6BKM9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS09705
gene id: 858215:THEXY_RS09705
uniprot id: F6BJB0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

858215:THEXY RS01080
gene id: 858215:THEXY_RS01080
uniprot id: F6BFX2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

858215:THEXY RS10170
gene id: 858215:THEXY_RS10170
uniprot id: F6BK01
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS11285
gene id: 858215:THEXY_RS11285
uniprot id: F6BLA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

858215:THEXY RS06755
gene id: 858215:THEXY_RS06755
uniprot id: F6BFL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

858215:THEXY RS05485
gene id: 858215:THEXY_RS05485
uniprot id: F6BKA1
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS07555
gene id: 858215:THEXY_RS07555
uniprot id: F6BGW4
names: Subcellular Location Annotation
messages: Cytoplasm

858215:THEXY RS02240
gene id: 858215:THEXY_RS02240
uniprot id: F6BH34
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

858215:THEXY RS12105
gene id: 858215:THEXY_RS12105
uniprot id: F6BFU4
names: Similarity
messages: Belongs to the ParB family.

858215:THEXY RS09830
gene id: 858215:THEXY_RS09830
uniprot id: F6BJK7
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

858215:THEXY RS04570
gene id: 858215:THEXY_RS04570
uniprot id: F6BJF1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

858215:THEXY RS00365
gene id: 858215:THEXY_RS00365
uniprot id: F6BLF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

858215:THEXY RS05350
gene id: 858215:THEXY_RS05350
uniprot id: F6BK74
names: Similarity
messages: Belongs to the peptidase M18 family.

858215:THEXY RS07410
gene id: 858215:THEXY_RS07410
uniprot id: F6BGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

858215:THEXY RS10710
gene id: 858215:THEXY_RS10710
uniprot id: F6BKP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

858215:THEXY RS10600
gene id: 858215:THEXY_RS10600
uniprot id: F6BKF5
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

858215:THEXY RS10020
gene id: 858215:THEXY_RS10020
uniprot id: F6BJP6
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS06100
gene id: 858215:THEXY_RS06100
uniprot id: F6BL36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

858215:THEXY RS05865
gene id: 858215:THEXY_RS05865
uniprot id: F6BKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

858215:THEXY RS01630
gene id: 858215:THEXY_RS01630
uniprot id: F6BGF1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

858215:THEXY RS00595
gene id: 858215:THEXY_RS00595
uniprot id: F6BF92
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS06795
gene id: 858215:THEXY_RS06795
uniprot id: F6BFM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS10940
gene id: 858215:THEXY_RS10940
uniprot id: F6BKT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

858215:THEXY RS11475
gene id: 858215:THEXY_RS11475
uniprot id: F6BLS6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

858215:THEXY RS00760
gene id: 858215:THEXY_RS00760
uniprot id: F6BFC2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

858215:THEXY RS01465
gene id: 858215:THEXY_RS01465
uniprot id: F6BGB7
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

858215:THEXY RS02750
gene id: 858215:THEXY_RS02750
uniprot id: F6BHJ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

858215:THEXY RS04225
gene id: 858215:THEXY_RS04225
uniprot id: F6BJ27
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

858215:THEXY RS00855
gene id: 858215:THEXY_RS00855
uniprot id: F6BFE1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

858215:THEXY RS06720
gene id: 858215:THEXY_RS06720
uniprot id: F6BFK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

858215:THEXY RS05890
gene id: 858215:THEXY_RS05890
uniprot id: F6BKZ4
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

858215:THEXY RS07140
gene id: 858215:THEXY_RS07140
uniprot id: F6BG86
names: Similarity
messages: Belongs to the RemA family.

858215:THEXY RS04375
gene id: 858215:THEXY_RS04375
uniprot id: F6BJ52
names: Subcellular Location Annotation
messages: Cytoplasm

858215:THEXY RS07530
gene id: 858215:THEXY_RS07530
uniprot id: F6BGV9
names: Similarity
messages: Belongs to the UPF0236 family.

858215:THEXY RS03220
gene id: 858215:THEXY_RS03220
uniprot id: F6BI01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

858215:THEXY RS11340
gene id: 858215:THEXY_RS11340
uniprot id: F6BLB7
names: Similarity
messages: Belongs to the HepT RNase toxin family.

858215:THEXY RS02525
gene id: 858215:THEXY_RS02525
uniprot id: F6BHE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS03455
gene id: 858215:THEXY_RS03455
uniprot id: F6BIA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

858215:THEXY RS06265
gene id: 858215:THEXY_RS06265
uniprot id: F6BLK7
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

858215:THEXY RS01295
gene id: 858215:THEXY_RS01295
uniprot id: F6BG11
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

858215:THEXY RS08440
gene id: 858215:THEXY_RS08440
uniprot id: F6BI11
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS06975
gene id: 858215:THEXY_RS06975
uniprot id: F6BG52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

858215:THEXY RS09190
gene id: 858215:THEXY_RS09190
uniprot id: F6BIU3
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

858215:THEXY RS01815
gene id: 858215:THEXY_RS01815
uniprot id: F6BGP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

858215:THEXY RS03200
gene id: 858215:THEXY_RS03200
uniprot id: F6BHZ7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

858215:THEXY RS01745
gene id: 858215:THEXY_RS01745
uniprot id: F6BGN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

858215:THEXY RS00930
gene id: 858215:THEXY_RS00930
uniprot id: F6BFF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

858215:THEXY RS04525
gene id: 858215:THEXY_RS04525
uniprot id: F6BJE1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

858215:THEXY RS04900
gene id: 858215:THEXY_RS04900
uniprot id: F6BJS6
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

858215:THEXY RS05715
gene id: 858215:THEXY_RS05715
uniprot id: F6BKK9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

858215:THEXY RS11165
gene id: 858215:THEXY_RS11165
uniprot id: F6BL84
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

858215:THEXY RS08540
gene id: 858215:THEXY_RS08540
uniprot id: F6BI32
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

858215:THEXY RS03550
gene id: 858215:THEXY_RS03550
uniprot id: F6BIC4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS01855
gene id: 858215:THEXY_RS01855
uniprot id: F6BGQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

858215:THEXY RS11060
gene id: 858215:THEXY_RS11060
uniprot id: F6BL63
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

858215:THEXY RS04025
gene id: 858215:THEXY_RS04025
uniprot id: F6BIY5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

858215:THEXY RS03710
gene id: 858215:THEXY_RS03710
uniprot id: F6BIM3
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS09935
gene id: 858215:THEXY_RS09935
uniprot id: F6BJM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

858215:THEXY RS01000
gene id: 858215:THEXY_RS01000
uniprot id: F6BFV7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

858215:THEXY RS02425
gene id: 858215:THEXY_RS02425
uniprot id: F6BH65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS01360
gene id: 858215:THEXY_RS01360
uniprot id: F6BG95
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

858215:THEXY RS09410
gene id: 858215:THEXY_RS09410
uniprot id: F6BJ54
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.

858215:THEXY RS08510
gene id: 858215:THEXY_RS08510
uniprot id: F6BI25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS06395
gene id: 858215:THEXY_RS06395
uniprot id: F6BLN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

858215:THEXY RS04250
gene id: 858215:THEXY_RS04250
uniprot id: F6BJ32
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

858215:THEXY RS06665
gene id: 858215:THEXY_RS06665
uniprot id: F6BFJ6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

858215:THEXY RS04195
gene id: 858215:THEXY_RS04195
uniprot id: F6BJ21
names: Similarity
messages: Belongs to the sigma-54 factor family.

858215:THEXY RS06080
gene id: 858215:THEXY_RS06080
uniprot id: F6BL32
names: Similarity
messages: Belongs to the asp23 family.

858215:THEXY RS00355
gene id: 858215:THEXY_RS00355
uniprot id: F6BLE8
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

858215:THEXY RS05230
gene id: 858215:THEXY_RS05230
uniprot id: F6BK51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

858215:THEXY RS04840
gene id: 858215:THEXY_RS04840
uniprot id: F6BJR4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

858215:THEXY RS10870
gene id: 858215:THEXY_RS10870
uniprot id: F6BKS4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

858215:THEXY RS08160
gene id: 858215:THEXY_RS08160
uniprot id: F6BHM9
names: Similarity
messages: Belongs to the transglycosylase Slt family.

858215:THEXY RS03515
gene id: 858215:THEXY_RS03515
uniprot id: F6BIB8
names: Similarity
messages: Belongs to the asp23 family.

858215:THEXY RS04370
gene id: 858215:THEXY_RS04370
uniprot id: F6BJ51
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

858215:THEXY RS06115
gene id: 858215:THEXY_RS06115
uniprot id: F6BL39
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

858215:THEXY RS04810
gene id: 858215:THEXY_RS04810
uniprot id: F6BJQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

858215:THEXY RS06385
gene id: 858215:THEXY_RS06385
uniprot id: F6BLN1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

858215:THEXY RS08790
gene id: 858215:THEXY_RS08790
uniprot id: F6BIF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS08795
gene id: 858215:THEXY_RS08795
uniprot id: F6BIF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS07500
gene id: 858215:THEXY_RS07500
uniprot id: F6BGV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

858215:THEXY RS04430
gene id: 858215:THEXY_RS04430
uniprot id: F6BJC2
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS09845
gene id: 858215:THEXY_RS09845
uniprot id: F6BJL0
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS01470
gene id: 858215:THEXY_RS01470
uniprot id: F6BGB8
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

858215:THEXY RS06970
gene id: 858215:THEXY_RS06970
uniprot id: F6BG51
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

858215:THEXY RS07255
gene id: 858215:THEXY_RS07255
uniprot id: F6BGI9
names: Similarity
messages: Belongs to the RecJ family.

858215:THEXY RS01570
gene id: 858215:THEXY_RS01570
uniprot id: F6BGD9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Catalyzes the specific phosphorylation of arginine residues in proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS05125
gene id: 858215:THEXY_RS05125
uniprot id: F6BJW8
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS08850
gene id: 858215:THEXY_RS08850
uniprot id: F6BIG5
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

858215:THEXY RS01480
gene id: 858215:THEXY_RS01480
uniprot id: F6BGC0
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

858215:THEXY RS02415
gene id: 858215:THEXY_RS02415
uniprot id: F6BH63
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS00025
gene id: 858215:THEXY_RS00025
uniprot id: F6BKV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

858215:THEXY RS09960
gene id: 858215:THEXY_RS09960
uniprot id: F6BJN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

858215:THEXY RS07245
gene id: 858215:THEXY_RS07245
uniprot id: F6BGI7
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

858215:THEXY RS09255
gene id: 858215:THEXY_RS09255
uniprot id: F6BIV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

858215:THEXY RS11390
gene id: 858215:THEXY_RS11390
uniprot id: F6BLQ9
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

858215:THEXY RS02850
gene id: 858215:THEXY_RS02850
uniprot id: F6BHL3
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

858215:THEXY RS01545
gene id: 858215:THEXY_RS01545
uniprot id: F6BGD4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

858215:THEXY RS08075
gene id: 858215:THEXY_RS08075
uniprot id: F6BHD9
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

858215:THEXY RS05945
gene id: 858215:THEXY_RS05945
uniprot id: F6BL05
names: Similarity
messages: Belongs to the GSP E family.

858215:THEXY RS06780
gene id: 858215:THEXY_RS06780
uniprot id: F6BFL9
names: Similarity
messages: Belongs to the FlgD family.

858215:THEXY RS02715
gene id: 858215:THEXY_RS02715
uniprot id: F6BHI5
names: Similarity
messages: Belongs to the CdaR family.

858215:THEXY RS01790
gene id: 858215:THEXY_RS01790
uniprot id: F6BGP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

858215:THEXY RS10120
gene id: 858215:THEXY_RS10120
uniprot id: F6BJZ1
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

858215:THEXY RS10375
gene id: 858215:THEXY_RS10375
uniprot id: F6BKB4
names: Similarity
messages: Belongs to the UxaA family.

858215:THEXY RS02280
gene id: 858215:THEXY_RS02280
uniprot id: F6BH38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

858215:THEXY RS10290
gene id: 858215:THEXY_RS10290
uniprot id: F6BK24
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

858215:THEXY RS00940
gene id: 858215:THEXY_RS00940
uniprot id: F6BFF8
names: Similarity
messages: Belongs to the carbamate kinase family.

858215:THEXY RS03175
gene id: 858215:THEXY_RS03175
uniprot id: F6BHZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

858215:THEXY RS05855
gene id: 858215:THEXY_RS05855
uniprot id: F6BKY6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

858215:THEXY RS04190
gene id: 858215:THEXY_RS04190
uniprot id: F6BJ20
names: Similarity
messages: Belongs to the acylphosphatase family.

858215:THEXY RS12095
gene id: 858215:THEXY_RS12095
uniprot id: F6BFU2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

858215:THEXY RS11685
gene id: 858215:THEXY_RS11685
uniprot id: F6BLW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

858215:THEXY RS02085
gene id: 858215:THEXY_RS02085
uniprot id: F6BGU1
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

858215:THEXY RS03210
gene id: 858215:THEXY_RS03210
uniprot id: F6BHZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS02875
gene id: 858215:THEXY_RS02875
uniprot id: F6BHL8
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

858215:THEXY RS06955
gene id: 858215:THEXY_RS06955
uniprot id: F6BG48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

858215:THEXY RS10155
gene id: 858215:THEXY_RS10155
uniprot id: F6BJZ8
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS06615
gene id: 858215:THEXY_RS06615
uniprot id: F6BFI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

858215:THEXY RS11505
gene id: 858215:THEXY_RS11505
uniprot id: F6BLT2
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

858215:THEXY RS09235
gene id: 858215:THEXY_RS09235
uniprot id: F6BIV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS05870
gene id: 858215:THEXY_RS05870
uniprot id: F6BKZ0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

858215:THEXY RS06380
gene id: 858215:THEXY_RS06380
uniprot id: F6BLN0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

858215:THEXY RS02370
gene id: 858215:THEXY_RS02370
uniprot id: F6BH54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

858215:THEXY RS03230
gene id: 858215:THEXY_RS03230
uniprot id: F6BI03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

858215:THEXY RS01845
gene id: 858215:THEXY_RS01845
uniprot id: F6BGQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

858215:THEXY RS10480
gene id: 858215:THEXY_RS10480
uniprot id: F6BKD5
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

858215:THEXY RS04880
gene id: 858215:THEXY_RS04880
uniprot id: F6BJS2
names: Similarity
messages: Belongs to the EamA transporter family.

858215:THEXY RS07635
gene id: 858215:THEXY_RS07635
uniprot id: F6BGX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

858215:THEXY RS07075
gene id: 858215:THEXY_RS07075
uniprot id: F6BG73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

858215:THEXY RS04040
gene id: 858215:THEXY_RS04040
uniprot id: F6BIY8
names: Similarity
messages: Belongs to the peptidase M29 family.

858215:THEXY RS04965
gene id: 858215:THEXY_RS04965
uniprot id: F6BJT9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

858215:THEXY RS05225
gene id: 858215:THEXY_RS05225
uniprot id: F6BK50
names: Similarity
messages: Belongs to the P(II) protein family.

858215:THEXY RS09105
gene id: 858215:THEXY_RS09105
uniprot id: F6BIT0
names: Similarity
messages: Belongs to the polysaccharide synthase family.

858215:THEXY RS01800
gene id: 858215:THEXY_RS01800
uniprot id: F6BGP6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

858215:THEXY RS11565
gene id: 858215:THEXY_RS11565
uniprot id: F6BLU4
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

858215:THEXY RS03420
gene id: 858215:THEXY_RS03420
uniprot id: F6BI99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

858215:THEXY RS09605
gene id: 858215:THEXY_RS09605
uniprot id: F6BJ93
names: Similarity
messages: Belongs to the bacterial flagellin family.

858215:THEXY RS08645
gene id: 858215:THEXY_RS08645
uniprot id: F6BI50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS03140
gene id: 858215:THEXY_RS03140
uniprot id: F6BHY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

858215:THEXY RS00810
gene id: 858215:THEXY_RS00810
uniprot id: F6BFD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Membrane

858215:THEXY RS07725
gene id: 858215:THEXY_RS07725
uniprot id: F6BGZ7
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

858215:THEXY RS07980
gene id: 858215:THEXY_RS07980
uniprot id: F6BHC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

858215:THEXY RS10595
gene id: 858215:THEXY_RS10595
uniprot id: F6BKF4
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

858215:THEXY RS05490
gene id: 858215:THEXY_RS05490
uniprot id: F6BKA2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS05875
gene id: 858215:THEXY_RS05875
uniprot id: F6BKZ1
names: Similarity
messages: Belongs to the UPF0297 family.

858215:THEXY RS08990
gene id: 858215:THEXY_RS08990
uniprot id: F6BIJ4
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS09270
gene id: 858215:THEXY_RS09270
uniprot id: F6BIV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

858215:THEXY RS10045
gene id: 858215:THEXY_RS10045
uniprot id: F6BJX6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

858215:THEXY RS04855
gene id: 858215:THEXY_RS04855
uniprot id: F6BJR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

858215:THEXY RS07395
gene id: 858215:THEXY_RS07395
uniprot id: F6BGL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

858215:THEXY RS06905
gene id: 858215:THEXY_RS06905
uniprot id: F6BG38
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

858215:THEXY RS09945
gene id: 858215:THEXY_RS09945
uniprot id: F6BJN0
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

858215:THEXY RS05690
gene id: 858215:THEXY_RS05690
uniprot id: F6BKK4
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS03585
gene id: 858215:THEXY_RS03585
uniprot id: F6BID1
names: Similarity
messages: Belongs to the leucine-binding protein family.

858215:THEXY RS03380
gene id: 858215:THEXY_RS03380
uniprot id: F6BI91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS08445
gene id: 858215:THEXY_RS08445
uniprot id: F6BI12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

858215:THEXY RS07470
gene id: 858215:THEXY_RS07470
uniprot id: F6BGN2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

858215:THEXY RS02735
gene id: 858215:THEXY_RS02735
uniprot id: F6BHI9
names: Similarity
messages: Belongs to the peptidase S41A family.

858215:THEXY RS08450
gene id: 858215:THEXY_RS08450
uniprot id: F6BI13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

858215:THEXY RS10165
gene id: 858215:THEXY_RS10165
uniprot id: F6BK00
names: Similarity
messages: Belongs to the Tlp family.

858215:THEXY RS06295
gene id: 858215:THEXY_RS06295
uniprot id: F6BLL3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

858215:THEXY RS06890
gene id: 858215:THEXY_RS06890
uniprot id: F6BG35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

858215:THEXY RS06020
gene id: 858215:THEXY_RS06020
uniprot id: F6BL20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

858215:THEXY RS05375
gene id: 858215:THEXY_RS05375
uniprot id: F0DSR4
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

858215:THEXY RS02165
gene id: 858215:THEXY_RS02165
uniprot id: F6BH19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the hemerythrin family.
messages: Monomer.
messages: Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen-binding site contains two iron atoms.

858215:THEXY RS11975
gene id: 858215:THEXY_RS11975
uniprot id: F6BFR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

858215:THEXY RS03285
gene id: 858215:THEXY_RS03285
uniprot id: F6BI75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

858215:THEXY RS09290
gene id: 858215:THEXY_RS09290
uniprot id: F6BIW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

858215:THEXY RS09590
gene id: 858215:THEXY_RS09590
uniprot id: F6BJ90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

858215:THEXY RS02045
gene id: 858215:THEXY_RS02045
uniprot id: F6BGT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Probably a homodimer.

858215:THEXY RS04220
gene id: 858215:THEXY_RS04220
uniprot id: F6BJ26
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

858215:THEXY RS02270
gene id: 858215:THEXY_RS02270
uniprot id: F6BGV9
names: Similarity
messages: Belongs to the UPF0236 family.

858215:THEXY RS09000
gene id: 858215:THEXY_RS09000
uniprot id: F6BIJ6
names: Similarity
messages: Belongs to the UPF0236 family.

858215:THEXY RS08275
gene id: 858215:THEXY_RS08275
uniprot id: F6BHQ3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

858215:THEXY RS02970
gene id: 858215:THEXY_RS02970
uniprot id: F6BHU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

858215:THEXY RS03150
gene id: 858215:THEXY_RS03150
uniprot id: F6BHY5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

858215:THEXY RS05560
gene id: 858215:THEXY_RS05560
uniprot id: F6BKH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

858215:THEXY RS03505
gene id: 858215:THEXY_RS03505
uniprot id: F6BIB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

858215:THEXY RS07205
gene id: 858215:THEXY_RS07205
uniprot id: F6BGH9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

858215:THEXY RS02185
gene id: 858215:THEXY_RS02185
uniprot id: F6BH23
names: Similarity
messages: Belongs to the UPF0047 family.

858215:THEXY RS06500
gene id: 858215:THEXY_RS06500
uniprot id: F6BLQ4
names: Similarity
messages: Belongs to the CinA family.

858215:THEXY RS07000
gene id: 858215:THEXY_RS07000
uniprot id: F6BG57
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

858215:THEXY RS05705
gene id: 858215:THEXY_RS05705
uniprot id: F6BKK7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

858215:THEXY RS03635
gene id: 858215:THEXY_RS03635
uniprot id: F6BIE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

858215:THEXY RS06545
gene id: 858215:THEXY_RS06545
uniprot id: F6BFH1
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

858215:THEXY RS04960
gene id: 858215:THEXY_RS04960
uniprot id: F6BJT8
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

858215:THEXY RS08750
gene id: 858215:THEXY_RS08750
uniprot id: F6BIE6
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

858215:THEXY RS00010
gene id: 858215:THEXY_RS00010
uniprot id: F6BKV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

858215:THEXY RS03460
gene id: 858215:THEXY_RS03460
uniprot id: F6BIA7
names: Similarity
messages: Belongs to the carbamate kinase family.

858215:THEXY RS04125
gene id: 858215:THEXY_RS04125
uniprot id: F6BJ07
names: Subcellular Location Annotation
messages: Cytoplasm

858215:THEXY RS02495
gene id: 858215:THEXY_RS02495
uniprot id: F6BH79
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

858215:THEXY RS07545
gene id: 858215:THEXY_RS07545
uniprot id: F6BGW2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

858215:THEXY RS08290
gene id: 858215:THEXY_RS08290
uniprot id: F6BHQ6
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

858215:THEXY RS03440
gene id: 858215:THEXY_RS03440
uniprot id: F6BIA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS06875
gene id: 858215:THEXY_RS06875
uniprot id: F6BG32
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

858215:THEXY RS05900
gene id: 858215:THEXY_RS05900
uniprot id: F6BKZ6
names: Similarity
messages: Belongs to the UPF0342 family.

858215:THEXY RS04945
gene id: 858215:THEXY_RS04945
uniprot id: F6BJT5
names: Similarity
messages: Belongs to the UxaA family.

858215:THEXY RS00980
gene id: 858215:THEXY_RS00980
uniprot id: F6BFV3
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS09970
gene id: 858215:THEXY_RS09970
uniprot id: F6BJN5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

858215:THEXY RS03705
gene id: 858215:THEXY_RS03705
uniprot id: F6BIM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

858215:THEXY RS03465
gene id: 858215:THEXY_RS03465
uniprot id: F6BIA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

858215:THEXY RS00115
gene id: 858215:THEXY_RS00115
uniprot id: F6BKX2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

858215:THEXY RS10520
gene id: 858215:THEXY_RS10520
uniprot id: F6BKE0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

858215:THEXY RS02275
gene id: 858215:THEXY_RS02275
uniprot id: F6BH37
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

858215:THEXY RS00075
gene id: 858215:THEXY_RS00075
uniprot id: F6BKW4
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

858215:THEXY RS06685
gene id: 858215:THEXY_RS06685
uniprot id: F6BFK0
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

858215:THEXY RS05505
gene id: 858215:THEXY_RS05505
uniprot id: F6BKA5
names: Similarity
messages: Belongs to the UPF0749 family.

858215:THEXY RS01660
gene id: 858215:THEXY_RS01660
uniprot id: F6BGF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

858215:THEXY RS11845
gene id: 858215:THEXY_RS11845
uniprot id: F6BFP6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

858215:THEXY RS07030
gene id: 858215:THEXY_RS07030
uniprot id: F6BG63
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

858215:THEXY RS02360
gene id: 858215:THEXY_RS02360
uniprot id: F6BH52
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

858215:THEXY RS10785
gene id: 858215:THEXY_RS10785
uniprot id: F6BKQ7
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

858215:THEXY RS06655
gene id: 858215:THEXY_RS06655
uniprot id: F6BFJ4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS10070
gene id: 858215:THEXY_RS10070
uniprot id: F6BJY2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

858215:THEXY RS09050
gene id: 858215:THEXY_RS09050
uniprot id: F6BIK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

858215:THEXY RS05460
gene id: 858215:THEXY_RS05460
uniprot id: F6BK96
names: Similarity
messages: Belongs to the transpeptidase family.

858215:THEXY RS10110
gene id: 858215:THEXY_RS10110
uniprot id: F6BJZ0
names: Similarity
messages: Belongs to the 5'-nucleotidase family.
messages: Belongs to the CapA family.

858215:THEXY RS07275
gene id: 858215:THEXY_RS07275
uniprot id: F6BGJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

858215:THEXY RS08170
gene id: 858215:THEXY_RS08170
uniprot id: F6BHN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

858215:THEXY RS07650
gene id: 858215:THEXY_RS07650
uniprot id: F6BGY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

858215:THEXY RS02580
gene id: 858215:THEXY_RS02580
uniprot id: F6BHF9
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

858215:THEXY RS01265
gene id: 858215:THEXY_RS01265
uniprot id: F6BG05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

858215:THEXY RS12575
gene id: 858215:THEXY_RS12575
uniprot id: F6BKB0
names: Function
names: Similarity
messages: Belongs to the UxaE family.
messages: Catalyzes the epimerization of D-tagaturonate (D-TagA) to D-fructuronate (D-FruA).

858215:THEXY RS03560
gene id: 858215:THEXY_RS03560
uniprot id: F6BIC6
names: Subcellular Location Annotation
messages: Cell membrane

858215:THEXY RS09650
gene id: 858215:THEXY_RS09650
uniprot id: F6BJA2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

858215:THEXY RS01760
gene id: 858215:THEXY_RS01760
uniprot id: F6BGN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

858215:THEXY RS00585
gene id: 858215:THEXY_RS00585
uniprot id: F6BF89
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: In the C-terminal section; belongs to the peptidase M41 family.

858215:THEXY RS00950
gene id: 858215:THEXY_RS00950
uniprot id: F6BFG0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

858215:THEXY RS03745
gene id: 858215:THEXY_RS03745
uniprot id: F6BIN0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

858215:THEXY RS04280
gene id: 858215:THEXY_RS04280
uniprot id: F6BJ36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS09900
gene id: 858215:THEXY_RS09900
uniprot id: F6BJM1
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS02485
gene id: 858215:THEXY_RS02485
uniprot id: F6BH77
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

858215:THEXY RS09310
gene id: 858215:THEXY_RS09310
uniprot id: F6BIW7
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

858215:THEXY RS03295
gene id: 858215:THEXY_RS03295
uniprot id: F6BI77
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

858215:THEXY RS07855
gene id: 858215:THEXY_RS07855
uniprot id: F6BH97
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

858215:THEXY RS09585
gene id: 858215:THEXY_RS09585
uniprot id: F6BJ89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

858215:THEXY RS08630
gene id: 858215:THEXY_RS08630
uniprot id: F6BI47
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

858215:THEXY RS04115
gene id: 858215:THEXY_RS04115
uniprot id: F6BJ05
names: Subcellular Location Annotation
messages: Membrane

858215:THEXY RS05940
gene id: 858215:THEXY_RS05940
uniprot id: F6BL04
names: Similarity
messages: Belongs to the GSP E family.

858215:THEXY RS06190
gene id: 858215:THEXY_RS06190
uniprot id: F6BLJ1
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

858215:THEXY RS06210
gene id: 858215:THEXY_RS06210
uniprot id: F6BLJ5
names: Similarity
messages: Belongs to the sigma-70 factor family.

858215:THEXY RS11660
gene id: 858215:THEXY_RS11660
uniprot id: F6BLW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SspH family.
messages: Spore core

858215:THEXY RS11710
gene id: 858215:THEXY_RS11710
uniprot id: F6BLX2
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

858215:THEXY RS01625
gene id: 858215:THEXY_RS01625
uniprot id: F6BGF0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

858215:THEXY RS01830
gene id: 858215:THEXY_RS01830
uniprot id: F6BGQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

858215:THEXY RS06605
gene id: 858215:THEXY_RS06605
uniprot id: F6BFI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

858215:THEXY RS00105
gene id: 858215:THEXY_RS00105
uniprot id: F6BKX0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

858215:THEXY RS09755
gene id: 858215:THEXY_RS09755
uniprot id: F6BJJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

858215:THEXY RS10295
gene id: 858215:THEXY_RS10295
uniprot id: F6BK25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

858215:THEXY RS08705
gene id: 858215:THEXY_RS08705
uniprot id: F6BI62
names: Similarity
messages: Belongs to the CpsD/CapB family.

858215:THEXY RS04640
gene id: 858215:THEXY_RS04640
uniprot id: F6BJG4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

858215:THEXY RS00410
gene id: 858215:THEXY_RS00410
uniprot id: F6BLF7
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

858215:THEXY RS10445
gene id: 858215:THEXY_RS10445
uniprot id: F6BKC8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

858215:THEXY RS07600
gene id: 858215:THEXY_RS07600
uniprot id: F6BGX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

858215:THEXY RS05045
gene id: 858215:THEXY_RS05045
uniprot id: F6BJV2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.